Hub : Genes

ANKRD12

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0520 0.0230 1.5e-02 0.005 0.010 -0.002 0.009 0.002 8.0e-02 1.7e-02 6.5e-01 0.02500 1.7e-01
2 GTEx Testis 0.3960 0.0640 2.0e-09 0.318 NA 0.373 NA 0.363 1.0e-14 NA 1.6e-17 NA 5.6e-17
3 YFS Blood 0.0296 0.0094 2.3e-05 0.015 0.014 0.015 0.011 0.017 8.9e-06 1.6e-05 8.1e-06 0.00012 2.6e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.3 0.6 0.2 0.8 -0.4
Bipolar Disorder or Schizophrenia 2.8 6.9 10.6 1.6 2.7 -3.3
Depressed Affect (Nagel 2018) 0.1 0.2 0.6 0.0 0.8 -0.2
Depression (Nagel 2018) 1.2 1.8 5.0 -0.3 2.2 -0.6
Intelligence (Savage-Jansen 2018) 2.4 7.5 13.5 -1.8 -3.7 2.4
Neuroticism (Nagel 2018) 0.1 0.2 0.4 0.2 -0.2 0.6
Schizophrenia (2018) 4.3 8.9 15.0 1.9 2.8 -3.9
Schizophrenia vs Biploar Disorder 1.5 1.9 3.6 1.2 0.9 -1.9
Worry (Nagel 2018) 0.3 0.7 0.8 0.7 -0.9 0.9
Alzheimer’s Disease (in mother) 0.5 0.6 1.6 -1.2 0.2 -0.4
Alzheimer’s Disease (in father) 0.3 0.3 0.6 -0.1 0.8 0.5
Alzheimer’s Disease (including proxy) 0.3 0.5 1.2 -1.1 0.4 0.0
Crohns Disease (2017) 0.5 1.1 2.7 -0.3 1.6 -0.7
Irritable Bowel Disease (IBD) 0.6 1.3 2.2 -0.3 1.5 -1.3
Ulcerative Colitis (UC) 0.3 0.5 0.7 -0.7 0.5 -0.9
Major Depression (MDD) 3.1 3.8 6.8 2.6 1.1 -1.8
Reaction Time 0.1 0.2 0.4 0.4 0.6 -0.2
Verbal and Numeric Reasoning (VNR) 1.0 2.3 3.6 -1.4 -1.9 1.2
Breast Cancer 2.5 6.1 7.1 -2.7 -2.1 2.6
Ovarian Cancer 0.1 0.1 0.2 0.3 0.5 0.2
Prostate Cancer 0.8 1.1 1.9 -0.9 -1.4 0.8
Age at First Birth 2.8 4.0 5.3 1.4 2.3 -2.2
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.4 -0.2 0.4
Body Mass Index (BMI) (2010) 2.7 3.6 3.9 -1.8 -2.0 1.9
Coronary Artery Disease (CAD) 0.2 0.3 0.7 0.1 0.4 -0.8
Crohns Disease (2012) 1.3 2.0 2.7 1.0 1.6 -1.5
Mean Putamen Volume 1.5 1.8 4.4 0.3 2.1 -0.9
Fasting Glucose 0.1 0.2 0.4 -0.7 -0.2 0.1
HbA1C 1.4 1.5 3.8 -0.5 -2.0 0.7
HDL Cholesterol 0.0 0.1 0.2 0.4 -0.2 0.0
LDL Cholesterol 0.2 0.2 0.6 0.4 -0.0 -0.8
Lupus 0.7 1.0 2.7 -0.1 1.6 -0.6
Neuroticism (2016) 0.3 0.5 1.3 0.3 1.2 -0.2
Primary Biliary Cirrhosis 0.2 0.2 0.4 -0.6 -0.2 -0.5
Rheumatoid Arthritis 0.2 0.3 0.8 0.9 0.5 -0.1
Schizophrenia (2014) 2.8 6.3 9.6 1.7 2.5 -3.1
Triglycerides 0.0 0.0 0.0 0.0 -0.0 -0.1
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.1 0.6 -1.0 -0.2
Ulcerative Colitis 0.3 0.4 0.9 -0.9 0.5 -0.3
Blood Eosinophil Count 0.1 1.0 2.9 -1.7 0.0 0.4
Blood Platelet Count 0.1 0.7 1.5 0.4 1.2 -0.7
Blood Red Count 0.2 2.3 3.6 1.3 -1.9 1.3
Blood White Count 0.2 1.2 2.2 0.7 -1.5 1.0
Heel T-Score 2.6 21.0 31.5 -3.9 -5.6 4.0
BMI 1.8 10.2 14.6 -3.8 -2.5 3.1
Height 0.3 5.7 8.6 1.3 2.6 -2.9
Waist Hip Ratio (WHR) 0.1 0.7 1.1 0.4 -0.9 1.0
Systolic Blood Pressure 0.2 1.1 2.0 -0.0 -1.4 1.2
Smoking Status 2.4 5.7 7.7 -1.9 -2.4 2.8
