Hub : Genes

ARHGAP20

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.1900	0.070	0.0024	0.260	NA	0.197	NA	0.220	2.4e-07	NA	8.9e-06	NA	2.4e-06
2	GTEx	Brain Cerebellum	0.2240	0.083	0.0039	0.058	NA	0.096	NA	0.036	8.4e-03	NA	9.1e-04	NA	3.1e-02
3	TCGA	Lung Squamous Cell Carcinoma	0.0364	0.025	0.0035	0.007	0.018	0.020	NA	0.020	4.9e-02	0.0031	2.2e-03	NA	2.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	1.3	0.8	1.1	-1.0
Bipolar Disorder or Schizophrenia	1.0	2.5	5.0	1.1	1.2	-2.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.3	1.1	0.8	-0.8
Depression (Nagel 2018)	0.8	1.1	2.0	1.1	1.4	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	0.2	0.5	0.5
Neuroticism (Nagel 2018)	0.0	0.1	0.3	0.5	0.1	-0.1
Schizophrenia (2018)	0.8	1.7	4.1	0.8	0.5	-2.0
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.5	0.3	-0.9
Worry (Nagel 2018)	0.1	0.2	0.4	0.3	-0.6	0.0
Alzheimer’s Disease (in mother)	2.1	2.5	4.7	1.6	2.2	-0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.4	-0.4	0.3
Alzheimer’s Disease (including proxy)	0.8	1.1	1.8	1.2	1.3	0.2
Crohns Disease (2017)	0.4	0.9	1.5	-0.8	-1.2	0.7
Irritable Bowel Disease (IBD)	1.1	2.6	4.1	-1.3	-2.0	1.4
Ulcerative Colitis (UC)	0.9	1.6	2.2	-1.1	-1.5	1.2
Major Depression (MDD)	3.0	3.6	7.1	1.4	1.3	-2.7
Reaction Time	0.6	1.1	1.7	-1.0	-1.3	0.7
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.9	2.0	1.2	-0.0
Breast Cancer	0.7	1.8	2.7	1.6	1.6	-0.1
Ovarian Cancer	0.8	1.0	1.1	1.1	1.0	-1.0
Prostate Cancer	0.9	1.2	3.5	-0.3	-1.9	0.4
Age at First Birth	0.6	0.9	2.1	0.8	-1.5	0.3
Bipolar Disorder (2011)	0.1	0.1	0.2	0.5	0.0	-0.2
Body Mass Index (BMI) (2010)	3.0	4.1	6.8	-1.7	-2.6	1.6
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.4	-0.6	-0.1
Crohns Disease (2012)	0.5	0.8	1.4	-1.2	-0.9	0.4
Mean Putamen Volume	0.2	0.2	0.3	-0.0	0.5	-0.6
Fasting Glucose	0.9	1.1	2.5	-0.2	-0.9	1.6
HbA1C	1.3	1.4	3.8	-0.7	0.1	2.0
HDL Cholesterol	1.7	2.9	4.2	2.1	1.3	-1.7
LDL Cholesterol	1.3	2.1	4.9	0.4	1.1	-2.2
Lupus	3.4	5.2	8.7	1.9	2.9	-1.8
Neuroticism (2016)	0.1	0.2	0.3	-0.5	0.1	0.5
Primary Biliary Cirrhosis	1.8	2.6	4.4	-1.4	-2.1	1.2
Rheumatoid Arthritis	2.9	3.9	5.1	2.3	2.2	-1.4
Schizophrenia (2014)	0.8	1.8	5.3	0.3	0.3	-2.3
Triglycerides	0.7	1.2	2.8	-1.7	-0.7	0.6
Type 2 Diabetes (T2D) (2012)	2.0	2.3	5.2	-1.0	-2.3	0.9
Ulcerative Colitis	0.1	0.2	0.5	0.3	-0.7	-0.1
Blood Eosinophil Count	0.1	0.8	1.4	-1.2	-0.8	-0.5
Blood Platelet Count	0.1	1.1	3.1	-1.8	-0.4	0.2
Blood Red Count	0.2	2.1	3.8	1.3	0.8	-1.9
Blood White Count	0.3	2.3	4.5	-2.1	-1.0	1.2
Heel T-Score	0.5	3.7	7.0	-2.0	-2.6	-0.5
BMI	1.1	6.6	11.8	-2.6	-3.4	1.0
Height	0.3	5.2	10.6	1.7	1.5	3.3
Waist Hip Ratio (WHR)	2.5	11.2	16.3	-3.4	-4.0	2.4
Systolic Blood Pressure	0.7	3.5	6.4	-2.0	-2.5	0.6
