TWAS hub - APP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1590	0.0560	9.3e-04	0.064	NA	0.063	NA	0.071	1.0e-04	NA	1.1e-04	NA	3.9e-05
2	GTEx	Nerve Tibial	0.1659	0.0538	7.1e-04	-0.002	NA	-0.003	NA	-0.002	5.3e-01	NA	5.6e-01	NA	4.7e-01
3	YFS	Blood	0.0352	0.0104	1.6e-05	0.030	0.015	0.032	0.026	0.032	3.1e-10	9.7e-06	1.1e-10	5e-09	8.9e-11
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1440	0.0590	2.4e-03	0.068	0.027	0.062	NA	0.074	9.6e-05	1.1e-02	1.9e-04	NA	4.9e-05
5	TCGA	Prostate Adenocarcinoma	0.0754	0.0319	5.6e-04	0.028	0.037	0.027	NA	0.032	5.2e-04	8.1e-05	7.4e-04	NA	2.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Alzheimer’s Disease (including proxy)	4.7	6.8	12.2	-3.1	-3.3	-3.5	0.2	-0.9
Pulse wave Arterial Stiffness index	4.6	5.4	9.0	-2.9	-0.3	-3.0	-1.0	-2.9
Pulse wave peak to peak time	4.5	5.2	8.7	3.0	0.1	3.0	0.9	2.8
Guilty feelings	3.9	5.9	12.3	-3.5	-1.8	-2.4	2.2	1.8
Alzheimer’s Disease (in mother)	3.6	4.2	8.7	-2.7	-2.1	-2.9	0.4	-0.6
Eye problems/disorders: None of the above	3.4	3.9	7.6	-2.5	-1.7	-2.8	-0.8	-1.6
Age started oral contraceptive pill	3.3	4.2	10.7	1.9	3.3	2.0	-0.3	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	4.0	7.4	-2.7	-2.2	-2.7	-0.1	-0.8
Commuting to job workplace: Walk	2.3	2.5	3.2	-1.3	-1.8	-1.3	1.8	1.7
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	5.3	2.3	1.0	1.9	-1.5	1.0
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	8.5	-2.8	0.2	-2.9	-0.2	-1.0
Schizophrenia (2018)	2.1	4.3	12.4	-2.1	-3.5	-1.5	-1.4	-0.7
Supplements: Zinc	2.1	2.3	7.4	-1.1	-0.5	-1.3	-1.0	-2.7
Alcohol drinker status: Never	2.1	2.6	7.0	-0.8	0.2	0.5	2.2	2.6
Ovarian Cancer	2.0	2.7	7.0	-2.6	-1.1	-2.2	0.7	-0.0
Medication: Levothyroxine sodium	2.0	3.3	5.6	1.9	0.8	1.7	2.4	2.0
Chest pain or discomfort	2.0	2.9	5.5	-2.3	-1.3	-2.1	0.9	-1.4
Eye problems/disorders: Glaucoma	2.0	2.4	5.5	2.3	2.0	1.5	-0.2	-0.2
Supplements: Calcium	2.0	2.2	7.6	-1.0	1.0	-1.0	-0.5	-2.8
Average weekly spirits intake	1.9	2.3	6.3	0.5	-1.8	1.3	0.5	2.5
Number of operations (self-reported)	1.9	2.8	5.1	1.7	1.0	1.4	1.7	2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	5.7	-2.4	-1.3	-1.8	0.5	-0.9
Medication: Ramipril	1.8	2.4	5.6	-2.4	-1.1	-1.5	-0.3	-1.6
Depression (self-reported)	1.8	2.1	6.0	1.2	1.1	1.2	0.6	2.5
Ulcerative Colitis	1.7	2.5	6.1	-1.6	-2.5	-1.9	0.3	-0.2
Osteoporosis (self-reported)	1.7	2.1	7.3	1.5	2.7	0.3	1.0	-0.1
Mean Putamen Volume	1.6	1.8	3.1	-1.2	-1.8	-0.8	-1.2	-1.6
Rheumatoid Arthritis	1.6	2.2	5.4	1.3	0.4	1.7	2.3	1.1
Father’s age at death	1.6	2.2	4.2	1.6	2.0	1.4	-0.7	-1.3
Pulse wave reflection index	1.6	1.9	6.9	-0.2	0.4	-0.5	-1.5	-2.6
Overall health rating	1.6	3.4	10.0	-1.8	-0.1	-1.9	-0.4	-3.2
Had major operations	1.6	1.9	4.1	1.7	2.0	1.2	-0.2	0.9
Sensitivity / hurt feelings	1.5	2.5	4.7	-2.2	-0.9	-2.0	-1.1	-1.4
Chronic bronchitis/emphysema (mother)	1.5	1.7	5.0	1.4	0.6	2.2	-0.3	1.0
