Hub : Genes

AMIGO2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.2740 0.0610 2.5e-07 0.228 NA 0.215 NA 0.231 9.1e-13 NA 4.6e-12 NA 6.0e-13
2 GTEx Brain Caudate basal ganglia 0.3330 0.0940 1.7e-03 0.207 NA 0.152 NA 0.166 1.4e-06 NA 4.0e-05 NA 1.7e-05
3 NTR Blood 0.0293 0.0106 8.5e-04 0.014 0.009 0.003 0.01 0.006 1.6e-05 4.0e-04 2.2e-02 0.00029 3.6e-03
4 ROSMAP Brain Pre-frontal Cortex 0.0631 0.0257 7.8e-03 0.000 0.011 0.004 0.01 0.000 3.1e-01 1.3e-02 9.7e-02 0.01700 2.9e-01
5 TCGA Pancreatic Adenocarcinoma 0.1560 0.0790 7.8e-03 0.065 -0.002 -0.004 NA 0.020 1.1e-03 3.9e-01 5.0e-01 NA 4.8e-02
6 TCGA Thyroid Carcinoma 0.1350 0.0500 7.2e-04 0.067 0.045 0.058 NA 0.062 4.5e-07 3.4e-05 2.3e-06 NA 1.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.0 1.5 5.7 -1.3 -0.3 0.0 0.4 2.4 -1.2
Bipolar Disorder or Schizophrenia 0.4 0.9 1.9 -1.4 0.4 0.7 0.6 1.2 -1.0
Depressed Affect (Nagel 2018) 0.6 1.2 3.4 0.5 -0.3 1.2 -1.3 1.9 0.5
Depression (Nagel 2018) 1.2 1.7 4.1 -2.0 -0.3 -0.0 -1.1 1.5 -1.7
Intelligence (Savage-Jansen 2018) 0.9 2.7 5.5 1.1 -2.3 1.8 -1.6 1.1 1.5
Neuroticism (Nagel 2018) 0.4 1.0 3.6 0.7 0.1 -0.0 -1.2 1.9 0.8
Schizophrenia (2018) 0.2 0.4 0.8 -0.8 0.8 0.9 0.4 -0.3 -0.3
Schizophrenia vs Biploar Disorder 0.8 1.0 4.4 0.2 1.0 -0.7 -0.2 -2.1 0.2
Worry (Nagel 2018) 0.4 0.8 1.5 0.5 0.2 -1.2 -1.0 1.2 0.6
Alzheimer’s Disease (in mother) 1.0 1.2 3.0 -0.1 1.6 1.1 1.7 -0.5 -0.0
Alzheimer’s Disease (in father) 0.6 0.7 2.9 0.6 0.1 0.1 -0.0 -1.7 0.9
Alzheimer’s Disease (including proxy) 0.6 0.9 1.5 -0.6 1.0 0.8 1.2 -1.2 -0.2
Crohns Disease (2017) 0.4 0.8 3.8 -0.4 0.5 2.0 -0.9 -0.0 -0.2
Irritable Bowel Disease (IBD) 0.3 0.6 1.2 0.8 0.9 0.6 0.4 0.8 1.1
Ulcerative Colitis (UC) 0.6 1.1 1.8 1.1 0.5 -0.9 1.0 1.2 1.4
Major Depression (MDD) 1.0 1.2 2.7 -0.8 -0.2 1.6 1.3 1.1 -1.0
Reaction Time 1.5 2.8 9.3 1.1 1.4 1.1 3.0 -1.3 1.2
Verbal and Numeric Reasoning (VNR) 1.3 3.2 6.5 1.8 -1.7 2.5 -1.4 0.8 1.9
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.2 1.6 3.8 -0.3 -1.6 -1.1 -1.9 1.3 -0.3
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.1 1.6 5.4 0.4 -1.6 2.3 -1.1 0.0 0.2
Bipolar Disorder (2011) 1.5 1.5 7.7 -0.2 -0.4 0.1 -0.8 2.8 -0.4
Body Mass Index (BMI) (2010) 1.0 1.3 5.0 -1.0 0.6 2.2 -0.0 0.4 -1.2
Coronary Artery Disease (CAD) 0.7 0.9 3.1 0.6 -0.9 1.8 -0.9 0.2 0.6
Crohns Disease (2012) 0.4 0.6 1.6 0.3 0.1 1.2 -1.3 0.3 0.5
Mean Putamen Volume 2.0 2.3 7.7 0.3 -1.6 2.8 0.5 1.7 0.2
Fasting Glucose 0.9 1.1 3.1 -1.8 0.4 -0.3 0.8 0.2 -1.5
HbA1C 0.3 0.3 0.8 -0.3 -0.7 -0.9 -0.1 0.9 -0.1
HDL Cholesterol 0.4 0.7 1.5 1.2 0.5 0.5 1.0 0.1 1.2
LDL Cholesterol 1.8 2.8 11.6 -0.8 1.0 -1.6 0.5 3.4 -0.9
Lupus 0.4 0.6 1.0 0.7 -0.6 -1.0 -0.4 0.9 0.8
Neuroticism (2016) 1.0 1.4 7.0 0.1 -0.7 -1.0 -0.3 2.6 0.3
Primary Biliary Cirrhosis 0.4 0.6 1.0 -1.0 0.9 0.7 0.1 0.8 -0.9
Rheumatoid Arthritis 0.3 0.4 0.8 -0.9 0.8 0.1 -0.2 -0.7 -0.9
Schizophrenia (2014) 0.2 0.5 1.7 -0.5 1.3 -0.1 0.9 -0.1 -0.0
Triglycerides 0.3 0.5 2.4 0.3 1.6 -0.4 -0.3 0.4 0.3
