TWAS hub - AP1M2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0911	0.0363	2.5e-03	0.008	0.006	0.033	0.017	0.034	0.02600	5.2e-02	3.8e-05	0.0023	3.3e-05
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.2549	0.0777	6.8e-08	0.033	0.068	0.079	NA	0.081	0.00011	4.5e-08	3.4e-09	NA	1.8e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Alcohol drinker status: Never	6.5	7.8	15.5	3.9	-0.2
Medication: Co-codamol	5.1	5.9	10.8	-1.0	-3.3
Forced expiratory volume in 1-second (FEV1), predicted	5.1	10.5	18.7	4.3	-1.5
Stomach or abdominal pain in last month	5.0	6.2	12.5	-0.1	-3.5
Emphysema/chronic bronchitis	4.8	5.4	6.8	-2.6	2.0
Rheumatoid Arthritis	4.4	6.0	11.2	0.9	3.3
Hayfever, allergic rhinitis or eczema	4.3	9.3	15.9	-1.7	4.0
Allergy	4.1	9.4	11.4	2.7	-3.4
Lupus	3.9	5.9	11.7	0.4	3.4
Ever used hormone-replacement therapy (HRT)	3.9	5.0	7.9	-2.8	1.4
Ever highly irritable/argumentative for 2 days	3.9	4.6	8.6	-0.8	-2.9
Medication: Omeprazole (e.g. Zanprol)	3.8	4.6	6.8	2.6	-1.6
Knee pain experienced in last month	3.5	5.4	9.3	3.0	-1.2
Medication: Omeprazole	3.2	3.8	5.3	2.3	-1.5
Hearing difficulty/problems with background noise	3.0	4.8	6.3	2.5	-1.8
Arm predicted mass (left)	3.0	15.5	24.8	5.0	-2.5
Chronotype (morning person)	2.9	6.8	7.9	-2.4	2.8
Bilateral oophorectomy (both ovaries removed)	2.9	3.3	3.6	-1.9	1.7
Arm fat-free mass (left)	2.9	14.7	23.0	4.8	-2.5
Hip circumference	2.8	11.9	14.4	3.8	-3.0
Trunk predicted mass	2.8	16.0	28.3	5.3	-1.9
Arm predicted mass (right)	2.8	14.1	23.5	4.8	-2.2
Trunk fat-free mass	2.7	15.5	27.2	5.2	-1.9
Blood clot in the leg (DVT)	2.7	3.5	5.5	-2.3	1.2
Arm fat-free mass (right)	2.7	13.9	23.1	4.8	-2.2
Number of children fathered	2.6	2.9	5.8	-2.4	-0.2
Whole body fat-free mass	2.6	14.7	26.2	5.1	-1.8
Whole body water mass	2.5	14.1	25.1	5.0	-1.7
Basal metabolic rate	2.5	13.7	23.9	4.9	-1.9
Fractured/broken bones in last 5 years	2.5	3.2	6.4	0.1	-2.5
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.8	6.6	-1.0	-2.6
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	4.4	-2.1	1.2
Comparative height size at age 10	2.3	12.9	25.6	5.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	6.9	0.2	-2.6
Depression (self-reported)	2.2	2.6	5.2	0.0	-2.3
Height	2.1	40.1	79.7	8.9	-0.6
Age at last live birth	2.1	3.1	6.2	-0.2	-2.5
Long-standing illness, disability or infirmity	2.1	3.2	4.6	1.3	2.1
Leg fat-free mass (left)	2.0	10.5	18.6	4.3	-1.5
Qualifications: CSEs or equivalent	2.0	2.6	4.9	2.2	-0.6
Leg fat-free mass (right)	2.0	10.8	20.5	4.5	-1.0
Leg predicted mass (right)	2.0	10.8	20.5	4.5	-1.0
Worry (Nagel 2018)	1.9	4.0	5.2	-1.7	2.3
Primary Biliary Cirrhosis	1.9	2.7	3.2	1.8	-1.5
Medication for hormone replacement therapy	1.9	2.1	4.0	-2.0	0.4
Leg predicted mass (left)	1.9	10.1	18.0	4.2	-1.5
Illnesses of siblings	1.9	2.7	3.2	1.5	-1.8
Weight	1.9	9.5	16.2	4.0	-1.7
Standing height	1.9	18.5	37.0	6.1	0.0
