Hub : Genes

ANTXR2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0550	0.0260	8.3e-03	0.001	0.008	0.031	0.012	0.006	2.0e-01	3.5e-02	9.2e-05	1.0e-02	4.9e-02
2	GTEx	Adipose Subcutaneous	0.0920	0.0410	5.5e-03	0.053	NA	0.074	NA	0.064	3.6e-05	NA	1.1e-06	NA	5.7e-06
3	GTEx	Cells Transformed fibroblasts	0.1670	0.0590	4.2e-03	0.100	NA	0.088	NA	0.072	6.7e-08	NA	4.2e-07	NA	4.2e-06
4	METSIM	Adipose	0.0438	0.0201	3.7e-03	0.010	0.005	-0.001	0.006	0.002	1.0e-02	4.6e-02	5.5e-01	3.5e-02	1.3e-01
5	YFS	Blood	0.0331	0.0119	2.8e-05	0.017	0.021	0.015	0.022	0.014	2.6e-06	1.1e-07	5.9e-06	6.9e-08	1.6e-05
6	TCGA	Colon Adenocarcinoma	0.0890	0.0510	6.9e-03	0.014	0.003	-0.003	NA	0.020	5.1e-02	1.9e-01	4.9e-01	NA	2.3e-02
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.0720	0.0370	3.0e-03	0.077	0.021	0.032	NA	0.069	6.7e-06	1.3e-02	3.2e-03	NA	2.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.8	1.2	3.5	-0.7	0.2	1.9	-1.0	1.3	-1.2	0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	2.2	0.4	-1.1	1.5	-0.6	0.3	-0.8	-0.1
Depressed Affect (Nagel 2018)	0.9	1.8	5.8	2.4	-0.1	-0.5	1.2	2.3	-0.0	-0.0
Depression (Nagel 2018)	0.8	1.2	2.6	1.4	1.1	0.1	1.6	1.0	0.8	-0.8
Intelligence (Savage-Jansen 2018)	1.7	5.1	12.4	-1.9	-2.0	0.4	-1.0	3.5	-2.3	-3.0
Neuroticism (Nagel 2018)	1.0	2.2	7.7	1.2	-0.4	-0.6	1.9	2.8	0.7	-1.4
Schizophrenia (2018)	0.3	0.7	2.5	1.0	-1.6	0.5	-0.0	-0.6	-0.1	-0.6
Schizophrenia vs Biploar Disorder	1.0	1.4	3.7	1.4	-1.2	-1.9	-1.2	-0.7	-0.6	-0.5
Worry (Nagel 2018)	1.0	2.2	7.0	-0.1	-0.3	-1.0	0.7	2.4	1.0	-2.6
Alzheimer’s Disease (in mother)	1.1	1.3	5.2	-1.7	-0.4	-0.2	-2.3	-0.7	-0.7	-0.1
Alzheimer’s Disease (in father)	2.7	2.9	8.9	-1.0	-1.6	-3.0	-1.3	0.1	-1.8	-1.8
Alzheimer’s Disease (including proxy)	2.3	3.4	8.4	-1.8	-0.9	-2.5	-2.9	-0.7	-1.9	-1.0
Crohns Disease (2017)	1.3	2.8	8.2	1.3	1.5	2.9	0.9	-0.1	-1.2	2.4
Irritable Bowel Disease (IBD)	0.5	1.2	3.4	1.0	0.2	1.7	1.0	0.1	0.1	1.9
Ulcerative Colitis (UC)	0.4	0.8	2.0	0.8	-0.9	-0.1	0.9	0.4	1.4	1.1
Major Depression (MDD)	1.3	1.6	4.8	1.6	0.8	0.9	2.2	1.3	-0.0	0.7
Reaction Time	0.2	0.4	1.0	0.6	-0.2	0.4	-0.4	-0.2	1.0	1.0
Verbal and Numeric Reasoning (VNR)	2.3	5.4	12.7	-3.6	-2.4	0.0	0.4	2.5	-0.9	-3.5
Breast Cancer	1.0	2.4	6.3	-0.7	0.5	-1.5	2.0	2.5	1.2	-1.5
Ovarian Cancer	0.1	0.1	0.4	0.4	0.1	0.0	0.6	-0.6	-0.2	0.0
Prostate Cancer	1.2	1.7	3.5	1.4	1.9	1.1	1.3	-0.7	0.1	1.7
Age at First Birth	1.0	1.4	3.9	-1.3	-0.9	0.0	0.6	2.0	-0.3	-1.7
Bipolar Disorder (2011)	0.6	0.6	1.3	1.0	0.5	-0.1	0.5	0.6	1.0	1.1
Body Mass Index (BMI) (2010)	0.4	0.6	2.2	0.6	0.7	1.5	1.0	-0.2	0.2	-0.2
Coronary Artery Disease (CAD)	0.2	0.3	0.8	0.2	0.9	0.5	-0.6	0.5	0.2	0.6
Crohns Disease (2012)	0.6	1.0	2.9	1.1	0.6	1.0	-1.0	-0.3	-0.7	1.7
Mean Putamen Volume	0.2	0.2	0.5	0.1	0.5	0.2	0.6	-0.1	0.7	-0.4
Fasting Glucose	0.6	0.7	1.4	-0.9	-1.0	1.0	-0.2	0.4	-0.9	-1.2
HbA1C	1.4	1.5	6.5	2.5	0.3	-1.1	-1.3	-0.2	1.0	0.4
HDL Cholesterol	0.2	0.3	1.3	-0.1	0.4	-0.4	0.5	-0.1	-0.4	1.1
LDL Cholesterol	0.3	0.4	1.6	0.2	-0.6	-0.1	-1.2	-0.2	0.1	-1.0
Lupus	1.2	1.8	3.1	1.4	1.0	1.5	-0.6	-1.1	-1.8	1.7
Neuroticism (2016)	0.2	0.3	1.6	0.1	0.6	-0.3	-0.5	0.1	-1.3	0.1
Primary Biliary Cirrhosis	1.7	2.4	4.8	2.2	-0.9	-0.6	-1.5	-1.7	-2.0	1.4
Rheumatoid Arthritis	3.0	4.2	14.6	2.8	0.5	1.2	0.2	-1.8	1.4	3.8
