TWAS hub - ARCN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.2770	0.1110	4.5e-03	-0.004	NA	-0.012	NA	-0.008	4.3e-01	NA	9.5e-01	NA	5.6e-01
2	GTEx	Skin Sun Exposed Lower leg	0.1480	0.0530	6.1e-05	0.036	NA	0.063	NA	0.025	5.8e-04	NA	6.2e-06	NA	3.7e-03
3	YFS	Blood	0.0639	0.0164	2.6e-15	0.065	0.056	0.054	0.064	0.063	2.6e-20	9.1e-18	2.6e-17	3.4e-20	9.7e-20

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Alzheimer’s Disease (in father)	6.5	7.0	10.7	3.0	1.1	3.3
LDL Cholesterol	5.7	9.0	14.2	-3.5	-0.6	-3.8
Medication: Allopurinol	5.6	7.4	11.9	2.3	3.5	2.3
Respiratory disease	4.5	10.1	19.8	-4.4	-1.6	-2.8
Hearing difficulty/problems: Yes	4.4	6.7	11.3	-3.4	-1.1	-2.7
Friendships satisfaction	4.1	5.1	7.1	-1.9	-2.7	-2.2
Primary Biliary Cirrhosis	4.0	5.7	7.4	-2.7	-2.1	-2.3
Ever smoked	4.0	7.1	9.1	-3.0	-1.7	-3.0
Arm fat mass (right)	3.9	16.0	26.1	3.9	5.1	2.6
Past tobacco smoking	3.8	7.0	10.6	2.9	1.5	3.3
Diabetes (mother)	3.7	4.7	5.2	2.1	2.3	2.1
Body mass index (BMI)	3.6	15.3	26.5	3.7	5.2	2.4
Arm fat percentage (right)	3.6	14.2	24.6	3.5	5.0	2.4
Arm fat mass (left)	3.6	14.6	23.2	3.8	4.8	2.5
Body fat percentage	3.4	13.4	20.9	3.6	4.6	2.6
Hearing aid user	3.4	3.8	6.9	-2.6	-0.8	-2.0
Ever had hysterectomy (womb removed)	3.3	3.8	5.6	1.5	1.9	2.4
High blood pressure (siblings)	3.3	4.7	7.7	-2.8	-0.1	-2.5
Worry too long after embarrassment	3.3	5.5	9.7	-3.1	-1.9	-1.8
Smoking status: Previous	3.3	4.9	7.3	-2.4	-1.4	-2.7
Trunk fat percentage	3.2	12.8	20.3	3.5	4.5	2.4
Waist circumference	3.2	11.8	16.9	3.4	4.1	2.6
Mouth/teeth dental problems: Loose teeth	3.2	3.9	4.8	-2.2	-2.1	-1.6
Leg fat mass (left)	3.2	12.3	18.1	3.6	4.2	2.4
Had other major operations	3.1	3.7	5.8	-2.4	-0.1	-2.3
Leg fat mass (right)	3.1	12.0	17.8	3.5	4.2	2.4
Arm fat percentage (left)	3.1	12.4	20.6	3.4	4.5	2.3
Leg fat percentage (left)	3.1	11.1	18.1	3.1	4.3	2.4
Whole body fat mass	3.0	12.4	18.7	3.6	4.3	2.3
Wears glasses or contact lenses	3.0	3.5	5.0	-1.8	-2.2	-1.5
Body Mass Index (BMI) (2010)	2.9	3.9	5.1	2.2	2.2	1.4
Asthma (self-reported)	2.9	5.7	10.3	-3.2	-1.5	-2.1
Trunk fat mass	2.8	12.1	18.6	3.5	4.3	2.3
Leg fat percentage (right)	2.8	10.1	17.7	2.8	4.2	2.1
Risk taking	2.7	4.0	6.8	-1.9	1.2	-2.6
Illnesses of siblings	2.6	3.6	6.0	2.5	0.2	2.2
Alzheimer’s Disease (including proxy)	2.5	3.6	5.2	2.3	0.9	2.2
Rheumatoid Arthritis	2.5	3.5	8.8	-1.1	-3.0	-0.5
Medication: Atenolol	2.5	3.1	4.8	1.1	1.8	2.2
Happiness	2.5	3.0	4.2	-1.9	-1.2	-2.0
Relative age of first facial hair	2.4	4.9	6.2	-2.5	-2.4	-1.7
Medication: Cholesterol lowering	2.4	3.8	6.1	-2.1	-0.9	-2.5
Illnesses of father: None of the above (group 1)	2.4	3.0	5.2	-1.6	-2.3	-1.0
Qualifications: O levels/GCSEs or equivalent	2.3	3.6	5.0	-2.2	-1.7	-1.7
