Hub : Genes

AP5B1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.105	0.0361	3.7e-05	0.020	NA	0.074	NA	0.055	0.0097	NA	1.8e-06	NA	3.8e-05
2	GTEx	Esophagus Mucosa	0.068	0.0300	1.5e-03	-0.001	NA	0.000	NA	-0.004	0.4200	NA	2.9e-01	NA	9.3e-01
3	GTEx	Esophagus Muscularis	0.089	0.0440	1.0e-02	0.004	NA	0.019	NA	0.005	0.1700	NA	2.2e-02	NA	1.6e-01
4	GTEx	Ovary	0.395	0.1300	9.2e-03	-0.006	NA	-0.007	NA	0.002	0.4900	NA	5.2e-01	NA	2.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.2	1.8	3.8	1.3	0.9	1.9	-1.0
Bipolar Disorder or Schizophrenia	2.3	5.7	10.2	2.5	2.3	3.2	-0.9
Depressed Affect (Nagel 2018)	0.4	0.9	3.1	0.4	-0.5	0.5	1.8
Depression (Nagel 2018)	1.0	1.5	5.2	-0.2	0.5	0.7	2.3
Intelligence (Savage-Jansen 2018)	0.8	2.4	6.8	-0.9	-0.6	-1.2	2.6
Neuroticism (Nagel 2018)	0.7	1.7	3.2	0.8	-0.0	1.8	1.7
Schizophrenia (2018)	2.0	4.1	6.4	2.2	2.3	2.5	-0.3
Schizophrenia vs Biploar Disorder	0.7	1.0	2.4	0.2	1.5	-1.2	-0.2
Worry (Nagel 2018)	0.8	1.7	3.1	0.8	1.4	1.8	0.9
Alzheimer’s Disease (in mother)	1.2	1.4	2.2	-1.5	-1.1	-1.1	1.1
Alzheimer’s Disease (in father)	1.5	1.6	2.1	-0.9	-1.5	-1.2	-1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	-0.8	-0.8	-1.2	0.5
Crohns Disease (2017)	3.1	6.7	12.5	-2.6	2.4	-1.6	3.5
Irritable Bowel Disease (IBD)	2.5	5.9	13.2	-1.7	2.7	-0.3	3.6
Ulcerative Colitis (UC)	1.0	2.0	3.6	-0.2	1.9	0.8	1.9
Major Depression (MDD)	2.0	2.4	5.3	1.9	0.9	2.3	0.0
Reaction Time	4.6	8.7	11.7	3.3	3.1	3.4	-1.8
Verbal and Numeric Reasoning (VNR)	1.8	4.3	8.7	-2.2	0.3	-1.9	3.0
Breast Cancer	5.7	13.8	21.3	3.7	-4.6	3.4	-3.0
Ovarian Cancer	0.9	1.2	2.4	-0.5	-1.2	-0.9	1.6
Prostate Cancer	1.8	2.6	8.6	0.6	2.9	1.1	-0.4
Age at First Birth	0.2	0.3	0.6	0.1	0.7	0.4	0.7
Bipolar Disorder (2011)	1.2	1.1	2.2	-0.3	-0.7	1.3	1.5
Body Mass Index (BMI) (2010)	1.5	2.1	4.6	1.9	2.1	0.1	0.5
Coronary Artery Disease (CAD)	1.0	1.2	2.4	-1.1	-1.6	-0.8	0.6
Crohns Disease (2012)	1.8	2.9	5.9	-1.5	1.7	-0.6	2.4
Mean Putamen Volume	2.5	2.8	8.6	1.3	2.9	1.0	0.2
Fasting Glucose	0.4	0.5	1.2	1.1	0.3	0.0	0.9
HbA1C	0.2	0.2	0.6	0.8	-0.1	0.2	0.1
HDL Cholesterol	0.4	0.7	1.5	-0.9	-1.2	0.4	0.6
LDL Cholesterol	2.8	4.5	14.0	1.1	3.7	0.8	1.4
Lupus	0.4	0.7	1.9	0.0	1.4	-0.5	0.7
Neuroticism (2016)	0.2	0.3	0.6	-0.8	-0.7	-0.2	0.4
Primary Biliary Cirrhosis	0.3	0.5	1.5	0.4	1.2	0.4	-0.1
Rheumatoid Arthritis	1.0	1.3	3.1	-1.8	-0.6	-0.7	1.2
Schizophrenia (2014)	1.4	3.0	7.0	1.6	2.6	1.6	-0.1
Triglycerides	0.4	0.7	2.1	0.2	-0.6	-1.4	-0.5
Type 2 Diabetes (T2D) (2012)	2.0	2.3	5.2	1.7	2.3	0.9	-0.3
Ulcerative Colitis	1.0	1.5	3.9	-0.9	0.8	0.6	2.0
Blood Eosinophil Count	4.9	38.0	121.0	3.4	-11.0	4.3	-1.0