Schizophrenia (2014)	0.2	0.4	1.0	0.8	-0.7	1.0	-0.5	-0.3	-0.2	-0.4
Triglycerides	0.3	0.5	1.1	-0.9	0.5	0.6	0.5	1.0	-0.2	-0.7
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.7	-2.2	0.2	1.4	-0.2	0.9	-1.1	-1.1
Ulcerative Colitis	0.5	0.8	3.1	1.1	-0.8	0.2	0.4	0.0	0.5	1.8
Blood Eosinophil Count	0.9	7.0	13.5	1.9	3.4	-0.1	2.2	-2.3	3.1	3.7
Blood Platelet Count	0.0	0.4	1.5	-1.2	0.0	0.5	0.6	0.8	-0.1	-0.2
Blood Red Count	0.1	0.8	2.8	-1.3	0.2	-0.9	-0.4	0.1	-1.7	-0.2
Blood White Count	1.9	14.2	32.9	3.4	4.2	1.9	2.7	-3.5	3.7	5.7
Heel T-Score	0.1	0.9	2.7	-0.0	-1.6	-1.3	-1.0	0.6	-0.8	-0.4
BMI	1.9	11.0	22.7	2.3	4.1	1.4	1.8	-3.5	3.9	4.8
Height	0.5	9.1	22.4	-3.8	-0.9	0.2	3.6	3.6	0.5	-4.7
Waist Hip Ratio (WHR)	0.2	1.0	3.4	0.6	-1.8	-0.2	-0.5	-1.4	-0.9	0.5
Systolic Blood Pressure	0.7	3.5	6.8	-2.6	-0.7	-2.6	-0.7	2.0	-1.6	-1.9
Smoking Status	0.3	0.6	1.5	-0.2	0.3	-0.9	1.2	-0.7	-1.0	-0.6
Allergy or Eczema	0.3	0.8	1.9	0.0	0.2	1.2	1.2	0.2	1.4	-0.9
Cardiovascular Disease	0.5	1.5	4.3	0.1	2.1	-2.1	1.1	0.3	0.1	0.8
Hypothyroidism (self reported)	3.2	7.3	19.6	3.4	2.1	2.2	0.7	-3.1	0.4	4.4
Respiratory disease	0.5	1.0	3.6	0.8	-0.2	1.4	0.9	-0.3	1.9	0.5
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.2	1.8	1.8	0.2	-0.1	-1.8	-0.5	2.0
Lung FEV1/FVC ratio	0.2	0.8	2.3	-1.1	-0.6	-1.5	-0.7	0.0	0.6	-0.7
Lung FVC	0.3	1.6	2.8	1.1	1.4	0.8	1.6	1.1	1.7	-1.0
Neuroticism	0.7	1.8	5.5	1.2	-1.4	0.1	1.4	2.3	0.1	-1.1
Chronotype (morning person)	0.6	1.3	3.1	-0.6	-0.2	1.2	-1.1	-1.5	-1.8	0.9
Hair Pigment	0.0	1.0	2.2	1.4	0.1	0.8	0.9	-1.5	1.1	0.5
Tanning	0.2	2.7	7.1	-2.5	-0.9	-0.5	0.1	1.6	1.2	-2.7
Hand grip strength (left)	1.2	3.2	6.9	-1.6	-2.6	-2.4	-0.9	-0.4	-0.9	-2.4
Number of treatments/medications taken	0.6	1.0	3.0	1.4	-0.0	0.7	-0.6	-1.1	-0.6	1.7
Average weekly spirits intake	3.2	4.0	12.1	1.4	1.4	1.0	2.2	-1.0	3.5	2.1
Sensitivity / hurt feelings	1.1	2.0	6.5	-1.3	-1.0	-0.2	1.5	1.2	2.5	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	0.4	-0.4	0.4	1.1	0.9	-0.3	-0.4
Hearing difficulty/problems: Yes	1.0	1.5	4.0	1.4	1.0	1.1	0.5	-0.6	2.0	1.4
Relative age of first facial hair	1.1	2.3	5.6	-0.1	1.5	2.4	1.6	1.5	1.2	1.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.1	-1.5	0.3	0.2	-0.3	-1.0	-0.9	-0.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.4	-1.5	-0.2	0.8	-0.3	-0.6	1.2	-1.8
Ever had hysterectomy (womb removed)	0.2	0.3	1.3	-0.2	0.7	0.1	-1.1	-0.2	-0.3	0.1
Systolic blood pressure, automated reading	0.2	0.7	4.1	-0.2	-0.3	-2.0	-0.7	0.1	0.1	-0.0
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.8	0.5	0.5	-0.0	1.5	0.8	0.7	1.7
Angina	0.7	0.9	2.6	-1.2	0.3	-0.0	-1.0	-1.6	-1.2	-0.1
Medication for hormone replacement therapy	0.6	0.7	3.6	-0.2	0.7	0.1	0.1	0.4	1.9	0.5
Vitamin and mineral supplements	0.9	1.3	5.1	0.9	0.4	-0.3	-2.2	-0.6	-0.2	1.5
Supplements: Zinc	1.1	1.2	3.5	-0.5	1.3	1.9	0.1	-1.1	1.0	0.7
Medication: Co-codamol	0.2	0.2	1.3	0.0	-1.1	-0.1	-0.0	0.3	0.1	-0.1
Medication: Metformin	1.9	2.7	6.4	1.9	1.9	0.3	-0.2	-2.2	0.6	2.5
Diabetes (father)	1.0	1.3	5.4	-0.6	1.4	2.3	0.6	-0.7	-0.3	0.4
Diabetes (mother)	0.8	1.0	4.4	0.8	-1.1	0.3	-0.1	-0.9	-2.1	0.2
Severe depression (siblings)	0.4	0.5	1.5	0.7	0.5	0.1	0.2	-0.5	-1.2	-0.8
Pack years adult smoking proportion	0.3	0.5	1.7	-0.8	1.3	-0.4	0.2	-0.4	0.4	-0.7