Age at first live birth	1.5	2.6	4.8	-2.1	-0.6	-2.2	-0.4	-1.8
Wears glasses or contact lenses	1.5	1.7	2.6	-1.6	-1.4	-1.3	-0.7	-1.3
Depression (Nagel 2018)	1.4	2.1	4.4	-2.1	-1.2	-1.6	0.3	-1.4
Severe depression (siblings)	1.4	1.6	2.6	1.5	-1.6	1.4	-1.0	-0.1
Glaucoma (self-reported)	1.4	1.7	3.7	1.9	1.1	1.6	-0.9	-0.2
Smoking status: Previous	1.4	2.2	6.4	0.3	0.7	0.7	2.5	1.8
Loneliness, isolation	1.4	2.0	4.2	-0.7	-1.5	0.4	2.1	1.6
Ulcerative Colitis (UC)	1.3	2.5	6.1	-1.4	-2.5	-1.9	0.3	-0.5
Time employed in main current job	1.3	1.5	6.2	-0.3	1.0	-0.0	-0.1	-2.5
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.8	-1.8	-0.5	-1.1	-0.9	-2.2
Angina (self-reported)	1.3	1.7	4.5	-0.3	-1.2	0.2	2.1	1.6
Illnesses of father: Heart disease	1.3	1.8	3.9	-1.6	-0.7	-2.0	-1.2	0.5
Ever smoked	1.3	2.3	6.0	0.6	0.9	0.7	1.9	2.5
Myopia	1.3	1.9	4.8	0.4	2.1	0.3	-0.1	-2.2
Lung cancer (father)	1.2	1.4	2.0	1.4	1.1	1.3	0.9	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.6	1.9	0.3	1.8	0.2	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.7	0.5	1.3	0.5	1.9	1.1
Tinnitus: Yes, now most or all of the time	1.2	1.3	2.2	0.8	1.5	0.3	1.3	1.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.0	-1.5	-0.0	-1.7	1.2	0.7
Unable to work because of sickness or disability	1.2	1.5	4.3	0.3	0.5	0.0	2.1	1.7
Worry (Nagel 2018)	1.1	2.4	5.4	-2.1	-0.4	-2.3	-0.4	-1.4
Bipolar Disorder (2011)	1.1	1.0	4.1	0.5	2.0	0.6	0.6	-0.1
Crohns Disease (2012)	1.1	1.8	3.8	-2.0	-1.8	-1.1	0.1	-0.9
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.0	-1.7	-1.2	-1.4	-0.2	-1.0
Hair/balding pattern: Pattern 2	1.1	1.3	2.7	0.8	1.6	0.7	1.3	1.1
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.1	-1.0	-1.2	-0.4	-1.8	-0.9
Medication: Simvastatin	1.1	1.7	3.2	-1.4	0.4	-1.1	1.8	-1.4
Medication: Cholesterol lowering	1.1	1.7	2.9	0.2	1.7	0.5	1.7	-1.6
Breastfed as a baby	1.1	1.3	4.7	-0.1	0.6	-0.5	2.2	1.1
Mood swings	1.1	1.9	2.9	-1.7	-1.2	-1.5	-0.5	-1.7
Irritable Bowel Disease (IBD)	1.0	2.3	4.2	-1.6	-2.1	-2.0	0.5	-0.6
Coronary Artery Disease (CAD)	1.0	1.1	2.5	-0.2	1.6	-0.4	1.1	1.4
Schizophrenia (2014)	1.0	2.3	5.1	-1.8	-2.3	-1.5	-0.3	-0.9
Neuroticism	1.0	2.3	6.1	-2.5	-1.1	-1.6	0.3	-1.2
Angina	1.0	1.3	3.3	-0.3	-1.0	0.2	1.8	1.4
Past tobacco smoking	1.0	1.8	5.2	0.5	-0.5	-0.0	-2.3	-1.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.9	-2.0	-1.5	-1.3	-0.0	-0.1
Mouth/teeth dental problems	1.0	1.6	3.2	1.6	0.5	1.8	0.3	1.2
Neuroticism score	1.0	2.1	5.8	-2.4	-0.5	-1.9	0.0	-0.9
Happiness	1.0	1.2	3.0	-1.0	-0.5	-1.7	-0.9	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.5	0.5	-1.6	0.9	-1.2	0.3
Eye problems/disorders: Cataract	1.0	1.1	2.2	0.5	0.7	0.9	1.5	1.3
Osteoarthritis (self-reported)	1.0	1.3	3.0	-1.7	-0.4	-1.6	0.5	-0.8
Medication: Bendroflumethiazide	1.0	1.4	3.1	-0.2	-1.0	-0.3	-1.7	-1.8
