Hub : Genes

ARHGAP26

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1756	0.0602	3.9e-03	-0.003	NA	-0.003	NA	-0.004	7.3e-01	NA	7.1e-01	NA	7.5e-01
2	ROSMAP	Brain Pre-frontal Cortex	0.2638	0.0452	2.8e-10	0.208	0.139	0.214	0.207	0.193	2.9e-26	1.9e-17	5.6e-27	4.1e-26	2.7e-24
3	TCGA	Lung Adenocarcinoma	0.0574	0.0243	9.0e-03	0.010	0.011	0.002	NA	0.011	2.3e-02	1.6e-02	1.8e-01	NA	1.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	1.0	1.7	-1.3	0.7	0.9
Bipolar Disorder or Schizophrenia	0.9	2.2	6.6	-2.6	-0.0	0.4
Depressed Affect (Nagel 2018)	1.1	2.3	4.0	-2.0	-1.5	0.9
Depression (Nagel 2018)	0.4	0.6	1.2	0.4	0.7	-1.1
Intelligence (Savage-Jansen 2018)	1.0	3.1	7.0	2.7	-0.8	-1.3
Neuroticism (Nagel 2018)	0.6	1.3	1.9	-1.1	-1.4	0.9
Schizophrenia (2018)	0.7	1.4	3.5	-1.9	-0.6	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	0.7	-0.4	0.2
Worry (Nagel 2018)	0.5	1.0	1.8	-0.9	-0.4	1.3
Alzheimer’s Disease (in mother)	0.7	0.8	2.0	-0.0	1.4	-0.7
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.1	-0.4	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	0.8	-0.9	0.8	-0.8
Crohns Disease (2017)	0.1	0.2	0.4	-0.7	-0.2	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.6	-0.6	1.3	0.2
Ulcerative Colitis (UC)	0.6	1.1	2.6	-0.8	1.6	-0.1
Major Depression (MDD)	0.2	0.3	0.5	-0.3	-0.4	-0.7
Reaction Time	1.1	2.1	5.6	-0.8	-0.1	2.4
Verbal and Numeric Reasoning (VNR)	1.5	3.5	9.3	3.0	0.3	-1.1
Breast Cancer	1.2	3.0	6.0	-1.7	-0.1	-2.4
Ovarian Cancer	0.8	1.1	2.9	0.4	0.4	-1.7
Prostate Cancer	0.8	1.1	1.5	-1.1	1.2	-0.7
Age at First Birth	1.1	1.6	3.5	-0.7	1.9	-0.8
Bipolar Disorder (2011)	0.3	0.3	0.9	0.0	0.0	-1.0
Body Mass Index (BMI) (2010)	1.7	2.3	6.2	0.7	-0.3	-2.5
Coronary Artery Disease (CAD)	0.3	0.3	0.9	0.9	0.1	-0.2
Crohns Disease (2012)	0.2	0.4	1.0	-0.4	1.0	-0.1
Mean Putamen Volume	0.6	0.7	1.3	-1.1	-0.4	-0.7
Fasting Glucose	1.2	1.4	2.8	-1.7	-0.3	-1.2
HbA1C	0.6	0.7	1.5	-1.2	-0.7	-0.1
HDL Cholesterol	1.2	2.0	4.3	2.1	-0.8	0.9
LDL Cholesterol	0.8	1.2	3.2	0.6	-1.8	-0.2
Lupus	0.8	1.2	3.5	0.1	-1.9	0.4
Neuroticism (2016)	0.5	0.8	2.1	0.1	-0.4	1.4
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.0	0.2	0.6
Rheumatoid Arthritis	1.7	2.4	5.7	-1.0	-2.4	-0.6
Schizophrenia (2014)	0.6	1.3	3.2	-1.8	-0.2	0.9
Triglycerides	1.5	2.4	5.6	-2.4	0.1	-1.2
Type 2 Diabetes (T2D) (2012)	2.3	2.7	4.8	-2.2	0.0	-1.8
Ulcerative Colitis	0.8	1.2	3.1	0.6	1.8	0.3
Blood Eosinophil Count	0.9	6.6	10.0	-2.0	-3.2	2.4
Blood Platelet Count	0.1	0.9	1.8	1.3	0.2	-0.9
Blood Red Count	0.5	5.3	12.5	-3.5	1.8	0.1
Blood White Count	0.4	3.2	9.3	-3.0	0.6	-0.0
Heel T-Score	0.8	6.3	15.4	-1.7	-0.8	-3.9
BMI	0.5	3.0	6.5	0.2	-1.6	-2.5
Height	0.2	4.7	13.3	-3.6	-0.0	1.0
Waist Hip Ratio (WHR)	2.5	11.4	30.0	-5.5	1.9	-0.9
Systolic Blood Pressure	0.5	2.4	4.9	2.2	-0.1	-1.6
