Hub : Genes

ANTXR2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0550 0.0260 8.3e-03 0.001 0.008 0.031 0.012 0.006 2.0e-01 3.5e-02 9.2e-05 1.0e-02 4.9e-02
2 GTEx Adipose Subcutaneous 0.0920 0.0410 5.5e-03 0.053 NA 0.074 NA 0.064 3.6e-05 NA 1.1e-06 NA 5.7e-06
3 GTEx Cells Transformed fibroblasts 0.1670 0.0590 4.2e-03 0.100 NA 0.088 NA 0.072 6.7e-08 NA 4.2e-07 NA 4.2e-06
4 METSIM Adipose 0.0438 0.0201 3.7e-03 0.010 0.005 -0.001 0.006 0.002 1.0e-02 4.6e-02 5.5e-01 3.5e-02 1.3e-01
5 YFS Blood 0.0331 0.0119 2.8e-05 0.017 0.021 0.015 0.022 0.014 2.6e-06 1.1e-07 5.9e-06 6.9e-08 1.6e-05
6 TCGA Colon Adenocarcinoma 0.0890 0.0510 6.9e-03 0.014 0.003 -0.003 NA 0.020 5.1e-02 1.9e-01 4.9e-01 NA 2.3e-02
7 TCGA Ovarian Serous Cystadenocarcinoma 0.0720 0.0370 3.0e-03 0.077 0.021 0.032 NA 0.069 6.7e-06 1.3e-02 3.2e-03 NA 2.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.8 1.2 3.5 -0.7 0.2 1.9 -1.0 1.3 -1.2 0.6
Bipolar Disorder or Schizophrenia 0.3 0.7 2.2 0.4 -1.1 1.5 -0.6 0.3 -0.8 -0.1
Depressed Affect (Nagel 2018) 0.9 1.8 5.8 2.4 -0.1 -0.5 1.2 2.3 -0.0 -0.0
Depression (Nagel 2018) 0.8 1.2 2.6 1.4 1.1 0.1 1.6 1.0 0.8 -0.8
Intelligence (Savage-Jansen 2018) 1.7 5.1 12.4 -1.9 -2.0 0.4 -1.0 3.5 -2.3 -3.0
Neuroticism (Nagel 2018) 1.0 2.2 7.7 1.2 -0.4 -0.6 1.9 2.8 0.7 -1.4
Schizophrenia (2018) 0.3 0.7 2.5 1.0 -1.6 0.5 -0.0 -0.6 -0.1 -0.6
Schizophrenia vs Biploar Disorder 1.0 1.4 3.7 1.4 -1.2 -1.9 -1.2 -0.7 -0.6 -0.5
Worry (Nagel 2018) 1.0 2.2 7.0 -0.1 -0.3 -1.0 0.7 2.4 1.0 -2.6
Alzheimer’s Disease (in mother) 1.1 1.3 5.2 -1.7 -0.4 -0.2 -2.3 -0.7 -0.7 -0.1
Alzheimer’s Disease (in father) 2.7 2.9 8.9 -1.0 -1.6 -3.0 -1.3 0.1 -1.8 -1.8
Alzheimer’s Disease (including proxy) 2.3 3.4 8.4 -1.8 -0.9 -2.5 -2.9 -0.7 -1.9 -1.0
Crohns Disease (2017) 1.3 2.8 8.2 1.3 1.5 2.9 0.9 -0.1 -1.2 2.4
Irritable Bowel Disease (IBD) 0.5 1.2 3.4 1.0 0.2 1.7 1.0 0.1 0.1 1.9
Ulcerative Colitis (UC) 0.4 0.8 2.0 0.8 -0.9 -0.1 0.9 0.4 1.4 1.1
Major Depression (MDD) 1.3 1.6 4.8 1.6 0.8 0.9 2.2 1.3 -0.0 0.7
Reaction Time 0.2 0.4 1.0 0.6 -0.2 0.4 -0.4 -0.2 1.0 1.0
Verbal and Numeric Reasoning (VNR) 2.3 5.4 12.7 -3.6 -2.4 0.0 0.4 2.5 -0.9 -3.5
Breast Cancer 1.0 2.4 6.3 -0.7 0.5 -1.5 2.0 2.5 1.2 -1.5
Ovarian Cancer 0.1 0.1 0.4 0.4 0.1 0.0 0.6 -0.6 -0.2 0.0
Prostate Cancer 1.2 1.7 3.5 1.4 1.9 1.1 1.3 -0.7 0.1 1.7
Age at First Birth 1.0 1.4 3.9 -1.3 -0.9 0.0 0.6 2.0 -0.3 -1.7
Bipolar Disorder (2011) 0.6 0.6 1.3 1.0 0.5 -0.1 0.5 0.6 1.0 1.1
Body Mass Index (BMI) (2010) 0.4 0.6 2.2 0.6 0.7 1.5 1.0 -0.2 0.2 -0.2
Coronary Artery Disease (CAD) 0.2 0.3 0.8 0.2 0.9 0.5 -0.6 0.5 0.2 0.6
Crohns Disease (2012) 0.6 1.0 2.9 1.1 0.6 1.0 -1.0 -0.3 -0.7 1.7
Mean Putamen Volume 0.2 0.2 0.5 0.1 0.5 0.2 0.6 -0.1 0.7 -0.4
Fasting Glucose 0.6 0.7 1.4 -0.9 -1.0 1.0 -0.2 0.4 -0.9 -1.2
HbA1C 1.4 1.5 6.5 2.5 0.3 -1.1 -1.3 -0.2 1.0 0.4
HDL Cholesterol 0.2 0.3 1.3 -0.1 0.4 -0.4 0.5 -0.1 -0.4 1.1
LDL Cholesterol 0.3 0.4 1.6 0.2 -0.6 -0.1 -1.2 -0.2 0.1 -1.0
Lupus 1.2 1.8 3.1 1.4 1.0 1.5 -0.6 -1.1 -1.8 1.7
Neuroticism (2016) 0.2 0.3 1.6 0.1 0.6 -0.3 -0.5 0.1 -1.3 0.1
Primary Biliary Cirrhosis 1.7 2.4 4.8 2.2 -0.9 -0.6 -1.5 -1.7 -2.0 1.4
Rheumatoid Arthritis 3.0 4.2 14.6 2.8 0.5 1.2 0.2 -1.8 1.4 3.8