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.5 -1.1 0.9 -0.3 -0.5 0.8 -1.6
Ulcerative Colitis 0.8 1.1 2.5 1.1 0.4 -0.4 0.9 1.4 1.6
Blood Eosinophil Count 0.1 1.0 4.2 0.1 -0.2 -1.1 -2.0 0.3 0.6
Blood Platelet Count 0.3 3.6 14.1 -0.8 -1.3 2.1 -3.8 -0.7 -0.8
Blood Red Count 0.3 2.7 12.5 -0.2 1.0 1.6 3.5 -0.2 0.2
Blood White Count 0.8 6.0 17.1 -4.0 0.5 0.4 0.8 1.2 -4.1
Heel T-Score 0.1 0.7 1.0 1.0 -0.7 0.9 -0.9 0.4 0.8
BMI 0.8 4.9 9.7 -3.0 1.1 1.2 2.8 -0.3 -3.1
Height 0.5 9.7 33.3 -1.4 -1.2 4.3 -5.8 -0.8 -1.6
Waist Hip Ratio (WHR) 0.8 3.6 8.4 -0.7 -2.9 1.8 -2.8 1.2 -0.6
Systolic Blood Pressure 0.4 1.8 8.4 0.7 0.2 -0.6 0.0 2.9 1.1
Smoking Status 0.2 0.5 1.4 0.4 -1.2 -0.8 -0.8 -0.6 -0.0
Allergy or Eczema 0.7 1.8 3.6 -1.6 1.9 -0.5 1.3 -0.0 -1.6
Cardiovascular Disease 0.5 1.7 3.3 0.5 0.8 1.8 1.4 1.8 1.0
Hypothyroidism (self reported) 0.4 0.9 2.7 -0.9 -1.1 0.1 -0.6 -1.6 -0.8
Respiratory disease 0.4 0.9 4.6 0.2 0.3 0.9 2.1 0.1 -0.0
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.6 1.5 0.6 -0.3 -0.4 -0.2 1.9
Lung FEV1/FVC ratio 0.3 1.3 5.1 0.4 -1.2 -0.6 -0.7 2.3 0.5
Lung FVC 0.3 1.6 6.9 1.3 -0.5 0.0 -2.6 -0.4 0.8
Neuroticism 1.0 2.4 8.3 1.4 0.0 -0.8 -1.3 2.9 1.4
Chronotype (morning person) 0.1 0.1 0.5 0.2 0.1 0.2 0.5 0.7 0.1
Hair Pigment 0.1 1.9 7.6 -0.9 -0.8 -1.5 -2.8 0.4 -0.7
Tanning 0.1 1.7 3.8 0.9 1.6 0.7 1.4 -2.0 0.7
Hand grip strength (left) 0.8 2.2 12.0 -0.6 -0.1 3.5 0.0 1.0 -0.3
Number of treatments/medications taken 0.1 0.2 1.0 0.2 0.1 -0.5 -1.0 -0.1 -0.1
Average weekly spirits intake 1.8 2.2 4.6 -2.0 -0.8 0.5 1.9 0.4 -2.1
Sensitivity / hurt feelings 0.7 1.1 2.2 1.5 0.5 -0.6 0.7 1.1 1.5
Frequency of depressed mood in last 2 weeks 0.8 1.2 3.4 -1.8 0.0 0.0 -0.4 1.3 -1.4
Hearing difficulty/problems: Yes 0.9 1.4 4.0 -2.0 -0.5 0.6 -0.7 0.5 -1.8
Relative age of first facial hair 1.9 3.9 9.9 -2.9 -0.3 1.4 0.2 1.9 -3.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.1 -0.1 1.0 0.6 1.0 0.1 0.3
Ever used hormone-replacement therapy (HRT) 0.6 0.7 1.2 0.9 0.8 -0.4 -1.0 -1.1 0.8
Ever had hysterectomy (womb removed) 0.8 0.9 4.9 0.2 0.4 2.2 0.3 -0.6 -0.2
Systolic blood pressure, automated reading 0.3 1.0 4.5 0.5 -0.6 0.1 -0.4 2.1 0.8
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.7 0.1 1.6 -0.7 -1.0 0.8 0.7
Angina 2.0 2.6 9.7 -0.8 1.0 -3.1 0.4 -1.5 -1.3
Medication for hormone replacement therapy 0.2 0.2 0.9 0.4 1.0 0.2 0.3 -0.1 0.2
Vitamin and mineral supplements 0.8 1.0 3.3 0.2 1.5 -0.6 1.8 -0.4 0.4
Supplements: Zinc 0.3 0.4 1.0 -0.4 -0.0 -0.1 -0.8 -1.0 -0.6
Medication: Co-codamol 0.4 0.4 1.1 0.1 -1.1 -0.1 -1.0 -0.6 0.1
Medication: Metformin 1.9 2.7 6.9 2.3 1.4 0.3 -1.4 0.2 2.6
Diabetes (father) 1.2 1.5 2.8 1.6 -0.1 -1.1 0.1 -1.6 1.7
Diabetes (mother) 0.8 1.1 3.7 -1.9 0.3 0.4 -0.2 -0.3 -1.5
Severe depression (siblings) 0.1 0.1 0.4 0.2 0.5 0.3 0.6 0.0 -0.1
Pack years adult smoking proportion 0.3 0.4 1.2 0.2 1.1 -0.3 -0.8 0.6 0.4
Impedance of leg (right) 0.3 1.6 3.9 -0.9 -1.1 -2.0 -1.8 0.7 -0.2
Leg fat-free mass (left) 0.6 3.2 9.7 -1.9 0.6 3.1 0.3 -0.3 -2.3