Smoking Status	0.3	0.7	1.0	0.3	-1.0	-0.9
Allergy or Eczema	1.2	3.1	4.5	-2.1	-1.2	1.8
Cardiovascular Disease	0.6	2.1	5.6	2.4	0.7	-0.5
Hypothyroidism (self reported)	0.3	0.6	1.7	0.3	-0.1	-1.3
Respiratory disease	1.6	3.5	7.7	-1.3	-2.8	1.0
Type 2 Diabetes (T2D) (2018)	1.2	2.3	4.8	-0.8	1.1	-2.2
Lung FEV1/FVC ratio	1.5	7.6	15.8	1.1	4.0	-2.4
Lung FVC	1.0	5.3	14.6	-1.1	-0.2	3.8
Neuroticism	0.8	1.9	3.9	-2.0	-1.1	0.6
Chronotype (morning person)	2.0	4.7	6.9	0.6	2.6	-2.6
Hair Pigment	0.0	1.3	2.6	-0.9	0.8	-1.6
Tanning	0.0	0.0	0.0	-0.2	0.2	0.1
Hand grip strength (left)	0.9	2.3	5.5	0.7	0.9	-2.3
Number of treatments/medications taken	2.0	3.6	7.5	0.9	-1.6	-2.7
Average weekly spirits intake	0.2	0.3	0.6	0.3	-0.8	-0.5
Sensitivity / hurt feelings	0.2	0.4	0.8	-0.6	-0.9	-0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	0.0	-0.6	-1.3
Hearing difficulty/problems: Yes	2.1	3.1	4.7	0.4	-2.1	-2.2
Relative age of first facial hair	0.2	0.5	0.6	0.8	-0.5	0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.5	0.4	-0.4	1.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.1	0.9	1.5	-0.7
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	-0.9	0.4	0.1
Systolic blood pressure, automated reading	0.7	2.0	4.4	1.3	0.1	-2.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.3	-0.1	-0.7
Angina	1.0	1.4	2.6	-1.6	-0.2	-1.2
Medication for hormone replacement therapy	1.0	1.1	3.0	1.7	0.0	-0.4
Vitamin and mineral supplements	1.8	2.4	5.3	-2.3	-1.0	1.0
Supplements: Zinc	1.9	2.0	4.1	1.2	-2.0	-0.8
Medication: Co-codamol	1.3	1.5	2.0	-1.0	1.1	-1.4
Medication: Metformin	1.0	1.4	1.8	-1.0	1.3	-1.1
Diabetes (father)	2.9	3.5	6.4	-1.5	2.5	-1.4
Diabetes (mother)	0.6	0.7	1.1	-0.9	0.6	1.1
Severe depression (siblings)	0.0	0.0	0.1	-0.2	-0.1	-0.3
Pack years adult smoking proportion	0.2	0.3	0.4	-0.5	-0.6	-0.6
Impedance of leg (right)	0.6	2.7	5.7	-0.5	1.4	-2.4
Leg fat-free mass (left)	0.1	0.5	0.8	-0.9	-0.8	0.4
Trunk fat percentage	0.5	2.1	4.2	-2.0	-1.0	-1.1
Hand grip strength (right)	0.1	0.3	0.5	0.7	0.6	-0.3
Townsend deprivation index at recruitment	1.7	2.4	7.0	0.4	-0.2	-2.6
Current tobacco smoking	0.3	0.4	0.9	-0.5	0.5	-0.9
Average weekly fortified wine intake	2.6	3.0	5.2	-1.9	0.4	-2.3
Maternal smoking around birth	1.4	2.0	2.8	-1.5	-1.7	-0.9
Fed-up feelings	0.4	0.6	1.0	-0.7	-0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.5	1.2	0.2	-1.9
Relative age voice broke	0.3	0.4	1.2	0.4	1.1	0.1
Taking other prescription medications	2.1	3.3	4.1	-1.3	-2.0	-2.0
Age when periods started (menarche)	0.1	0.2	0.4	0.3	0.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.2	0.9	-1.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	1.7	-0.8	0.9	-1.3
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	5.4	2.3	-0.6	1.3