Schizophrenia (2014) 0.2 0.4 1.0 0.8 -0.7 1.0 -0.5 -0.3 -0.2 -0.4
Triglycerides 0.3 0.5 1.1 -0.9 0.5 0.6 0.5 1.0 -0.2 -0.7
Type 2 Diabetes (T2D) (2012) 1.2 1.4 4.7 -2.2 0.2 1.4 -0.2 0.9 -1.1 -1.1
Ulcerative Colitis 0.5 0.8 3.1 1.1 -0.8 0.2 0.4 0.0 0.5 1.8
Blood Eosinophil Count 0.9 7.0 13.5 1.9 3.4 -0.1 2.2 -2.3 3.1 3.7
Blood Platelet Count 0.0 0.4 1.5 -1.2 0.0 0.5 0.6 0.8 -0.1 -0.2
Blood Red Count 0.1 0.8 2.8 -1.3 0.2 -0.9 -0.4 0.1 -1.7 -0.2
Blood White Count 1.9 14.2 32.9 3.4 4.2 1.9 2.7 -3.5 3.7 5.7
Heel T-Score 0.1 0.9 2.7 -0.0 -1.6 -1.3 -1.0 0.6 -0.8 -0.4
BMI 1.9 11.0 22.7 2.3 4.1 1.4 1.8 -3.5 3.9 4.8
Height 0.5 9.1 22.4 -3.8 -0.9 0.2 3.6 3.6 0.5 -4.7
Waist Hip Ratio (WHR) 0.2 1.0 3.4 0.6 -1.8 -0.2 -0.5 -1.4 -0.9 0.5
Systolic Blood Pressure 0.7 3.5 6.8 -2.6 -0.7 -2.6 -0.7 2.0 -1.6 -1.9
Smoking Status 0.3 0.6 1.5 -0.2 0.3 -0.9 1.2 -0.7 -1.0 -0.6
Allergy or Eczema 0.3 0.8 1.9 0.0 0.2 1.2 1.2 0.2 1.4 -0.9
Cardiovascular Disease 0.5 1.5 4.3 0.1 2.1 -2.1 1.1 0.3 0.1 0.8
Hypothyroidism (self reported) 3.2 7.3 19.6 3.4 2.1 2.2 0.7 -3.1 0.4 4.4
Respiratory disease 0.5 1.0 3.6 0.8 -0.2 1.4 0.9 -0.3 1.9 0.5
Type 2 Diabetes (T2D) (2018) 1.1 2.0 4.2 1.8 1.8 0.2 -0.1 -1.8 -0.5 2.0
Lung FEV1/FVC ratio 0.2 0.8 2.3 -1.1 -0.6 -1.5 -0.7 0.0 0.6 -0.7
Lung FVC 0.3 1.6 2.8 1.1 1.4 0.8 1.6 1.1 1.7 -1.0
Neuroticism 0.7 1.8 5.5 1.2 -1.4 0.1 1.4 2.3 0.1 -1.1
Chronotype (morning person) 0.6 1.3 3.1 -0.6 -0.2 1.2 -1.1 -1.5 -1.8 0.9
Hair Pigment 0.0 1.0 2.2 1.4 0.1 0.8 0.9 -1.5 1.1 0.5
Tanning 0.2 2.7 7.1 -2.5 -0.9 -0.5 0.1 1.6 1.2 -2.7
Hand grip strength (left) 1.2 3.2 6.9 -1.6 -2.6 -2.4 -0.9 -0.4 -0.9 -2.4
Number of treatments/medications taken 0.6 1.0 3.0 1.4 -0.0 0.7 -0.6 -1.1 -0.6 1.7
Average weekly spirits intake 3.2 4.0 12.1 1.4 1.4 1.0 2.2 -1.0 3.5 2.1
Sensitivity / hurt feelings 1.1 2.0 6.5 -1.3 -1.0 -0.2 1.5 1.2 2.5 -1.0
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.2 0.4 -0.4 0.4 1.1 0.9 -0.3 -0.4
Hearing difficulty/problems: Yes 1.0 1.5 4.0 1.4 1.0 1.1 0.5 -0.6 2.0 1.4
Relative age of first facial hair 1.1 2.3 5.6 -0.1 1.5 2.4 1.6 1.5 1.2 1.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.1 -1.5 0.3 0.2 -0.3 -1.0 -0.9 -0.2
Ever used hormone-replacement therapy (HRT) 0.9 1.2 3.4 -1.5 -0.2 0.8 -0.3 -0.6 1.2 -1.8
Ever had hysterectomy (womb removed) 0.2 0.3 1.3 -0.2 0.7 0.1 -1.1 -0.2 -0.3 0.1
Systolic blood pressure, automated reading 0.2 0.7 4.1 -0.2 -0.3 -2.0 -0.7 0.1 0.1 -0.0
Eye problems/disorders: Diabetes related eye disease 0.9 0.9 2.8 0.5 0.5 -0.0 1.5 0.8 0.7 1.7
Angina 0.7 0.9 2.6 -1.2 0.3 -0.0 -1.0 -1.6 -1.2 -0.1
Medication for hormone replacement therapy 0.6 0.7 3.6 -0.2 0.7 0.1 0.1 0.4 1.9 0.5
Vitamin and mineral supplements 0.9 1.3 5.1 0.9 0.4 -0.3 -2.2 -0.6 -0.2 1.5
Supplements: Zinc 1.1 1.2 3.5 -0.5 1.3 1.9 0.1 -1.1 1.0 0.7
Medication: Co-codamol 0.2 0.2 1.3 0.0 -1.1 -0.1 -0.0 0.3 0.1 -0.1
Medication: Metformin 1.9 2.7 6.4 1.9 1.9 0.3 -0.2 -2.2 0.6 2.5
Diabetes (father) 1.0 1.3 5.4 -0.6 1.4 2.3 0.6 -0.7 -0.3 0.4
Diabetes (mother) 0.8 1.0 4.4 0.8 -1.1 0.3 -0.1 -0.9 -2.1 0.2
Severe depression (siblings) 0.4 0.5 1.5 0.7 0.5 0.1 0.2 -0.5 -1.2 -0.8
Pack years adult smoking proportion 0.3 0.5 1.7 -0.8 1.3 -0.4 0.2 -0.4 0.4 -0.7
