TWAS hub - ARHGAP15

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0560	0.0133	1.8e-11	0.023	0.044	0.039	0.044	0.036	5.1e-08	6.3e-14	1.0e-12	6.5e-14	8.7e-12
2	YFS	Blood	0.2342	0.0328	0.0e+00	0.088	0.177	0.204	0.207	0.200	3.5e-27	1.1e-55	1.1e-64	1.2e-65	3.1e-63
3	TCGA	Colon Adenocarcinoma	0.1670	0.0550	2.9e-04	0.043	0.090	0.060	NA	0.076	1.6e-03	6.7e-06	2.2e-04	NA	3.5e-05
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0499	0.0207	4.6e-03	0.006	0.008	-0.002	NA	-0.001	6.1e-02	4.2e-02	9.0e-01	NA	4.2e-01
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0759	0.0314	4.9e-03	0.021	0.024	0.031	NA	0.029	1.8e-03	8.7e-04	1.7e-04	NA	2.7e-04
6	TCGA	Liver Hepatocellular Carcinoma	0.3000	0.0890	6.7e-04	0.009	0.029	0.063	NA	0.043	1.2e-01	1.5e-02	6.5e-04	NA	4.1e-03
7	TCGA	Prostate Adenocarcinoma	0.0531	0.0229	5.0e-03	-0.002	0.007	-0.002	NA	-0.001	6.6e-01	5.4e-02	7.0e-01	NA	4.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hayfever/allergic rhinitis (self-reported)	6.2	8.3	16.6	4.1	3.7	3.0	2.0	1.1	1.7	3.2
Hayfever, allergic rhinitis or eczema	5.8	12.5	30.9	5.0	5.6	1.9	2.6	0.6	-0.0	4.6
Allergy or Eczema	5.7	14.9	30.4	5.5	5.3	2.5	2.8	2.1	0.2	5.3
Medication: Atorvastatin	4.4	5.5	13.0	-3.6	-3.4	-0.9	-2.7	-0.9	0.2	-2.2
Alcohol usually taken with meals	3.6	5.8	13.5	3.3	3.7	0.5	2.3	1.0	-2.5	1.8
Tinnitus: Yes, but not now, but have in the past	3.5	3.8	9.0	-0.8	-1.2	-3.0	-2.4	-3.0	-1.0	0.2
Length of working week for main job	3.5	3.9	11.8	-0.9	-1.1	-2.1	-2.2	-3.4	-1.4	-1.4
Pain type(s) experienced in last month: Hip pain	3.3	4.2	6.8	-2.5	-1.7	-2.6	-2.5	-0.2	-1.0	-2.5
Blood White Count	3.2	24.0	85.2	6.5	9.2	4.2	3.6	1.6	-0.2	2.7
Crohns Disease (2017)	3.1	6.8	17.2	4.2	3.8	-0.1	1.6	1.7	0.0	3.2
Type 2 Diabetes (T2D) (2012)	3.1	3.6	10.4	-1.4	-1.2	-3.2	-1.5	-1.7	-1.7	-1.8
Ever depressed for a whole week	3.1	3.8	8.2	-2.4	-0.7	-2.1	-2.9	-1.7	-0.2	-2.3
Miserableness	3.0	5.2	10.6	-2.0	-2.0	-2.4	-3.3	-2.2	1.2	-2.5
Ever taken oral contraceptive pill	3.0	3.3	11.8	-0.7	-1.1	-0.9	-2.4	-3.4	1.6	-1.0
Allergy	2.9	6.6	17.7	-3.6	-4.2	-1.6	-1.4	-1.0	-0.4	-3.1
Falls in the last year	2.7	3.7	7.5	-2.5	-1.2	-1.9	-2.7	-1.0	-0.7	-2.4
Body Mass Index (BMI) (2010)	2.6	3.6	9.1	-2.6	-1.9	-1.2	-2.0	-0.7	0.2	-3.0
Crohns Disease (2012)	2.6	4.2	12.4	3.5	2.8	-0.5	1.2	0.0	-0.2	2.8
Fractured/broken bones in last 5 years	2.6	3.3	5.4	-2.3	-2.3	-1.1	-1.8	-0.5	-2.2	-1.8
Leg fat mass (right)	2.5	9.8	32.4	-5.7	-3.3	-0.6	-2.6	-0.2	1.3	-4.0
Arm fat-free mass (left)	2.5	12.8	32.4	-5.7	-3.8	-1.9	-3.6	-1.5	0.3	-4.9
Bipolar Disorder (2011)	2.4	2.3	9.0	-1.8	-0.3	-1.5	-0.6	-0.8	-0.9	-3.0
Average weekly fortified wine intake	2.4	2.8	5.7	1.8	1.6	1.3	2.2	1.2	-0.4	2.4
Leg fat mass (left)	2.4	9.5	31.1	-5.6	-3.1	-0.6	-2.5	-0.4	1.1	-4.2
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	9.0	0.2	-0.1	-2.2	-3.0	-1.9	-0.2	-1.0
Body mass index (BMI)	2.3	10.0	27.7	-5.3	-3.2	-0.3	-2.6	-0.4	0.8	-5.0
Weight	2.3	11.3	36.6	-6.0	-3.5	-0.6	-2.7	-0.6	1.0	-4.6
Arm fat-free mass (right)	2.3	11.5	26.9	-5.2	-3.3	-1.7	-3.5	-1.3	0.1	-5.1
Arm predicted mass (left)	2.3	11.6	29.6	-5.4	-3.5	-1.9	-3.3	-1.1	-0.1	-4.8
Age at First Birth	2.2	3.2	6.9	1.9	1.7	0.6	2.6	-0.5	-2.5	1.4
Arm fat mass (right)	2.2	9.1	30.2	-5.5	-3.4	-0.1	-2.4	-0.4	1.6	-3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.5	6.2	-1.9	-1.4	-1.2	-2.1	-0.2	-0.3	-2.5