Number of full sisters	2.3	2.8	3.9	-1.6	-1.3	-2.0
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	6.2	0.5	2.5	1.4
Asthma	2.2	4.4	8.1	-2.9	-1.3	-1.9
Knee pain experienced in last month	2.2	3.5	4.0	1.9	1.7	2.0
Diabetes (father)	2.1	2.6	4.0	2.0	1.1	1.6
Allergy	2.1	4.8	9.5	3.1	1.7	1.4
Mouth/teeth dental problems: Bleeding gums	2.1	2.7	3.9	-2.0	-1.3	-1.6
Medication: Omeprazole	2.1	2.6	5.0	1.6	0.3	2.2
Sensitivity / hurt feelings	2.0	3.5	6.7	-2.6	-1.5	-1.2
Vitamin and mineral supplements	2.0	2.7	4.5	1.3	2.1	1.4
Townsend deprivation index at recruitment	2.0	2.8	4.9	1.6	0.8	2.2
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.7	6.3	2.5	1.9	2.0
Weight	2.0	9.8	15.1	3.3	3.9	1.8
High cholesterol (Self-reported)	2.0	3.5	5.4	-2.1	-0.8	-2.3
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	4.3	1.7	0.1	2.1
Financial difficulties in last 2 years	1.8	2.4	3.7	-1.5	-1.9	-1.1
Hip circumference	1.8	7.7	12.2	2.9	3.5	1.6
Financial situation satisfaction	1.8	2.2	3.2	-1.4	-1.2	-1.8
Schizophrenia (2018)	1.7	3.6	7.7	-2.8	-0.8	-1.5
BMI	1.7	9.7	16.0	3.2	4.0	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	4.7	1.6	1.8	2.2
Bipolar Disorder or Schizophrenia	1.6	3.8	7.4	-2.7	-1.1	-1.7
Allergy or Eczema	1.6	4.3	9.2	-3.0	-1.3	-1.4
Chronic bronchitis/emphysema (father)	1.6	1.9	2.6	1.5	1.0	1.6
Had menopause	1.6	2.1	3.9	-2.0	-1.3	-0.8
Blood clot in the leg (DVT)	1.6	2.0	5.2	0.0	2.3	0.9
Family relationship satisfaction	1.6	2.0	3.1	-1.1	-1.8	-1.3
Fed-up feelings	1.5	2.8	5.6	1.1	2.4	1.2
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.0	-2.5	-1.7	-0.8
Mouth/teeth dental problems	1.5	2.3	3.1	1.3	1.5	1.8
Noisy workplace	1.5	1.9	4.3	0.9	2.1	0.7
Unable to work because of sickness or disability	1.5	1.9	4.5	0.9	2.1	0.7
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	4.7	0.1	2.2	1.0
HbA1C	1.4	1.6	4.6	-0.3	2.1	0.2
Schizophrenia (2014)	1.4	3.2	6.9	-2.6	-0.0	-1.6
Coronary Artery Disease (CAD)	1.3	1.5	2.0	1.4	1.4	0.9
Hair/balding pattern: Pattern 2	1.3	1.6	2.6	-1.5	0.1	-1.6
Qualifications: nursing, teaching	1.3	2.0	3.8	-1.2	-2.0	-0.9
Prostate Cancer	1.2	1.7	3.9	-0.9	0.6	-2.0
Smoking Status	1.2	2.9	6.2	-1.4	-0.6	-2.5
Supplements: Zinc	1.2	1.3	1.7	-1.0	-1.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	4.2	2.0	1.6	1.2
Serious illness, injury or assault to yourself	1.2	1.5	2.9	-1.2	0.0	-1.7
Father’s age at death	1.2	1.6	2.6	1.5	0.1	1.6
Illnesses of father: Heart disease	1.2	1.7	4.8	0.0	2.2	-0.5
Average weekly champagne plus white wine intake	1.2	1.7	2.1	1.3	1.4	1.1
Cardiovascular Disease	1.1	3.8	5.5	-2.4	-1.0	-2.2
Medication: Co-codamol	1.1	1.2	1.9	1.4	0.3	1.3
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.7	0.8	1.7	0.8
Falls in the last year	1.1	1.4	3.0	0.8	0.8	1.7
Medication: Amlodipine	1.1	1.6	3.0	-1.3	-1.7	-0.2