Impedance of leg (right) 0.7 3.3 6.2 -1.5 -2.5 -0.1 2.5 2.1 -1.4 -1.5
Leg fat-free mass (left) 0.4 2.1 6.9 0.5 2.0 -0.5 0.6 -1.4 2.6 1.1
Trunk fat percentage 2.5 9.9 19.8 2.4 3.0 -0.0 3.3 -2.2 4.4 4.5
Hand grip strength (right) 1.4 3.8 9.7 -1.6 -3.1 -2.4 -1.1 -0.2 -0.4 -2.6
Townsend deprivation index at recruitment 0.9 1.3 4.6 0.9 0.2 0.4 -0.8 -2.1 -0.8 1.4
Current tobacco smoking 0.4 0.6 2.8 0.2 -0.1 -0.1 -0.2 -1.7 -1.1 0.0
Average weekly fortified wine intake 0.1 0.1 0.7 -0.1 -0.0 0.0 0.2 0.1 0.8 0.4
Maternal smoking around birth 2.4 3.5 12.6 0.7 3.6 0.2 2.5 0.3 1.9 1.1
Fed-up feelings 0.8 1.4 5.8 2.4 0.9 -0.5 0.3 1.1 -0.6 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.9 8.5 0.7 2.1 -0.1 2.9 1.1 2.3 -0.3
Relative age voice broke 0.1 0.2 1.2 -0.1 -0.5 1.1 -0.1 0.1 -0.1 0.2
Taking other prescription medications 1.9 2.9 6.3 1.9 2.1 1.2 -0.3 -2.1 0.2 2.5
Age when periods started (menarche) 0.2 0.6 2.0 -0.8 0.7 -0.3 1.4 -0.5 0.6 0.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 1.2 -1.0 0.6 0.3 -0.9 -1.0 -1.1 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 2.2 0.5 -1.5 -0.2 -0.3 0.5 -0.9 -0.1
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.1 1.1 0.7 -1.2 1.4 -0.8 1.5 -0.6
Qualifications: CSEs or equivalent 1.2 1.6 5.0 -0.2 1.2 0.1 -0.8 -2.0 -0.1 2.2
Serious illness, injury or assault to yourself 0.6 0.7 1.2 -1.1 0.6 1.1 0.6 -1.0 -0.7 0.6
High blood pressure 0.3 0.9 3.1 0.1 0.8 -1.8 -0.0 0.4 -1.0 1.1
Hayfever, allergic rhinitis or eczema 0.6 1.3 5.0 -0.1 0.9 2.2 0.7 -0.6 1.5 0.1
Multivitamins +/- minerals 1.4 1.7 6.7 -1.2 0.3 -0.3 2.6 0.7 1.1 -1.5
Stomach or abdominal pain in last month 2.5 3.2 8.6 2.1 2.5 1.0 1.2 -0.4 2.9 0.5
Supplements: Glucosamine 0.4 0.5 2.8 -0.1 -1.7 0.5 0.1 -0.6 0.0 -0.5
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 4.2 -0.7 1.1 1.9 -0.3 -0.1 -2.0 0.3
Medication: Atenolol 0.7 0.9 3.1 -0.2 1.3 -1.8 0.5 -0.3 0.6 0.9
Medication: Levothyroxine sodium 0.5 0.8 1.4 0.7 -0.2 0.7 -1.0 -1.1 -0.8 1.2
Sitting height 0.8 5.8 14.5 -3.0 -1.8 -1.5 -0.3 3.4 -0.2 -3.8
Chronic bronchitis/emphysema (father) 2.3 2.7 9.4 0.6 3.1 2.1 1.7 -0.2 1.0 1.0
High blood pressure (mother) 1.0 1.3 5.5 0.5 0.7 1.4 -0.6 -0.6 -2.3 0.7
Body mass index (BMI) 2.6 11.1 22.4 2.7 4.0 0.6 2.0 -2.8 4.4 4.7
Impedance of leg (left) 0.8 3.9 6.4 -1.9 -2.5 0.0 2.4 2.4 -1.2 -2.0
Leg predicted mass (left) 0.4 2.1 6.7 0.5 2.0 -0.5 0.7 -1.4 2.6 1.1
Trunk fat mass 2.3 10.1 22.5 2.1 3.3 -0.1 3.4 -2.0 4.7 4.1
Waist circumference 1.4 5.0 11.1 1.7 2.3 0.4 2.0 -2.0 2.8 3.3
Number of incorrect matches in round 0.9 1.5 2.9 0.9 1.4 1.7 0.5 -0.8 1.5 1.2
Past tobacco smoking 0.3 0.5 1.6 -1.3 -0.1 0.5 -1.1 -0.3 0.2 -0.3
Alcohol usually taken with meals 0.9 1.4 3.7 -0.5 -1.9 1.5 -0.1 0.9 -1.7 -0.1
Nervous feelings 0.8 1.5 4.3 1.0 0.1 -1.7 -0.2 1.3 1.0 -2.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.1 0.3 -0.1 -0.1 0.6 0.6 -1.1 -0.9
Hearing difficulty/problems with background noise 1.2 1.9 4.0 -0.2 1.6 1.6 1.7 0.4 2.0 0.8
Hair/balding pattern: Pattern 2 0.8 1.0 5.5 -0.9 -0.1 0.4 -0.1 2.4 -0.3 -0.4
Had menopause 0.3 0.4 1.9 -0.1 0.5 0.3 -1.4 -0.6 -0.6 0.0
Had other major operations 1.3 1.6 5.9 -0.6 1.4 2.4 -1.3 -1.0 -0.4 0.6