Smoking Status	0.8	1.8	4.8	-0.8	-2.2	0.1
Allergy or Eczema	0.3	0.7	2.1	-1.4	0.1	0.4
Cardiovascular Disease	0.5	1.7	3.7	-1.1	-1.9	-0.2
Hypothyroidism (self reported)	0.6	1.3	1.8	1.3	1.0	-1.1
Respiratory disease	0.3	0.6	0.9	-0.9	0.5	0.9
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	-0.4	0.0	-0.0
Lung FEV1/FVC ratio	2.5	12.8	32.6	2.2	0.9	-5.7
Lung FVC	0.1	0.7	1.0	0.7	-0.7	1.0
Neuroticism	0.0	0.1	0.3	0.1	-0.0	0.5
Chronotype (morning person)	0.2	0.4	0.7	-0.6	0.5	0.8
Hair Pigment	0.4	11.9	14.1	-3.0	-3.8	3.5
Tanning	0.0	0.1	0.1	0.3	-0.1	-0.2
Hand grip strength (left)	1.2	3.1	6.1	2.5	1.7	-0.7
Number of treatments/medications taken	0.3	0.6	1.0	0.0	-1.0	0.9
Average weekly spirits intake	0.5	0.6	1.3	0.3	0.7	1.1
Sensitivity / hurt feelings	0.4	0.7	1.9	0.2	0.3	1.4
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.5	-0.6	0.2	1.2
Hearing difficulty/problems: Yes	0.3	0.5	0.6	0.6	0.8	0.6
Relative age of first facial hair	0.4	0.9	1.4	0.8	1.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.3	0.9	-0.1
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.6	1.2	1.3	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.2	0.1	0.6
Systolic blood pressure, automated reading	1.2	3.5	9.1	-0.8	-3.0	0.8
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.2	-0.0	0.4
Angina	0.8	1.0	3.0	0.1	1.7	-0.2
Medication for hormone replacement therapy	3.9	4.3	9.3	1.8	3.1	-0.7
Vitamin and mineral supplements	0.3	0.3	0.9	-0.9	-0.3	0.3
Supplements: Zinc	1.2	1.3	1.6	-1.3	-1.2	-0.8
Medication: Co-codamol	0.1	0.1	0.4	0.6	0.1	0.1
Medication: Metformin	0.7	1.0	1.6	-1.3	-0.9	0.8
Diabetes (father)	0.4	0.5	1.4	-0.2	0.1	1.2
Diabetes (mother)	1.1	1.5	2.8	-1.7	-1.1	-0.5
Severe depression (siblings)	0.5	0.6	1.0	-0.6	-0.5	1.0
Pack years adult smoking proportion	1.3	2.1	2.7	-1.6	-1.0	1.6
Impedance of leg (right)	0.3	1.4	2.0	-1.4	-0.6	1.4
Leg fat-free mass (left)	0.1	0.7	1.0	-0.8	-0.6	1.0
Trunk fat percentage	2.9	11.5	16.3	-3.7	-4.0	2.1
Hand grip strength (right)	1.7	4.6	8.2	2.9	2.0	-1.2
Townsend deprivation index at recruitment	2.3	3.2	4.8	-2.2	-1.5	1.6
Current tobacco smoking	1.1	1.8	3.0	-1.7	-1.1	1.1
Average weekly fortified wine intake	1.4	1.7	3.7	-0.3	1.9	1.1
Maternal smoking around birth	0.1	0.1	0.1	0.2	0.4	-0.3
Fed-up feelings	0.1	0.3	0.7	0.8	-0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	-0.1	0.2	1.1
Relative age voice broke	1.8	2.8	3.2	1.7	1.5	-1.8
Taking other prescription medications	0.3	0.4	0.6	-0.8	-0.5	0.6
Age when periods started (menarche)	3.0	7.2	8.4	2.4	2.9	-2.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.5	-0.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	6.0	-1.5	-2.5	0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	-0.2	0.9	0.1