Trunk fat percentage 1.1 4.4 10.5 -3.2 0.8 1.6 1.5 0.7 -3.1
Hand grip strength (right) 1.1 2.9 16.2 -0.2 0.2 4.0 -0.5 0.9 0.1
Townsend deprivation index at recruitment 0.3 0.5 1.3 -0.0 -0.4 -0.2 1.1 1.1 -0.4
Current tobacco smoking 0.8 1.3 3.0 -1.5 -1.3 0.9 -0.2 0.3 -1.7
Average weekly fortified wine intake 1.0 1.2 2.7 0.1 1.0 -0.9 1.5 1.6 0.7
Maternal smoking around birth 2.2 3.2 9.1 -3.0 -0.6 -0.6 0.5 0.3 -3.0
Fed-up feelings 1.2 2.2 9.3 0.2 1.3 -0.2 1.4 3.1 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 3.1 -1.4 1.8 -0.4 0.6 1.7 -1.1
Relative age voice broke 2.8 4.3 7.7 -2.7 0.5 2.6 0.3 1.9 -2.8
Taking other prescription medications 0.9 1.3 3.7 0.6 0.0 -1.6 -1.9 1.2 0.1
Age when periods started (menarche) 0.8 2.0 7.5 -1.4 0.8 -0.3 -2.7 0.3 -1.3
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 3.5 0.3 1.6 1.9 -0.7 0.7 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.3 1.9 -0.2 0.1 -1.4 -0.2 0.0 -0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.1 0.9 0.1 -0.2 -0.9 0.1 1.0
Qualifications: CSEs or equivalent 0.7 1.0 4.8 -0.2 0.6 0.6 2.2 -0.1 -0.4
Serious illness, injury or assault to yourself 0.9 1.1 1.8 1.3 0.9 -0.5 -1.4 0.8 1.2
High blood pressure 1.0 2.9 9.9 0.6 1.6 1.9 0.3 3.1 1.0
Hayfever, allergic rhinitis or eczema 0.6 1.3 5.7 -0.7 2.4 -0.5 0.7 -0.1 -1.0
Multivitamins +/- minerals 0.7 0.8 1.5 1.2 -1.2 0.5 -0.8 0.7 0.8
Stomach or abdominal pain in last month 0.2 0.2 0.7 -0.2 -0.3 0.8 -0.4 0.4 0.1
Supplements: Glucosamine 0.7 1.0 1.7 1.3 -0.4 0.7 -1.0 -0.9 1.2
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 3.0 1.3 1.6 0.7 0.6 1.7 0.7
Medication: Atenolol 0.8 1.0 4.6 -0.0 -1.0 -0.1 0.3 2.1 0.4
Medication: Levothyroxine sodium 0.4 0.6 2.6 -0.6 -0.6 0.3 -1.6 -0.2 -0.5
Sitting height 0.3 1.9 5.4 -0.8 -2.3 0.2 -1.9 -0.6 -1.1
Chronic bronchitis/emphysema (father) 0.8 0.9 2.4 0.4 -1.6 0.1 -1.1 -1.2 0.5
High blood pressure (mother) 0.4 0.6 1.5 -0.8 -0.9 -0.3 -0.3 1.2 -0.7
Body mass index (BMI) 0.9 4.0 8.2 -2.6 1.5 0.9 2.4 0.4 -2.9
Impedance of leg (left) 0.1 0.5 1.3 -0.4 -0.1 -1.1 -0.9 0.9 0.1
Leg predicted mass (left) 0.6 3.2 10.1 -1.9 0.6 3.2 0.3 -0.3 -2.3
Trunk fat mass 1.0 4.5 10.3 -3.2 0.9 2.0 1.1 0.4 -3.2
Waist circumference 1.3 4.9 10.6 -3.1 -0.5 2.4 0.0 1.7 -3.3
Number of incorrect matches in round 0.7 1.2 5.2 0.5 -0.3 0.3 1.0 -2.3 0.7
Past tobacco smoking 0.3 0.6 1.8 -0.7 0.9 -0.5 1.3 0.1 -0.7
Alcohol usually taken with meals 1.7 2.7 7.2 2.7 -0.5 -1.5 0.5 -0.3 2.5
Nervous feelings 0.4 0.7 2.2 0.7 -0.8 -1.5 -0.7 -0.2 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 4.2 -0.8 0.6 -0.4 0.1 2.0 -0.2
Hearing difficulty/problems with background noise 0.3 0.5 1.8 0.3 -0.7 0.4 1.3 -0.5 0.4
Hair/balding pattern: Pattern 2 2.8 3.5 8.1 2.7 0.6 -0.2 1.9 -1.3 2.9
Had menopause 0.8 1.0 3.9 2.0 0.0 0.2 -0.1 0.4 1.4
Had other major operations 1.4 1.7 4.1 0.5 1.7 0.6 2.0 -1.5 0.7
Forced vital capacity (FVC) 0.7 2.8 13.2 0.5 -1.0 1.6 -3.6 0.4 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 2.3 -0.0 -0.1 -1.5 0.3 -0.7 -0.2
