Hub : Genes

ARHGAP15

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0560 0.0133 1.8e-11 0.023 0.044 0.039 0.044 0.036 5.1e-08 6.3e-14 1.0e-12 6.5e-14 8.7e-12
2 YFS Blood 0.2342 0.0328 0.0e+00 0.088 0.177 0.204 0.207 0.200 3.5e-27 1.1e-55 1.1e-64 1.2e-65 3.1e-63
3 TCGA Colon Adenocarcinoma 0.1670 0.0550 2.9e-04 0.043 0.090 0.060 NA 0.076 1.6e-03 6.7e-06 2.2e-04 NA 3.5e-05
4 TCGA Head and Neck Squamous Cell Carcinoma 0.0499 0.0207 4.6e-03 0.006 0.008 -0.002 NA -0.001 6.1e-02 4.2e-02 9.0e-01 NA 4.2e-01
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0759 0.0314 4.9e-03 0.021 0.024 0.031 NA 0.029 1.8e-03 8.7e-04 1.7e-04 NA 2.7e-04
6 TCGA Liver Hepatocellular Carcinoma 0.3000 0.0890 6.7e-04 0.009 0.029 0.063 NA 0.043 1.2e-01 1.5e-02 6.5e-04 NA 4.1e-03
7 TCGA Prostate Adenocarcinoma 0.0531 0.0229 5.0e-03 -0.002 0.007 -0.002 NA -0.001 6.6e-01 5.4e-02 7.0e-01 NA 4.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 2.1 3.4 7.4 -2.7 -1.6 -1.1 -1.4 -1.9 -0.1 -2.7
Bipolar Disorder or Schizophrenia 0.9 2.3 6.2 -2.5 -1.2 -0.8 0.6 -0.7 -1.3 -2.3
Depressed Affect (Nagel 2018) 1.5 3.2 8.3 -2.1 -1.8 -0.8 -1.6 -1.5 1.0 -2.9
Depression (Nagel 2018) 1.2 1.9 3.9 -1.7 0.0 -1.6 -1.2 -1.0 -1.0 -2.0
Intelligence (Savage-Jansen 2018) 0.2 0.5 1.0 -0.8 -0.6 -0.1 -1.0 0.9 -0.3 0.9
Neuroticism (Nagel 2018) 0.9 2.0 7.7 -1.8 -1.1 -0.8 -0.6 -1.1 -0.0 -2.8
Schizophrenia (2018) 0.5 1.1 3.6 -1.0 -0.2 -0.2 1.9 0.7 -1.4 -0.8
Schizophrenia vs Biploar Disorder 1.5 1.9 7.9 1.5 1.5 0.6 2.8 0.2 -0.7 0.5
Worry (Nagel 2018) 0.3 0.6 1.9 -0.8 0.3 -1.4 -0.0 -0.3 -0.5 -1.1
Alzheimer’s Disease (in mother) 0.2 0.3 1.0 -0.2 -0.2 1.0 0.2 0.2 -0.8 -0.5
Alzheimer’s Disease (in father) 0.8 0.8 2.5 1.1 1.0 -0.6 0.1 -0.5 0.8 1.6
Alzheimer’s Disease (including proxy) 0.4 0.6 1.1 0.6 0.8 1.0 0.9 -0.5 -0.1 1.0
Crohns Disease (2017) 3.1 6.8 17.2 4.2 3.8 -0.1 1.6 1.7 0.0 3.2
Irritable Bowel Disease (IBD) 0.7 1.6 4.4 1.8 2.1 -0.1 0.8 0.9 -0.6 1.3
Ulcerative Colitis (UC) 0.1 0.3 0.7 -0.8 -0.4 0.1 -0.1 -0.0 -0.7 -0.7
Major Depression (MDD) 1.2 1.4 3.5 -0.9 -0.7 -1.0 -1.1 -1.9 0.9 -1.5
Reaction Time 1.3 2.5 10.7 1.6 3.3 0.1 1.8 -1.1 -0.4 0.3
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.5 -0.8 -0.5 -0.6 -0.9 1.2 -0.3 0.7
Breast Cancer 1.4 3.3 7.6 -1.9 -2.1 -1.5 -2.3 -0.7 0.1 -2.8
Ovarian Cancer 0.6 0.8 2.2 -0.2 -0.6 -1.1 -1.5 -0.0 1.2 -0.3
Prostate Cancer 0.9 1.3 4.8 0.7 -0.7 1.5 0.2 2.2 -0.7 0.6
Age at First Birth 2.2 3.2 6.9 1.9 1.7 0.6 2.6 -0.5 -2.5 1.4
Bipolar Disorder (2011) 2.4 2.3 9.0 -1.8 -0.3 -1.5 -0.6 -0.8 -0.9 -3.0
Body Mass Index (BMI) (2010) 2.6 3.6 9.1 -2.6 -1.9 -1.2 -2.0 -0.7 0.2 -3.0
Coronary Artery Disease (CAD) 1.0 1.2 4.4 0.9 1.1 0.4 1.0 0.5 -2.1 0.5
Crohns Disease (2012) 2.6 4.2 12.4 3.5 2.8 -0.5 1.2 0.0 -0.2 2.8
Mean Putamen Volume 0.6 0.6 1.9 0.4 0.6 -0.9 -0.4 -0.7 -0.8 -1.4
Fasting Glucose 1.3 1.6 6.1 -2.5 -1.0 -0.3 -1.1 0.9 -0.7 -1.2
HbA1C 0.2 0.2 0.7 -0.3 0.4 0.3 -0.2 0.7 0.8 -0.1
HDL Cholesterol 0.1 0.2 0.5 0.4 0.3 0.7 0.2 -0.2 0.2 0.7
LDL Cholesterol 0.3 0.4 1.7 -0.5 -0.2 0.1 -0.3 0.0 1.0 -1.3
Lupus 1.0 1.5 3.7 -1.0 0.1 -1.4 -1.1 -1.5 1.9 -0.3
Neuroticism (2016) 0.4 0.6 1.5 -0.0 -0.6 0.2 -0.4 -0.9 1.2 -1.1
Primary Biliary Cirrhosis 0.8 1.1 3.2 0.8 1.1 -0.1 0.9 1.8 -0.9 1.1