Forced vital capacity (FVC) 0.8 3.3 7.1 -1.8 -1.0 1.0 2.7 1.9 0.7 -2.6
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.5 0.0 -1.2 0.2 0.6 1.1 -0.5 -0.2
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.2 1.5 1.1 0.2 0.0 -1.1 -0.0 1.0
Qualifications: None of the above 2.3 4.9 13.7 3.4 0.5 0.9 -1.5 -2.2 -0.4 3.7
Financial difficulties in last 2 years 0.4 0.5 1.2 -1.1 0.7 -0.1 0.7 0.7 0.6 0.5
Mouth/teeth dental problems 0.6 0.9 3.8 -0.5 -1.3 -0.6 0.3 -0.1 -1.9 -0.2
Heart attack 1.0 1.3 6.2 -0.3 0.4 0.3 -2.5 -0.7 -1.4 0.1
Allergy 0.9 2.1 8.4 -0.3 -0.8 -1.8 -1.4 0.5 -2.9 -0.1
Pain all over the body in last month 0.7 0.7 2.6 0.4 1.3 0.6 1.6 0.2 0.3 0.4
Diabetes (self-reported) 1.2 1.9 3.3 1.5 1.5 1.1 0.1 -1.8 -1.0 1.8
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 5.1 1.5 1.7 2.1 0.5 -1.6 1.7 2.2
Medication: Ramipril 0.5 0.6 2.3 0.2 -0.9 -0.3 -1.5 0.7 -0.7 -0.2
Medication: Simvastatin 0.3 0.4 1.2 -0.9 -0.6 -0.3 -0.3 0.2 -1.1 -0.4
Fluid intelligence score 2.5 5.3 12.5 -3.5 -2.1 -0.8 -1.4 2.5 0.2 -3.4
Illnesses of siblings 0.6 0.8 4.5 0.9 0.0 0.0 -0.2 -2.1 0.0 0.6
Neuroticism score 1.0 2.0 8.5 1.4 0.0 -0.7 1.6 2.9 0.4 -0.7
Weight 1.5 7.1 17.3 1.5 3.3 0.1 2.7 -1.7 4.2 3.1
Impedance of arm (right) 0.6 2.6 5.8 -0.7 -2.3 -1.3 0.5 1.5 -2.4 -1.6
Arm fat percentage (right) 2.9 11.4 24.6 3.1 3.8 0.3 2.9 -2.7 4.0 5.0
Trunk fat-free mass 0.2 1.3 4.8 -0.3 1.5 -0.2 1.2 -0.4 2.2 0.0
Hip circumference 1.0 4.3 8.5 1.1 2.5 0.1 2.4 -0.8 2.9 2.7
Time employed in main current job 0.5 0.6 3.2 0.5 -0.2 -0.1 -0.8 0.1 1.8 -0.2
Alcohol intake versus 10 years previously 0.2 0.3 1.0 0.4 0.9 0.5 -0.2 0.1 -1.0 0.2
Father’s age at death 2.9 3.9 10.3 -1.1 -3.0 0.6 -3.2 -2.4 -0.7 -0.8
Worrier / anxious feelings 0.7 1.4 4.1 -0.3 0.2 -0.9 0.6 2.0 -0.6 -2.0
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.9 -0.1 0.2 0.9 0.8 -0.1 0.5 0.1
Falls in the last year 0.9 1.2 2.4 0.8 -0.4 1.3 0.3 -1.1 1.4 1.6
Hair/balding pattern: Pattern 3 1.7 2.6 7.5 2.5 0.7 1.3 -0.5 -2.7 0.4 1.4
Number of live births 2.4 3.4 9.5 -2.3 -0.9 0.9 0.6 2.7 -0.0 -3.1
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 3.8 -1.7 -0.9 0.4 2.0 1.2 1.0 -1.9
Pulse rate 0.5 0.9 2.6 0.3 0.2 1.6 -0.4 -1.0 -0.2 1.6
Happiness 1.3 1.5 4.8 -0.3 -1.1 -0.6 1.4 2.2 -0.8 -1.4
Noisy workplace 2.4 2.9 5.4 2.1 1.8 1.5 1.3 -2.3 0.9 1.7
Qualifications: A levels/AS levels or equivalent 2.2 4.9 15.8 -3.1 -2.0 -0.9 -0.1 1.1 -1.7 -4.0
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.8 -0.8 -1.9 -0.9 0.0 0.6 -0.9 -1.9
Mouth/teeth dental problems: Dentures 0.8 1.3 3.2 0.8 -0.4 1.0 -1.8 -0.4 -1.6 1.1
Asthma 0.9 1.7 5.5 1.3 -0.2 2.3 1.7 -0.5 1.3 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.9 -0.1 -0.3 0.7 0.3 1.4 -0.7 0.3
Medication: Cholesterol lowering 0.2 0.3 0.7 -0.2 0.6 0.7 0.4 -0.4 -0.7 0.9
Depression (self-reported) 1.5 1.8 4.6 1.7 1.6 0.1 2.1 0.1 1.4 0.6
Medication: Lansoprazole 2.5 2.8 9.6 1.3 0.3 0.5 -2.0 -3.1 -0.3 2.1
Prospective memory result 3.0 3.7 9.8 1.4 3.1 1.2 1.3 -2.4 1.4 1.8
Lung cancer (father) 1.4 1.6 4.7 2.2 1.7 -0.2 1.6 -0.3 0.8 -0.3
Illnesses of mother 1.1 1.3 4.3 0.9 -0.9 -1.3 0.5 1.2 2.1 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 4.3 -2.1 -1.7 0.6 1.0 1.2 0.1 -1.9
