Hub : Genes

AMIGO2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2740	0.0610	2.5e-07	0.228	NA	0.215	NA	0.231	9.1e-13	NA	4.6e-12	NA	6.0e-13
2	GTEx	Brain Caudate basal ganglia	0.3330	0.0940	1.7e-03	0.207	NA	0.152	NA	0.166	1.4e-06	NA	4.0e-05	NA	1.7e-05
3	NTR	Blood	0.0293	0.0106	8.5e-04	0.014	0.009	0.003	0.01	0.006	1.6e-05	4.0e-04	2.2e-02	0.00029	3.6e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.0631	0.0257	7.8e-03	0.000	0.011	0.004	0.01	0.000	3.1e-01	1.3e-02	9.7e-02	0.01700	2.9e-01
5	TCGA	Pancreatic Adenocarcinoma	0.1560	0.0790	7.8e-03	0.065	-0.002	-0.004	NA	0.020	1.1e-03	3.9e-01	5.0e-01	NA	4.8e-02
6	TCGA	Thyroid Carcinoma	0.1350	0.0500	7.2e-04	0.067	0.045	0.058	NA	0.062	4.5e-07	3.4e-05	2.3e-06	NA	1.2e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.0	1.5	5.7	-1.3	-0.3	0.0	0.4	2.4	-1.2
Bipolar Disorder or Schizophrenia	0.4	0.9	1.9	-1.4	0.4	0.7	0.6	1.2	-1.0
Depressed Affect (Nagel 2018)	0.6	1.2	3.4	0.5	-0.3	1.2	-1.3	1.9	0.5
Depression (Nagel 2018)	1.2	1.7	4.1	-2.0	-0.3	-0.0	-1.1	1.5	-1.7
Intelligence (Savage-Jansen 2018)	0.9	2.7	5.5	1.1	-2.3	1.8	-1.6	1.1	1.5
Neuroticism (Nagel 2018)	0.4	1.0	3.6	0.7	0.1	-0.0	-1.2	1.9	0.8
Schizophrenia (2018)	0.2	0.4	0.8	-0.8	0.8	0.9	0.4	-0.3	-0.3
Schizophrenia vs Biploar Disorder	0.8	1.0	4.4	0.2	1.0	-0.7	-0.2	-2.1	0.2
Worry (Nagel 2018)	0.4	0.8	1.5	0.5	0.2	-1.2	-1.0	1.2	0.6
Alzheimer’s Disease (in mother)	1.0	1.2	3.0	-0.1	1.6	1.1	1.7	-0.5	-0.0
Alzheimer’s Disease (in father)	0.6	0.7	2.9	0.6	0.1	0.1	-0.0	-1.7	0.9
Alzheimer’s Disease (including proxy)	0.6	0.9	1.5	-0.6	1.0	0.8	1.2	-1.2	-0.2
Crohns Disease (2017)	0.4	0.8	3.8	-0.4	0.5	2.0	-0.9	-0.0	-0.2
Irritable Bowel Disease (IBD)	0.3	0.6	1.2	0.8	0.9	0.6	0.4	0.8	1.1
Ulcerative Colitis (UC)	0.6	1.1	1.8	1.1	0.5	-0.9	1.0	1.2	1.4
Major Depression (MDD)	1.0	1.2	2.7	-0.8	-0.2	1.6	1.3	1.1	-1.0
Reaction Time	1.5	2.8	9.3	1.1	1.4	1.1	3.0	-1.3	1.2
Verbal and Numeric Reasoning (VNR)	1.3	3.2	6.5	1.8	-1.7	2.5	-1.4	0.8	1.9
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.2	1.6	3.8	-0.3	-1.6	-1.1	-1.9	1.3	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.1	1.6	5.4	0.4	-1.6	2.3	-1.1	0.0	0.2
Bipolar Disorder (2011)	1.5	1.5	7.7	-0.2	-0.4	0.1	-0.8	2.8	-0.4
Body Mass Index (BMI) (2010)	1.0	1.3	5.0	-1.0	0.6	2.2	-0.0	0.4	-1.2
Coronary Artery Disease (CAD)	0.7	0.9	3.1	0.6	-0.9	1.8	-0.9	0.2	0.6
Crohns Disease (2012)	0.4	0.6	1.6	0.3	0.1	1.2	-1.3	0.3	0.5
Mean Putamen Volume	2.0	2.3	7.7	0.3	-1.6	2.8	0.5	1.7	0.2
Fasting Glucose	0.9	1.1	3.1	-1.8	0.4	-0.3	0.8	0.2	-1.5
HbA1C	0.3	0.3	0.8	-0.3	-0.7	-0.9	-0.1	0.9	-0.1
HDL Cholesterol	0.4	0.7	1.5	1.2	0.5	0.5	1.0	0.1	1.2
LDL Cholesterol	1.8	2.8	11.6	-0.8	1.0	-1.6	0.5	3.4	-0.9
Lupus	0.4	0.6	1.0	0.7	-0.6	-1.0	-0.4	0.9	0.8
Neuroticism (2016)	1.0	1.4	7.0	0.1	-0.7	-1.0	-0.3	2.6	0.3
Primary Biliary Cirrhosis	0.4	0.6	1.0	-1.0	0.9	0.7	0.1	0.8	-0.9
Rheumatoid Arthritis	0.3	0.4	0.8	-0.9	0.8	0.1	-0.2	-0.7	-0.9
Schizophrenia (2014)	0.2	0.5	1.7	-0.5	1.3	-0.1	0.9	-0.1	-0.0
