TWAS hub - ANKRD28

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.2610	0.0900	1.3e-03	0.010	NA	0.018	NA	0.002	1.3e-01	NA	7.5e-02	NA	2.7e-01
2	GTEx	Spleen	0.3070	0.0930	1.0e-03	0.080	NA	0.063	NA	0.067	4.4e-03	NA	1.1e-02	NA	8.3e-03
3	GTEx	Thyroid	0.1030	0.0410	1.9e-03	0.083	NA	0.052	NA	0.050	6.4e-07	NA	7.9e-05	NA	1.1e-04
4	GTEx	Whole Blood	0.0800	0.0340	5.4e-03	0.010	NA	-0.003	NA	0.002	3.5e-02	NA	8.4e-01	NA	2.0e-01
5	METSIM	Adipose	0.0616	0.0235	8.9e-05	0.050	0.025	0.012	0.033	0.042	5.3e-08	9.5e-05	5.5e-03	8.3e-06	5.3e-07
6	NTR	Blood	0.0300	0.0094	8.5e-06	0.026	0.018	0.026	0.023	0.024	4.7e-09	1.6e-06	6.1e-09	3.6e-08	2.2e-08
7	YFS	Blood	0.1042	0.0207	0.0e+00	0.086	0.092	0.089	0.096	0.097	8.5e-27	1.7e-28	1.4e-27	9.6e-30	5.2e-30

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Rheumatoid Arthritis	7.6	10.5	13.8	2.3	3.7	3.2	3.7	3.6	3.0	2.8
High blood pressure (siblings)	5.1	7.3	11.0	2.6	2.6	3.1	2.6	2.3	3.3	2.2
Sensitivity / hurt feelings	3.5	6.0	8.0	-1.2	-2.8	-1.8	-2.8	-2.6	-2.7	-2.7
Average weekly champagne plus white wine intake	3.3	4.6	5.9	-2.4	-1.5	-1.9	-2.1	-2.2	-2.3	-2.4
Happiness	3.2	3.8	5.7	-1.0	-2.2	-1.6	-2.2	-2.0	-2.0	-2.4
Blood Platelet Count	3.0	35.1	58.8	4.0	7.7	4.1	7.0	6.7	5.8	5.2
Osteoporosis (self-reported)	2.9	3.6	5.3	1.0	1.9	2.3	1.9	1.6	2.0	2.2
Diverticular disease/diverticulitis (self-reported)	2.8	3.3	8.7	-1.6	-1.1	-2.9	-1.4	-1.2	-2.4	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.3	5.5	-2.3	-1.7	-1.2	-1.8	-1.9	-1.9	-1.7
Had major operations	2.7	3.1	6.8	1.0	1.3	1.2	1.7	1.7	2.3	2.6
Financial situation satisfaction	2.7	3.4	5.2	-0.9	-2.1	-0.8	-2.0	-2.2	-1.9	-2.3
Breastfed as a baby	2.6	3.3	4.8	1.5	1.6	2.2	1.7	1.6	2.2	1.9
Pulse wave reflection index	2.4	2.9	5.5	-2.4	-1.9	-1.1	-1.9	-1.6	-1.5	-1.3
Loud music exposure frequency	2.4	2.6	4.3	-1.0	-1.6	-1.2	-1.9	-1.9	-1.3	-2.1
Illnesses of siblings: Diabetes	2.4	2.9	6.3	1.4	1.6	2.5	1.6	1.6	1.5	1.5
Chest pain or discomfort	2.3	3.4	6.1	1.2	2.1	2.5	1.8	1.8	1.7	1.6
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	6.2	-0.6	-1.2	-1.4	-2.2	-2.5	-0.7	-2.1
Tinnitus: Yes, now most or all of the time	2.2	2.5	4.2	-0.1	1.5	0.7	2.0	2.0	1.6	2.1
Neuroticism (2016)	2.1	3.1	5.9	-0.8	-1.8	-0.5	-2.1	-2.3	-1.4	-2.4
Pulse wave Arterial Stiffness index	2.1	2.4	3.5	-1.6	-1.9	-1.6	-1.6	-1.4	-1.5	-1.3
Medication for pain relief, constipation, heartburn	2.1	3.6	5.7	0.3	2.4	1.2	2.3	2.1	1.7	2.4
Triglycerides	2.0	3.2	5.8	2.4	1.7	1.2	1.9	2.0	1.4	1.7
Hearing difficulty/problems: Yes	2.0	3.1	6.1	1.9	1.0	2.5	1.7	1.9	1.5	1.5
Illnesses of siblings	2.0	2.8	6.4	-1.8	-1.2	-2.5	-1.2	-0.9	-2.3	-1.1
Irritability	2.0	3.4	6.0	-1.1	-1.9	-2.5	-1.8	-1.6	-1.6	-2.1
Ever had prostate specific antigen (PSA) test	2.0	2.3	3.5	-0.9	-1.6	-1.0	-1.9	-1.7	-1.6	-1.5
Cardiovascular Disease	1.9	6.3	7.9	2.0	2.3	2.5	2.7	2.8	2.6	2.6
Diabetes (mother)	1.9	2.5	6.4	2.5	1.1	2.5	0.9	0.7	1.5	-0.0
Commuting to job workplace: Cycle	1.9	2.2	3.3	-0.6	1.5	1.0	1.6	1.8	1.7	1.8
High blood pressure (mother)	1.8	2.5	4.0	2.0	1.8	1.0	1.7	1.7	1.4	1.4
Pulse wave peak to peak time	1.8	2.1	3.1	1.5	1.8	1.5	1.4	1.2	1.4	1.3
Handedness (chirality/laterality): Left-handed	1.8	2.1	3.3	0.8	1.0	1.6	1.4	1.5	1.8	1.7
