Hub : Genes

ARHGAP31

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.4340	0.1160	2.3e-03	-0.013	NA	0.029	NA	0.006	0.9500	NA	6.8e-02	NA	0.22000
2	METSIM	Adipose	0.0457	0.0229	1.8e-02	0.000	0.013	0.004	0.013	0.001	0.3600	3.6e-03	7.3e-02	3.5e-03	0.20000
3	NTR	Blood	0.0286	0.0096	2.8e-04	0.006	0.015	0.017	0.014	0.015	0.0037	1.0e-05	1.9e-06	1.4e-05	0.00001
4	TCGA	Prostate Adenocarcinoma	0.1329	0.0459	2.9e-06	0.017	0.074	0.056	NA	0.028	0.0064	3.8e-08	1.7e-06	NA	0.00063

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	1.6	1.3	0.6	-1.1	0.2
Bipolar Disorder or Schizophrenia	0.3	0.8	2.7	0.7	-0.2	-1.6	0.2
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.0	-0.2	-0.3	0.1
Depression (Nagel 2018)	1.0	1.5	2.4	-0.7	-1.4	-1.1	-1.6
Intelligence (Savage-Jansen 2018)	1.7	5.1	15.3	0.5	3.9	-1.7	1.4
Neuroticism (Nagel 2018)	0.4	0.9	2.4	1.1	-0.3	-1.5	-0.3
Schizophrenia (2018)	0.2	0.5	1.4	-0.1	-0.7	-1.2	0.1
Schizophrenia vs Biploar Disorder	1.1	1.4	3.5	-1.1	-1.1	1.9	0.0
Worry (Nagel 2018)	0.2	0.5	1.3	0.7	-0.6	-1.1	-0.2
Alzheimer’s Disease (in mother)	0.8	0.9	1.8	0.7	-0.4	-1.3	-1.2
Alzheimer’s Disease (in father)	0.9	1.0	2.3	-0.4	-1.5	0.3	-1.1
Alzheimer’s Disease (including proxy)	2.0	2.9	6.5	0.6	-1.7	-1.3	-2.6
Crohns Disease (2017)	0.6	1.3	2.7	0.5	-1.6	-0.5	-1.4
Irritable Bowel Disease (IBD)	0.6	1.4	2.8	0.5	-1.7	0.2	-1.6
Ulcerative Colitis (UC)	0.5	1.0	2.0	0.3	-1.0	1.0	-1.4
Major Depression (MDD)	0.6	0.8	1.8	0.6	-1.4	0.3	-0.9
Reaction Time	0.3	0.6	1.5	-0.2	0.3	0.9	1.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.7	0.8	2.2	-0.2	0.3
Breast Cancer	0.6	1.5	4.8	0.1	-1.0	-2.2	-0.3
Ovarian Cancer	0.4	0.6	1.6	0.2	-0.6	0.6	1.2
Prostate Cancer	0.8	1.2	4.5	-2.1	0.4	0.1	-0.2
Age at First Birth	1.0	1.5	3.8	0.3	1.1	2.0	1.0
Bipolar Disorder (2011)	0.2	0.2	0.3	-0.5	0.4	-0.5	0.5
Body Mass Index (BMI) (2010)	0.6	0.8	3.2	0.3	0.1	-1.8	-0.1
Coronary Artery Disease (CAD)	1.0	1.1	2.5	1.4	0.0	-1.6	0.5
Crohns Disease (2012)	0.4	0.6	1.1	-0.6	-1.0	-0.1	-1.1
Mean Putamen Volume	0.6	0.7	2.8	-0.3	0.0	-0.2	1.7
Fasting Glucose	1.1	1.3	3.3	-0.6	-0.3	1.2	1.8
HbA1C	0.4	0.5	1.6	0.3	0.1	-1.3	-0.4
HDL Cholesterol	0.4	0.7	2.5	0.5	0.3	1.6	0.4
LDL Cholesterol	0.2	0.3	1.0	-1.0	0.5	0.0	0.2
Lupus	3.2	4.9	14.3	0.0	3.8	-0.1	2.3
Neuroticism (2016)	0.4	0.6	1.5	0.8	1.2	0.3	0.3
Primary Biliary Cirrhosis	8.7	12.4	30.3	0.2	4.3	-1.0	5.5
Rheumatoid Arthritis	2.6	3.6	6.5	1.3	2.5	-2.3	1.0
Schizophrenia (2014)	0.6	1.2	2.0	1.1	-1.1	-1.4	-0.7
Triglycerides	0.5	0.9	1.8	1.0	-1.3	0.7	-0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.9	0.5	0.7	0.7	1.7