Ever depressed for a whole week	1.0	1.2	1.8	-1.4	-0.8	-0.9	-1.1	-1.4
Alzheimer’s Disease (in father)	0.9	1.0	1.9	-1.1	-1.4	-1.4	-0.4	0.2
Blood Red Count	0.9	8.3	30.9	1.1	0.8	0.7	-5.6	-2.8
Medication for hormone replacement therapy	0.9	1.0	2.0	0.2	-1.1	0.8	-1.0	-1.4
Qualifications: CSEs or equivalent	0.9	1.2	3.8	-1.0	-1.9	-0.4	-0.9	-0.7
Chronic bronchitis/emphysema (father)	0.9	1.0	2.0	-1.4	0.1	-0.8	0.7	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.0	-1.3	-1.4	-1.4	0.4	1.1
Worry too long after embarrassment	0.9	1.4	3.5	-1.3	0.7	-0.9	-0.8	-1.9
Medication: Allopurinol	0.9	1.2	3.3	0.1	-0.7	-0.0	-1.5	-1.8
Alcohol intake frequency.	0.9	2.1	4.2	1.3	0.2	1.3	1.6	2.0
Number of full sisters	0.9	1.1	2.3	0.0	-1.5	0.5	1.4	0.9
Alcohol drinker status: Previous	0.9	1.0	2.7	1.3	1.6	-0.2	0.4	0.4
Bipolar Disorder or Schizophrenia	0.8	1.8	4.5	-1.5	-2.1	-1.0	-1.0	-0.5
Age at First Birth	0.8	1.1	2.4	-1.4	-1.6	0.2	-0.9	-0.6
Medication: Metformin	0.8	1.1	2.2	1.4	1.0	1.5	0.0	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.3	1.7	0.3	1.8	-1.0	-1.3
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.1	-1.8	-1.0	-1.3	-0.6	-1.6
Alcohol intake versus 10 years previously	0.8	1.2	2.4	0.7	0.0	1.2	-1.3	-1.5
Number of live births	0.8	1.2	2.7	0.5	1.3	0.4	-1.6	-1.0
Exposure to tobacco smoke at home	0.8	0.9	2.4	0.5	-0.7	0.8	1.5	0.8
Birth weight of first child	0.8	1.5	3.3	-0.8	-1.8	-1.0	-0.9	-1.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.3	0.8	-0.2	0.6	-0.9	2.1
Medication: Omeprazole	0.8	0.9	2.2	-0.6	1.5	-1.0	0.5	-0.9
Mean time to correctly identify matches	0.8	1.6	3.8	1.0	1.9	-0.1	-0.5	-1.6
Supplements: Vitamin C	0.8	1.0	1.7	-1.3	-0.7	-0.6	-0.8	-1.3
Qualifications: nursing, teaching	0.8	1.2	2.8	-1.2	0.6	-1.3	-1.7	-0.3
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.4	-1.2	-0.9	-1.0	1.2	-0.6
Commuting to job workplace: Cycle	0.8	0.9	4.3	-0.3	-0.2	-0.2	2.1	0.4
Neuroticism (Nagel 2018)	0.7	1.7	3.4	-1.8	-0.9	-1.2	0.7	-1.4
Breast Cancer	0.7	1.7	3.7	0.8	-0.1	1.3	1.9	1.5
LDL Cholesterol	0.7	1.1	2.6	-0.8	-0.2	-1.0	1.1	1.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.9	-0.6	-1.4	0.1	0.6	1.2
Current tobacco smoking	0.7	1.1	4.2	0.6	-2.1	0.8	-0.6	-0.0
Stomach or abdominal pain in last month	0.7	0.9	1.4	0.7	-1.1	0.4	1.2	1.1
Had other major operations	0.7	0.8	1.7	1.0	0.0	1.1	0.6	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.2	0.7	-0.4	1.3	-1.8	-1.5
Falls in the last year	0.7	0.9	2.3	-1.5	-1.3	-0.7	-0.1	-0.2
Hair/balding pattern: Pattern 3	0.7	1.0	1.6	1.1	1.1	1.2	-0.9	-0.4
Length of working week for main job	0.7	0.8	1.3	0.5	-0.7	1.0	0.9	1.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.0	3.0	-0.2	-0.3	0.4	-1.7	-1.4
Comparative body size at age 10	0.7	2.1	4.5	-1.2	-0.2	-1.0	-2.1	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.0	-0.4	-1.1	-0.9	-0.2	-1.4