Blood Platelet Count	3.4	39.7	106.1	-6.3	-10.3	-3.0	2.0
Blood Red Count	0.5	5.1	14.8	-0.8	3.9	-0.6	2.1
Blood White Count	0.7	5.4	11.1	2.1	-2.5	3.3	-0.4
Heel T-Score	1.9	14.7	25.8	2.6	-5.1	1.1	5.0
BMI	0.9	5.0	11.2	-0.3	2.6	-1.5	3.4
Height	2.2	42.7	69.1	-8.3	-7.9	-6.0	2.0
Waist Hip Ratio (WHR)	0.8	3.5	6.9	2.6	-1.5	-0.9	-2.0
Systolic Blood Pressure	0.5	2.5	6.0	-1.5	0.2	-2.4	-1.2
Smoking Status	0.1	0.2	0.5	0.3	0.2	-0.7	0.6
Allergy or Eczema	6.5	17.0	25.0	5.0	-4.4	4.8	0.6
Cardiovascular Disease	0.2	0.5	1.1	-0.8	0.2	-1.1	0.6
Hypothyroidism (self reported)	0.9	2.1	4.2	0.7	-2.0	1.1	1.6
Respiratory disease	4.0	8.8	20.0	4.5	-1.3	3.0	2.1
Type 2 Diabetes (T2D) (2018)	1.8	3.4	11.3	3.4	0.8	1.2	-0.2
Lung FEV1/FVC ratio	1.0	5.0	15.8	-0.9	-0.3	-1.8	-4.0
Lung FVC	0.4	2.3	7.5	0.7	1.0	-0.1	2.7
Neuroticism	0.9	2.2	6.8	0.4	0.1	1.4	2.6
Chronotype (morning person)	0.7	1.7	3.0	1.3	-1.5	-0.2	-1.7
Hair Pigment	0.3	7.3	22.6	-4.8	-0.3	-1.1	2.3
Tanning	0.2	2.1	7.1	2.7	0.8	0.8	-0.1
Hand grip strength (left)	0.6	1.6	2.5	-1.6	-1.0	-0.8	1.5
Number of treatments/medications taken	0.6	1.0	3.3	-0.4	-1.8	-0.4	0.6
Average weekly spirits intake	0.4	0.5	1.3	-0.6	1.1	-0.4	-0.3
Sensitivity / hurt feelings	1.3	2.2	4.0	-2.0	-0.8	-0.4	2.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.1	-0.6	0.8	-0.1	1.1
Hearing difficulty/problems: Yes	0.4	0.5	0.7	-0.8	-0.9	0.8	-0.2
Relative age of first facial hair	1.1	2.2	7.2	-0.8	2.7	-0.9	-0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.2	-0.1	0.1	-1.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.2	-0.3	-1.5	0.1	0.0
Ever had hysterectomy (womb removed)	2.1	2.4	4.7	-2.1	-0.7	-2.2	-0.2
Systolic blood pressure, automated reading	0.2	0.7	1.2	-0.7	1.1	-1.1	-0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.7	1.3	0.6	-0.0	0.2
Angina	0.7	0.9	2.6	-1.0	-0.3	-1.6	-0.2
Medication for hormone replacement therapy	0.2	0.2	0.7	-0.2	-0.9	0.1	-0.2
Vitamin and mineral supplements	0.5	0.7	1.5	-0.4	1.2	0.8	-0.6
Supplements: Zinc	0.6	0.7	2.5	0.3	1.6	0.4	-0.2
Medication: Co-codamol	1.3	1.5	4.9	-0.4	2.2	0.5	0.9
Medication: Metformin	2.1	2.9	7.0	2.6	1.5	1.5	-0.6
Diabetes (father)	1.9	2.4	3.1	1.7	1.8	1.6	-1.1
Diabetes (mother)	0.9	1.1	2.7	1.6	0.6	1.0	0.5
Severe depression (siblings)	0.6	0.6	1.9	-0.4	-1.4	0.7	0.1
Pack years adult smoking proportion	0.3	0.5	1.6	-0.5	-0.0	-1.2	0.5
Impedance of leg (right)	0.5	2.2	7.7	0.7	-2.8	0.1	-0.9
Leg fat-free mass (left)	0.9	4.5	8.8	-3.0	-0.3	-2.3	1.9
Trunk fat percentage	0.3	1.1	1.8	-1.2	0.1	-1.4	1.1
Hand grip strength (right)	0.7	1.9	5.8	-1.1	-0.5	-0.4	2.4
Townsend deprivation index at recruitment	1.6	2.3	3.8	-1.4	-0.4	-1.8	2.0