Pulse wave Arterial Stiffness index 1.8 2.1 7.0 -0.4 2.6 0.5 1.6 -1.2 1.6 0.8
Impedance of arm (left) 0.5 2.4 5.5 -0.5 -2.3 -1.1 -0.0 1.5 -2.3 -1.3
Arm fat mass (right) 2.3 9.6 17.7 2.5 3.7 0.2 2.5 -2.4 4.2 4.2
Trunk predicted mass 0.2 1.4 5.0 -0.3 1.6 -0.2 1.3 -0.4 2.2 0.0
Standing height 0.4 4.1 11.3 -2.6 -1.6 -1.0 1.8 2.0 0.3 -3.4
Length of working week for main job 0.4 0.5 1.5 0.4 0.1 -1.2 0.1 -0.6 0.9 -0.6
Exposure to tobacco smoke at home 1.4 1.5 4.0 -1.5 2.0 1.2 1.5 0.2 0.5 -0.7
Breastfed as a baby 1.4 1.8 9.4 0.1 0.3 -0.5 0.1 -0.7 3.1 -1.5
Tense / ‘highly strung’ 1.1 1.9 5.3 -0.7 -1.0 -0.7 0.2 2.3 -1.1 -2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 3.1 0.0 -1.0 -0.1 1.5 1.7 -0.5 -1.5
Hair/balding pattern: Pattern 4 0.6 1.5 5.3 2.3 0.2 0.3 -0.3 -2.2 -0.4 -0.4
Birth weight of first child 1.2 2.1 8.4 -0.8 -0.8 -0.6 -0.0 2.9 -0.5 -2.2
Peak expiratory flow (PEF) 0.7 1.7 7.9 -0.8 0.2 0.6 1.7 0.0 2.8 -0.3
Pulse wave reflection index 0.1 0.1 0.4 -0.5 0.3 -0.3 -0.2 0.0 -0.0 -0.6
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.3 -0.7 0.7 -0.7 0.9 -0.1 1.2 -0.8
Loud music exposure frequency 1.4 1.5 4.2 0.1 1.4 1.1 2.0 -0.1 1.6 0.7
Qualifications: O levels/GCSEs or equivalent 3.5 5.5 14.4 -3.6 -1.3 -0.6 1.7 2.4 0.7 -3.8
Mouth/teeth dental problems: Bleeding gums 1.7 2.3 10.4 0.9 1.8 0.2 1.1 0.4 3.2 0.2
Blood clot in the leg (DVT) 2.1 2.7 7.8 0.2 1.9 0.1 2.3 -0.9 2.8 0.9
Medication: Paracetamol 1.1 1.8 5.1 2.2 -0.6 1.2 -0.9 -1.4 -0.4 1.8
Headache pain in last month 0.8 1.4 4.3 0.8 0.9 1.4 0.0 -0.5 1.5 2.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.7 0.3 -0.8 0.5 -0.4 -0.9 0.7 -0.8
Glaucoma (self-reported) 1.2 1.4 4.1 0.7 0.1 -0.1 -2.0 -1.9 -1.3 0.2
Gout (self-reported) 1.4 1.9 5.5 1.2 0.6 0.9 0.4 -2.0 -1.0 2.3
Hypothyroidism/myxoedema (self-reported) 2.0 3.9 11.1 2.7 1.0 0.8 -0.6 -2.6 -0.0 3.3
Medication: Amlodipine 0.2 0.3 1.0 -0.2 0.8 -1.0 -0.8 -0.4 0.3 -0.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.0 0.1 0.8 0.9 1.2 -0.1 1.4 0.8
Birth weight 0.5 1.1 2.2 0.6 0.8 -1.2 1.5 0.9 1.5 0.1
Chronic bronchitis/emphysema (mother) 2.1 2.4 5.3 2.0 2.3 1.0 1.1 -1.8 0.1 1.5
High blood pressure (siblings) 0.5 0.7 2.1 -1.4 -0.1 0.1 0.3 1.0 0.6 -1.0
Forced vital capacity (FVC), Best measure 0.9 3.3 7.0 -2.2 -1.3 1.2 2.0 2.0 0.0 -2.6
Body fat percentage 2.9 11.4 22.8 2.6 3.4 0.5 3.6 -2.2 4.6 4.8
Leg fat percentage (right) 3.2 11.7 23.8 2.5 3.5 1.1 3.7 -2.1 4.5 4.9
Arm fat-free mass (right) 0.4 2.1 8.8 -0.3 1.7 0.1 1.6 -0.6 3.0 0.5
Exposure to tobacco smoke outside home 1.3 1.7 4.3 0.4 1.7 1.0 0.0 -2.1 0.2 1.9
Comparative body size at age 10 0.1 0.3 1.1 0.5 0.2 -0.3 -1.0 0.6 0.1 0.4
Number of full brothers 0.8 0.9 3.4 0.6 1.0 1.8 1.2 -0.1 0.1 0.5
Worry too long after embarrassment 1.0 1.7 4.3 1.6 -0.0 0.3 1.6 2.1 1.5 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 3.8 0.8 1.0 -0.5 1.7 1.9 -0.7 -0.7
Wheeze or whistling in the chest in last year 0.8 1.4 4.3 0.7 1.0 2.1 0.8 -0.3 1.0 1.4
Number of children fathered 0.3 0.3 1.0 -0.6 -0.2 -0.6 0.4 -0.2 1.0 0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 4.5 1.4 -0.2 0.0 0.7 1.0 -2.1 0.1
Age at first live birth 0.8 1.4 3.9 -1.7 -2.0 -0.5 -0.7 0.6 -0.8 -1.1
