Hub : Genes

ANTXR1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.2820	0.0820	3.2e-03	-0.003	NA	0.000	NA	-0.005	0.46	NA	3.4e-01	NA	0.5900
2	ROSMAP	Brain Pre-frontal Cortex	0.1264	0.0347	1.6e-06	0.003	0.044	0.038	0.044	0.017	0.14	2.2e-06	9.7e-06	2.2e-06	0.0023
3	TCGA	Prostate Adenocarcinoma	0.0465	0.0222	7.2e-03	-0.001	0.014	0.003	NA	0.001	0.39	1.1e-02	1.3e-01	NA	0.2200

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.9	1.4	3.2	1.8	0.8	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	0.8	0.2	0.3
Depressed Affect (Nagel 2018)	0.3	0.5	1.6	1.3	-0.2	-0.2
Depression (Nagel 2018)	0.3	0.4	0.8	0.9	-0.7	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.1	0.4	-1.0	-0.7
Neuroticism (Nagel 2018)	0.5	1.2	2.7	1.6	-1.0	-0.2
Schizophrenia (2018)	0.2	0.3	0.7	-0.3	-0.4	0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	0.2	-1.0	0.6
Worry (Nagel 2018)	0.8	1.7	3.3	0.3	-1.3	1.8
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	0.5	-0.1	0.7
Alzheimer’s Disease (in father)	1.8	2.0	5.2	2.3	0.5	0.7
Alzheimer’s Disease (including proxy)	0.7	1.1	2.6	1.6	0.3	0.7
Crohns Disease (2017)	0.4	0.9	1.2	1.1	1.1	-0.6
Irritable Bowel Disease (IBD)	0.5	1.3	2.6	1.6	1.1	0.0
Ulcerative Colitis (UC)	0.5	1.0	2.1	1.4	0.3	0.8
Major Depression (MDD)	1.1	1.4	3.6	1.9	-0.6	0.4
Reaction Time	0.8	1.5	3.8	0.1	1.9	-0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.9	1.1	-1.7	0.2
Breast Cancer	6.5	15.6	38.1	1.7	2.4	-6.2
Ovarian Cancer	0.1	0.2	0.2	-0.4	-0.5	0.5
Prostate Cancer	2.0	2.8	5.2	1.5	2.3	0.9
Age at First Birth	2.8	4.1	11.9	-0.0	-3.5	0.7
Bipolar Disorder (2011)	0.4	0.4	0.8	-0.6	-0.9	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	-0.3	-0.7	-0.7
Coronary Artery Disease (CAD)	0.6	0.7	1.6	0.7	-1.3	0.2
Crohns Disease (2012)	0.9	1.4	3.7	0.7	-0.2	-1.9
Mean Putamen Volume	0.4	0.5	0.8	0.6	0.5	-0.9
Fasting Glucose	0.4	0.5	1.3	-1.1	0.2	-0.1
HbA1C	0.2	0.3	0.4	-0.4	0.6	0.5
HDL Cholesterol	0.2	0.4	1.0	1.0	0.1	-0.2
LDL Cholesterol	0.9	1.4	4.0	-0.4	-2.0	0.1
Lupus	0.5	0.7	1.1	-0.8	0.7	-1.0
Neuroticism (2016)	0.7	0.9	1.9	0.0	-1.4	0.9
Primary Biliary Cirrhosis	1.3	1.8	4.6	-2.1	-0.9	-0.2
Rheumatoid Arthritis	0.3	0.4	1.0	-0.3	0.4	1.0
Schizophrenia (2014)	0.0	0.0	0.1	0.3	0.2	-0.0
Triglycerides	0.9	1.6	3.2	-1.1	-1.8	0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	-0.1	-1.2	0.4
Ulcerative Colitis	1.4	2.0	4.5	2.1	1.3	-0.0
Blood Eosinophil Count	0.2	1.8	4.8	-0.6	-2.2	0.5
Blood Platelet Count	0.1	1.2	1.8	-1.2	0.5	1.4
Blood Red Count	0.3	2.6	6.5	-0.9	2.5	-0.7
Blood White Count	0.2	1.8	4.8	-0.8	-0.3	2.2
Heel T-Score	0.6	4.4	8.9	-1.9	-3.0	-0.9
BMI	0.1	0.6	0.9	1.0	0.5	-0.8
Height	0.5	9.6	27.1	1.1	-5.2	-0.6
Waist Hip Ratio (WHR)	0.1	0.4	1.0	0.4	-0.1	-1.0
Systolic Blood Pressure	0.7	3.3	5.7	-1.7	-2.4	1.1
