Hub : Genes

ARHGAP20

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.1900 0.070 0.0024 0.260 NA 0.197 NA 0.220 2.4e-07 NA 8.9e-06 NA 2.4e-06
2 GTEx Brain Cerebellum 0.2240 0.083 0.0039 0.058 NA 0.096 NA 0.036 8.4e-03 NA 9.1e-04 NA 3.1e-02
3 TCGA Lung Squamous Cell Carcinoma 0.0364 0.025 0.0035 0.007 0.018 0.020 NA 0.020 4.9e-02 0.0031 2.2e-03 NA 2.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 1.0 1.3 0.8 1.1 -1.0
Bipolar Disorder or Schizophrenia 1.0 2.5 5.0 1.1 1.2 -2.2
Depressed Affect (Nagel 2018) 0.4 0.9 1.3 1.1 0.8 -0.8
Depression (Nagel 2018) 0.8 1.1 2.0 1.1 1.4 0.4
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.3 0.2 0.5 0.5
Neuroticism (Nagel 2018) 0.0 0.1 0.3 0.5 0.1 -0.1
Schizophrenia (2018) 0.8 1.7 4.1 0.8 0.5 -2.0
Schizophrenia vs Biploar Disorder 0.3 0.4 0.8 0.5 0.3 -0.9
Worry (Nagel 2018) 0.1 0.2 0.4 0.3 -0.6 0.0
Alzheimer’s Disease (in mother) 2.1 2.5 4.7 1.6 2.2 -0.5
Alzheimer’s Disease (in father) 0.1 0.1 0.2 0.4 -0.4 0.3
Alzheimer’s Disease (including proxy) 0.8 1.1 1.8 1.2 1.3 0.2
Crohns Disease (2017) 0.4 0.9 1.5 -0.8 -1.2 0.7
Irritable Bowel Disease (IBD) 1.1 2.6 4.1 -1.3 -2.0 1.4
Ulcerative Colitis (UC) 0.9 1.6 2.2 -1.1 -1.5 1.2
Major Depression (MDD) 3.0 3.6 7.1 1.4 1.3 -2.7
Reaction Time 0.6 1.1 1.7 -1.0 -1.3 0.7
Verbal and Numeric Reasoning (VNR) 0.7 1.7 3.9 2.0 1.2 -0.0
Breast Cancer 0.7 1.8 2.7 1.6 1.6 -0.1
Ovarian Cancer 0.8 1.0 1.1 1.1 1.0 -1.0
Prostate Cancer 0.9 1.2 3.5 -0.3 -1.9 0.4
Age at First Birth 0.6 0.9 2.1 0.8 -1.5 0.3
Bipolar Disorder (2011) 0.1 0.1 0.2 0.5 0.0 -0.2
Body Mass Index (BMI) (2010) 3.0 4.1 6.8 -1.7 -2.6 1.6
Coronary Artery Disease (CAD) 0.2 0.2 0.4 -0.4 -0.6 -0.1
Crohns Disease (2012) 0.5 0.8 1.4 -1.2 -0.9 0.4
Mean Putamen Volume 0.2 0.2 0.3 -0.0 0.5 -0.6
Fasting Glucose 0.9 1.1 2.5 -0.2 -0.9 1.6
HbA1C 1.3 1.4 3.8 -0.7 0.1 2.0
HDL Cholesterol 1.7 2.9 4.2 2.1 1.3 -1.7
LDL Cholesterol 1.3 2.1 4.9 0.4 1.1 -2.2
Lupus 3.4 5.2 8.7 1.9 2.9 -1.8
Neuroticism (2016) 0.1 0.2 0.3 -0.5 0.1 0.5
Primary Biliary Cirrhosis 1.8 2.6 4.4 -1.4 -2.1 1.2
Rheumatoid Arthritis 2.9 3.9 5.1 2.3 2.2 -1.4
Schizophrenia (2014) 0.8 1.8 5.3 0.3 0.3 -2.3
Triglycerides 0.7 1.2 2.8 -1.7 -0.7 0.6
Type 2 Diabetes (T2D) (2012) 2.0 2.3 5.2 -1.0 -2.3 0.9
Ulcerative Colitis 0.1 0.2 0.5 0.3 -0.7 -0.1
Blood Eosinophil Count 0.1 0.8 1.4 -1.2 -0.8 -0.5
Blood Platelet Count 0.1 1.1 3.1 -1.8 -0.4 0.2
Blood Red Count 0.2 2.1 3.8 1.3 0.8 -1.9
Blood White Count 0.3 2.3 4.5 -2.1 -1.0 1.2
Heel T-Score 0.5 3.7 7.0 -2.0 -2.6 -0.5
BMI 1.1 6.6 11.8 -2.6 -3.4 1.0
Height 0.3 5.2 10.6 1.7 1.5 3.3
Waist Hip Ratio (WHR) 2.5 11.2 16.3 -3.4 -4.0 2.4
Systolic Blood Pressure 0.7 3.5 6.4 -2.0 -2.5 0.6
Smoking Status 0.8 1.8 4.8 -0.8 -2.2 0.1
