Hub : Genes

APBA2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0210	0.0076	2.1e-04	0.008	0.010	0.010	0.01	0.008	7.4e-04	1.8e-04	3.3e-04	3.1e-04	8.8e-04
2	YFS	Blood	0.0928	0.0214	2.6e-14	0.024	0.057	0.080	0.08	0.077	1.5e-08	4.6e-18	8.9e-25	9.4e-25	4.0e-24
3	TCGA	Stomach Adenocarcinoma	0.1730	0.0710	1.2e-03	0.047	0.034	0.021	NA	0.039	2.4e-04	1.7e-03	1.0e-02	NA	8.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	2.0	-1.4	-0.6	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.8	1.7	-0.6	-1.3	-0.7
Depressed Affect (Nagel 2018)	0.3	0.6	1.8	-0.3	-1.3	-0.1
Depression (Nagel 2018)	0.3	0.5	1.3	-0.2	-1.1	0.2
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.2	1.1	1.8	1.1
Neuroticism (Nagel 2018)	0.4	0.9	2.4	-0.4	-1.6	-0.1
Schizophrenia (2018)	0.3	0.6	1.3	0.4	-1.2	-0.5
Schizophrenia vs Biploar Disorder	1.4	1.8	3.9	2.0	1.2	0.3
Worry (Nagel 2018)	0.2	0.4	0.6	0.7	-0.8	-0.4
Alzheimer’s Disease (in mother)	1.3	1.5	2.8	-0.4	1.2	1.7
Alzheimer’s Disease (in father)	1.4	1.5	2.9	-0.5	1.2	1.7
Alzheimer’s Disease (including proxy)	2.1	3.0	5.7	-0.4	1.8	2.4
Crohns Disease (2017)	0.8	1.7	2.9	-1.1	-1.7	-1.0
Irritable Bowel Disease (IBD)	0.5	1.1	1.5	-0.8	-1.2	-1.1
Ulcerative Colitis (UC)	0.1	0.1	0.2	0.3	0.3	-0.5
Major Depression (MDD)	0.2	0.2	0.5	0.4	0.7	0.0
Reaction Time	0.0	0.0	0.0	-0.1	0.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.9	-0.6	0.5	0.9
Breast Cancer	1.7	4.2	8.5	1.1	2.9	1.7
Ovarian Cancer	1.0	1.3	2.9	1.7	1.0	-0.2
Prostate Cancer	0.8	1.2	1.7	0.9	1.0	1.3
Age at First Birth	1.3	1.8	4.2	-0.6	1.0	2.0
Bipolar Disorder (2011)	0.4	0.4	0.5	0.7	0.3	-0.7
Body Mass Index (BMI) (2010)	1.0	1.4	1.7	-1.3	1.0	1.3
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.1	0.7	0.5
Crohns Disease (2012)	0.3	0.4	1.2	-0.3	-1.1	-0.2
Mean Putamen Volume	0.3	0.4	0.7	0.9	0.6	-0.3
Fasting Glucose	1.8	2.2	5.9	2.4	0.8	-0.3
HbA1C	0.9	1.0	1.5	-0.7	-1.2	-1.0
HDL Cholesterol	0.2	0.4	0.7	0.5	0.9	0.3
LDL Cholesterol	0.2	0.3	0.7	-0.0	-0.6	-0.9
Lupus	0.6	0.9	2.1	0.2	-1.4	-0.7
Neuroticism (2016)	0.2	0.3	0.6	0.3	-0.4	-0.8
Primary Biliary Cirrhosis	0.2	0.2	0.3	0.5	0.5	0.4
Rheumatoid Arthritis	0.2	0.3	0.5	-0.3	-0.5	-0.7
Schizophrenia (2014)	0.4	0.8	1.3	0.4	-1.1	-1.0
Triglycerides	0.6	1.0	1.4	-0.7	-1.2	-1.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.4	0.4	-0.9	-1.2
Ulcerative Colitis	0.9	1.3	2.0	1.0	1.4	1.0
Blood Eosinophil Count	0.0	0.3	0.4	-0.6	0.4	0.5
Blood Platelet Count	0.1	1.2	2.1	-0.7	-1.5	-1.0
Blood Red Count	0.3	2.8	5.1	-1.5	-2.2	-1.1
Blood White Count	0.0	0.1	0.2	0.1	-0.5	-0.4
Heel T-Score	0.0	0.3	0.5	-0.5	-0.2	0.7
BMI	0.1	0.5	1.3	0.3	0.2	1.2
Height	0.1	2.8	3.9	-1.5	-2.0	-1.5
Waist Hip Ratio (WHR)	0.5	2.1	3.3	-1.3	-1.8	-1.1
Systolic Blood Pressure	0.2	1.0	2.1	0.9	1.4	0.4