Smoking Status	0.1	0.2	0.4	-0.2	-0.3	-0.6
Allergy or Eczema	0.2	0.5	1.3	0.1	-1.1	0.5
Cardiovascular Disease	1.0	3.3	6.8	-1.4	-2.6	1.1
Hypothyroidism (self reported)	1.3	2.9	8.0	2.8	-0.8	0.3
Respiratory disease	0.5	1.1	2.0	0.5	-1.4	1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	-0.7	-0.2	0.8
Lung FEV1/FVC ratio	1.6	8.1	12.6	-0.7	-3.4	3.5
Lung FVC	3.7	18.7	25.0	-5.0	3.7	-4.2
Neuroticism	0.4	1.0	2.7	1.6	-0.6	-0.4
Chronotype (morning person)	0.4	1.0	2.8	-0.6	1.7	0.1
Hair Pigment	0.3	7.3	14.2	1.0	-3.8	2.6
Tanning	0.1	0.9	1.7	0.4	1.3	-1.0
Hand grip strength (left)	1.2	3.1	5.8	0.5	1.8	-2.4
Number of treatments/medications taken	1.6	2.8	7.4	-0.8	-2.7	0.7
Average weekly spirits intake	1.7	2.1	4.3	-0.3	-1.4	2.1
Sensitivity / hurt feelings	0.4	0.8	2.0	0.4	-1.4	-0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.6	1.2	-1.3	0.3
Hearing difficulty/problems: Yes	0.5	0.8	1.3	-0.6	-1.1	-0.8
Relative age of first facial hair	0.4	0.9	1.4	-1.2	1.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.3	0.1	0.1	-1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.6	-0.2	-1.3	-0.1
Ever had hysterectomy (womb removed)	1.5	1.7	2.3	-1.4	1.5	-0.9
Systolic blood pressure, automated reading	0.1	0.2	0.6	-0.8	-0.3	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.6	-0.5	0.4	-0.8
Angina	1.0	1.4	1.5	-1.2	1.2	-1.1
Medication for hormone replacement therapy	0.5	0.5	1.6	0.2	-0.0	1.3
Vitamin and mineral supplements	1.2	1.6	2.6	-1.3	1.6	0.6
Supplements: Zinc	0.5	0.6	1.6	0.2	-0.1	-1.3
Medication: Co-codamol	0.6	0.7	1.3	-0.7	-0.5	1.2
Medication: Metformin	0.4	0.5	0.6	-0.7	-0.6	0.8
Diabetes (father)	1.2	1.5	2.2	0.7	-1.5	1.3
Diabetes (mother)	0.1	0.2	0.3	0.5	-0.3	0.3
Severe depression (siblings)	1.3	1.4	3.6	1.9	-0.7	0.5
Pack years adult smoking proportion	1.0	1.6	4.6	2.1	0.1	0.3
Impedance of leg (right)	0.9	4.1	11.0	-0.6	-1.0	3.3
Leg fat-free mass (left)	0.5	2.6	3.7	1.7	-1.1	-1.9
Trunk fat percentage	0.6	2.5	6.2	1.0	-0.7	2.5
Hand grip strength (right)	1.5	4.0	7.8	0.2	2.0	-2.8
Townsend deprivation index at recruitment	0.3	0.4	0.5	0.5	0.6	-0.7
Current tobacco smoking	0.2	0.4	0.9	0.1	-1.0	-0.3
Average weekly fortified wine intake	0.5	0.6	1.5	-1.2	-0.0	0.4
Maternal smoking around birth	1.4	2.0	5.3	-0.5	-2.3	-0.6
Fed-up feelings	0.3	0.5	1.4	1.2	-0.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	2.3	1.5	-1.3	0.7
Relative age voice broke	0.4	0.6	1.0	-1.0	-0.9	-0.2
Taking other prescription medications	1.3	2.1	3.8	-1.3	-1.9	0.8
Age when periods started (menarche)	0.3	0.7	1.6	0.7	-1.3	-0.3
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	5.0	-2.2	-0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.2	-0.4	-1.5	-1.3
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	4.1	1.9	2.0	0.8