Impedance of leg (right)	0.7	3.3	6.2	-1.5	-2.5	-0.1	2.5	2.1	-1.4	-1.5
Leg fat-free mass (left)	0.4	2.1	6.9	0.5	2.0	-0.5	0.6	-1.4	2.6	1.1
Trunk fat percentage	2.5	9.9	19.8	2.4	3.0	-0.0	3.3	-2.2	4.4	4.5
Hand grip strength (right)	1.4	3.8	9.7	-1.6	-3.1	-2.4	-1.1	-0.2	-0.4	-2.6
Townsend deprivation index at recruitment	0.9	1.3	4.6	0.9	0.2	0.4	-0.8	-2.1	-0.8	1.4
Current tobacco smoking	0.4	0.6	2.8	0.2	-0.1	-0.1	-0.2	-1.7	-1.1	0.0
Average weekly fortified wine intake	0.1	0.1	0.7	-0.1	-0.0	0.0	0.2	0.1	0.8	0.4
Maternal smoking around birth	2.4	3.5	12.6	0.7	3.6	0.2	2.5	0.3	1.9	1.1
Fed-up feelings	0.8	1.4	5.8	2.4	0.9	-0.5	0.3	1.1	-0.6	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.9	8.5	0.7	2.1	-0.1	2.9	1.1	2.3	-0.3
Relative age voice broke	0.1	0.2	1.2	-0.1	-0.5	1.1	-0.1	0.1	-0.1	0.2
Taking other prescription medications	1.9	2.9	6.3	1.9	2.1	1.2	-0.3	-2.1	0.2	2.5
Age when periods started (menarche)	0.2	0.6	2.0	-0.8	0.7	-0.3	1.4	-0.5	0.6	0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.2	-1.0	0.6	0.3	-0.9	-1.0	-1.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.2	0.5	-1.5	-0.2	-0.3	0.5	-0.9	-0.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.1	1.1	0.7	-1.2	1.4	-0.8	1.5	-0.6
Qualifications: CSEs or equivalent	1.2	1.6	5.0	-0.2	1.2	0.1	-0.8	-2.0	-0.1	2.2
Serious illness, injury or assault to yourself	0.6	0.7	1.2	-1.1	0.6	1.1	0.6	-1.0	-0.7	0.6
High blood pressure	0.3	0.9	3.1	0.1	0.8	-1.8	-0.0	0.4	-1.0	1.1
Hayfever, allergic rhinitis or eczema	0.6	1.3	5.0	-0.1	0.9	2.2	0.7	-0.6	1.5	0.1
Multivitamins +/- minerals	1.4	1.7	6.7	-1.2	0.3	-0.3	2.6	0.7	1.1	-1.5
Stomach or abdominal pain in last month	2.5	3.2	8.6	2.1	2.5	1.0	1.2	-0.4	2.9	0.5
Supplements: Glucosamine	0.4	0.5	2.8	-0.1	-1.7	0.5	0.1	-0.6	0.0	-0.5
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.2	-0.7	1.1	1.9	-0.3	-0.1	-2.0	0.3
Medication: Atenolol	0.7	0.9	3.1	-0.2	1.3	-1.8	0.5	-0.3	0.6	0.9
Medication: Levothyroxine sodium	0.5	0.8	1.4	0.7	-0.2	0.7	-1.0	-1.1	-0.8	1.2
Sitting height	0.8	5.8	14.5	-3.0	-1.8	-1.5	-0.3	3.4	-0.2	-3.8
Chronic bronchitis/emphysema (father)	2.3	2.7	9.4	0.6	3.1	2.1	1.7	-0.2	1.0	1.0
High blood pressure (mother)	1.0	1.3	5.5	0.5	0.7	1.4	-0.6	-0.6	-2.3	0.7
Body mass index (BMI)	2.6	11.1	22.4	2.7	4.0	0.6	2.0	-2.8	4.4	4.7
Impedance of leg (left)	0.8	3.9	6.4	-1.9	-2.5	0.0	2.4	2.4	-1.2	-2.0
Leg predicted mass (left)	0.4	2.1	6.7	0.5	2.0	-0.5	0.7	-1.4	2.6	1.1
Trunk fat mass	2.3	10.1	22.5	2.1	3.3	-0.1	3.4	-2.0	4.7	4.1
Waist circumference	1.4	5.0	11.1	1.7	2.3	0.4	2.0	-2.0	2.8	3.3
Number of incorrect matches in round	0.9	1.5	2.9	0.9	1.4	1.7	0.5	-0.8	1.5	1.2
Past tobacco smoking	0.3	0.5	1.6	-1.3	-0.1	0.5	-1.1	-0.3	0.2	-0.3
Alcohol usually taken with meals	0.9	1.4	3.7	-0.5	-1.9	1.5	-0.1	0.9	-1.7	-0.1
Nervous feelings	0.8	1.5	4.3	1.0	0.1	-1.7	-0.2	1.3	1.0	-2.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.1	0.3	-0.1	-0.1	0.6	0.6	-1.1	-0.9
Hearing difficulty/problems with background noise	1.2	1.9	4.0	-0.2	1.6	1.6	1.7	0.4	2.0	0.8
Hair/balding pattern: Pattern 2	0.8	1.0	5.5	-0.9	-0.1	0.4	-0.1	2.4	-0.3	-0.4
Had menopause	0.3	0.4	1.9	-0.1	0.5	0.3	-1.4	-0.6	-0.6	0.0
Had other major operations	1.3	1.6	5.9	-0.6	1.4	2.4	-1.3	-1.0	-0.4	0.6