Triglycerides	0.3	0.5	2.4	0.3	1.6	-0.4	-0.3	0.4	0.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.5	-1.1	0.9	-0.3	-0.5	0.8	-1.6
Ulcerative Colitis	0.8	1.1	2.5	1.1	0.4	-0.4	0.9	1.4	1.6
Blood Eosinophil Count	0.1	1.0	4.2	0.1	-0.2	-1.1	-2.0	0.3	0.6
Blood Platelet Count	0.3	3.6	14.1	-0.8	-1.3	2.1	-3.8	-0.7	-0.8
Blood Red Count	0.3	2.7	12.5	-0.2	1.0	1.6	3.5	-0.2	0.2
Blood White Count	0.8	6.0	17.1	-4.0	0.5	0.4	0.8	1.2	-4.1
Heel T-Score	0.1	0.7	1.0	1.0	-0.7	0.9	-0.9	0.4	0.8
BMI	0.8	4.9	9.7	-3.0	1.1	1.2	2.8	-0.3	-3.1
Height	0.5	9.7	33.3	-1.4	-1.2	4.3	-5.8	-0.8	-1.6
Waist Hip Ratio (WHR)	0.8	3.6	8.4	-0.7	-2.9	1.8	-2.8	1.2	-0.6
Systolic Blood Pressure	0.4	1.8	8.4	0.7	0.2	-0.6	0.0	2.9	1.1
Smoking Status	0.2	0.5	1.4	0.4	-1.2	-0.8	-0.8	-0.6	-0.0
Allergy or Eczema	0.7	1.8	3.6	-1.6	1.9	-0.5	1.3	-0.0	-1.6
Cardiovascular Disease	0.5	1.7	3.3	0.5	0.8	1.8	1.4	1.8	1.0
Hypothyroidism (self reported)	0.4	0.9	2.7	-0.9	-1.1	0.1	-0.6	-1.6	-0.8
Respiratory disease	0.4	0.9	4.6	0.2	0.3	0.9	2.1	0.1	-0.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.6	1.5	0.6	-0.3	-0.4	-0.2	1.9
Lung FEV1/FVC ratio	0.3	1.3	5.1	0.4	-1.2	-0.6	-0.7	2.3	0.5
Lung FVC	0.3	1.6	6.9	1.3	-0.5	0.0	-2.6	-0.4	0.8
Neuroticism	1.0	2.4	8.3	1.4	0.0	-0.8	-1.3	2.9	1.4
Chronotype (morning person)	0.1	0.1	0.5	0.2	0.1	0.2	0.5	0.7	0.1
Hair Pigment	0.1	1.9	7.6	-0.9	-0.8	-1.5	-2.8	0.4	-0.7
Tanning	0.1	1.7	3.8	0.9	1.6	0.7	1.4	-2.0	0.7
Hand grip strength (left)	0.8	2.2	12.0	-0.6	-0.1	3.5	0.0	1.0	-0.3
Number of treatments/medications taken	0.1	0.2	1.0	0.2	0.1	-0.5	-1.0	-0.1	-0.1
Average weekly spirits intake	1.8	2.2	4.6	-2.0	-0.8	0.5	1.9	0.4	-2.1
Sensitivity / hurt feelings	0.7	1.1	2.2	1.5	0.5	-0.6	0.7	1.1	1.5
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.4	-1.8	0.0	0.0	-0.4	1.3	-1.4
Hearing difficulty/problems: Yes	0.9	1.4	4.0	-2.0	-0.5	0.6	-0.7	0.5	-1.8
Relative age of first facial hair	1.9	3.9	9.9	-2.9	-0.3	1.4	0.2	1.9	-3.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	-0.1	1.0	0.6	1.0	0.1	0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.2	0.9	0.8	-0.4	-1.0	-1.1	0.8
Ever had hysterectomy (womb removed)	0.8	0.9	4.9	0.2	0.4	2.2	0.3	-0.6	-0.2
Systolic blood pressure, automated reading	0.3	1.0	4.5	0.5	-0.6	0.1	-0.4	2.1	0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.7	0.1	1.6	-0.7	-1.0	0.8	0.7
Angina	2.0	2.6	9.7	-0.8	1.0	-3.1	0.4	-1.5	-1.3
Medication for hormone replacement therapy	0.2	0.2	0.9	0.4	1.0	0.2	0.3	-0.1	0.2
Vitamin and mineral supplements	0.8	1.0	3.3	0.2	1.5	-0.6	1.8	-0.4	0.4
Supplements: Zinc	0.3	0.4	1.0	-0.4	-0.0	-0.1	-0.8	-1.0	-0.6
Medication: Co-codamol	0.4	0.4	1.1	0.1	-1.1	-0.1	-1.0	-0.6	0.1
Medication: Metformin	1.9	2.7	6.9	2.3	1.4	0.3	-1.4	0.2	2.6
Diabetes (father)	1.2	1.5	2.8	1.6	-0.1	-1.1	0.1	-1.6	1.7
Diabetes (mother)	0.8	1.1	3.7	-1.9	0.3	0.4	-0.2	-0.3	-1.5
Severe depression (siblings)	0.1	0.1	0.4	0.2	0.5	0.3	0.6	0.0	-0.1
Pack years adult smoking proportion	0.3	0.4	1.2	0.2	1.1	-0.3	-0.8	0.6	0.4
Impedance of leg (right)	0.3	1.6	3.9	-0.9	-1.1	-2.0	-1.8	0.7	-0.2
