Hub : Genes

ANKRD12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0520	0.0230	1.5e-02	0.005	0.010	-0.002	0.009	0.002	8.0e-02	1.7e-02	6.5e-01	0.02500	1.7e-01
2	GTEx	Testis	0.3960	0.0640	2.0e-09	0.318	NA	0.373	NA	0.363	1.0e-14	NA	1.6e-17	NA	5.6e-17
3	YFS	Blood	0.0296	0.0094	2.3e-05	0.015	0.014	0.015	0.011	0.017	8.9e-06	1.6e-05	8.1e-06	0.00012	2.6e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.6	0.2	0.8	-0.4
Bipolar Disorder or Schizophrenia	2.8	6.9	10.6	1.6	2.7	-3.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.0	0.8	-0.2
Depression (Nagel 2018)	1.2	1.8	5.0	-0.3	2.2	-0.6
Intelligence (Savage-Jansen 2018)	2.4	7.5	13.5	-1.8	-3.7	2.4
Neuroticism (Nagel 2018)	0.1	0.2	0.4	0.2	-0.2	0.6
Schizophrenia (2018)	4.3	8.9	15.0	1.9	2.8	-3.9
Schizophrenia vs Biploar Disorder	1.5	1.9	3.6	1.2	0.9	-1.9
Worry (Nagel 2018)	0.3	0.7	0.8	0.7	-0.9	0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.6	-1.2	0.2	-0.4
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.1	0.8	0.5
Alzheimer’s Disease (including proxy)	0.3	0.5	1.2	-1.1	0.4	0.0
Crohns Disease (2017)	0.5	1.1	2.7	-0.3	1.6	-0.7
Irritable Bowel Disease (IBD)	0.6	1.3	2.2	-0.3	1.5	-1.3
Ulcerative Colitis (UC)	0.3	0.5	0.7	-0.7	0.5	-0.9
Major Depression (MDD)	3.1	3.8	6.8	2.6	1.1	-1.8
Reaction Time	0.1	0.2	0.4	0.4	0.6	-0.2
Verbal and Numeric Reasoning (VNR)	1.0	2.3	3.6	-1.4	-1.9	1.2
Breast Cancer	2.5	6.1	7.1	-2.7	-2.1	2.6
Ovarian Cancer	0.1	0.1	0.2	0.3	0.5	0.2
Prostate Cancer	0.8	1.1	1.9	-0.9	-1.4	0.8
Age at First Birth	2.8	4.0	5.3	1.4	2.3	-2.2
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.4	-0.2	0.4
Body Mass Index (BMI) (2010)	2.7	3.6	3.9	-1.8	-2.0	1.9
Coronary Artery Disease (CAD)	0.2	0.3	0.7	0.1	0.4	-0.8
Crohns Disease (2012)	1.3	2.0	2.7	1.0	1.6	-1.5
Mean Putamen Volume	1.5	1.8	4.4	0.3	2.1	-0.9
Fasting Glucose	0.1	0.2	0.4	-0.7	-0.2	0.1
HbA1C	1.4	1.5	3.8	-0.5	-2.0	0.7
HDL Cholesterol	0.0	0.1	0.2	0.4	-0.2	0.0
LDL Cholesterol	0.2	0.2	0.6	0.4	-0.0	-0.8
Lupus	0.7	1.0	2.7	-0.1	1.6	-0.6
Neuroticism (2016)	0.3	0.5	1.3	0.3	1.2	-0.2
Primary Biliary Cirrhosis	0.2	0.2	0.4	-0.6	-0.2	-0.5
Rheumatoid Arthritis	0.2	0.3	0.8	0.9	0.5	-0.1
Schizophrenia (2014)	2.8	6.3	9.6	1.7	2.5	-3.1
Triglycerides	0.0	0.0	0.0	0.0	-0.0	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	0.6	-1.0	-0.2
Ulcerative Colitis	0.3	0.4	0.9	-0.9	0.5	-0.3
Blood Eosinophil Count	0.1	1.0	2.9	-1.7	0.0	0.4
Blood Platelet Count	0.1	0.7	1.5	0.4	1.2	-0.7
Blood Red Count	0.2	2.3	3.6	1.3	-1.9	1.3
Blood White Count	0.2	1.2	2.2	0.7	-1.5	1.0
Heel T-Score	2.6	21.0	31.5	-3.9	-5.6	4.0
BMI	1.8	10.2	14.6	-3.8	-2.5	3.1
Height	0.3	5.7	8.6	1.3	2.6	-2.9
Waist Hip Ratio (WHR)	0.1	0.7	1.1	0.4	-0.9	1.0
Systolic Blood Pressure	0.2	1.1	2.0	-0.0	-1.4	1.2