Leg pain on walking	0.7	0.8	1.7	-1.0	0.5	-1.1	0.1	-1.3
Medication: Gliclazide	0.7	0.7	2.2	0.2	1.5	0.3	-0.3	-1.1
Smoking status: Current	0.7	1.1	4.6	0.1	-2.1	0.4	-0.8	-0.1
High cholesterol (Self-reported)	0.7	1.2	2.8	-0.4	1.5	-1.7	0.8	-0.3
Medication: Atorvastatin	0.7	0.9	2.5	-1.6	-1.2	-0.3	-0.1	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	3.4	-0.2	1.8	-0.8	0.1	-0.6
Depressed Affect (Nagel 2018)	0.6	1.4	2.1	-1.4	-1.3	-1.1	0.8	-1.1
Reaction Time	0.6	1.2	3.5	0.8	1.3	0.1	-0.5	-1.9
Fasting Glucose	0.6	0.7	1.5	-1.0	-1.2	-0.2	-1.0	0.4
Height	0.6	11.4	17.8	-3.9	-4.2	-3.8	2.1	2.2
Smoking Status	0.6	1.5	4.0	-0.3	-1.3	0.1	2.0	1.4
Lung FEV1/FVC ratio	0.6	3.2	5.4	-1.5	-2.2	-1.4	2.3	1.1
Vitamin and mineral supplements	0.6	0.8	2.7	0.4	0.3	0.6	1.6	0.8
Medication: Co-codamol	0.6	0.7	1.8	-0.1	1.0	-1.3	0.9	-0.4
Pack years adult smoking proportion	0.6	0.9	2.3	1.3	-0.2	1.5	-0.5	-0.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.9	0.6	0.2	0.3	1.4	0.9
Supplements: Glucosamine	0.6	0.7	1.5	-0.6	0.1	-0.6	-1.2	-1.2
Had menopause	0.6	0.8	1.3	1.0	1.1	1.0	0.2	0.9
Allergy	0.6	1.5	3.2	1.8	0.5	1.6	0.2	1.2
Prospective memory result	0.6	0.7	2.2	0.4	-1.5	0.6	-0.9	0.1
Illnesses of mother	0.6	0.7	2.0	-0.8	0.1	-1.0	1.4	0.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	2.0	-1.4	-0.6	-0.8	-0.8	-0.2
Birth weight	0.6	1.3	3.1	-0.7	-1.1	-1.1	-1.8	-0.6
Number of full brothers	0.6	0.7	1.3	0.3	-1.1	1.1	1.0	0.3
Shortness of breath walking on level ground	0.6	0.7	3.3	0.1	0.2	-0.6	1.8	0.0
Migraine (self-reported)	0.6	0.8	1.6	0.6	1.2	0.5	-0.6	-1.1
Medication: Seretide 50 evohaler	0.6	0.7	2.0	0.4	0.7	0.3	-0.8	-1.4
Medication: Aspirin	0.6	0.8	2.5	-0.7	0.2	-0.8	-0.5	-1.6
Illnesses of siblings: Diabetes	0.6	0.7	3.0	0.3	0.5	-0.2	1.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.0	-0.8	-2.0	-0.2	-1.1	-0.1
Back pain experienced in last month	0.6	0.9	2.0	0.8	-0.3	0.5	1.3	1.4
Medication: Lisinopril	0.6	0.8	2.3	0.8	0.1	1.5	-0.1	0.9
Schizophrenia vs Biploar Disorder	0.5	0.7	1.7	0.8	-1.3	1.0	-0.2	0.5
Major Depression (MDD)	0.5	0.6	1.2	-1.0	-1.1	-0.2	-0.7	0.2
Primary Biliary Cirrhosis	0.5	0.7	1.5	-0.8	0.0	-1.2	0.9	0.7
Respiratory disease	0.5	1.1	2.8	-1.7	0.2	-1.4	0.9	0.3
Lung FVC	0.5	2.6	6.2	0.9	1.3	1.5	-2.5	-1.5
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.0	1.0	1.4	0.1	0.5	0.3
Average weekly fortified wine intake	0.5	0.5	0.8	-0.6	0.7	-0.8	-0.6	-0.9
Maternal smoking around birth	0.5	0.7	2.7	-0.1	0.2	-0.2	0.7	1.7
Serious illness, injury or assault to yourself	0.5	0.7	1.3	-0.3	-0.9	-0.5	1.0	1.1
Hearing difficulty/problems with background noise	0.5	0.9	2.1	1.0	0.3	1.4	-0.5	-1.0
Financial difficulties in last 2 years	0.5	0.6	1.4	-1.0	-0.7	-1.2	-0.1	0.0
Pain all over the body in last month	0.5	0.6	1.3	-0.6	1.0	-1.1	0.4	-0.3
Diabetes (self-reported)	0.5	0.8	1.5	0.9	0.6	1.2	1.1	-0.1