Ulcerative Colitis	0.8	1.2	2.8	0.8	-0.5	1.0	-1.7
Blood Eosinophil Count	0.6	4.3	7.4	-2.3	-1.9	1.1	-2.7
Blood Platelet Count	0.4	5.0	13.4	-3.7	0.9	2.4	0.3
Blood Red Count	0.2	1.8	3.5	1.9	0.0	-1.8	-0.8
Blood White Count	1.3	9.8	34.6	-1.4	0.1	5.9	1.6
Heel T-Score	0.3	2.6	6.4	2.5	0.4	-1.3	-1.5
BMI	0.5	2.7	5.8	2.4	1.2	-1.1	1.5
Height	0.2	2.9	9.4	0.5	-3.1	0.4	-1.4
Waist Hip Ratio (WHR)	0.4	1.7	4.0	0.9	0.0	1.4	2.0
Systolic Blood Pressure	0.5	2.7	7.3	0.3	0.7	2.7	1.7
Smoking Status	0.6	1.3	3.8	-1.2	0.1	-2.0	0.1
Allergy or Eczema	1.4	3.6	10.4	1.2	0.8	-1.4	-3.2
Cardiovascular Disease	0.7	2.4	3.8	1.6	0.7	1.6	1.9
Hypothyroidism (self reported)	2.0	4.7	8.2	2.7	1.8	-0.4	2.9
Respiratory disease	1.4	3.1	6.5	1.3	-2.0	0.8	-2.5
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.2	0.2	-0.5	1.1	0.4
Lung FEV1/FVC ratio	0.8	3.9	12.7	-0.3	-0.6	-3.6	-1.5
Lung FVC	0.3	1.7	5.0	-0.5	-1.1	0.6	-2.2
Neuroticism	0.2	0.6	1.1	0.3	0.6	-0.8	1.0
Chronotype (morning person)	1.2	2.7	5.4	-2.3	0.1	-2.3	-0.3
Hair Pigment	0.0	0.7	1.3	-1.2	-0.2	-1.1	-0.3
Tanning	0.1	1.6	2.6	1.4	-1.3	-0.3	-1.6
Hand grip strength (left)	0.4	1.1	2.5	1.6	0.5	-0.6	-1.1
Number of treatments/medications taken	0.2	0.3	0.5	0.3	0.7	-0.4	0.6
Average weekly spirits intake	0.6	0.8	2.2	-0.3	-1.5	0.0	-0.8
Sensitivity / hurt feelings	0.3	0.5	0.8	-0.2	0.9	-0.8	-0.8
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.8	-2.2	0.0	-0.8	-0.5
Hearing difficulty/problems: Yes	1.8	2.7	5.3	2.3	0.6	-2.3	0.1
Relative age of first facial hair	0.8	1.6	3.8	1.3	-0.6	0.7	-1.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.5	-1.6	0.6	-0.1	0.4
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.9	1.2	0.0	-0.9	-1.7
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	0.5	0.2	-1.0	-0.8
Systolic blood pressure, automated reading	0.2	0.7	2.5	0.3	-0.3	1.6	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.3	1.0	0.0	0.4
Angina	0.9	1.1	2.1	-1.4	-1.4	0.5	0.6
Medication for hormone replacement therapy	1.1	1.2	2.1	0.8	-1.2	1.4	0.7
Vitamin and mineral supplements	0.4	0.6	1.9	0.5	0.3	1.4	0.4
Supplements: Zinc	1.5	1.6	3.5	-0.4	0.6	-1.9	1.6
Medication: Co-codamol	0.5	0.6	1.7	1.3	-0.4	0.8	-0.1
Medication: Metformin	0.4	0.5	1.2	-0.2	1.1	0.2	1.0
Diabetes (father)	1.1	1.4	5.3	0.0	2.3	0.2	0.4
Diabetes (mother)	0.6	0.8	2.3	-0.3	-1.5	0.7	-0.4
Severe depression (siblings)	1.2	1.4	3.4	-0.7	0.0	-1.8	-1.2
Pack years adult smoking proportion	0.3	0.5	1.2	-0.7	0.5	1.1	-0.4
Impedance of leg (right)	0.7	3.3	6.6	-2.6	-1.1	2.3	0.6
Leg fat-free mass (left)	0.2	0.9	2.5	1.6	0.4	-0.9	0.1
Trunk fat percentage	0.3	1.2	3.2	1.8	-0.3	0.9	0.9