Leg fat-free mass (left)	0.6	3.2	9.7	-1.9	0.6	3.1	0.3	-0.3	-2.3
Trunk fat percentage	1.1	4.4	10.5	-3.2	0.8	1.6	1.5	0.7	-3.1
Hand grip strength (right)	1.1	2.9	16.2	-0.2	0.2	4.0	-0.5	0.9	0.1
Townsend deprivation index at recruitment	0.3	0.5	1.3	-0.0	-0.4	-0.2	1.1	1.1	-0.4
Current tobacco smoking	0.8	1.3	3.0	-1.5	-1.3	0.9	-0.2	0.3	-1.7
Average weekly fortified wine intake	1.0	1.2	2.7	0.1	1.0	-0.9	1.5	1.6	0.7
Maternal smoking around birth	2.2	3.2	9.1	-3.0	-0.6	-0.6	0.5	0.3	-3.0
Fed-up feelings	1.2	2.2	9.3	0.2	1.3	-0.2	1.4	3.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.1	-1.4	1.8	-0.4	0.6	1.7	-1.1
Relative age voice broke	2.8	4.3	7.7	-2.7	0.5	2.6	0.3	1.9	-2.8
Taking other prescription medications	0.9	1.3	3.7	0.6	0.0	-1.6	-1.9	1.2	0.1
Age when periods started (menarche)	0.8	2.0	7.5	-1.4	0.8	-0.3	-2.7	0.3	-1.3
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.5	0.3	1.6	1.9	-0.7	0.7	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	1.9	-0.2	0.1	-1.4	-0.2	0.0	-0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.1	0.9	0.1	-0.2	-0.9	0.1	1.0
Qualifications: CSEs or equivalent	0.7	1.0	4.8	-0.2	0.6	0.6	2.2	-0.1	-0.4
Serious illness, injury or assault to yourself	0.9	1.1	1.8	1.3	0.9	-0.5	-1.4	0.8	1.2
High blood pressure	1.0	2.9	9.9	0.6	1.6	1.9	0.3	3.1	1.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	5.7	-0.7	2.4	-0.5	0.7	-0.1	-1.0
Multivitamins +/- minerals	0.7	0.8	1.5	1.2	-1.2	0.5	-0.8	0.7	0.8
Stomach or abdominal pain in last month	0.2	0.2	0.7	-0.2	-0.3	0.8	-0.4	0.4	0.1
Supplements: Glucosamine	0.7	1.0	1.7	1.3	-0.4	0.7	-1.0	-0.9	1.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.0	1.3	1.6	0.7	0.6	1.7	0.7
Medication: Atenolol	0.8	1.0	4.6	-0.0	-1.0	-0.1	0.3	2.1	0.4
Medication: Levothyroxine sodium	0.4	0.6	2.6	-0.6	-0.6	0.3	-1.6	-0.2	-0.5
Sitting height	0.3	1.9	5.4	-0.8	-2.3	0.2	-1.9	-0.6	-1.1
Chronic bronchitis/emphysema (father)	0.8	0.9	2.4	0.4	-1.6	0.1	-1.1	-1.2	0.5
High blood pressure (mother)	0.4	0.6	1.5	-0.8	-0.9	-0.3	-0.3	1.2	-0.7
Body mass index (BMI)	0.9	4.0	8.2	-2.6	1.5	0.9	2.4	0.4	-2.9
Impedance of leg (left)	0.1	0.5	1.3	-0.4	-0.1	-1.1	-0.9	0.9	0.1
Leg predicted mass (left)	0.6	3.2	10.1	-1.9	0.6	3.2	0.3	-0.3	-2.3
Trunk fat mass	1.0	4.5	10.3	-3.2	0.9	2.0	1.1	0.4	-3.2
Waist circumference	1.3	4.9	10.6	-3.1	-0.5	2.4	0.0	1.7	-3.3
Number of incorrect matches in round	0.7	1.2	5.2	0.5	-0.3	0.3	1.0	-2.3	0.7
Past tobacco smoking	0.3	0.6	1.8	-0.7	0.9	-0.5	1.3	0.1	-0.7
Alcohol usually taken with meals	1.7	2.7	7.2	2.7	-0.5	-1.5	0.5	-0.3	2.5
Nervous feelings	0.4	0.7	2.2	0.7	-0.8	-1.5	-0.7	-0.2	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	4.2	-0.8	0.6	-0.4	0.1	2.0	-0.2
Hearing difficulty/problems with background noise	0.3	0.5	1.8	0.3	-0.7	0.4	1.3	-0.5	0.4
Hair/balding pattern: Pattern 2	2.8	3.5	8.1	2.7	0.6	-0.2	1.9	-1.3	2.9
Had menopause	0.8	1.0	3.9	2.0	0.0	0.2	-0.1	0.4	1.4
Had other major operations	1.4	1.7	4.1	0.5	1.7	0.6	2.0	-1.5	0.7
Forced vital capacity (FVC)	0.7	2.8	13.2	0.5	-1.0	1.6	-3.6	0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.3	-0.0	-0.1	-1.5	0.3	-0.7	-0.2