Arm fat mass (left)	2.2	9.1	30.5	-5.5	-3.3	-0.0	-2.2	-0.0	1.5	-3.9
Bipolar Disorder (2018)	2.1	3.4	7.4	-2.7	-1.6	-1.1	-1.4	-1.9	-0.1	-2.7
BMI	2.1	11.9	32.8	-5.5	-2.7	-0.2	-3.5	-0.2	0.5	-5.7
Hair/balding pattern: Pattern 2	2.1	2.6	11.4	-1.0	-0.4	-3.4	-0.5	-0.1	-2.3	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.6	4.7	1.2	2.1	1.4	2.2	1.0	0.1	2.2
Leg predicted mass (left)	2.0	10.4	30.4	-5.5	-3.0	-1.1	-3.3	-0.7	0.7	-4.6
Breastfed as a baby	2.0	2.4	6.1	0.4	2.5	0.6	1.7	1.5	-2.3	-0.3
Ever highly irritable/argumentative for 2 days	2.0	2.4	5.8	-1.4	-1.8	-1.3	-1.8	-0.9	-0.7	-2.4
Arm predicted mass (right)	2.0	10.2	25.2	-5.0	-3.1	-1.4	-3.3	-1.0	0.2	-4.8
Basal metabolic rate	2.0	11.3	32.0	-5.7	-3.3	-1.4	-3.3	-1.2	0.6	-4.7
Leg fat-free mass (left)	1.9	10.3	30.2	-5.5	-2.9	-1.0	-3.2	-0.6	0.7	-4.6
Had other major operations	1.9	2.3	5.0	-1.7	-0.9	-0.9	-2.2	-1.4	1.1	-1.9
Hypothyroidism/myxoedema (self-reported)	1.9	3.8	7.3	2.6	2.7	1.8	1.9	0.6	0.3	2.3
Whole body water mass	1.9	10.8	27.2	-5.2	-3.1	-1.6	-3.5	-1.4	0.5	-4.6
Stomach or abdominal pain in last month	1.8	2.3	4.2	-0.5	-1.0	-1.9	-2.1	-2.0	0.3	-1.7
Qualifications: None of the above	1.8	4.0	10.6	-2.3	-2.7	0.0	-1.4	-1.5	-0.2	-3.3
Father’s age at death	1.8	2.4	10.1	0.8	1.8	-1.4	0.2	0.7	-3.2	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	6.7	-2.0	-1.4	-2.4	-2.6	-0.8	0.3	-1.2
Impedance of arm (left)	1.8	8.1	25.2	3.0	2.1	1.8	3.3	1.6	0.9	5.0
Mean time to correctly identify matches	1.8	3.4	13.8	2.5	3.7	0.6	1.7	0.3	-0.1	-0.1
Whole body fat mass	1.8	7.4	25.9	-5.1	-2.8	0.4	-1.8	0.4	1.6	-3.5
Whole body fat-free mass	1.8	10.2	26.3	-5.1	-3.0	-1.6	-3.4	-1.3	0.5	-4.5
Average weekly champagne plus white wine intake	1.8	2.5	4.2	1.6	1.8	2.0	1.6	0.6	2.1	0.5
Illnesses of father: High blood pressure	1.8	2.2	7.8	-0.6	0.5	-2.8	-1.6	0.1	-1.8	-1.2
Rheumatoid Arthritis	1.7	2.3	5.2	-1.6	-1.6	-1.7	-1.6	-0.4	-0.4	-2.3
Cardiovascular Disease	1.7	5.6	9.9	-2.5	-2.8	-1.2	-2.9	-3.1	0.1	-2.3
Trunk fat mass	1.7	7.2	26.2	-5.1	-2.6	0.3	-1.8	0.4	1.4	-3.5
Trunk fat-free mass	1.7	10.0	23.5	-4.8	-3.2	-1.8	-3.5	-1.9	0.4	-4.1
Prospective memory result	1.7	2.1	4.6	1.7	1.3	2.2	1.9	0.6	0.1	1.4
Trunk predicted mass	1.7	9.7	22.5	-4.7	-3.2	-1.9	-3.5	-1.9	0.3	-4.0
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	5.2	1.7	2.3	1.7	1.1	0.5	1.6	2.1
Supplements: Vitamin C	1.7	2.0	6.4	2.4	2.5	-0.0	1.1	-0.4	-0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	8.8	-3.0	-2.1	-0.8	-1.2	-2.3	1.6	-0.9
Ever had bowel cancer screening	1.7	2.0	4.8	2.1	2.2	1.3	1.4	0.8	0.7	-0.2
Cholesterol lowering medication	1.7	2.5	7.8	-2.1	-1.8	-0.1	-1.0	-0.3	-0.7	-2.8
Multivitamins +/- minerals	1.6	2.0	6.1	-0.2	0.2	-1.6	-0.5	-2.5	-0.6	-2.1
Impedance of arm (right)	1.6	7.5	28.3	2.9	2.1	1.3	2.9	0.6	1.0	5.3
Peak expiratory flow (PEF)	1.6	3.7	7.5	-2.6	-2.7	-2.2	-2.1	-0.5	1.6	0.4
Leg fat percentage (right)	1.6	5.8	20.8	-4.6	-2.8	0.0	-1.4	0.3	1.3	-2.9
Leg fat-free mass (right)	1.6	8.6	24.4	-4.9	-2.4	-1.1	-3.0	-0.6	0.6	-4.4
Osteoarthritis (self-reported)	1.6	2.0	4.5	-0.8	-2.1	-1.7	-1.6	-1.6	-0.9	0.2
Leg predicted mass (right)	1.6	8.4	24.2	-4.9	-2.3	-1.0	-3.0	-0.5	0.6	-4.3
Depressed Affect (Nagel 2018)	1.5	3.2	8.3	-2.1	-1.8	-0.8	-1.6	-1.5	1.0	-2.9