Mother’s age at death	1.1	1.3	2.0	-1.4	-1.4	-0.3
Hand grip strength (right)	1.0	2.7	3.6	-1.9	-1.4	-1.6
Average weekly fortified wine intake	1.0	1.2	2.3	-1.5	-0.0	-1.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	1.4	1.2	0.9	1.2
Gout (self-reported)	1.0	1.4	4.2	-0.0	2.1	0.2
Comparative body size at age 10	1.0	2.8	8.2	0.4	2.9	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.2	1.2	0.1	1.5
Ever taken oral contraceptive pill	1.0	1.1	2.3	-0.8	-1.5	-0.7
Leg fat-free mass (left)	0.9	4.7	8.0	2.8	2.1	1.3
Maternal smoking around birth	0.9	1.3	2.2	-1.2	0.4	-1.5
Multivitamins +/- minerals	0.9	1.1	2.8	-0.6	-1.7	-0.6
Stomach or abdominal pain in last month	0.9	1.1	1.8	1.4	0.8	0.8
Leg predicted mass (left)	0.9	4.8	8.2	2.9	2.1	1.4
Qualifications: A levels/AS levels or equivalent	0.9	2.0	2.2	-1.5	-1.4	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	3.3	-0.8	-1.8	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.0	1.4	0.8	0.8
Leg fat-free mass (right)	0.9	4.6	8.2	2.9	1.9	1.4
Mood swings	0.9	1.5	1.8	1.2	1.2	1.3
Breast cancer (self-reported)	0.9	1.1	1.7	-1.3	-0.9	-0.9
Leg predicted mass (right)	0.9	4.6	8.2	2.9	1.9	1.4
Basal metabolic rate	0.9	5.1	8.1	2.9	2.3	1.4
Arm fat-free mass (left)	0.9	4.7	6.5	2.5	2.3	1.6
Arm predicted mass (left)	0.9	4.4	6.1	2.5	2.3	1.4
Lupus	0.8	1.2	3.4	-0.2	-1.8	-0.3
Number of live births	0.8	1.1	2.1	-1.1	0.3	-1.5
Exposure to tobacco smoke outside home	0.8	1.1	1.5	1.2	1.2	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.5	-0.7	-1.2	-1.0
Pulse rate, automated reading	0.8	2.4	4.0	1.1	2.0	1.4
Leg pain on walking	0.8	1.0	2.5	0.5	0.6	1.6
Commuting to job workplace: Public transport	0.8	0.9	2.0	0.9	0.3	1.4
Eye problems/disorders: Glaucoma	0.8	1.0	1.9	0.7	1.4	0.6
Average weekly beer plus cider intake	0.8	1.2	2.9	0.7	1.7	0.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.0	-0.6	-1.0	-0.9
Medication for hormone replacement therapy	0.7	0.7	1.7	-1.3	0.4	-0.6
Medication: Metformin	0.7	1.0	1.3	-1.0	-1.1	-0.9
Relative age voice broke	0.7	1.1	1.3	-1.1	-1.1	-0.9
Medication: Ramipril	0.7	0.9	1.3	-0.5	1.1	-1.0
Medication: Simvastatin	0.7	1.0	1.8	-1.3	-0.0	-1.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	3.9	1.6	2.0	1.1
Mouth/teeth dental problems: Dentures	0.7	1.1	2.2	-0.6	-1.5	-0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.6	1.2	-0.6	1.3
Glaucoma (self-reported)	0.7	0.8	1.0	0.7	1.0	1.0
Migraine (self-reported)	0.7	0.8	1.3	-1.1	-1.0	-0.5
Medication: Seretide 50 evohaler	0.7	0.8	1.6	-0.5	1.2	-0.9
Age at last live birth	0.7	1.0	1.9	-1.4	-0.9	-0.7
Supplements: Vitamin C	0.7	0.8	1.2	-1.1	-0.4	-1.1
Triglycerides	0.6	1.0	1.3	-0.8	1.0	-1.1
Heel T-Score	0.6	4.7	8.1	-2.9	-0.7	-2.3