Friendships satisfaction	1.9	2.3	3.5	1.1	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	4.5	-2.1	0.7
HDL Cholesterol	1.8	3.1	3.7	1.9	-1.6
Financial difficulties in last 2 years	1.8	2.5	2.7	1.6	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	4.1	-2.0	0.5
Leg pain on walking	1.8	2.3	4.5	0.0	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	5.6	-0.2	-2.4
Medication: Gliclazide	1.8	2.1	3.4	0.9	-1.8
Guilty feelings	1.8	2.6	5.2	-2.3	-0.3
Sitting height	1.7	12.0	24.0	4.9	-0.1
Neck or shoulder pain in last month	1.7	2.4	3.2	1.3	-1.8
Osteoporosis (self-reported)	1.7	2.0	3.7	-0.6	1.9
Osteoarthritis (self-reported)	1.7	2.1	4.2	2.1	-0.3
Heart disease (siblings)	1.7	2.0	4.0	-2.0	0.2
Alzheimer’s Disease (in father)	1.6	1.8	3.5	-0.3	-1.9
Waist Hip Ratio (WHR)	1.6	7.3	8.1	-2.6	2.8
Allergy or Eczema	1.6	4.2	7.1	-1.1	2.7
Pack years adult smoking proportion	1.6	2.5	5.0	-2.2	-0.0
Relative age voice broke	1.6	2.5	2.6	-1.6	1.6
Pulse rate	1.6	2.8	4.4	-2.1	1.1
Handedness (chirality/laterality): Left-handed	1.6	2.0	3.5	-1.9	0.6
Supplements: Fish oil (including cod liver oil)	1.6	2.0	2.2	1.4	1.5
Medication: Atorvastatin	1.6	2.0	4.0	-2.0	0.1
Commuting to job workplace: Cycle	1.6	2.0	3.9	-0.1	-2.0
Cholesterol lowering medication	1.6	2.3	4.4	0.5	-2.1
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	3.7	1.9	0.4
High blood pressure (mother)	1.5	2.1	3.6	0.8	-1.9
Falls in the last year	1.5	2.0	4.0	-0.2	-2.0
Qualifications: College or University degree	1.5	4.7	6.4	-1.7	2.5
Supplements: Vitamin C	1.5	1.7	2.0	-1.4	-1.2
Mineral and other dietary supplements	1.5	2.0	3.7	-0.6	-1.9
Hair/balding pattern: Pattern 2	1.4	1.8	2.7	-1.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.1	1.8	-0.3
Supplements: Calcium	1.4	1.5	2.8	-0.5	1.7
Neuroticism (Nagel 2018)	1.3	3.1	4.8	-2.2	1.2
Type 2 Diabetes (T2D) (2018)	1.3	2.4	3.3	1.2	-1.8
Diabetes (father)	1.3	1.6	1.9	1.4	1.1
Maternal smoking around birth	1.3	2.0	3.2	-1.8	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	4.9	1.8	-2.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	2.3	1.4	-1.5
Chest pain or discomfort	1.3	1.8	2.7	1.6	-1.0
Illnesses of father: Heart disease	1.3	1.8	3.5	-1.9	-0.2
Diabetes diagnosed by doctor	1.3	2.1	3.1	1.8	-1.1
Medication: Atenolol	1.2	1.5	2.2	-0.9	1.5
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.9	0.0	-1.7
Worrier / anxious feelings	1.2	2.3	2.7	-1.4	1.6
Noisy workplace	1.2	1.5	2.0	1.0	-1.4
Lung cancer (father)	1.2	1.4	1.8	-1.4	0.9
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	1.6	-1.2	1.2
Forced vital capacity (FVC), Best measure	1.2	4.2	4.3	2.0	-2.1
Alcohol intake frequency.	1.2	2.7	4.6	2.1	0.9
Family relationship satisfaction	1.2	1.5	2.9	-0.2	-1.7
Ever had bowel cancer screening	1.2	1.4	2.5	0.6	1.6
Arm fat mass (left)	1.2	4.8	7.0	2.6	-1.6
Ever taken oral contraceptive pill	1.2	1.4	2.2	-1.5	-0.7
Tinnitus: Yes, now most or all of the time	1.2	1.3	2.4	1.6	0.5