Current tobacco smoking	0.3	0.5	1.1	0.6	0.5	-1.1	-0.6
Average weekly fortified wine intake	0.3	0.4	1.2	0.3	0.3	1.1	-0.4
Maternal smoking around birth	1.9	2.8	4.6	-1.8	-2.1	-1.0	1.5
Fed-up feelings	2.2	4.1	14.0	-1.3	0.5	-0.6	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	8.5	0.6	1.8	0.9	2.9
Relative age voice broke	1.2	1.8	4.2	-0.2	2.0	-0.6	-1.7
Taking other prescription medications	0.3	0.5	1.0	-0.4	-0.9	0.2	1.0
Age when periods started (menarche)	0.9	2.1	5.9	-1.2	-2.4	-0.6	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.0	-0.2	-0.2	-1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.1	13.5	0.5	-2.4	1.0	3.7
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.1	0.6	1.8	-1.1	1.6
Qualifications: CSEs or equivalent	0.4	0.5	1.0	1.0	0.6	0.4	-0.6
Serious illness, injury or assault to yourself	0.7	0.9	1.4	0.9	1.1	-1.2	0.4
High blood pressure	0.7	2.0	4.3	-1.8	-0.5	-2.1	0.4
Hayfever, allergic rhinitis or eczema	5.4	11.8	17.6	4.2	-4.0	3.6	0.6
Multivitamins +/- minerals	0.5	0.7	1.8	0.3	-1.4	-0.6	0.6
Stomach or abdominal pain in last month	0.4	0.5	1.8	-0.1	0.4	-1.4	-0.0
Supplements: Glucosamine	0.4	0.5	1.1	0.5	-1.0	0.9	0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.1	-1.1	0.2	0.2	1.0
Medication: Atenolol	3.6	4.5	7.9	-2.8	-2.6	-1.9	-0.2
Medication: Levothyroxine sodium	0.7	1.1	2.7	0.5	-1.2	-0.0	1.6
Sitting height	0.2	1.7	2.7	-1.4	-0.4	-1.5	1.6
Chronic bronchitis/emphysema (father)	1.4	1.6	2.3	1.3	0.8	1.4	1.5
High blood pressure (mother)	0.3	0.4	1.0	0.7	-0.3	1.0	-0.2
Body mass index (BMI)	0.5	2.3	6.2	0.0	2.5	-0.9	1.4
Impedance of leg (left)	0.5	2.3	8.5	0.4	-2.9	0.0	-0.6
Leg predicted mass (left)	0.9	4.6	9.0	-3.0	-0.3	-2.3	2.0
Trunk fat mass	0.7	2.8	4.3	-1.9	0.1	-2.1	1.8
Waist circumference	0.3	0.9	1.9	-0.5	0.2	-1.4	1.3
Number of incorrect matches in round	0.9	1.6	2.7	-1.6	-1.5	-1.0	0.4
Past tobacco smoking	0.3	0.6	1.2	-0.6	-1.1	-0.7	-0.6
Alcohol usually taken with meals	0.3	0.5	1.1	0.3	-1.0	0.3	-0.8
Nervous feelings	0.1	0.2	0.5	0.3	0.1	0.7	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	5.8	0.1	1.0	-0.2	2.4
Hearing difficulty/problems with background noise	0.7	1.2	3.7	-0.3	-0.3	1.9	0.9
Hair/balding pattern: Pattern 2	1.8	2.3	4.5	-1.6	0.3	-1.4	2.1
Had menopause	1.2	1.5	2.5	0.8	-1.6	1.0	-1.2
Had other major operations	1.3	1.5	4.2	-0.9	-0.9	-2.1	0.5
Forced vital capacity (FVC)	0.5	2.1	4.0	-1.2	-1.0	-1.3	2.0
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	8.1	0.8	-2.6	1.3	2.9
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.3	1.8	1.7	1.3	-0.0