Smoking Status	0.3	0.7	1.3	-0.7	-0.6	-1.1
Allergy or Eczema	0.6	1.6	2.7	0.3	-1.7	-1.4
Cardiovascular Disease	0.5	1.6	2.6	1.0	1.6	1.2
Hypothyroidism (self reported)	0.0	0.0	0.1	0.2	-0.2	0.3
Respiratory disease	0.2	0.4	0.7	-0.8	0.5	0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.5	-0.5	-1.6	-0.7
Lung FEV1/FVC ratio	0.4	1.8	3.2	0.6	1.8	1.4
Lung FVC	0.2	1.1	1.8	-1.3	0.5	1.2
Neuroticism	0.4	1.0	2.6	-0.6	-1.6	-0.4
Chronotype (morning person)	0.7	1.7	3.3	-1.8	-0.1	1.3
Hair Pigment	1.3	36.7	62.4	-7.9	-0.2	6.9
Tanning	0.4	5.4	10.7	1.9	-1.4	-3.3
Hand grip strength (left)	0.1	0.2	0.5	0.7	0.0	0.5
Number of treatments/medications taken	0.4	0.6	1.2	1.1	-0.2	-0.8
Average weekly spirits intake	0.1	0.1	0.4	0.6	0.0	0.3
Sensitivity / hurt feelings	0.4	0.7	1.1	-0.1	-1.1	-0.9
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	-0.0	-0.4	0.4
Hearing difficulty/problems: Yes	0.3	0.5	0.8	0.4	-0.7	-0.9
Relative age of first facial hair	0.5	0.9	2.0	-1.4	-0.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	0.4	-0.7	-0.9
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.0	-1.1	-1.7	-0.1
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	1.1	0.4	-0.3
Systolic blood pressure, automated reading	0.8	2.4	4.7	1.1	2.2	1.1
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.3	-0.6	-2.1	-0.8
Angina	1.0	1.3	2.2	-1.5	-1.3	-0.1
Medication for hormone replacement therapy	1.5	1.7	3.4	0.0	-1.9	-1.2
Vitamin and mineral supplements	1.1	1.5	2.7	-1.6	-1.4	0.3
Supplements: Zinc	0.6	0.7	1.0	0.6	-0.8	-1.0
Medication: Co-codamol	0.3	0.4	0.6	-0.7	0.3	0.7
Medication: Metformin	0.3	0.4	1.1	-0.0	-1.1	-0.1
Diabetes (father)	0.6	0.8	1.1	-1.0	0.4	1.1
Diabetes (mother)	1.4	1.8	2.8	-0.0	-1.6	-1.7
Severe depression (siblings)	1.7	1.9	4.2	-1.1	0.6	2.1
Pack years adult smoking proportion	0.8	1.2	2.0	-1.1	0.5	1.4
Impedance of leg (right)	0.2	0.9	1.4	-1.2	0.6	1.0
Leg fat-free mass (left)	0.0	0.3	0.7	-0.2	-0.9	-0.1
Trunk fat percentage	0.0	0.2	0.4	-0.3	-0.7	-0.3
Hand grip strength (right)	0.1	0.2	0.4	0.5	-0.7	0.1
Townsend deprivation index at recruitment	0.4	0.5	0.9	0.0	-0.9	-0.9
Current tobacco smoking	0.2	0.3	1.0	-1.0	-0.1	0.2
Average weekly fortified wine intake	3.0	3.6	7.8	-1.2	-2.8	-1.2
Maternal smoking around birth	0.5	0.8	1.5	-1.2	-0.2	-0.9
Fed-up feelings	0.7	1.2	2.2	-1.5	-0.3	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.1	-1.0	-1.0	-0.2
Relative age voice broke	0.4	0.6	1.0	-1.0	-0.2	0.9
Taking other prescription medications	0.5	0.8	1.5	1.2	0.1	-0.9
Age when periods started (menarche)	0.1	0.3	0.6	-0.3	0.8	-0.3
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	4.8	0.6	-1.9	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.0	1.7	0.7	-0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.1	-0.6	-0.6