Rheumatoid Arthritis 1.7 2.3 5.2 -1.6 -1.6 -1.7 -1.6 -0.4 -0.4 -2.3
Schizophrenia (2014) 0.9 1.9 5.2 -1.0 0.5 -0.1 2.3 0.7 -2.2 -1.3
Triglycerides 0.1 0.1 0.2 0.4 0.2 0.2 -0.4 0.4 0.1 -0.2
Type 2 Diabetes (T2D) (2012) 3.1 3.6 10.4 -1.4 -1.2 -3.2 -1.5 -1.7 -1.7 -1.8
Ulcerative Colitis 0.6 0.8 2.6 -1.0 -0.3 -0.3 -0.8 -0.5 -1.0 -1.6
Blood Eosinophil Count 0.5 3.9 11.2 0.7 3.4 2.4 1.2 -0.2 1.6 2.5
Blood Platelet Count 1.1 13.2 41.7 3.7 6.5 4.1 3.2 0.9 0.8 2.8
Blood Red Count 0.2 1.8 8.7 -0.9 -0.2 1.1 0.8 3.0 0.7 0.7
Blood White Count 3.2 24.0 85.2 6.5 9.2 4.2 3.6 1.6 -0.2 2.7
Heel T-Score 0.2 1.8 3.8 -1.7 -1.9 -1.3 -1.9 0.1 0.6 0.1
BMI 2.1 11.9 32.8 -5.5 -2.7 -0.2 -3.5 -0.2 0.5 -5.7
Height 0.4 8.6 19.4 -4.4 -2.7 -3.5 -3.2 -1.8 -1.4 -2.3
Waist Hip Ratio (WHR) 0.3 1.4 4.2 -0.3 -1.1 1.1 0.4 -0.7 2.0 1.6
Systolic Blood Pressure 0.5 2.7 12.8 1.4 -0.5 -0.9 -1.4 -3.6 0.8 0.8
Smoking Status 1.5 3.5 8.2 -2.9 -2.7 -0.5 -1.5 -0.9 1.9 -1.5
Allergy or Eczema 5.7 14.9 30.4 5.5 5.3 2.5 2.8 2.1 0.2 5.3
Cardiovascular Disease 1.7 5.6 9.9 -2.5 -2.8 -1.2 -2.9 -3.1 0.1 -2.3
Hypothyroidism (self reported) 1.0 2.4 5.8 2.3 2.4 1.5 1.0 -0.6 0.4 1.4
Respiratory disease 0.4 1.0 5.0 1.1 2.2 -0.1 0.5 0.2 -0.2 0.3
Type 2 Diabetes (T2D) (2018) 0.2 0.5 1.6 -0.5 0.4 0.8 -0.4 0.6 0.2 -1.3
Lung FEV1/FVC ratio 0.3 1.6 5.6 0.6 -0.7 -0.3 0.2 -0.9 1.9 2.4
Lung FVC 1.4 7.1 10.4 -2.6 -2.7 -2.4 -3.1 1.1 -3.2 -3.0
Neuroticism 0.4 1.1 5.5 -0.9 0.4 0.7 0.4 -0.3 0.5 -2.3
Chronotype (morning person) 1.4 3.3 9.9 -1.4 -1.2 -0.8 -2.2 -3.1 0.1 -2.2
Hair Pigment 0.0 1.3 2.6 -0.7 -1.1 1.4 1.0 1.6 0.5 1.0
Tanning 0.1 1.2 2.3 -1.1 -0.7 -0.9 -0.7 1.2 -1.5 -1.3
Hand grip strength (left) 0.2 0.5 1.2 -0.7 -0.8 -1.0 0.4 1.1 0.2 0.3
Number of treatments/medications taken 0.3 0.5 1.6 -0.4 -0.1 -0.6 -0.8 0.4 -1.3 -0.5
Average weekly spirits intake 1.0 1.2 2.6 -1.6 -1.4 -1.0 -1.0 -0.1 0.7 -1.1
Sensitivity / hurt feelings 0.2 0.4 1.0 0.8 1.0 -0.1 0.3 0.0 0.0 1.0
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.0 -0.2 0.5 -1.4 -0.4 -1.2 -1.3 -0.4
Hearing difficulty/problems: Yes 0.3 0.5 1.5 0.9 1.2 0.3 0.6 0.1 0.4 0.8
Relative age of first facial hair 0.5 1.1 4.0 -0.5 -0.9 -2.0 -1.2 -0.8 -0.1 0.9
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.7 -1.2 -0.2 -1.2 -1.1 -0.0 -0.5 -1.3
Ever used hormone-replacement therapy (HRT) 1.1 1.4 4.6 -1.0 -0.4 0.2 -1.0 -0.7 -1.6 -2.1
Ever had hysterectomy (womb removed) 0.9 1.0 2.9 0.4 0.4 -0.7 -1.3 -1.7 -0.1 -1.2
Systolic blood pressure, automated reading 0.2 0.7 1.6 1.3 0.4 0.3 -1.2 -1.0 0.0 -0.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 2.0 0.2 0.2 -0.8 -0.9 -0.5 -0.5 -1.4
Angina 0.5 0.7 1.9 1.4 0.3 0.2 0.8 1.2 -0.2 1.0
Medication for hormone replacement therapy 0.9 1.0 2.4 -0.4 1.3 1.4 1.6 0.1 -0.9 0.5
Vitamin and mineral supplements 1.1 1.5 3.3 -0.8 -1.4 1.1 -0.0 1.6 0.8 1.8
Supplements: Zinc 1.0 1.0 3.2 -1.1 0.3 -1.4 -0.6 -1.8 -0.2 -0.7
Medication: Co-codamol 0.2 0.2 1.1 -0.4 -0.0 -0.3 -0.1 0.0 0.0 1.0
Medication: Metformin 0.3 0.5 1.2 -0.3 1.1 0.4 -0.4 1.0 -0.3 -0.8
Diabetes (father) 1.3 1.6 3.6 0.7 1.7 1.1 1.9 1.0 0.1 -1.3
Diabetes (mother) 0.3 0.4 1.2 1.1 0.6 -0.5 0.1 -0.7 0.6 0.5
Severe depression (siblings) 0.6 0.7 3.3 -0.9 -0.5 -0.2 -0.7 0.0 -1.8 -0.3
Pack years adult smoking proportion 0.6 0.9 2.0 -1.0 -1.0 -1.4 0.0 -1.1 -0.1 0.9