Alcohol drinker status: Previous	1.8	2.0	2.9	0.5	1.5	1.7	1.6	1.5	1.4	1.4
Type 2 Diabetes (T2D) (2012)	1.7	2.0	4.5	1.3	1.4	2.1	1.7	1.4	0.5	0.8
Maternal smoking around birth	1.6	2.4	3.8	-0.0	-1.9	-1.8	-1.6	-1.6	-1.7	-1.4
Exposure to tobacco smoke outside home	1.6	2.1	3.7	0.6	1.5	1.9	1.4	1.2	1.9	1.3
Medication: Gliclazide	1.6	1.8	3.5	-1.1	-1.9	-1.3	-1.3	-1.1	-1.2	-1.2
Stomach or abdominal pain in last month	1.5	1.9	4.4	-1.2	-2.1	-0.6	-1.4	-1.4	-1.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.5	-0.8	-1.5	-1.4	-1.6	-1.5	-1.3	-1.4
Medication: Ibuprofen	1.5	1.8	2.5	-0.6	-1.3	-1.1	-1.6	-1.4	-1.5	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.7	-1.6	-1.1	-1.1	-1.3	-1.1	-1.3	-1.6
Schizophrenia vs Biploar Disorder	1.4	1.8	2.6	-1.2	-1.3	-1.6	-1.5	-1.5	-0.8	-1.3
Ovarian Cancer	1.4	1.9	3.8	1.0	1.9	1.0	1.6	1.5	1.2	1.1
Neuroticism score	1.4	2.9	6.4	-0.3	-1.8	-1.0	-2.0	-1.8	-1.6	-2.5
Alcohol intake versus 10 years previously	1.4	2.0	3.1	1.7	1.1	1.4	1.5	1.8	1.1	1.3
Tense / ‘highly strung’	1.4	2.3	6.5	1.1	-1.2	-0.1	-1.7	-1.8	-0.9	-2.5
Medication: Levothyroxine sodium	1.3	2.2	3.4	-1.0	-1.9	-1.5	-1.6	-1.4	-1.5	-1.5
Illnesses of mother	1.3	1.6	2.2	-1.5	-1.2	-1.4	-1.2	-1.1	-1.2	-1.3
Worry too long after embarrassment	1.3	2.2	2.8	-1.1	-1.7	-1.7	-1.7	-1.4	-1.4	-1.4
Ever had bowel cancer screening	1.3	1.5	2.6	-1.3	-1.3	0.2	-1.2	-1.1	-1.3	-1.6
Myopia	1.3	1.8	3.6	0.8	1.6	1.4	1.1	0.7	1.9	1.6
Supplements: Calcium	1.3	1.4	3.5	0.4	0.7	1.9	0.7	0.5	1.5	1.5
Relative age voice broke	1.2	1.8	3.0	1.6	1.7	0.1	1.3	1.3	1.7	1.1
Medication: Seretide 50 evohaler	1.2	1.4	2.4	-0.3	1.6	0.8	1.3	1.4	1.2	1.0
Overall health rating	1.2	2.6	5.0	0.6	-2.1	-0.8	-1.6	-1.4	-1.9	-2.2
Guilty feelings	1.2	1.7	2.8	-1.1	-1.2	-1.0	-1.6	-1.4	-1.2	-1.7
Commuting to job workplace: Public transport	1.2	1.5	3.1	0.3	1.8	1.4	1.1	1.0	1.4	1.0
Heart disease (siblings)	1.2	1.4	3.4	0.6	-1.8	-0.4	-1.5	-1.5	-0.5	-1.2
Medication: Metformin	1.1	1.6	2.8	-1.0	-1.3	-1.7	-0.9	-0.8	-1.4	-1.4
Suffer from ‘nerves’	1.1	1.8	4.4	2.1	1.3	1.8	1.0	1.1	0.8	0.3
Illnesses of father: None of the above (group 1)	1.1	1.3	4.2	2.0	1.3	1.0	1.1	1.1	0.3	0.1
Neuroticism (Nagel 2018)	1.0	2.4	5.2	0.4	-1.7	-0.7	-1.9	-1.7	-1.3	-2.3
Supplements: Glucosamine	1.0	1.4	3.3	0.8	-1.2	-0.8	-1.6	-1.8	-0.6	-0.6
Waist circumference	1.0	3.8	20.7	4.5	-0.4	2.0	0.6	0.7	0.2	-0.7
Lung cancer (father)	1.0	1.2	2.6	0.1	-0.8	-0.8	-1.0	-1.1	-1.3	-1.6
Length of working week for main job	1.0	1.1	3.1	1.8	0.8	0.9	0.9	1.0	0.9	0.8
Qualifications: College or University degree	1.0	3.3	5.3	-1.2	2.3	0.7	1.8	1.8	2.2	2.1
Mean time to correctly identify matches	1.0	1.8	2.3	-0.4	-1.5	-1.4	-1.4	-1.4	-1.5	-1.4
Medication: Aspirin	1.0	1.4	2.7	-0.0	-1.6	-0.7	-1.5	-1.4	-0.7	-1.3
Osteoarthritis (self-reported)	1.0	1.2	2.9	0.4	-1.2	0.4	-1.4	-1.7	-0.7	-1.3
Schizophrenia (2014)	0.9	2.1	3.3	-1.8	-1.3	-1.2	-1.2	-1.1	-1.8	-1.5
Current tobacco smoking	0.9	1.5	3.2	-0.9	-1.1	-0.9	-1.4	-1.4	-1.8	-0.9
Pain all over the body in last month	0.9	0.9	2.0	-0.2	0.5	1.0	1.1	1.2	0.6	1.4
Arm fat mass (right)	0.9	3.6	17.7	4.2	0.1	2.2	1.0	1.0	0.7	-0.1
Peak expiratory flow (PEF)	0.9	2.0	3.3	-0.2	1.4	0.9	1.7	1.7	1.5	1.8
Arm fat percentage (left)	0.9	3.6	16.9	4.1	0.0	2.4	1.1	1.1	0.6	-0.2