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	6.2	1.2	0.1	-0.1	2.5	1.0	1.5
Qualifications: None of the above	0.5	1.2	3.0	-1.5	0.9	0.6	0.8	0.2	-1.7
Financial difficulties in last 2 years	1.2	1.6	4.3	-1.9	1.2	0.2	0.4	-0.3	-2.1
Mouth/teeth dental problems	1.0	1.5	2.9	0.6	-1.3	-1.7	-1.3	-1.5	0.7
Heart attack	1.8	2.3	9.7	-0.4	1.7	-3.1	0.3	0.5	-0.7
Allergy	0.6	1.4	5.5	0.5	-2.4	-0.2	-1.0	0.4	1.1
Pain all over the body in last month	1.2	1.3	2.1	-1.1	1.5	-0.9	1.4	-0.2	-1.3
Diabetes (self-reported)	2.2	3.4	8.8	2.3	1.1	-0.9	-0.1	-2.0	3.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.5	-0.5	1.6	-0.4	0.3	-1.0	-0.8
Medication: Ramipril	1.1	1.4	2.5	1.3	1.2	-1.6	-1.3	0.4	1.0
Medication: Simvastatin	1.0	1.4	2.7	1.6	-1.5	-1.4	-0.7	0.5	1.0
Fluid intelligence score	1.4	2.8	5.0	2.2	-1.7	1.3	-1.7	-0.6	2.0
Illnesses of siblings	1.3	1.9	7.7	0.3	-0.4	-1.3	1.2	-2.8	0.2
Neuroticism score	0.8	1.6	5.4	0.9	1.0	-1.1	-0.6	2.3	1.0
Weight	0.9	4.2	10.1	-2.9	0.6	2.5	0.5	0.4	-3.2
Impedance of arm (right)	0.1	0.3	0.8	-0.7	0.3	-0.2	-0.4	-0.9	-0.1
Arm fat percentage (right)	1.2	4.7	10.1	-3.2	1.4	0.9	2.3	-0.2	-3.2
Trunk fat-free mass	0.3	1.8	6.1	-1.0	-0.2	2.5	-0.9	-0.5	-1.5
Hip circumference	1.1	4.8	8.9	-2.9	1.2	2.1	1.8	1.6	-3.0
Time employed in main current job	1.6	1.9	8.9	0.1	-3.0	0.8	-0.9	1.0	-0.0
Alcohol intake versus 10 years previously	1.2	1.8	6.7	0.1	2.6	-0.9	0.5	1.6	0.5
Father’s age at death	0.4	0.5	0.8	0.9	-0.5	0.2	-0.9	0.8	0.6
Worrier / anxious feelings	0.7	1.2	3.3	0.4	1.8	0.7	1.0	1.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.9	-1.5	0.3	1.3	0.5	1.7	-1.3
Falls in the last year	0.3	0.4	0.8	-0.4	-0.4	-0.9	-0.5	0.9	-0.4
Hair/balding pattern: Pattern 3	0.7	1.0	3.7	-1.1	-1.9	-0.4	-0.8	-0.1	-0.5
Number of live births	1.1	1.5	2.2	-1.2	-1.5	-1.0	-1.5	-0.7	-1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	8.4	0.6	-0.6	0.8	-2.9	0.3	0.2
Pulse rate	0.3	0.5	1.3	-0.3	0.5	0.8	0.6	1.2	-0.4
Happiness	1.1	1.3	3.1	1.2	-0.9	1.1	0.1	1.8	1.1
Noisy workplace	1.1	1.4	5.2	-1.3	0.2	-2.3	0.1	-0.6	-1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.0	1.5	-0.9	-0.7	-1.3	-0.4	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.8	0.0	-0.4	-0.3	-1.7	0.8	0.5
Mouth/teeth dental problems: Dentures	1.2	2.0	6.0	-1.1	1.0	1.5	2.4	0.0	-1.2
Asthma	0.3	0.7	1.4	-0.5	1.2	0.7	0.9	0.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	6.5	-1.1	-1.9	-0.2	-2.5	0.9	-1.4
Medication: Cholesterol lowering	0.7	1.2	4.1	0.8	-0.5	-2.0	-1.2	-0.3	0.6
Depression (self-reported)	1.0	1.2	3.5	-0.8	-1.2	-0.6	-1.9	1.0	-0.6
Medication: Lansoprazole	0.8	0.9	1.9	-1.0	0.1	0.9	-1.3	-0.1	-1.4
Prospective memory result	1.4	1.7	3.5	-1.3	0.9	1.6	1.9	-0.3	-1.2
Lung cancer (father)	1.0	1.2	3.3	0.7	-1.3	-1.2	-0.4	-1.8	0.1
Illnesses of mother	1.3	1.6	5.2	1.1	0.7	-0.8	1.0	-2.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	9.0	-0.2	-1.0	0.7	-3.0	0.4	-0.4
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	-0.2	0.6	0.7	-0.4	0.8	-0.7