Qualifications: CSEs or equivalent	0.0	0.0	0.0	0.1	0.1	-0.1
Serious illness, injury or assault to yourself	1.0	1.2	1.8	-1.0	-1.4	-0.9
High blood pressure	0.6	1.7	4.9	2.2	0.2	0.5
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.3	-1.1	-0.7	2.1
Multivitamins +/- minerals	1.9	2.4	4.0	2.0	1.4	-1.1
Stomach or abdominal pain in last month	0.9	1.1	2.2	-0.3	-1.5	1.0
Supplements: Glucosamine	0.5	0.6	1.3	0.7	0.1	-1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-0.4	1.3	0.3
Medication: Atenolol	0.8	1.0	2.7	-1.6	-0.3	-0.4
Medication: Levothyroxine sodium	0.3	0.5	1.1	-0.2	-1.0	-0.5
Sitting height	0.5	3.3	7.8	-2.8	1.4	0.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	-1.0	-1.1	-0.3
High blood pressure (mother)	1.4	2.0	3.1	-0.2	1.8	1.7
Body mass index (BMI)	0.4	1.7	2.8	-0.7	-1.4	-1.7
Impedance of leg (left)	0.5	2.2	3.2	-0.7	1.7	-1.8
Leg predicted mass (left)	0.1	0.5	0.8	-0.9	-0.7	0.4
Trunk fat mass	0.5	2.0	3.5	-1.9	-1.1	-1.2
Waist circumference	0.8	3.0	5.6	-2.4	-0.6	-1.8
Number of incorrect matches in round	0.6	1.1	2.5	-0.7	-1.6	0.4
Past tobacco smoking	0.2	0.3	0.4	-0.6	0.6	0.4
Alcohol usually taken with meals	2.2	3.6	7.4	2.7	-0.2	1.8
Nervous feelings	2.7	5.1	12.6	-0.8	-1.4	3.6
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.3	0.3	0.8	1.8
Hearing difficulty/problems with background noise	0.7	1.2	2.4	-0.0	-1.6	-1.1
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.0	1.1	0.2
Had menopause	0.2	0.2	0.3	0.4	-0.6	-0.3
Had other major operations	0.2	0.2	0.5	0.3	-0.0	-0.7
Forced vital capacity (FVC)	0.6	2.2	5.5	-0.0	1.1	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.3	-0.8	1.8	-1.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.4	-0.6	-0.1
Qualifications: None of the above	2.9	6.2	8.7	-2.9	-1.2	-3.0
Financial difficulties in last 2 years	2.5	3.4	6.9	1.5	-1.0	-2.6
Mouth/teeth dental problems	0.4	0.6	1.5	1.2	-0.3	-0.3
Heart attack	1.0	1.2	3.6	-1.9	0.0	0.1
Allergy	0.3	0.6	0.8	0.9	0.9	-0.6
Pain all over the body in last month	0.5	0.6	1.7	-0.0	0.1	1.3
Diabetes (self-reported)	1.1	1.7	4.3	-0.3	0.9	-2.1
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	4.6	0.8	-1.3	2.1
Medication: Ramipril	0.2	0.3	0.9	-0.1	0.9	0.1
Medication: Simvastatin	0.8	1.2	3.0	-1.7	0.7	-0.1
Fluid intelligence score	2.0	4.1	11.0	3.3	-1.1	-0.5
Illnesses of siblings	0.5	0.8	1.3	0.8	-1.2	-0.5
Neuroticism score	0.9	1.8	2.4	-1.5	-1.5	1.0
Weight	0.4	2.0	2.6	-1.6	-1.1	-1.5
Impedance of arm (right)	0.1	0.3	1.0	-0.2	0.1	1.0
Arm fat percentage (right)	0.4	1.5	2.2	-1.1	-1.5	-1.0
Trunk fat-free mass	0.1	0.3	0.6	-0.8	-0.3	-0.6
Hip circumference	0.3	1.1	2.2	0.1	-1.5	-1.1
Time employed in main current job	1.7	1.9	5.0	-0.6	0.6	2.2
Alcohol intake versus 10 years previously	1.4	2.1	5.0	-2.2	-0.2	-1.1