Smoking Status	2.4	5.7	7.7	-1.9	-2.4	2.8
Allergy or Eczema	1.1	2.8	5.8	0.6	2.4	-1.5
Cardiovascular Disease	0.9	3.1	5.0	-0.6	-2.0	2.2
Hypothyroidism (self reported)	0.2	0.4	0.8	0.9	-0.2	-0.5
Respiratory disease	2.9	6.5	16.6	0.9	4.1	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.7	-0.7	-0.9	1.3
Lung FEV1/FVC ratio	0.0	0.2	0.3	0.2	-0.3	-0.6
Lung FVC	0.0	0.2	0.5	-0.3	-0.7	0.2
Neuroticism	0.3	0.8	1.4	1.2	-0.1	1.0
Chronotype (morning person)	0.0	0.1	0.1	0.1	0.3	-0.3
Hair Pigment	0.1	4.1	5.9	1.9	2.4	-1.7
Tanning	0.3	3.3	7.1	-2.7	-1.0	1.3
Hand grip strength (left)	0.3	0.9	1.4	1.2	0.0	-1.1
Number of treatments/medications taken	0.9	1.6	2.4	1.6	1.2	-0.9
Average weekly spirits intake	0.8	1.0	2.9	-1.7	0.3	-0.1
Sensitivity / hurt feelings	0.6	1.1	1.6	0.6	-1.3	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.4	-1.2	0.7	0.6
Hearing difficulty/problems: Yes	0.1	0.2	0.4	-0.6	0.5	-0.1
Relative age of first facial hair	1.0	2.0	4.9	-2.2	-1.1	0.2
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	2.6	1.5	1.6	-1.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	-0.8	0.3	-0.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	-0.7	0.0	-0.1
Systolic blood pressure, automated reading	0.3	0.9	1.1	-0.8	-1.1	0.9
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	5.2	-0.4	-2.3	2.0
Angina	0.6	0.7	1.4	-0.7	-0.6	1.2
Medication for hormone replacement therapy	1.1	1.2	2.4	0.4	1.6	-1.0
Vitamin and mineral supplements	1.8	2.4	4.1	-0.9	-1.5	2.0
Supplements: Zinc	2.4	2.6	5.6	0.3	1.5	-2.4
Medication: Co-codamol	0.3	0.3	0.8	-0.9	-0.2	0.3
Medication: Metformin	0.2	0.3	0.6	-0.5	0.2	0.8
Diabetes (father)	0.5	0.6	1.6	-1.3	0.1	0.4
Diabetes (mother)	1.5	2.0	3.8	0.6	1.9	-1.3
Severe depression (siblings)	1.3	1.4	3.8	0.2	1.9	-0.7
Pack years adult smoking proportion	2.7	4.2	5.5	-1.7	-2.4	2.0
Impedance of leg (right)	0.8	4.1	6.7	2.6	1.7	-1.6
Leg fat-free mass (left)	0.6	3.2	6.2	-2.5	-1.1	1.4
Trunk fat percentage	0.4	1.5	3.2	-1.8	-0.6	0.9
Hand grip strength (right)	0.4	1.1	1.8	1.1	0.3	-1.3
Townsend deprivation index at recruitment	3.1	4.3	6.6	-1.5	-2.6	2.0
Current tobacco smoking	4.7	7.7	10.4	-1.7	-3.2	3.1
Average weekly fortified wine intake	0.5	0.6	1.5	0.2	1.2	-0.4
Maternal smoking around birth	0.9	1.3	1.9	-1.2	-1.4	0.8
Fed-up feelings	0.1	0.2	0.5	0.7	-0.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.0	-1.0	0.8	0.4
Relative age voice broke	0.2	0.4	0.6	-0.6	-0.8	-0.3
Taking other prescription medications	0.8	1.2	3.6	1.9	-0.1	-0.3
Age when periods started (menarche)	0.1	0.2	0.5	0.7	0.1	0.3
Bilateral oophorectomy (both ovaries removed)	3.9	4.5	5.8	-2.3	-1.5	2.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.4	-0.1	-1.8	0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.7	0.3	1.3	0.2