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.4	-1.1	-0.0	-1.5
Hand grip strength (left)	0.6	1.5	2.1	-1.2	-1.5	-0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.1	-1.4	-0.3	-0.4
Severe depression (siblings)	0.6	0.7	2.0	0.2	1.4	0.0
Supplements: Glucosamine	0.6	0.7	1.6	0.5	1.2	0.7
Illnesses of mother	0.6	0.7	1.4	0.8	0.4	1.2
Qualifications: College or University degree	0.6	1.8	2.8	-1.2	-1.7	-1.0
Angina (self-reported)	0.6	0.8	1.0	0.9	0.7	1.0
Arm predicted mass (right)	0.6	3.3	5.4	2.3	1.7	1.2
Alcohol intake frequency.	0.6	1.4	2.3	1.5	0.7	1.1
Average weekly red wine intake	0.6	0.8	1.0	-0.8	1.0	-1.0
Back pain experienced in last month	0.6	0.8	1.2	-1.1	-0.5	-1.0
Mineral and other dietary supplements	0.6	0.8	1.3	1.1	-0.2	1.1
Medication: Gliclazide	0.6	0.7	1.6	-0.6	-1.3	0.1
Whole body water mass	0.6	3.4	5.9	2.4	1.7	1.2
Number of self-reported non-cancer illnesses	0.6	1.0	1.8	-1.3	1.0	-0.1
Medication: Paracetamol	0.6	0.9	2.7	-0.2	1.7	-0.2
Worry (Nagel 2018)	0.5	1.0	2.4	-0.7	-1.6	-0.0
Ulcerative Colitis (UC)	0.5	1.0	1.8	1.0	1.3	0.5
Breast Cancer	0.5	1.1	1.6	1.3	1.1	0.8
Ovarian Cancer	0.5	0.7	1.7	0.5	1.3	0.4
HDL Cholesterol	0.5	0.8	1.4	-1.2	-0.8	-0.5
Number of incorrect matches in round	0.5	0.7	2.1	0.1	1.4	0.4
Forced vital capacity (FVC)	0.5	2.0	2.6	1.6	1.4	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.2	1.2	1.8	0.7
Impedance of arm (left)	0.5	2.3	3.7	-1.5	-1.9	-1.0
Pulse wave reflection index	0.5	0.6	1.8	0.2	-1.3	-0.2
Loud music exposure frequency	0.5	0.6	1.2	0.7	1.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.3	-1.1	0.1	-0.5
Heart disease (mother)	0.5	0.7	1.1	-1.1	0.6	-0.7
Whole body fat-free mass	0.5	3.1	5.4	2.3	1.6	1.1
Long-standing illness, disability or infirmity	0.5	0.8	1.8	-0.6	1.3	0.5
Illnesses of father: High blood pressure	0.5	0.6	1.4	0.2	1.2	0.5
Irritability	0.5	0.8	2.3	-0.2	1.5	0.3
Pain experienced in last month	0.5	0.9	1.3	-0.9	-0.7	-1.2
Supplements: Calcium	0.5	0.5	1.0	-1.0	-0.6	-0.5
Alcohol drinker status: Previous	0.5	0.6	1.2	0.3	0.6	1.1
Bipolar Disorder (2018)	0.4	0.6	0.8	-0.9	-0.6	-0.8
Age at First Birth	0.4	0.6	1.6	-0.2	-1.3	-0.3
Bipolar Disorder (2011)	0.4	0.4	1.1	0.2	1.1	0.2
Mean Putamen Volume	0.4	0.5	1.1	-0.4	-1.1	-0.4
Fasting Glucose	0.4	0.5	0.9	-0.5	1.0	-0.5
Height	0.4	6.8	9.2	-2.5	-3.0	-2.2
Waist Hip Ratio (WHR)	0.4	1.6	2.8	0.9	1.7	1.0
Lung FEV1/FVC ratio	0.4	2.2	6.2	0.7	2.5	0.0
Angina	0.4	0.6	0.7	0.8	0.6	0.8
Pack years adult smoking proportion	0.4	0.6	0.8	0.4	0.8	0.9
Medication: Levothyroxine sodium	0.4	0.7	1.5	-1.2	-0.6	-0.6
Hearing difficulty/problems with background noise	0.4	0.6	1.0	-1.0	0.1	-0.9
Time employed in main current job	0.4	0.5	0.6	-0.6	0.7	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.4	0.3	0.7	1.2