Father’s age at death	1.7	2.3	6.3	0.8	-0.3	2.5
Worrier / anxious feelings	0.8	1.4	3.9	-0.5	0.4	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	6.2	-2.5	1.3	1.0
Falls in the last year	1.1	1.5	4.2	-0.2	-2.0	-0.5
Hair/balding pattern: Pattern 3	1.3	2.0	5.6	-2.4	0.5	0.3
Number of live births	0.1	0.1	0.2	-0.0	0.1	0.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	7.6	0.3	2.8	1.6
Pulse rate	2.0	3.4	4.6	-2.1	1.9	-1.4
Happiness	1.5	1.8	3.9	0.8	1.0	2.0
Noisy workplace	0.4	0.5	1.3	-0.0	-0.3	1.1
Qualifications: A levels/AS levels or equivalent	0.8	1.9	5.6	0.1	2.4	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	0.9	-0.2	-0.8	-1.0
Mouth/teeth dental problems: Dentures	2.7	4.5	12.0	-3.5	0.8	-0.9
Asthma	1.2	2.5	4.0	-1.1	-2.0	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	4.8	-1.2	0.3	-2.2
Medication: Cholesterol lowering	0.5	0.8	1.4	-1.0	0.1	-1.2
Depression (self-reported)	1.5	1.8	2.7	-1.0	-1.3	-1.6
Medication: Lansoprazole	1.0	1.1	3.0	-0.4	0.3	-1.7
Prospective memory result	1.2	1.4	2.8	-1.2	-0.0	1.7
Lung cancer (father)	0.5	0.6	1.7	-0.1	1.3	0.2
Illnesses of mother	1.6	2.0	3.2	0.7	-1.5	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	10.0	0.3	3.2	1.9
Pulse wave Arterial Stiffness index	0.6	0.7	2.1	0.1	1.5	0.1
Impedance of arm (left)	0.1	0.6	1.3	-0.8	0.0	1.1
Arm fat mass (right)	0.5	2.1	2.2	-1.5	-1.5	-1.4
Trunk predicted mass	0.1	0.4	0.7	-0.9	-0.3	-0.6
Standing height	0.2	2.2	6.2	-2.5	0.6	0.2
Length of working week for main job	2.6	2.9	7.8	-0.7	0.5	-2.8
Exposure to tobacco smoke at home	0.7	0.8	1.6	0.5	-1.3	-0.7
Breastfed as a baby	0.9	1.1	1.7	1.3	-1.0	0.7
Tense / ‘highly strung’	0.6	0.9	1.3	-1.0	-0.7	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	5.6	-0.9	-2.4	-0.6
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	-0.6	0.2	-0.6
Birth weight of first child	2.5	4.5	8.6	-2.1	-0.6	-2.9
Peak expiratory flow (PEF)	0.9	2.1	5.1	0.8	2.2	0.7
Pulse wave reflection index	1.7	2.1	3.3	1.7	0.5	1.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	-0.3	-0.5	0.4
Loud music exposure frequency	0.6	0.6	1.3	0.2	-1.1	-0.8
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.2	-0.0	0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	3.0	1.5	-1.7	0.4
Blood clot in the leg (DVT)	1.6	2.1	5.9	0.1	0.7	-2.4
Medication: Paracetamol	0.5	0.8	1.6	-0.9	-1.3	-0.3
Headache pain in last month	0.4	0.8	0.8	-0.9	-0.8	-0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.5	0.6	-0.7	0.6
Glaucoma (self-reported)	1.0	1.2	3.1	0.1	-0.8	1.7
Gout (self-reported)	0.1	0.2	0.2	-0.5	-0.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.0	0.0	-1.0	-0.3
Medication: Amlodipine	1.4	2.0	2.5	1.6	1.0	-1.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.2	-0.1	-0.6	1.1