Qualifications: CSEs or equivalent	1.3	1.7	1.9	-1.2	-1.4	1.3
Serious illness, injury or assault to yourself	1.2	1.5	4.5	2.1	-0.0	0.0
High blood pressure	0.8	2.1	3.6	-0.9	-1.4	1.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	-0.0	0.7	-1.2
Multivitamins +/- minerals	0.7	0.9	1.5	-0.2	1.1	-1.2
Stomach or abdominal pain in last month	2.6	3.3	6.1	0.8	2.5	-1.8
Supplements: Glucosamine	0.5	0.7	0.9	0.9	0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.7	-0.5	0.3	1.9
Medication: Atenolol	1.4	1.7	3.3	-0.4	-1.3	1.8
Medication: Levothyroxine sodium	0.3	0.6	0.9	0.9	-0.9	0.3
Sitting height	0.3	2.2	4.4	0.0	1.5	-2.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.3	-0.2	-0.1
High blood pressure (mother)	0.1	0.1	0.1	-0.3	-0.2	0.4
Body mass index (BMI)	2.0	8.5	14.2	-3.8	-2.3	2.5
Impedance of leg (left)	0.8	3.9	6.1	2.5	1.5	-1.8
Leg predicted mass (left)	0.5	2.9	5.8	-2.4	-1.0	1.3
Trunk fat mass	0.5	2.1	4.5	-2.1	-0.8	1.1
Waist circumference	1.5	5.5	10.0	-3.2	-1.9	1.8
Number of incorrect matches in round	4.1	6.9	8.6	2.8	2.1	-2.9
Past tobacco smoking	0.3	0.5	1.3	1.1	0.4	-0.3
Alcohol usually taken with meals	5.2	8.5	9.5	3.1	2.8	-2.9
Nervous feelings	0.3	0.5	1.1	0.6	-1.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	0.1	0.7	0.8
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.4	0.5	0.1
Hair/balding pattern: Pattern 2	2.8	3.6	4.9	-1.7	-1.7	2.2
Had menopause	0.1	0.1	0.3	-0.1	-0.5	0.0
Had other major operations	2.8	3.4	7.5	2.7	1.1	-1.2
Forced vital capacity (FVC)	0.5	1.8	2.5	-1.2	-1.6	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	9.5	-0.6	-3.1	1.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	-0.3	0.8	-0.5
Qualifications: None of the above	3.0	6.4	8.0	-2.1	-2.6	2.8
Financial difficulties in last 2 years	0.3	0.3	0.7	-0.6	0.0	0.8
Mouth/teeth dental problems	0.5	0.8	1.0	0.8	0.7	-1.0
Heart attack	0.3	0.4	1.0	0.5	0.1	1.0
Allergy	0.6	1.3	2.7	0.6	-1.6	0.9
Pain all over the body in last month	1.7	1.8	2.3	-1.5	-1.4	1.1
Diabetes (self-reported)	0.5	0.8	1.5	-0.7	-0.7	1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.5	0.8	1.2	-1.1
Medication: Ramipril	1.1	1.4	2.5	1.6	1.1	-0.7
Medication: Simvastatin	1.0	1.5	3.0	-0.0	-1.7	1.2
Fluid intelligence score	0.8	1.7	4.1	-2.0	-0.8	0.6
Illnesses of siblings	0.2	0.3	0.6	0.8	-0.6	-0.1
Neuroticism score	0.7	1.4	1.8	1.1	-1.1	1.3
Weight	0.9	4.2	8.8	-3.0	-1.4	1.4
Impedance of arm (right)	1.6	7.4	8.7	3.0	2.5	-2.7
Arm fat percentage (right)	0.9	3.6	5.5	-2.3	-1.6	1.6
Trunk fat-free mass	0.4	2.1	4.2	-2.1	-1.1	1.0
Hip circumference	0.8	3.3	7.4	-2.7	-1.2	1.0
Time employed in main current job	0.6	0.7	1.1	-0.4	-0.9	1.1
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.5	-0.7	0.6
Father’s age at death	0.3	0.3	0.7	-0.4	0.5	-0.8