Hand grip strength (right)	0.2	0.5	1.5	0.3	1.2	0.7	-0.3
Townsend deprivation index at recruitment	0.9	1.3	4.9	-2.2	0.3	-0.3	0.1
Current tobacco smoking	1.0	1.7	4.6	-2.1	-1.3	-0.2	-0.5
Average weekly fortified wine intake	0.1	0.1	0.5	0.1	0.7	-0.2	0.2
Maternal smoking around birth	0.2	0.3	0.8	-0.3	0.3	-0.2	0.9
Fed-up feelings	1.1	2.0	6.0	-2.5	-0.5	1.0	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	3.8	-1.9	-1.6	-1.3	-1.8
Relative age voice broke	0.4	0.6	1.0	0.1	-1.0	1.0	-0.7
Taking other prescription medications	0.4	0.7	1.7	0.4	-0.2	-0.9	-1.3
Age when periods started (menarche)	0.3	0.8	2.4	-0.6	-0.7	-1.6	-0.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.8	-0.6	1.7	0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.0	0.3	0.7	-0.9	-1.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	3.0	-1.2	0.5	-1.7	-0.8
Qualifications: CSEs or equivalent	2.8	3.6	6.8	-2.0	1.3	1.4	2.6
Serious illness, injury or assault to yourself	0.8	0.9	1.8	0.3	0.2	-1.4	-1.3
High blood pressure	0.7	1.9	3.8	1.9	1.1	0.8	1.4
Hayfever, allergic rhinitis or eczema	1.4	2.9	10.7	-0.5	0.2	-0.9	-3.3
Multivitamins +/- minerals	1.2	1.5	3.3	-0.1	0.5	-1.6	1.8
Stomach or abdominal pain in last month	0.9	1.1	3.1	-1.1	0.6	-0.0	-1.8
Supplements: Glucosamine	0.1	0.1	0.3	0.5	0.1	0.4	-0.2
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.2	1.5	1.2	-1.8	-0.1
Medication: Atenolol	0.8	1.0	2.0	-0.1	0.2	1.3	1.4
Medication: Levothyroxine sodium	2.3	3.9	9.8	1.7	1.4	-1.1	3.1
Sitting height	0.2	1.7	3.6	1.2	1.9	0.8	1.1
Chronic bronchitis/emphysema (father)	1.0	1.1	1.9	-1.1	-1.1	-0.4	-1.4
High blood pressure (mother)	2.0	2.8	9.8	-0.5	1.0	3.1	0.5
Body mass index (BMI)	0.2	0.9	3.2	1.8	0.1	-0.4	0.2
Impedance of leg (left)	0.8	3.7	8.5	-2.1	-1.2	2.9	0.7
Leg predicted mass (left)	0.1	0.8	2.4	1.6	0.3	-0.8	0.1
Trunk fat mass	0.3	1.3	3.7	1.9	-0.3	0.8	0.8
Waist circumference	0.3	0.9	3.0	1.7	-0.8	0.2	0.2
Number of incorrect matches in round	0.3	0.6	1.3	1.1	-0.5	0.8	0.0
Past tobacco smoking	0.6	1.2	2.1	-0.2	-1.4	1.4	-0.8
Alcohol usually taken with meals	0.6	0.9	2.9	1.7	-0.0	-0.8	-0.0
Nervous feelings	0.3	0.6	2.2	0.3	0.3	-0.1	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	5.9	-2.4	-0.1	0.6	-0.3
Hearing difficulty/problems with background noise	1.7	2.8	6.0	0.0	1.9	-2.4	1.1
Hair/balding pattern: Pattern 2	0.7	0.8	1.7	-0.1	-0.2	-1.2	1.3
Had menopause	0.7	0.9	3.0	1.7	-0.6	-0.4	-0.3
Had other major operations	1.1	1.3	2.3	-1.5	1.4	-0.4	0.8
Forced vital capacity (FVC)	0.3	1.2	2.0	-1.4	-0.9	1.2	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.8	0.9	0.4	-1.3	-0.8