Impedance of arm (left)	0.1	0.3	1.5	-1.2	0.0	0.0	-0.2	-0.1	-0.5
Arm fat mass (right)	1.2	4.8	10.8	-3.2	1.3	1.5	2.0	-0.1	-3.3
Trunk predicted mass	0.3	1.7	5.6	-1.0	-0.2	2.4	-0.9	-0.5	-1.5
Standing height	0.6	5.9	15.1	-1.1	-1.9	3.8	-3.9	0.2	-1.0
Length of working week for main job	1.1	1.2	3.4	-1.2	-0.5	1.1	1.1	0.3	-1.8
Exposure to tobacco smoke at home	1.0	1.1	2.7	-1.5	0.2	0.9	0.0	-0.9	-1.6
Breastfed as a baby	0.4	0.5	1.5	-0.4	0.1	-0.9	-1.2	0.1	-0.5
Tense / ‘highly strung’	0.8	1.3	2.0	1.4	0.9	-1.1	-1.2	0.6	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	10.0	0.9	1.2	-0.3	-0.5	3.2	0.8
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	-0.3	1.5	-1.5	-0.5	0.3	-0.5
Birth weight of first child	2.4	4.3	19.8	-0.0	-0.2	1.8	-4.4	-1.7	0.1
Peak expiratory flow (PEF)	0.7	1.6	5.7	1.3	-0.6	0.6	-2.4	1.1	0.7
Pulse wave reflection index	0.6	0.8	1.4	1.1	-1.2	0.3	-0.9	-0.8	0.7
Ever highly irritable/argumentative for 2 days	1.9	2.3	7.2	1.1	1.1	-1.2	1.2	2.7	1.2
Loud music exposure frequency	1.7	1.9	5.3	-2.3	0.6	-0.9	-0.3	0.9	-2.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.6	0.5	-1.3	-0.0	-1.2	-0.3	0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.0	-0.9	1.7	-0.5	1.4	0.2	-0.8
Blood clot in the leg (DVT)	0.4	0.5	1.6	-0.5	0.1	-1.0	-0.2	-0.1	-1.2
Medication: Paracetamol	0.4	0.7	1.3	-1.1	0.1	0.9	-0.3	1.2	-0.8
Headache pain in last month	1.6	2.8	6.9	-1.4	-1.4	0.8	-1.9	2.6	-1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.8	-1.3	0.8	0.5	0.3	-0.8	-1.3
Glaucoma (self-reported)	0.8	1.0	4.8	0.2	-0.0	-0.7	0.7	-2.2	0.2
Gout (self-reported)	1.2	1.6	4.9	1.1	2.2	-0.5	-0.2	1.3	1.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.3	-0.3	-1.2	0.4	-1.5	-0.9	-0.2
Medication: Amlodipine	0.5	0.7	2.0	-0.5	1.4	-0.4	0.2	1.4	-0.2
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.8	-1.2	1.3	0.9	2.4	-1.2	-1.3
Birth weight	0.4	0.8	1.7	-0.8	1.3	1.1	-0.5	-0.3	-1.1
Chronic bronchitis/emphysema (mother)	1.5	1.7	4.5	-0.7	-1.9	1.0	-0.3	2.1	-0.6
High blood pressure (siblings)	1.6	2.3	11.0	-0.3	0.7	1.3	-0.8	3.3	-0.2
Forced vital capacity (FVC), Best measure	0.8	2.8	13.0	-0.4	-1.1	1.4	-3.6	0.1	-0.5
Body fat percentage	1.2	4.6	11.2	-3.3	1.2	1.2	1.8	0.5	-3.2
Leg fat percentage (right)	1.0	3.8	9.1	-3.0	1.3	-0.3	1.6	0.6	-3.0
Arm fat-free mass (right)	0.4	1.9	6.1	-1.3	-0.1	2.5	-0.2	-0.1	-1.9
Exposure to tobacco smoke outside home	1.5	2.0	5.7	1.2	2.4	-1.0	1.2	0.1	1.5
Comparative body size at age 10	0.6	1.7	5.0	-0.5	1.8	2.2	0.3	-0.8	-0.8
Number of full brothers	0.9	1.2	4.2	-2.0	-0.2	-0.5	-0.0	0.3	-1.6
Worry too long after embarrassment	0.9	1.5	2.5	1.2	-0.8	-0.9	1.2	1.4	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.2	0.8	-1.0	0.6	-0.4	1.5	0.9
Wheeze or whistling in the chest in last year	1.1	2.0	3.6	-1.7	0.8	1.8	1.2	-0.6	-1.9
Number of children fathered	1.5	1.7	6.4	1.1	-0.4	-2.5	-0.4	1.1	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-0.8	-0.9	-0.5	0.3	0.1	-1.0
Age at first live birth	1.0	1.8	4.1	2.0	-1.1	0.2	-1.2	0.6	1.9
Pulse wave peak to peak time	0.2	0.3	0.5	0.1	-0.7	-0.5	-0.0	-0.7	0.6