Qualifications: None of the above	0.4	0.8	2.2	-0.5	0.7	-0.3	1.5
Financial difficulties in last 2 years	0.3	0.3	0.7	0.3	-0.6	-0.4	0.9
Mouth/teeth dental problems	2.4	3.6	8.3	-1.8	-2.9	-1.6	-0.5
Heart attack	1.2	1.5	2.6	-1.2	0.4	-1.6	1.5
Allergy	5.5	12.7	22.6	-4.8	3.4	-3.7	-1.7
Pain all over the body in last month	0.7	0.7	1.9	-1.4	0.8	-0.5	0.4
Diabetes (self-reported)	1.4	2.1	6.8	2.6	0.6	1.0	-0.6
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	4.4	0.5	-2.1	-0.1	1.6
Medication: Ramipril	0.4	0.5	1.1	-0.9	0.0	-1.0	-0.5
Medication: Simvastatin	1.5	2.3	3.2	1.8	1.6	1.8	0.0
Fluid intelligence score	0.4	0.9	1.5	-0.9	-0.9	-1.2	0.8
Illnesses of siblings	0.7	0.9	2.2	-0.1	1.1	0.5	-1.5
Neuroticism score	1.1	2.3	8.5	-0.2	0.3	0.8	2.9
Weight	0.8	3.8	5.8	-2.3	0.2	-2.4	2.1
Impedance of arm (right)	1.1	5.3	15.4	0.5	-3.9	1.3	-2.0
Arm fat percentage (right)	0.2	0.6	1.9	0.6	1.4	-0.1	0.6
Trunk fat-free mass	1.0	6.0	9.8	-3.1	-0.6	-2.5	2.7
Hip circumference	1.5	6.3	12.5	-3.5	-0.3	-2.3	2.7
Time employed in main current job	0.2	0.3	0.6	0.8	0.5	0.3	-0.1
Alcohol intake versus 10 years previously	0.7	1.1	2.1	0.3	-1.4	-1.4	-0.5
Father’s age at death	0.8	1.1	2.3	-1.5	-0.6	-0.0	1.3
Worrier / anxious feelings	0.4	0.8	1.7	-0.3	-0.2	1.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.7	7.3	-1.7	-0.4	-2.1	2.7
Falls in the last year	0.2	0.2	0.5	-0.6	-0.7	0.1	0.1
Hair/balding pattern: Pattern 3	0.9	1.3	2.9	1.7	1.4	0.5	-0.0
Number of live births	0.3	0.4	0.9	-0.4	-1.0	0.2	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.7	-1.1	-0.8	-1.3	0.7
Pulse rate	1.5	2.5	5.8	0.9	-1.7	0.8	-2.4
Happiness	0.4	0.5	1.5	-0.5	-1.2	0.2	0.1
Noisy workplace	0.9	1.1	3.6	-1.9	-0.2	-0.4	-0.7
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.0	-0.5	-1.0	-0.4	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	0.4	-0.3	-0.7	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	-0.3	1.4	-0.9	-0.1
Asthma	5.9	11.6	31.0	5.6	-1.1	3.4	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.6	-2.4	-0.5	-0.3	1.5
Medication: Cholesterol lowering	0.1	0.1	0.3	0.3	0.6	-0.0	-0.3
Depression (self-reported)	0.6	0.7	1.0	0.5	-1.0	1.0	0.8
Medication: Lansoprazole	0.6	0.7	1.3	-0.5	1.0	-0.4	1.2
Prospective memory result	0.9	1.1	3.5	0.4	-0.4	0.8	-1.9
Lung cancer (father)	1.6	1.9	3.0	-1.4	1.5	-1.7	0.6
Illnesses of mother	0.1	0.1	0.2	0.4	0.2	-0.0	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.6	-0.6	-0.6	-0.8	0.5
Pulse wave Arterial Stiffness index	2.3	2.7	4.2	-1.8	-0.7	-1.7	2.1
Impedance of arm (left)	1.3	6.2	19.7	-0.4	-4.4	0.7	-2.1
Arm fat mass (right)	0.2	0.9	1.5	-0.3	1.2	-0.7	1.2
Trunk predicted mass	1.1	6.2	10.2	-3.2	-0.6	-2.6	2.8