Qualifications: CSEs or equivalent	0.3	0.4	0.7	-0.1	0.6	-0.8
Serious illness, injury or assault to yourself	0.0	0.1	0.1	0.4	0.0	0.1
High blood pressure	0.6	1.7	2.5	-0.8	-1.4	1.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	0.4	-0.4	0.8
Multivitamins +/- minerals	1.7	2.2	4.5	1.3	-2.1	0.5
Stomach or abdominal pain in last month	2.0	2.5	7.0	-0.2	2.6	0.8
Supplements: Glucosamine	1.3	1.7	2.2	1.1	-1.5	1.3
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	3.1	1.5	1.8	-1.6
Medication: Atenolol	0.2	0.2	0.3	0.4	-0.4	0.5
Medication: Levothyroxine sodium	1.0	1.7	5.1	0.3	-2.2	-0.2
Sitting height	1.2	8.2	23.9	0.6	-4.9	0.5
Chronic bronchitis/emphysema (father)	0.9	1.0	1.6	-1.1	1.3	-0.5
High blood pressure (mother)	0.6	0.9	1.7	-0.2	-1.3	1.0
Body mass index (BMI)	0.3	1.2	2.3	1.0	1.5	-0.3
Impedance of leg (left)	0.8	4.1	11.4	-0.3	-0.9	3.4
Leg predicted mass (left)	0.5	2.6	3.8	1.7	-1.1	-2.0
Trunk fat mass	0.3	1.3	1.8	1.3	-0.6	1.4
Waist circumference	0.1	0.4	1.1	1.1	0.0	0.2
Number of incorrect matches in round	0.6	1.0	1.8	0.3	1.0	1.4
Past tobacco smoking	0.3	0.5	1.3	-0.0	-1.1	-0.4
Alcohol usually taken with meals	0.4	0.6	1.0	1.0	0.8	0.1
Nervous feelings	0.7	1.4	2.6	-1.2	-0.2	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	4.0	1.7	-2.0	1.2
Hearing difficulty/problems with background noise	0.6	0.9	2.0	0.7	0.5	-1.4
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	0.4	0.9	-0.2
Had menopause	1.6	2.0	4.5	1.2	0.1	-2.1
Had other major operations	1.4	1.7	4.4	2.1	0.8	0.5
Forced vital capacity (FVC)	0.9	3.4	7.6	-1.5	0.5	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.6	-0.5	-1.6	-1.9
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.1	0.7	1.8	-0.8
Qualifications: None of the above	0.9	2.0	2.9	-1.6	1.7	0.6
Financial difficulties in last 2 years	1.0	1.4	4.1	2.0	0.3	0.1
Mouth/teeth dental problems	0.2	0.4	0.8	0.9	0.5	0.2
Heart attack	0.2	0.2	0.4	0.6	0.6	-0.1
Allergy	0.3	0.7	0.8	-0.9	0.8	-0.7
Pain all over the body in last month	1.1	1.2	1.8	1.1	1.4	0.7
Diabetes (self-reported)	0.1	0.1	0.3	-0.2	0.5	0.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	3.2	-1.4	-1.8	0.3
Medication: Ramipril	1.1	1.4	2.1	-1.5	-1.0	1.0
Medication: Simvastatin	1.2	1.8	3.0	-1.5	0.5	-1.7
Fluid intelligence score	0.6	1.2	3.5	0.4	-1.9	-0.1
Illnesses of siblings	1.0	1.4	4.1	0.1	-0.4	-2.0
Neuroticism score	0.4	0.9	1.3	1.0	-1.1	-0.6
Weight	0.2	1.0	2.3	1.5	-0.5	-0.5
Impedance of arm (right)	1.6	7.4	11.6	-1.6	-3.4	2.8
Arm fat percentage (right)	0.2	0.7	2.0	0.2	0.2	1.4
Trunk fat-free mass	0.6	3.5	7.1	1.8	-0.4	-2.7
Hip circumference	0.2	0.8	1.2	1.1	-0.9	0.6
Time employed in main current job	0.8	0.9	2.3	0.6	-0.4	1.5
Alcohol intake versus 10 years previously	0.7	1.1	2.7	1.6	0.1	0.7