Schizophrenia vs Biploar Disorder	1.5	1.9	7.9	1.5	1.5	0.6	2.8	0.2	-0.7	0.5
Smoking Status	1.5	3.5	8.2	-2.9	-2.7	-0.5	-1.5	-0.9	1.9	-1.5
Supplements: Glucosamine	1.5	2.0	5.1	1.2	2.2	-1.1	-0.2	-0.7	-1.6	-1.7
Medication: Atenolol	1.5	1.8	3.9	-1.2	-2.0	-1.7	-1.2	0.4	-1.7	0.4
Arm fat percentage (right)	1.5	5.8	21.3	-4.6	-2.8	0.2	-1.6	0.3	1.6	-2.6
Loud music exposure frequency	1.5	1.6	4.9	-0.8	-1.8	-2.2	-1.5	-0.6	0.1	-0.1
Qualifications: College or University degree	1.5	4.6	15.7	2.1	2.1	-0.4	1.9	1.3	-1.4	4.0
Medication: Seretide 50 evohaler	1.5	1.7	3.1	-1.0	-1.2	-1.8	-1.8	-0.2	-0.7	-1.7
Smoking status: Previous	1.5	2.2	4.4	-2.0	-0.7	-0.5	-1.5	1.2	1.7	-2.1
Arm fat percentage (left)	1.5	6.1	21.6	-4.7	-2.7	0.5	-1.5	0.7	1.6	-2.8
Osteoporosis (self-reported)	1.5	1.9	4.5	-1.9	-0.2	-2.1	-1.6	-0.4	-0.6	-1.4
Unable to work because of sickness or disability	1.5	1.9	5.8	-1.0	-1.3	-2.4	-1.0	-2.0	0.3	0.1
Impedance of whole body	1.5	7.4	25.5	3.0	1.9	1.2	3.3	1.0	0.7	5.0
Breast Cancer	1.4	3.3	7.6	-1.9	-2.1	-1.5	-2.3	-0.7	0.1	-2.8
Lung FVC	1.4	7.1	10.4	-2.6	-2.7	-2.4	-3.1	1.1	-3.2	-3.0
Chronotype (morning person)	1.4	3.3	9.9	-1.4	-1.2	-0.8	-2.2	-3.1	0.1	-2.2
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.8	0.8	0.5	-0.4	0.1	1.8	-1.9	1.9
Mouth/teeth dental problems	1.4	2.1	7.5	2.7	0.5	0.8	0.7	-1.3	-0.3	2.0
Qualifications: A levels/AS levels or equivalent	1.4	3.1	8.3	1.7	2.4	1.1	1.2	1.0	1.0	2.9
Exposure to tobacco smoke at home	1.4	1.6	5.2	-0.9	-2.3	-0.9	-0.9	-1.9	0.0	-0.1
Hair/balding pattern: Pattern 4	1.4	3.3	7.4	1.6	0.0	2.7	2.2	1.9	1.5	1.6
Body fat percentage	1.4	5.4	19.9	-4.5	-2.4	0.7	-1.0	0.9	1.5	-2.7
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.4	-0.4	-1.4	1.7	-1.2	0.8	2.1	-0.6
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.2	-0.6	-1.5	-0.6	-1.6	-1.8	1.4	-0.9
Mineral and other dietary supplements	1.4	1.8	6.8	-1.0	-1.5	1.0	-0.4	1.1	0.6	2.6
Leg fat percentage (left)	1.4	5.0	17.5	-4.2	-2.3	0.1	-1.2	0.2	1.2	-3.0
Alcohol drinker status: Previous	1.4	1.5	5.7	-0.5	-0.4	-1.4	-1.2	-2.4	-0.6	-1.0
Reaction Time	1.3	2.5	10.7	1.6	3.3	0.1	1.8	-1.1	-0.4	0.3
Fasting Glucose	1.3	1.6	6.1	-2.5	-1.0	-0.3	-1.1	0.9	-0.7	-1.2
Diabetes (father)	1.3	1.6	3.6	0.7	1.7	1.1	1.9	1.0	0.1	-1.3
Happiness	1.3	1.6	3.0	1.3	1.4	1.0	1.4	-0.5	-1.1	1.7
Age at last live birth	1.3	1.8	3.2	1.1	1.5	1.4	1.4	1.8	-0.4	1.5
Alcohol drinker status: Never	1.3	1.6	5.7	-0.8	-0.5	-1.8	0.0	1.2	-2.4	0.3
Depression (Nagel 2018)	1.2	1.9	3.9	-1.7	0.0	-1.6	-1.2	-1.0	-1.0	-2.0
Major Depression (MDD)	1.2	1.4	3.5	-0.9	-0.7	-1.0	-1.1	-1.9	0.9	-1.5
Trunk fat percentage	1.2	4.7	17.8	-4.2	-2.1	0.8	-0.9	0.9	1.4	-2.6
Relative age voice broke	1.2	1.8	7.4	-0.2	-1.4	-2.7	-1.3	-0.5	0.8	0.5
Impedance of leg (left)	1.2	6.0	21.8	2.9	1.8	0.3	2.9	0.2	0.4	4.7
Waist circumference	1.2	4.5	15.2	-3.9	-2.4	0.1	-1.4	-0.1	1.2	-2.6
Past tobacco smoking	1.2	2.3	4.6	2.1	1.4	0.6	1.5	-1.0	-2.0	1.4
Number of children fathered	1.2	1.4	3.6	-0.0	1.1	1.6	0.7	-0.8	1.0	-1.9
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	6.2	-0.1	1.2	1.1	1.0	2.5	0.8	-0.1
Hypertension (Self-reported)	1.2	3.2	4.8	-1.6	-2.1	-1.6	-2.2	-1.8	-1.1	-1.9
Qualifications: nursing, teaching	1.2	1.9	6.1	2.5	1.6	0.6	1.4	0.2	-0.0	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	2.6	-0.2	0.2	-1.6	-1.3	-1.5	-1.0	-1.6