Hair/balding pattern: Pattern 3	0.4	0.5	1.6	-0.1	-1.2	-0.1
Prospective memory result	0.4	0.5	1.3	-0.5	1.1	-0.2
Trunk predicted mass	0.4	2.1	3.8	1.9	1.3	0.8
Peak expiratory flow (PEF)	0.4	0.9	2.8	0.0	1.7	-0.2
Medication: Paracetamol	0.4	0.7	1.8	-0.4	1.4	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.5	-1.2	-0.5	-0.6
Arm fat-free mass (right)	0.4	2.3	4.2	2.0	1.4	0.9
Age at first live birth	0.4	0.7	2.2	-0.0	-1.5	-0.2
Eye problems/disorders: None of the above	0.4	0.5	1.4	-0.2	-1.2	-0.0
Neck or shoulder pain in last month	0.4	0.6	1.1	1.0	0.5	0.7
Chest pain or discomfort	0.4	0.5	1.4	-0.5	-1.2	-0.2
Had major operations	0.4	0.5	1.1	-0.3	-0.5	-1.1
Medication: Aspirin	0.4	0.5	0.8	0.5	0.9	0.7
Hypertension (Self-reported)	0.4	1.2	3.1	-1.8	0.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	0.5	0.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.5	0.9	1.2	0.3
Diabetes diagnosed by doctor	0.4	0.6	1.4	-0.6	-0.1	-1.2
Osteoarthritis (self-reported)	0.4	0.6	1.4	0.2	1.2	0.5
Medication: Lisinopril	0.4	0.5	1.2	0.6	1.1	-0.1
Medication: Atorvastatin	0.4	0.5	0.7	0.6	0.6	0.9
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.3	0.0	1.1	0.2
Depressed Affect (Nagel 2018)	0.3	0.6	0.9	0.5	0.9	0.9
Irritable Bowel Disease (IBD)	0.3	0.8	1.8	0.8	1.3	0.3
Crohns Disease (2012)	0.3	0.5	1.6	0.3	1.2	-0.1
Ulcerative Colitis	0.3	0.4	1.0	0.5	1.0	0.3
Blood Platelet Count	0.3	2.9	7.8	-0.9	2.8	-0.2
Blood Red Count	0.3	2.9	7.7	0.5	2.8	0.9
Chronotype (morning person)	0.3	0.7	1.6	-0.7	-0.0	-1.2
Impedance of leg (right)	0.3	1.2	2.3	-1.5	-1.0	-0.6
High blood pressure	0.3	0.8	1.9	-1.4	0.4	-0.6
Nervous feelings	0.3	0.6	1.0	-0.9	-1.0	0.1
Diabetes (self-reported)	0.3	0.5	1.1	-0.7	0.1	-1.0
Trunk fat-free mass	0.3	1.9	3.5	1.9	1.3	0.7
Alcohol intake versus 10 years previously	0.3	0.5	1.2	0.4	-1.1	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	-0.5	0.8	-0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	0.3	-1.0	0.1
Birth weight of first child	0.3	0.5	0.8	0.9	0.7	0.5
Wheeze or whistling in the chest in last year	0.3	0.6	1.4	-1.2	-0.4	-0.3
Pulse wave peak to peak time	0.3	0.3	0.5	-0.6	0.7	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	0.8	-0.6	-0.9	0.0
Eye problems/disorders: Cataract	0.3	0.4	0.5	0.7	0.3	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	0.5	0.1	0.9
Osteoporosis (self-reported)	0.3	0.3	0.6	-0.8	0.1	-0.6
Miserableness	0.3	0.6	0.9	0.9	-0.0	0.9
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	-0.9	-0.1	-0.4
Alcohol drinker status: Never	0.3	0.3	0.5	0.7	0.7	-0.2
Age started oral contraceptive pill	0.3	0.4	0.7	-0.8	-0.7	-0.2
Ever depressed for a whole week	0.3	0.3	0.6	-0.8	-0.7	0.0
Commuting to job workplace: Cycle	0.3	0.3	0.9	0.3	-0.9	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.1	1.1	-0.9	0.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	-0.6	-0.1	-0.7