Worrier / anxious feelings	0.2	0.5	0.5	0.7	-0.6	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	-0.0	1.5	-0.3
Falls in the last year	1.0	1.3	2.7	-1.7	-0.7	0.9
Hair/balding pattern: Pattern 3	3.6	5.4	9.0	1.8	2.0	-3.0
Number of live births	0.3	0.5	1.0	0.1	1.0	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.1	-0.8	-1.0	0.3
Pulse rate	0.2	0.3	0.6	-0.2	-0.8	0.6
Happiness	1.2	1.4	2.4	-1.1	-0.7	1.6
Noisy workplace	0.8	0.9	1.6	0.2	-1.3	1.1
Qualifications: A levels/AS levels or equivalent	2.7	5.9	9.3	1.4	2.5	-3.1
Serious illness, injury or assault of a close relative in last 2 years	3.5	4.0	4.7	2.1	1.6	-2.2
Mouth/teeth dental problems: Dentures	3.5	6.0	6.3	-2.4	-2.5	2.4
Asthma	1.8	3.5	9.7	-0.4	3.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	4.1	0.4	2.0	-1.4
Medication: Cholesterol lowering	0.1	0.2	0.4	0.1	-0.6	0.5
Depression (self-reported)	5.2	6.2	7.6	-2.2	-2.8	2.5
Medication: Lansoprazole	0.4	0.4	1.2	-1.1	-0.1	0.4
Prospective memory result	0.2	0.3	0.7	0.8	0.3	0.3
Lung cancer (father)	0.7	0.8	1.3	0.2	-1.1	1.0
Illnesses of mother	0.3	0.4	0.7	0.2	0.8	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.9	0.0	-0.7
Pulse wave Arterial Stiffness index	0.6	0.7	1.9	-0.3	-1.4	0.4
Impedance of arm (left)	1.3	5.9	8.0	2.8	2.3	-2.2
Arm fat mass (right)	1.2	5.0	9.5	-3.1	-1.6	1.8
Trunk predicted mass	0.4	2.2	4.4	-2.1	-1.1	1.0
Standing height	0.3	3.3	4.6	1.5	1.7	-2.1
Length of working week for main job	1.8	2.0	2.2	-1.3	-1.5	1.4
Exposure to tobacco smoke at home	0.8	0.9	1.3	-0.9	-0.7	1.2
Breastfed as a baby	1.1	1.4	2.4	0.7	1.6	-1.1
Tense / ‘highly strung’	1.0	1.6	4.7	2.2	0.2	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.1	0.1	2.0	-0.4
Hair/balding pattern: Pattern 4	0.3	0.7	0.9	0.6	0.9	-1.0
Birth weight of first child	0.9	1.5	2.9	1.2	0.5	-1.7
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.6	-0.3	-0.5
Pulse wave reflection index	0.0	0.0	0.0	-0.1	-0.1	-0.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.0	1.0	-0.1	0.8
Loud music exposure frequency	0.1	0.1	0.1	0.2	0.4	0.2
Qualifications: O levels/GCSEs or equivalent	4.0	6.3	8.0	2.8	1.8	-2.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.2	-0.5	-0.4	0.5
Blood clot in the leg (DVT)	0.2	0.3	0.5	-0.5	0.7	-0.3
Medication: Paracetamol	0.4	0.6	1.8	-0.0	1.3	-0.4
Headache pain in last month	2.9	5.0	6.3	1.9	2.5	-2.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.4	0.8	1.2	-1.5
Glaucoma (self-reported)	2.5	2.9	4.5	-2.1	-0.9	1.8
Gout (self-reported)	0.2	0.3	0.7	0.1	0.8	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.9	0.9	-0.9	-0.1
Medication: Amlodipine	0.1	0.1	0.2	-0.5	0.1	0.4
Medication: Ventolin 100micrograms inhaler	1.8	2.4	5.1	1.2	2.3	-0.8
Birth weight	0.4	0.8	1.2	-0.3	1.0	-1.1