Pulse wave peak to peak time 1.8 2.2 8.0 0.2 -2.8 -0.6 -1.3 1.3 -1.5 -1.0
Health satisfaction 0.6 0.8 4.8 0.2 0.0 0.3 0.2 -2.2 -0.0 0.7
Shortness of breath walking on level ground 0.8 1.0 2.1 1.0 1.5 0.0 0.4 -1.4 0.4 1.3
Qualifications: College or University degree 2.2 7.0 19.8 -2.8 -2.5 -1.8 -1.5 1.8 -2.4 -4.5
Eye problems/disorders: None of the above 0.3 0.3 1.3 -0.3 0.0 -1.1 0.7 -0.2 0.4 -0.5
Mouth/teeth dental problems: Loose teeth 1.2 1.4 6.0 0.1 2.5 0.5 0.8 -0.4 1.5 1.0
Emphysema/chronic bronchitis 0.3 0.4 1.2 -0.2 0.6 -1.0 -0.1 -0.1 1.1 -0.4
Medication for pain relief, constipation, heartburn 1.5 2.5 5.0 -1.4 -1.4 -2.1 0.3 1.8 1.0 -2.2
Neck or shoulder pain in last month 0.6 0.8 2.5 1.6 -0.6 -0.0 0.8 -0.1 1.3 0.6
Medication: Blood pressure 0.5 0.9 2.4 -0.5 -0.2 -1.6 0.1 1.2 -1.5 0.5
Angina (self-reported) 0.7 1.0 2.0 -1.3 -0.0 -0.1 -1.1 -1.4 -1.4 -0.0
Migraine (self-reported) 0.3 0.4 1.5 -0.5 -0.4 1.2 0.1 0.2 0.6 -0.2
Medication: Ibuprofen 0.8 1.0 2.8 -1.1 -0.4 0.3 0.2 1.7 -1.5 -0.7
Medication: Allopurinol 2.0 2.6 7.3 0.8 1.3 1.4 -0.1 -2.3 -1.2 2.7
Medication: Omeprazole 2.6 3.1 8.8 1.9 3.0 1.3 1.1 -1.2 1.8 1.2
Medication: Seretide 50 evohaler 0.7 0.8 5.0 -0.1 -0.1 2.2 0.0 -0.8 0.3 -0.0
Mean time to correctly identify matches 0.4 0.8 4.0 0.7 0.2 -0.2 -0.2 -0.5 2.0 1.0
Heart disease (mother) 1.3 1.6 3.2 -0.2 1.8 1.6 -0.5 -1.8 0.4 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.0 0.8 -0.2 -0.8 -0.6 -1.4 0.3 0.7
Whole body fat mass 2.5 10.4 22.1 2.1 3.5 0.3 3.3 -2.2 4.7 4.2
Leg fat mass (right) 2.7 10.4 19.4 2.3 3.5 0.7 3.5 -2.0 4.4 4.3
Arm predicted mass (right) 0.5 2.5 9.6 -0.2 1.8 0.1 1.9 -0.8 3.1 0.6
Pulse rate, automated reading 0.3 1.0 3.1 -0.9 -0.1 1.8 -1.1 -1.1 0.3 0.9
Alcohol intake frequency. 0.2 0.5 2.2 -0.5 1.5 0.9 -0.4 -0.0 -0.3 -0.1
Comparative height size at age 10 0.2 1.4 3.6 -0.8 -0.5 0.5 1.9 1.6 0.5 -1.5
Number of full sisters 1.3 1.6 3.2 1.6 -1.3 0.9 -1.3 -0.3 -1.8 0.9
Suffer from ‘nerves’ 0.4 0.6 2.1 1.5 0.5 -0.3 0.1 1.2 0.2 -0.7
Overall health rating 1.5 3.3 8.6 2.8 0.3 0.5 0.0 -2.5 0.7 2.9
Chest pain or discomfort 0.3 0.4 0.7 0.7 0.6 0.5 0.1 0.8 -0.8 -0.3
Had major operations 0.4 0.5 1.4 0.8 0.1 1.2 -0.5 0.4 -0.8 0.1
Age at last live birth 2.0 2.9 6.7 -2.6 -2.3 -0.5 -1.0 1.7 -1.1 -1.7
Family relationship satisfaction 1.2 1.5 5.9 0.6 -0.5 -1.1 0.7 2.4 0.1 -1.5
Leg pain on walking 0.8 1.0 3.0 0.6 0.6 0.9 1.0 -1.7 0.1 1.2
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.8 0.3 1.3 0.8 1.3 0.2 0.1 1.0
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.5 0.6 -0.8 -0.0 -0.1 0.0 -1.0 1.2
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.3 1.7 1.8 0.2 -0.0 -1.1 1.7 0.8
Medication: Aspirin 0.7 1.0 2.2 -0.1 1.5 1.3 -0.3 -1.1 -1.1 0.3
Supplements: Vitamin C 0.2 0.2 0.9 0.4 -0.3 1.0 -0.3 -0.2 -0.4 0.4
Knee pain experienced in last month 1.9 2.9 5.9 2.4 2.1 1.8 0.9 -1.7 0.5 1.6
Hypertension (Self-reported) 0.4 1.0 4.0 -0.3 0.5 -2.0 -0.3 1.1 -1.2 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.2 5.8 1.7 0.3 1.0 -1.3 -2.4 -0.2 2.0
Illnesses of father: Heart disease 1.3 1.8 6.9 -2.6 -0.2 0.9 0.8 0.5 1.8 -0.7
Illnesses of siblings: Diabetes 0.6 0.7 2.8 0.1 -0.8 -0.4 -0.9 0.8 -1.7 0.2