Birth weight	0.7	1.5	3.4	0.8	-0.8	1.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.1	0.5	-1.0	1.1
High blood pressure (siblings)	2.3	3.3	8.9	0.9	0.4	3.0
Forced vital capacity (FVC), Best measure	0.9	3.3	8.1	-0.5	1.2	2.8
Body fat percentage	0.6	2.3	3.2	-1.8	-1.1	-1.6
Leg fat percentage (right)	1.1	4.0	9.0	-1.4	-1.1	-3.0
Arm fat-free mass (right)	0.2	0.9	1.7	-1.3	-0.2	-1.0
Exposure to tobacco smoke outside home	0.4	0.5	1.4	-0.1	-0.4	-1.2
Comparative body size at age 10	0.4	1.0	1.6	-1.0	-1.3	-0.6
Number of full brothers	2.0	2.5	4.4	-0.2	-1.7	-2.1
Worry too long after embarrassment	0.7	1.2	2.1	1.4	-1.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	0.3	0.5
Wheeze or whistling in the chest in last year	0.9	1.6	3.4	0.3	-1.2	1.8
Number of children fathered	0.9	1.0	2.2	0.8	-1.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.7	0.9	-0.7	-1.3
Age at first live birth	0.6	1.1	2.1	0.6	-1.4	1.0
Pulse wave peak to peak time	0.5	0.6	1.4	-0.3	-1.2	-0.4
Health satisfaction	0.2	0.2	0.7	-0.1	0.8	-0.0
Shortness of breath walking on level ground	3.0	3.6	6.0	-0.9	-1.9	2.5
Qualifications: College or University degree	1.5	4.9	11.7	3.4	0.4	1.7
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.4	0.6	-0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.8	0.3	0.7	-1.3
Emphysema/chronic bronchitis	0.5	0.5	0.7	-0.8	0.6	-0.8
Medication for pain relief, constipation, heartburn	1.1	1.8	4.2	0.3	1.1	2.1
Neck or shoulder pain in last month	0.5	0.8	2.1	0.3	0.3	-1.4
Medication: Blood pressure	0.2	0.4	1.1	-0.1	1.0	-0.2
Angina (self-reported)	1.1	1.4	3.3	-1.8	-0.3	-0.9
Migraine (self-reported)	0.7	0.9	1.9	-0.7	-0.5	-1.4
Medication: Ibuprofen	2.0	2.4	4.6	-1.4	0.7	-2.1
Medication: Allopurinol	0.2	0.3	0.7	0.8	0.0	-0.4
Medication: Omeprazole	0.2	0.2	0.5	-0.3	0.0	-0.7
Medication: Seretide 50 evohaler	2.3	2.7	4.3	-0.8	-2.1	1.7
Mean time to correctly identify matches	0.9	1.7	3.6	-1.1	-0.3	1.9
Heart disease (mother)	1.6	1.9	4.4	2.1	1.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.2	0.5	-0.3
Whole body fat mass	0.4	1.9	2.3	-1.5	-1.1	-1.4
Leg fat mass (right)	0.7	2.6	5.3	-1.2	-1.0	-2.3
Arm predicted mass (right)	0.1	0.7	1.1	-1.0	-0.3	-1.0
Pulse rate, automated reading	1.9	6.1	14.0	-2.0	3.7	0.5
Alcohol intake frequency.	0.8	1.8	5.2	-2.3	0.2	-0.4
Comparative height size at age 10	0.5	3.0	8.2	-2.9	-0.3	0.8
Number of full sisters	1.4	1.6	2.8	-0.3	-1.4	1.7
Suffer from ‘nerves’	0.3	0.5	0.7	-0.7	-0.9	0.4
Overall health rating	0.1	0.3	0.7	-0.8	-0.2	-0.5
Chest pain or discomfort	0.5	0.7	0.9	-1.0	-0.7	0.8
Had major operations	1.2	1.4	2.9	-1.7	-0.5	-0.9
Age at last live birth	0.7	1.0	2.8	0.3	-1.7	0.3
Family relationship satisfaction	0.3	0.4	1.0	-1.0	0.1	0.5