Qualifications: CSEs or equivalent	1.0	1.3	2.3	-1.5	-1.2	-0.4
Serious illness, injury or assault to yourself	3.1	3.8	8.9	1.0	-1.3	-3.0
High blood pressure	1.0	2.8	4.5	2.1	1.7	1.0
Hayfever, allergic rhinitis or eczema	1.2	2.6	4.2	0.3	-1.9	-2.1
Multivitamins +/- minerals	1.7	2.2	4.1	2.0	1.6	-0.0
Stomach or abdominal pain in last month	0.2	0.3	0.5	-0.1	-0.7	-0.6
Supplements: Glucosamine	0.2	0.3	0.7	-0.3	-0.8	-0.4
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.5	-0.5	-1.1	-1.6
Medication: Atenolol	2.2	2.7	3.7	1.9	1.9	1.0
Medication: Levothyroxine sodium	0.4	0.7	1.9	-0.1	-1.4	-0.5
Sitting height	0.0	0.3	0.9	-0.1	-0.9	0.3
Chronic bronchitis/emphysema (father)	1.4	1.6	2.5	-0.1	-1.6	-1.5
High blood pressure (mother)	3.4	4.8	7.4	2.5	2.7	0.9
Body mass index (BMI)	0.1	0.3	0.5	0.5	-0.7	-0.4
Impedance of leg (left)	0.1	0.4	1.1	-1.0	-0.0	0.2
Leg predicted mass (left)	0.1	0.3	0.9	-0.2	-1.0	-0.3
Trunk fat mass	0.1	0.3	0.6	-0.2	-0.8	-0.3
Waist circumference	0.1	0.4	0.7	-0.1	-0.8	-0.6
Number of incorrect matches in round	0.9	1.4	3.3	1.8	0.6	-0.8
Past tobacco smoking	0.2	0.3	0.6	0.5	0.2	0.8
Alcohol usually taken with meals	1.0	1.6	3.0	-1.3	-1.7	-0.5
Nervous feelings	0.5	1.0	1.3	-0.7	1.0	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.2	-1.2	-0.0	1.5
Hearing difficulty/problems with background noise	0.7	1.1	2.2	0.3	-1.5	-1.0
Hair/balding pattern: Pattern 2	0.6	0.8	1.8	-0.6	0.4	1.3
Had menopause	0.2	0.2	0.3	-0.4	-0.5	-0.5
Had other major operations	0.5	0.7	1.6	-0.1	-0.6	-1.3
Forced vital capacity (FVC)	0.4	1.5	3.7	-1.9	-0.5	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	1.1	0.7	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	1.2	0.3	0.2
Qualifications: None of the above	0.1	0.2	0.3	-0.2	-0.4	-0.5
Financial difficulties in last 2 years	1.2	1.6	3.1	-1.8	-1.2	0.5
Mouth/teeth dental problems	0.5	0.7	1.0	-1.0	0.7	0.9
Heart attack	1.2	1.5	1.6	-1.2	-1.3	-1.1
Allergy	1.5	3.5	5.2	0.4	2.2	2.3
Pain all over the body in last month	0.3	0.3	0.9	0.3	-0.9	-0.2
Diabetes (self-reported)	0.7	1.0	2.8	1.7	-0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	8.3	2.9	1.3	-0.8
Medication: Ramipril	0.7	0.9	1.0	-0.8	-1.0	-1.0
Medication: Simvastatin	0.5	0.7	0.8	0.8	0.9	0.9
Fluid intelligence score	0.3	0.7	1.5	-1.2	-0.8	-0.1
Illnesses of siblings	0.3	0.4	1.1	-1.0	-0.1	0.4
Neuroticism score	0.4	0.9	2.0	-0.8	-1.4	-0.4
Weight	0.1	0.3	0.7	0.2	-0.9	-0.4
Impedance of arm (right)	0.2	1.2	2.6	-0.2	1.6	0.9
Arm fat percentage (right)	0.0	0.2	0.3	0.6	-0.1	-0.4
Trunk fat-free mass	0.0	0.1	0.1	0.3	-0.4	0.0
Hip circumference	0.0	0.1	0.2	-0.2	-0.4	-0.3
Time employed in main current job	1.2	1.4	2.0	-1.4	-1.4	-0.6
Alcohol intake versus 10 years previously	0.9	1.3	2.3	-1.5	0.9	0.9