Standing height	1.6	16.2	27.5	-5.2	-4.8	-3.3	1.7
Length of working week for main job	1.0	1.1	3.0	0.0	1.1	0.2	1.7
Exposure to tobacco smoke at home	0.3	0.3	0.7	-0.6	-0.1	-0.8	0.3
Breastfed as a baby	0.3	0.3	0.6	0.5	0.1	0.6	0.8
Tense / ‘highly strung’	1.2	2.0	5.3	0.7	-0.6	2.3	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.2	0.5	1.1	-0.3	1.1
Hair/balding pattern: Pattern 4	1.5	3.5	8.0	-1.6	-2.8	-1.0	-1.6
Birth weight of first child	0.4	0.8	2.8	0.5	-0.1	0.3	1.7
Peak expiratory flow (PEF)	0.3	0.7	1.5	-1.0	-0.6	-1.2	0.1
Pulse wave reflection index	3.4	4.2	10.8	-1.8	1.2	-1.2	3.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.5	0.1	0.7	1.2	1.6
Loud music exposure frequency	0.7	0.7	2.5	-0.1	-1.6	0.6	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.3	-0.4	-1.1	-0.4	0.3
Mouth/teeth dental problems: Bleeding gums	2.9	3.7	7.5	2.0	2.7	1.8	0.2
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.1	0.2	0.3	0.6
Medication: Paracetamol	3.4	5.7	8.7	-2.5	-3.0	-1.5	2.4
Headache pain in last month	1.2	2.0	5.3	-0.5	-1.6	0.3	2.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.7	1.3	0.3	1.6	-0.1
Glaucoma (self-reported)	3.0	3.5	8.8	0.5	-3.0	1.3	-1.8
Gout (self-reported)	4.5	6.2	14.7	-1.9	-3.8	-2.4	0.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.6	0.7	-1.9	0.6	1.4
Medication: Amlodipine	2.6	3.7	8.1	-1.0	-2.8	-2.3	0.6
Medication: Ventolin 100micrograms inhaler	3.6	4.6	13.5	3.7	-0.7	1.9	1.0
Birth weight	0.9	1.9	5.2	1.3	2.3	0.9	0.1
Chronic bronchitis/emphysema (mother)	1.4	1.7	4.6	-1.4	0.1	-0.3	2.1
High blood pressure (siblings)	0.2	0.2	0.3	-0.4	-0.4	-0.5	0.5
Forced vital capacity (FVC), Best measure	0.3	1.0	3.4	-0.1	-0.6	-0.1	1.8
Body fat percentage	0.2	1.0	1.7	-0.5	0.8	-1.3	1.1
Leg fat percentage (right)	0.4	1.6	3.0	0.5	1.7	-1.5	0.9
Arm fat-free mass (right)	1.2	6.3	10.0	-3.2	0.1	-2.9	2.6
Exposure to tobacco smoke outside home	1.2	1.6	4.2	0.5	-1.2	0.8	2.0
Comparative body size at age 10	2.4	6.6	20.2	1.3	4.5	1.6	1.4
Number of full brothers	0.0	0.0	0.0	0.1	-0.1	0.1	0.2
Worry too long after embarrassment	0.8	1.3	2.6	-0.0	0.7	1.4	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	-0.9	-1.4	0.1	0.6
Wheeze or whistling in the chest in last year	1.5	2.7	8.9	3.0	-0.2	1.3	-0.0
Number of children fathered	1.6	1.8	5.5	-0.1	1.2	-0.4	2.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	2.9	1.7	0.7	1.6	-0.3
Age at first live birth	1.1	2.0	5.7	-2.4	-1.1	-0.8	0.7
Pulse wave peak to peak time	1.9	2.2	3.5	1.5	0.4	1.7	-1.9
Health satisfaction	1.0	1.3	2.9	1.1	1.7	0.1	-0.9
Shortness of breath walking on level ground	0.2	0.3	0.7	0.8	0.5	-0.3	-0.2