Health satisfaction	0.6	0.8	2.7	0.4	0.7	0.2	1.2	1.7	0.5
Shortness of breath walking on level ground	0.3	0.3	0.9	-0.3	1.0	0.0	0.8	-0.3	-0.6
Qualifications: College or University degree	0.6	1.9	7.5	0.4	-1.0	0.7	-1.4	2.7	0.7
Eye problems/disorders: None of the above	1.0	1.2	3.1	1.6	-0.2	0.4	0.1	1.8	1.1
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.5	1.6	1.6	-0.6	0.1	-0.3	1.9
Emphysema/chronic bronchitis	0.8	1.0	1.9	-1.1	0.6	1.4	0.5	-0.5	-1.3
Medication for pain relief, constipation, heartburn	0.9	1.5	3.8	0.4	1.4	-0.3	1.6	-2.0	0.4
Neck or shoulder pain in last month	0.2	0.3	0.9	-0.0	-0.5	-1.0	-0.5	0.4	0.3
Medication: Blood pressure	0.5	0.9	1.8	1.3	0.9	-0.3	0.4	1.2	1.2
Angina (self-reported)	2.0	2.7	9.4	-0.8	1.1	-3.1	0.5	-1.7	-1.3
Migraine (self-reported)	0.7	0.9	3.3	0.7	0.8	0.1	0.6	1.8	0.7
Medication: Ibuprofen	1.1	1.3	3.5	-0.7	-1.9	-0.2	-1.3	0.9	-1.2
Medication: Allopurinol	1.3	1.7	3.3	1.2	1.8	-0.9	-1.2	0.9	1.6
Medication: Omeprazole	0.8	1.0	3.2	0.1	1.8	1.0	0.8	0.9	0.4
Medication: Seretide 50 evohaler	1.1	1.2	2.6	-1.3	-0.5	1.6	0.5	-0.5	-1.6
Mean time to correctly identify matches	1.3	2.5	8.9	1.0	0.8	1.6	3.0	-0.4	1.2
Heart disease (mother)	0.7	0.9	2.4	-0.3	1.4	-0.5	0.1	1.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	4.9	1.1	0.2	0.4	2.2	0.7	1.0
Whole body fat mass	1.1	4.7	10.8	-3.3	1.1	1.7	1.5	0.1	-3.3
Leg fat mass (right)	1.1	4.2	10.3	-3.1	1.2	1.2	1.5	0.5	-3.2
Arm predicted mass (right)	0.4	1.8	5.5	-1.3	-0.1	2.3	-0.3	0.2	-1.9
Pulse rate, automated reading	0.2	0.5	0.9	0.9	0.6	-0.9	0.2	0.3	0.9
Alcohol intake frequency.	0.1	0.2	0.5	-0.2	0.7	0.7	-0.1	-0.2	-0.2
Comparative height size at age 10	0.5	2.9	12.0	-0.1	-0.4	3.5	-1.9	-1.1	-0.4
Number of full sisters	0.5	0.6	3.1	-0.2	-0.3	1.8	0.7	-0.0	-0.2
Suffer from ‘nerves’	0.7	1.1	4.2	0.0	0.1	-2.1	0.0	1.5	0.1
Overall health rating	0.5	1.1	2.7	-0.9	1.6	-0.5	1.3	1.1	-0.5
Chest pain or discomfort	1.3	1.9	7.7	-0.4	1.8	0.2	0.2	2.8	-0.5
Had major operations	0.3	0.4	0.9	-0.5	-0.9	0.2	-0.1	-0.4	-0.9
Age at last live birth	0.3	0.5	0.9	0.9	-0.7	-0.1	-0.7	0.9	0.6
Family relationship satisfaction	0.5	0.6	1.1	0.8	0.7	0.8	0.1	1.1	1.0
Leg pain on walking	0.6	0.8	4.6	-0.2	-0.3	-0.2	-0.0	2.1	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	-1.2	0.1	0.4	0.5	-0.1	-1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	-0.1	0.8	0.3	-0.4	0.4	0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	0.4	-0.7	-1.0	0.3	-1.1	0.4
Medication: Aspirin	0.7	0.9	1.6	1.0	0.0	0.8	-1.3	1.0	1.0
Supplements: Vitamin C	0.9	1.1	2.5	-1.6	1.2	0.6	0.2	-0.6	-1.4
Knee pain experienced in last month	0.7	1.0	2.7	-1.5	0.3	0.5	0.0	1.0	-1.6
Hypertension (Self-reported)	0.8	2.1	6.1	0.3	1.7	1.8	0.5	2.5	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.4	0.1	0.3	1.2	1.1	0.7	0.1
Illnesses of father: Heart disease	1.1	1.5	3.7	-0.1	1.9	1.3	1.7	0.9	-0.2
Illnesses of siblings: Diabetes	0.9	1.1	5.0	-0.5	0.7	2.2	-0.3	0.7	-0.5