Allergy or Eczema 1.1 2.8 5.8 0.6 2.4 -1.5
Cardiovascular Disease 0.9 3.1 5.0 -0.6 -2.0 2.2
Hypothyroidism (self reported) 0.2 0.4 0.8 0.9 -0.2 -0.5
Respiratory disease 2.9 6.5 16.6 0.9 4.1 -1.4
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.7 -0.7 -0.9 1.3
Lung FEV1/FVC ratio 0.0 0.2 0.3 0.2 -0.3 -0.6
Lung FVC 0.0 0.2 0.5 -0.3 -0.7 0.2
Neuroticism 0.3 0.8 1.4 1.2 -0.1 1.0
Chronotype (morning person) 0.0 0.1 0.1 0.1 0.3 -0.3
Hair Pigment 0.1 4.1 5.9 1.9 2.4 -1.7
Tanning 0.3 3.3 7.1 -2.7 -1.0 1.3
Hand grip strength (left) 0.3 0.9 1.4 1.2 0.0 -1.1
Number of treatments/medications taken 0.9 1.6 2.4 1.6 1.2 -0.9
Average weekly spirits intake 0.8 1.0 2.9 -1.7 0.3 -0.1
Sensitivity / hurt feelings 0.6 1.1 1.6 0.6 -1.3 1.1
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.4 -1.2 0.7 0.6
Hearing difficulty/problems: Yes 0.1 0.2 0.4 -0.6 0.5 -0.1
Relative age of first facial hair 1.0 2.0 4.9 -2.2 -1.1 0.2
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 2.6 1.5 1.6 -1.6
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.6 -0.8 0.3 -0.1
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 -0.7 0.0 -0.1
Systolic blood pressure, automated reading 0.3 0.9 1.1 -0.8 -1.1 0.9
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 5.2 -0.4 -2.3 2.0
Angina 0.6 0.7 1.4 -0.7 -0.6 1.2
Medication for hormone replacement therapy 1.1 1.2 2.4 0.4 1.6 -1.0
Vitamin and mineral supplements 1.8 2.4 4.1 -0.9 -1.5 2.0
Supplements: Zinc 2.4 2.6 5.6 0.3 1.5 -2.4
Medication: Co-codamol 0.3 0.3 0.8 -0.9 -0.2 0.3
Medication: Metformin 0.2 0.3 0.6 -0.5 0.2 0.8
Diabetes (father) 0.5 0.6 1.6 -1.3 0.1 0.4
Diabetes (mother) 1.5 2.0 3.8 0.6 1.9 -1.3
Severe depression (siblings) 1.3 1.4 3.8 0.2 1.9 -0.7
Pack years adult smoking proportion 2.7 4.2 5.5 -1.7 -2.4 2.0
Impedance of leg (right) 0.8 4.1 6.7 2.6 1.7 -1.6
Leg fat-free mass (left) 0.6 3.2 6.2 -2.5 -1.1 1.4
Trunk fat percentage 0.4 1.5 3.2 -1.8 -0.6 0.9
Hand grip strength (right) 0.4 1.1 1.8 1.1 0.3 -1.3
Townsend deprivation index at recruitment 3.1 4.3 6.6 -1.5 -2.6 2.0
Current tobacco smoking 4.7 7.7 10.4 -1.7 -3.2 3.1
Average weekly fortified wine intake 0.5 0.6 1.5 0.2 1.2 -0.4
Maternal smoking around birth 0.9 1.3 1.9 -1.2 -1.4 0.8
Fed-up feelings 0.1 0.2 0.5 0.7 -0.2 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.0 -1.0 0.8 0.4
Relative age voice broke 0.2 0.4 0.6 -0.6 -0.8 -0.3
Taking other prescription medications 0.8 1.2 3.6 1.9 -0.1 -0.3
Age when periods started (menarche) 0.1 0.2 0.5 0.7 0.1 0.3
Bilateral oophorectomy (both ovaries removed) 3.9 4.5 5.8 -2.3 -1.5 2.4
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.4 -0.1 -1.8 0.7
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.7 0.3 1.3 0.2