Qualifications: CSEs or equivalent	0.3	0.4	0.6	-0.4	0.8	-0.6
Serious illness, injury or assault to yourself	1.3	1.6	2.5	0.5	1.4	-1.6
High blood pressure	0.7	2.0	5.2	-0.5	-2.3	0.8
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.1	-1.0	0.5	0.3
Multivitamins +/- minerals	0.5	0.6	0.9	0.9	0.5	-0.9
Stomach or abdominal pain in last month	0.9	1.1	1.4	-1.2	-1.0	0.9
Supplements: Glucosamine	0.1	0.1	0.2	-0.0	0.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.2	-0.6	-0.4
Medication: Atenolol	0.1	0.1	0.1	0.2	-0.2	0.3
Medication: Levothyroxine sodium	0.2	0.4	0.9	0.4	0.3	-1.0
Sitting height	0.3	2.1	3.3	1.0	1.8	1.4
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	0.7	0.4	0.4
High blood pressure (mother)	2.6	3.7	5.2	-2.3	-1.9	1.4
Body mass index (BMI)	1.3	5.4	9.1	-2.4	-3.0	1.1
Impedance of leg (left)	0.1	0.2	0.5	-0.7	-0.1	0.5
Leg predicted mass (left)	0.1	0.7	0.9	-0.8	-0.6	1.0
Trunk fat mass	2.3	9.7	13.8	-3.2	-3.7	2.2
Waist circumference	3.3	12.0	17.5	-3.7	-4.2	2.2
Number of incorrect matches in round	1.9	3.2	4.8	-2.2	-2.0	0.7
Past tobacco smoking	0.7	1.3	2.7	0.2	1.6	1.1
Alcohol usually taken with meals	2.6	4.1	7.7	1.3	2.8	-1.7
Nervous feelings	0.0	0.0	0.1	0.3	0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.1	-0.4	0.3	-0.1
Hearing difficulty/problems with background noise	0.7	1.0	2.0	1.0	1.4	0.2
Hair/balding pattern: Pattern 2	3.3	4.2	8.1	0.7	2.0	-2.9
Had menopause	0.4	0.5	0.9	0.6	0.5	1.0
Had other major operations	0.3	0.4	0.7	0.5	-0.4	0.8
Forced vital capacity (FVC)	0.0	0.1	0.3	0.6	-0.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	5.6	-1.9	-2.4	0.7
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.9	0.8	1.4	-0.7
Qualifications: None of the above	0.6	1.3	2.6	-0.5	-1.6	1.0
Financial difficulties in last 2 years	1.6	2.2	5.6	-2.4	-0.9	0.4
Mouth/teeth dental problems	0.3	0.5	1.3	-0.3	1.1	-0.0
Heart attack	0.5	0.6	0.9	0.9	1.0	-0.2
Allergy	0.3	0.6	0.9	0.8	-0.9	-0.6
Pain all over the body in last month	1.1	1.1	2.2	1.0	1.5	0.3
Diabetes (self-reported)	0.1	0.2	0.5	-0.2	0.7	0.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.1	-1.7	-1.4	0.5
Medication: Ramipril	2.6	3.3	5.7	-1.8	-2.4	0.9
Medication: Simvastatin	3.0	4.3	9.4	-1.6	-3.1	1.0
Fluid intelligence score	1.4	3.0	7.1	2.7	1.1	-0.8
Illnesses of siblings	2.2	3.1	5.3	1.5	2.3	-1.3
Neuroticism score	0.2	0.3	1.0	-0.2	-0.1	1.0
Weight	1.0	5.1	6.1	-2.2	-2.5	2.1
Impedance of arm (right)	0.1	0.5	1.0	-1.0	-0.4	-0.6
Arm fat percentage (right)	2.4	9.5	15.2	-3.5	-3.9	1.2
Trunk fat-free mass	0.1	0.8	2.3	-0.1	-0.1	1.5
Hip circumference	0.6	2.5	3.1	-1.6	-1.8	1.3
Time employed in main current job	1.2	1.4	3.5	0.9	-0.3	1.9
Alcohol intake versus 10 years previously	0.3	0.4	1.0	0.5	0.1	-1.0
Father’s age at death	1.0	1.4	2.6	1.3	1.6	-0.1