Father’s age at death	0.8	1.1	2.6	1.6	0.7	0.4
Worrier / anxious feelings	0.4	0.8	1.7	0.4	-0.6	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.1	0.2	0.5
Falls in the last year	1.0	1.3	2.8	-0.7	0.9	1.7
Hair/balding pattern: Pattern 3	0.7	1.1	1.6	-0.4	-1.2	-1.2
Number of live births	0.4	0.6	0.9	-0.2	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.6	-1.9	-0.5	0.9
Pulse rate	1.1	1.8	2.4	-1.2	-1.6	-1.3
Happiness	0.2	0.3	0.8	0.9	-0.2	-0.1
Noisy workplace	0.1	0.1	0.2	0.4	0.1	0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.6	1.3	0.9	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	-0.7	-0.0	0.0
Mouth/teeth dental problems: Dentures	1.3	2.1	5.1	2.3	0.6	-0.9
Asthma	0.3	0.7	1.1	-1.0	-0.6	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.1	-0.4	0.9	1.4
Medication: Cholesterol lowering	0.4	0.7	1.2	1.1	0.9	-0.2
Depression (self-reported)	2.2	2.6	4.9	0.7	-1.6	-2.2
Medication: Lansoprazole	1.6	1.8	3.0	1.7	0.7	-1.4
Prospective memory result	3.7	4.5	6.0	2.3	2.4	1.5
Lung cancer (father)	1.3	1.6	3.0	-0.2	-1.3	-1.7
Illnesses of mother	2.4	3.0	5.4	-0.5	-2.3	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.2	-1.1	0.3	0.8
Pulse wave Arterial Stiffness index	1.7	1.9	3.9	1.1	-0.7	-2.0
Impedance of arm (left)	0.3	1.4	1.9	-0.8	1.4	1.2
Arm fat mass (right)	0.1	0.4	0.7	0.1	-0.8	-0.6
Trunk predicted mass	0.0	0.1	0.1	0.3	-0.4	-0.0
Standing height	0.0	0.4	0.6	-0.7	-0.8	-0.3
Length of working week for main job	0.7	0.8	2.0	0.4	0.6	1.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.4	-0.1	0.1
Breastfed as a baby	0.6	0.7	1.0	0.8	0.6	1.0
Tense / ‘highly strung’	0.3	0.5	1.5	1.2	0.3	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	4.5	0.1	-1.7	-2.1
Hair/balding pattern: Pattern 4	0.4	0.9	1.5	-1.2	-1.0	-0.3
Birth weight of first child	0.5	1.0	1.8	-0.2	-1.3	-1.1
Peak expiratory flow (PEF)	0.4	0.9	1.2	-0.8	-1.1	-0.8
Pulse wave reflection index	2.1	2.5	5.5	2.4	0.2	-1.4
Ever highly irritable/argumentative for 2 days	0.5	0.7	1.8	0.3	-0.1	1.4
Loud music exposure frequency	1.4	1.5	3.6	1.9	1.0	0.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.5	0.4	1.1	1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	-0.9	-0.7	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.0	0.0	-1.0	-0.7
Medication: Paracetamol	0.8	1.4	2.3	-1.3	-1.5	-0.2
Headache pain in last month	0.2	0.4	0.9	-0.3	-1.0	-0.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.9	-1.4	-0.7	0.8
Glaucoma (self-reported)	0.4	0.4	1.2	1.1	0.3	-0.2
Gout (self-reported)	0.3	0.4	0.7	0.8	0.6	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	-0.4	-1.0	-0.2
Medication: Amlodipine	0.2	0.3	0.7	-0.0	-0.6	-0.8
Medication: Ventolin 100micrograms inhaler	2.5	3.2	4.9	-2.2	-1.7	-1.4