Qualifications: College or University degree	1.2	3.7	10.2	-1.3	-1.6	-0.7	-3.2
Eye problems/disorders: None of the above	1.6	1.8	4.9	1.1	2.2	0.4	-0.9
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.4	2.3	1.1	1.2	-0.5
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.8	0.4	-0.0	-0.1
Medication for pain relief, constipation, heartburn	2.2	3.7	5.5	2.0	2.2	0.7	-2.4
Neck or shoulder pain in last month	0.8	1.1	2.4	1.2	0.8	1.5	0.1
Medication: Blood pressure	1.7	3.1	4.9	-2.2	-2.1	-1.7	-0.1
Angina (self-reported)	0.8	1.0	3.1	-0.9	-0.1	-1.8	0.0
Migraine (self-reported)	0.8	1.0	2.1	1.4	0.0	1.3	0.4
Medication: Ibuprofen	1.8	2.2	5.1	-2.3	-0.2	-0.6	1.8
Medication: Allopurinol	4.3	5.8	12.9	-1.9	-3.6	-2.5	0.8
Medication: Omeprazole	0.6	0.7	1.5	-0.3	1.1	-1.2	0.0
Medication: Seretide 50 evohaler	0.9	1.1	1.7	1.0	-1.3	0.7	-1.0
Mean time to correctly identify matches	2.9	5.5	8.1	2.3	2.8	2.4	-1.6
Heart disease (mother)	0.2	0.3	0.7	0.2	-0.8	0.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.6	-0.3	-0.4	-0.8
Whole body fat mass	0.5	2.2	4.0	-1.4	0.8	-2.0	1.5
Leg fat mass (right)	0.6	2.2	3.4	-0.5	1.8	-1.8	1.4
Arm predicted mass (right)	1.3	6.7	10.7	-3.3	0.1	-3.0	2.7
Pulse rate, automated reading	1.3	4.3	7.6	-2.0	-2.8	-1.0	-2.2
Alcohol intake frequency.	2.7	6.3	12.5	-2.6	-0.7	-3.5	2.3
Comparative height size at age 10	1.7	9.5	22.0	-4.7	-2.9	-2.6	0.9
Number of full sisters	0.9	1.1	2.7	0.2	-1.7	0.6	-1.1
Suffer from ‘nerves’	1.1	1.8	2.8	1.0	1.7	1.6	0.8
Overall health rating	0.7	1.4	4.0	1.2	2.0	-0.5	0.4
Chest pain or discomfort	0.4	0.6	1.4	0.6	-0.7	-1.2	-0.6
Had major operations	2.2	2.6	6.6	-1.1	0.7	-1.5	2.6
Age at last live birth	0.5	0.8	1.6	-1.3	-0.4	-0.9	0.7
Family relationship satisfaction	3.1	3.8	7.1	2.1	0.3	2.7	-1.9
Leg pain on walking	0.8	1.0	2.0	1.0	1.4	0.8	-0.7
Qualifications: NVQ or HND or HNC or equivalent	3.5	4.2	5.8	2.3	1.8	1.6	-2.4
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	0.4	0.4	-0.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	-0.2	0.9	0.9	-1.1
Medication: Aspirin	1.0	1.3	3.3	-1.1	-1.8	-0.4	0.7
Supplements: Vitamin C	0.1	0.2	0.6	-0.3	-0.1	0.2	0.8
Knee pain experienced in last month	1.4	2.1	4.6	-0.2	2.1	-0.9	1.7
Hypertension (Self-reported)	1.1	2.9	4.9	-2.2	-1.3	-2.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.1	-0.7	1.0	0.7	1.0
Illnesses of father: Heart disease	0.4	0.5	1.2	1.1	-0.7	-0.6	-0.1
Illnesses of siblings: Diabetes	0.5	0.6	1.4	1.2	-0.7	0.4	0.5
Smoking status: Previous	0.7	1.0	1.5	0.7	1.1	1.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.1	-0.7	-1.0	-0.4	1.1