Average weekly beer plus cider intake	1.2	1.8	4.1	-1.5	-2.0	0.5	-1.1	-0.8	1.3	-1.5
Blood Platelet Count	1.1	13.2	41.7	3.7	6.5	4.1	3.2	0.9	0.8	2.8
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.6	-1.0	-0.4	0.2	-1.0	-0.7	-1.6	-2.1
Vitamin and mineral supplements	1.1	1.5	3.3	-0.8	-1.4	1.1	-0.0	1.6	0.8	1.8
High blood pressure	1.1	3.1	5.7	-1.4	-1.6	-1.3	-2.4	-2.1	-0.9	-2.1
Chronic bronchitis/emphysema (father)	1.1	1.3	5.7	-0.8	0.2	-0.5	-0.2	2.4	-1.3	-0.9
Illnesses of mother	1.1	1.4	3.7	-0.9	-0.0	1.9	1.0	1.9	0.5	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	3.7	-1.6	-0.6	-1.6	-1.5	0.0	0.1	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	4.5	0.2	0.5	0.6	-0.4	-1.0	2.1	1.4
Vascular/heart problems diagnosed by doctor	1.1	2.9	5.9	1.2	1.9	1.2	2.4	1.9	1.0	1.8
Coronary Artery Disease (CAD)	1.0	1.2	4.4	0.9	1.1	0.4	1.0	0.5	-2.1	0.5
Lupus	1.0	1.5	3.7	-1.0	0.1	-1.4	-1.1	-1.5	1.9	-0.3
Hypothyroidism (self reported)	1.0	2.4	5.8	2.3	2.4	1.5	1.0	-0.6	0.4	1.4
Average weekly spirits intake	1.0	1.2	2.6	-1.6	-1.4	-1.0	-1.0	-0.1	0.7	-1.1
Supplements: Zinc	1.0	1.0	3.2	-1.1	0.3	-1.4	-0.6	-1.8	-0.2	-0.7
Impedance of leg (right)	1.0	4.9	20.1	2.4	1.1	0.2	2.7	0.0	0.6	4.5
High blood pressure (mother)	1.0	1.4	5.0	0.6	0.5	-2.2	-0.9	-1.8	0.4	0.3
Number of incorrect matches in round	1.0	1.6	3.7	-0.8	0.3	-1.8	-1.9	-1.1	-0.9	-1.5
Financial difficulties in last 2 years	1.0	1.3	3.4	-1.1	-0.7	-1.8	-1.5	-1.0	0.4	-0.8
Medication: Lansoprazole	1.0	1.2	4.6	0.4	0.7	0.6	0.4	2.1	-1.1	-1.1
Blood clot in the leg (DVT)	1.0	1.4	3.9	-2.0	-1.8	-0.0	-1.1	0.4	-0.5	-0.8
Mouth/teeth dental problems: Loose teeth	1.0	1.1	4.5	2.1	1.2	-0.0	0.6	-0.6	0.9	0.8
Medication: Allopurinol	1.0	1.3	3.5	1.2	1.1	0.7	0.6	-0.4	-1.4	1.9
Overall health rating	1.0	2.1	4.6	-2.1	-1.1	-2.0	-1.6	0.1	0.5	-1.4
Commuting to job workplace: Walk	1.0	1.1	2.0	1.2	1.3	0.1	1.4	1.2	-0.7	0.7
Illnesses of father: None of the above (group 1)	1.0	1.2	3.3	-0.3	-0.5	1.8	0.5	-1.1	1.5	1.0
Medication: Lisinopril	1.0	1.3	4.1	-0.5	-0.6	-0.6	-1.1	-2.0	-1.4	-0.7
Pain experienced in last month	1.0	1.7	3.3	1.3	1.0	0.7	1.3	1.8	-0.8	1.8
Bipolar Disorder or Schizophrenia	0.9	2.3	6.2	-2.5	-1.2	-0.8	0.6	-0.7	-1.3	-2.3
Neuroticism (Nagel 2018)	0.9	2.0	7.7	-1.8	-1.1	-0.8	-0.6	-1.1	-0.0	-2.8
Prostate Cancer	0.9	1.3	4.8	0.7	-0.7	1.5	0.2	2.2	-0.7	0.6
Schizophrenia (2014)	0.9	1.9	5.2	-1.0	0.5	-0.1	2.3	0.7	-2.2	-1.3
Ever had hysterectomy (womb removed)	0.9	1.0	2.9	0.4	0.4	-0.7	-1.3	-1.7	-0.1	-1.2
Medication for hormone replacement therapy	0.9	1.0	2.4	-0.4	1.3	1.4	1.6	0.1	-0.9	0.5
Fed-up feelings	0.9	1.6	6.8	-0.9	-0.8	-0.7	-1.4	-0.1	0.9	-2.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	3.8	-0.6	-0.2	-1.0	-0.9	0.0	-1.9	-1.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	4.6	-0.6	0.4	-2.1	-1.0	-1.1	-0.2	-0.2
Hip circumference	0.9	4.0	16.6	-4.1	-2.1	0.1	-1.1	0.7	0.9	-2.2
Pulse wave reflection index	0.9	1.1	4.0	-0.8	-2.0	-0.6	0.1	-1.3	0.4	0.9
Forced vital capacity (FVC), Best measure	0.9	3.1	6.3	-2.5	-2.1	-1.6	-2.2	0.2	0.2	-1.9
Age at first live birth	0.9	1.7	3.6	0.8	1.6	1.0	1.5	1.1	-1.9	0.6
Medication for pain relief, constipation, heartburn	0.9	1.5	3.5	0.9	0.7	1.3	1.8	0.9	-0.3	1.9
Heart disease (mother)	0.9	1.0	2.9	1.7	0.4	-1.3	0.2	0.4	-1.6	0.1