Birth weight	1.6	3.4	5.4	-1.2	-2.3	-1.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.2	-0.4	-0.5	-0.5
High blood pressure (siblings)	0.2	0.3	0.7	0.9	0.5	0.0
Forced vital capacity (FVC), Best measure	0.2	0.7	1.8	-1.4	0.2	0.4
Body fat percentage	0.1	0.3	0.6	-0.0	-0.8	-0.5
Leg fat percentage (right)	0.1	0.5	1.0	-0.2	-1.0	-0.6
Arm fat-free mass (right)	0.2	1.1	2.8	-0.5	-1.7	-0.6
Exposure to tobacco smoke outside home	0.2	0.2	0.4	-0.2	-0.4	-0.6
Comparative body size at age 10	0.6	1.5	2.6	-1.6	-1.4	-0.4
Number of full brothers	0.4	0.5	1.1	-0.6	-1.0	-0.2
Worry too long after embarrassment	0.4	0.6	0.9	-0.9	-0.6	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.2	1.5	0.5	0.0
Wheeze or whistling in the chest in last year	0.7	1.2	2.3	-0.7	0.9	1.5
Number of children fathered	0.4	0.5	0.7	0.2	-0.8	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.6	0.8	0.2	-0.4
Age at first live birth	1.0	1.7	2.6	0.8	1.6	1.4
Pulse wave peak to peak time	1.7	2.0	3.7	-1.3	0.8	1.9
Health satisfaction	0.1	0.1	0.1	-0.1	-0.4	-0.2
Shortness of breath walking on level ground	0.6	0.8	1.2	-0.3	-1.0	-1.1
Qualifications: College or University degree	0.3	0.8	1.3	-1.1	-0.0	1.1
Eye problems/disorders: None of the above	0.5	0.6	1.0	-1.0	0.2	0.8
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.5	1.9	-0.1	-0.9
Emphysema/chronic bronchitis	1.2	1.3	3.6	-1.9	-0.5	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	0.7	-0.4	0.8	0.8
Neck or shoulder pain in last month	0.4	0.5	1.1	-0.6	-0.1	1.1
Medication: Blood pressure	0.9	1.5	3.0	1.7	1.2	-0.5
Angina (self-reported)	1.1	1.4	2.6	-1.6	-1.2	-0.0
Migraine (self-reported)	0.2	0.2	0.4	-0.2	0.4	0.6
Medication: Ibuprofen	0.5	0.6	1.0	-1.0	0.4	0.8
Medication: Allopurinol	0.9	1.2	1.5	1.1	1.2	0.9
Medication: Omeprazole	1.3	1.6	2.1	1.1	-1.2	-1.4
Medication: Seretide 50 evohaler	0.6	0.7	1.3	-1.1	-0.8	0.0
Mean time to correctly identify matches	0.2	0.3	0.7	0.4	0.8	0.3
Heart disease (mother)	0.2	0.2	0.3	0.6	0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	8.0	-0.1	-1.7	-2.8
Whole body fat mass	0.1	0.5	1.1	-0.1	-1.1	-0.6
Leg fat mass (right)	0.2	0.6	1.3	-0.1	-1.1	-0.7
Arm predicted mass (right)	0.2	0.8	2.1	-0.2	-1.5	-0.5
Pulse rate, automated reading	0.1	0.2	0.4	0.0	-0.6	-0.6
Alcohol intake frequency.	0.1	0.2	0.4	0.2	0.6	-0.6
Comparative height size at age 10	0.1	0.4	0.7	-0.5	-0.8	-0.3
Number of full sisters	2.1	2.6	4.3	-0.9	-2.1	-1.6
Suffer from ‘nerves’	0.1	0.2	0.3	-0.4	-0.3	0.5
Overall health rating	0.6	1.4	2.4	-1.0	-1.5	-0.8
Chest pain or discomfort	0.3	0.4	0.7	-0.8	-0.7	0.1
Had major operations	0.2	0.2	0.6	0.7	0.3	-0.2
Age at last live birth	0.4	0.6	1.3	0.5	1.1	0.6
Family relationship satisfaction	0.2	0.2	0.4	0.6	0.4	0.4