Qualifications: CSEs or equivalent 1.3 1.7 1.9 -1.2 -1.4 1.3
Serious illness, injury or assault to yourself 1.2 1.5 4.5 2.1 -0.0 0.0
High blood pressure 0.8 2.1 3.6 -0.9 -1.4 1.9
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.5 -0.0 0.7 -1.2
Multivitamins +/- minerals 0.7 0.9 1.5 -0.2 1.1 -1.2
Stomach or abdominal pain in last month 2.6 3.3 6.1 0.8 2.5 -1.8
Supplements: Glucosamine 0.5 0.7 0.9 0.9 0.7 -0.9
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.7 -0.5 0.3 1.9
Medication: Atenolol 1.4 1.7 3.3 -0.4 -1.3 1.8
Medication: Levothyroxine sodium 0.3 0.6 0.9 0.9 -0.9 0.3
Sitting height 0.3 2.2 4.4 0.0 1.5 -2.1
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 0.3 -0.2 -0.1
High blood pressure (mother) 0.1 0.1 0.1 -0.3 -0.2 0.4
Body mass index (BMI) 2.0 8.5 14.2 -3.8 -2.3 2.5
Impedance of leg (left) 0.8 3.9 6.1 2.5 1.5 -1.8
Leg predicted mass (left) 0.5 2.9 5.8 -2.4 -1.0 1.3
Trunk fat mass 0.5 2.1 4.5 -2.1 -0.8 1.1
Waist circumference 1.5 5.5 10.0 -3.2 -1.9 1.8
Number of incorrect matches in round 4.1 6.9 8.6 2.8 2.1 -2.9
Past tobacco smoking 0.3 0.5 1.3 1.1 0.4 -0.3
Alcohol usually taken with meals 5.2 8.5 9.5 3.1 2.8 -2.9
Nervous feelings 0.3 0.5 1.1 0.6 -1.0 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.7 0.1 0.7 0.8
Hearing difficulty/problems with background noise 0.1 0.1 0.2 -0.4 0.5 0.1
Hair/balding pattern: Pattern 2 2.8 3.6 4.9 -1.7 -1.7 2.2
Had menopause 0.1 0.1 0.3 -0.1 -0.5 0.0
Had other major operations 2.8 3.4 7.5 2.7 1.1 -1.2
Forced vital capacity (FVC) 0.5 1.8 2.5 -1.2 -1.6 1.2
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.3 9.5 -0.6 -3.1 1.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.6 -0.3 0.8 -0.5
Qualifications: None of the above 3.0 6.4 8.0 -2.1 -2.6 2.8
Financial difficulties in last 2 years 0.3 0.3 0.7 -0.6 0.0 0.8
Mouth/teeth dental problems 0.5 0.8 1.0 0.8 0.7 -1.0
Heart attack 0.3 0.4 1.0 0.5 0.1 1.0
Allergy 0.6 1.3 2.7 0.6 -1.6 0.9
Pain all over the body in last month 1.7 1.8 2.3 -1.5 -1.4 1.1
Diabetes (self-reported) 0.5 0.8 1.5 -0.7 -0.7 1.2
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 1.5 0.8 1.2 -1.1
Medication: Ramipril 1.1 1.4 2.5 1.6 1.1 -0.7
Medication: Simvastatin 1.0 1.5 3.0 -0.0 -1.7 1.2
Fluid intelligence score 0.8 1.7 4.1 -2.0 -0.8 0.6
Illnesses of siblings 0.2 0.3 0.6 0.8 -0.6 -0.1
Neuroticism score 0.7 1.4 1.8 1.1 -1.1 1.3
Weight 0.9 4.2 8.8 -3.0 -1.4 1.4
Impedance of arm (right) 1.6 7.4 8.7 3.0 2.5 -2.7
Arm fat percentage (right) 0.9 3.6 5.5 -2.3 -1.6 1.6
Trunk fat-free mass 0.4 2.1 4.2 -2.1 -1.1 1.0
Hip circumference 0.8 3.3 7.4 -2.7 -1.2 1.0
Time employed in main current job 0.6 0.7 1.1 -0.4 -0.9 1.1
Alcohol intake versus 10 years previously 0.2 0.3 0.5 -0.5 -0.7 0.6
Father’s age at death 0.3 0.3 0.7 -0.4 0.5 -0.8