Miserableness	0.9	1.5	4.2	2.0	0.5	1.7	0.6	0.6	1.5	0.2
Hearing aid user	0.9	1.0	1.5	-0.7	-1.2	-1.0	-1.1	-1.0	-0.9	-0.8
Medication: Bendroflumethiazide	0.9	1.4	2.1	1.3	1.4	1.3	1.1	0.8	1.4	0.7
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.9	-2.2	-1.1	-1.2	-1.5	-1.8	-1.7	-1.3
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.2	1.4	1.8	1.4	1.1	0.8	1.7	1.1
Fasting Glucose	0.8	1.0	1.7	1.3	0.7	-0.1	1.0	1.1	1.0	1.1
Systolic Blood Pressure	0.8	3.8	6.4	2.5	1.9	1.4	2.0	2.3	1.6	1.8
Multivitamins +/- minerals	0.8	1.1	1.9	-1.4	-0.7	-1.0	-1.0	-1.3	-1.2	-0.3
Arm fat percentage (right)	0.8	3.1	15.4	3.9	-0.2	2.1	0.8	0.8	0.4	-0.4
Birth weight	0.8	1.8	3.8	-0.4	-0.9	-2.0	-1.4	-1.7	-1.2	-1.2
Body fat percentage	0.8	3.2	17.0	4.1	-0.2	1.9	0.6	0.6	0.4	-0.6
Eye problems/disorders: None of the above	0.8	1.0	2.6	-0.5	-0.2	-0.4	-1.3	-1.6	-0.4	-1.3
Whole body fat mass	0.8	3.4	18.4	4.3	-0.2	2.0	0.6	0.6	0.5	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.0	-0.9	-1.7	-0.0	-1.4	-1.1	-0.6	-1.4
Breast cancer (self-reported)	0.8	0.9	1.5	0.2	1.2	0.8	0.9	0.8	1.1	1.2
Arm fat mass (left)	0.8	3.2	17.2	4.2	-0.2	2.0	0.7	0.7	0.4	-0.5
Medication: Lisinopril	0.8	1.1	2.5	0.1	1.1	0.0	1.4	1.6	0.8	1.2
Illnesses of father: High blood pressure	0.8	1.0	2.0	0.4	0.9	-0.3	1.0	1.2	1.1	1.4
Breast Cancer	0.7	1.8	3.0	0.5	1.5	0.1	1.5	1.7	1.4	1.7
Ulcerative Colitis	0.7	1.0	1.6	0.5	-1.3	-0.5	-1.2	-1.1	-1.2	-1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	4.5	2.1	0.2	1.0	0.6	0.3	0.5	0.3
Trunk fat percentage	0.7	2.8	15.7	4.0	-0.2	1.7	0.4	0.4	0.3	-0.5
Average weekly fortified wine intake	0.7	0.9	1.8	0.7	-0.8	-0.0	-1.1	-1.0	-1.1	-1.3
Serious illness, injury or assault to yourself	0.7	0.9	1.9	-0.1	-1.3	-1.2	-0.5	-0.2	-1.4	-0.9
High blood pressure	0.7	2.1	5.5	2.4	0.9	0.8	1.4	1.6	1.4	1.1
Medication: Atenolol	0.7	0.9	2.7	1.6	-0.2	1.4	0.2	0.5	1.1	0.2
Trunk fat mass	0.7	2.9	16.4	4.0	-0.2	1.8	0.5	0.4	0.4	-0.4
Hip circumference	0.7	3.1	16.8	4.1	0.1	1.9	0.7	0.6	0.5	-0.0
Time employed in main current job	0.7	0.8	2.9	-0.0	-0.5	-1.7	-0.5	-0.5	-1.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.4	-1.1	-1.6	-1.2	-1.1	-0.8	-1.3	-0.7
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.3	1.1	0.5	1.1	0.8	0.7	0.8	1.1
Leg fat mass (right)	0.7	2.7	15.3	3.9	-0.5	1.6	0.5	0.5	0.1	-0.7
Hypertension (Self-reported)	0.7	1.8	6.0	2.5	0.9	0.7	1.2	1.5	1.0	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.3	-1.5	-0.8	-0.6	-0.9	-1.2	-0.3	-0.2
Eye problems/disorders: Cataract	0.7	0.9	2.1	0.8	0.4	1.5	0.8	0.8	0.7	1.1
Medication: Atorvastatin	0.7	0.8	2.5	1.6	-0.8	1.1	0.1	0.3	-0.8	-0.7
Leg fat mass (left)	0.7	2.9	16.6	4.1	-0.5	1.6	0.5	0.5	0.2	-0.6
Depressed Affect (Nagel 2018)	0.6	1.2	2.3	0.6	-1.3	-0.5	-1.2	-1.3	-0.6	-1.5
Coronary Artery Disease (CAD)	0.6	0.7	1.2	-0.6	-1.0	-0.3	-0.9	-0.8	-1.1	-0.9
Hypothyroidism (self reported)	0.6	1.3	2.4	-0.9	-1.6	-1.2	-1.1	-0.9	-1.4	-0.7
Average weekly spirits intake	0.6	0.8	4.8	2.2	-0.3	-0.2	0.0	0.1	-0.4	-0.4
Fed-up feelings	0.6	1.1	2.1	-0.3	-1.0	-0.9	-1.2	-1.2	-1.0	-1.4
Body mass index (BMI)	0.6	2.8	15.7	4.0	-0.5	1.5	0.6	0.6	0.2	-0.5
Past tobacco smoking	0.6	1.2	1.9	-0.9	-1.1	-1.4	-1.3	-1.0	-1.1	-0.6
Nervous feelings	0.6	1.1	3.8	0.2	-0.8	-0.2	-1.1	-1.2	-0.9	-2.0