Forced vital capacity (FVC)	0.8	3.3	7.1	-1.8	-1.0	1.0	2.7	1.9	0.7	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.5	0.0	-1.2	0.2	0.6	1.1	-0.5	-0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.2	1.5	1.1	0.2	0.0	-1.1	-0.0	1.0
Qualifications: None of the above	2.3	4.9	13.7	3.4	0.5	0.9	-1.5	-2.2	-0.4	3.7
Financial difficulties in last 2 years	0.4	0.5	1.2	-1.1	0.7	-0.1	0.7	0.7	0.6	0.5
Mouth/teeth dental problems	0.6	0.9	3.8	-0.5	-1.3	-0.6	0.3	-0.1	-1.9	-0.2
Heart attack	1.0	1.3	6.2	-0.3	0.4	0.3	-2.5	-0.7	-1.4	0.1
Allergy	0.9	2.1	8.4	-0.3	-0.8	-1.8	-1.4	0.5	-2.9	-0.1
Pain all over the body in last month	0.7	0.7	2.6	0.4	1.3	0.6	1.6	0.2	0.3	0.4
Diabetes (self-reported)	1.2	1.9	3.3	1.5	1.5	1.1	0.1	-1.8	-1.0	1.8
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	5.1	1.5	1.7	2.1	0.5	-1.6	1.7	2.2
Medication: Ramipril	0.5	0.6	2.3	0.2	-0.9	-0.3	-1.5	0.7	-0.7	-0.2
Medication: Simvastatin	0.3	0.4	1.2	-0.9	-0.6	-0.3	-0.3	0.2	-1.1	-0.4
Fluid intelligence score	2.5	5.3	12.5	-3.5	-2.1	-0.8	-1.4	2.5	0.2	-3.4
Illnesses of siblings	0.6	0.8	4.5	0.9	0.0	0.0	-0.2	-2.1	0.0	0.6
Neuroticism score	1.0	2.0	8.5	1.4	0.0	-0.7	1.6	2.9	0.4	-0.7
Weight	1.5	7.1	17.3	1.5	3.3	0.1	2.7	-1.7	4.2	3.1
Impedance of arm (right)	0.6	2.6	5.8	-0.7	-2.3	-1.3	0.5	1.5	-2.4	-1.6
Arm fat percentage (right)	2.9	11.4	24.6	3.1	3.8	0.3	2.9	-2.7	4.0	5.0
Trunk fat-free mass	0.2	1.3	4.8	-0.3	1.5	-0.2	1.2	-0.4	2.2	0.0
Hip circumference	1.0	4.3	8.5	1.1	2.5	0.1	2.4	-0.8	2.9	2.7
Time employed in main current job	0.5	0.6	3.2	0.5	-0.2	-0.1	-0.8	0.1	1.8	-0.2
Alcohol intake versus 10 years previously	0.2	0.3	1.0	0.4	0.9	0.5	-0.2	0.1	-1.0	0.2
Father’s age at death	2.9	3.9	10.3	-1.1	-3.0	0.6	-3.2	-2.4	-0.7	-0.8
Worrier / anxious feelings	0.7	1.4	4.1	-0.3	0.2	-0.9	0.6	2.0	-0.6	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.1	0.2	0.9	0.8	-0.1	0.5	0.1
Falls in the last year	0.9	1.2	2.4	0.8	-0.4	1.3	0.3	-1.1	1.4	1.6
Hair/balding pattern: Pattern 3	1.7	2.6	7.5	2.5	0.7	1.3	-0.5	-2.7	0.4	1.4
Number of live births	2.4	3.4	9.5	-2.3	-0.9	0.9	0.6	2.7	-0.0	-3.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.8	-1.7	-0.9	0.4	2.0	1.2	1.0	-1.9
Pulse rate	0.5	0.9	2.6	0.3	0.2	1.6	-0.4	-1.0	-0.2	1.6
Happiness	1.3	1.5	4.8	-0.3	-1.1	-0.6	1.4	2.2	-0.8	-1.4
Noisy workplace	2.4	2.9	5.4	2.1	1.8	1.5	1.3	-2.3	0.9	1.7
Qualifications: A levels/AS levels or equivalent	2.2	4.9	15.8	-3.1	-2.0	-0.9	-0.1	1.1	-1.7	-4.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.8	-0.8	-1.9	-0.9	0.0	0.6	-0.9	-1.9
Mouth/teeth dental problems: Dentures	0.8	1.3	3.2	0.8	-0.4	1.0	-1.8	-0.4	-1.6	1.1
Asthma	0.9	1.7	5.5	1.3	-0.2	2.3	1.7	-0.5	1.3	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.9	-0.1	-0.3	0.7	0.3	1.4	-0.7	0.3
Medication: Cholesterol lowering	0.2	0.3	0.7	-0.2	0.6	0.7	0.4	-0.4	-0.7	0.9
Depression (self-reported)	1.5	1.8	4.6	1.7	1.6	0.1	2.1	0.1	1.4	0.6
Medication: Lansoprazole	2.5	2.8	9.6	1.3	0.3	0.5	-2.0	-3.1	-0.3	2.1
Prospective memory result	3.0	3.7	9.8	1.4	3.1	1.2	1.3	-2.4	1.4	1.8
Lung cancer (father)	1.4	1.6	4.7	2.2	1.7	-0.2	1.6	-0.3	0.8	-0.3
Illnesses of mother	1.1	1.3	4.3	0.9	-0.9	-1.3	0.5	1.2	2.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	4.3	-2.1	-1.7	0.6	1.0	1.2	0.1	-1.9