Worrier / anxious feelings 0.2 0.5 0.5 0.7 -0.6 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.3 -0.0 1.5 -0.3
Falls in the last year 1.0 1.3 2.7 -1.7 -0.7 0.9
Hair/balding pattern: Pattern 3 3.6 5.4 9.0 1.8 2.0 -3.0
Number of live births 0.3 0.5 1.0 0.1 1.0 -0.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.1 -0.8 -1.0 0.3
Pulse rate 0.2 0.3 0.6 -0.2 -0.8 0.6
Happiness 1.2 1.4 2.4 -1.1 -0.7 1.6
Noisy workplace 0.8 0.9 1.6 0.2 -1.3 1.1
Qualifications: A levels/AS levels or equivalent 2.7 5.9 9.3 1.4 2.5 -3.1
Serious illness, injury or assault of a close relative in last 2 years 3.5 4.0 4.7 2.1 1.6 -2.2
Mouth/teeth dental problems: Dentures 3.5 6.0 6.3 -2.4 -2.5 2.4
Asthma 1.8 3.5 9.7 -0.4 3.1 -0.9
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 4.1 0.4 2.0 -1.4
Medication: Cholesterol lowering 0.1 0.2 0.4 0.1 -0.6 0.5
Depression (self-reported) 5.2 6.2 7.6 -2.2 -2.8 2.5
Medication: Lansoprazole 0.4 0.4 1.2 -1.1 -0.1 0.4
Prospective memory result 0.2 0.3 0.7 0.8 0.3 0.3
Lung cancer (father) 0.7 0.8 1.3 0.2 -1.1 1.0
Illnesses of mother 0.3 0.4 0.7 0.2 0.8 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.7 0.9 0.0 -0.7
Pulse wave Arterial Stiffness index 0.6 0.7 1.9 -0.3 -1.4 0.4
Impedance of arm (left) 1.3 5.9 8.0 2.8 2.3 -2.2
Arm fat mass (right) 1.2 5.0 9.5 -3.1 -1.6 1.8
Trunk predicted mass 0.4 2.2 4.4 -2.1 -1.1 1.0
Standing height 0.3 3.3 4.6 1.5 1.7 -2.1
Length of working week for main job 1.8 2.0 2.2 -1.3 -1.5 1.4
Exposure to tobacco smoke at home 0.8 0.9 1.3 -0.9 -0.7 1.2
Breastfed as a baby 1.1 1.4 2.4 0.7 1.6 -1.1
Tense / ‘highly strung’ 1.0 1.6 4.7 2.2 0.2 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 4.1 0.1 2.0 -0.4
Hair/balding pattern: Pattern 4 0.3 0.7 0.9 0.6 0.9 -1.0
Birth weight of first child 0.9 1.5 2.9 1.2 0.5 -1.7
Peak expiratory flow (PEF) 0.1 0.2 0.4 -0.6 -0.3 -0.5
Pulse wave reflection index 0.0 0.0 0.0 -0.1 -0.1 -0.1
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.0 1.0 -0.1 0.8
Loud music exposure frequency 0.1 0.1 0.1 0.2 0.4 0.2
Qualifications: O levels/GCSEs or equivalent 4.0 6.3 8.0 2.8 1.8 -2.8
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.2 -0.5 -0.4 0.5
Blood clot in the leg (DVT) 0.2 0.3 0.5 -0.5 0.7 -0.3
Medication: Paracetamol 0.4 0.6 1.8 -0.0 1.3 -0.4
Headache pain in last month 2.9 5.0 6.3 1.9 2.5 -2.3
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 2.4 0.8 1.2 -1.5
Glaucoma (self-reported) 2.5 2.9 4.5 -2.1 -0.9 1.8
Gout (self-reported) 0.2 0.3 0.7 0.1 0.8 -0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 0.9 0.9 -0.9 -0.1
Medication: Amlodipine 0.1 0.1 0.2 -0.5 0.1 0.4
Medication: Ventolin 100micrograms inhaler 1.8 2.4 5.1 1.2 2.3 -0.8
Birth weight 0.4 0.8 1.2 -0.3 1.0 -1.1