Impedance of leg (right) 1.0 4.9 20.1 2.4 1.1 0.2 2.7 0.0 0.6 4.5
Leg fat-free mass (left) 1.9 10.3 30.2 -5.5 -2.9 -1.0 -3.2 -0.6 0.7 -4.6
Trunk fat percentage 1.2 4.7 17.8 -4.2 -2.1 0.8 -0.9 0.9 1.4 -2.6
Hand grip strength (right) 0.2 0.6 1.5 -0.5 -0.8 -1.2 0.6 -0.2 -1.0 0.7
Townsend deprivation index at recruitment 0.3 0.4 1.2 -0.0 -0.7 -1.1 -0.7 -0.7 0.2 0.4
Current tobacco smoking 0.7 1.2 4.8 -1.3 -2.2 0.1 -0.6 -1.2 0.3 -0.0
Average weekly fortified wine intake 2.4 2.8 5.7 1.8 1.6 1.3 2.2 1.2 -0.4 2.4
Maternal smoking around birth 0.2 0.3 0.7 -0.9 -0.4 -0.5 0.7 -0.2 0.6 -0.1
Fed-up feelings 0.9 1.6 6.8 -0.9 -0.8 -0.7 -1.4 -0.1 0.9 -2.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.4 -1.1 -0.0 -1.4 -1.6 -0.9 -0.4 -0.9
Relative age voice broke 1.2 1.8 7.4 -0.2 -1.4 -2.7 -1.3 -0.5 0.8 0.5
Taking other prescription medications 0.3 0.4 1.6 -0.2 0.9 -0.0 -0.1 1.3 -0.7 0.2
Age when periods started (menarche) 0.4 0.9 1.5 0.9 0.9 1.1 0.9 1.2 -0.6 0.9
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 9.0 0.2 -0.1 -2.2 -3.0 -1.9 -0.2 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 5.1 -0.7 -1.5 -0.4 -1.7 -0.1 2.2 0.1
Tinnitus: Yes, but not now, but have in the past 3.5 3.8 9.0 -0.8 -1.2 -3.0 -2.4 -3.0 -1.0 0.2
Qualifications: CSEs or equivalent 0.3 0.4 1.1 -0.5 -0.9 0.6 0.4 -0.3 -0.0 1.1
Serious illness, injury or assault to yourself 0.7 0.9 2.9 -0.3 0.5 -1.7 -0.2 -0.4 -1.5 -0.8
High blood pressure 1.1 3.1 5.7 -1.4 -1.6 -1.3 -2.4 -2.1 -0.9 -2.1
Hayfever, allergic rhinitis or eczema 5.8 12.5 30.9 5.0 5.6 1.9 2.6 0.6 -0.0 4.6
Multivitamins +/- minerals 1.6 2.0 6.1 -0.2 0.2 -1.6 -0.5 -2.5 -0.6 -2.1
Stomach or abdominal pain in last month 1.8 2.3 4.2 -0.5 -1.0 -1.9 -2.1 -2.0 0.3 -1.7
Supplements: Glucosamine 1.5 2.0 5.1 1.2 2.2 -1.1 -0.2 -0.7 -1.6 -1.7
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 3.8 0.8 0.5 -0.4 0.1 1.8 -1.9 1.9
Medication: Atenolol 1.5 1.8 3.9 -1.2 -2.0 -1.7 -1.2 0.4 -1.7 0.4
Medication: Levothyroxine sodium 0.6 1.0 3.3 0.6 1.8 0.6 1.3 -0.2 -0.9 0.0
Sitting height 0.6 4.0 11.4 -3.4 -1.5 -1.1 -2.5 -1.6 0.2 -2.1
Chronic bronchitis/emphysema (father) 1.1 1.3 5.7 -0.8 0.2 -0.5 -0.2 2.4 -1.3 -0.9
High blood pressure (mother) 1.0 1.4 5.0 0.6 0.5 -2.2 -0.9 -1.8 0.4 0.3
Body mass index (BMI) 2.3 10.0 27.7 -5.3 -3.2 -0.3 -2.6 -0.4 0.8 -5.0
Impedance of leg (left) 1.2 6.0 21.8 2.9 1.8 0.3 2.9 0.2 0.4 4.7
Leg predicted mass (left) 2.0 10.4 30.4 -5.5 -3.0 -1.1 -3.3 -0.7 0.7 -4.6
Trunk fat mass 1.7 7.2 26.2 -5.1 -2.6 0.3 -1.8 0.4 1.4 -3.5
Waist circumference 1.2 4.5 15.2 -3.9 -2.4 0.1 -1.4 -0.1 1.2 -2.6
Number of incorrect matches in round 1.0 1.6 3.7 -0.8 0.3 -1.8 -1.9 -1.1 -0.9 -1.5
Past tobacco smoking 1.2 2.3 4.6 2.1 1.4 0.6 1.5 -1.0 -2.0 1.4
Alcohol usually taken with meals 3.6 5.8 13.5 3.3 3.7 0.5 2.3 1.0 -2.5 1.8
Nervous feelings 0.2 0.3 1.5 0.6 0.5 -0.2 -0.2 0.2 1.2 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.3 3.8 -0.6 -0.2 -1.0 -0.9 0.0 -1.9 -1.9
Hearing difficulty/problems with background noise 0.5 0.8 2.7 0.7 0.7 -0.7 0.7 0.8 0.3 1.6
Hair/balding pattern: Pattern 2 2.1 2.6 11.4 -1.0 -0.4 -3.4 -0.5 -0.1 -2.3 0.7
Had menopause 0.7 0.9 2.2 1.0 0.8 0.1 0.9 0.9 -0.8 -1.5
Had other major operations 1.9 2.3 5.0 -1.7 -0.9 -0.9 -2.2 -1.4 1.1 -1.9