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 6.2 1.2 0.1 -0.1 2.5 1.0 1.5
Qualifications: None of the above 0.5 1.2 3.0 -1.5 0.9 0.6 0.8 0.2 -1.7
Financial difficulties in last 2 years 1.2 1.6 4.3 -1.9 1.2 0.2 0.4 -0.3 -2.1
Mouth/teeth dental problems 1.0 1.5 2.9 0.6 -1.3 -1.7 -1.3 -1.5 0.7
Heart attack 1.8 2.3 9.7 -0.4 1.7 -3.1 0.3 0.5 -0.7
Allergy 0.6 1.4 5.5 0.5 -2.4 -0.2 -1.0 0.4 1.1
Pain all over the body in last month 1.2 1.3 2.1 -1.1 1.5 -0.9 1.4 -0.2 -1.3
Diabetes (self-reported) 2.2 3.4 8.8 2.3 1.1 -0.9 -0.1 -2.0 3.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.5 -0.5 1.6 -0.4 0.3 -1.0 -0.8
Medication: Ramipril 1.1 1.4 2.5 1.3 1.2 -1.6 -1.3 0.4 1.0
Medication: Simvastatin 1.0 1.4 2.7 1.6 -1.5 -1.4 -0.7 0.5 1.0
Fluid intelligence score 1.4 2.8 5.0 2.2 -1.7 1.3 -1.7 -0.6 2.0
Illnesses of siblings 1.3 1.9 7.7 0.3 -0.4 -1.3 1.2 -2.8 0.2
Neuroticism score 0.8 1.6 5.4 0.9 1.0 -1.1 -0.6 2.3 1.0
Weight 0.9 4.2 10.1 -2.9 0.6 2.5 0.5 0.4 -3.2
Impedance of arm (right) 0.1 0.3 0.8 -0.7 0.3 -0.2 -0.4 -0.9 -0.1
Arm fat percentage (right) 1.2 4.7 10.1 -3.2 1.4 0.9 2.3 -0.2 -3.2
Trunk fat-free mass 0.3 1.8 6.1 -1.0 -0.2 2.5 -0.9 -0.5 -1.5
Hip circumference 1.1 4.8 8.9 -2.9 1.2 2.1 1.8 1.6 -3.0
Time employed in main current job 1.6 1.9 8.9 0.1 -3.0 0.8 -0.9 1.0 -0.0
Alcohol intake versus 10 years previously 1.2 1.8 6.7 0.1 2.6 -0.9 0.5 1.6 0.5
Father’s age at death 0.4 0.5 0.8 0.9 -0.5 0.2 -0.9 0.8 0.6
Worrier / anxious feelings 0.7 1.2 3.3 0.4 1.8 0.7 1.0 1.4 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 2.9 -1.5 0.3 1.3 0.5 1.7 -1.3
Falls in the last year 0.3 0.4 0.8 -0.4 -0.4 -0.9 -0.5 0.9 -0.4
Hair/balding pattern: Pattern 3 0.7 1.0 3.7 -1.1 -1.9 -0.4 -0.8 -0.1 -0.5
Number of live births 1.1 1.5 2.2 -1.2 -1.5 -1.0 -1.5 -0.7 -1.4
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 8.4 0.6 -0.6 0.8 -2.9 0.3 0.2
Pulse rate 0.3 0.5 1.3 -0.3 0.5 0.8 0.6 1.2 -0.4
Happiness 1.1 1.3 3.1 1.2 -0.9 1.1 0.1 1.8 1.1
Noisy workplace 1.1 1.4 5.2 -1.3 0.2 -2.3 0.1 -0.6 -1.0
Qualifications: A levels/AS levels or equivalent 0.6 1.4 3.0 1.5 -0.9 -0.7 -1.3 -0.4 1.7
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.8 0.0 -0.4 -0.3 -1.7 0.8 0.5
Mouth/teeth dental problems: Dentures 1.2 2.0 6.0 -1.1 1.0 1.5 2.4 0.0 -1.2
Asthma 0.3 0.7 1.4 -0.5 1.2 0.7 0.9 0.2 -1.0
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 6.5 -1.1 -1.9 -0.2 -2.5 0.9 -1.4
Medication: Cholesterol lowering 0.7 1.2 4.1 0.8 -0.5 -2.0 -1.2 -0.3 0.6
Depression (self-reported) 1.0 1.2 3.5 -0.8 -1.2 -0.6 -1.9 1.0 -0.6
Medication: Lansoprazole 0.8 0.9 1.9 -1.0 0.1 0.9 -1.3 -0.1 -1.4
Prospective memory result 1.4 1.7 3.5 -1.3 0.9 1.6 1.9 -0.3 -1.2
Lung cancer (father) 1.0 1.2 3.3 0.7 -1.3 -1.2 -0.4 -1.8 0.1
Illnesses of mother 1.3 1.6 5.2 1.1 0.7 -0.8 1.0 -2.3 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 9.0 -0.2 -1.0 0.7 -3.0 0.4 -0.4
Pulse wave Arterial Stiffness index 0.3 0.3 0.6 -0.2 0.6 0.7 -0.4 0.8 -0.7