Chronic bronchitis/emphysema (mother) 1.6 1.8 2.4 -1.0 -1.4 1.6
High blood pressure (siblings) 0.3 0.4 0.9 -0.6 0.9 -0.1
Forced vital capacity (FVC), Best measure 0.1 0.5 1.1 1.0 0.1 -0.5
Body fat percentage 0.7 2.7 5.2 -2.3 -1.2 1.3
Leg fat percentage (right) 1.3 4.9 8.5 -2.9 -1.7 1.8
Arm fat-free mass (right) 0.8 3.9 7.1 -2.7 -1.4 1.6
Exposure to tobacco smoke outside home 1.3 1.7 3.5 -0.4 -1.9 1.3
Comparative body size at age 10 0.2 0.5 0.9 0.6 1.0 0.4
Number of full brothers 0.1 0.2 0.4 -0.6 -0.4 -0.0
Worry too long after embarrassment 0.5 0.8 1.2 -0.1 -1.0 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.5 0.7 0.0 0.2
Wheeze or whistling in the chest in last year 0.6 1.1 1.6 -1.2 -0.6 1.3
Number of children fathered 2.0 2.3 3.3 0.8 1.8 -1.7
Reason for reducing amount of alcohol drunk: Health precaution 7.2 8.5 8.8 3.0 2.8 -3.0
Age at first live birth 2.2 3.8 7.2 2.7 1.6 -1.4
Pulse wave peak to peak time 0.7 0.8 2.2 0.3 1.5 -0.4
Health satisfaction 0.1 0.2 0.4 -0.1 0.4 0.6
Shortness of breath walking on level ground 0.5 0.6 1.0 -0.9 1.0 0.3
Qualifications: College or University degree 3.7 11.7 12.0 3.5 3.4 -3.4
Eye problems/disorders: None of the above 0.2 0.2 0.5 0.7 0.3 0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.7 -0.4 -0.5 0.8
Emphysema/chronic bronchitis 0.7 0.8 1.1 -1.0 -0.7 0.9
Medication for pain relief, constipation, heartburn 1.6 2.8 6.9 -0.2 -2.6 1.2
Neck or shoulder pain in last month 0.7 0.9 2.2 0.4 1.5 -0.7
Medication: Blood pressure 0.7 1.2 2.1 -0.9 -0.7 1.5
Angina (self-reported) 0.7 0.9 1.7 -0.8 -0.7 1.3
Migraine (self-reported) 1.3 1.6 2.8 -0.1 1.4 -1.7
Medication: Ibuprofen 2.4 2.8 4.5 1.1 2.1 -1.7
Medication: Allopurinol 0.2 0.2 0.4 0.6 0.5 -0.3
Medication: Omeprazole 1.8 2.1 3.8 -1.4 -0.9 1.9
Medication: Seretide 50 evohaler 0.9 1.1 2.6 1.6 0.7 -0.3
Mean time to correctly identify matches 0.0 0.1 0.1 -0.1 0.3 0.3
Heart disease (mother) 0.5 0.6 1.2 -0.3 -0.6 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.7 4.4 5.9 -1.9 -1.9 2.4
Whole body fat mass 0.8 3.5 6.3 -2.5 -1.4 1.4
Leg fat mass (right) 1.2 4.8 9.0 -3.0 -1.6 1.7
Arm predicted mass (right) 0.6 2.9 5.0 -2.2 -1.4 1.3
Pulse rate, automated reading 0.3 1.0 1.6 -1.1 -1.3 0.2
Alcohol intake frequency. 0.0 0.1 0.2 -0.2 -0.5 -0.1
Comparative height size at age 10 0.8 4.2 4.6 2.1 2.1 -1.9
Number of full sisters 1.5 1.9 4.0 -2.0 -1.1 0.7
Suffer from ‘nerves’ 2.9 4.6 9.3 -0.8 -3.1 1.9
Overall health rating 0.4 0.8 1.4 0.0 -0.9 1.2
Chest pain or discomfort 0.3 0.4 0.8 0.2 0.9 0.6
Had major operations 0.8 0.9 1.1 -1.0 0.8 1.0
Age at last live birth 1.7 2.5 4.7 1.0 2.2 -1.3
Family relationship satisfaction 0.6 0.7 1.9 -0.3 -0.2 1.4
Leg pain on walking 1.1 1.4 3.5 -0.6 -0.5 1.9