Pulse wave Arterial Stiffness index	1.8	2.1	7.0	-0.4	2.6	0.5	1.6	-1.2	1.6	0.8
Impedance of arm (left)	0.5	2.4	5.5	-0.5	-2.3	-1.1	-0.0	1.5	-2.3	-1.3
Arm fat mass (right)	2.3	9.6	17.7	2.5	3.7	0.2	2.5	-2.4	4.2	4.2
Trunk predicted mass	0.2	1.4	5.0	-0.3	1.6	-0.2	1.3	-0.4	2.2	0.0
Standing height	0.4	4.1	11.3	-2.6	-1.6	-1.0	1.8	2.0	0.3	-3.4
Length of working week for main job	0.4	0.5	1.5	0.4	0.1	-1.2	0.1	-0.6	0.9	-0.6
Exposure to tobacco smoke at home	1.4	1.5	4.0	-1.5	2.0	1.2	1.5	0.2	0.5	-0.7
Breastfed as a baby	1.4	1.8	9.4	0.1	0.3	-0.5	0.1	-0.7	3.1	-1.5
Tense / ‘highly strung’	1.1	1.9	5.3	-0.7	-1.0	-0.7	0.2	2.3	-1.1	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.1	0.0	-1.0	-0.1	1.5	1.7	-0.5	-1.5
Hair/balding pattern: Pattern 4	0.6	1.5	5.3	2.3	0.2	0.3	-0.3	-2.2	-0.4	-0.4
Birth weight of first child	1.2	2.1	8.4	-0.8	-0.8	-0.6	-0.0	2.9	-0.5	-2.2
Peak expiratory flow (PEF)	0.7	1.7	7.9	-0.8	0.2	0.6	1.7	0.0	2.8	-0.3
Pulse wave reflection index	0.1	0.1	0.4	-0.5	0.3	-0.3	-0.2	0.0	-0.0	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	-0.7	0.7	-0.7	0.9	-0.1	1.2	-0.8
Loud music exposure frequency	1.4	1.5	4.2	0.1	1.4	1.1	2.0	-0.1	1.6	0.7
Qualifications: O levels/GCSEs or equivalent	3.5	5.5	14.4	-3.6	-1.3	-0.6	1.7	2.4	0.7	-3.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.3	10.4	0.9	1.8	0.2	1.1	0.4	3.2	0.2
Blood clot in the leg (DVT)	2.1	2.7	7.8	0.2	1.9	0.1	2.3	-0.9	2.8	0.9
Medication: Paracetamol	1.1	1.8	5.1	2.2	-0.6	1.2	-0.9	-1.4	-0.4	1.8
Headache pain in last month	0.8	1.4	4.3	0.8	0.9	1.4	0.0	-0.5	1.5	2.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	0.3	-0.8	0.5	-0.4	-0.9	0.7	-0.8
Glaucoma (self-reported)	1.2	1.4	4.1	0.7	0.1	-0.1	-2.0	-1.9	-1.3	0.2
Gout (self-reported)	1.4	1.9	5.5	1.2	0.6	0.9	0.4	-2.0	-1.0	2.3
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	11.1	2.7	1.0	0.8	-0.6	-2.6	-0.0	3.3
Medication: Amlodipine	0.2	0.3	1.0	-0.2	0.8	-1.0	-0.8	-0.4	0.3	-0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.0	0.1	0.8	0.9	1.2	-0.1	1.4	0.8
Birth weight	0.5	1.1	2.2	0.6	0.8	-1.2	1.5	0.9	1.5	0.1
Chronic bronchitis/emphysema (mother)	2.1	2.4	5.3	2.0	2.3	1.0	1.1	-1.8	0.1	1.5
High blood pressure (siblings)	0.5	0.7	2.1	-1.4	-0.1	0.1	0.3	1.0	0.6	-1.0
Forced vital capacity (FVC), Best measure	0.9	3.3	7.0	-2.2	-1.3	1.2	2.0	2.0	0.0	-2.6
Body fat percentage	2.9	11.4	22.8	2.6	3.4	0.5	3.6	-2.2	4.6	4.8
Leg fat percentage (right)	3.2	11.7	23.8	2.5	3.5	1.1	3.7	-2.1	4.5	4.9
Arm fat-free mass (right)	0.4	2.1	8.8	-0.3	1.7	0.1	1.6	-0.6	3.0	0.5
Exposure to tobacco smoke outside home	1.3	1.7	4.3	0.4	1.7	1.0	0.0	-2.1	0.2	1.9
Comparative body size at age 10	0.1	0.3	1.1	0.5	0.2	-0.3	-1.0	0.6	0.1	0.4
Number of full brothers	0.8	0.9	3.4	0.6	1.0	1.8	1.2	-0.1	0.1	0.5
Worry too long after embarrassment	1.0	1.7	4.3	1.6	-0.0	0.3	1.6	2.1	1.5	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.8	0.8	1.0	-0.5	1.7	1.9	-0.7	-0.7
Wheeze or whistling in the chest in last year	0.8	1.4	4.3	0.7	1.0	2.1	0.8	-0.3	1.0	1.4
Number of children fathered	0.3	0.3	1.0	-0.6	-0.2	-0.6	0.4	-0.2	1.0	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.5	1.4	-0.2	0.0	0.7	1.0	-2.1	0.1
Age at first live birth	0.8	1.4	3.9	-1.7	-2.0	-0.5	-0.7	0.6	-0.8	-1.1