Chronic bronchitis/emphysema (mother)	1.6	1.8	2.4	-1.0	-1.4	1.6
High blood pressure (siblings)	0.3	0.4	0.9	-0.6	0.9	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.5	1.1	1.0	0.1	-0.5
Body fat percentage	0.7	2.7	5.2	-2.3	-1.2	1.3
Leg fat percentage (right)	1.3	4.9	8.5	-2.9	-1.7	1.8
Arm fat-free mass (right)	0.8	3.9	7.1	-2.7	-1.4	1.6
Exposure to tobacco smoke outside home	1.3	1.7	3.5	-0.4	-1.9	1.3
Comparative body size at age 10	0.2	0.5	0.9	0.6	1.0	0.4
Number of full brothers	0.1	0.2	0.4	-0.6	-0.4	-0.0
Worry too long after embarrassment	0.5	0.8	1.2	-0.1	-1.0	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.7	0.0	0.2
Wheeze or whistling in the chest in last year	0.6	1.1	1.6	-1.2	-0.6	1.3
Number of children fathered	2.0	2.3	3.3	0.8	1.8	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	7.2	8.5	8.8	3.0	2.8	-3.0
Age at first live birth	2.2	3.8	7.2	2.7	1.6	-1.4
Pulse wave peak to peak time	0.7	0.8	2.2	0.3	1.5	-0.4
Health satisfaction	0.1	0.2	0.4	-0.1	0.4	0.6
Shortness of breath walking on level ground	0.5	0.6	1.0	-0.9	1.0	0.3
Qualifications: College or University degree	3.7	11.7	12.0	3.5	3.4	-3.4
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.7	0.3	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.7	-0.4	-0.5	0.8
Emphysema/chronic bronchitis	0.7	0.8	1.1	-1.0	-0.7	0.9
Medication for pain relief, constipation, heartburn	1.6	2.8	6.9	-0.2	-2.6	1.2
Neck or shoulder pain in last month	0.7	0.9	2.2	0.4	1.5	-0.7
Medication: Blood pressure	0.7	1.2	2.1	-0.9	-0.7	1.5
Angina (self-reported)	0.7	0.9	1.7	-0.8	-0.7	1.3
Migraine (self-reported)	1.3	1.6	2.8	-0.1	1.4	-1.7
Medication: Ibuprofen	2.4	2.8	4.5	1.1	2.1	-1.7
Medication: Allopurinol	0.2	0.2	0.4	0.6	0.5	-0.3
Medication: Omeprazole	1.8	2.1	3.8	-1.4	-0.9	1.9
Medication: Seretide 50 evohaler	0.9	1.1	2.6	1.6	0.7	-0.3
Mean time to correctly identify matches	0.0	0.1	0.1	-0.1	0.3	0.3
Heart disease (mother)	0.5	0.6	1.2	-0.3	-0.6	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	5.9	-1.9	-1.9	2.4
Whole body fat mass	0.8	3.5	6.3	-2.5	-1.4	1.4
Leg fat mass (right)	1.2	4.8	9.0	-3.0	-1.6	1.7
Arm predicted mass (right)	0.6	2.9	5.0	-2.2	-1.4	1.3
Pulse rate, automated reading	0.3	1.0	1.6	-1.1	-1.3	0.2
Alcohol intake frequency.	0.0	0.1	0.2	-0.2	-0.5	-0.1
Comparative height size at age 10	0.8	4.2	4.6	2.1	2.1	-1.9
Number of full sisters	1.5	1.9	4.0	-2.0	-1.1	0.7
Suffer from ‘nerves’	2.9	4.6	9.3	-0.8	-3.1	1.9
Overall health rating	0.4	0.8	1.4	0.0	-0.9	1.2
Chest pain or discomfort	0.3	0.4	0.8	0.2	0.9	0.6
Had major operations	0.8	0.9	1.1	-1.0	0.8	1.0
Age at last live birth	1.7	2.5	4.7	1.0	2.2	-1.3
Family relationship satisfaction	0.6	0.7	1.9	-0.3	-0.2	1.4