Had menopause	0.6	0.8	4.0	2.0	-0.3	1.0	-0.2	-0.4	0.0	-0.5
Weight	0.6	2.7	14.8	3.9	-0.1	1.9	0.6	0.5	0.4	-0.1
Father’s age at death	0.6	0.8	2.1	1.4	0.5	1.5	0.6	0.6	0.5	0.5
Prospective memory result	0.6	0.7	0.9	0.7	-0.8	-1.0	-0.9	-0.9	-0.9	-0.8
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.3	0.3	0.8	0.9	0.9	0.9	1.1	0.2
Leg fat percentage (right)	0.6	2.3	11.4	3.4	-0.8	1.4	0.1	0.1	-0.3	-1.3
Medication: Blood pressure	0.6	1.1	6.5	2.5	0.2	0.4	0.5	0.9	0.4	0.4
Alcohol intake frequency.	0.6	1.3	2.8	1.0	0.6	1.7	1.2	1.2	0.8	1.2
Medication: Aspirin	0.6	0.7	1.5	0.6	-1.2	-0.3	-1.1	-0.9	-0.5	-1.0
Medication: Blood pressure	0.6	1.2	2.8	0.7	0.8	0.8	1.1	1.3	1.7	1.0
Leg fat percentage (left)	0.6	2.2	12.3	3.5	-0.7	1.3	0.2	0.3	-0.2	-1.1
Cholesterol lowering medication	0.6	0.9	2.1	1.4	0.5	1.5	0.5	0.3	1.1	0.3
Depression (Nagel 2018)	0.5	0.7	1.7	-0.7	-0.7	-0.1	-1.1	-1.1	-0.3	-1.3
Worry (Nagel 2018)	0.5	1.1	4.3	2.1	0.1	1.6	-0.2	-0.1	0.2	-1.0
Bipolar Disorder (2011)	0.5	0.5	1.2	-0.9	1.1	-0.1	0.8	0.8	-0.3	0.4
LDL Cholesterol	0.5	0.8	1.7	1.3	0.5	-0.2	0.8	1.1	0.9	1.1
Neuroticism	0.5	1.2	3.1	0.7	-1.2	0.1	-1.2	-0.9	-0.9	-1.7
Townsend deprivation index at recruitment	0.5	0.7	1.7	-0.9	0.4	1.3	1.0	1.0	0.6	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.5	1.2	1.1	1.1	0.6	0.5	1.0	0.1
Had other major operations	0.5	0.6	3.6	-1.9	-0.5	0.1	-0.3	-0.2	0.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	-0.0	0.6	-0.0	1.1	1.1	0.6	1.1
Medication: Paracetamol	0.5	0.9	1.6	-0.6	-1.0	-0.3	-1.1	-1.2	-0.6	-1.3
Medication: Omeprazole	0.5	0.6	1.4	0.2	-0.6	-1.2	-0.6	-0.8	-0.9	-0.7
Pulse rate, automated reading	0.5	1.6	3.0	0.4	1.3	0.2	1.7	1.7	1.7	1.0
Smoking status: Previous	0.5	0.7	1.1	0.9	0.7	1.1	1.0	0.8	0.8	0.2
Mineral and other dietary supplements	0.5	0.7	2.1	-1.0	0.7	-0.0	1.1	1.4	-0.2	0.3
Smoking status: Current	0.5	0.7	1.7	-0.6	-0.5	-0.4	-1.0	-1.1	-1.3	-0.6
Alcohol drinker status: Never	0.5	0.6	1.4	-1.2	-0.8	0.0	-0.7	-0.7	-0.7	-0.6
Pain experienced in last month	0.5	0.8	1.6	-0.2	-0.5	-1.0	-1.1	-1.3	-0.9	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	-0.6	-0.8	-0.7	-0.4	-0.5	-1.3	-0.9
Schizophrenia (2018)	0.4	0.7	2.0	-1.4	-0.3	-0.7	-0.3	-0.2	-1.3	-0.8
Alzheimer’s Disease (in mother)	0.4	0.4	1.5	1.2	-0.7	0.7	-0.4	-0.4	-0.1	-0.2
Reaction Time	0.4	0.7	1.6	-0.6	-0.7	-1.3	-0.6	-0.6	-1.3	-0.4
Body Mass Index (BMI) (2010)	0.4	0.6	0.9	0.7	0.7	0.8	1.0	1.0	0.2	0.7
Blood White Count	0.4	2.8	5.9	2.4	1.4	1.3	1.8	2.0	1.2	1.3
Heel T-Score	0.4	3.1	8.6	2.9	1.6	0.1	1.8	2.0	1.4	1.0
BMI	0.4	2.6	11.7	3.4	-0.1	1.8	1.0	1.2	0.7	0.2
Number of treatments/medications taken	0.4	0.8	2.1	-0.4	-1.5	-0.4	-1.1	-0.9	-0.9	-0.6
Ever had hysterectomy (womb removed)	0.4	0.4	1.0	-0.7	-0.4	0.5	-0.6	-1.0	-0.5	-0.7
Vitamin and mineral supplements	0.4	0.6	1.2	0.2	0.7	0.7	0.8	0.9	1.1	0.4
Leg fat-free mass (left)	0.4	2.2	9.6	3.1	0.4	1.6	0.8	0.7	1.0	0.9
Age when periods started (menarche)	0.4	0.9	3.2	-1.8	-0.3	-0.3	-0.8	-0.9	-0.4	-1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-0.2	-0.6	0.7	-0.7	-0.5	-0.3	-1.0
Chronic bronchitis/emphysema (father)	0.4	0.5	2.5	-1.6	-0.4	-0.3	-0.5	-0.7	-0.0	-0.3
Leg predicted mass (left)	0.4	2.2	10.0	3.2	0.4	1.6	0.8	0.7	0.9	0.9