Blood Platelet Count	1.1	13.0	20.4	4.5	2.3
Lung FEV1/FVC ratio	1.1	5.3	8.6	1.4	-2.9
Hearing difficulty/problems: Yes	1.1	1.7	3.1	1.8	-0.6
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.1	1.5	-0.7
Trunk fat mass	1.1	4.7	7.6	2.8	-1.3
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	4.9	1.7	-2.2
Worry too long after embarrassment	1.1	1.9	3.2	-1.8	0.7
Heart disease (mother)	1.1	1.3	1.8	0.9	-1.3
Whole body fat mass	1.1	4.4	6.0	2.4	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.4	1.1	-1.2
Loneliness, isolation	1.1	1.5	3.0	-0.0	-1.7
Irritability	1.1	1.8	3.0	-1.7	0.8
Pack years of smoking	1.1	1.6	3.1	-1.8	-0.3
Verbal and Numeric Reasoning (VNR)	1.0	2.5	4.8	0.5	2.2
HbA1C	1.0	1.1	1.2	-1.0	-1.1
Pulse wave reflection index	1.0	1.2	1.3	1.1	-1.1
Eye problems/disorders: None of the above	1.0	1.1	2.2	-1.5	0.3
Leg fat mass (right)	1.0	3.8	4.9	1.6	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.6	-0.7	-1.3
Eye problems/disorders: Cataract	1.0	1.1	1.6	0.8	1.3
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.9	0.6	1.4
Bipolar Disorder (2018)	0.9	1.5	2.9	-1.7	-0.2
Breast Cancer	0.9	2.1	4.1	-2.0	0.3
Schizophrenia (2014)	0.9	1.9	3.3	-0.7	-1.8
Triglycerides	0.9	1.4	1.9	1.0	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	2.3	-0.5	-1.5
Taking other prescription medications	0.9	1.3	2.7	1.6	0.1
Age when periods started (menarche)	0.9	2.1	2.6	-1.6	-1.2
Medication: Simvastatin	0.9	1.3	2.1	-1.5	0.7
Fluid intelligence score	0.9	1.8	2.9	-0.9	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.6	-0.8	-1.3
Arm fat mass (right)	0.9	3.9	5.7	2.4	-1.5
Length of working week for main job	0.9	1.0	1.3	-0.8	-1.1
Number of full sisters	0.9	1.2	2.2	0.4	1.5
Mood swings	0.9	1.6	3.3	-1.8	-0.1
Number of self-reported non-cancer illnesses	0.9	1.5	2.8	0.4	1.7
Myopia	0.9	1.3	1.4	-1.1	1.2
Leg fat mass (left)	0.9	3.5	3.6	1.8	-1.9
Bipolar Disorder or Schizophrenia	0.8	1.9	2.4	-1.5	-1.2
Number of incorrect matches in round	0.8	1.3	2.5	-0.4	1.6
Medication: Cholesterol lowering	0.8	1.2	1.9	-1.4	0.8
Tense / ‘highly strung’	0.8	1.4	2.6	-1.6	0.4
Wheeze or whistling in the chest in last year	0.8	1.5	2.3	1.5	-0.8
Medication: Ibuprofen	0.8	0.9	1.7	-1.3	-0.3
Medication: Seretide 50 evohaler	0.8	1.0	1.9	0.1	-1.4
Schizophrenia vs Biploar Disorder	0.7	0.9	1.2	1.1	0.8
Alzheimer’s Disease (in mother)	0.7	0.8	0.8	-0.9	0.9
Body Mass Index (BMI) (2010)	0.7	0.9	1.4	-0.7	1.2
Sensitivity / hurt feelings	0.7	1.1	1.8	-1.4	-0.6
Ever had hysterectomy (womb removed)	0.7	0.8	1.2	-1.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.1	-1.0	1.4
Waist circumference	0.7	2.5	3.6	1.9	-1.1
Had menopause	0.7	0.9	1.6	-0.5	1.3
Forced vital capacity (FVC)	0.7	2.8	4.4	1.1	-2.1
Impedance of arm (right)	0.7	3.5	5.9	-1.0	2.4
Peak expiratory flow (PEF)	0.7	1.5	2.6	1.6	-0.7
High blood pressure (siblings)	0.7	1.0	1.3	-0.9	1.1
Leg fat percentage (right)	0.7	2.4	4.7	0.0	-2.2