Leg pain on walking	1.1	1.3	2.1	-0.5	-1.5	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.1	-0.0	0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	-0.8	-0.0	0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	-0.0	0.5	0.6
Medication: Aspirin	1.3	1.8	3.0	1.7	1.2	0.9
Supplements: Vitamin C	0.3	0.4	0.6	-0.8	-0.4	-0.6
Knee pain experienced in last month	0.1	0.2	0.3	-0.6	-0.0	0.3
Hypertension (Self-reported)	0.8	2.2	3.1	1.8	1.5	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	3.9	0.5	-1.7	-2.0
Illnesses of father: Heart disease	0.6	0.9	2.0	-0.1	1.4	0.8
Illnesses of siblings: Diabetes	1.5	1.9	2.5	1.1	-1.6	-1.4
Smoking status: Previous	0.2	0.2	0.7	-0.0	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.4	-1.2	0.3	0.6
Whole body fat-free mass	0.0	0.2	0.7	0.0	-0.8	-0.2
Leg fat-free mass (right)	0.1	0.4	0.9	0.0	-1.0	-0.4
Arm fat percentage (left)	0.0	0.1	0.1	0.2	-0.3	-0.2
Average weekly red wine intake	0.3	0.4	0.9	-0.3	-0.4	0.9
Handedness (chirality/laterality): Left-handed	1.8	2.1	4.2	-2.0	-0.9	-1.1
Mood swings	0.7	1.3	2.1	-1.4	-1.3	-0.0
Loneliness, isolation	1.6	2.2	3.4	-1.8	-1.8	0.1
Long-standing illness, disability or infirmity	0.4	0.6	1.1	1.1	0.5	0.6
Ever had bowel cancer screening	0.7	0.8	2.2	1.5	0.5	-0.2
Diabetes diagnosed by doctor	0.3	0.5	0.6	0.8	-0.8	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	1.7	-0.4	-1.3	-1.1
Friendships satisfaction	0.7	0.8	1.1	-1.0	-1.0	-0.7
Qualifications: nursing, teaching	0.0	0.0	0.1	-0.1	0.3	-0.1
Commuting to job workplace: Walk	4.4	4.7	8.4	2.0	-1.3	-2.9
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.3	0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.7	0.1	-0.3
Medication for cholesterol	0.3	0.5	0.8	-0.9	0.7	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.6	1.0	-0.5	-0.9	-1.0
Back pain experienced in last month	0.1	0.1	0.2	0.5	-0.4	-0.2
Mineral and other dietary supplements	0.5	0.7	1.2	-1.1	-0.8	0.1
Breast cancer (self-reported)	0.1	0.1	0.2	-0.5	-0.0	-0.3
Asthma (self-reported)	0.7	1.3	1.6	-1.3	-1.0	-1.1
Osteoporosis (self-reported)	1.2	1.5	2.5	1.6	0.9	-1.0
Osteoarthritis (self-reported)	0.4	0.5	1.1	0.5	-0.4	-1.1
Medication: Aspirin	0.6	0.8	1.2	1.1	0.8	0.7
Medication: Gliclazide	0.1	0.2	0.3	0.2	0.6	0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	-0.6	-0.3	1.1
Smoking status: Current	0.2	0.2	0.7	-0.8	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.6	-0.2	0.6	0.8
Whole body water mass	0.1	0.3	0.8	0.0	-0.9	-0.3
Leg predicted mass (right)	0.1	0.4	0.9	0.1	-1.0	-0.5
Arm fat mass (left)	0.1	0.3	0.6	0.1	-0.8	-0.4
Number of self-reported non-cancer illnesses	1.2	2.0	4.5	2.1	0.6	-1.1
Average weekly champagne plus white wine intake	1.0	1.4	2.1	0.3	1.4	1.4
Miserableness	0.1	0.1	0.3	0.0	-0.3	-0.6
Guilty feelings	1.5	2.3	4.9	-1.4	-2.2	-0.4