Leg pain on walking	1.1	1.4	3.5	-0.6	-0.5	1.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.1	-0.8	-0.9	1.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.4	-0.3	-0.5	1.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-0.3	-1.1	0.4
Medication: Aspirin	0.7	0.9	2.4	-0.0	1.5	-0.6
Supplements: Vitamin C	2.5	2.9	4.3	1.9	0.9	-2.1
Knee pain experienced in last month	0.9	1.4	3.0	-1.7	0.9	-0.7
Hypertension (Self-reported)	0.4	1.2	2.1	-0.8	-0.8	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.0	-0.4	0.0
Illnesses of father: Heart disease	0.6	0.8	1.2	-0.1	-1.0	1.1
Illnesses of siblings: Diabetes	0.3	0.3	0.6	-0.6	0.8	-0.1
Smoking status: Previous	0.5	0.8	1.6	-0.2	1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.1	-0.5	1.4	-0.8
Whole body fat-free mass	0.5	3.1	6.1	-2.5	-1.3	1.2
Leg fat-free mass (right)	0.6	3.0	6.2	-2.5	-1.2	1.2
Arm fat percentage (left)	1.1	4.4	6.9	-2.6	-1.7	1.8
Average weekly red wine intake	3.4	5.0	6.0	2.1	2.4	-2.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.2	0.8	-1.1	1.1
Mood swings	0.3	0.6	1.3	1.2	0.6	-0.0
Loneliness, isolation	0.2	0.3	0.8	-0.9	0.5	-0.0
Long-standing illness, disability or infirmity	0.5	0.8	2.4	-0.2	1.5	-0.0
Ever had bowel cancer screening	1.0	1.2	2.4	0.1	1.5	-1.1
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.4	-0.1	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.2	0.4	-0.2
Friendships satisfaction	0.0	0.0	0.1	0.1	-0.2	0.1
Qualifications: nursing, teaching	2.0	3.2	3.8	1.7	1.9	-1.7
Commuting to job workplace: Walk	1.3	1.5	4.1	0.0	-2.0	0.5
Eye problems/disorders: Cataract	0.2	0.3	0.5	-0.7	0.1	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	0.1	0.2	-0.6
Medication for cholesterol	0.6	0.9	2.0	-1.4	-0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	-0.9	-0.3	0.7
Back pain experienced in last month	0.5	0.7	1.1	0.5	0.9	-1.1
Mineral and other dietary supplements	0.5	0.7	1.3	-0.7	-0.6	1.1
Breast cancer (self-reported)	1.3	1.6	3.1	1.1	0.7	-1.8
Asthma (self-reported)	1.9	3.8	10.2	0.0	3.2	-1.0
Osteoporosis (self-reported)	2.6	3.2	5.2	1.4	2.3	-1.6
Osteoarthritis (self-reported)	0.2	0.2	0.6	0.8	0.1	-0.3
Medication: Aspirin	0.6	0.7	1.8	0.1	1.3	-0.6
Medication: Gliclazide	1.3	1.4	2.6	1.6	1.0	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.2	-0.3	-1.1
Smoking status: Current	3.8	6.0	8.8	-1.2	-3.0	2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.9	1.7	0.0	-0.8
Whole body water mass	0.5	2.9	5.5	-2.3	-1.3	1.2
Leg predicted mass (right)	0.6	3.1	6.5	-2.6	-1.1	1.2
Arm fat mass (left)	1.2	5.1	8.9	-3.0	-1.8	1.8
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	-1.0	-0.0	0.6
Average weekly champagne plus white wine intake	3.4	4.6	5.1	2.1	2.3	-2.0
Miserableness	0.1	0.2	0.4	0.5	0.6	-0.1
Guilty feelings	0.4	0.5	0.8	0.9	0.9	0.2