Allergy or Eczema 0.3 0.7 2.1 -1.4 0.1 0.4
Cardiovascular Disease 0.5 1.7 3.7 -1.1 -1.9 -0.2
Hypothyroidism (self reported) 0.6 1.3 1.8 1.3 1.0 -1.1
Respiratory disease 0.3 0.6 0.9 -0.9 0.5 0.9
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.1 -0.4 0.0 -0.0
Lung FEV1/FVC ratio 2.5 12.8 32.6 2.2 0.9 -5.7
Lung FVC 0.1 0.7 1.0 0.7 -0.7 1.0
Neuroticism 0.0 0.1 0.3 0.1 -0.0 0.5
Chronotype (morning person) 0.2 0.4 0.7 -0.6 0.5 0.8
Hair Pigment 0.4 11.9 14.1 -3.0 -3.8 3.5
Tanning 0.0 0.1 0.1 0.3 -0.1 -0.2
Hand grip strength (left) 1.2 3.1 6.1 2.5 1.7 -0.7
Number of treatments/medications taken 0.3 0.6 1.0 0.0 -1.0 0.9
Average weekly spirits intake 0.5 0.6 1.3 0.3 0.7 1.1
Sensitivity / hurt feelings 0.4 0.7 1.9 0.2 0.3 1.4
Frequency of depressed mood in last 2 weeks 0.5 0.6 1.5 -0.6 0.2 1.2
Hearing difficulty/problems: Yes 0.3 0.5 0.6 0.6 0.8 0.6
Relative age of first facial hair 0.4 0.9 1.4 0.8 1.2 -0.8
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 -0.3 0.9 -0.1
Ever used hormone-replacement therapy (HRT) 0.8 1.0 1.6 1.2 1.3 0.1
Ever had hysterectomy (womb removed) 0.1 0.1 0.4 -0.2 0.1 0.6
Systolic blood pressure, automated reading 1.2 3.5 9.1 -0.8 -3.0 0.8
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 -0.2 -0.0 0.4
Angina 0.8 1.0 3.0 0.1 1.7 -0.2
Medication for hormone replacement therapy 3.9 4.3 9.3 1.8 3.1 -0.7
Vitamin and mineral supplements 0.3 0.3 0.9 -0.9 -0.3 0.3
Supplements: Zinc 1.2 1.3 1.6 -1.3 -1.2 -0.8
Medication: Co-codamol 0.1 0.1 0.4 0.6 0.1 0.1
Medication: Metformin 0.7 1.0 1.6 -1.3 -0.9 0.8
Diabetes (father) 0.4 0.5 1.4 -0.2 0.1 1.2
Diabetes (mother) 1.1 1.5 2.8 -1.7 -1.1 -0.5
Severe depression (siblings) 0.5 0.6 1.0 -0.6 -0.5 1.0
Pack years adult smoking proportion 1.3 2.1 2.7 -1.6 -1.0 1.6
Impedance of leg (right) 0.3 1.4 2.0 -1.4 -0.6 1.4
Leg fat-free mass (left) 0.1 0.7 1.0 -0.8 -0.6 1.0
Trunk fat percentage 2.9 11.5 16.3 -3.7 -4.0 2.1
Hand grip strength (right) 1.7 4.6 8.2 2.9 2.0 -1.2
Townsend deprivation index at recruitment 2.3 3.2 4.8 -2.2 -1.5 1.6
Current tobacco smoking 1.1 1.8 3.0 -1.7 -1.1 1.1
Average weekly fortified wine intake 1.4 1.7 3.7 -0.3 1.9 1.1
Maternal smoking around birth 0.1 0.1 0.1 0.2 0.4 -0.3
Fed-up feelings 0.1 0.3 0.7 0.8 -0.1 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.3 -0.1 0.2 1.1
Relative age voice broke 1.8 2.8 3.2 1.7 1.5 -1.8
Taking other prescription medications 0.3 0.4 0.6 -0.8 -0.5 0.6
Age when periods started (menarche) 3.0 7.2 8.4 2.4 2.9 -2.8
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.3 0.5 -0.1 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 6.0 -1.5 -2.5 0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 -0.2 0.9 0.1
Qualifications: CSEs or equivalent 0.3 0.4 0.6 -0.4 0.8 -0.6