Smoking status: Previous 0.5 0.7 1.9 1.1 0.3 -0.7 1.4 0.9 -0.1 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 2.0 -1.4 -1.1 -1.0 0.6 1.0 -1.0 -1.4
Whole body fat-free mass 0.3 1.6 6.2 -0.1 1.7 -0.4 1.1 -0.8 2.5 0.3
Leg fat-free mass (right) 0.3 1.6 6.0 0.1 1.8 -0.4 0.4 -1.1 2.4 0.5
Arm fat percentage (left) 2.7 10.8 25.2 3.1 3.5 0.2 2.4 -2.5 4.0 5.0
Average weekly red wine intake 0.9 1.4 4.4 -0.2 -1.3 0.5 -0.2 2.1 -1.3 -1.2
Handedness (chirality/laterality): Left-handed 1.0 1.2 3.4 1.1 0.2 1.6 -0.6 0.4 -1.8 0.8
Mood swings 0.8 1.5 3.9 1.6 -1.0 -1.0 0.6 2.0 -1.0 -1.0
Loneliness, isolation 1.3 1.8 7.4 1.0 1.0 0.7 0.7 2.7 -1.5 -0.3
Long-standing illness, disability or infirmity 0.4 0.6 2.9 0.6 0.1 0.6 -0.1 -1.7 0.2 0.9
Ever had bowel cancer screening 0.5 0.6 1.7 -0.4 -0.6 -0.7 -0.8 -0.5 1.3 0.5
Diabetes diagnosed by doctor 1.8 2.9 5.7 1.5 2.3 0.9 0.6 -2.4 -1.1 2.1
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 3.7 -0.8 -0.0 0.1 0.5 1.9 0.1 -1.2
Friendships satisfaction 1.1 1.4 4.1 -0.4 -1.3 -1.0 -0.8 2.0 -0.3 -1.4
Qualifications: nursing, teaching 1.8 2.7 9.5 -2.3 -0.3 -0.6 0.7 1.4 -1.3 -3.1
Commuting to job workplace: Walk 0.5 0.6 1.9 0.0 0.3 -1.0 0.5 -0.9 1.4 -0.0
Eye problems/disorders: Cataract 0.3 0.4 1.4 -0.6 -1.2 0.4 -0.6 0.0 0.2 0.4
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.0 -0.9 -0.7 -1.2 -0.2 0.4 0.1 -1.4
Medication for cholesterol 0.5 0.8 2.9 -0.5 -0.9 -0.0 1.7 0.8 0.9 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 4.6 -0.3 0.1 2.1 -0.7 -1.3 -0.3 0.9
Back pain experienced in last month 0.5 0.7 3.5 0.2 -0.3 -0.8 -0.3 -0.3 1.9 -0.4
Mineral and other dietary supplements 1.3 1.7 4.5 -1.3 2.1 0.1 1.3 1.3 1.2 -0.8
Breast cancer (self-reported) 0.1 0.1 0.2 -0.1 0.3 0.1 0.5 -0.4 -0.5 -0.1
Asthma (self-reported) 0.8 1.6 5.2 1.4 -0.1 2.3 1.3 -0.5 1.4 0.3
Osteoporosis (self-reported) 0.4 0.5 2.1 -0.5 0.1 -0.1 -1.4 -0.6 -0.8 -0.5
Osteoarthritis (self-reported) 1.1 1.5 7.1 0.7 0.8 0.1 0.1 -1.3 2.7 0.7
Medication: Aspirin 0.8 1.1 2.3 -0.4 1.5 1.5 -0.2 -1.4 -0.9 0.3
Medication: Gliclazide 1.5 1.7 4.3 1.5 0.8 -0.3 -1.3 -2.1 -0.5 1.6
Illnesses of father: None of the above (group 1) 1.6 2.0 8.4 1.1 -2.9 -1.9 -0.1 0.2 0.4 -0.7
Smoking status: Current 0.5 0.8 2.6 -0.1 -0.5 -0.3 -0.7 -1.6 -1.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 4.0 -0.0 -1.4 1.0 -2.0 -0.9 -1.3 0.8
Whole body water mass 0.3 1.7 6.5 -0.1 1.8 -0.4 1.2 -0.9 2.5 0.3
Leg predicted mass (right) 0.3 1.6 6.2 0.1 1.9 -0.4 0.3 -1.1 2.5 0.5
Arm fat mass (left) 2.3 9.6 18.1 2.5 3.5 0.2 2.6 -2.3 4.3 4.2
Number of self-reported non-cancer illnesses 0.9 1.6 3.7 1.6 1.6 0.2 -0.3 -1.9 -0.2 1.4
Average weekly champagne plus white wine intake 0.6 0.8 2.1 1.5 0.2 0.5 -0.4 -0.3 -1.1 1.2
Miserableness 0.8 1.4 6.1 1.3 0.2 -0.9 1.1 2.5 0.4 0.1
Guilty feelings 1.2 1.8 6.9 -0.1 1.1 1.3 2.6 1.6 0.6 -0.4
Wears glasses or contact lenses 0.5 0.5 2.8 -0.1 -1.7 0.2 -0.3 0.8 0.1 -0.3
Ever taken oral contraceptive pill 2.7 3.0 6.4 -2.5 -1.3 -0.6 1.9 1.6 -0.0 -2.5
Hearing aid user 1.4 1.6 6.5 -1.2 -0.5 0.3 1.2 -0.6 2.5 -1.1
Mother’s age at death 1.7 2.2 4.8 -1.1 -1.7 -1.7 -0.5 1.5 -0.8 -2.2
Financial situation satisfaction 0.3 0.4 0.7 -0.1 0.7 0.6 0.9 -0.7 0.6 0.5
Tinnitus: Yes, now most or all of the time 2.0 2.3 12.8 -0.4 0.9 -0.2 1.5 -0.3 3.6 -0.4