Father’s age at death	0.2	0.3	0.4	0.5	0.5	0.6
Worrier / anxious feelings	0.4	0.8	2.0	0.6	-1.4	0.2
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	9.2	3.0	0.3	1.1
Falls in the last year	1.8	2.4	5.0	1.4	0.7	2.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.2	-1.1	0.8	0.4
Number of live births	3.6	5.1	9.8	-1.3	1.9	-3.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.2	-1.8	-0.1	-1.7
Pulse rate	0.3	0.6	1.2	0.6	-0.4	1.1
Happiness	0.5	0.6	1.0	1.0	0.8	0.4
Noisy workplace	0.7	0.9	1.7	-1.0	1.3	-0.2
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.7	1.1	-2.2	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.4	0.1	0.6
Mouth/teeth dental problems: Dentures	0.8	1.4	3.9	-2.0	0.4	0.1
Asthma	1.5	2.9	5.3	1.6	-0.9	2.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	3.4	1.3	1.3	1.8
Medication: Cholesterol lowering	0.7	1.1	1.8	-1.3	0.0	-1.2
Depression (self-reported)	1.0	1.2	2.1	1.0	-1.4	0.7
Medication: Lansoprazole	0.6	0.7	1.7	-1.3	0.4	0.6
Prospective memory result	1.6	2.0	5.2	-2.3	-0.8	-0.3
Lung cancer (father)	0.1	0.2	0.4	-0.2	0.6	-0.2
Illnesses of mother	3.4	4.1	6.4	1.5	2.5	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.3	-1.3	-0.1	-1.8
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	0.0	-1.2	0.8
Impedance of arm (left)	1.5	6.8	10.2	-1.5	-3.2	2.8
Arm fat mass (right)	0.1	0.4	0.9	0.9	0.2	0.5
Trunk predicted mass	0.6	3.4	7.0	1.7	-0.4	-2.6
Standing height	0.8	7.5	20.9	1.2	-4.6	-0.5
Length of working week for main job	1.7	1.9	4.8	0.9	0.2	2.2
Exposure to tobacco smoke at home	1.7	1.9	4.4	-1.1	2.1	-0.3
Breastfed as a baby	0.7	0.8	2.1	-0.5	-1.4	-0.4
Tense / ‘highly strung’	0.5	0.8	1.3	1.2	-1.0	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.4	1.2	0.6	-0.6
Hair/balding pattern: Pattern 4	0.3	0.8	1.7	-0.8	-1.3	0.5
Birth weight of first child	0.4	0.8	1.7	1.3	0.7	-0.4
Peak expiratory flow (PEF)	0.3	0.8	1.0	-0.9	-1.0	0.6
Pulse wave reflection index	1.4	1.7	3.1	-1.2	-1.8	-0.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.7	-1.3	0.1	-0.2
Loud music exposure frequency	0.2	0.2	0.3	-0.4	0.6	-0.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	4.8	2.2	-0.9	1.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	1.7	1.3	-1.1	1.3
Blood clot in the leg (DVT)	1.0	1.3	2.6	1.1	1.6	-0.5
Medication: Paracetamol	0.4	0.7	1.2	0.5	0.8	1.1
Headache pain in last month	1.2	2.0	4.6	2.1	0.5	-1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.6	0.7	-0.2
Glaucoma (self-reported)	1.6	1.9	3.5	-1.9	-1.5	-0.1
Gout (self-reported)	0.2	0.2	0.5	0.3	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	5.7	1.7	-2.4	0.4
Medication: Amlodipine	0.8	1.1	2.6	-0.6	-1.6	0.6
Medication: Ventolin 100micrograms inhaler	3.5	4.5	7.0	0.2	-2.6	2.7