Impedance of arm (right)	0.5	2.3	3.8	-1.9	-1.3	-1.9	-1.0	1.0
Medication: Lansoprazole	0.5	0.6	1.9	-0.3	1.4	-0.8	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.5	-1.9	-1.5	-1.1	-0.2	-1.2
Impedance of arm (left)	0.5	2.2	4.3	-1.9	-0.9	-2.1	-1.1	0.9
Tense / ‘highly strung’	0.5	0.9	2.5	-1.6	-0.2	-1.3	0.2	-0.3
Peak expiratory flow (PEF)	0.5	1.3	3.5	-1.3	-1.9	-1.0	0.3	-0.3
Headache pain in last month	0.5	0.9	1.5	-1.2	-1.2	-1.0	-0.3	-0.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.1	0.7	-0.4	1.0	1.4	1.1
High blood pressure (siblings)	0.5	0.7	1.3	-0.8	0.8	-0.6	1.2	-0.7
Neck or shoulder pain in last month	0.5	0.8	1.9	-1.4	-1.0	-0.9	0.1	0.3
Family relationship satisfaction	0.5	0.7	1.3	-0.7	-1.0	-0.5	1.1	0.5
Knee pain experienced in last month	0.5	0.8	2.1	-0.5	1.1	-0.6	-0.6	-1.5
Average weekly red wine intake	0.5	0.7	1.6	1.3	-0.4	0.7	-0.4	1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	0.9	-0.7	1.1	0.3	-0.1
Long-standing illness, disability or infirmity	0.5	0.7	2.7	0.7	-0.0	0.5	1.7	0.2
Ever had bowel cancer screening	0.5	0.6	1.4	-0.8	0.0	-0.7	1.2	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	0.8	1.0	1.2	0.4	0.1
Medication: Aspirin	0.5	0.6	1.9	-0.6	0.4	-0.7	-0.2	-1.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	1.0	0.4	1.1	0.4	-0.8
Average weekly beer plus cider intake	0.5	0.7	1.7	-0.2	1.3	-0.7	0.9	-0.5
Pack years of smoking	0.5	0.7	1.8	1.2	-0.1	1.4	0.1	-0.3
Impedance of whole body	0.5	2.4	4.4	-2.1	-0.8	-1.9	-0.4	1.8
Crohns Disease (2017)	0.4	0.9	1.7	-1.3	-0.8	-1.3	0.6	-0.5
Prostate Cancer	0.4	0.6	1.2	0.9	-0.0	1.0	-1.1	0.5
Neuroticism (2016)	0.4	0.6	1.6	-0.7	0.3	-0.6	1.3	0.7
Allergy or Eczema	0.4	1.0	2.4	-1.6	-1.4	-0.8	0.1	-0.3
Number of treatments/medications taken	0.4	0.8	2.5	-0.1	1.6	0.2	1.1	-0.2
Impedance of leg (right)	0.4	1.9	3.3	-1.8	-1.1	-1.5	-0.5	1.5
High blood pressure (mother)	0.4	0.5	1.1	0.4	0.1	0.8	-1.0	-0.8
Impedance of leg (left)	0.4	1.7	4.4	-1.6	-0.7	-1.1	0.3	2.1
Alcohol usually taken with meals	0.4	0.7	2.7	0.1	0.2	-0.7	0.4	1.6
Illnesses of siblings	0.4	0.5	1.4	0.4	0.0	0.2	-1.2	1.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.1	-1.4	-1.3	-0.9	-1.1	-1.2
Noisy workplace	0.4	0.6	2.4	0.0	0.5	0.4	0.1	1.5
Hair/balding pattern: Pattern 4	0.4	1.0	1.5	-1.2	-1.2	-1.0	-0.7	-0.8
Forced vital capacity (FVC), Best measure	0.4	1.3	3.0	-1.7	-1.1	-0.7	-0.8	-1.0
Exposure to tobacco smoke outside home	0.4	0.5	1.2	-0.8	-0.1	-0.1	-1.1	-0.9
Number of children fathered	0.4	0.5	1.8	0.7	-0.3	1.3	0.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.9	-0.5	-0.6	0.2	-1.4	-0.1
Emphysema/chronic bronchitis	0.4	0.4	1.3	0.6	0.2	-0.3	1.1	0.6
Medication: Blood pressure	0.4	0.7	2.4	-0.3	-0.1	-0.1	1.0	-1.5
Heart disease (mother)	0.4	0.5	1.6	1.3	-0.3	0.7	-0.3	0.6
Pulse rate, automated reading	0.4	1.4	3.1	-0.6	0.6	-1.8	1.4	-1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.4	0.6	-0.0	0.5	1.2	0.3