Impedance of arm (left) 0.1 0.3 1.5 -1.2 0.0 0.0 -0.2 -0.1 -0.5
Arm fat mass (right) 1.2 4.8 10.8 -3.2 1.3 1.5 2.0 -0.1 -3.3
Trunk predicted mass 0.3 1.7 5.6 -1.0 -0.2 2.4 -0.9 -0.5 -1.5
Standing height 0.6 5.9 15.1 -1.1 -1.9 3.8 -3.9 0.2 -1.0
Length of working week for main job 1.1 1.2 3.4 -1.2 -0.5 1.1 1.1 0.3 -1.8
Exposure to tobacco smoke at home 1.0 1.1 2.7 -1.5 0.2 0.9 0.0 -0.9 -1.6
Breastfed as a baby 0.4 0.5 1.5 -0.4 0.1 -0.9 -1.2 0.1 -0.5
Tense / ‘highly strung’ 0.8 1.3 2.0 1.4 0.9 -1.1 -1.2 0.6 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.2 10.0 0.9 1.2 -0.3 -0.5 3.2 0.8
Hair/balding pattern: Pattern 4 0.3 0.8 2.2 -0.3 1.5 -1.5 -0.5 0.3 -0.5
Birth weight of first child 2.4 4.3 19.8 -0.0 -0.2 1.8 -4.4 -1.7 0.1
Peak expiratory flow (PEF) 0.7 1.6 5.7 1.3 -0.6 0.6 -2.4 1.1 0.7
Pulse wave reflection index 0.6 0.8 1.4 1.1 -1.2 0.3 -0.9 -0.8 0.7
Ever highly irritable/argumentative for 2 days 1.9 2.3 7.2 1.1 1.1 -1.2 1.2 2.7 1.2
Loud music exposure frequency 1.7 1.9 5.3 -2.3 0.6 -0.9 -0.3 0.9 -2.0
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.6 0.5 -1.3 -0.0 -1.2 -0.3 0.7
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 3.0 -0.9 1.7 -0.5 1.4 0.2 -0.8
Blood clot in the leg (DVT) 0.4 0.5 1.6 -0.5 0.1 -1.0 -0.2 -0.1 -1.2
Medication: Paracetamol 0.4 0.7 1.3 -1.1 0.1 0.9 -0.3 1.2 -0.8
Headache pain in last month 1.6 2.8 6.9 -1.4 -1.4 0.8 -1.9 2.6 -1.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.8 -1.3 0.8 0.5 0.3 -0.8 -1.3
Glaucoma (self-reported) 0.8 1.0 4.8 0.2 -0.0 -0.7 0.7 -2.2 0.2
Gout (self-reported) 1.2 1.6 4.9 1.1 2.2 -0.5 -0.2 1.3 1.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.3 -0.3 -1.2 0.4 -1.5 -0.9 -0.2
Medication: Amlodipine 0.5 0.7 2.0 -0.5 1.4 -0.4 0.2 1.4 -0.2
Medication: Ventolin 100micrograms inhaler 1.7 2.2 5.8 -1.2 1.3 0.9 2.4 -1.2 -1.3
Birth weight 0.4 0.8 1.7 -0.8 1.3 1.1 -0.5 -0.3 -1.1
Chronic bronchitis/emphysema (mother) 1.5 1.7 4.5 -0.7 -1.9 1.0 -0.3 2.1 -0.6
High blood pressure (siblings) 1.6 2.3 11.0 -0.3 0.7 1.3 -0.8 3.3 -0.2
Forced vital capacity (FVC), Best measure 0.8 2.8 13.0 -0.4 -1.1 1.4 -3.6 0.1 -0.5
Body fat percentage 1.2 4.6 11.2 -3.3 1.2 1.2 1.8 0.5 -3.2
Leg fat percentage (right) 1.0 3.8 9.1 -3.0 1.3 -0.3 1.6 0.6 -3.0
Arm fat-free mass (right) 0.4 1.9 6.1 -1.3 -0.1 2.5 -0.2 -0.1 -1.9
Exposure to tobacco smoke outside home 1.5 2.0 5.7 1.2 2.4 -1.0 1.2 0.1 1.5
Comparative body size at age 10 0.6 1.7 5.0 -0.5 1.8 2.2 0.3 -0.8 -0.8
Number of full brothers 0.9 1.2 4.2 -2.0 -0.2 -0.5 -0.0 0.3 -1.6
Worry too long after embarrassment 0.9 1.5 2.5 1.2 -0.8 -0.9 1.2 1.4 1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 2.2 0.8 -1.0 0.6 -0.4 1.5 0.9
Wheeze or whistling in the chest in last year 1.1 2.0 3.6 -1.7 0.8 1.8 1.2 -0.6 -1.9
Number of children fathered 1.5 1.7 6.4 1.1 -0.4 -2.5 -0.4 1.1 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.0 -0.8 -0.9 -0.5 0.3 0.1 -1.0
Age at first live birth 1.0 1.8 4.1 2.0 -1.1 0.2 -1.2 0.6 1.9
Pulse wave peak to peak time 0.2 0.3 0.5 0.1 -0.7 -0.5 -0.0 -0.7 0.6