Serious illness, injury or assault to yourself 1.3 1.6 2.5 0.5 1.4 -1.6
High blood pressure 0.7 2.0 5.2 -0.5 -2.3 0.8
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.1 -1.0 0.5 0.3
Multivitamins +/- minerals 0.5 0.6 0.9 0.9 0.5 -0.9
Stomach or abdominal pain in last month 0.9 1.1 1.4 -1.2 -1.0 0.9
Supplements: Glucosamine 0.1 0.1 0.2 -0.0 0.4 0.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 0.2 -0.6 -0.4
Medication: Atenolol 0.1 0.1 0.1 0.2 -0.2 0.3
Medication: Levothyroxine sodium 0.2 0.4 0.9 0.4 0.3 -1.0
Sitting height 0.3 2.1 3.3 1.0 1.8 1.4
Chronic bronchitis/emphysema (father) 0.2 0.3 0.5 0.7 0.4 0.4
High blood pressure (mother) 2.6 3.7 5.2 -2.3 -1.9 1.4
Body mass index (BMI) 1.3 5.4 9.1 -2.4 -3.0 1.1
Impedance of leg (left) 0.1 0.2 0.5 -0.7 -0.1 0.5
Leg predicted mass (left) 0.1 0.7 0.9 -0.8 -0.6 1.0
Trunk fat mass 2.3 9.7 13.8 -3.2 -3.7 2.2
Waist circumference 3.3 12.0 17.5 -3.7 -4.2 2.2
Number of incorrect matches in round 1.9 3.2 4.8 -2.2 -2.0 0.7
Past tobacco smoking 0.7 1.3 2.7 0.2 1.6 1.1
Alcohol usually taken with meals 2.6 4.1 7.7 1.3 2.8 -1.7
Nervous feelings 0.0 0.0 0.1 0.3 0.2 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.1 -0.4 0.3 -0.1
Hearing difficulty/problems with background noise 0.7 1.0 2.0 1.0 1.4 0.2
Hair/balding pattern: Pattern 2 3.3 4.2 8.1 0.7 2.0 -2.9
Had menopause 0.4 0.5 0.9 0.6 0.5 1.0
Had other major operations 0.3 0.4 0.7 0.5 -0.4 0.8
Forced vital capacity (FVC) 0.0 0.1 0.3 0.6 -0.3 0.2
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.2 5.6 -1.9 -2.4 0.7
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.9 0.8 1.4 -0.7
Qualifications: None of the above 0.6 1.3 2.6 -0.5 -1.6 1.0
Financial difficulties in last 2 years 1.6 2.2 5.6 -2.4 -0.9 0.4
Mouth/teeth dental problems 0.3 0.5 1.3 -0.3 1.1 -0.0
Heart attack 0.5 0.6 0.9 0.9 1.0 -0.2
Allergy 0.3 0.6 0.9 0.8 -0.9 -0.6
Pain all over the body in last month 1.1 1.1 2.2 1.0 1.5 0.3
Diabetes (self-reported) 0.1 0.2 0.5 -0.2 0.7 0.3
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.1 -1.7 -1.4 0.5
Medication: Ramipril 2.6 3.3 5.7 -1.8 -2.4 0.9
Medication: Simvastatin 3.0 4.3 9.4 -1.6 -3.1 1.0
Fluid intelligence score 1.4 3.0 7.1 2.7 1.1 -0.8
Illnesses of siblings 2.2 3.1 5.3 1.5 2.3 -1.3
Neuroticism score 0.2 0.3 1.0 -0.2 -0.1 1.0
Weight 1.0 5.1 6.1 -2.2 -2.5 2.1
Impedance of arm (right) 0.1 0.5 1.0 -1.0 -0.4 -0.6
Arm fat percentage (right) 2.4 9.5 15.2 -3.5 -3.9 1.2
Trunk fat-free mass 0.1 0.8 2.3 -0.1 -0.1 1.5
Hip circumference 0.6 2.5 3.1 -1.6 -1.8 1.3
Time employed in main current job 1.2 1.4 3.5 0.9 -0.3 1.9
Alcohol intake versus 10 years previously 0.3 0.4 1.0 0.5 0.1 -1.0
Father’s age at death 1.0 1.4 2.6 1.3 1.6 -0.1