Pack years of smoking	0.3	0.4	0.8	0.2	0.7	0.9
Impedance of whole body	0.3	1.7	2.8	-1.4	-1.7	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.1	-1.1	-0.5	-0.4
Neuroticism (Nagel 2018)	0.2	0.4	0.7	-0.8	-0.8	0.1
Crohns Disease (2017)	0.2	0.4	1.2	0.4	1.1	0.1
Reaction Time	0.2	0.5	0.9	-0.9	-0.2	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.3	0.1	1.1	0.2
Blood Eosinophil Count	0.2	1.9	3.5	1.9	-0.4	1.4
Lung FVC	0.2	1.0	1.4	0.9	0.9	1.2
Number of treatments/medications taken	0.2	0.4	0.8	-0.4	0.9	0.3
Systolic blood pressure, automated reading	0.2	0.4	0.6	0.8	0.4	0.7
Current tobacco smoking	0.2	0.4	0.9	0.4	1.0	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.9	-0.1	-0.3
Taking other prescription medications	0.2	0.3	0.7	-0.9	0.4	-0.1
High blood pressure (mother)	0.2	0.2	0.3	0.4	0.5	0.6
Qualifications: None of the above	0.2	0.5	1.1	0.5	0.4	1.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.6	-0.1	0.5
Impedance of arm (right)	0.2	1.2	1.8	-1.3	-1.1	-0.6
Pulse rate	0.2	0.4	0.9	-1.0	0.4	-0.2
Depression (self-reported)	0.2	0.2	0.5	0.3	0.3	0.7
Medication: Lansoprazole	0.2	0.2	0.5	0.2	0.1	0.7
Lung cancer (father)	0.2	0.3	0.5	0.2	-0.6	0.7
Length of working week for main job	0.2	0.2	0.5	0.3	-0.0	0.7
Birth weight	0.2	0.4	0.8	0.3	-0.9	0.4
Forced vital capacity (FVC), Best measure	0.2	0.9	1.7	0.9	1.3	0.4
Number of children fathered	0.2	0.2	0.5	-0.7	-0.5	0.0
Health satisfaction	0.2	0.3	0.4	0.6	-0.3	0.6
Shortness of breath walking on level ground	0.2	0.3	0.8	-0.1	-0.9	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-0.1	-0.9	-0.5
Mean time to correctly identify matches	0.2	0.3	0.8	-0.9	-0.1	-0.3
Comparative height size at age 10	0.2	0.9	1.6	-0.6	-0.8	-1.3
Suffer from ‘nerves’	0.2	0.3	0.8	-0.9	0.2	-0.0
Ever had bowel cancer screening	0.2	0.2	0.5	0.2	0.2	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.6	-0.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-0.2	0.0	-1.0
Medication: Aspirin	0.2	0.3	0.5	0.2	0.7	0.6
Smoking status: Current	0.2	0.3	0.8	0.4	0.9	-0.3
Medication: Bendroflumethiazide	0.2	0.4	0.5	0.7	0.6	0.5
Heart disease (siblings)	0.2	0.2	0.3	0.4	0.5	0.5
Depression (Nagel 2018)	0.1	0.1	0.3	0.1	-0.0	0.5
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	-0.6	0.4	0.1
Neuroticism (2016)	0.1	0.2	0.2	-0.4	-0.5	-0.2
Blood White Count	0.1	0.6	1.3	0.3	-1.1	0.6
Systolic Blood Pressure	0.1	0.5	0.9	-0.3	-0.9	-0.8
Neuroticism	0.1	0.2	0.4	-0.7	-0.5	0.2
Tanning	0.1	1.5	2.7	-1.2	-1.6	-0.6
Average weekly spirits intake	0.1	0.1	0.3	0.0	0.5	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.1	0.5	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.3	0.0	0.3