Ever unenthusiastic/disinterested for a whole week	1.8	2.3	5.5	-0.5	-2.4	-0.1	-1.8
Qualifications: None of the above	0.1	0.1	0.3	-0.2	-0.6	0.0	-0.2
Financial difficulties in last 2 years	1.3	1.8	5.9	-1.1	0.3	-2.4	0.3
Mouth/teeth dental problems	0.6	0.9	2.0	-0.1	0.4	1.2	1.4
Heart attack	0.3	0.4	1.0	1.0	0.7	0.0	-0.1
Allergy	2.0	4.6	16.1	0.1	0.3	1.5	4.0
Pain all over the body in last month	0.1	0.1	0.2	0.5	0.1	0.2	-0.1
Diabetes (self-reported)	0.1	0.1	0.3	0.5	0.2	-0.1	0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.5	1.0	0.1	0.8	-1.2
Medication: Ramipril	0.7	0.9	1.6	1.3	-0.1	0.7	1.2
Medication: Simvastatin	0.2	0.3	0.4	-0.1	-0.6	-0.6	-0.7
Fluid intelligence score	1.0	2.1	7.9	0.1	2.8	0.4	0.7
Illnesses of siblings	0.2	0.3	0.9	0.0	0.6	0.9	0.1
Neuroticism score	0.2	0.5	1.1	-0.5	0.8	-0.0	1.0
Weight	0.2	0.8	3.1	1.8	-0.4	0.0	-0.0
Impedance of arm (right)	0.2	1.0	1.8	-1.2	-0.1	1.4	0.7
Arm fat percentage (right)	0.2	0.9	3.0	1.7	0.1	0.4	0.8
Trunk fat-free mass	0.1	0.4	0.6	0.8	-0.4	-0.7	-0.6
Hip circumference	0.1	0.6	1.6	1.3	-0.5	-0.7	-0.3
Time employed in main current job	1.2	1.4	5.2	-0.6	-2.3	-0.2	-0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.3	-0.8	-0.6	-0.1
Father’s age at death	1.5	2.0	6.4	-0.7	2.5	0.0	1.0
Worrier / anxious feelings	0.5	0.9	1.8	-1.2	-0.0	-1.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	-0.4	-0.2	-0.1	-0.3
Falls in the last year	1.2	1.6	2.5	1.5	1.0	-1.6	0.7
Hair/balding pattern: Pattern 3	0.6	0.8	1.6	-1.0	1.3	0.8	-0.0
Number of live births	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	-1.0	-1.0	0.2	-0.9
Pulse rate	1.4	2.4	4.0	-0.6	1.3	1.9	2.0
Happiness	0.3	0.4	0.9	-1.0	0.0	0.7	-0.4
Noisy workplace	0.2	0.3	0.5	0.5	0.3	-0.7	0.5
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.9	-0.3	2.0	-0.2	2.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	3.4	-1.8	0.6	1.8	0.4
Mouth/teeth dental problems: Dentures	0.9	1.6	4.8	0.1	1.2	-2.2	0.2
Asthma	1.1	2.1	7.4	0.5	-0.7	-0.4	-2.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.0	1.4	1.1	-0.7	0.2
Medication: Cholesterol lowering	0.5	0.8	1.3	-0.9	0.5	-1.1	-0.9
Depression (self-reported)	0.3	0.3	0.9	-0.2	-0.9	0.2	-0.7
Medication: Lansoprazole	0.5	0.6	1.1	0.4	1.1	-0.8	0.6
Prospective memory result	0.5	0.6	0.7	-0.8	-0.8	0.8	0.5
Lung cancer (father)	0.4	0.4	1.4	-0.3	1.2	-0.2	0.4
Illnesses of mother	0.1	0.2	0.3	-0.2	-0.6	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.9	-0.0	-0.7	-0.1	-0.9
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	0.5	-0.4	0.2	0.8
Impedance of arm (left)	0.3	1.3	4.1	-0.5	0.8	2.0	0.6
Arm fat mass (right)	0.2	0.9	3.2	1.8	0.0	0.0	0.5