Worrier / anxious feelings	1.4	2.6	3.1	-1.5	-1.5	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.9	-0.7	-0.0	0.9
Falls in the last year	0.5	0.7	1.6	0.7	-0.2	-1.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.6	-0.0	-0.3
Number of live births	0.5	0.7	1.1	1.0	1.0	-0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.8	1.1	-0.1	-1.9
Pulse rate	1.8	3.0	3.9	-2.0	-1.5	1.7
Happiness	0.3	0.3	0.8	0.4	0.9	0.0
Noisy workplace	1.6	2.0	3.5	-1.9	-1.3	1.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.5	0.3	1.2	-1.0
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	4.1	1.4	2.0	-1.0
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	-0.3	-1.3	0.6
Asthma	0.6	1.2	2.9	-1.7	-0.6	0.5
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	4.5	-1.8	-1.3	2.1
Medication: Cholesterol lowering	1.4	2.1	3.9	-1.1	-2.0	1.1
Depression (self-reported)	0.7	0.8	1.3	-0.7	1.1	-0.8
Medication: Lansoprazole	1.2	1.3	1.9	1.3	1.4	-0.5
Prospective memory result	0.6	0.7	1.5	0.7	1.2	-0.5
Lung cancer (father)	0.0	0.0	0.0	-0.1	0.2	0.0
Illnesses of mother	1.9	2.4	4.5	1.4	0.8	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.4	9.4	2.4	2.0	-3.1
Pulse wave Arterial Stiffness index	1.4	1.6	2.4	1.0	1.2	-1.6
Impedance of arm (left)	0.0	0.2	0.3	-0.3	0.4	-0.5
Arm fat mass (right)	1.6	6.5	9.6	-2.8	-3.1	1.4
Trunk predicted mass	0.1	0.7	2.1	0.0	0.0	1.4
Standing height	0.2	2.0	4.8	0.4	1.1	2.2
Length of working week for main job	0.7	0.7	1.7	-0.6	-0.3	-1.3
Exposure to tobacco smoke at home	0.4	0.5	1.1	-0.4	-1.1	0.4
Breastfed as a baby	0.4	0.4	0.9	-0.9	-0.6	-0.3
Tense / ‘highly strung’	0.1	0.2	0.6	0.8	-0.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.8	3.6	-0.7	1.9	-1.0
Hair/balding pattern: Pattern 4	0.3	0.7	1.5	0.4	0.7	1.2
Birth weight of first child	0.2	0.3	0.5	-0.7	-0.6	0.4
Peak expiratory flow (PEF)	1.8	4.1	10.0	1.2	-0.8	-3.2
Pulse wave reflection index	2.3	2.8	3.3	1.8	1.8	-1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	-0.4	-1.0	0.8
Loud music exposure frequency	3.7	4.0	6.6	2.6	2.1	-1.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	-0.2	0.3	-0.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.4	0.2	-1.2	-0.7
Blood clot in the leg (DVT)	0.5	0.7	1.2	0.5	0.8	1.1
Medication: Paracetamol	1.6	2.6	6.2	-2.5	-0.6	1.2
Headache pain in last month	0.6	1.0	2.6	-0.3	-0.6	1.6
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	4.6	0.8	2.1	-1.4
Glaucoma (self-reported)	1.2	1.5	3.6	-1.9	-0.9	-0.3
Gout (self-reported)	0.1	0.1	0.2	0.4	0.2	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.8	0.3	0.9	-0.4
Medication: Amlodipine	0.7	1.0	1.8	-0.9	-1.4	0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.8	-0.5	-0.2	1.4