Health satisfaction 0.6 0.8 2.7 0.4 0.7 0.2 1.2 1.7 0.5
Shortness of breath walking on level ground 0.3 0.3 0.9 -0.3 1.0 0.0 0.8 -0.3 -0.6
Qualifications: College or University degree 0.6 1.9 7.5 0.4 -1.0 0.7 -1.4 2.7 0.7
Eye problems/disorders: None of the above 1.0 1.2 3.1 1.6 -0.2 0.4 0.1 1.8 1.1
Mouth/teeth dental problems: Loose teeth 1.3 1.5 3.5 1.6 1.6 -0.6 0.1 -0.3 1.9
Emphysema/chronic bronchitis 0.8 1.0 1.9 -1.1 0.6 1.4 0.5 -0.5 -1.3
Medication for pain relief, constipation, heartburn 0.9 1.5 3.8 0.4 1.4 -0.3 1.6 -2.0 0.4
Neck or shoulder pain in last month 0.2 0.3 0.9 -0.0 -0.5 -1.0 -0.5 0.4 0.3
Medication: Blood pressure 0.5 0.9 1.8 1.3 0.9 -0.3 0.4 1.2 1.2
Angina (self-reported) 2.0 2.7 9.4 -0.8 1.1 -3.1 0.5 -1.7 -1.3
Migraine (self-reported) 0.7 0.9 3.3 0.7 0.8 0.1 0.6 1.8 0.7
Medication: Ibuprofen 1.1 1.3 3.5 -0.7 -1.9 -0.2 -1.3 0.9 -1.2
Medication: Allopurinol 1.3 1.7 3.3 1.2 1.8 -0.9 -1.2 0.9 1.6
Medication: Omeprazole 0.8 1.0 3.2 0.1 1.8 1.0 0.8 0.9 0.4
Medication: Seretide 50 evohaler 1.1 1.2 2.6 -1.3 -0.5 1.6 0.5 -0.5 -1.6
Mean time to correctly identify matches 1.3 2.5 8.9 1.0 0.8 1.6 3.0 -0.4 1.2
Heart disease (mother) 0.7 0.9 2.4 -0.3 1.4 -0.5 0.1 1.5 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 4.9 1.1 0.2 0.4 2.2 0.7 1.0
Whole body fat mass 1.1 4.7 10.8 -3.3 1.1 1.7 1.5 0.1 -3.3
Leg fat mass (right) 1.1 4.2 10.3 -3.1 1.2 1.2 1.5 0.5 -3.2
Arm predicted mass (right) 0.4 1.8 5.5 -1.3 -0.1 2.3 -0.3 0.2 -1.9
Pulse rate, automated reading 0.2 0.5 0.9 0.9 0.6 -0.9 0.2 0.3 0.9
Alcohol intake frequency. 0.1 0.2 0.5 -0.2 0.7 0.7 -0.1 -0.2 -0.2
Comparative height size at age 10 0.5 2.9 12.0 -0.1 -0.4 3.5 -1.9 -1.1 -0.4
Number of full sisters 0.5 0.6 3.1 -0.2 -0.3 1.8 0.7 -0.0 -0.2
Suffer from ‘nerves’ 0.7 1.1 4.2 0.0 0.1 -2.1 0.0 1.5 0.1
Overall health rating 0.5 1.1 2.7 -0.9 1.6 -0.5 1.3 1.1 -0.5
Chest pain or discomfort 1.3 1.9 7.7 -0.4 1.8 0.2 0.2 2.8 -0.5
Had major operations 0.3 0.4 0.9 -0.5 -0.9 0.2 -0.1 -0.4 -0.9
Age at last live birth 0.3 0.5 0.9 0.9 -0.7 -0.1 -0.7 0.9 0.6
Family relationship satisfaction 0.5 0.6 1.1 0.8 0.7 0.8 0.1 1.1 1.0
Leg pain on walking 0.6 0.8 4.6 -0.2 -0.3 -0.2 -0.0 2.1 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.4 -1.2 0.1 0.4 0.5 -0.1 -1.0
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.6 -0.1 0.8 0.3 -0.4 0.4 0.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 0.4 -0.7 -1.0 0.3 -1.1 0.4
Medication: Aspirin 0.7 0.9 1.6 1.0 0.0 0.8 -1.3 1.0 1.0
Supplements: Vitamin C 0.9 1.1 2.5 -1.6 1.2 0.6 0.2 -0.6 -1.4
Knee pain experienced in last month 0.7 1.0 2.7 -1.5 0.3 0.5 0.0 1.0 -1.6
Hypertension (Self-reported) 0.8 2.1 6.1 0.3 1.7 1.8 0.5 2.5 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.4 0.1 0.3 1.2 1.1 0.7 0.1
Illnesses of father: Heart disease 1.1 1.5 3.7 -0.1 1.9 1.3 1.7 0.9 -0.2
Illnesses of siblings: Diabetes 0.9 1.1 5.0 -0.5 0.7 2.2 -0.3 0.7 -0.5