Pulse wave peak to peak time	1.8	2.2	8.0	0.2	-2.8	-0.6	-1.3	1.3	-1.5	-1.0
Health satisfaction	0.6	0.8	4.8	0.2	0.0	0.3	0.2	-2.2	-0.0	0.7
Shortness of breath walking on level ground	0.8	1.0	2.1	1.0	1.5	0.0	0.4	-1.4	0.4	1.3
Qualifications: College or University degree	2.2	7.0	19.8	-2.8	-2.5	-1.8	-1.5	1.8	-2.4	-4.5
Eye problems/disorders: None of the above	0.3	0.3	1.3	-0.3	0.0	-1.1	0.7	-0.2	0.4	-0.5
Mouth/teeth dental problems: Loose teeth	1.2	1.4	6.0	0.1	2.5	0.5	0.8	-0.4	1.5	1.0
Emphysema/chronic bronchitis	0.3	0.4	1.2	-0.2	0.6	-1.0	-0.1	-0.1	1.1	-0.4
Medication for pain relief, constipation, heartburn	1.5	2.5	5.0	-1.4	-1.4	-2.1	0.3	1.8	1.0	-2.2
Neck or shoulder pain in last month	0.6	0.8	2.5	1.6	-0.6	-0.0	0.8	-0.1	1.3	0.6
Medication: Blood pressure	0.5	0.9	2.4	-0.5	-0.2	-1.6	0.1	1.2	-1.5	0.5
Angina (self-reported)	0.7	1.0	2.0	-1.3	-0.0	-0.1	-1.1	-1.4	-1.4	-0.0
Migraine (self-reported)	0.3	0.4	1.5	-0.5	-0.4	1.2	0.1	0.2	0.6	-0.2
Medication: Ibuprofen	0.8	1.0	2.8	-1.1	-0.4	0.3	0.2	1.7	-1.5	-0.7
Medication: Allopurinol	2.0	2.6	7.3	0.8	1.3	1.4	-0.1	-2.3	-1.2	2.7
Medication: Omeprazole	2.6	3.1	8.8	1.9	3.0	1.3	1.1	-1.2	1.8	1.2
Medication: Seretide 50 evohaler	0.7	0.8	5.0	-0.1	-0.1	2.2	0.0	-0.8	0.3	-0.0
Mean time to correctly identify matches	0.4	0.8	4.0	0.7	0.2	-0.2	-0.2	-0.5	2.0	1.0
Heart disease (mother)	1.3	1.6	3.2	-0.2	1.8	1.6	-0.5	-1.8	0.4	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.0	0.8	-0.2	-0.8	-0.6	-1.4	0.3	0.7
Whole body fat mass	2.5	10.4	22.1	2.1	3.5	0.3	3.3	-2.2	4.7	4.2
Leg fat mass (right)	2.7	10.4	19.4	2.3	3.5	0.7	3.5	-2.0	4.4	4.3
Arm predicted mass (right)	0.5	2.5	9.6	-0.2	1.8	0.1	1.9	-0.8	3.1	0.6
Pulse rate, automated reading	0.3	1.0	3.1	-0.9	-0.1	1.8	-1.1	-1.1	0.3	0.9
Alcohol intake frequency.	0.2	0.5	2.2	-0.5	1.5	0.9	-0.4	-0.0	-0.3	-0.1
Comparative height size at age 10	0.2	1.4	3.6	-0.8	-0.5	0.5	1.9	1.6	0.5	-1.5
Number of full sisters	1.3	1.6	3.2	1.6	-1.3	0.9	-1.3	-0.3	-1.8	0.9
Suffer from ‘nerves’	0.4	0.6	2.1	1.5	0.5	-0.3	0.1	1.2	0.2	-0.7
Overall health rating	1.5	3.3	8.6	2.8	0.3	0.5	0.0	-2.5	0.7	2.9
Chest pain or discomfort	0.3	0.4	0.7	0.7	0.6	0.5	0.1	0.8	-0.8	-0.3
Had major operations	0.4	0.5	1.4	0.8	0.1	1.2	-0.5	0.4	-0.8	0.1
Age at last live birth	2.0	2.9	6.7	-2.6	-2.3	-0.5	-1.0	1.7	-1.1	-1.7
Family relationship satisfaction	1.2	1.5	5.9	0.6	-0.5	-1.1	0.7	2.4	0.1	-1.5
Leg pain on walking	0.8	1.0	3.0	0.6	0.6	0.9	1.0	-1.7	0.1	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.8	0.3	1.3	0.8	1.3	0.2	0.1	1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.5	0.6	-0.8	-0.0	-0.1	0.0	-1.0	1.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.3	1.7	1.8	0.2	-0.0	-1.1	1.7	0.8
Medication: Aspirin	0.7	1.0	2.2	-0.1	1.5	1.3	-0.3	-1.1	-1.1	0.3
Supplements: Vitamin C	0.2	0.2	0.9	0.4	-0.3	1.0	-0.3	-0.2	-0.4	0.4
Knee pain experienced in last month	1.9	2.9	5.9	2.4	2.1	1.8	0.9	-1.7	0.5	1.6
Hypertension (Self-reported)	0.4	1.0	4.0	-0.3	0.5	-2.0	-0.3	1.1	-1.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	5.8	1.7	0.3	1.0	-1.3	-2.4	-0.2	2.0
Illnesses of father: Heart disease	1.3	1.8	6.9	-2.6	-0.2	0.9	0.8	0.5	1.8	-0.7
Illnesses of siblings: Diabetes	0.6	0.7	2.8	0.1	-0.8	-0.4	-0.9	0.8	-1.7	0.2