Birth weight	0.3	0.6	1.6	-1.3	0.2	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.5	-0.5	0.2
High blood pressure (siblings)	0.9	1.2	2.6	-0.8	-1.6	0.7
Forced vital capacity (FVC), Best measure	0.8	2.8	3.5	1.9	1.7	-1.3
Body fat percentage	2.7	10.8	16.2	-3.5	-4.0	2.0
Leg fat percentage (right)	2.8	10.0	15.7	-3.2	-4.0	2.0
Arm fat-free mass (right)	0.2	1.1	3.1	-0.4	-0.4	1.8
Exposure to tobacco smoke outside home	1.5	2.0	2.9	-1.4	-1.1	1.7
Comparative body size at age 10	0.2	0.6	0.9	-0.9	-0.3	1.0
Number of full brothers	0.7	0.9	1.8	-1.3	-0.2	0.9
Worry too long after embarrassment	1.3	2.1	5.2	-1.0	-0.4	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.4	-1.2	0.5	-0.3
Wheeze or whistling in the chest in last year	0.8	1.4	2.5	-1.6	-1.2	0.4
Number of children fathered	2.0	2.3	6.0	2.4	-0.4	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	0.1	0.6	-0.1
Age at first live birth	0.0	0.1	0.1	-0.1	-0.3	-0.3
Pulse wave peak to peak time	1.3	1.5	2.5	-0.8	-1.1	1.6
Health satisfaction	0.6	0.7	1.9	0.3	-0.5	1.4
Shortness of breath walking on level ground	0.5	0.5	1.4	-1.2	-0.5	0.1
Qualifications: College or University degree	0.3	1.0	2.0	0.0	1.4	-1.0
Eye problems/disorders: None of the above	0.8	1.0	2.3	0.7	-0.3	1.5
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.1	-1.2	-1.8	-0.8
Emphysema/chronic bronchitis	0.3	0.3	0.5	0.7	0.6	-0.1
Medication for pain relief, constipation, heartburn	0.9	1.6	2.4	1.6	1.1	-1.0
Neck or shoulder pain in last month	0.2	0.3	0.4	0.6	0.6	-0.3
Medication: Blood pressure	2.1	3.7	5.0	-1.2	-2.2	2.1
Angina (self-reported)	1.2	1.6	4.5	0.2	2.1	-0.4
Migraine (self-reported)	1.1	1.4	1.7	-1.3	-1.2	1.1
Medication: Ibuprofen	0.8	1.0	1.2	-1.0	-0.9	1.1
Medication: Allopurinol	0.2	0.3	0.6	0.3	-0.8	0.3
Medication: Omeprazole	0.1	0.2	0.4	-0.4	0.2	0.6
Medication: Seretide 50 evohaler	4.1	4.7	5.6	-2.4	-2.0	2.2
Mean time to correctly identify matches	0.6	1.1	1.7	-0.9	-1.3	1.0
Heart disease (mother)	0.9	1.1	2.8	-0.5	-0.3	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	3.0	-0.7	-1.7	0.2
Whole body fat mass	2.0	8.2	12.0	-3.0	-3.5	1.8
Leg fat mass (right)	1.7	6.5	10.2	-2.6	-3.2	1.6
Arm predicted mass (right)	0.2	1.2	3.3	-0.3	-0.3	1.8
Pulse rate, automated reading	1.3	4.1	5.2	-2.3	-1.7	2.1
Alcohol intake frequency.	0.2	0.4	0.6	0.7	0.8	0.1
Comparative height size at age 10	0.4	2.4	3.1	-1.1	-1.7	1.8
Number of full sisters	0.0	0.0	0.0	0.0	0.1	0.1
Suffer from ‘nerves’	0.1	0.1	0.2	0.4	0.5	-0.2
Overall health rating	0.3	0.6	1.6	-0.4	-0.5	1.2
Chest pain or discomfort	1.7	2.4	4.0	-1.8	0.0	2.0
Had major operations	0.3	0.3	0.6	-0.3	-0.5	0.8
Age at last live birth	0.5	0.8	1.2	0.6	1.1	-0.9
Family relationship satisfaction	0.1	0.1	0.2	-0.4	0.0	0.4