Mean time to correctly identify matches	0.7	1.3	2.0	-0.8	1.4
Illnesses of siblings: Diabetes	0.7	0.9	1.3	-0.7	1.2
Average weekly red wine intake	0.7	1.1	1.7	0.7	-1.3
Average weekly champagne plus white wine intake	0.7	1.0	1.8	-1.3	0.4
Miserableness	0.7	1.3	2.6	0.0	-1.6
Pain experienced in last month	0.7	1.1	2.2	-0.4	1.5
BMI	0.6	3.6	7.2	0.1	-2.7
Average weekly spirits intake	0.6	0.7	1.4	0.2	1.2
Relative age of first facial hair	0.6	1.2	1.3	-1.1	1.1
Serious illness, injury or assault to yourself	0.6	0.8	1.5	-0.1	-1.2
Chronic bronchitis/emphysema (father)	0.6	0.8	0.8	-0.9	-0.8
Body mass index (BMI)	0.6	2.3	2.8	1.4	-1.7
Nervous feelings	0.6	1.0	1.9	-1.4	0.4
Diabetes (self-reported)	0.6	0.9	1.6	1.3	-0.5
Impedance of arm (left)	0.6	2.7	5.0	-0.7	2.2
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.0	1.0	-1.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.3	0.1	1.5
Medication: Allopurinol	0.6	0.8	1.0	0.8	1.0
Illnesses of father: None of the above (group 1)	0.6	0.7	1.4	1.2	0.0
Financial situation satisfaction	0.6	0.7	1.0	0.7	-1.0
Schizophrenia (2018)	0.5	1.1	1.7	-0.7	-1.3
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	-1.2	0.1
Crohns Disease (2017)	0.5	1.2	2.2	0.3	1.5
Blood White Count	0.5	3.3	5.8	-1.0	-2.4
Average weekly fortified wine intake	0.5	0.6	0.6	-0.8	0.8
Supplements: Glucosamine	0.5	0.7	1.1	0.5	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.6	-0.7	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.5	-0.2	-1.2
Medication for pain relief, constipation, heartburn	0.5	0.9	1.8	-0.2	1.3
Overall health rating	0.5	1.0	1.8	0.6	-1.3
Commuting to job workplace: Walk	0.5	0.5	0.9	-1.0	0.3
Medication: Blood pressure	0.5	1.0	2.0	1.4	0.1
Alcohol drinker status: Previous	0.5	0.6	0.8	-0.6	0.9
Mean Putamen Volume	0.4	0.4	0.7	0.8	-0.4
Fasting Glucose	0.4	0.5	0.6	-0.7	-0.8
Neuroticism (2016)	0.4	0.6	0.8	-0.9	-0.6
Blood Eosinophil Count	0.4	2.9	3.6	1.9	1.5
Angina	0.4	0.5	0.9	0.2	-0.9
Current tobacco smoking	0.4	0.6	0.8	-0.9	-0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	0.5	0.8
Had other major operations	0.4	0.5	0.6	-0.7	-0.8
Neuroticism score	0.4	0.7	1.3	-1.1	0.4
Father’s age at death	0.4	0.5	0.8	0.5	0.9
Prospective memory result	0.4	0.4	0.5	-0.6	-0.7
Loud music exposure frequency	0.4	0.4	0.6	0.8	0.4
Body fat percentage	0.4	1.5	1.8	1.1	-1.3
Comparative body size at age 10	0.4	1.0	1.6	0.7	1.3
Shortness of breath walking on level ground	0.4	0.4	0.8	0.3	0.9
Medication: Blood pressure	0.4	0.7	1.3	-1.1	0.4
Angina (self-reported)	0.4	0.6	1.0	0.4	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.7	0.5	0.8
Back pain experienced in last month	0.4	0.6	1.0	-0.4	-1.0
Breast cancer (self-reported)	0.4	0.5	0.7	-0.5	0.8
Hearing aid user	0.4	0.5	0.7	0.8	-0.6
Mother’s age at death	0.4	0.5	0.9	1.0	-0.1
High cholesterol (Self-reported)	0.4	0.7	1.3	-1.1	-0.1
Leg fat percentage (left)	0.4	1.5	2.9	0.4	-1.7
Average weekly beer plus cider intake	0.4	0.5	0.5	-0.7	-0.7