Forced vital capacity (FVC) 0.8 3.0 6.9 -2.6 -2.1 -1.8 -1.9 0.8 -0.3 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 5.7 -0.6 -1.1 -0.7 -1.8 -0.4 2.4 -0.3
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 4.6 -0.6 0.4 -2.1 -1.0 -1.1 -0.2 -0.2
Qualifications: None of the above 1.8 4.0 10.6 -2.3 -2.7 0.0 -1.4 -1.5 -0.2 -3.3
Financial difficulties in last 2 years 1.0 1.3 3.4 -1.1 -0.7 -1.8 -1.5 -1.0 0.4 -0.8
Mouth/teeth dental problems 1.4 2.1 7.5 2.7 0.5 0.8 0.7 -1.3 -0.3 2.0
Heart attack 0.3 0.3 1.4 0.1 -1.2 -0.0 -0.5 -0.2 -0.8 0.2
Allergy 2.9 6.6 17.7 -3.6 -4.2 -1.6 -1.4 -1.0 -0.4 -3.1
Pain all over the body in last month 0.7 0.7 1.8 -0.1 0.3 -1.4 -1.3 -1.2 -0.1 0.0
Diabetes (self-reported) 0.7 1.0 3.7 -0.9 0.0 -0.2 -1.1 1.1 0.2 -1.9
Hayfever/allergic rhinitis (self-reported) 6.2 8.3 16.6 4.1 3.7 3.0 2.0 1.1 1.7 3.2
Medication: Ramipril 0.4 0.5 1.2 0.9 -0.7 0.6 1.1 0.5 0.4 0.3
Medication: Simvastatin 0.3 0.5 1.4 -0.1 -0.8 0.7 0.4 -0.7 0.0 -1.2
Fluid intelligence score 0.1 0.3 0.9 -0.6 -0.3 0.2 -0.2 0.7 -0.4 1.0
Illnesses of siblings 0.6 0.8 2.0 0.7 1.4 1.4 0.8 0.1 0.5 0.8
Neuroticism score 0.2 0.5 2.1 -0.2 0.4 0.3 0.0 -0.1 1.0 -1.4
Weight 2.3 11.3 36.6 -6.0 -3.5 -0.6 -2.7 -0.6 1.0 -4.6
Impedance of arm (right) 1.6 7.5 28.3 2.9 2.1 1.3 2.9 0.6 1.0 5.3
Arm fat percentage (right) 1.5 5.8 21.3 -4.6 -2.8 0.2 -1.6 0.3 1.6 -2.6
Trunk fat-free mass 1.7 10.0 23.5 -4.8 -3.2 -1.8 -3.5 -1.9 0.4 -4.1
Hip circumference 0.9 4.0 16.6 -4.1 -2.1 0.1 -1.1 0.7 0.9 -2.2
Time employed in main current job 0.1 0.2 0.3 -0.5 0.5 0.3 0.2 0.2 -0.5 -0.5
Alcohol intake versus 10 years previously 0.6 0.9 2.1 0.2 -0.8 1.2 1.3 -0.1 -0.4 1.4
Father’s age at death 1.8 2.4 10.1 0.8 1.8 -1.4 0.2 0.7 -3.2 0.4
Worrier / anxious feelings 0.2 0.4 1.1 -0.9 -0.9 -1.1 0.1 0.5 -0.1 -0.1
Frequency of tiredness / lethargy in last 2 weeks 1.8 3.0 6.7 -2.0 -1.4 -2.4 -2.6 -0.8 0.3 -1.2
Falls in the last year 2.7 3.7 7.5 -2.5 -1.2 -1.9 -2.7 -1.0 -0.7 -2.4
Hair/balding pattern: Pattern 3 0.7 1.0 3.5 -0.3 -0.1 1.1 1.2 1.9 -0.5 0.8
Number of live births 0.5 0.8 1.4 0.2 -1.1 1.1 -0.2 1.2 1.0 -0.6
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 3.6 -1.9 -1.8 -1.4 -1.5 0.5 0.1 -0.2
Pulse rate 0.7 1.1 4.5 0.7 2.1 0.8 -0.4 1.2 -0.3 0.7
Happiness 1.3 1.6 3.0 1.3 1.4 1.0 1.4 -0.5 -1.1 1.7
Noisy workplace 0.3 0.4 1.1 -0.1 -0.5 1.1 -0.7 0.2 0.9 -0.5
Qualifications: A levels/AS levels or equivalent 1.4 3.1 8.3 1.7 2.4 1.1 1.2 1.0 1.0 2.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.2 -0.4 0.1 -1.1 -0.0 0.6 -0.8 0.4
Mouth/teeth dental problems: Dentures 0.6 1.0 1.8 -1.2 -1.3 -1.2 -0.3 0.7 -1.2 -0.1
Asthma 0.7 1.5 7.1 0.9 2.7 0.2 1.1 0.9 0.1 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.4 -0.5 0.1 0.5 -0.3 -0.0 0.9 -1.2
Medication: Cholesterol lowering 0.3 0.5 1.6 0.0 -0.8 0.3 0.9 0.1 -1.3 -0.3
Depression (self-reported) 0.8 1.0 2.7 0.5 1.6 0.3 0.9 1.6 -0.4 -0.7
Medication: Lansoprazole 1.0 1.2 4.6 0.4 0.7 0.6 0.4 2.1 -1.1 -1.1
Prospective memory result 1.7 2.1 4.6 1.7 1.3 2.2 1.9 0.6 0.1 1.4
Lung cancer (father) 0.3 0.3 1.4 -0.1 0.5 -0.3 0.8 0.2 -1.2 -0.2
Illnesses of mother 1.1 1.4 3.7 -0.9 -0.0 1.9 1.0 1.9 0.5 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 3.4 -1.8 -1.6 -1.6 -1.9 -0.3 0.6 -1.1