Average weekly red wine intake	0.9	1.3	4.1	1.0	2.0	1.0	1.0	0.1	1.0	1.0
Long-standing illness, disability or infirmity	0.9	1.4	3.8	-1.5	-0.4	-1.9	-1.3	-0.3	-0.7	-1.3
Asthma (self-reported)	0.9	1.8	8.4	1.2	2.9	0.2	1.3	1.0	-0.1	0.6
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.6	0.5	0.9	0.3	1.6	1.1	-1.6	-0.2
Supplements: Fish oil (including cod liver oil)	0.9	1.1	4.3	0.7	1.1	-1.0	0.4	-0.7	0.3	-2.1
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.1	1.4	1.5	0.5	0.5	0.9	0.7	1.1
Supplements: Calcium	0.9	1.0	2.3	0.0	0.1	-1.5	-0.9	-1.4	-1.2	-0.6
Alzheimer’s Disease (in father)	0.8	0.8	2.5	1.1	1.0	-0.6	0.1	-0.5	0.8	1.6
Primary Biliary Cirrhosis	0.8	1.1	3.2	0.8	1.1	-0.1	0.9	1.8	-0.9	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.4	-1.1	-0.0	-1.4	-1.6	-0.9	-0.4	-0.9
Forced vital capacity (FVC)	0.8	3.0	6.9	-2.6	-2.1	-1.8	-1.9	0.8	-0.3	-1.3
Depression (self-reported)	0.8	1.0	2.7	0.5	1.6	0.3	0.9	1.6	-0.4	-0.7
Glaucoma (self-reported)	0.8	0.9	3.4	-0.1	1.1	0.9	0.5	0.6	1.8	0.4
Shortness of breath walking on level ground	0.8	0.9	1.8	-0.8	-0.6	-0.8	-1.4	0.8	-1.3	-0.5
Medication: Blood pressure	0.8	1.5	2.5	-0.7	-1.5	-1.5	-1.4	-1.6	-0.9	-0.5
Suffer from ‘nerves’	0.8	1.2	3.8	-1.3	0.1	-1.6	-0.3	0.5	0.2	-1.9
Had major operations	0.8	1.0	3.8	-0.5	0.1	1.4	0.5	-0.6	-0.3	-2.0
Knee pain experienced in last month	0.8	1.3	6.4	-1.2	-0.2	0.1	-0.4	-0.8	0.2	-2.5
Friendships satisfaction	0.8	1.0	2.7	1.0	0.7	1.4	0.8	-0.2	0.4	1.7
Smoking status: Current	0.8	1.3	5.3	-1.2	-2.3	-0.1	-0.3	-1.3	0.5	-0.0
Medication: Blood pressure	0.8	1.6	5.9	-1.6	-2.4	-0.0	-1.1	-1.1	0.2	-0.4
Medication: Bendroflumethiazide	0.8	1.3	3.7	-1.4	-1.9	0.4	-0.8	-0.7	-1.0	1.1
Number of operations (self-reported)	0.8	1.2	3.6	-0.8	-0.7	-0.4	-1.9	-0.7	-0.3	-1.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.1	-1.8	-1.6	-0.1	-1.1	0.2	-0.7	-0.3
Irritable Bowel Disease (IBD)	0.7	1.6	4.4	1.8	2.1	-0.1	0.8	0.9	-0.6	1.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	-1.2	-0.2	-1.2	-1.1	-0.0	-0.5	-1.3
Current tobacco smoking	0.7	1.2	4.8	-1.3	-2.2	0.1	-0.6	-1.2	0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.1	-0.7	-1.5	-0.4	-1.7	-0.1	2.2	0.1
Serious illness, injury or assault to yourself	0.7	0.9	2.9	-0.3	0.5	-1.7	-0.2	-0.4	-1.5	-0.8
Had menopause	0.7	0.9	2.2	1.0	0.8	0.1	0.9	0.9	-0.8	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	5.7	-0.6	-1.1	-0.7	-1.8	-0.4	2.4	-0.3
Pain all over the body in last month	0.7	0.7	1.8	-0.1	0.3	-1.4	-1.3	-1.2	-0.1	0.0
Diabetes (self-reported)	0.7	1.0	3.7	-0.9	0.0	-0.2	-1.1	1.1	0.2	-1.9
Hair/balding pattern: Pattern 3	0.7	1.0	3.5	-0.3	-0.1	1.1	1.2	1.9	-0.5	0.8
Pulse rate	0.7	1.1	4.5	0.7	2.1	0.8	-0.4	1.2	-0.3	0.7
Asthma	0.7	1.5	7.1	0.9	2.7	0.2	1.1	0.9	0.1	0.6
Medication: Paracetamol	0.7	1.1	2.1	0.2	1.3	-0.8	-0.7	-1.4	1.0	-1.5
Gout (self-reported)	0.7	1.0	2.7	0.7	1.2	0.5	0.8	-0.1	-1.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.6	1.6	1.5	0.6	0.3	0.0	-0.4	-0.2
Angina (self-reported)	0.7	1.0	2.3	1.5	0.6	0.4	1.1	1.2	0.0	1.1
Pulse rate, automated reading	0.7	2.3	6.1	0.7	2.3	1.9	-0.3	2.5	-0.5	0.3
Alcohol intake frequency.	0.7	1.6	3.1	0.5	1.2	-0.1	1.1	1.5	-1.8	1.8
Mood swings	0.7	1.3	4.3	-0.9	-0.7	0.3	-0.5	-1.3	2.1	-1.2
Eye problems/disorders: Cataract	0.7	0.9	3.5	0.0	0.3	-1.4	-0.6	-0.2	1.9	0.3