Mineral and other dietary supplements	0.4	0.6	1.6	0.1	-0.3	0.3	1.3	1.0
Number of self-reported non-cancer illnesses	0.4	0.7	2.4	0.2	1.5	-0.2	1.0	-0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.8	0.1	-0.2	0.2	-1.3	-0.8
Illnesses of father: High blood pressure	0.4	0.5	1.6	0.9	0.4	1.3	-0.1	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	1.2	0.8	0.7	1.1	0.1	0.6
Cholesterol lowering medication	0.4	0.6	1.3	-0.8	0.3	0.3	1.0	1.2
Pain experienced in last month	0.4	0.7	1.0	1.0	0.9	1.0	-0.8	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.8	0.3	0.4	0.9	-0.9	0.3
Blood Eosinophil Count	0.3	2.1	3.8	-0.9	2.0	-1.5	1.3	-1.3
Hypothyroidism (self reported)	0.3	0.7	1.3	0.4	-0.6	1.0	1.1	0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.2	0.6	-0.1	1.1	0.7	-0.9
Chronotype (morning person)	0.3	0.6	2.8	-0.2	-0.5	-0.0	-0.1	1.7
Hand grip strength (left)	0.3	0.7	2.9	-0.5	-1.7	0.2	0.1	0.7
Hearing difficulty/problems: Yes	0.3	0.5	2.3	0.6	0.1	1.5	-0.1	0.2
Relative age of first facial hair	0.3	0.7	1.9	-0.3	-0.5	-0.4	1.0	1.4
Systolic blood pressure, automated reading	0.3	0.8	1.6	0.7	1.3	-0.5	-1.0	-0.7
Hand grip strength (right)	0.3	0.8	2.6	-1.0	-1.6	-0.7	-0.0	0.0
Townsend deprivation index at recruitment	0.3	0.4	0.9	0.1	-0.4	0.8	0.5	0.9
Fed-up feelings	0.3	0.6	1.4	-1.2	-0.7	-0.6	0.2	-0.8
Taking other prescription medications	0.3	0.4	0.7	0.5	0.8	0.5	0.7	0.6
Age when periods started (menarche)	0.3	0.8	1.6	-0.6	-0.5	-1.3	-1.3	-0.1
Medication: Atenolol	0.3	0.3	1.3	-1.1	-0.3	-0.1	0.2	-0.5
Body mass index (BMI)	0.3	1.1	4.4	0.5	0.8	0.2	-0.1	-2.1
Nervous feelings	0.3	0.6	1.5	-0.8	1.2	-0.7	-0.3	-0.3
Forced vital capacity (FVC)	0.3	1.1	2.4	-1.0	-0.8	-0.4	-1.5	-1.1
Heart attack	0.3	0.4	1.3	-0.1	0.3	1.1	0.8	0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.9	0.1	0.1	-1.0	-0.4	-0.8
Arm fat percentage (right)	0.3	1.4	4.2	-0.7	-0.1	-1.1	-1.0	-2.1
Pulse rate	0.3	0.5	1.0	-0.5	-1.0	0.1	0.7	-0.9
Asthma	0.3	0.5	1.3	-1.1	0.1	-1.1	-0.3	-0.0
Standing height	0.3	3.5	7.7	-2.3	-2.8	-1.9	0.1	0.9
Blood clot in the leg (DVT)	0.3	0.4	1.3	-0.3	0.0	-1.1	0.7	-0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	-0.3	0.6	-1.1	0.4	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	0.2	0.7	0.4	0.9	0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.6	0.1	-0.9	0.2	-0.1	1.3
Suffer from ‘nerves’	0.3	0.4	1.3	-1.2	-0.0	-0.9	0.1	-0.1
Age at last live birth	0.3	0.4	0.8	-0.8	-0.1	-0.6	-0.5	-0.9
Arm fat percentage (left)	0.3	1.2	4.1	-0.6	0.2	-1.0	-0.8	-2.0
Diabetes diagnosed by doctor	0.3	0.5	0.7	0.6	0.9	0.9	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.9	0.2	0.7	0.8	-0.4	-1.4
Average weekly champagne plus white wine intake	0.3	0.4	1.6	0.5	1.3	0.2	-0.1	0.4
Mother’s age at death	0.3	0.4	1.0	0.2	0.3	1.0	-0.8	0.0