Pulse wave Arterial Stiffness index 0.3 0.4 1.5 -0.8 -1.2 0.0 -0.3 0.0 0.5 0.4
Impedance of arm (left) 1.8 8.1 25.2 3.0 2.1 1.8 3.3 1.6 0.9 5.0
Arm fat mass (right) 2.2 9.1 30.2 -5.5 -3.4 -0.1 -2.4 -0.4 1.6 -3.8
Trunk predicted mass 1.7 9.7 22.5 -4.7 -3.2 -1.9 -3.5 -1.9 0.3 -4.0
Standing height 0.1 1.5 6.5 -2.5 -1.4 -0.9 -0.7 -0.7 0.4 -0.2
Length of working week for main job 3.5 3.9 11.8 -0.9 -1.1 -2.1 -2.2 -3.4 -1.4 -1.4
Exposure to tobacco smoke at home 1.4 1.6 5.2 -0.9 -2.3 -0.9 -0.9 -1.9 0.0 -0.1
Breastfed as a baby 2.0 2.4 6.1 0.4 2.5 0.6 1.7 1.5 -2.3 -0.3
Tense / ‘highly strung’ 0.3 0.5 1.4 0.9 0.7 -0.2 0.2 -0.6 -1.2 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 3.7 -1.6 -0.6 -1.6 -1.5 0.0 0.1 -1.9
Hair/balding pattern: Pattern 4 1.4 3.3 7.4 1.6 0.0 2.7 2.2 1.9 1.5 1.6
Birth weight of first child 0.2 0.4 1.2 -0.7 -1.0 -1.1 0.2 0.4 0.4 0.1
Peak expiratory flow (PEF) 1.6 3.7 7.5 -2.6 -2.7 -2.2 -2.1 -0.5 1.6 0.4
Pulse wave reflection index 0.9 1.1 4.0 -0.8 -2.0 -0.6 0.1 -1.3 0.4 0.9
Ever highly irritable/argumentative for 2 days 2.0 2.4 5.8 -1.4 -1.8 -1.3 -1.8 -0.9 -0.7 -2.4
Loud music exposure frequency 1.5 1.6 4.9 -0.8 -1.8 -2.2 -1.5 -0.6 0.1 -0.1
Qualifications: O levels/GCSEs or equivalent 1.7 2.8 5.2 1.7 2.3 1.7 1.1 0.5 1.6 2.1
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 2.2 -0.7 1.5 0.5 -0.1 0.3 0.7 0.3
Blood clot in the leg (DVT) 1.0 1.4 3.9 -2.0 -1.8 -0.0 -1.1 0.4 -0.5 -0.8
Medication: Paracetamol 0.7 1.1 2.1 0.2 1.3 -0.8 -0.7 -1.4 1.0 -1.5
Headache pain in last month 0.4 0.7 1.9 1.4 1.0 -0.8 0.3 -1.0 -0.2 0.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.3 -0.4 0.3 0.5 -0.1 0.7 1.1 0.2
Glaucoma (self-reported) 0.8 0.9 3.4 -0.1 1.1 0.9 0.5 0.6 1.8 0.4
Gout (self-reported) 0.7 1.0 2.7 0.7 1.2 0.5 0.8 -0.1 -1.2 1.6
Hypothyroidism/myxoedema (self-reported) 1.9 3.8 7.3 2.6 2.7 1.8 1.9 0.6 0.3 2.3
Medication: Amlodipine 0.5 0.7 1.7 -1.3 -1.0 -0.7 -1.3 -0.5 -0.2 -0.3
Medication: Ventolin 100micrograms inhaler 0.5 0.7 2.7 1.0 1.6 0.0 0.6 0.1 -0.7 -0.0
Birth weight 0.2 0.5 1.8 -0.9 -0.9 -0.2 -0.1 0.4 -1.3 -0.4
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.8 0.0 0.1 0.9 0.6 0.2 0.4 0.2
High blood pressure (siblings) 0.5 0.7 2.1 -0.3 -1.1 -1.5 -0.5 0.4 -0.9 -0.8
Forced vital capacity (FVC), Best measure 0.9 3.1 6.3 -2.5 -2.1 -1.6 -2.2 0.2 0.2 -1.9
Body fat percentage 1.4 5.4 19.9 -4.5 -2.4 0.7 -1.0 0.9 1.5 -2.7
Leg fat percentage (right) 1.6 5.8 20.8 -4.6 -2.8 0.0 -1.4 0.3 1.3 -2.9
Arm fat-free mass (right) 2.3 11.5 26.9 -5.2 -3.3 -1.7 -3.5 -1.3 0.1 -5.1
Exposure to tobacco smoke outside home 0.4 0.6 2.0 -0.2 -0.6 0.2 -0.7 -1.4 1.1 -0.3
Comparative body size at age 10 0.5 1.3 5.2 0.0 0.7 2.3 1.1 0.8 1.2 -0.2
Number of full brothers 0.2 0.2 0.6 -0.1 0.4 0.5 -0.3 -0.8 0.4 -0.8
Worry too long after embarrassment 0.5 0.9 4.3 -0.6 -0.3 -0.3 -0.6 -0.9 -0.1 -2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.7 0.6 1.3 -0.7 0.3 0.6 0.6 0.2
Wheeze or whistling in the chest in last year 0.4 0.7 1.2 -0.6 1.0 0.9 -0.1 -1.1 1.1 -0.6
Number of children fathered 1.2 1.4 3.6 -0.0 1.1 1.6 0.7 -0.8 1.0 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.6 1.6 1.5 0.6 0.3 0.0 -0.4 -0.2
Age at first live birth 0.9 1.7 3.6 0.8 1.6 1.0 1.5 1.1 -1.9 0.6