Smoking status: Previous	0.5	0.7	1.9	1.1	0.3	-0.7	1.4	0.9	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.0	-1.4	-1.1	-1.0	0.6	1.0	-1.0	-1.4
Whole body fat-free mass	0.3	1.6	6.2	-0.1	1.7	-0.4	1.1	-0.8	2.5	0.3
Leg fat-free mass (right)	0.3	1.6	6.0	0.1	1.8	-0.4	0.4	-1.1	2.4	0.5
Arm fat percentage (left)	2.7	10.8	25.2	3.1	3.5	0.2	2.4	-2.5	4.0	5.0
Average weekly red wine intake	0.9	1.4	4.4	-0.2	-1.3	0.5	-0.2	2.1	-1.3	-1.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.4	1.1	0.2	1.6	-0.6	0.4	-1.8	0.8
Mood swings	0.8	1.5	3.9	1.6	-1.0	-1.0	0.6	2.0	-1.0	-1.0
Loneliness, isolation	1.3	1.8	7.4	1.0	1.0	0.7	0.7	2.7	-1.5	-0.3
Long-standing illness, disability or infirmity	0.4	0.6	2.9	0.6	0.1	0.6	-0.1	-1.7	0.2	0.9
Ever had bowel cancer screening	0.5	0.6	1.7	-0.4	-0.6	-0.7	-0.8	-0.5	1.3	0.5
Diabetes diagnosed by doctor	1.8	2.9	5.7	1.5	2.3	0.9	0.6	-2.4	-1.1	2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	3.7	-0.8	-0.0	0.1	0.5	1.9	0.1	-1.2
Friendships satisfaction	1.1	1.4	4.1	-0.4	-1.3	-1.0	-0.8	2.0	-0.3	-1.4
Qualifications: nursing, teaching	1.8	2.7	9.5	-2.3	-0.3	-0.6	0.7	1.4	-1.3	-3.1
Commuting to job workplace: Walk	0.5	0.6	1.9	0.0	0.3	-1.0	0.5	-0.9	1.4	-0.0
Eye problems/disorders: Cataract	0.3	0.4	1.4	-0.6	-1.2	0.4	-0.6	0.0	0.2	0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.0	-0.9	-0.7	-1.2	-0.2	0.4	0.1	-1.4
Medication for cholesterol	0.5	0.8	2.9	-0.5	-0.9	-0.0	1.7	0.8	0.9	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	4.6	-0.3	0.1	2.1	-0.7	-1.3	-0.3	0.9
Back pain experienced in last month	0.5	0.7	3.5	0.2	-0.3	-0.8	-0.3	-0.3	1.9	-0.4
Mineral and other dietary supplements	1.3	1.7	4.5	-1.3	2.1	0.1	1.3	1.3	1.2	-0.8
Breast cancer (self-reported)	0.1	0.1	0.2	-0.1	0.3	0.1	0.5	-0.4	-0.5	-0.1
Asthma (self-reported)	0.8	1.6	5.2	1.4	-0.1	2.3	1.3	-0.5	1.4	0.3
Osteoporosis (self-reported)	0.4	0.5	2.1	-0.5	0.1	-0.1	-1.4	-0.6	-0.8	-0.5
Osteoarthritis (self-reported)	1.1	1.5	7.1	0.7	0.8	0.1	0.1	-1.3	2.7	0.7
Medication: Aspirin	0.8	1.1	2.3	-0.4	1.5	1.5	-0.2	-1.4	-0.9	0.3
Medication: Gliclazide	1.5	1.7	4.3	1.5	0.8	-0.3	-1.3	-2.1	-0.5	1.6
Illnesses of father: None of the above (group 1)	1.6	2.0	8.4	1.1	-2.9	-1.9	-0.1	0.2	0.4	-0.7
Smoking status: Current	0.5	0.8	2.6	-0.1	-0.5	-0.3	-0.7	-1.6	-1.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.0	-0.0	-1.4	1.0	-2.0	-0.9	-1.3	0.8
Whole body water mass	0.3	1.7	6.5	-0.1	1.8	-0.4	1.2	-0.9	2.5	0.3
Leg predicted mass (right)	0.3	1.6	6.2	0.1	1.9	-0.4	0.3	-1.1	2.5	0.5
Arm fat mass (left)	2.3	9.6	18.1	2.5	3.5	0.2	2.6	-2.3	4.3	4.2
Number of self-reported non-cancer illnesses	0.9	1.6	3.7	1.6	1.6	0.2	-0.3	-1.9	-0.2	1.4
Average weekly champagne plus white wine intake	0.6	0.8	2.1	1.5	0.2	0.5	-0.4	-0.3	-1.1	1.2
Miserableness	0.8	1.4	6.1	1.3	0.2	-0.9	1.1	2.5	0.4	0.1
Guilty feelings	1.2	1.8	6.9	-0.1	1.1	1.3	2.6	1.6	0.6	-0.4
Wears glasses or contact lenses	0.5	0.5	2.8	-0.1	-1.7	0.2	-0.3	0.8	0.1	-0.3
Ever taken oral contraceptive pill	2.7	3.0	6.4	-2.5	-1.3	-0.6	1.9	1.6	-0.0	-2.5
Hearing aid user	1.4	1.6	6.5	-1.2	-0.5	0.3	1.2	-0.6	2.5	-1.1
Mother’s age at death	1.7	2.2	4.8	-1.1	-1.7	-1.7	-0.5	1.5	-0.8	-2.2
Financial situation satisfaction	0.3	0.4	0.7	-0.1	0.7	0.6	0.9	-0.7	0.6	0.5
Tinnitus: Yes, now most or all of the time	2.0	2.3	12.8	-0.4	0.9	-0.2	1.5	-0.3	3.6	-0.4