Impedance of leg (left)	0.1	0.6	1.1	-0.9	-1.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.6	-0.0	-0.3
Heart attack	0.1	0.2	0.3	0.2	0.6	0.4
Fluid intelligence score	0.1	0.1	0.3	0.1	-0.5	-0.4
Neuroticism score	0.1	0.1	0.3	-0.5	0.1	0.2
Worrier / anxious feelings	0.1	0.2	0.5	-0.4	-0.7	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.3	0.3	0.0
Standing height	0.1	0.8	2.2	-0.1	-1.5	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.2	0.4	-0.0
Breastfed as a baby	0.1	0.1	0.2	-0.1	0.5	-0.0
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.2	-0.5	0.5	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.4	0.1	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.3	-0.4	-0.3
Number of full brothers	0.1	0.1	0.2	0.2	0.3	-0.4
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	0.3	-0.1
Medication: Blood pressure	0.1	0.2	0.3	-0.5	0.5	-0.4
Medication: Ibuprofen	0.1	0.1	0.1	-0.1	0.3	0.3
Overall health rating	0.1	0.1	0.2	0.1	0.5	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.0	-0.4	-0.4
Medication for cholesterol	0.1	0.1	0.2	0.0	-0.3	-0.4
Guilty feelings	0.1	0.2	0.3	0.6	0.4	0.1
Medication: Blood pressure	0.1	0.2	0.4	-0.2	0.3	0.6
Number of operations (self-reported)	0.1	0.2	0.3	-0.3	0.5	-0.3
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.0	0.1	0.6
Myopia	0.1	0.2	0.5	0.0	-0.7	0.1
Cholesterol lowering medication	0.1	0.1	0.3	-0.6	-0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.0	0.5	0.2
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.2	-0.1	-0.1
Major Depression (MDD)	0.0	0.0	0.0	-0.0	-0.0	-0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.1	0.1
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.4	-0.1	0.2
Hair Pigment	0.0	0.3	0.9	0.3	-0.1	-0.9
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.1	0.0	0.4
Age when periods started (menarche)	0.0	0.0	0.1	0.2	-0.1	0.3
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	0.1	-0.1	0.3
Sitting height	0.0	0.1	0.2	0.3	0.4	-0.4
Alcohol usually taken with meals	0.0	0.0	0.0	0.2	-0.2	0.0
Pain all over the body in last month	0.0	0.0	0.1	-0.1	0.2	0.2
Tense / ‘highly strung’	0.0	0.0	0.1	-0.1	-0.3	-0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.2	-0.3	0.3
Headache pain in last month	0.0	0.1	0.1	0.1	-0.3	0.3
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	0.1	-0.0	-0.1
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.0	0.1	0.3
Loneliness, isolation	0.0	0.1	0.1	-0.3	0.0	0.3
Commuting to job workplace: Walk	0.0	0.0	0.0	0.2	0.1	-0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.1	-0.3	0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	0.1	-0.2	-0.0
Diastolic blood pressure, automated reading	0.0	0.1	0.2	-0.1	0.5	-0.0

Hub : Genes

ARCN1

Models

Trait associations