Worrier / anxious feelings 1.4 2.6 3.1 -1.5 -1.5 1.8
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.9 -0.7 -0.0 0.9
Falls in the last year 0.5 0.7 1.6 0.7 -0.2 -1.3
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 0.6 -0.0 -0.3
Number of live births 0.5 0.7 1.1 1.0 1.0 -0.3
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 3.8 1.1 -0.1 -1.9
Pulse rate 1.8 3.0 3.9 -2.0 -1.5 1.7
Happiness 0.3 0.3 0.8 0.4 0.9 0.0
Noisy workplace 1.6 2.0 3.5 -1.9 -1.3 1.0
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.5 0.3 1.2 -1.0
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 4.1 1.4 2.0 -1.0
Mouth/teeth dental problems: Dentures 0.4 0.7 1.8 -0.3 -1.3 0.6
Asthma 0.6 1.2 2.9 -1.7 -0.6 0.5
Medication: Ibuprofen (e.g. Nurofen) 2.5 3.2 4.5 -1.8 -1.3 2.1
Medication: Cholesterol lowering 1.4 2.1 3.9 -1.1 -2.0 1.1
Depression (self-reported) 0.7 0.8 1.3 -0.7 1.1 -0.8
Medication: Lansoprazole 1.2 1.3 1.9 1.3 1.4 -0.5
Prospective memory result 0.6 0.7 1.5 0.7 1.2 -0.5
Lung cancer (father) 0.0 0.0 0.0 -0.1 0.2 0.0
Illnesses of mother 1.9 2.4 4.5 1.4 0.8 -2.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.4 9.4 2.4 2.0 -3.1
Pulse wave Arterial Stiffness index 1.4 1.6 2.4 1.0 1.2 -1.6
Impedance of arm (left) 0.0 0.2 0.3 -0.3 0.4 -0.5
Arm fat mass (right) 1.6 6.5 9.6 -2.8 -3.1 1.4
Trunk predicted mass 0.1 0.7 2.1 0.0 0.0 1.4
Standing height 0.2 2.0 4.8 0.4 1.1 2.2
Length of working week for main job 0.7 0.7 1.7 -0.6 -0.3 -1.3
Exposure to tobacco smoke at home 0.4 0.5 1.1 -0.4 -1.1 0.4
Breastfed as a baby 0.4 0.4 0.9 -0.9 -0.6 -0.3
Tense / ‘highly strung’ 0.1 0.2 0.6 0.8 -0.3 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.8 3.6 -0.7 1.9 -1.0
Hair/balding pattern: Pattern 4 0.3 0.7 1.5 0.4 0.7 1.2
Birth weight of first child 0.2 0.3 0.5 -0.7 -0.6 0.4
Peak expiratory flow (PEF) 1.8 4.1 10.0 1.2 -0.8 -3.2
Pulse wave reflection index 2.3 2.8 3.3 1.8 1.8 -1.4
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.1 -0.4 -1.0 0.8
Loud music exposure frequency 3.7 4.0 6.6 2.6 2.1 -1.0
Qualifications: O levels/GCSEs or equivalent 0.0 0.0 0.1 -0.2 0.3 -0.0
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.4 0.2 -1.2 -0.7
Blood clot in the leg (DVT) 0.5 0.7 1.2 0.5 0.8 1.1
Medication: Paracetamol 1.6 2.6 6.2 -2.5 -0.6 1.2
Headache pain in last month 0.6 1.0 2.6 -0.3 -0.6 1.6
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 4.6 0.8 2.1 -1.4
Glaucoma (self-reported) 1.2 1.5 3.6 -1.9 -0.9 -0.3
Gout (self-reported) 0.1 0.1 0.2 0.4 0.2 0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.8 0.3 0.9 -0.4
Medication: Amlodipine 0.7 1.0 1.8 -0.9 -1.4 0.5
Medication: Ventolin 100micrograms inhaler 0.6 0.7 1.8 -0.5 -0.2 1.4
Birth weight 0.3 0.6 1.6 -1.3 0.2 -0.2