Leg pain on walking	2.9	3.6	8.1	-2.8	-1.1	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.8	-0.7	-1.3	-0.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.7	0.6	1.6	-1.3
Illness, injury, bereavement, stress in last 2 years	2.2	2.6	7.1	0.2	0.9	2.7
Medication: Aspirin	0.2	0.3	0.6	0.5	0.3	-0.8
Supplements: Vitamin C	2.0	2.4	5.9	2.4	1.0	-0.3
Knee pain experienced in last month	0.1	0.1	0.2	0.1	0.1	-0.5
Hypertension (Self-reported)	0.5	1.3	3.9	2.0	0.3	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	3.6	-1.9	0.7	-1.6
Illnesses of father: Heart disease	2.2	3.0	5.6	1.6	2.4	-0.9
Illnesses of siblings: Diabetes	1.6	2.0	3.4	-1.8	0.2	-1.6
Smoking status: Previous	0.1	0.1	0.2	0.2	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.6	3.5	-0.7	0.8	-1.9
Whole body fat-free mass	0.1	0.4	0.8	-0.9	-0.5	-0.3
Leg fat-free mass (right)	0.1	0.8	1.1	-1.1	-0.7	0.8
Arm fat percentage (left)	0.4	1.6	2.1	-1.4	-1.5	-0.8
Average weekly red wine intake	1.4	2.1	4.9	2.2	-0.9	0.8
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.4	-1.5	1.1	-1.1
Mood swings	1.0	1.8	3.5	-1.4	-1.9	0.3
Loneliness, isolation	1.7	2.4	5.6	-0.2	-1.3	2.4
Long-standing illness, disability or infirmity	1.0	1.6	2.9	-1.7	-0.8	-1.1
Ever had bowel cancer screening	3.3	3.8	6.7	-2.6	-2.0	0.9
Diabetes diagnosed by doctor	1.1	1.9	4.2	-0.2	1.2	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.2	1.8	-0.6	-0.6
Friendships satisfaction	0.3	0.4	0.6	-0.0	-0.7	0.8
Qualifications: nursing, teaching	0.4	0.6	1.0	1.0	-0.5	0.8
Commuting to job workplace: Walk	3.0	3.2	9.4	-0.2	-3.1	0.5
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.2	0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.4	1.5	0.3	1.1
Medication for cholesterol	1.8	2.7	7.8	-2.8	0.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.4	-1.9	0.4	0.0
Back pain experienced in last month	1.3	1.9	5.4	-0.4	-0.5	-2.3
Mineral and other dietary supplements	2.0	2.6	7.5	-2.7	-0.3	0.6
Breast cancer (self-reported)	0.1	0.1	0.2	-0.3	-0.0	0.4
Asthma (self-reported)	1.2	2.3	4.2	-0.9	-2.0	1.4
Osteoporosis (self-reported)	1.0	1.3	2.0	-1.3	-0.4	1.4
Osteoarthritis (self-reported)	0.4	0.5	1.4	0.2	1.2	0.5
Medication: Aspirin	0.1	0.1	0.3	0.3	-0.1	-0.6
Medication: Gliclazide	0.5	0.5	1.3	-0.5	-0.3	-1.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.9	-0.8	-0.5	1.4
Smoking status: Current	0.1	0.2	0.5	0.0	0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	7.8	0.4	2.8	0.4
Whole body water mass	0.1	0.4	0.6	-0.8	-0.6	-0.3
Leg predicted mass (right)	0.1	0.8	1.0	-1.0	-0.8	0.8
Arm fat mass (left)	0.5	2.1	2.2	-1.4	-1.5	-1.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	-0.2	-1.0	-0.1
Average weekly champagne plus white wine intake	1.6	2.2	4.7	2.2	0.4	-1.3
Miserableness	2.6	4.5	10.5	-1.5	-3.2	0.9
Guilty feelings	0.5	0.7	0.9	0.9	-0.7	0.9