Alcohol usually taken with meals	0.4	0.6	2.1	-1.5	-0.3	-0.2	-0.2	0.1	-1.2	-0.9
Hearing difficulty/problems with background noise	0.4	0.6	1.9	0.1	0.7	1.4	0.8	0.9	0.4	0.2
Qualifications: None of the above	0.4	0.8	1.6	1.0	-1.3	1.3	-0.3	-0.1	-1.0	-0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	0.9	0.6	0.1	0.7	0.9	1.0	0.7
Noisy workplace	0.4	0.5	2.1	0.7	-0.5	-1.4	-0.3	-0.4	-0.6	-0.4
Arm fat-free mass (right)	0.4	2.1	9.4	3.1	0.3	1.5	0.7	0.8	1.1	0.8
Wheeze or whistling in the chest in last year	0.4	0.8	2.9	-1.7	-1.0	-0.2	-0.6	-0.6	-0.7	-0.7
Migraine (self-reported)	0.4	0.5	0.9	-0.5	-1.0	-0.7	-0.8	-0.7	-0.9	-0.5
Heart disease (mother)	0.4	0.5	0.9	0.9	0.9	0.3	0.7	0.4	0.7	0.9
Arm predicted mass (right)	0.4	2.1	8.9	3.0	0.3	1.4	0.8	0.8	1.2	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.2	-0.5	-0.8	-1.1	-0.6	-0.7	-0.0	-0.3
Supplements: Vitamin C	0.4	0.5	1.0	0.2	-0.6	-0.7	-0.8	-0.8	-1.0	-0.2
Leg fat-free mass (right)	0.4	2.2	8.9	3.0	0.5	1.5	0.9	0.8	1.0	1.1
Friendships satisfaction	0.4	0.5	1.1	-0.5	-1.1	-0.6	-0.7	-0.8	0.1	-0.9
Back pain experienced in last month	0.4	0.5	1.6	1.3	0.5	0.4	0.7	0.7	0.8	0.2
Leg predicted mass (right)	0.4	2.0	8.7	2.9	0.4	1.4	0.8	0.7	1.0	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.4	-1.2	-1.1	-0.3	-0.4	-0.2	-0.7	-0.8
Basal metabolic rate	0.4	2.1	9.1	3.0	0.4	1.6	0.8	0.8	0.9	0.8
Arm fat-free mass (left)	0.4	2.2	10.8	3.3	0.3	1.6	0.6	0.5	1.1	0.5
Risk taking	0.4	0.6	1.7	-0.3	-1.3	-0.9	-0.6	-0.5	-0.8	-0.3
Diastolic blood pressure, automated reading	0.4	1.2	4.0	2.0	0.9	0.4	1.0	1.0	1.2	0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	0.5	-0.7	-1.0	-0.7	-0.9	-0.5	-0.3
Pack years of smoking	0.4	0.6	1.2	0.7	-1.1	-0.6	-0.8	-0.8	-0.7	-0.6
Arm predicted mass (left)	0.4	1.9	9.5	3.1	0.3	1.4	0.6	0.6	1.0	0.6
Ulcerative Colitis (UC)	0.3	0.6	0.9	0.4	-1.0	-0.3	-0.9	-0.8	-1.0	-0.9
Crohns Disease (2012)	0.3	0.4	2.0	-1.4	-0.1	0.2	-0.4	-0.4	-0.6	-0.3
Mean Putamen Volume	0.3	0.4	0.8	0.3	0.9	-0.0	0.7	0.9	-0.2	0.5
Lupus	0.3	0.5	1.2	0.7	0.4	0.3	1.0	1.1	0.0	0.6
Smoking Status	0.3	0.8	1.4	0.6	1.1	0.9	1.2	1.0	0.3	0.7
Lung FEV1/FVC ratio	0.3	1.4	3.0	-1.7	-1.1	-0.3	-0.9	-0.9	-1.7	-1.0
Systolic blood pressure, automated reading	0.3	1.0	6.2	2.5	0.3	0.6	0.4	0.5	0.1	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.7	1.3	-0.3	-0.4	-0.3	-0.3	-0.0	0.5
Angina	0.3	0.4	1.9	1.4	-0.6	0.0	-0.4	-0.2	0.2	-0.3
Pack years adult smoking proportion	0.3	0.4	0.8	0.8	-0.9	-0.5	-0.6	-0.5	-0.7	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	-0.6	-0.2	0.3	-0.7	-0.6	-0.0	-1.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.2	1.1	-0.3	-0.3	-0.5	-0.5	0.5	0.3
Allergy	0.3	0.6	2.6	1.6	0.0	-0.3	0.4	0.7	0.7	0.7
Diabetes (self-reported)	0.3	0.4	1.9	1.4	-0.5	-0.8	-0.3	-0.1	-0.4	-0.3
Impedance of arm (right)	0.3	1.4	4.2	-2.0	-0.2	-1.1	-1.1	-1.3	-1.0	-0.6
Worrier / anxious feelings	0.3	0.5	0.9	-0.5	-0.3	-1.0	-0.9	-0.7	-0.7	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.9	0.3	-0.7	-0.5	-0.8	-0.7	-0.7	-0.9
Falls in the last year	0.3	0.4	1.5	0.6	-1.2	-0.1	-0.1	0.0	-0.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.6	-0.9	1.2	-0.2	0.6	0.3	0.8	1.0
Mouth/teeth dental problems: Dentures	0.3	0.6	1.3	0.1	-1.0	0.4	-0.8	-0.9	-0.3	-1.1