Birth weight	1.2	2.6	7.0	0.2	-2.6	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.1	-1.1	-0.4	-0.2
High blood pressure (siblings)	1.0	1.4	2.3	-1.1	0.7	1.5
Forced vital capacity (FVC), Best measure	0.8	2.9	7.5	-0.8	0.7	-2.7
Body fat percentage	0.5	1.9	4.8	1.0	0.2	2.2
Leg fat percentage (right)	0.4	1.4	2.7	0.7	1.6	1.1
Arm fat-free mass (right)	0.6	3.1	5.9	2.4	-0.1	-1.9
Exposure to tobacco smoke outside home	1.6	2.1	4.8	0.6	2.2	1.0
Comparative body size at age 10	0.2	0.5	0.7	-0.6	0.6	0.8
Number of full brothers	0.3	0.3	0.8	-0.3	0.3	0.9
Worry too long after embarrassment	0.9	1.4	3.1	1.8	-0.5	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	-0.6	-1.2	0.7
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	-0.3	-1.1	-0.0
Number of children fathered	0.2	0.3	0.4	0.6	-0.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.7	0.8	0.8	-0.4
Age at first live birth	1.2	2.1	5.5	0.1	-2.3	-0.8
Pulse wave peak to peak time	0.3	0.4	0.7	0.3	0.6	-0.8
Health satisfaction	1.8	2.4	3.7	1.9	0.0	1.9
Shortness of breath walking on level ground	0.4	0.5	0.8	0.9	0.7	0.6
Qualifications: College or University degree	0.2	0.7	1.7	0.6	-1.3	-0.3
Eye problems/disorders: None of the above	0.0	0.0	0.1	0.0	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	1.0	1.1	3.4	0.1	1.8	0.1
Emphysema/chronic bronchitis	0.3	0.3	0.5	0.1	-0.7	0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	1.6	-0.6	-1.3	0.8
Neck or shoulder pain in last month	0.2	0.3	0.9	0.3	0.1	-0.9
Medication: Blood pressure	0.4	0.8	1.6	0.4	-0.7	1.3
Angina (self-reported)	1.3	1.7	2.4	-1.3	1.5	-1.0
Migraine (self-reported)	0.4	0.5	1.2	1.1	0.3	0.3
Medication: Ibuprofen	0.7	0.9	2.3	0.4	0.4	1.5
Medication: Allopurinol	0.3	0.4	0.8	0.3	-0.9	0.6
Medication: Omeprazole	1.1	1.4	3.8	0.2	0.5	-2.0
Medication: Seretide 50 evohaler	1.0	1.2	1.5	-1.2	-0.7	1.2
Mean time to correctly identify matches	1.3	2.4	5.8	-0.4	2.4	-1.1
Heart disease (mother)	2.1	2.6	5.7	-2.4	-1.4	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	0.8	-1.1	-0.0
Whole body fat mass	0.3	1.3	2.0	1.4	-0.1	1.3
Leg fat mass (right)	0.2	0.7	1.1	1.1	0.9	0.4
Arm predicted mass (right)	0.7	3.6	6.6	2.6	0.3	-2.1
Pulse rate, automated reading	0.7	2.3	6.2	0.6	-0.6	2.5
Alcohol intake frequency.	0.5	1.2	2.6	0.7	1.6	-0.8
Comparative height size at age 10	0.6	3.4	8.4	1.3	-2.9	-0.3
Number of full sisters	0.9	1.0	2.4	-1.5	0.1	-0.8
Suffer from ‘nerves’	2.2	3.4	5.7	0.1	-2.4	2.1
Overall health rating	1.4	2.9	5.2	1.5	1.1	2.3
Chest pain or discomfort	0.1	0.1	0.1	-0.3	-0.3	-0.4
Had major operations	0.2	0.2	0.4	0.3	0.1	-0.7
Age at last live birth	1.5	2.1	3.9	0.5	-1.5	-2.0
Family relationship satisfaction	0.7	0.9	1.1	0.6	-1.1	1.1