Wears glasses or contact lenses	0.7	0.8	2.2	-0.3	-1.5	-0.3
Ever taken oral contraceptive pill	0.1	0.2	0.5	-0.1	-0.7	0.1
Hearing aid user	0.8	0.9	2.0	-1.4	-0.4	-0.7
Mother’s age at death	0.2	0.2	0.5	0.7	0.4	-0.2
Financial situation satisfaction	0.0	0.1	0.1	0.2	0.1	-0.3
Tinnitus: Yes, now most or all of the time	1.0	1.1	2.0	1.2	0.2	1.4
Commuting to job workplace: Public transport	1.7	2.0	2.4	-1.6	-1.4	1.3
Eye problems/disorders: Glaucoma	1.4	1.7	4.2	0.3	-0.9	2.0
Medication: Blood pressure	1.0	1.9	4.5	2.1	-1.1	0.0
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.6	1.3	-1.6	-0.2
Supplements: Fish oil (including cod liver oil)	5.1	6.7	19.4	4.4	-0.5	-0.5
High cholesterol (Self-reported)	0.5	1.0	1.6	0.1	1.1	-1.3
Medication: Bendroflumethiazide	0.2	0.3	0.5	0.7	-0.5	-0.2
Medication: Paracetamol	0.1	0.2	0.4	-0.1	-0.6	-0.5
Medication: Lisinopril	1.3	1.6	3.1	1.8	1.3	-0.3
Medication: Atorvastatin	1.5	1.8	3.4	1.1	1.0	-1.8
Illnesses of father: High blood pressure	0.1	0.1	0.2	0.5	-0.0	-0.3
Alcohol drinker status: Never	0.7	0.8	2.2	-0.5	1.5	-0.0
Ever smoked	0.4	0.7	0.9	0.5	-1.0	-0.9
Basal metabolic rate	0.1	0.7	1.2	-1.1	-0.8	-0.6
Leg fat percentage (left)	0.9	3.2	7.0	-1.4	-0.8	-2.6
Arm fat-free mass (left)	0.2	0.9	1.7	-0.9	-0.3	-1.3
Number of operations (self-reported)	0.3	0.4	1.0	-1.0	-0.4	-0.1
Average weekly beer plus cider intake	0.6	0.9	1.4	-1.2	0.9	-0.8
Irritability	0.6	1.0	2.0	-0.8	0.6	1.4
Risk taking	0.1	0.2	0.5	0.7	-0.0	0.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	-1.2	0.8	0.2
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.3	-0.1	-0.6
Age started oral contraceptive pill	0.2	0.3	0.5	-0.3	0.4	0.7
Diastolic blood pressure, automated reading	0.3	1.0	2.4	0.7	0.4	-1.5
Ever depressed for a whole week	0.5	0.6	0.9	0.8	-0.3	-1.0
Unable to work because of sickness or disability	1.4	1.8	3.3	-1.8	-1.2	-0.9
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.4	0.2	0.2
Myopia	0.5	0.7	1.2	-0.4	-1.1	0.9
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.7	-1.9	0.1	-0.6
Cholesterol lowering medication	0.7	1.1	2.9	-0.4	1.7	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.6	0.3	-0.4
Pain experienced in last month	0.9	1.6	4.0	0.5	0.7	2.0
Supplements: Calcium	0.8	0.9	1.0	1.0	0.9	0.9
Basal cell carcinoma (self-reported)	0.4	0.5	0.8	-0.4	-0.8	-0.9
Heart attack/myocardial infarction (self-reported)	1.3	1.7	5.1	-2.3	0.0	0.1
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	6.8	0.0	0.6	-2.6
Heart disease (siblings)	0.9	1.1	1.4	-0.9	1.1	-1.2
Alcohol drinker status: Previous	3.0	3.4	6.8	0.2	-2.6	1.8
Pack years of smoking	0.2	0.2	0.3	-0.5	-0.6	-0.4
Impedance of whole body	0.1	0.4	0.7	-0.8	0.7	0.0
Leg fat mass (left)	0.5	2.1	4.2	-1.3	-0.8	-2.0
Arm predicted mass (left)	0.1	0.6	0.9	-0.9	-0.4	-0.9