Leg pain on walking	0.4	0.5	0.8	0.1	0.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.1	-0.2	0.4	-1.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.9	0.3	1.7	-0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	-0.2	-0.9	0.5
Medication: Aspirin	0.9	1.2	2.8	-0.4	-1.7	0.8
Supplements: Vitamin C	0.2	0.3	0.4	0.7	-0.2	0.6
Knee pain experienced in last month	1.7	2.6	3.9	-2.0	-1.4	1.4
Hypertension (Self-reported)	0.6	1.5	4.2	-0.2	-2.0	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	-0.2	0.7	-0.4
Illnesses of father: Heart disease	1.6	2.2	3.6	-1.9	-1.5	0.9
Illnesses of siblings: Diabetes	0.5	0.6	0.8	-0.9	-0.9	0.4
Smoking status: Previous	0.9	1.3	2.4	1.1	-0.7	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	0.0	0.8	-1.1
Whole body fat-free mass	0.1	0.6	1.7	-0.3	-0.3	1.3
Leg fat-free mass (right)	0.0	0.1	0.2	-0.2	-0.2	0.5
Arm fat percentage (left)	2.0	8.0	12.9	-3.1	-3.6	1.1
Average weekly red wine intake	0.1	0.1	0.2	0.4	0.5	0.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.0	0.4	1.7	-0.4
Mood swings	0.2	0.3	0.7	0.8	0.0	0.5
Loneliness, isolation	0.5	0.6	1.9	0.2	1.4	0.1
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.1	0.4	0.4
Ever had bowel cancer screening	0.3	0.3	0.9	0.2	0.3	1.0
Diabetes diagnosed by doctor	0.2	0.3	0.8	-0.1	0.9	0.5
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	5.7	1.3	2.4	-1.5
Friendships satisfaction	1.0	1.2	2.4	-1.6	-1.1	0.5
Qualifications: nursing, teaching	2.0	3.1	5.0	1.1	1.8	-2.2
Commuting to job workplace: Walk	1.4	1.5	2.3	0.4	-1.5	1.4
Eye problems/disorders: Cataract	0.4	0.5	1.0	-1.0	0.1	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	1.1	0.4	0.0
Medication for cholesterol	0.8	1.2	1.8	-1.1	-0.8	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.6	1.5	0.5	-1.9
Back pain experienced in last month	0.1	0.1	0.1	-0.4	-0.0	-0.3
Mineral and other dietary supplements	0.5	0.7	1.0	-0.6	-1.0	0.9
Breast cancer (self-reported)	0.2	0.2	0.4	-0.1	-0.3	-0.7
Asthma (self-reported)	0.7	1.5	3.6	-1.9	-0.8	0.4
Osteoporosis (self-reported)	0.7	0.8	1.3	-1.0	0.4	1.1
Osteoarthritis (self-reported)	0.8	1.1	3.1	-0.2	-0.3	1.8
Medication: Aspirin	1.4	1.8	4.0	-0.7	-2.0	1.0
Medication: Gliclazide	3.3	3.8	5.8	-2.4	-1.8	1.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	1.0	0.7	-0.1
Smoking status: Current	1.2	2.0	3.4	-1.8	-1.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	0.4	0.1	-1.1
Whole body water mass	0.1	0.8	2.1	-0.4	-0.3	1.4
Leg predicted mass (right)	0.0	0.1	0.2	-0.3	-0.3	0.4
Arm fat mass (left)	1.3	5.4	7.7	-2.6	-2.8	1.2
Number of self-reported non-cancer illnesses	0.7	1.2	2.5	-0.8	-0.6	1.6
Average weekly champagne plus white wine intake	0.6	0.9	1.9	-1.4	-0.5	-0.7
Miserableness	0.1	0.2	0.5	0.1	0.1	0.7
Guilty feelings	1.6	2.4	5.9	-2.4	-1.2	0.2