Leg pain on walking	0.1	0.1	0.2	0.2	0.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	0.5	-1.1	-0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.7	-0.1	0.3	-1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.9	-0.4	0.9	-0.8
Medication: Aspirin	0.2	0.3	0.6	-0.6	-0.2	-0.8
Supplements: Vitamin C	0.5	0.6	1.2	-0.7	-0.3	-1.1
Knee pain experienced in last month	1.4	2.2	4.5	1.2	0.7	2.1
Hypertension (Self-reported)	0.9	2.4	3.4	-1.2	-1.9	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.3	-0.8	0.4	-1.5
Illnesses of father: Heart disease	0.3	0.4	0.4	-0.6	-0.7	0.6
Illnesses of siblings: Diabetes	0.9	1.1	1.5	1.0	0.8	1.2
Smoking status: Previous	0.7	1.1	2.4	0.2	1.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.8	1.7	0.6	-0.2
Whole body fat-free mass	0.6	3.5	6.1	2.0	-0.6	-2.5
Leg fat-free mass (right)	0.5	2.7	4.0	1.8	-1.1	-2.0
Arm fat percentage (left)	0.2	0.7	1.8	0.4	0.2	1.3
Average weekly red wine intake	0.6	0.9	1.8	0.6	-1.3	0.8
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.7	-0.8	0.3	1.3
Mood swings	0.3	0.5	1.0	0.7	-1.0	0.1
Loneliness, isolation	0.6	0.8	1.1	0.1	-1.1	-1.1
Long-standing illness, disability or infirmity	1.2	1.8	2.7	-0.6	-1.6	1.6
Ever had bowel cancer screening	0.1	0.1	0.3	0.5	-0.0	-0.1
Diabetes diagnosed by doctor	0.1	0.1	0.1	0.4	0.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	-0.0	1.0	-0.5
Friendships satisfaction	0.9	1.1	2.1	-0.2	-1.4	-1.1
Qualifications: nursing, teaching	1.0	1.6	3.3	0.9	-1.8	0.8
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.1	0.6	0.6
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.7	-0.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.9	0.2	1.0	-1.4
Medication for cholesterol	0.7	1.0	2.3	-0.1	1.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	0.3	0.1	1.0
Back pain experienced in last month	0.9	1.3	1.9	1.4	-0.3	1.4
Mineral and other dietary supplements	0.9	1.2	3.4	-0.5	1.8	-0.3
Breast cancer (self-reported)	0.4	0.5	1.0	-0.2	-1.0	0.6
Asthma (self-reported)	1.5	3.1	4.9	1.9	-0.8	2.2
Osteoporosis (self-reported)	1.7	2.1	5.1	-0.8	2.2	-0.9
Osteoarthritis (self-reported)	0.1	0.1	0.4	-0.1	-0.2	0.6
Medication: Aspirin	0.3	0.4	0.5	-0.7	-0.4	-0.7
Medication: Gliclazide	2.2	2.5	4.9	-2.2	-1.1	1.2
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	0.7	-0.4	0.2
Smoking status: Current	0.4	0.6	1.3	-0.1	-1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.4	-1.6	1.2	-0.4
Whole body water mass	0.6	3.3	5.7	2.0	-0.7	-2.4
Leg predicted mass (right)	0.5	2.9	4.2	1.8	-1.1	-2.0
Arm fat mass (left)	0.1	0.5	1.2	1.1	0.3	0.6
Number of self-reported non-cancer illnesses	0.6	1.1	2.7	-0.4	-1.6	-0.6
Average weekly champagne plus white wine intake	1.8	2.4	6.7	0.2	-2.6	0.8
Miserableness	1.1	1.9	3.0	1.7	1.4	-0.9
Guilty feelings	1.5	2.3	4.1	1.5	-0.7	-2.0