Trunk predicted mass	0.1	0.4	0.7	0.9	-0.5	-0.7	-0.5
Standing height	0.0	0.4	0.8	0.4	-0.8	0.9	-0.1
Length of working week for main job	1.1	1.2	2.7	-1.6	-0.5	1.2	-0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.2	-0.1	-0.4	-0.1
Breastfed as a baby	0.5	0.7	2.3	1.5	-0.1	-0.5	-0.4
Tense / ‘highly strung’	0.5	0.8	1.4	-0.7	0.9	0.5	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.1	1.1	-0.5	-0.8	1.5
Hair/balding pattern: Pattern 4	0.2	0.5	1.9	-0.0	1.4	-0.4	-0.3
Birth weight of first child	0.5	0.9	1.7	-0.8	-1.3	-1.0	-0.4
Peak expiratory flow (PEF)	0.1	0.3	0.8	0.9	-0.7	-0.2	0.2
Pulse wave reflection index	0.4	0.4	1.3	-0.4	-1.2	-0.2	-0.4
Ever highly irritable/argumentative for 2 days	1.5	1.8	2.1	-1.3	-1.4	1.3	-1.3
Loud music exposure frequency	0.4	0.4	1.2	0.4	-0.5	1.1	-0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.7	-0.5	0.9	-0.4	1.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.9	0.3	0.2	-1.1	-2.0
Blood clot in the leg (DVT)	0.3	0.4	0.7	-0.8	-0.2	0.7	-0.6
Medication: Paracetamol	0.3	0.5	1.1	0.9	-1.0	-0.3	-0.4
Headache pain in last month	0.2	0.4	0.9	-0.8	0.2	-0.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.7	-0.2	-0.1	1.3	-0.2
Glaucoma (self-reported)	0.7	0.8	2.5	-0.3	-0.2	-0.7	-1.6
Gout (self-reported)	2.3	3.1	4.8	-1.5	1.5	2.2	1.8
Hypothyroidism/myxoedema (self-reported)	2.3	4.5	8.1	2.3	2.2	-0.5	2.8
Medication: Amlodipine	0.3	0.4	1.3	0.0	0.1	-0.5	1.1
Medication: Ventolin 100micrograms inhaler	1.9	2.4	6.8	0.2	-1.7	0.1	-2.6
Birth weight	0.2	0.3	0.9	-0.3	0.4	-0.5	-1.0
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.8	-0.2	-0.6	0.1	-1.3
High blood pressure (siblings)	0.2	0.3	0.4	-0.2	0.6	-0.5	0.6
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	-0.4	-0.4	0.9	-0.6
Body fat percentage	0.3	1.3	3.5	1.9	-0.5	0.9	0.7
Leg fat percentage (right)	0.1	0.5	1.3	1.1	-0.9	0.2	-0.1
Arm fat-free mass (right)	0.1	0.6	2.3	1.5	-0.2	-0.1	-0.3
Exposure to tobacco smoke outside home	0.8	1.1	4.0	0.5	0.1	-2.0	-0.4
Comparative body size at age 10	0.6	1.7	3.2	0.7	1.2	-1.8	1.4
Number of full brothers	1.4	1.7	5.1	-0.1	0.6	-1.2	-2.3
Worry too long after embarrassment	0.4	0.7	1.5	0.8	0.7	-1.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.8	0.8	-0.4	-0.6	0.9
Wheeze or whistling in the chest in last year	0.6	1.1	3.4	-0.5	-0.5	0.6	-1.8
Number of children fathered	1.8	2.0	5.1	2.3	0.4	-1.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	0.3	0.8	-0.2	0.0
Age at first live birth	0.5	0.9	2.9	0.2	1.7	-0.7	0.4
Pulse wave peak to peak time	0.2	0.3	0.8	-0.4	0.3	-0.2	-0.9
Health satisfaction	0.5	0.7	1.9	-0.4	-0.7	-0.4	-1.4