Risk taking	0.4	0.6	0.8	-0.9	0.6
Ever depressed for a whole week	0.4	0.5	0.6	0.8	-0.6
Impedance of whole body	0.4	1.9	2.9	-0.9	1.7
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.5	-0.5	1.2
Reaction Time	0.3	0.6	0.6	-0.8	0.7
LDL Cholesterol	0.3	0.5	0.8	0.9	0.5
Heel T-Score	0.3	2.5	4.5	2.1	0.7
Cardiovascular Disease	0.3	0.9	1.4	1.2	0.5
Neuroticism	0.3	0.7	1.1	-1.1	0.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.8	0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.8	0.0
Trunk fat percentage	0.3	1.4	2.0	1.4	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.5	-0.7	0.5
Medication: Ramipril	0.3	0.4	0.9	-0.2	0.9
Arm fat percentage (right)	0.3	1.2	1.2	1.1	-1.1
Alcohol intake versus 10 years previously	0.3	0.4	0.7	0.1	-0.9
Breastfed as a baby	0.3	0.4	0.8	-0.9	-0.2
Headache pain in last month	0.3	0.4	0.4	0.7	0.7
Gout (self-reported)	0.3	0.3	0.7	0.8	0.2
Medication: Amlodipine	0.3	0.4	0.6	-0.5	0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.2	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.6	-0.4	-0.8
Age at first live birth	0.3	0.6	1.2	0.0	-1.1
Health satisfaction	0.3	0.4	0.7	-0.8	-0.2
Had major operations	0.3	0.3	0.3	0.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.3	-0.5	-0.6
Arm fat percentage (left)	0.3	1.3	1.6	1.3	-0.9
Smoking status: Current	0.3	0.5	0.8	-0.5	-0.9
Wears glasses or contact lenses	0.3	0.4	0.7	0.2	-0.8
Commuting to job workplace: Public transport	0.3	0.4	0.8	-0.1	-0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.5	0.7	-0.6
Illnesses of father: High blood pressure	0.3	0.4	0.7	0.2	0.8
Age started oral contraceptive pill	0.3	0.4	0.6	0.4	0.7
Irritable Bowel Disease (IBD)	0.2	0.6	1.1	-0.1	1.1
Prostate Cancer	0.2	0.3	0.5	0.2	0.7
Ulcerative Colitis	0.2	0.2	0.5	0.1	0.7
Hypothyroidism (self reported)	0.2	0.5	0.7	0.5	0.9
Respiratory disease	0.2	0.4	0.7	0.4	0.8
Systolic blood pressure, automated reading	0.2	0.7	1.4	-0.3	-1.2
Vitamin and mineral supplements	0.2	0.3	0.3	0.5	0.6
Impedance of leg (right)	0.2	1.1	2.2	-1.5	-0.2
Multivitamins +/- minerals	0.2	0.2	0.2	0.5	0.4
Impedance of leg (left)	0.2	0.8	1.3	-1.1	0.5
Mouth/teeth dental problems	0.2	0.2	0.5	0.2	0.7
Time employed in main current job	0.2	0.2	0.3	-0.5	-0.4
Number of live births	0.2	0.3	0.5	-0.3	-0.7
Happiness	0.2	0.3	0.5	0.7	0.2
Medication: Lansoprazole	0.2	0.2	0.4	0.2	0.7
Illnesses of mother	0.2	0.2	0.3	-0.5	0.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	0.5	-0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	0.4	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.2	0.4	-0.5
Medication for cholesterol	0.2	0.3	0.4	-0.7	0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	-0.3	0.7
Number of operations (self-reported)	0.2	0.4	0.5	-0.7	0.4
Unable to work because of sickness or disability	0.2	0.2	0.3	0.3	-0.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.6	-0.4