Medication for cholesterol	0.7	1.1	2.5	1.5	0.8	-0.8	0.4	0.8	1.6	1.0
Ever smoked	0.7	1.3	2.8	-1.5	-1.0	0.8	-0.7	0.7	1.7	-1.2
Irritability	0.7	1.2	2.9	1.2	1.4	1.7	1.3	0.2	0.4	-0.7
Risk taking	0.7	1.0	3.7	-0.8	-0.2	0.1	-0.2	-1.9	0.1	-1.6
Heart disease (siblings)	0.7	0.8	1.7	-0.7	-1.3	-0.9	-0.8	0.4	-1.3	-0.5
Ovarian Cancer	0.6	0.8	2.2	-0.2	-0.6	-1.1	-1.5	-0.0	1.2	-0.3
Mean Putamen Volume	0.6	0.6	1.9	0.4	0.6	-0.9	-0.4	-0.7	-0.8	-1.4
Ulcerative Colitis	0.6	0.8	2.6	-1.0	-0.3	-0.3	-0.8	-0.5	-1.0	-1.6
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.0	-0.2	0.5	-1.4	-0.4	-1.2	-1.3	-0.4
Severe depression (siblings)	0.6	0.7	3.3	-0.9	-0.5	-0.2	-0.7	0.0	-1.8	-0.3
Pack years adult smoking proportion	0.6	0.9	2.0	-1.0	-1.0	-1.4	0.0	-1.1	-0.1	0.9
Medication: Levothyroxine sodium	0.6	1.0	3.3	0.6	1.8	0.6	1.3	-0.2	-0.9	0.0
Sitting height	0.6	4.0	11.4	-3.4	-1.5	-1.1	-2.5	-1.6	0.2	-2.1
Illnesses of siblings	0.6	0.8	2.0	0.7	1.4	1.4	0.8	0.1	0.5	0.8
Alcohol intake versus 10 years previously	0.6	0.9	2.1	0.2	-0.8	1.2	1.3	-0.1	-0.4	1.4
Mouth/teeth dental problems: Dentures	0.6	1.0	1.8	-1.2	-1.3	-1.2	-0.3	0.7	-1.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.4	-1.8	-1.6	-1.6	-1.9	-0.3	0.6	-1.1
Migraine (self-reported)	0.6	0.7	1.9	0.8	0.5	-0.2	0.9	1.1	-0.5	1.4
Number of full sisters	0.6	0.8	2.0	-0.0	1.4	-1.1	-0.6	-0.9	-0.9	0.2
Diabetes diagnosed by doctor	0.6	1.0	4.0	-0.2	0.9	0.3	-0.7	1.2	0.4	-2.0
Financial situation satisfaction	0.6	0.8	2.7	-0.7	-0.4	-0.7	-1.0	-1.7	-0.6	0.5
Medication: Paracetamol	0.6	0.9	2.3	0.2	0.9	-1.0	-1.5	-1.0	0.8	-0.8
Schizophrenia (2018)	0.5	1.1	3.6	-1.0	-0.2	-0.2	1.9	0.7	-1.4	-0.8
Blood Eosinophil Count	0.5	3.9	11.2	0.7	3.4	2.4	1.2	-0.2	1.6	2.5
Systolic Blood Pressure	0.5	2.7	12.8	1.4	-0.5	-0.9	-1.4	-3.6	0.8	0.8
Relative age of first facial hair	0.5	1.1	4.0	-0.5	-0.9	-2.0	-1.2	-0.8	-0.1	0.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.0	0.2	0.2	-0.8	-0.9	-0.5	-0.5	-1.4
Angina	0.5	0.7	1.9	1.4	0.3	0.2	0.8	1.2	-0.2	1.0
Hearing difficulty/problems with background noise	0.5	0.8	2.7	0.7	0.7	-0.7	0.7	0.8	0.3	1.6
Number of live births	0.5	0.8	1.4	0.2	-1.1	1.1	-0.2	1.2	1.0	-0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.6	-1.9	-1.8	-1.4	-1.5	0.5	0.1	-0.2
Medication: Amlodipine	0.5	0.7	1.7	-1.3	-1.0	-0.7	-1.3	-0.5	-0.2	-0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.7	1.0	1.6	0.0	0.6	0.1	-0.7	-0.0
High blood pressure (siblings)	0.5	0.7	2.1	-0.3	-1.1	-1.5	-0.5	0.4	-0.9	-0.8
Comparative body size at age 10	0.5	1.3	5.2	0.0	0.7	2.3	1.1	0.8	1.2	-0.2
Worry too long after embarrassment	0.5	0.9	4.3	-0.6	-0.3	-0.3	-0.6	-0.9	-0.1	-2.1
Medication: Ibuprofen	0.5	0.6	2.6	-0.2	-0.1	0.4	-0.5	-0.1	1.6	-1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.7	-1.3	-1.2	0.5	-0.4	-0.3	-0.4	-0.0
Illnesses of siblings: Diabetes	0.5	0.6	1.1	-0.9	-0.1	-0.8	-0.7	-0.8	0.6	-1.1
Loneliness, isolation	0.5	0.8	1.7	-1.1	-1.3	-1.2	-0.5	0.4	-0.4	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.6	-1.6	-0.4	0.0	0.0	0.9	-0.5	-1.4
Breast cancer (self-reported)	0.5	0.6	1.9	-0.4	-1.0	-0.9	-1.4	0.3	0.0	-0.1
Number of self-reported non-cancer illnesses	0.5	0.9	2.8	-0.1	-0.1	-1.6	-0.9	0.0	-1.7	0.0
Guilty feelings	0.5	0.8	3.1	-0.8	0.0	-0.7	-0.7	0.9	0.3	-1.8
Commuting to job workplace: Public transport	0.5	0.6	1.8	0.8	0.1	1.0	0.0	-0.9	1.3	-0.1