Shortness of breath walking on level ground	0.9	1.1	1.9	1.4	1.4	0.2	0.7
Qualifications: College or University degree	0.5	1.7	3.4	1.8	1.3	-0.6	-1.1
Eye problems/disorders: None of the above	0.9	1.0	2.0	1.1	-0.3	1.4	0.9
Mouth/teeth dental problems: Loose teeth	2.0	2.4	7.8	-0.2	-0.7	-2.8	-1.2
Emphysema/chronic bronchitis	0.4	0.5	0.7	0.7	-0.1	0.8	0.9
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.5	-0.2	0.7	0.3
Neck or shoulder pain in last month	0.8	1.2	1.7	1.1	0.9	-1.3	-1.0
Medication: Blood pressure	0.4	0.6	2.2	1.5	0.2	0.1	0.5
Angina (self-reported)	0.9	1.1	1.7	-1.3	-1.2	0.5	1.1
Migraine (self-reported)	0.8	1.0	2.2	0.3	1.5	-0.8	1.1
Medication: Ibuprofen	0.5	0.6	1.4	1.2	0.8	0.0	0.3
Medication: Allopurinol	0.7	1.0	2.2	-1.0	0.7	1.5	0.6
Medication: Omeprazole	1.3	1.5	3.7	-0.6	0.7	-1.9	1.2
Medication: Seretide 50 evohaler	1.7	2.0	3.2	1.8	1.3	-0.7	1.7
Mean time to correctly identify matches	0.1	0.2	0.7	0.2	-0.8	0.2	0.2
Heart disease (mother)	0.7	0.9	2.2	-0.0	0.3	-1.5	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.6	0.1	-0.0	-0.6
Whole body fat mass	0.3	1.1	3.8	1.9	-0.2	0.4	0.6
Leg fat mass (right)	0.2	0.6	2.3	1.5	-0.3	0.2	0.2
Arm predicted mass (right)	0.1	0.7	2.6	1.6	-0.1	-0.4	-0.2
Pulse rate, automated reading	0.2	0.7	1.8	0.3	-0.6	1.4	0.7
Alcohol intake frequency.	0.6	1.3	2.8	0.3	-1.7	0.2	-1.5
Comparative height size at age 10	0.7	3.6	9.4	3.1	-1.6	0.6	-1.5
Number of full sisters	1.0	1.2	2.3	-1.2	-0.5	1.5	-1.0
Suffer from ‘nerves’	0.1	0.2	0.5	0.2	0.1	-0.5	0.7
Overall health rating	0.9	1.9	5.1	-2.3	-0.5	1.4	-0.5
Chest pain or discomfort	0.3	0.5	1.0	-0.9	1.0	0.4	0.0
Had major operations	1.0	1.2	4.5	2.1	0.1	-0.5	-0.1
Age at last live birth	0.5	0.7	1.9	1.4	0.7	-0.4	0.6
Family relationship satisfaction	1.4	1.7	3.8	-0.8	0.2	-1.9	-1.5
Leg pain on walking	1.1	1.4	2.1	1.3	0.0	-1.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.4	-1.0	-1.6	0.4	-0.2
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.0	1.3	1.4	-0.5	1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	0.3	-1.2	0.3	-0.8
Medication: Aspirin	0.6	0.8	1.8	0.6	-1.4	-0.1	-0.9
Supplements: Vitamin C	1.2	1.4	3.5	0.4	0.6	-1.9	-1.2
Knee pain experienced in last month	0.6	0.9	1.9	-1.0	-0.9	-0.1	-1.4
Hypertension (Self-reported)	0.5	1.4	2.7	1.6	0.9	1.1	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.6	1.4	-1.2	-0.1	-0.5	0.9
Illnesses of father: Heart disease	0.6	0.8	1.4	1.2	0.4	-1.2	-0.5
Illnesses of siblings: Diabetes	1.5	1.8	3.8	0.0	-1.8	-0.5	-2.0
Smoking status: Previous	0.3	0.4	0.8	0.2	0.9	-0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.7	-0.4	-0.3	0.4