Commuting to job workplace: Public transport	0.4	0.5	1.7	0.2	0.4	-0.0	-1.3	0.8	-0.2	-0.8
Eye problems/disorders: Glaucoma	1.7	2.0	6.1	1.3	0.6	-0.2	-2.5	-1.9	-1.0	0.9
Medication: Blood pressure	0.4	0.8	2.5	1.0	0.4	-0.6	-1.2	0.1	-1.6	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	-0.3	0.1	0.8	-1.1	-0.8	-0.0	-0.6
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.9	1.5	-1.6	-0.3	-1.1	-2.2	-0.4	1.5
High cholesterol (Self-reported)	0.4	0.6	1.8	-0.6	-0.3	-1.0	-1.4	-1.0	-0.0	-0.3
Medication: Bendroflumethiazide	0.8	1.2	3.0	-0.4	-1.1	0.7	-0.9	1.5	-1.7	0.6
Medication: Paracetamol	0.6	0.9	1.6	1.2	-1.3	0.7	-0.8	-1.1	-1.0	0.7
Medication: Lisinopril	1.1	1.4	3.4	-1.7	-0.1	-0.3	0.1	0.3	-1.8	-1.8
Medication: Atorvastatin	0.7	0.8	2.7	-1.0	0.8	1.6	0.6	0.3	-0.1	0.9
Illnesses of father: High blood pressure	0.5	0.6	2.9	-0.9	0.5	1.7	0.4	-0.2	-0.1	-0.2
Alcohol drinker status: Never	0.7	0.8	2.9	-0.7	-1.0	-0.6	-1.1	-0.0	-1.7	-0.2
Ever smoked	0.3	0.5	1.5	1.2	0.0	-0.6	1.0	-0.1	-0.8	-0.0
Basal metabolic rate	0.5	2.5	8.2	0.4	2.1	-0.3	1.6	-1.1	2.9	1.0
Leg fat percentage (left)	2.8	10.2	21.3	2.1	3.2	1.0	3.6	-1.8	4.6	4.2
Arm fat-free mass (left)	0.5	2.8	8.8	0.0	2.2	0.2	2.1	-0.8	3.0	0.6
Number of operations (self-reported)	1.5	2.3	11.0	0.3	0.7	3.3	-1.3	-1.1	-0.9	0.8
Average weekly beer plus cider intake	2.6	3.8	15.4	1.2	3.9	-0.3	1.3	0.3	2.1	1.8
Irritability	0.7	1.2	3.5	-0.3	-0.5	-0.2	1.1	1.9	-0.5	-1.8
Risk taking	2.3	3.3	10.4	-2.1	0.7	1.7	3.2	1.2	1.8	-0.6
Ever had prostate specific antigen (PSA) test	0.7	0.9	2.7	-0.8	-1.3	0.3	-0.7	0.4	-1.6	0.3
Fractured/broken bones in last 5 years	1.3	1.7	3.4	0.6	1.0	1.2	1.9	0.2	1.6	1.8
Age started oral contraceptive pill	0.3	0.3	0.7	0.7	-0.4	-0.2	-0.4	-0.7	-0.9	-0.4
Diastolic blood pressure, automated reading	0.2	0.6	1.0	-0.9	1.0	-1.0	0.8	0.3	0.9	0.4
Ever depressed for a whole week	0.4	0.5	1.7	1.3	0.0	0.4	0.3	0.0	-1.1	0.3
Unable to work because of sickness or disability	1.2	1.5	6.0	0.4	0.8	-0.3	-0.0	-2.4	1.1	1.5
Commuting to job workplace: Cycle	0.7	0.9	2.4	-0.5	1.6	0.7	0.7	-0.7	1.2	-0.7
Myopia	6.9	9.9	16.6	-2.6	-4.1	-1.7	-3.4	3.9	-3.4	-2.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.2	-0.3	-1.1	1.3	0.7	0.3	1.0	-1.5
Cholesterol lowering medication	0.9	1.3	3.0	-0.6	0.3	1.1	-1.7	-1.7	-1.2	0.3
Medication: Omeprazole (e.g. Zanprol)	4.0	4.9	8.5	2.4	2.9	2.0	1.3	-1.9	2.5	2.1
Pain experienced in last month	1.3	2.2	7.1	-2.7	-0.9	-1.4	-0.6	0.7	-0.7	-1.9
Supplements: Calcium	0.2	0.3	0.9	-0.2	0.3	0.6	-0.3	0.5	0.2	-0.9
Basal cell carcinoma (self-reported)	2.4	2.8	7.6	-1.4	-2.5	0.1	-2.8	-0.5	-0.6	-1.9
Heart attack/myocardial infarction (self-reported)	1.1	1.4	6.5	-0.4	0.4	0.3	-2.5	-1.1	-1.3	0.3
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	8.2	0.3	1.7	0.1	2.1	-0.9	2.9	0.8
Heart disease (siblings)	2.0	2.4	6.5	1.9	2.0	0.8	-0.1	-0.8	1.3	2.5
Alcohol drinker status: Previous	1.1	1.2	5.6	0.6	-0.5	-1.0	-2.4	-0.8	-0.2	0.9
Pack years of smoking	0.4	0.5	2.1	-0.5	1.5	-0.2	-0.3	-0.7	0.6	-0.7
Impedance of whole body	0.5	2.7	6.3	-1.0	-2.5	-0.6	1.2	1.9	-1.8	-1.7
Leg fat mass (left)	2.4	9.3	20.2	2.0	3.4	0.5	3.4	-1.9	4.5	3.8
Arm predicted mass (left)	0.6	3.1	9.2	-0.1	2.4	0.5	2.2	-1.1	3.0	0.5