Depression (Nagel 2018)	0.1	0.2	0.4	-0.6	-0.1
Ovarian Cancer	0.1	0.1	0.1	-0.2	-0.4
Age at First Birth	0.1	0.2	0.3	0.6	0.3
Crohns Disease (2012)	0.1	0.2	0.3	0.5	0.2
Blood Red Count	0.1	1.4	2.8	0.1	-1.7
Smoking Status	0.1	0.2	0.4	0.2	-0.6
Lung FVC	0.1	0.5	1.0	-1.0	0.2
Hair Pigment	0.1	2.1	2.2	-1.5	1.4
Tanning	0.1	1.8	3.6	-0.1	-1.9
Number of treatments/medications taken	0.1	0.2	0.3	-0.2	0.6
Medication: Metformin	0.1	0.2	0.4	-0.2	-0.6
Diabetes (mother)	0.1	0.1	0.3	-0.1	-0.5
Hand grip strength (right)	0.1	0.3	0.5	0.7	-0.2
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.1	0.6
Heart attack	0.1	0.2	0.3	-0.3	-0.6
Pain all over the body in last month	0.1	0.1	0.1	-0.0	-0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	0.3	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	0.2	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.1	-0.3	-0.3
Exposure to tobacco smoke at home	0.1	0.2	0.2	0.3	-0.5
Hair/balding pattern: Pattern 4	0.1	0.4	0.7	-0.2	-0.8
Birth weight of first child	0.1	0.2	0.2	0.5	0.4
Medication: Paracetamol	0.1	0.1	0.2	-0.4	-0.4
Glaucoma (self-reported)	0.1	0.2	0.3	-0.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.1	-0.4
Pulse wave peak to peak time	0.1	0.1	0.1	-0.1	0.3
Migraine (self-reported)	0.1	0.1	0.2	0.1	0.5
Pulse rate, automated reading	0.1	0.2	0.3	-0.1	-0.6
Suffer from ‘nerves’	0.1	0.1	0.3	-0.2	0.5
Medication: Aspirin	0.1	0.1	0.1	0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.1	-0.7
Medication: Lisinopril	0.1	0.1	0.1	0.1	0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.3	0.6	-0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.2	-0.5
Ulcerative Colitis (UC)	0.0	0.1	0.1	-0.4	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.0	0.2	0.4	-0.7	-0.1
Hand grip strength (left)	0.0	0.0	0.1	0.0	0.2
Supplements: Zinc	0.0	0.0	0.1	0.2	0.3
Severe depression (siblings)	0.0	0.0	0.0	0.0	0.2
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.0	-0.1
Fed-up feelings	0.0	0.1	0.1	0.0	-0.3
High blood pressure	0.0	0.0	0.1	0.0	-0.3
Past tobacco smoking	0.0	0.1	0.1	-0.3	0.1
Alcohol usually taken with meals	0.0	0.1	0.1	-0.3	-0.1
Qualifications: None of the above	0.0	0.1	0.1	0.3	0.2
Asthma	0.0	0.0	0.0	0.2	0.2
Birth weight	0.0	0.0	0.0	-0.2	-0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.2	-0.1
Number of full brothers	0.0	0.0	0.1	-0.2	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.1	-0.2
Hypertension (Self-reported)	0.0	0.1	0.1	0.1	0.3
Smoking status: Previous	0.0	0.0	0.0	0.1	0.1
Qualifications: nursing, teaching	0.0	0.1	0.1	0.2	-0.2
Asthma (self-reported)	0.0	0.0	0.1	0.1	0.3
Medication: Aspirin	0.0	0.1	0.1	0.2	0.2
Medication: Bendroflumethiazide	0.0	0.0	0.0	0.0	-0.0
Medication: Paracetamol	0.0	0.0	0.1	-0.3	-0.1
Ever smoked	0.0	0.0	0.0	-0.2	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.0	0.1	-0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.1	-0.2

Hub : Genes

AP1M2

Models

Trait associations