Whole body fat-free mass	0.1	0.5	1.3	1.2	-0.1	-0.7	-0.2
Leg fat-free mass (right)	0.2	1.0	3.2	1.8	0.5	-0.5	0.3
Arm fat percentage (left)	0.4	1.5	4.6	2.1	0.5	0.9	0.7
Average weekly red wine intake	0.4	0.6	1.6	0.2	-0.9	1.2	0.3
Handedness (chirality/laterality): Left-handed	1.3	1.5	2.8	1.4	-1.7	0.6	-1.0
Mood swings	0.2	0.4	0.9	0.5	-0.2	0.9	0.6
Loneliness, isolation	1.3	1.9	3.2	-1.8	0.0	-1.0	-1.8
Long-standing illness, disability or infirmity	0.1	0.1	0.4	-0.7	0.0	-0.1	0.3
Ever had bowel cancer screening	1.3	1.5	3.5	-1.9	1.5	-0.5	-0.4
Diabetes diagnosed by doctor	0.0	0.0	0.0	0.1	-0.1	0.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.6	11.1	0.8	-0.5	-3.3	-1.5
Friendships satisfaction	0.1	0.1	0.3	-0.5	0.0	0.2	-0.6
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.6	0.4	0.5	-0.2
Commuting to job workplace: Walk	0.5	0.6	1.5	-0.6	-0.7	1.2	0.3
Eye problems/disorders: Cataract	0.7	0.8	1.9	-1.1	0.0	-1.4	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.3	1.0	-2.1	-0.4	-0.1
Medication for cholesterol	1.1	1.7	3.2	-1.3	0.4	-1.3	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.3	-1.1	-0.3	-0.0	1.1
Back pain experienced in last month	3.1	4.6	11.1	2.4	-0.5	-1.1	-3.3
Mineral and other dietary supplements	1.0	1.3	2.0	0.6	-1.4	1.4	-0.9
Breast cancer (self-reported)	0.3	0.4	1.3	-0.2	0.4	-0.4	1.1
Asthma (self-reported)	0.9	1.8	6.9	0.4	-0.5	-0.0	-2.6
Osteoporosis (self-reported)	1.2	1.5	4.1	-2.0	-0.4	-0.2	1.2
Osteoarthritis (self-reported)	0.2	0.3	1.0	-0.3	-1.0	0.1	-0.5
Medication: Aspirin	1.0	1.3	3.2	0.3	-1.8	0.4	-1.4
Medication: Gliclazide	0.4	0.4	1.2	-1.1	0.3	-0.0	0.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	-0.1	-1.2	0.4	-0.4
Smoking status: Current	0.7	1.2	2.9	-1.7	-1.1	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	5.6	-0.4	-1.4	-0.5	-2.4
Whole body water mass	0.1	0.7	1.8	1.3	-0.1	-0.9	-0.2
Leg predicted mass (right)	0.2	0.9	3.1	1.8	0.5	-0.5	0.3
Arm fat mass (left)	0.3	1.4	4.7	2.2	0.3	0.4	0.8
Number of self-reported non-cancer illnesses	0.4	0.7	1.5	-0.2	1.2	-1.2	-0.2
Average weekly champagne plus white wine intake	0.9	1.2	2.6	1.1	-0.6	-1.6	-0.9
Miserableness	0.4	0.7	1.3	-0.5	1.0	0.3	1.1
Guilty feelings	1.0	1.4	2.3	0.4	1.5	-1.1	1.4
Wears glasses or contact lenses	0.4	0.5	0.7	0.7	-0.8	-0.8	-0.5
Ever taken oral contraceptive pill	1.4	1.6	5.5	2.4	-0.1	0.7	0.5
Hearing aid user	0.7	0.8	2.2	0.5	0.6	-0.6	1.5
Mother’s age at death	1.0	1.2	2.3	0.1	1.5	-1.0	1.2
Financial situation satisfaction	1.5	1.8	2.8	-0.8	-1.2	-1.5	-1.7
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.2	1.2	-1.5	-0.4	-0.7