Depression (self-reported)	0.3	0.3	0.7	-0.4	0.8	0.5	0.1	-0.0	0.8	0.6
Medication: Lansoprazole	0.3	0.3	0.6	-0.1	-0.6	0.5	-0.6	-0.7	0.8	0.1
Hair/balding pattern: Pattern 4	0.3	0.6	1.5	0.9	-0.9	-0.3	-0.8	-0.8	0.1	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	0.5	-0.6	-0.7	-0.1	-0.0	0.8	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	2.2	-1.5	-0.4	-0.9	-0.5	-0.7	-0.4	-0.2
Medication: Amlodipine	0.3	0.5	1.2	1.1	0.3	0.7	0.5	0.7	0.7	0.4
Shortness of breath walking on level ground	0.3	0.3	0.8	0.8	0.4	0.9	0.3	0.3	0.5	-0.0
Emphysema/chronic bronchitis	0.3	0.3	1.4	-0.5	-0.3	0.0	-0.4	-0.6	-0.0	-1.2
Angina (self-reported)	0.3	0.4	2.0	1.4	-0.6	0.1	-0.4	-0.3	0.3	-0.2
Whole body fat-free mass	0.3	1.7	6.9	2.6	0.4	1.3	0.8	0.7	1.0	1.0
Mood swings	0.3	0.5	1.3	0.4	-0.9	-0.2	-0.7	-0.8	-0.4	-1.1
Qualifications: nursing, teaching	0.3	0.4	2.6	-1.6	-0.1	-0.3	-0.2	-0.3	0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.2	1.1	-0.2	0.7	0.1	0.4	0.0	-0.5
Whole body water mass	0.3	1.6	6.9	2.6	0.3	1.3	0.6	0.6	1.0	0.8
Wears glasses or contact lenses	0.3	0.4	0.9	-0.3	0.8	0.5	0.3	0.3	1.0	0.8
Ever taken oral contraceptive pill	0.3	0.4	0.9	-0.9	1.0	0.1	0.6	0.6	0.4	0.2
Mother’s age at death	0.3	0.4	0.9	-0.7	0.4	-0.8	0.4	0.3	-0.9	-0.1
Eye problems/disorders: Glaucoma	0.3	0.3	1.6	0.5	-0.1	1.2	0.2	0.5	-0.0	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	0.3	-0.7	-0.7	-0.8	-1.2	-0.1	-0.2
Ever smoked	0.3	0.5	1.6	0.2	0.7	1.3	0.8	0.5	0.8	0.2
Alzheimer’s Disease (including proxy)	0.2	0.2	0.9	1.0	-0.5	0.4	-0.2	-0.3	0.2	0.1
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	0.0	-0.5	0.5	-0.8	-0.8	-1.0	-0.8
Age at First Birth	0.2	0.3	0.6	-0.8	0.7	-0.7	0.4	0.3	0.2	0.6
HbA1C	0.2	0.2	1.1	1.1	0.4	-0.1	0.2	-0.0	0.1	0.4
Primary Biliary Cirrhosis	0.2	0.3	1.2	-0.3	-0.3	-1.1	-0.4	-0.4	-0.0	-0.4
Waist Hip Ratio (WHR)	0.2	1.1	5.0	2.2	-0.3	1.1	0.4	0.6	-0.2	-0.9
Allergy or Eczema	0.2	0.6	1.2	-0.6	1.1	0.8	0.6	0.4	0.4	1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.8	1.4	-0.2	0.1	0.3	0.5	0.6	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.6	0.2	0.8	-0.3	-0.6	0.4	-0.6
Impedance of leg (right)	0.2	0.8	3.1	-1.8	0.1	-0.9	-0.7	-0.7	-0.5	-0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.6	-0.6	0.1	-0.3	-0.5	-0.6	-0.0
Qualifications: CSEs or equivalent	0.2	0.2	1.2	-0.0	-0.1	-1.1	-0.3	-0.1	0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.0	-1.4	0.2	0.1	-0.3	-0.6	-0.3	0.0
Sitting height	0.2	1.2	2.2	0.6	-0.9	0.2	-1.4	-1.5	-1.2	-1.1
Impedance of leg (left)	0.2	0.8	2.6	-1.6	0.1	-1.2	-0.6	-0.6	-0.5	-0.5
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.7	-0.3	-0.7	-0.5	-0.3	-0.8	-0.2
Mouth/teeth dental problems	0.2	0.2	1.0	-0.5	0.3	-1.0	0.2	0.1	-0.5	-0.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	-0.1	-0.4	-0.6	-0.5	-0.4	-0.9	-0.3
Fluid intelligence score	0.2	0.4	1.5	0.5	1.2	1.0	0.5	0.2	0.2	0.1
Trunk fat-free mass	0.2	0.9	3.7	1.9	0.3	0.9	0.5	0.5	0.8	0.8
Pulse rate	0.2	0.3	0.7	0.8	-0.0	-0.8	0.5	0.4	0.5	-0.4
Trunk predicted mass	0.2	1.0	4.0	2.0	0.3	1.0	0.5	0.5	0.8	0.8
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.7	0.1	0.5	0.4	0.5	0.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.2	0.5	0.7	0.3	0.1	0.9	0.6