Eye problems/disorders: Glaucoma	0.5	0.5	1.6	-0.4	0.6	-1.0	-1.3	-0.3	0.7	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.0	-0.8	-0.3	1.0	0.1	1.4	0.5	-0.1
Basal cell carcinoma (self-reported)	0.5	0.6	2.7	-0.8	0.0	-0.5	-0.1	-0.1	-1.6	-1.0
Pack years of smoking	0.5	0.7	1.5	-1.0	-1.0	-1.2	-0.1	-1.1	0.4	0.6
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	0.6	0.8	1.0	0.9	-0.5	-0.1	1.0
Neuroticism (2016)	0.4	0.6	1.5	-0.0	-0.6	0.2	-0.4	-0.9	1.2	-1.1
Height	0.4	8.6	19.4	-4.4	-2.7	-3.5	-3.2	-1.8	-1.4	-2.3
Respiratory disease	0.4	1.0	5.0	1.1	2.2	-0.1	0.5	0.2	-0.2	0.3
Neuroticism	0.4	1.1	5.5	-0.9	0.4	0.7	0.4	-0.3	0.5	-2.3
Age when periods started (menarche)	0.4	0.9	1.5	0.9	0.9	1.1	0.9	1.2	-0.6	0.9
Medication: Ramipril	0.4	0.5	1.2	0.9	-0.7	0.6	1.1	0.5	0.4	0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.2	-0.7	1.5	0.5	-0.1	0.3	0.7	0.3
Headache pain in last month	0.4	0.7	1.9	1.4	1.0	-0.8	0.3	-1.0	-0.2	0.3
Exposure to tobacco smoke outside home	0.4	0.6	2.0	-0.2	-0.6	0.2	-0.7	-1.4	1.1	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.7	0.6	1.3	-0.7	0.3	0.6	0.6	0.2
Wheeze or whistling in the chest in last year	0.4	0.7	1.2	-0.6	1.0	0.9	-0.1	-1.1	1.1	-0.6
Health satisfaction	0.4	0.5	1.7	-0.3	0.3	-0.2	-0.6	1.3	-1.0	0.4
Emphysema/chronic bronchitis	0.4	0.5	1.6	-0.1	-0.7	-0.6	-1.3	0.3	0.1	-0.8
Family relationship satisfaction	0.4	0.5	1.3	1.1	0.6	0.6	0.4	-0.3	-0.2	1.1
Illnesses of father: Heart disease	0.4	0.6	0.9	0.6	-0.7	-0.9	-0.1	0.9	-0.9	0.9
Medication: Gliclazide	0.4	0.5	1.8	-0.9	0.6	-0.0	0.2	1.3	-0.6	-0.2
Mother’s age at death	0.4	0.5	1.6	-0.7	-0.7	-0.5	-0.2	-0.9	-1.3	-0.1
Commuting to job workplace: Cycle	0.4	0.5	1.5	1.0	0.2	-0.3	0.4	1.2	-0.7	0.7
Worry (Nagel 2018)	0.3	0.6	1.9	-0.8	0.3	-1.4	-0.0	-0.3	-0.5	-1.1
LDL Cholesterol	0.3	0.4	1.7	-0.5	-0.2	0.1	-0.3	0.0	1.0	-1.3
Waist Hip Ratio (WHR)	0.3	1.4	4.2	-0.3	-1.1	1.1	0.4	-0.7	2.0	1.6
Lung FEV1/FVC ratio	0.3	1.6	5.6	0.6	-0.7	-0.3	0.2	-0.9	1.9	2.4
Number of treatments/medications taken	0.3	0.5	1.6	-0.4	-0.1	-0.6	-0.8	0.4	-1.3	-0.5
Hearing difficulty/problems: Yes	0.3	0.5	1.5	0.9	1.2	0.3	0.6	0.1	0.4	0.8
Medication: Metformin	0.3	0.5	1.2	-0.3	1.1	0.4	-0.4	1.0	-0.3	-0.8
Diabetes (mother)	0.3	0.4	1.2	1.1	0.6	-0.5	0.1	-0.7	0.6	0.5
Townsend deprivation index at recruitment	0.3	0.4	1.2	-0.0	-0.7	-1.1	-0.7	-0.7	0.2	0.4
Taking other prescription medications	0.3	0.4	1.6	-0.2	0.9	-0.0	-0.1	1.3	-0.7	0.2
Qualifications: CSEs or equivalent	0.3	0.4	1.1	-0.5	-0.9	0.6	0.4	-0.3	-0.0	1.1
Heart attack	0.3	0.3	1.4	0.1	-1.2	-0.0	-0.5	-0.2	-0.8	0.2
Medication: Simvastatin	0.3	0.5	1.4	-0.1	-0.8	0.7	0.4	-0.7	0.0	-1.2
Noisy workplace	0.3	0.4	1.1	-0.1	-0.5	1.1	-0.7	0.2	0.9	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.2	-0.4	0.1	-1.1	-0.0	0.6	-0.8	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.4	-0.5	0.1	0.5	-0.3	-0.0	0.9	-1.2
Medication: Cholesterol lowering	0.3	0.5	1.6	0.0	-0.8	0.3	0.9	0.1	-1.3	-0.3
Lung cancer (father)	0.3	0.3	1.4	-0.1	0.5	-0.3	0.8	0.2	-1.2	-0.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	-0.8	-1.2	0.0	-0.3	0.0	0.5	0.4
Tense / ‘highly strung’	0.3	0.5	1.4	0.9	0.7	-0.2	0.2	-0.6	-1.2	-0.5
Pulse wave peak to peak time	0.3	0.4	1.4	0.5	1.2	-0.0	-0.1	-0.2	-0.5	-0.8
Eye problems/disorders: None of the above	0.3	0.3	1.0	-0.4	-0.3	0.6	0.5	0.4	-1.0	-0.5