Commuting to job workplace: Public transport 0.4 0.5 1.7 0.2 0.4 -0.0 -1.3 0.8 -0.2 -0.8
Eye problems/disorders: Glaucoma 1.7 2.0 6.1 1.3 0.6 -0.2 -2.5 -1.9 -1.0 0.9
Medication: Blood pressure 0.4 0.8 2.5 1.0 0.4 -0.6 -1.2 0.1 -1.6 -0.1
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.2 -0.3 0.1 0.8 -1.1 -0.8 -0.0 -0.6
Supplements: Fish oil (including cod liver oil) 1.4 1.9 4.9 1.5 -1.6 -0.3 -1.1 -2.2 -0.4 1.5
High cholesterol (Self-reported) 0.4 0.6 1.8 -0.6 -0.3 -1.0 -1.4 -1.0 -0.0 -0.3
Medication: Bendroflumethiazide 0.8 1.2 3.0 -0.4 -1.1 0.7 -0.9 1.5 -1.7 0.6
Medication: Paracetamol 0.6 0.9 1.6 1.2 -1.3 0.7 -0.8 -1.1 -1.0 0.7
Medication: Lisinopril 1.1 1.4 3.4 -1.7 -0.1 -0.3 0.1 0.3 -1.8 -1.8
Medication: Atorvastatin 0.7 0.8 2.7 -1.0 0.8 1.6 0.6 0.3 -0.1 0.9
Illnesses of father: High blood pressure 0.5 0.6 2.9 -0.9 0.5 1.7 0.4 -0.2 -0.1 -0.2
Alcohol drinker status: Never 0.7 0.8 2.9 -0.7 -1.0 -0.6 -1.1 -0.0 -1.7 -0.2
Ever smoked 0.3 0.5 1.5 1.2 0.0 -0.6 1.0 -0.1 -0.8 -0.0
Basal metabolic rate 0.5 2.5 8.2 0.4 2.1 -0.3 1.6 -1.1 2.9 1.0
Leg fat percentage (left) 2.8 10.2 21.3 2.1 3.2 1.0 3.6 -1.8 4.6 4.2
Arm fat-free mass (left) 0.5 2.8 8.8 0.0 2.2 0.2 2.1 -0.8 3.0 0.6
Number of operations (self-reported) 1.5 2.3 11.0 0.3 0.7 3.3 -1.3 -1.1 -0.9 0.8
Average weekly beer plus cider intake 2.6 3.8 15.4 1.2 3.9 -0.3 1.3 0.3 2.1 1.8
Irritability 0.7 1.2 3.5 -0.3 -0.5 -0.2 1.1 1.9 -0.5 -1.8
Risk taking 2.3 3.3 10.4 -2.1 0.7 1.7 3.2 1.2 1.8 -0.6
Ever had prostate specific antigen (PSA) test 0.7 0.9 2.7 -0.8 -1.3 0.3 -0.7 0.4 -1.6 0.3
Fractured/broken bones in last 5 years 1.3 1.7 3.4 0.6 1.0 1.2 1.9 0.2 1.6 1.8
Age started oral contraceptive pill 0.3 0.3 0.7 0.7 -0.4 -0.2 -0.4 -0.7 -0.9 -0.4
Diastolic blood pressure, automated reading 0.2 0.6 1.0 -0.9 1.0 -1.0 0.8 0.3 0.9 0.4
Ever depressed for a whole week 0.4 0.5 1.7 1.3 0.0 0.4 0.3 0.0 -1.1 0.3
Unable to work because of sickness or disability 1.2 1.5 6.0 0.4 0.8 -0.3 -0.0 -2.4 1.1 1.5
Commuting to job workplace: Cycle 0.7 0.9 2.4 -0.5 1.6 0.7 0.7 -0.7 1.2 -0.7
Myopia 6.9 9.9 16.6 -2.6 -4.1 -1.7 -3.4 3.9 -3.4 -2.4
Vascular/heart problems diagnosed by doctor 0.4 1.0 2.2 -0.3 -1.1 1.3 0.7 0.3 1.0 -1.5
Cholesterol lowering medication 0.9 1.3 3.0 -0.6 0.3 1.1 -1.7 -1.7 -1.2 0.3
Medication: Omeprazole (e.g. Zanprol) 4.0 4.9 8.5 2.4 2.9 2.0 1.3 -1.9 2.5 2.1
Pain experienced in last month 1.3 2.2 7.1 -2.7 -0.9 -1.4 -0.6 0.7 -0.7 -1.9
Supplements: Calcium 0.2 0.3 0.9 -0.2 0.3 0.6 -0.3 0.5 0.2 -0.9
Basal cell carcinoma (self-reported) 2.4 2.8 7.6 -1.4 -2.5 0.1 -2.8 -0.5 -0.6 -1.9
Heart attack/myocardial infarction (self-reported) 1.1 1.4 6.5 -0.4 0.4 0.3 -2.5 -1.1 -1.3 0.3
Deep venous thrombosis (DVT) (self-reported) 1.9 2.5 8.2 0.3 1.7 0.1 2.1 -0.9 2.9 0.8
Heart disease (siblings) 2.0 2.4 6.5 1.9 2.0 0.8 -0.1 -0.8 1.3 2.5
Alcohol drinker status: Previous 1.1 1.2 5.6 0.6 -0.5 -1.0 -2.4 -0.8 -0.2 0.9
Pack years of smoking 0.4 0.5 2.1 -0.5 1.5 -0.2 -0.3 -0.7 0.6 -0.7
Impedance of whole body 0.5 2.7 6.3 -1.0 -2.5 -0.6 1.2 1.9 -1.8 -1.7
Leg fat mass (left) 2.4 9.3 20.2 2.0 3.4 0.5 3.4 -1.9 4.5 3.8
Arm predicted mass (left) 0.6 3.1 9.2 -0.1 2.4 0.5 2.2 -1.1 3.0 0.5