Financial situation satisfaction	0.3	0.4	0.9	-0.6	1.0	-0.6	-0.4	-0.1
Medication: Blood pressure	0.3	0.6	1.1	0.9	1.0	0.9	-0.4	0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	-0.3	0.0	0.9	0.9	0.5
Heart disease (siblings)	0.3	0.4	1.2	-0.3	0.2	-0.7	0.4	-1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	-1.0	-0.9	-0.7	-0.4	-0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.4	-0.3	0.7	0.3	0.8
HDL Cholesterol	0.2	0.4	0.8	0.8	0.3	0.5	-0.1	0.9
Lupus	0.2	0.2	0.7	-0.1	-0.4	0.1	0.9	0.5
Triglycerides	0.2	0.3	0.6	-0.7	-0.0	-0.7	-0.0	-0.7
Blood White Count	0.2	1.2	4.5	0.4	1.1	-0.4	-0.4	-2.1
Hair Pigment	0.2	4.9	10.1	2.0	-0.1	2.0	2.5	3.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.9	0.1	-0.1	-0.2	-1.0	-0.3
Diabetes (father)	0.2	0.3	0.4	-0.4	-0.6	-0.7	-0.5	-0.3
Trunk fat percentage	0.2	1.0	1.7	-1.0	-0.1	-1.3	-0.7	-1.3
Relative age voice broke	0.2	0.3	0.8	-0.9	-0.9	0.0	-0.3	-0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.4	-0.7	0.3	0.5	-0.2
Trunk fat mass	0.2	1.0	2.6	-0.9	-0.3	-1.2	-0.6	-1.6
Waist circumference	0.2	0.8	3.0	-0.3	0.7	-0.6	0.1	-1.7
Number of incorrect matches in round	0.2	0.4	0.6	0.6	0.8	0.6	-0.2	0.6
Fluid intelligence score	0.2	0.4	0.7	-0.9	-0.3	-0.4	0.8	-0.4
Hip circumference	0.2	0.8	3.3	-0.4	0.0	-0.5	-0.4	-1.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.5	-0.3	-0.2	-0.4	-1.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.5	0.8	-0.0	0.1	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.4	0.7	0.9	0.4	0.7	0.7	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.4	-0.4	-0.8	0.0	0.0
Arm fat mass (right)	0.2	1.0	3.5	-0.4	-0.4	-0.8	-0.6	-1.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	0.0	0.8	-0.1	-0.5	0.3
Loud music exposure frequency	0.2	0.2	0.4	0.6	-0.1	0.5	-0.3	0.5
Gout (self-reported)	0.2	0.3	0.5	0.4	0.5	0.0	-0.7	-0.6
Medication: Amlodipine	0.2	0.3	0.6	-0.7	0.4	-0.6	-0.3	-0.1
Body fat percentage	0.2	0.8	2.2	-0.7	0.1	-0.9	-0.5	-1.5
Leg fat percentage (right)	0.2	0.6	2.0	0.4	0.5	0.3	-0.6	-1.4
Health satisfaction	0.2	0.2	0.5	-0.6	0.2	-0.5	0.1	-0.7
Qualifications: College or University degree	0.2	0.7	1.5	-0.5	-0.8	-1.1	-0.2	1.2
Whole body fat mass	0.2	0.8	2.3	-0.7	-0.3	-1.1	-0.0	-1.5
Comparative height size at age 10	0.2	1.0	3.8	-0.9	-1.9	-0.7	0.4	0.1
Friendships satisfaction	0.2	0.3	1.1	-0.2	0.4	-0.3	1.0	0.1
Medication for cholesterol	0.2	0.2	0.6	-0.2	0.2	-0.8	0.7	0.2
Breast cancer (self-reported)	0.2	0.2	0.5	-0.1	0.6	-0.1	0.3	-0.7
Asthma (self-reported)	0.2	0.5	1.3	-1.1	0.2	-1.1	-0.1	0.1
Arm fat mass (left)	0.2	1.0	3.5	-0.6	-0.3	-0.9	-0.4	-1.9
Miserableness	0.2	0.3	0.7	-0.6	-0.4	-0.1	0.3	-0.9
Commuting to job workplace: Public transport	0.2	0.2	0.3	-0.2	0.5	-0.6	-0.4	-0.5
Medication: Paracetamol	0.2	0.2	0.5	-0.7	-0.6	-0.4	-0.3	-0.2
Irritability	0.2	0.3	0.6	-0.5	-0.7	0.1	0.1	-0.8
Diastolic blood pressure, automated reading	0.2	0.5	1.6	0.9	-0.1	0.0	-1.2	-0.2