Smoking status: Previous 0.4 0.5 1.2 0.7 -0.7 -0.3 -1.1 -0.5 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 3.5 -0.7 -0.1 -0.2 -1.9 -1.3 -0.5
Whole body fat-free mass 0.4 2.3 8.1 -1.4 0.2 2.9 -0.3 -0.3 -1.9
Leg fat-free mass (right) 0.6 3.2 11.2 -1.5 1.1 3.4 0.6 -0.4 -2.0
Arm fat percentage (left) 1.2 5.0 10.9 -3.3 1.4 0.9 2.4 0.1 -3.3
Average weekly red wine intake 1.0 1.5 3.3 1.8 -0.9 -1.4 0.4 -0.8 1.5
Handedness (chirality/laterality): Left-handed 1.7 2.1 2.7 -1.6 -0.8 1.6 1.5 1.4 -1.6
Mood swings 0.7 1.3 1.6 1.3 1.3 -0.9 1.1 1.0 1.1
Loneliness, isolation 1.1 1.5 3.2 1.8 0.8 0.6 0.1 1.3 1.7
Long-standing illness, disability or infirmity 0.8 1.2 4.5 -0.7 0.7 -2.1 -0.5 -1.0 -0.6
Ever had bowel cancer screening 0.3 0.3 0.6 -0.7 -0.7 0.1 -0.5 -0.3 -0.8
Diabetes diagnosed by doctor 1.3 2.2 6.7 1.9 1.0 -0.4 -0.8 -0.8 2.6
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.2 -0.2 0.4 1.5 1.1 0.3 0.1
Friendships satisfaction 2.0 2.4 6.8 2.2 0.9 0.6 -1.2 0.2 2.6
Qualifications: nursing, teaching 0.7 1.1 2.5 1.3 -1.6 -0.1 -1.5 -0.3 0.7
Commuting to job workplace: Walk 1.1 1.2 3.1 0.4 0.2 1.7 1.3 1.5 0.3
Eye problems/disorders: Cataract 0.3 0.4 0.9 -0.8 0.2 -0.1 0.9 -0.8 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.0 1.3 -0.5 0.3 -1.7 1.2 1.2
Medication for cholesterol 0.1 0.2 1.0 0.1 -0.2 0.2 0.4 -1.0 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 5.0 0.3 -0.7 -2.2 -0.6 -0.5 -0.3
Back pain experienced in last month 0.8 1.2 5.1 0.4 -2.2 0.7 0.1 1.0 0.5
Mineral and other dietary supplements 1.9 2.5 8.1 -0.9 0.9 -0.7 2.8 2.1 -0.8
Breast cancer (self-reported) 1.0 1.2 3.1 1.8 -0.9 1.1 -0.2 0.4 1.4
Asthma (self-reported) 0.4 0.8 1.5 -0.5 1.2 1.0 0.9 -0.2 -0.9
Osteoporosis (self-reported) 0.2 0.3 0.7 -0.3 -0.8 -0.6 -0.6 -0.3 -0.1
Osteoarthritis (self-reported) 0.8 1.1 3.9 0.5 0.8 0.4 1.1 -2.0 0.5
Medication: Aspirin 0.4 0.5 1.0 0.5 0.6 0.7 -1.0 0.8 0.4
Medication: Gliclazide 1.5 1.6 2.9 -1.7 0.4 -1.0 -1.6 1.4 -1.2
Illnesses of father: None of the above (group 1) 1.2 1.5 3.6 -0.3 -1.2 0.8 -1.7 -1.9 -0.4
Smoking status: Current 0.5 0.7 1.3 -0.9 -1.1 1.1 -0.3 0.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.3 1.5 0.1 -0.1 0.1 -0.1 1.1
Whole body water mass 0.4 2.3 7.9 -1.4 0.1 2.8 -0.5 -0.3 -1.9
Leg predicted mass (right) 0.6 3.3 11.3 -1.5 1.2 3.4 0.7 -0.4 -2.0
Arm fat mass (left) 1.2 4.7 10.9 -3.2 1.1 1.6 1.8 0.2 -3.3
Number of self-reported non-cancer illnesses 0.3 0.5 1.0 1.0 0.8 -0.4 0.3 0.0 1.0
Average weekly champagne plus white wine intake 0.4 0.5 2.5 0.3 0.1 -0.0 0.6 1.6 -0.1
Miserableness 1.1 1.9 4.7 -0.6 -1.8 -0.5 -1.6 2.2 -0.7
Guilty feelings 0.8 1.2 4.5 -1.0 -0.2 -0.1 0.9 2.1 -0.8
Wears glasses or contact lenses 1.2 1.4 3.8 -0.9 -1.0 -1.0 -1.9 0.4 -1.1
Ever taken oral contraceptive pill 1.4 1.5 3.9 -1.0 -1.6 -0.6 -2.0 1.0 -0.7
Hearing aid user 0.7 0.8 3.4 -0.4 -0.0 -0.8 -1.8 0.5 -0.6
Mother’s age at death 0.3 0.3 1.2 -0.0 1.1 0.3 -0.0 -0.8 -0.2
Financial situation satisfaction 0.6 0.7 1.7 -0.3 1.0 -1.3 1.1 0.4 -0.5
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.3 -1.0 -0.3 1.1 -0.4 -0.9 -0.8