Smoking status: Previous	0.4	0.5	1.2	0.7	-0.7	-0.3	-1.1	-0.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.5	-0.7	-0.1	-0.2	-1.9	-1.3	-0.5
Whole body fat-free mass	0.4	2.3	8.1	-1.4	0.2	2.9	-0.3	-0.3	-1.9
Leg fat-free mass (right)	0.6	3.2	11.2	-1.5	1.1	3.4	0.6	-0.4	-2.0
Arm fat percentage (left)	1.2	5.0	10.9	-3.3	1.4	0.9	2.4	0.1	-3.3
Average weekly red wine intake	1.0	1.5	3.3	1.8	-0.9	-1.4	0.4	-0.8	1.5
Handedness (chirality/laterality): Left-handed	1.7	2.1	2.7	-1.6	-0.8	1.6	1.5	1.4	-1.6
Mood swings	0.7	1.3	1.6	1.3	1.3	-0.9	1.1	1.0	1.1
Loneliness, isolation	1.1	1.5	3.2	1.8	0.8	0.6	0.1	1.3	1.7
Long-standing illness, disability or infirmity	0.8	1.2	4.5	-0.7	0.7	-2.1	-0.5	-1.0	-0.6
Ever had bowel cancer screening	0.3	0.3	0.6	-0.7	-0.7	0.1	-0.5	-0.3	-0.8
Diabetes diagnosed by doctor	1.3	2.2	6.7	1.9	1.0	-0.4	-0.8	-0.8	2.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.2	-0.2	0.4	1.5	1.1	0.3	0.1
Friendships satisfaction	2.0	2.4	6.8	2.2	0.9	0.6	-1.2	0.2	2.6
Qualifications: nursing, teaching	0.7	1.1	2.5	1.3	-1.6	-0.1	-1.5	-0.3	0.7
Commuting to job workplace: Walk	1.1	1.2	3.1	0.4	0.2	1.7	1.3	1.5	0.3
Eye problems/disorders: Cataract	0.3	0.4	0.9	-0.8	0.2	-0.1	0.9	-0.8	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.0	1.3	-0.5	0.3	-1.7	1.2	1.2
Medication for cholesterol	0.1	0.2	1.0	0.1	-0.2	0.2	0.4	-1.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	5.0	0.3	-0.7	-2.2	-0.6	-0.5	-0.3
Back pain experienced in last month	0.8	1.2	5.1	0.4	-2.2	0.7	0.1	1.0	0.5
Mineral and other dietary supplements	1.9	2.5	8.1	-0.9	0.9	-0.7	2.8	2.1	-0.8
Breast cancer (self-reported)	1.0	1.2	3.1	1.8	-0.9	1.1	-0.2	0.4	1.4
Asthma (self-reported)	0.4	0.8	1.5	-0.5	1.2	1.0	0.9	-0.2	-0.9
Osteoporosis (self-reported)	0.2	0.3	0.7	-0.3	-0.8	-0.6	-0.6	-0.3	-0.1
Osteoarthritis (self-reported)	0.8	1.1	3.9	0.5	0.8	0.4	1.1	-2.0	0.5
Medication: Aspirin	0.4	0.5	1.0	0.5	0.6	0.7	-1.0	0.8	0.4
Medication: Gliclazide	1.5	1.6	2.9	-1.7	0.4	-1.0	-1.6	1.4	-1.2
Illnesses of father: None of the above (group 1)	1.2	1.5	3.6	-0.3	-1.2	0.8	-1.7	-1.9	-0.4
Smoking status: Current	0.5	0.7	1.3	-0.9	-1.1	1.1	-0.3	0.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.3	1.5	0.1	-0.1	0.1	-0.1	1.1
Whole body water mass	0.4	2.3	7.9	-1.4	0.1	2.8	-0.5	-0.3	-1.9
Leg predicted mass (right)	0.6	3.3	11.3	-1.5	1.2	3.4	0.7	-0.4	-2.0
Arm fat mass (left)	1.2	4.7	10.9	-3.2	1.1	1.6	1.8	0.2	-3.3
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	1.0	0.8	-0.4	0.3	0.0	1.0
Average weekly champagne plus white wine intake	0.4	0.5	2.5	0.3	0.1	-0.0	0.6	1.6	-0.1
Miserableness	1.1	1.9	4.7	-0.6	-1.8	-0.5	-1.6	2.2	-0.7
Guilty feelings	0.8	1.2	4.5	-1.0	-0.2	-0.1	0.9	2.1	-0.8
Wears glasses or contact lenses	1.2	1.4	3.8	-0.9	-1.0	-1.0	-1.9	0.4	-1.1
Ever taken oral contraceptive pill	1.4	1.5	3.9	-1.0	-1.6	-0.6	-2.0	1.0	-0.7
Hearing aid user	0.7	0.8	3.4	-0.4	-0.0	-0.8	-1.8	0.5	-0.6
Mother’s age at death	0.3	0.3	1.2	-0.0	1.1	0.3	-0.0	-0.8	-0.2
Financial situation satisfaction	0.6	0.7	1.7	-0.3	1.0	-1.3	1.1	0.4	-0.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-1.0	-0.3	1.1	-0.4	-0.9	-0.8