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	-0.6	-0.5	-0.3	0.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.9	0.0	0.1	-1.0	0.8	-0.0
Bipolar Disorder (2018)	0.1	0.2	0.9	0.2	1.0	0.1	0.1	0.0
HbA1C	0.1	0.2	0.6	0.2	0.8	-0.3	-0.1	-0.1
Blood Platelet Count	0.1	0.9	1.7	1.0	1.1	0.6	0.4	1.3
BMI	0.1	0.4	0.8	0.4	0.4	0.5	0.8	-0.9
Waist Hip Ratio (WHR)	0.1	0.5	1.2	-0.7	0.1	-1.1	0.5	-0.5
Tanning	0.1	1.1	1.9	-1.2	-1.2	-0.8	1.4	0.3
Diabetes (mother)	0.1	0.1	0.2	-0.1	0.5	-0.4	0.1	-0.2
Leg fat-free mass (left)	0.1	0.5	1.7	-0.3	-0.6	-0.4	-0.0	-1.3
High blood pressure	0.1	0.4	1.0	0.6	-0.4	1.0	0.6	0.3
Multivitamins +/- minerals	0.1	0.1	0.3	-0.3	-0.5	-0.4	-0.2	0.3
Sitting height	0.1	1.1	1.7	-1.1	-1.3	-0.9	0.3	1.2
Leg predicted mass (left)	0.1	0.5	1.8	-0.3	-0.6	-0.3	-0.1	-1.3
Qualifications: None of the above	0.1	0.2	0.4	-0.2	-0.0	0.2	0.5	0.6
Weight	0.1	0.7	2.6	-0.5	-0.5	-0.5	-0.1	-1.6
Trunk fat-free mass	0.1	0.7	2.6	-0.0	-0.9	-0.1	-0.5	-1.6
Worrier / anxious feelings	0.1	0.2	0.7	-0.8	0.3	-0.3	-0.3	-0.3
Trunk predicted mass	0.1	0.7	2.6	-0.1	-0.9	-0.1	-0.5	-1.6
Medication: Paracetamol	0.1	0.2	0.4	-0.6	-0.6	-0.3	0.3	-0.2
Arm fat-free mass (right)	0.1	0.5	2.0	-0.3	-0.5	-0.2	0.1	-1.4
Leg fat mass (right)	0.1	0.5	2.6	-0.1	-0.0	-0.3	-0.2	-1.6
Arm predicted mass (right)	0.1	0.6	2.3	-0.3	-0.6	-0.1	0.1	-1.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	-0.1	-0.2	0.4	-0.7	-0.2
Hypertension (Self-reported)	0.1	0.3	0.9	0.5	-0.4	0.9	0.0	-0.3
Whole body fat-free mass	0.1	0.6	2.2	-0.2	-0.9	-0.2	-0.2	-1.5
Leg fat-free mass (right)	0.1	0.3	1.0	-0.2	-0.5	-0.2	0.5	-1.0
Whole body water mass	0.1	0.6	2.2	-0.3	-0.8	-0.3	-0.1	-1.5
Leg predicted mass (right)	0.1	0.3	0.9	-0.2	-0.6	-0.1	0.4	-0.9
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.4	-0.1	-0.1	-0.4	0.3
Hearing aid user	0.1	0.1	0.2	0.2	0.1	0.3	0.0	-0.4
Basal metabolic rate	0.1	0.6	2.2	-0.3	-0.8	-0.3	-0.1	-1.5
Leg fat percentage (left)	0.1	0.4	1.1	0.4	0.7	0.4	-0.0	-1.0
Arm fat-free mass (left)	0.1	0.5	2.2	-0.1	-0.6	0.0	0.1	-1.5
Risk taking	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.2	0.1
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.8	-0.3	0.9	-0.8	-0.6	-0.3
Leg fat mass (left)	0.1	0.4	2.1	-0.1	0.1	-0.2	0.1	-1.5
Arm predicted mass (left)	0.1	0.6	2.2	-0.4	-0.9	-0.2	-0.1	-1.5
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.3	-0.6	0.1	-0.1	0.4	0.2
Heel T-Score	0.0	0.3	1.1	-0.0	-0.6	1.0	-0.3	0.0
Systolic Blood Pressure	0.0	0.2	0.4	0.6	0.1	-0.6	-0.2	0.4
Cardiovascular Disease	0.0	0.1	0.2	-0.0	-0.2	-0.4	0.5	0.3
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.2	0.2	-0.0	-0.2	0.2	-0.4
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.1	0.2	-0.1	0.1	0.1
Medication: Ibuprofen	0.0	0.0	0.1	-0.0	0.1	-0.2	0.2	0.4

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