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.3 0.5 -0.5 0.2
High blood pressure (siblings) 0.9 1.2 2.6 -0.8 -1.6 0.7
Forced vital capacity (FVC), Best measure 0.8 2.8 3.5 1.9 1.7 -1.3
Body fat percentage 2.7 10.8 16.2 -3.5 -4.0 2.0
Leg fat percentage (right) 2.8 10.0 15.7 -3.2 -4.0 2.0
Arm fat-free mass (right) 0.2 1.1 3.1 -0.4 -0.4 1.8
Exposure to tobacco smoke outside home 1.5 2.0 2.9 -1.4 -1.1 1.7
Comparative body size at age 10 0.2 0.6 0.9 -0.9 -0.3 1.0
Number of full brothers 0.7 0.9 1.8 -1.3 -0.2 0.9
Worry too long after embarrassment 1.3 2.1 5.2 -1.0 -0.4 2.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.4 -1.2 0.5 -0.3
Wheeze or whistling in the chest in last year 0.8 1.4 2.5 -1.6 -1.2 0.4
Number of children fathered 2.0 2.3 6.0 2.4 -0.4 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 0.1 0.6 -0.1
Age at first live birth 0.0 0.1 0.1 -0.1 -0.3 -0.3
Pulse wave peak to peak time 1.3 1.5 2.5 -0.8 -1.1 1.6
Health satisfaction 0.6 0.7 1.9 0.3 -0.5 1.4
Shortness of breath walking on level ground 0.5 0.5 1.4 -1.2 -0.5 0.1
Qualifications: College or University degree 0.3 1.0 2.0 0.0 1.4 -1.0
Eye problems/disorders: None of the above 0.8 1.0 2.3 0.7 -0.3 1.5
Mouth/teeth dental problems: Loose teeth 1.4 1.7 3.1 -1.2 -1.8 -0.8
Emphysema/chronic bronchitis 0.3 0.3 0.5 0.7 0.6 -0.1
Medication for pain relief, constipation, heartburn 0.9 1.6 2.4 1.6 1.1 -1.0
Neck or shoulder pain in last month 0.2 0.3 0.4 0.6 0.6 -0.3
Medication: Blood pressure 2.1 3.7 5.0 -1.2 -2.2 2.1
Angina (self-reported) 1.2 1.6 4.5 0.2 2.1 -0.4
Migraine (self-reported) 1.1 1.4 1.7 -1.3 -1.2 1.1
Medication: Ibuprofen 0.8 1.0 1.2 -1.0 -0.9 1.1
Medication: Allopurinol 0.2 0.3 0.6 0.3 -0.8 0.3
Medication: Omeprazole 0.1 0.2 0.4 -0.4 0.2 0.6
Medication: Seretide 50 evohaler 4.1 4.7 5.6 -2.4 -2.0 2.2
Mean time to correctly identify matches 0.6 1.1 1.7 -0.9 -1.3 1.0
Heart disease (mother) 0.9 1.1 2.8 -0.5 -0.3 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 3.0 -0.7 -1.7 0.2
Whole body fat mass 2.0 8.2 12.0 -3.0 -3.5 1.8
Leg fat mass (right) 1.7 6.5 10.2 -2.6 -3.2 1.6
Arm predicted mass (right) 0.2 1.2 3.3 -0.3 -0.3 1.8
Pulse rate, automated reading 1.3 4.1 5.2 -2.3 -1.7 2.1
Alcohol intake frequency. 0.2 0.4 0.6 0.7 0.8 0.1
Comparative height size at age 10 0.4 2.4 3.1 -1.1 -1.7 1.8
Number of full sisters 0.0 0.0 0.0 0.0 0.1 0.1
Suffer from ‘nerves’ 0.1 0.1 0.2 0.4 0.5 -0.2
Overall health rating 0.3 0.6 1.6 -0.4 -0.5 1.2
Chest pain or discomfort 1.7 2.4 4.0 -1.8 0.0 2.0
Had major operations 0.3 0.3 0.6 -0.3 -0.5 0.8
Age at last live birth 0.5 0.8 1.2 0.6 1.1 -0.9
Family relationship satisfaction 0.1 0.1 0.2 -0.4 0.0 0.4
Leg pain on walking 0.4 0.5 0.8 0.1 0.8 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.1 -0.2 0.4 -1.1