Wears glasses or contact lenses	0.8	0.9	1.4	0.6	1.2	1.0
Ever taken oral contraceptive pill	2.2	2.5	3.9	-1.1	1.5	2.0
Hearing aid user	0.3	0.4	0.6	-0.8	-0.7	0.2
Mother’s age at death	3.5	4.4	7.2	2.4	2.7	0.5
Financial situation satisfaction	1.9	2.4	4.3	-2.1	-1.5	0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	0.4	-0.2	-1.0
Commuting to job workplace: Public transport	0.7	0.8	2.4	1.6	0.2	-0.0
Eye problems/disorders: Glaucoma	0.2	0.3	0.3	0.4	0.6	0.6
Medication: Blood pressure	0.2	0.4	0.9	0.9	-0.4	-0.3
Pain type(s) experienced in last month: Hip pain	2.5	3.1	5.7	-2.4	-1.9	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	1.0	0.5	0.1
High cholesterol (Self-reported)	0.4	0.7	1.6	1.3	0.8	0.1
Medication: Bendroflumethiazide	1.3	2.0	4.2	2.0	1.4	-0.4
Medication: Paracetamol	0.7	1.1	1.6	-1.2	-1.3	-0.5
Medication: Lisinopril	0.4	0.6	1.0	1.0	0.8	0.1
Medication: Atorvastatin	0.0	0.0	0.1	0.1	0.3	0.0
Illnesses of father: High blood pressure	0.3	0.4	0.7	0.8	0.4	-0.7
Alcohol drinker status: Never	1.5	1.7	3.4	1.8	0.2	-1.3
Ever smoked	0.2	0.3	0.4	-0.6	0.6	0.2
Basal metabolic rate	0.0	0.3	0.8	-0.0	-0.9	-0.2
Leg fat percentage (left)	0.3	1.2	2.0	-0.2	-1.4	-1.2
Arm fat-free mass (left)	0.3	1.3	2.9	0.1	-1.7	-1.1
Number of operations (self-reported)	1.3	1.9	3.9	0.5	-1.3	-2.0
Average weekly beer plus cider intake	1.3	1.9	3.0	-0.7	1.4	1.7
Irritability	0.6	1.1	1.5	-1.2	-0.5	1.2
Risk taking	0.8	1.2	2.5	-1.0	-1.6	0.3
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	1.0	0.6	-0.4
Fractured/broken bones in last 5 years	0.9	1.1	2.4	0.2	-1.0	-1.6
Age started oral contraceptive pill	1.2	1.5	3.4	1.9	-0.2	-1.0
Diastolic blood pressure, automated reading	0.2	0.6	0.7	0.8	0.8	0.7
Ever depressed for a whole week	0.3	0.3	0.8	-0.4	-0.9	0.1
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.9	-0.5	0.1
Commuting to job workplace: Cycle	0.6	0.7	1.7	-0.2	-1.3	-0.6
Myopia	1.1	1.6	2.8	-0.7	-1.7	-1.2
Vascular/heart problems diagnosed by doctor	1.2	3.3	4.3	-2.0	-2.1	-1.3
Cholesterol lowering medication	0.3	0.4	0.7	0.4	0.6	0.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	0.3	-1.4	-1.1
Pain experienced in last month	0.4	0.7	1.3	1.1	0.8	-0.3
Supplements: Calcium	0.7	0.8	1.6	0.9	1.2	0.2
Basal cell carcinoma (self-reported)	0.7	0.8	2.2	1.5	0.6	-0.0
Heart attack/myocardial infarction (self-reported)	1.0	1.3	1.4	-1.2	-1.1	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	1.9	-0.5	-1.4	-0.7
Heart disease (siblings)	0.5	0.7	1.4	-0.7	0.3	1.2
Alcohol drinker status: Previous	1.2	1.3	3.8	-1.9	-0.4	0.1
Pack years of smoking	0.6	0.8	1.6	-1.3	-0.1	0.9
Impedance of whole body	0.1	0.7	1.7	-1.3	0.4	0.6
Leg fat mass (left)	0.3	1.1	2.2	-0.1	-1.5	-1.1
Arm predicted mass (left)	0.2	1.0	2.3	0.1	-1.5	-0.9