Wears glasses or contact lenses	0.1	0.1	0.1	-0.2	0.4	0.4
Ever taken oral contraceptive pill	0.2	0.3	0.5	-0.2	0.5	0.7
Hearing aid user	4.4	5.0	11.3	1.8	-0.6	3.4
Mother’s age at death	2.0	2.5	5.1	2.3	0.9	-1.2
Financial situation satisfaction	1.8	2.2	6.7	2.6	-0.0	0.0
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.1	-0.3	0.7	-1.5
Commuting to job workplace: Public transport	1.4	1.7	2.4	1.1	-1.6	1.2
Eye problems/disorders: Glaucoma	1.6	1.9	3.9	-0.3	-2.0	1.3
Medication: Blood pressure	1.1	2.0	4.8	-0.5	-2.2	1.0
Pain type(s) experienced in last month: Hip pain	2.3	2.9	5.7	1.3	-1.2	2.4
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.6	0.7	-1.3	1.0
High cholesterol (Self-reported)	0.4	0.6	1.5	-0.5	-1.2	-0.5
Medication: Bendroflumethiazide	0.4	0.6	1.0	1.0	-0.3	0.8
Medication: Paracetamol	0.1	0.2	0.3	-0.6	-0.3	0.5
Medication: Lisinopril	1.5	1.9	3.9	-0.0	-1.4	2.0
Medication: Atorvastatin	0.6	0.7	1.7	0.6	-1.3	0.0
Illnesses of father: High blood pressure	0.8	1.0	2.2	0.5	1.5	-0.8
Alcohol drinker status: Never	0.9	1.1	2.4	-1.0	-0.1	-1.6
Ever smoked	0.1	0.2	0.6	0.7	-0.1	0.1
Basal metabolic rate	0.5	2.6	4.0	2.0	-0.6	-1.9
Leg fat percentage (left)	0.5	1.8	2.9	1.0	1.7	1.3
Arm fat-free mass (left)	0.7	3.3	6.8	2.6	0.1	-1.8
Number of operations (self-reported)	0.1	0.1	0.1	0.3	-0.4	-0.4
Average weekly beer plus cider intake	0.4	0.6	1.6	-0.3	0.3	-1.3
Irritability	1.9	3.3	6.4	1.9	-0.0	-2.5
Risk taking	0.5	0.7	1.3	0.9	-0.1	-1.1
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	-0.4	0.2	-0.5
Fractured/broken bones in last 5 years	0.6	0.8	2.2	0.4	0.1	1.5
Age started oral contraceptive pill	0.5	0.6	0.9	0.3	0.9	-0.9
Diastolic blood pressure, automated reading	0.1	0.5	0.7	-0.6	0.9	0.5
Ever depressed for a whole week	0.2	0.2	0.3	-0.1	0.6	-0.5
Unable to work because of sickness or disability	1.1	1.4	2.5	1.0	-0.9	1.6
Commuting to job workplace: Cycle	2.3	2.7	6.4	-0.6	-2.5	-1.2
Myopia	0.5	0.7	1.8	-0.3	1.3	-0.4
Vascular/heart problems diagnosed by doctor	0.7	2.0	2.6	1.0	1.5	-1.6
Cholesterol lowering medication	0.8	1.1	3.2	-0.2	-1.8	0.2
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	5.0	-0.2	1.0	-2.2
Pain experienced in last month	1.1	1.8	3.5	-1.9	0.7	-1.2
Supplements: Calcium	0.9	1.0	1.8	-0.9	0.6	-1.3
Basal cell carcinoma (self-reported)	3.6	4.3	12.0	0.0	-3.5	0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	0.6	0.3	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.2	1.1	1.5	-0.5
Heart disease (siblings)	0.4	0.4	0.9	-0.6	0.3	0.9
Alcohol drinker status: Previous	0.5	0.6	1.0	1.0	0.8	-0.4
Pack years of smoking	1.0	1.5	4.5	2.1	0.2	0.2
Impedance of whole body	1.4	7.0	13.3	-1.0	-2.6	3.6
Leg fat mass (left)	0.2	0.8	1.4	1.2	0.9	0.4
Arm predicted mass (left)	0.6	3.3	7.0	2.6	0.1	-1.7