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.1 -0.8 -0.9 1.0
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.4 -0.3 -0.5 1.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 -0.3 -1.1 0.4
Medication: Aspirin 0.7 0.9 2.4 -0.0 1.5 -0.6
Supplements: Vitamin C 2.5 2.9 4.3 1.9 0.9 -2.1
Knee pain experienced in last month 0.9 1.4 3.0 -1.7 0.9 -0.7
Hypertension (Self-reported) 0.4 1.2 2.1 -0.8 -0.8 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.0 -0.4 0.0
Illnesses of father: Heart disease 0.6 0.8 1.2 -0.1 -1.0 1.1
Illnesses of siblings: Diabetes 0.3 0.3 0.6 -0.6 0.8 -0.1
Smoking status: Previous 0.5 0.8 1.6 -0.2 1.2 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.1 -0.5 1.4 -0.8
Whole body fat-free mass 0.5 3.1 6.1 -2.5 -1.3 1.2
Leg fat-free mass (right) 0.6 3.0 6.2 -2.5 -1.2 1.2
Arm fat percentage (left) 1.1 4.4 6.9 -2.6 -1.7 1.8
Average weekly red wine intake 3.4 5.0 6.0 2.1 2.4 -2.1
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.2 0.8 -1.1 1.1
Mood swings 0.3 0.6 1.3 1.2 0.6 -0.0
Loneliness, isolation 0.2 0.3 0.8 -0.9 0.5 -0.0
Long-standing illness, disability or infirmity 0.5 0.8 2.4 -0.2 1.5 -0.0
Ever had bowel cancer screening 1.0 1.2 2.4 0.1 1.5 -1.1
Diabetes diagnosed by doctor 0.1 0.2 0.4 -0.4 -0.1 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.1 0.2 0.4 -0.2
Friendships satisfaction 0.0 0.0 0.1 0.1 -0.2 0.1
Qualifications: nursing, teaching 2.0 3.2 3.8 1.7 1.9 -1.7
Commuting to job workplace: Walk 1.3 1.5 4.1 0.0 -2.0 0.5
Eye problems/disorders: Cataract 0.2 0.3 0.5 -0.7 0.1 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.4 0.1 0.2 -0.6
Medication for cholesterol 0.6 0.9 2.0 -1.4 -0.6 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.8 -0.9 -0.3 0.7
Back pain experienced in last month 0.5 0.7 1.1 0.5 0.9 -1.1
Mineral and other dietary supplements 0.5 0.7 1.3 -0.7 -0.6 1.1
Breast cancer (self-reported) 1.3 1.6 3.1 1.1 0.7 -1.8
Asthma (self-reported) 1.9 3.8 10.2 0.0 3.2 -1.0
Osteoporosis (self-reported) 2.6 3.2 5.2 1.4 2.3 -1.6
Osteoarthritis (self-reported) 0.2 0.2 0.6 0.8 0.1 -0.3
Medication: Aspirin 0.6 0.7 1.8 0.1 1.3 -0.6
Medication: Gliclazide 1.3 1.4 2.6 1.6 1.0 -0.9
Illnesses of father: None of the above (group 1) 0.4 0.5 1.3 0.2 -0.3 -1.1
Smoking status: Current 3.8 6.0 8.8 -1.2 -3.0 2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 2.9 1.7 0.0 -0.8
Whole body water mass 0.5 2.9 5.5 -2.3 -1.3 1.2
Leg predicted mass (right) 0.6 3.1 6.5 -2.6 -1.1 1.2
Arm fat mass (left) 1.2 5.1 8.9 -3.0 -1.8 1.8
Number of self-reported non-cancer illnesses 0.3 0.5 1.0 -1.0 -0.0 0.6
Average weekly champagne plus white wine intake 3.4 4.6 5.1 2.1 2.3 -2.0
Miserableness 0.1 0.2 0.4 0.5 0.6 -0.1
Guilty feelings 0.4 0.5 0.8 0.9 0.9 0.2