Pulse wave peak to peak time 0.3 0.4 1.4 0.5 1.2 -0.0 -0.1 -0.2 -0.5 -0.8
Health satisfaction 0.4 0.5 1.7 -0.3 0.3 -0.2 -0.6 1.3 -1.0 0.4
Shortness of breath walking on level ground 0.8 0.9 1.8 -0.8 -0.6 -0.8 -1.4 0.8 -1.3 -0.5
Qualifications: College or University degree 1.5 4.6 15.7 2.1 2.1 -0.4 1.9 1.3 -1.4 4.0
Eye problems/disorders: None of the above 0.3 0.3 1.0 -0.4 -0.3 0.6 0.5 0.4 -1.0 -0.5
Mouth/teeth dental problems: Loose teeth 1.0 1.1 4.5 2.1 1.2 -0.0 0.6 -0.6 0.9 0.8
Emphysema/chronic bronchitis 0.4 0.5 1.6 -0.1 -0.7 -0.6 -1.3 0.3 0.1 -0.8
Medication for pain relief, constipation, heartburn 0.9 1.5 3.5 0.9 0.7 1.3 1.8 0.9 -0.3 1.9
Neck or shoulder pain in last month 0.3 0.4 0.6 0.5 0.6 0.8 -0.3 -0.8 -0.6 -0.7
Medication: Blood pressure 0.8 1.5 2.5 -0.7 -1.5 -1.5 -1.4 -1.6 -0.9 -0.5
Angina (self-reported) 0.7 1.0 2.3 1.5 0.6 0.4 1.1 1.2 0.0 1.1
Migraine (self-reported) 0.6 0.7 1.9 0.8 0.5 -0.2 0.9 1.1 -0.5 1.4
Medication: Ibuprofen 0.5 0.6 2.6 -0.2 -0.1 0.4 -0.5 -0.1 1.6 -1.0
Medication: Allopurinol 1.0 1.3 3.5 1.2 1.1 0.7 0.6 -0.4 -1.4 1.9
Medication: Omeprazole 0.2 0.2 0.6 -0.5 -0.6 0.3 0.1 0.5 -0.8 -0.0
Medication: Seretide 50 evohaler 1.5 1.7 3.1 -1.0 -1.2 -1.8 -1.8 -0.2 -0.7 -1.7
Mean time to correctly identify matches 1.8 3.4 13.8 2.5 3.7 0.6 1.7 0.3 -0.1 -0.1
Heart disease (mother) 0.9 1.0 2.9 1.7 0.4 -1.3 0.2 0.4 -1.6 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.6 4.7 1.2 2.1 1.4 2.2 1.0 0.1 2.2
Whole body fat mass 1.8 7.4 25.9 -5.1 -2.8 0.4 -1.8 0.4 1.6 -3.5
Leg fat mass (right) 2.5 9.8 32.4 -5.7 -3.3 -0.6 -2.6 -0.2 1.3 -4.0
Arm predicted mass (right) 2.0 10.2 25.2 -5.0 -3.1 -1.4 -3.3 -1.0 0.2 -4.8
Pulse rate, automated reading 0.7 2.3 6.1 0.7 2.3 1.9 -0.3 2.5 -0.5 0.3
Alcohol intake frequency. 0.7 1.6 3.1 0.5 1.2 -0.1 1.1 1.5 -1.8 1.8
Comparative height size at age 10 0.1 0.5 1.0 -1.0 -1.0 -0.4 -0.1 -0.9 0.3 0.4
Number of full sisters 0.6 0.8 2.0 -0.0 1.4 -1.1 -0.6 -0.9 -0.9 0.2
Suffer from ‘nerves’ 0.8 1.2 3.8 -1.3 0.1 -1.6 -0.3 0.5 0.2 -1.9
Overall health rating 1.0 2.1 4.6 -2.1 -1.1 -2.0 -1.6 0.1 0.5 -1.4
Chest pain or discomfort 0.2 0.3 1.0 0.4 1.0 -0.5 -0.4 -0.9 -0.1 -0.0
Had major operations 0.8 1.0 3.8 -0.5 0.1 1.4 0.5 -0.6 -0.3 -2.0
Age at last live birth 1.3 1.8 3.2 1.1 1.5 1.4 1.4 1.8 -0.4 1.5
Family relationship satisfaction 0.4 0.5 1.3 1.1 0.6 0.6 0.4 -0.3 -0.2 1.1
Leg pain on walking 0.2 0.2 0.6 0.6 0.2 -0.3 -0.6 0.0 -0.8 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 6.2 -0.1 1.2 1.1 1.0 2.5 0.8 -0.1
Commuting to job workplace: Car/motor vehicle 0.5 0.5 1.7 -1.3 -1.2 0.5 -0.4 -0.3 -0.4 -0.0
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 4.4 -0.4 -1.4 1.7 -1.2 0.8 2.1 -0.6
Medication: Aspirin 0.1 0.1 0.5 0.2 -0.2 -0.4 0.2 0.7 -0.5 -0.1
Supplements: Vitamin C 1.7 2.0 6.4 2.4 2.5 -0.0 1.1 -0.4 -0.3 0.8
Knee pain experienced in last month 0.8 1.3 6.4 -1.2 -0.2 0.1 -0.4 -0.8 0.2 -2.5
Hypertension (Self-reported) 1.2 3.2 4.8 -1.6 -2.1 -1.6 -2.2 -1.8 -1.1 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.5 6.2 -1.9 -1.4 -1.2 -2.1 -0.2 -0.3 -2.5
Illnesses of father: Heart disease 0.4 0.6 0.9 0.6 -0.7 -0.9 -0.1 0.9 -0.9 0.9
Illnesses of siblings: Diabetes 0.5 0.6 1.1 -0.9 -0.1 -0.8 -0.7 -0.8 0.6 -1.1