Whole body fat-free mass	1.1	6.2	11.0	-3.3	-0.5	-2.7	2.5
Leg fat-free mass (right)	1.0	5.3	10.8	-3.3	-0.4	-2.4	2.2
Arm fat percentage (left)	0.1	0.4	1.2	0.2	1.1	-0.4	0.4
Average weekly red wine intake	2.4	3.5	6.1	2.5	1.4	1.3	-2.0
Handedness (chirality/laterality): Left-handed	1.6	1.9	4.0	0.2	-0.1	2.0	1.9
Mood swings	0.5	0.8	2.6	0.7	-0.3	0.4	1.6
Loneliness, isolation	1.0	1.3	3.6	1.0	0.2	0.8	1.9
Long-standing illness, disability or infirmity	0.9	1.4	2.5	0.4	1.6	-1.3	-1.1
Ever had bowel cancer screening	0.3	0.3	0.7	-0.9	0.5	-0.5	-0.2
Diabetes diagnosed by doctor	2.2	3.6	10.3	3.2	0.5	1.8	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.8	-0.9	0.3	-1.9	1.5
Friendships satisfaction	6.2	7.7	20.4	3.2	-0.1	4.5	-0.5
Qualifications: nursing, teaching	1.3	2.0	6.9	-1.0	-2.6	-0.2	-0.4
Commuting to job workplace: Walk	0.4	0.4	1.1	-0.0	-1.0	0.4	-0.6
Eye problems/disorders: Cataract	1.7	1.9	4.8	-1.2	-2.2	-1.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.1	1.1	0.3	1.0	-0.9
Medication for cholesterol	0.1	0.2	0.4	-0.0	0.5	0.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	0.9	-0.2	0.3	0.6
Back pain experienced in last month	1.3	1.9	3.0	-1.5	-1.1	-1.7	1.1
Mineral and other dietary supplements	1.6	2.1	5.4	0.0	2.3	-1.2	-1.2
Breast cancer (self-reported)	3.4	4.0	11.8	-3.4	0.2	-2.0	0.5
Asthma (self-reported)	5.5	11.0	28.7	5.4	-1.4	3.4	1.4
Osteoporosis (self-reported)	0.5	0.7	2.2	-0.4	0.0	-0.5	-1.5
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.5	-0.9	-0.1	-0.2
Medication: Aspirin	1.5	2.0	5.2	-1.5	-2.3	-0.4	0.6
Medication: Gliclazide	1.0	1.1	2.4	1.2	0.1	1.5	-0.9
Illnesses of father: None of the above (group 1)	0.8	1.0	3.5	-1.9	0.4	-0.7	0.2
Smoking status: Current	0.4	0.6	1.0	0.6	0.3	-1.0	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.1	-0.2	1.4	-0.1	0.4
Whole body water mass	1.1	6.3	11.0	-3.3	-0.3	-2.7	2.6
Leg predicted mass (right)	1.0	5.4	11.0	-3.3	-0.5	-2.3	2.2
Arm fat mass (left)	0.2	1.0	1.6	-0.7	1.0	-0.9	1.3
Number of self-reported non-cancer illnesses	0.7	1.1	3.6	0.6	-1.9	0.1	0.8
Average weekly champagne plus white wine intake	2.2	3.0	9.5	0.1	-3.1	0.6	-1.5
Miserableness	0.2	0.4	0.9	0.3	-0.4	-0.6	0.9
Guilty feelings	1.3	2.0	3.6	-1.2	-1.3	1.1	1.9
Wears glasses or contact lenses	0.1	0.1	0.3	-0.3	0.5	-0.1	-0.1
Ever taken oral contraceptive pill	1.0	1.1	3.7	0.5	0.0	0.8	1.9
Hearing aid user	2.0	2.2	6.6	-2.6	-1.4	0.4	-0.2
Mother’s age at death	0.5	0.6	0.9	-0.0	0.9	0.7	-1.0
Financial situation satisfaction	0.3	0.4	1.0	-0.1	-0.7	1.0	0.1
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.9	-2.0	-0.3	-1.5	0.3