Commuting to job workplace: Public transport	0.6	0.7	1.5	0.3	-1.2	-1.1	0.8	0.8	-0.3
Eye problems/disorders: Glaucoma	1.3	1.6	8.7	-0.3	0.3	-0.7	0.3	-3.0	0.0
Medication: Blood pressure	0.1	0.2	0.7	-0.1	0.6	0.4	0.1	0.9	-0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.2	-0.4	-0.2	0.5	1.5	0.3	-0.3
Supplements: Fish oil (including cod liver oil)	1.4	1.9	5.6	0.2	-0.7	0.5	-2.4	-2.1	0.4
High cholesterol (Self-reported)	0.7	1.3	3.0	1.6	-0.5	-1.5	0.0	0.1	1.7
Medication: Bendroflumethiazide	0.4	0.6	1.4	0.1	-0.4	1.2	0.7	1.0	-0.2
Medication: Paracetamol	0.7	1.1	3.0	-1.7	0.6	0.2	-0.0	0.9	-1.5
Medication: Lisinopril	1.4	1.9	5.3	0.8	2.0	-0.6	0.2	2.3	0.9
Medication: Atorvastatin	0.4	0.5	1.3	0.1	1.2	-0.4	0.4	-0.9	0.5
Illnesses of father: High blood pressure	1.0	1.2	4.7	-0.2	0.9	-0.1	2.2	1.3	-0.5
Alcohol drinker status: Never	0.7	0.9	2.5	-0.6	1.6	-0.7	-0.0	-1.3	-0.4
Ever smoked	0.5	0.9	2.0	0.8	-1.3	0.3	-1.4	0.1	1.0
Basal metabolic rate	0.5	2.8	8.3	-1.8	0.4	2.9	-0.0	-0.3	-2.2
Leg fat percentage (left)	1.1	3.9	8.4	-2.8	1.5	0.3	2.1	0.7	-2.9
Arm fat-free mass (left)	0.4	2.1	5.0	-1.6	0.1	2.2	-0.5	-0.3	-2.1
Number of operations (self-reported)	0.6	0.9	2.3	-0.4	-0.4	0.5	-1.4	-1.5	-0.6
Average weekly beer plus cider intake	0.7	1.0	2.1	-1.2	1.4	-0.5	0.7	-0.3	-1.2
Irritability	0.6	1.0	3.0	1.2	1.7	-0.5	-0.7	-0.5	0.8
Risk taking	0.8	1.2	3.0	-0.0	-0.6	-1.7	-1.0	-1.6	-0.4
Ever had prostate specific antigen (PSA) test	1.8	2.0	5.2	1.3	-1.8	0.0	-2.3	0.7	1.2
Fractured/broken bones in last 5 years	0.9	1.2	3.3	1.0	-1.5	0.2	-1.8	0.5	0.5
Age started oral contraceptive pill	0.7	0.9	3.1	0.5	0.0	-0.6	-1.8	-1.0	0.7
Diastolic blood pressure, automated reading	0.2	0.5	1.3	0.7	-0.7	-0.4	0.3	1.1	0.7
Ever depressed for a whole week	1.0	1.3	3.8	0.3	-1.9	1.0	1.1	1.0	0.6
Unable to work because of sickness or disability	1.7	2.2	8.5	-1.3	-0.5	-2.9	0.4	-1.0	-1.3
Commuting to job workplace: Cycle	0.1	0.2	0.4	-0.5	-0.6	0.3	-0.2	-0.3	-0.4
Myopia	1.0	1.4	3.0	1.7	-0.9	-1.1	0.7	1.0	1.3
Vascular/heart problems diagnosed by doctor	0.8	2.1	7.2	-0.6	-1.9	-0.9	-0.2	-2.7	-0.7
Cholesterol lowering medication	0.4	0.6	1.1	1.0	0.5	-0.3	-0.4	0.9	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.4	0.2	1.5	0.1	0.6	0.4	0.4
Pain experienced in last month	0.9	1.5	4.9	0.8	0.5	-1.4	1.0	-2.2	0.5
Supplements: Calcium	2.6	2.9	8.8	1.9	-0.8	-1.1	-3.0	0.7	1.7
Basal cell carcinoma (self-reported)	0.5	0.6	2.4	0.7	-1.6	-0.3	-0.0	0.1	0.9
Heart attack/myocardial infarction (self-reported)	1.3	1.7	7.0	-0.3	1.5	-2.6	0.1	0.7	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.3	-0.3	0.1	-0.6	0.1	-0.1	-1.1
Heart disease (siblings)	0.8	1.0	2.3	1.1	-0.5	-0.0	-1.1	1.5	1.2
Alcohol drinker status: Previous	0.5	0.6	3.0	-0.2	-1.7	-0.0	-0.1	0.5	-0.3
Pack years of smoking	0.4	0.5	1.8	0.1	0.9	0.1	-1.4	0.7	0.3
Impedance of whole body	0.1	0.3	0.9	-1.0	-0.1	-0.5	-0.7	0.3	-0.1
Leg fat mass (left)	1.2	4.7	10.6	-3.1	1.5	1.6	1.6	0.6	-3.2
Arm predicted mass (left)	0.4	2.2	5.8	-1.6	-0.1	2.4	-0.4	0.0	-2.2