Neck or shoulder pain in last month	0.3	0.4	0.6	0.5	0.6	0.8	-0.3	-0.8	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.7	-0.2	-1.0	-1.1	-1.3	0.2	-0.2	0.3
High cholesterol (Self-reported)	0.3	0.6	1.6	-0.5	-1.3	0.4	-0.3	-0.5	-0.3	-1.3
Age started oral contraceptive pill	0.3	0.4	0.8	-0.1	-0.5	-0.7	0.7	0.7	-0.9	-0.1
Diastolic blood pressure, automated reading	0.3	0.9	1.9	-0.2	0.6	0.8	-1.1	-0.6	1.4	-1.3
Myopia	0.3	0.5	1.6	0.6	0.1	0.2	-0.5	-1.3	-0.2	1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.4	-0.1	-1.2	-0.1	-0.5	-0.3	-0.9	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	-0.8	-0.6	-0.1	-1.0	0.9	-0.3	0.9
Alzheimer’s Disease (in mother)	0.2	0.3	1.0	-0.2	-0.2	1.0	0.2	0.2	-0.8	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.5	-0.8	-0.5	-0.6	-0.9	1.2	-0.3	0.7
HbA1C	0.2	0.2	0.7	-0.3	0.4	0.3	-0.2	0.7	0.8	-0.1
Blood Red Count	0.2	1.8	8.7	-0.9	-0.2	1.1	0.8	3.0	0.7	0.7
Heel T-Score	0.2	1.8	3.8	-1.7	-1.9	-1.3	-1.9	0.1	0.6	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.6	-0.5	0.4	0.8	-0.4	0.6	0.2	-1.3
Hand grip strength (left)	0.2	0.5	1.2	-0.7	-0.8	-1.0	0.4	1.1	0.2	0.3
Sensitivity / hurt feelings	0.2	0.4	1.0	0.8	1.0	-0.1	0.3	0.0	0.0	1.0
Systolic blood pressure, automated reading	0.2	0.7	1.6	1.3	0.4	0.3	-1.2	-1.0	0.0	-0.7
Medication: Co-codamol	0.2	0.2	1.1	-0.4	-0.0	-0.3	-0.1	0.0	0.0	1.0
Hand grip strength (right)	0.2	0.6	1.5	-0.5	-0.8	-1.2	0.6	-0.2	-1.0	0.7
Maternal smoking around birth	0.2	0.3	0.7	-0.9	-0.4	-0.5	0.7	-0.2	0.6	-0.1
Nervous feelings	0.2	0.3	1.5	0.6	0.5	-0.2	-0.2	0.2	1.2	0.3
Neuroticism score	0.2	0.5	2.1	-0.2	0.4	0.3	0.0	-0.1	1.0	-1.4
Worrier / anxious feelings	0.2	0.4	1.1	-0.9	-0.9	-1.1	0.1	0.5	-0.1	-0.1
Birth weight of first child	0.2	0.4	1.2	-0.7	-1.0	-1.1	0.2	0.4	0.4	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.3	-0.4	0.3	0.5	-0.1	0.7	1.1	0.2
Birth weight	0.2	0.5	1.8	-0.9	-0.9	-0.2	-0.1	0.4	-1.3	-0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.8	0.0	0.1	0.9	0.6	0.2	0.4	0.2
Number of full brothers	0.2	0.2	0.6	-0.1	0.4	0.5	-0.3	-0.8	0.4	-0.8
Medication: Omeprazole	0.2	0.2	0.6	-0.5	-0.6	0.3	0.1	0.5	-0.8	-0.0
Chest pain or discomfort	0.2	0.3	1.0	0.4	1.0	-0.5	-0.4	-0.9	-0.1	-0.0
Leg pain on walking	0.2	0.2	0.6	0.6	0.2	-0.3	-0.6	0.0	-0.8	-0.4
Back pain experienced in last month	0.2	0.3	0.8	-0.3	-0.6	-0.8	-0.2	-0.7	0.3	-0.9
Medication: Aspirin	0.2	0.3	0.7	0.1	-0.5	-0.5	0.4	0.8	-0.9	-0.1
Wears glasses or contact lenses	0.2	0.2	0.6	-0.4	-0.6	-0.3	0.4	0.8	-0.4	-0.1
Hearing aid user	0.2	0.2	0.8	0.2	0.9	-0.6	-0.3	0.1	-0.5	0.0
Ulcerative Colitis (UC)	0.1	0.3	0.7	-0.8	-0.4	0.1	-0.1	-0.0	-0.7	-0.7
HDL Cholesterol	0.1	0.2	0.5	0.4	0.3	0.7	0.2	-0.2	0.2	0.7
Triglycerides	0.1	0.1	0.2	0.4	0.2	0.2	-0.4	0.4	0.1	-0.2
Tanning	0.1	1.2	2.3	-1.1	-0.7	-0.9	-0.7	1.2	-1.5	-1.3
Fluid intelligence score	0.1	0.3	0.9	-0.6	-0.3	0.2	-0.2	0.7	-0.4	1.0
Time employed in main current job	0.1	0.2	0.3	-0.5	0.5	0.3	0.2	0.2	-0.5	-0.5
Standing height	0.1	1.5	6.5	-2.5	-1.4	-0.9	-0.7	-0.7	0.4	-0.2
Comparative height size at age 10	0.1	0.5	1.0	-1.0	-1.0	-0.4	-0.1	-0.9	0.3	0.4
Medication: Aspirin	0.1	0.1	0.5	0.2	-0.2	-0.4	0.2	0.7	-0.5	-0.1
Hair Pigment	0.0	1.3	2.6	-0.7	-1.1	1.4	1.0	1.6	0.5	1.0

Hub : Genes

ARHGAP15

Models

Trait associations