Wears glasses or contact lenses 0.4 0.5 1.3 0.3 0.4 -1.1
Ever taken oral contraceptive pill 0.1 0.1 0.2 -0.1 -0.2 0.4
Hearing aid user 0.9 1.1 1.7 1.1 0.6 -1.3
Mother’s age at death 2.2 2.7 4.6 1.4 1.2 -2.1
Financial situation satisfaction 1.4 1.7 3.6 -0.2 -1.3 1.9
Tinnitus: Yes, now most or all of the time 1.7 1.9 4.2 1.1 2.1 -0.5
Commuting to job workplace: Public transport 2.4 2.8 3.9 2.0 1.4 -1.7
Eye problems/disorders: Glaucoma 0.8 0.9 1.5 -1.0 -0.5 1.2
Medication: Blood pressure 0.2 0.4 0.9 0.3 -0.4 1.0
Pain type(s) experienced in last month: Hip pain 1.4 1.7 2.5 1.4 1.6 -0.8
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.5 -0.4 -0.7 0.4
High cholesterol (Self-reported) 0.0 0.1 0.1 0.3 -0.2 0.2
Medication: Bendroflumethiazide 0.6 0.9 1.3 -0.7 -0.9 1.1
Medication: Paracetamol 0.9 1.4 3.5 0.6 1.9 -0.6
Medication: Lisinopril 0.4 0.5 0.7 0.6 -0.6 0.9
Medication: Atorvastatin 0.2 0.3 0.6 0.2 0.8 -0.5
Illnesses of father: High blood pressure 1.3 1.6 2.2 -1.4 -0.7 1.5
Alcohol drinker status: Never 0.8 1.0 1.3 1.2 0.7 -1.1
Ever smoked 1.2 2.2 3.9 -2.0 -1.3 1.0
Basal metabolic rate 0.7 3.6 7.2 -2.7 -1.3 1.4
Leg fat percentage (left) 1.5 5.3 9.4 -3.1 -1.9 1.7
Arm fat-free mass (left) 0.6 3.0 6.2 -2.5 -1.2 1.1
Number of operations (self-reported) 0.4 0.6 1.8 0.2 -0.3 1.3
Average weekly beer plus cider intake 3.2 4.7 6.2 -2.5 -1.8 2.1
Irritability 2.1 3.5 6.6 -0.7 -2.6 1.9
Risk taking 0.0 0.1 0.1 0.1 0.2 -0.3
Ever had prostate specific antigen (PSA) test 0.5 0.5 0.9 0.0 1.0 -0.8
Fractured/broken bones in last 5 years 0.5 0.6 1.4 0.5 0.4 1.2
Age started oral contraceptive pill 1.5 1.8 2.8 1.4 0.9 -1.7
Diastolic blood pressure, automated reading 1.1 3.4 4.7 -1.5 -2.2 1.8
Ever depressed for a whole week 1.0 1.3 3.2 0.2 1.8 -0.7
Unable to work because of sickness or disability 0.3 0.4 0.6 0.2 0.8 -0.7
Commuting to job workplace: Cycle 0.8 1.0 1.7 0.5 1.0 -1.3
Myopia 0.2 0.3 0.8 0.4 0.9 0.2
Vascular/heart problems diagnosed by doctor 1.0 2.7 4.6 1.3 1.3 -2.1
Cholesterol lowering medication 0.1 0.1 0.2 0.4 0.4 -0.1
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 2.5 -1.4 -1.0 1.6
Pain experienced in last month 2.4 4.0 7.4 -0.3 -2.7 2.1
Supplements: Calcium 4.5 5.0 5.7 2.0 2.3 -2.4
Basal cell carcinoma (self-reported) 0.3 0.3 0.5 -0.5 -0.5 0.7
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.2 0.6 0.1 1.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.8 -0.9 0.3 0.1
Heart disease (siblings) 0.8 0.9 1.4 0.9 0.8 -1.2
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.4 -0.0 -0.4
Pack years of smoking 2.0 2.9 4.0 -1.4 -2.0 1.6
Impedance of whole body 1.2 6.2 9.1 3.0 2.2 -2.2
Leg fat mass (left) 1.2 4.5 8.6 -2.9 -1.7 1.5
Arm predicted mass (left) 0.7 3.4 6.3 -2.5 -1.6 1.1