Wears glasses or contact lenses	0.4	0.5	1.3	0.3	0.4	-1.1
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.1	-0.2	0.4
Hearing aid user	0.9	1.1	1.7	1.1	0.6	-1.3
Mother’s age at death	2.2	2.7	4.6	1.4	1.2	-2.1
Financial situation satisfaction	1.4	1.7	3.6	-0.2	-1.3	1.9
Tinnitus: Yes, now most or all of the time	1.7	1.9	4.2	1.1	2.1	-0.5
Commuting to job workplace: Public transport	2.4	2.8	3.9	2.0	1.4	-1.7
Eye problems/disorders: Glaucoma	0.8	0.9	1.5	-1.0	-0.5	1.2
Medication: Blood pressure	0.2	0.4	0.9	0.3	-0.4	1.0
Pain type(s) experienced in last month: Hip pain	1.4	1.7	2.5	1.4	1.6	-0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	-0.4	-0.7	0.4
High cholesterol (Self-reported)	0.0	0.1	0.1	0.3	-0.2	0.2
Medication: Bendroflumethiazide	0.6	0.9	1.3	-0.7	-0.9	1.1
Medication: Paracetamol	0.9	1.4	3.5	0.6	1.9	-0.6
Medication: Lisinopril	0.4	0.5	0.7	0.6	-0.6	0.9
Medication: Atorvastatin	0.2	0.3	0.6	0.2	0.8	-0.5
Illnesses of father: High blood pressure	1.3	1.6	2.2	-1.4	-0.7	1.5
Alcohol drinker status: Never	0.8	1.0	1.3	1.2	0.7	-1.1
Ever smoked	1.2	2.2	3.9	-2.0	-1.3	1.0
Basal metabolic rate	0.7	3.6	7.2	-2.7	-1.3	1.4
Leg fat percentage (left)	1.5	5.3	9.4	-3.1	-1.9	1.7
Arm fat-free mass (left)	0.6	3.0	6.2	-2.5	-1.2	1.1
Number of operations (self-reported)	0.4	0.6	1.8	0.2	-0.3	1.3
Average weekly beer plus cider intake	3.2	4.7	6.2	-2.5	-1.8	2.1
Irritability	2.1	3.5	6.6	-0.7	-2.6	1.9
Risk taking	0.0	0.1	0.1	0.1	0.2	-0.3
Ever had prostate specific antigen (PSA) test	0.5	0.5	0.9	0.0	1.0	-0.8
Fractured/broken bones in last 5 years	0.5	0.6	1.4	0.5	0.4	1.2
Age started oral contraceptive pill	1.5	1.8	2.8	1.4	0.9	-1.7
Diastolic blood pressure, automated reading	1.1	3.4	4.7	-1.5	-2.2	1.8
Ever depressed for a whole week	1.0	1.3	3.2	0.2	1.8	-0.7
Unable to work because of sickness or disability	0.3	0.4	0.6	0.2	0.8	-0.7
Commuting to job workplace: Cycle	0.8	1.0	1.7	0.5	1.0	-1.3
Myopia	0.2	0.3	0.8	0.4	0.9	0.2
Vascular/heart problems diagnosed by doctor	1.0	2.7	4.6	1.3	1.3	-2.1
Cholesterol lowering medication	0.1	0.1	0.2	0.4	0.4	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	2.5	-1.4	-1.0	1.6
Pain experienced in last month	2.4	4.0	7.4	-0.3	-2.7	2.1
Supplements: Calcium	4.5	5.0	5.7	2.0	2.3	-2.4
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	-0.5	-0.5	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.2	0.6	0.1	1.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	-0.9	0.3	0.1
Heart disease (siblings)	0.8	0.9	1.4	0.9	0.8	-1.2
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.4	-0.0	-0.4
Pack years of smoking	2.0	2.9	4.0	-1.4	-2.0	1.6
Impedance of whole body	1.2	6.2	9.1	3.0	2.2	-2.2
Leg fat mass (left)	1.2	4.5	8.6	-2.9	-1.7	1.5
Arm predicted mass (left)	0.7	3.4	6.3	-2.5	-1.6	1.1