Commuting to job workplace: Car/motor vehicle 1.1 1.3 2.9 0.3 1.7 -0.9
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.8 -0.2 -0.9 0.5
Medication: Aspirin 0.9 1.2 2.8 -0.4 -1.7 0.8
Supplements: Vitamin C 0.2 0.3 0.4 0.7 -0.2 0.6
Knee pain experienced in last month 1.7 2.6 3.9 -2.0 -1.4 1.4
Hypertension (Self-reported) 0.6 1.5 4.2 -0.2 -2.0 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 -0.2 0.7 -0.4
Illnesses of father: Heart disease 1.6 2.2 3.6 -1.9 -1.5 0.9
Illnesses of siblings: Diabetes 0.5 0.6 0.8 -0.9 -0.9 0.4
Smoking status: Previous 0.9 1.3 2.4 1.1 -0.7 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.2 0.0 0.8 -1.1
Whole body fat-free mass 0.1 0.6 1.7 -0.3 -0.3 1.3
Leg fat-free mass (right) 0.0 0.1 0.2 -0.2 -0.2 0.5
Arm fat percentage (left) 2.0 8.0 12.9 -3.1 -3.6 1.1
Average weekly red wine intake 0.1 0.1 0.2 0.4 0.5 0.2
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.0 0.4 1.7 -0.4
Mood swings 0.2 0.3 0.7 0.8 0.0 0.5
Loneliness, isolation 0.5 0.6 1.9 0.2 1.4 0.1
Long-standing illness, disability or infirmity 0.1 0.1 0.2 -0.1 0.4 0.4
Ever had bowel cancer screening 0.3 0.3 0.9 0.2 0.3 1.0
Diabetes diagnosed by doctor 0.2 0.3 0.8 -0.1 0.9 0.5
Ever had stillbirth, spontaneous miscarriage or termination 3.0 3.2 5.7 1.3 2.4 -1.5
Friendships satisfaction 1.0 1.2 2.4 -1.6 -1.1 0.5
Qualifications: nursing, teaching 2.0 3.1 5.0 1.1 1.8 -2.2
Commuting to job workplace: Walk 1.4 1.5 2.3 0.4 -1.5 1.4
Eye problems/disorders: Cataract 0.4 0.5 1.0 -1.0 0.1 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.3 1.1 0.4 0.0
Medication for cholesterol 0.8 1.2 1.8 -1.1 -0.8 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 3.6 1.5 0.5 -1.9
Back pain experienced in last month 0.1 0.1 0.1 -0.4 -0.0 -0.3
Mineral and other dietary supplements 0.5 0.7 1.0 -0.6 -1.0 0.9
Breast cancer (self-reported) 0.2 0.2 0.4 -0.1 -0.3 -0.7
Asthma (self-reported) 0.7 1.5 3.6 -1.9 -0.8 0.4
Osteoporosis (self-reported) 0.7 0.8 1.3 -1.0 0.4 1.1
Osteoarthritis (self-reported) 0.8 1.1 3.1 -0.2 -0.3 1.8
Medication: Aspirin 1.4 1.8 4.0 -0.7 -2.0 1.0
Medication: Gliclazide 3.3 3.8 5.8 -2.4 -1.8 1.5
Illnesses of father: None of the above (group 1) 0.4 0.5 1.0 1.0 0.7 -0.1
Smoking status: Current 1.2 2.0 3.4 -1.8 -1.3 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.1 0.4 0.1 -1.1
Whole body water mass 0.1 0.8 2.1 -0.4 -0.3 1.4
Leg predicted mass (right) 0.0 0.1 0.2 -0.3 -0.3 0.4
Arm fat mass (left) 1.3 5.4 7.7 -2.6 -2.8 1.2
Number of self-reported non-cancer illnesses 0.7 1.2 2.5 -0.8 -0.6 1.6
Average weekly champagne plus white wine intake 0.6 0.9 1.9 -1.4 -0.5 -0.7
Miserableness 0.1 0.2 0.5 0.1 0.1 0.7
Guilty feelings 1.6 2.4 5.9 -2.4 -1.2 0.2