Birth weight of first child	0.2	0.3	1.2	1.1	0.0	-0.4	-0.1	-0.2	0.5	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.1	0.9	-0.2	0.2	-0.0	0.9	0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	0.3	0.4	0.7	0.4	0.6	0.0	0.8
Blood clot in the leg (DVT)	0.2	0.3	0.9	-0.4	-0.5	-0.4	-0.2	-0.2	-0.9	-0.6
Headache pain in last month	0.2	0.3	0.6	0.6	0.7	0.3	0.6	0.8	0.7	0.3
Number of full brothers	0.2	0.3	0.6	0.6	-0.8	-0.2	-0.2	-0.1	-0.7	-0.6
Number of children fathered	0.2	0.2	0.5	0.6	-0.7	0.7	-0.2	-0.1	0.0	0.1
Age at first live birth	0.2	0.4	1.8	-0.6	-0.1	-1.4	-0.3	-0.1	-0.8	0.0
Neck or shoulder pain in last month	0.2	0.2	0.8	-0.7	-0.9	0.5	-0.0	0.1	0.0	0.2
Leg pain on walking	0.2	0.3	0.9	-0.2	-1.0	-0.2	-0.4	-0.5	-0.4	-0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.0	1.0	-0.4	0.1	-0.2	-0.4	0.6	0.0
Average weekly red wine intake	0.2	0.3	1.1	-1.1	-0.4	-0.2	-0.6	-0.6	-0.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.7	-0.2	-0.9	-0.1	-0.0	0.5	-0.3
Commuting to job workplace: Walk	0.2	0.3	0.9	0.1	-0.4	0.9	-0.4	-0.3	-0.4	-0.6
Medication: Paracetamol	0.2	0.4	1.0	-0.2	-0.6	0.3	-0.6	-0.8	-0.1	-1.0
Number of operations (self-reported)	0.2	0.3	0.7	-0.9	-0.7	-0.1	-0.3	-0.4	0.3	0.7
Average weekly beer plus cider intake	0.2	0.3	1.5	-1.2	-0.2	-0.5	-0.1	-0.2	-0.2	0.2
Fractured/broken bones in last 5 years	0.2	0.2	1.3	1.1	0.3	0.0	0.3	0.2	0.5	0.1
Age started oral contraceptive pill	0.2	0.3	1.1	0.6	1.1	0.4	0.3	0.1	0.3	-0.1
Unable to work because of sickness or disability	0.2	0.3	0.7	0.4	-0.5	0.3	-0.5	-0.7	-0.9	-0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.9	-0.1	0.1	-0.1	-0.5	-0.6	0.9	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.0	1.0	-0.5	0.2	-0.2	0.1	-0.2	-0.1
Bipolar Disorder (2018)	0.1	0.2	0.4	0.1	0.2	0.5	0.4	0.6	-0.3	0.4
Bipolar Disorder or Schizophrenia	0.1	0.4	1.3	-1.0	-0.1	-0.2	0.0	0.2	-1.1	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.9	0.3	1.0	0.8	0.1	-0.3	0.7	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.2	0.3	-0.2	0.4	0.3	0.5	0.5
Crohns Disease (2017)	0.1	0.3	1.6	0.0	0.7	1.3	0.1	-0.0	-0.0	0.1
Major Depression (MDD)	0.1	0.1	0.4	-0.3	-0.1	-0.2	0.4	0.6	-0.1	0.6
Prostate Cancer	0.1	0.1	0.3	0.3	-0.6	0.4	-0.2	-0.1	-0.2	-0.3
HDL Cholesterol	0.1	0.1	0.2	-0.0	0.1	-0.5	-0.4	-0.5	0.4	-0.0
Blood Red Count	0.1	1.2	4.7	2.2	-0.3	-0.3	-0.2	0.3	-1.5	-1.0
Height	0.1	2.4	4.8	1.6	1.9	0.8	1.3	1.1	1.5	2.2
Respiratory disease	0.1	0.2	1.1	-1.0	-0.1	-0.0	-0.1	-0.1	-0.2	-0.3
Chronotype (morning person)	0.1	0.3	0.7	-0.5	-0.4	-0.8	-0.2	-0.0	-0.9	-0.5
Hair Pigment	0.1	2.1	3.9	1.1	2.0	1.2	1.5	1.5	1.5	1.1
Tanning	0.1	0.8	1.6	0.7	0.6	1.2	0.8	0.7	1.2	0.8
Hand grip strength (left)	0.1	0.4	1.1	-0.9	0.3	-0.2	0.4	0.4	1.0	0.6
Relative age of first facial hair	0.1	0.2	0.5	-0.7	0.6	-0.6	-0.1	-0.1	0.3	0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.7	-0.4	-0.4	-0.8	-0.0	0.1	-0.3	-0.1
Supplements: Zinc	0.1	0.1	0.4	-0.3	-0.1	-0.2	-0.3	-0.3	-0.6	-0.0
Diabetes (father)	0.1	0.1	0.4	-0.2	-0.5	0.3	0.1	-0.1	0.4	0.6
Severe depression (siblings)	0.1	0.1	0.5	-0.7	-0.1	-0.3	-0.2	-0.2	-0.2	0.2
Hand grip strength (right)	0.1	0.2	1.0	-0.2	0.3	0.1	0.4	0.4	1.0	0.4
Taking other prescription medications	0.1	0.1	0.3	0.3	-0.5	0.2	0.2	0.6	0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	0.2	0.6	0.2	0.3	0.2	0.4	0.4