Smoking status: Previous 1.5 2.2 4.4 -2.0 -0.7 -0.5 -1.5 1.2 1.7 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.5 8.8 -3.0 -2.1 -0.8 -1.2 -2.3 1.6 -0.9
Whole body fat-free mass 1.8 10.2 26.3 -5.1 -3.0 -1.6 -3.4 -1.3 0.5 -4.5
Leg fat-free mass (right) 1.6 8.6 24.4 -4.9 -2.4 -1.1 -3.0 -0.6 0.6 -4.4
Arm fat percentage (left) 1.5 6.1 21.6 -4.7 -2.7 0.5 -1.5 0.7 1.6 -2.8
Average weekly red wine intake 0.9 1.3 4.1 1.0 2.0 1.0 1.0 0.1 1.0 1.0
Handedness (chirality/laterality): Left-handed 1.4 1.7 3.2 -0.6 -1.5 -0.6 -1.6 -1.8 1.4 -0.9
Mood swings 0.7 1.3 4.3 -0.9 -0.7 0.3 -0.5 -1.3 2.1 -1.2
Loneliness, isolation 0.5 0.8 1.7 -1.1 -1.3 -1.2 -0.5 0.4 -0.4 -0.6
Long-standing illness, disability or infirmity 0.9 1.4 3.8 -1.5 -0.4 -1.9 -1.3 -0.3 -0.7 -1.3
Ever had bowel cancer screening 1.7 2.0 4.8 2.1 2.2 1.3 1.4 0.8 0.7 -0.2
Diabetes diagnosed by doctor 0.6 1.0 4.0 -0.2 0.9 0.3 -0.7 1.2 0.4 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 4.5 0.2 0.5 0.6 -0.4 -1.0 2.1 1.4
Friendships satisfaction 0.8 1.0 2.7 1.0 0.7 1.4 0.8 -0.2 0.4 1.7
Qualifications: nursing, teaching 1.2 1.9 6.1 2.5 1.6 0.6 1.4 0.2 -0.0 1.5
Commuting to job workplace: Walk 1.0 1.1 2.0 1.2 1.3 0.1 1.4 1.2 -0.7 0.7
Eye problems/disorders: Cataract 0.7 0.9 3.5 0.0 0.3 -1.4 -0.6 -0.2 1.9 0.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.6 -1.6 -0.4 0.0 0.0 0.9 -0.5 -1.4
Medication for cholesterol 0.7 1.1 2.5 1.5 0.8 -0.8 0.4 0.8 1.6 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.5 2.6 -0.2 0.2 -1.6 -1.3 -1.5 -1.0 -1.6
Back pain experienced in last month 0.2 0.3 0.8 -0.3 -0.6 -0.8 -0.2 -0.7 0.3 -0.9
Mineral and other dietary supplements 1.4 1.8 6.8 -1.0 -1.5 1.0 -0.4 1.1 0.6 2.6
Breast cancer (self-reported) 0.5 0.6 1.9 -0.4 -1.0 -0.9 -1.4 0.3 0.0 -0.1
Asthma (self-reported) 0.9 1.8 8.4 1.2 2.9 0.2 1.3 1.0 -0.1 0.6
Osteoporosis (self-reported) 1.5 1.9 4.5 -1.9 -0.2 -2.1 -1.6 -0.4 -0.6 -1.4
Osteoarthritis (self-reported) 1.6 2.0 4.5 -0.8 -2.1 -1.7 -1.6 -1.6 -0.9 0.2
Medication: Aspirin 0.2 0.3 0.7 0.1 -0.5 -0.5 0.4 0.8 -0.9 -0.1
Medication: Gliclazide 0.4 0.5 1.8 -0.9 0.6 -0.0 0.2 1.3 -0.6 -0.2
Illnesses of father: None of the above (group 1) 1.0 1.2 3.3 -0.3 -0.5 1.8 0.5 -1.1 1.5 1.0
Smoking status: Current 0.8 1.3 5.3 -1.2 -2.3 -0.1 -0.3 -1.3 0.5 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.7 -0.2 -1.0 -1.1 -1.3 0.2 -0.2 0.3
Whole body water mass 1.9 10.8 27.2 -5.2 -3.1 -1.6 -3.5 -1.4 0.5 -4.6
Leg predicted mass (right) 1.6 8.4 24.2 -4.9 -2.3 -1.0 -3.0 -0.5 0.6 -4.3
Arm fat mass (left) 2.2 9.1 30.5 -5.5 -3.3 -0.0 -2.2 -0.0 1.5 -3.9
Number of self-reported non-cancer illnesses 0.5 0.9 2.8 -0.1 -0.1 -1.6 -0.9 0.0 -1.7 0.0
Average weekly champagne plus white wine intake 1.8 2.5 4.2 1.6 1.8 2.0 1.6 0.6 2.1 0.5
Miserableness 3.0 5.2 10.6 -2.0 -2.0 -2.4 -3.3 -2.2 1.2 -2.5
Guilty feelings 0.5 0.8 3.1 -0.8 0.0 -0.7 -0.7 0.9 0.3 -1.8
Wears glasses or contact lenses 0.2 0.2 0.6 -0.4 -0.6 -0.3 0.4 0.8 -0.4 -0.1
Ever taken oral contraceptive pill 3.0 3.3 11.8 -0.7 -1.1 -0.9 -2.4 -3.4 1.6 -1.0
Hearing aid user 0.2 0.2 0.8 0.2 0.9 -0.6 -0.3 0.1 -0.5 0.0
Mother’s age at death 0.4 0.5 1.6 -0.7 -0.7 -0.5 -0.2 -0.9 -1.3 -0.1
Financial situation satisfaction 0.6 0.8 2.7 -0.7 -0.4 -0.7 -1.0 -1.7 -0.6 0.5
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.6 0.5 0.9 0.3 1.6 1.1 -1.6 -0.2