Wears glasses or contact lenses 8.3 9.6 11.1 -2.7 -3.3 3.2
Ever taken oral contraceptive pill 2.6 2.9 5.0 1.2 2.2 -1.5
Hearing aid user 0.1 0.1 0.2 0.1 0.4 -0.1
Mother’s age at death 0.2 0.3 0.8 0.9 0.2 -0.0
Financial situation satisfaction 0.5 0.6 1.2 0.5 0.7 -1.1
Tinnitus: Yes, now most or all of the time 1.5 1.7 2.6 1.6 0.5 -1.5
Commuting to job workplace: Public transport 2.7 3.3 5.5 -0.2 -2.3 2.1
Eye problems/disorders: Glaucoma 0.9 1.1 2.7 -1.7 -0.6 -0.4
Medication: Blood pressure 0.1 0.2 0.5 0.2 -0.7 -0.3
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.6 0.4 0.8 -0.5
Supplements: Fish oil (including cod liver oil) 1.8 2.3 3.3 1.2 1.8 -1.5
High cholesterol (Self-reported) 0.8 1.4 3.7 -0.4 -1.9 0.4
Medication: Bendroflumethiazide 0.7 1.0 2.3 -0.7 -1.5 0.4
Medication: Paracetamol 0.6 0.9 2.5 -1.6 0.2 0.4
Medication: Lisinopril 0.4 0.5 1.3 0.3 0.3 -1.1
Medication: Atorvastatin 0.5 0.6 1.2 0.4 0.7 -1.1
Illnesses of father: High blood pressure 1.1 1.3 1.7 0.9 1.2 -1.3
Alcohol drinker status: Never 2.7 3.3 5.1 1.6 2.2 -1.5
Ever smoked 0.4 0.7 1.5 -0.3 -0.8 -1.2
Basal metabolic rate 0.2 1.1 2.1 -0.9 -0.8 1.4
Leg fat percentage (left) 2.3 8.4 14.6 -2.9 -3.8 1.5
Arm fat-free mass (left) 0.2 0.8 2.2 -0.3 -0.4 1.5
Number of operations (self-reported) 0.9 1.4 2.6 1.6 0.9 -0.9
Average weekly beer plus cider intake 0.8 1.2 3.0 0.7 0.3 -1.7
Irritability 0.1 0.2 0.3 0.4 0.6 0.3
Risk taking 1.3 2.0 5.4 0.7 -0.1 -2.3
Ever had prostate specific antigen (PSA) test 3.1 3.6 6.2 2.1 2.5 -0.4
Fractured/broken bones in last 5 years 0.8 1.0 1.8 0.6 0.8 -1.4
Age started oral contraceptive pill 0.2 0.3 0.9 0.1 0.0 1.0
Diastolic blood pressure, automated reading 0.6 1.9 4.6 -0.7 -2.1 0.7
Ever depressed for a whole week 2.2 2.7 4.2 0.9 2.0 -1.8
Unable to work because of sickness or disability 0.6 0.8 1.4 -1.2 1.0 -0.2
Commuting to job workplace: Cycle 0.4 0.5 0.6 -0.6 -0.6 0.8
Myopia 1.7 2.5 3.8 -1.9 -1.9 0.3
Vascular/heart problems diagnosed by doctor 0.7 2.0 4.9 0.5 2.2 -0.8
Cholesterol lowering medication 0.2 0.3 0.7 0.1 -0.5 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.1 -0.2 0.1 0.2
Pain experienced in last month 0.1 0.1 0.2 0.4 -0.3 -0.2
Supplements: Calcium 0.1 0.2 0.4 -0.2 0.6 -0.2
Basal cell carcinoma (self-reported) 0.2 0.2 0.3 -0.6 -0.2 0.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.7 0.8 0.9 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.0 0.5 0.7 1.0
Heart disease (siblings) 1.2 1.5 2.0 -0.7 -1.4 1.4
Alcohol drinker status: Previous 0.6 0.6 0.8 0.6 0.9 -0.9
Pack years of smoking 1.6 2.3 2.9 -1.7 -1.2 1.6
Impedance of whole body 0.0 0.1 0.4 -0.6 0.1 -0.0
Leg fat mass (left) 1.6 6.1 9.8 -2.5 -3.1 1.4
Arm predicted mass (left) 0.2 1.2 3.0 -0.6 -0.5 1.7