Wears glasses or contact lenses	8.3	9.6	11.1	-2.7	-3.3	3.2
Ever taken oral contraceptive pill	2.6	2.9	5.0	1.2	2.2	-1.5
Hearing aid user	0.1	0.1	0.2	0.1	0.4	-0.1
Mother’s age at death	0.2	0.3	0.8	0.9	0.2	-0.0
Financial situation satisfaction	0.5	0.6	1.2	0.5	0.7	-1.1
Tinnitus: Yes, now most or all of the time	1.5	1.7	2.6	1.6	0.5	-1.5
Commuting to job workplace: Public transport	2.7	3.3	5.5	-0.2	-2.3	2.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.7	-1.7	-0.6	-0.4
Medication: Blood pressure	0.1	0.2	0.5	0.2	-0.7	-0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.6	0.4	0.8	-0.5
Supplements: Fish oil (including cod liver oil)	1.8	2.3	3.3	1.2	1.8	-1.5
High cholesterol (Self-reported)	0.8	1.4	3.7	-0.4	-1.9	0.4
Medication: Bendroflumethiazide	0.7	1.0	2.3	-0.7	-1.5	0.4
Medication: Paracetamol	0.6	0.9	2.5	-1.6	0.2	0.4
Medication: Lisinopril	0.4	0.5	1.3	0.3	0.3	-1.1
Medication: Atorvastatin	0.5	0.6	1.2	0.4	0.7	-1.1
Illnesses of father: High blood pressure	1.1	1.3	1.7	0.9	1.2	-1.3
Alcohol drinker status: Never	2.7	3.3	5.1	1.6	2.2	-1.5
Ever smoked	0.4	0.7	1.5	-0.3	-0.8	-1.2
Basal metabolic rate	0.2	1.1	2.1	-0.9	-0.8	1.4
Leg fat percentage (left)	2.3	8.4	14.6	-2.9	-3.8	1.5
Arm fat-free mass (left)	0.2	0.8	2.2	-0.3	-0.4	1.5
Number of operations (self-reported)	0.9	1.4	2.6	1.6	0.9	-0.9
Average weekly beer plus cider intake	0.8	1.2	3.0	0.7	0.3	-1.7
Irritability	0.1	0.2	0.3	0.4	0.6	0.3
Risk taking	1.3	2.0	5.4	0.7	-0.1	-2.3
Ever had prostate specific antigen (PSA) test	3.1	3.6	6.2	2.1	2.5	-0.4
Fractured/broken bones in last 5 years	0.8	1.0	1.8	0.6	0.8	-1.4
Age started oral contraceptive pill	0.2	0.3	0.9	0.1	0.0	1.0
Diastolic blood pressure, automated reading	0.6	1.9	4.6	-0.7	-2.1	0.7
Ever depressed for a whole week	2.2	2.7	4.2	0.9	2.0	-1.8
Unable to work because of sickness or disability	0.6	0.8	1.4	-1.2	1.0	-0.2
Commuting to job workplace: Cycle	0.4	0.5	0.6	-0.6	-0.6	0.8
Myopia	1.7	2.5	3.8	-1.9	-1.9	0.3
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.9	0.5	2.2	-0.8
Cholesterol lowering medication	0.2	0.3	0.7	0.1	-0.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.2	0.1	0.2
Pain experienced in last month	0.1	0.1	0.2	0.4	-0.3	-0.2
Supplements: Calcium	0.1	0.2	0.4	-0.2	0.6	-0.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	-0.6	-0.2	0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.7	0.8	0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.0	0.5	0.7	1.0
Heart disease (siblings)	1.2	1.5	2.0	-0.7	-1.4	1.4
Alcohol drinker status: Previous	0.6	0.6	0.8	0.6	0.9	-0.9
Pack years of smoking	1.6	2.3	2.9	-1.7	-1.2	1.6
Impedance of whole body	0.0	0.1	0.4	-0.6	0.1	-0.0
Leg fat mass (left)	1.6	6.1	9.8	-2.5	-3.1	1.4
Arm predicted mass (left)	0.2	1.2	3.0	-0.6	-0.5	1.7