Number of incorrect matches in round	0.1	0.1	0.3	-0.6	0.1	-0.4	0.0	0.1	0.3	-0.4
Forced vital capacity (FVC)	0.1	0.4	1.1	0.1	0.9	0.6	0.2	0.1	0.9	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.1	0.7	-0.1	0.5	0.4	0.6	0.4
Financial difficulties in last 2 years	0.1	0.2	0.5	0.1	-0.3	0.2	-0.3	-0.4	-0.6	-0.7
Heart attack	0.1	0.2	0.5	0.7	-0.6	-0.0	-0.4	-0.1	-0.4	-0.1
Medication: Simvastatin	0.1	0.2	0.4	0.2	-0.2	0.6	-0.3	-0.4	0.6	-0.1
Number of live births	0.1	0.1	0.4	-0.1	-0.4	0.6	-0.2	0.0	0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.9	-0.2	0.6	0.3	0.2	0.1	0.5	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	-0.3	0.4	-0.4	-0.0	-0.2	0.3	0.8
Impedance of arm (left)	0.1	0.4	2.0	-1.4	0.4	-0.4	-0.3	-0.6	-0.5	0.0
Glaucoma (self-reported)	0.1	0.2	0.6	-0.1	-0.2	0.8	0.0	0.3	-0.1	-0.6
Gout (self-reported)	0.1	0.2	0.5	0.7	-0.1	0.6	-0.1	-0.3	0.5	0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.6	0.1	0.4	0.1	0.2	0.1	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	1.4	-0.2	1.0	-0.1	0.3	0.1	0.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	-0.1	0.2	-0.5	-0.6	-0.4	0.0
Health satisfaction	0.1	0.2	0.3	-0.5	-0.6	0.3	-0.3	-0.2	-0.5	-0.4
Medication: Allopurinol	0.1	0.2	0.4	0.4	-0.6	0.1	-0.5	-0.5	0.1	-0.3
Comparative height size at age 10	0.1	0.3	1.1	0.3	0.5	0.9	0.4	0.3	0.2	1.0
Number of full sisters	0.1	0.1	0.4	0.1	0.1	0.6	0.3	0.5	-0.1	-0.0
Age at last live birth	0.1	0.1	0.3	0.0	0.5	0.3	0.4	0.5	-0.2	0.4
Family relationship satisfaction	0.1	0.2	0.4	0.4	-0.5	-0.3	-0.2	-0.1	-0.4	-0.7
Knee pain experienced in last month	0.1	0.2	0.4	0.0	0.1	0.6	0.6	0.5	0.3	0.6
Illnesses of father: Heart disease	0.1	0.2	0.6	0.2	-0.5	0.8	-0.2	-0.2	0.6	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.3	-0.5	0.4	0.4	0.0	-0.1	-0.3	0.1
Loneliness, isolation	0.1	0.1	0.4	0.3	-0.0	0.5	-0.1	-0.5	-0.1	-0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.3	-0.2	0.3	0.5	0.6	-0.5	0.2
Diabetes diagnosed by doctor	0.1	0.2	1.1	1.1	-0.6	-0.4	-0.2	0.1	-0.1	-0.1
Medication for cholesterol	0.1	0.1	0.3	-0.4	0.1	-0.4	-0.2	-0.4	-0.5	0.0
Asthma (self-reported)	0.1	0.2	0.3	-0.4	0.4	0.3	0.5	0.5	0.2	0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.6	-0.7	0.2	-0.1	-0.1	-0.5	-0.2
High cholesterol (Self-reported)	0.1	0.2	1.1	0.3	0.0	1.1	0.5	0.4	0.4	0.2
Ever depressed for a whole week	0.1	0.1	0.5	0.0	0.5	-0.1	0.0	-0.2	0.3	0.7
Impedance of whole body	0.1	0.5	2.2	-1.5	0.4	-0.7	-0.4	-0.5	-0.3	-0.0
Blood Eosinophil Count	0.0	0.3	0.8	-0.8	-0.5	0.4	-0.2	-0.2	-0.4	-0.9
Lung FVC	0.0	0.2	0.4	0.6	0.4	0.4	-0.1	-0.3	0.6	0.7
Medication for hormone replacement therapy	0.0	0.1	0.1	0.3	-0.2	0.3	-0.0	-0.0	-0.3	-0.1
Medication: Co-codamol	0.0	0.0	0.2	0.1	0.0	0.3	0.1	-0.1	0.5	0.0
Medication: Ramipril	0.0	0.0	0.2	0.2	-0.1	0.2	0.1	0.0	0.4	0.2
Asthma	0.0	0.1	0.1	-0.2	0.3	0.3	0.3	0.4	0.2	0.1
Medication: Cholesterol lowering	0.0	0.0	0.1	0.2	0.0	0.1	-0.1	0.0	0.1	-0.3
Standing height	0.0	0.3	0.6	0.0	0.8	0.6	-0.1	-0.4	0.5	0.8
Comparative body size at age 10	0.0	0.1	0.2	0.3	0.1	-0.4	-0.2	-0.3	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.4	-0.1	0.4	-0.2	0.1	-0.0	-0.3	0.7

Hub : Genes

ANKRD28

Models

Trait associations