Commuting to job workplace: Public transport 0.5 0.6 1.8 0.8 0.1 1.0 0.0 -0.9 1.3 -0.1
Eye problems/disorders: Glaucoma 0.5 0.5 1.6 -0.4 0.6 -1.0 -1.3 -0.3 0.7 -0.1
Medication: Blood pressure 0.8 1.6 5.9 -1.6 -2.4 -0.0 -1.1 -1.1 0.2 -0.4
Pain type(s) experienced in last month: Hip pain 3.3 4.2 6.8 -2.5 -1.7 -2.6 -2.5 -0.2 -1.0 -2.5
Supplements: Fish oil (including cod liver oil) 0.9 1.1 4.3 0.7 1.1 -1.0 0.4 -0.7 0.3 -2.1
High cholesterol (Self-reported) 0.3 0.6 1.6 -0.5 -1.3 0.4 -0.3 -0.5 -0.3 -1.3
Medication: Bendroflumethiazide 0.8 1.3 3.7 -1.4 -1.9 0.4 -0.8 -0.7 -1.0 1.1
Medication: Paracetamol 0.6 0.9 2.3 0.2 0.9 -1.0 -1.5 -1.0 0.8 -0.8
Medication: Lisinopril 1.0 1.3 4.1 -0.5 -0.6 -0.6 -1.1 -2.0 -1.4 -0.7
Medication: Atorvastatin 4.4 5.5 13.0 -3.6 -3.4 -0.9 -2.7 -0.9 0.2 -2.2
Illnesses of father: High blood pressure 1.8 2.2 7.8 -0.6 0.5 -2.8 -1.6 0.1 -1.8 -1.2
Alcohol drinker status: Never 1.3 1.6 5.7 -0.8 -0.5 -1.8 0.0 1.2 -2.4 0.3
Ever smoked 0.7 1.3 2.8 -1.5 -1.0 0.8 -0.7 0.7 1.7 -1.2
Basal metabolic rate 2.0 11.3 32.0 -5.7 -3.3 -1.4 -3.3 -1.2 0.6 -4.7
Leg fat percentage (left) 1.4 5.0 17.5 -4.2 -2.3 0.1 -1.2 0.2 1.2 -3.0
Arm fat-free mass (left) 2.5 12.8 32.4 -5.7 -3.8 -1.9 -3.6 -1.5 0.3 -4.9
Number of operations (self-reported) 0.8 1.2 3.6 -0.8 -0.7 -0.4 -1.9 -0.7 -0.3 -1.7
Average weekly beer plus cider intake 1.2 1.8 4.1 -1.5 -2.0 0.5 -1.1 -0.8 1.3 -1.5
Irritability 0.7 1.2 2.9 1.2 1.4 1.7 1.3 0.2 0.4 -0.7
Risk taking 0.7 1.0 3.7 -0.8 -0.2 0.1 -0.2 -1.9 0.1 -1.6
Ever had prostate specific antigen (PSA) test 0.9 1.0 2.1 1.4 1.5 0.5 0.5 0.9 0.7 1.1
Fractured/broken bones in last 5 years 2.6 3.3 5.4 -2.3 -2.3 -1.1 -1.8 -0.5 -2.2 -1.8
Age started oral contraceptive pill 0.3 0.4 0.8 -0.1 -0.5 -0.7 0.7 0.7 -0.9 -0.1
Diastolic blood pressure, automated reading 0.3 0.9 1.9 -0.2 0.6 0.8 -1.1 -0.6 1.4 -1.3
Ever depressed for a whole week 3.1 3.8 8.2 -2.4 -0.7 -2.1 -2.9 -1.7 -0.2 -2.3
Unable to work because of sickness or disability 1.5 1.9 5.8 -1.0 -1.3 -2.4 -1.0 -2.0 0.3 0.1
Commuting to job workplace: Cycle 0.4 0.5 1.5 1.0 0.2 -0.3 0.4 1.2 -0.7 0.7
Myopia 0.3 0.5 1.6 0.6 0.1 0.2 -0.5 -1.3 -0.2 1.1
Vascular/heart problems diagnosed by doctor 1.1 2.9 5.9 1.2 1.9 1.2 2.4 1.9 1.0 1.8
Cholesterol lowering medication 1.7 2.5 7.8 -2.1 -1.8 -0.1 -1.0 -0.3 -0.7 -2.8
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.0 -0.8 -0.3 1.0 0.1 1.4 0.5 -0.1
Pain experienced in last month 1.0 1.7 3.3 1.3 1.0 0.7 1.3 1.8 -0.8 1.8
Supplements: Calcium 0.9 1.0 2.3 0.0 0.1 -1.5 -0.9 -1.4 -1.2 -0.6
Basal cell carcinoma (self-reported) 0.5 0.6 2.7 -0.8 0.0 -0.5 -0.1 -0.1 -1.6 -1.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.4 -0.1 -1.2 -0.1 -0.5 -0.3 -0.9 0.0
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 3.1 -1.8 -1.6 -0.1 -1.1 0.2 -0.7 -0.3
Heart disease (siblings) 0.7 0.8 1.7 -0.7 -1.3 -0.9 -0.8 0.4 -1.3 -0.5
Alcohol drinker status: Previous 1.4 1.5 5.7 -0.5 -0.4 -1.4 -1.2 -2.4 -0.6 -1.0
Pack years of smoking 0.5 0.7 1.5 -1.0 -1.0 -1.2 -0.1 -1.1 0.4 0.6
Impedance of whole body 1.5 7.4 25.5 3.0 1.9 1.2 3.3 1.0 0.7 5.0
Leg fat mass (left) 2.4 9.5 31.1 -5.6 -3.1 -0.6 -2.5 -0.4 1.1 -4.2
Arm predicted mass (left) 2.3 11.6 29.6 -5.4 -3.5 -1.9 -3.3 -1.1 -0.1 -4.8