Commuting to job workplace: Public transport 0.6 0.7 1.5 0.3 -1.2 -1.1 0.8 0.8 -0.3
Eye problems/disorders: Glaucoma 1.3 1.6 8.7 -0.3 0.3 -0.7 0.3 -3.0 0.0
Medication: Blood pressure 0.1 0.2 0.7 -0.1 0.6 0.4 0.1 0.9 -0.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.2 -0.4 -0.2 0.5 1.5 0.3 -0.3
Supplements: Fish oil (including cod liver oil) 1.4 1.9 5.6 0.2 -0.7 0.5 -2.4 -2.1 0.4
High cholesterol (Self-reported) 0.7 1.3 3.0 1.6 -0.5 -1.5 0.0 0.1 1.7
Medication: Bendroflumethiazide 0.4 0.6 1.4 0.1 -0.4 1.2 0.7 1.0 -0.2
Medication: Paracetamol 0.7 1.1 3.0 -1.7 0.6 0.2 -0.0 0.9 -1.5
Medication: Lisinopril 1.4 1.9 5.3 0.8 2.0 -0.6 0.2 2.3 0.9
Medication: Atorvastatin 0.4 0.5 1.3 0.1 1.2 -0.4 0.4 -0.9 0.5
Illnesses of father: High blood pressure 1.0 1.2 4.7 -0.2 0.9 -0.1 2.2 1.3 -0.5
Alcohol drinker status: Never 0.7 0.9 2.5 -0.6 1.6 -0.7 -0.0 -1.3 -0.4
Ever smoked 0.5 0.9 2.0 0.8 -1.3 0.3 -1.4 0.1 1.0
Basal metabolic rate 0.5 2.8 8.3 -1.8 0.4 2.9 -0.0 -0.3 -2.2
Leg fat percentage (left) 1.1 3.9 8.4 -2.8 1.5 0.3 2.1 0.7 -2.9
Arm fat-free mass (left) 0.4 2.1 5.0 -1.6 0.1 2.2 -0.5 -0.3 -2.1
Number of operations (self-reported) 0.6 0.9 2.3 -0.4 -0.4 0.5 -1.4 -1.5 -0.6
Average weekly beer plus cider intake 0.7 1.0 2.1 -1.2 1.4 -0.5 0.7 -0.3 -1.2
Irritability 0.6 1.0 3.0 1.2 1.7 -0.5 -0.7 -0.5 0.8
Risk taking 0.8 1.2 3.0 -0.0 -0.6 -1.7 -1.0 -1.6 -0.4
Ever had prostate specific antigen (PSA) test 1.8 2.0 5.2 1.3 -1.8 0.0 -2.3 0.7 1.2
Fractured/broken bones in last 5 years 0.9 1.2 3.3 1.0 -1.5 0.2 -1.8 0.5 0.5
Age started oral contraceptive pill 0.7 0.9 3.1 0.5 0.0 -0.6 -1.8 -1.0 0.7
Diastolic blood pressure, automated reading 0.2 0.5 1.3 0.7 -0.7 -0.4 0.3 1.1 0.7
Ever depressed for a whole week 1.0 1.3 3.8 0.3 -1.9 1.0 1.1 1.0 0.6
Unable to work because of sickness or disability 1.7 2.2 8.5 -1.3 -0.5 -2.9 0.4 -1.0 -1.3
Commuting to job workplace: Cycle 0.1 0.2 0.4 -0.5 -0.6 0.3 -0.2 -0.3 -0.4
Myopia 1.0 1.4 3.0 1.7 -0.9 -1.1 0.7 1.0 1.3
Vascular/heart problems diagnosed by doctor 0.8 2.1 7.2 -0.6 -1.9 -0.9 -0.2 -2.7 -0.7
Cholesterol lowering medication 0.4 0.6 1.1 1.0 0.5 -0.3 -0.4 0.9 0.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.4 0.2 1.5 0.1 0.6 0.4 0.4
Pain experienced in last month 0.9 1.5 4.9 0.8 0.5 -1.4 1.0 -2.2 0.5
Supplements: Calcium 2.6 2.9 8.8 1.9 -0.8 -1.1 -3.0 0.7 1.7
Basal cell carcinoma (self-reported) 0.5 0.6 2.4 0.7 -1.6 -0.3 -0.0 0.1 0.9
Heart attack/myocardial infarction (self-reported) 1.3 1.7 7.0 -0.3 1.5 -2.6 0.1 0.7 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.3 -0.3 0.1 -0.6 0.1 -0.1 -1.1
Heart disease (siblings) 0.8 1.0 2.3 1.1 -0.5 -0.0 -1.1 1.5 1.2
Alcohol drinker status: Previous 0.5 0.6 3.0 -0.2 -1.7 -0.0 -0.1 0.5 -0.3
Pack years of smoking 0.4 0.5 1.8 0.1 0.9 0.1 -1.4 0.7 0.3
Impedance of whole body 0.1 0.3 0.9 -1.0 -0.1 -0.5 -0.7 0.3 -0.1
Leg fat mass (left) 1.2 4.7 10.6 -3.1 1.5 1.6 1.6 0.6 -3.2
Arm predicted mass (left) 0.4 2.2 5.8 -1.6 -0.1 2.4 -0.4 0.0 -2.2