Commuting to job workplace: Public transport	0.3	0.4	0.6	-0.5	-0.8	0.7	0.2
Eye problems/disorders: Glaucoma	0.9	1.1	3.1	-0.2	-1.1	0.1	-1.8
Medication: Blood pressure	1.1	2.0	4.2	0.9	1.0	1.5	2.0
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.1	1.1	1.7	-1.8	-0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.9	-0.2	0.7	-1.4	0.9
High cholesterol (Self-reported)	0.6	1.1	2.4	1.1	0.9	-1.5	-0.1
Medication: Bendroflumethiazide	0.6	1.0	3.4	-0.7	0.1	0.2	1.8
Medication: Paracetamol	0.0	0.0	0.1	0.3	-0.3	-0.0	0.0
Medication: Lisinopril	0.4	0.6	1.2	0.8	0.6	1.1	0.3
Medication: Atorvastatin	1.4	1.8	5.3	-0.1	2.3	1.3	0.3
Illnesses of father: High blood pressure	0.7	0.9	1.3	-1.1	1.0	-0.7	0.9
Alcohol drinker status: Never	2.0	2.4	8.5	0.3	-1.0	-0.4	-2.9
Ever smoked	1.0	1.8	3.1	-0.4	1.5	-1.7	1.3
Basal metabolic rate	0.1	0.6	1.9	1.4	-0.2	-0.5	-0.1
Leg fat percentage (left)	0.3	0.9	2.2	1.5	-1.0	0.7	0.1
Arm fat-free mass (left)	0.1	0.7	1.7	1.3	-0.6	-0.8	-0.4
Number of operations (self-reported)	0.7	1.0	1.8	0.3	1.3	-1.2	0.8
Average weekly beer plus cider intake	0.8	1.1	3.3	0.3	-1.8	0.8	-0.7
Irritability	0.7	1.2	3.8	-0.7	-0.7	1.9	-0.1
Risk taking	0.6	0.8	1.4	-0.8	-0.2	-1.1	-1.2
Ever had prostate specific antigen (PSA) test	2.9	3.4	13.4	0.2	-0.2	-3.7	-0.1
Fractured/broken bones in last 5 years	0.7	1.0	1.6	-1.2	0.9	-1.1	0.6
Age started oral contraceptive pill	1.1	1.4	4.2	2.1	-0.5	-0.1	-1.1
Diastolic blood pressure, automated reading	0.3	0.9	2.0	1.0	-0.6	1.4	0.4
Ever depressed for a whole week	1.5	1.8	3.1	-0.8	-1.7	0.7	-1.8
Unable to work because of sickness or disability	0.3	0.3	0.8	-0.5	-0.2	-0.5	0.9
Commuting to job workplace: Cycle	1.6	1.9	4.2	2.0	0.5	-1.7	-0.4
Myopia	0.7	1.0	2.1	0.5	0.7	1.1	1.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.2	-1.3	-0.6	-1.0	-1.5
Cholesterol lowering medication	0.1	0.2	0.5	0.7	-0.4	-0.3	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.1	-0.5	1.1	-2.0	1.0
Pain experienced in last month	1.7	2.9	9.1	-1.1	0.5	1.1	3.0
Supplements: Calcium	2.0	2.2	3.2	-1.7	-0.4	-1.8	-1.6
Basal cell carcinoma (self-reported)	0.7	0.9	1.8	-0.5	0.6	-1.3	-1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.7	1.3	0.6	-0.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.8	-0.7	-0.4	0.7	-0.9
Heart disease (siblings)	0.7	0.8	2.9	-0.3	0.5	-0.2	1.7
Alcohol drinker status: Previous	0.9	1.0	2.5	0.8	0.8	0.2	1.6
Pack years of smoking	0.2	0.4	0.5	-0.5	0.5	0.7	-0.6
Impedance of whole body	0.5	2.7	8.1	-1.4	-0.3	2.8	0.9
Leg fat mass (left)	0.2	0.9	3.2	1.8	-0.4	0.4	0.3
Arm predicted mass (left)	0.1	0.6	0.9	0.9	-0.9	-0.6	-0.5