Commuting to job workplace: Public transport	0.8	0.9	2.0	1.1	0.2	1.4	-0.5
Eye problems/disorders: Glaucoma	1.6	1.9	4.9	0.4	-2.2	0.7	-1.5
Medication: Blood pressure	1.0	1.9	4.4	-0.5	-1.7	-2.1	-0.0
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.8	-1.3	-0.3	-1.0	0.6
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.4	-0.1	-2.1	1.2	1.5
High cholesterol (Self-reported)	0.7	1.2	2.7	0.7	1.6	1.0	0.6
Medication: Bendroflumethiazide	1.8	2.8	6.8	-2.0	-0.0	-2.6	-0.6
Medication: Paracetamol	2.8	4.3	7.3	-2.2	-1.7	-1.4	2.7
Medication: Lisinopril	0.6	0.8	1.6	-1.2	-1.0	-0.7	-0.2
Medication: Atorvastatin	1.7	2.1	3.1	-1.6	-1.6	-1.8	-0.3
Illnesses of father: High blood pressure	0.4	0.5	1.7	0.1	-1.3	-0.2	0.6
Alcohol drinker status: Never	1.4	1.7	5.4	-1.1	0.3	-0.2	2.3
Ever smoked	0.1	0.2	0.4	0.6	0.2	0.1	0.4
Basal metabolic rate	1.0	5.7	9.6	-3.1	-0.3	-2.6	2.5
Leg fat percentage (left)	0.4	1.4	2.5	0.3	1.4	-1.6	1.1
Arm fat-free mass (left)	1.1	5.8	9.7	-2.7	0.2	-2.4	3.1
Number of operations (self-reported)	2.0	3.0	9.4	-0.5	0.5	-1.4	3.1
Average weekly beer plus cider intake	0.4	0.5	1.1	1.1	0.3	0.4	-0.8
Irritability	0.5	0.8	1.6	0.5	-1.2	0.2	1.3
Risk taking	0.4	0.6	1.3	1.2	-0.8	-0.3	-0.6
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.9	-1.2	1.7	-0.3	0.6
Fractured/broken bones in last 5 years	2.3	3.0	6.7	-1.1	-1.1	-1.7	-2.6
Age started oral contraceptive pill	1.5	1.8	7.0	0.3	0.3	0.4	-2.6
Diastolic blood pressure, automated reading	0.9	2.8	7.6	-1.9	-0.5	-2.8	0.1
Ever depressed for a whole week	1.2	1.5	3.6	1.2	1.9	0.8	0.7
Unable to work because of sickness or disability	1.3	1.7	2.7	-1.5	0.9	-1.6	0.9
Commuting to job workplace: Cycle	0.7	0.9	2.5	-0.5	1.6	-0.1	-0.9
Myopia	0.5	0.8	1.2	-1.0	-0.4	-1.1	0.9
Vascular/heart problems diagnosed by doctor	1.2	3.3	6.6	2.3	0.5	2.6	-1.1
Cholesterol lowering medication	0.7	1.0	1.6	0.9	1.2	0.5	1.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.9	-1.1	0.2	-1.4	0.6
Pain experienced in last month	0.6	1.1	2.3	-0.8	-1.1	0.1	-1.5
Supplements: Calcium	0.6	0.7	1.2	0.6	-0.3	1.1	-1.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	0.1	1.1	0.3	1.0
Heart attack/myocardial infarction (self-reported)	1.3	1.6	3.1	-1.2	0.3	-1.8	1.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	-0.2	0.0	0.6	0.8
Heart disease (siblings)	1.0	1.2	3.7	0.7	-0.3	0.6	1.9
Alcohol drinker status: Previous	1.3	1.5	3.1	-0.6	1.4	-0.8	1.8
Pack years of smoking	0.4	0.6	1.9	-0.8	-0.1	-1.4	0.3
Impedance of whole body	0.8	3.9	11.7	0.6	-3.4	0.8	-1.8
Leg fat mass (left)	0.6	2.2	3.6	-0.7	1.5	-1.9	1.6
Arm predicted mass (left)	1.1	5.6	8.8	-2.6	0.4	-2.6	3.0