Hub : Genes

ARHGAP32

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.2280	0.0730	6.2e-04	0.055	NA	0.066	NA	0.073	8.3e-04	NA	2.5e-04	NA	1.2e-04
2	GTEx	Adrenal Gland	0.1893	0.0678	1.3e-03	0.170	NA	0.071	NA	0.145	1.1e-06	NA	1.6e-03	NA	7.0e-06
3	GTEx	Cells Transformed fibroblasts	0.2330	0.0460	3.9e-09	0.161	NA	0.158	NA	0.151	3.9e-12	NA	6.0e-12	NA	2.1e-11
4	GTEx	Heart Atrial Appendage	0.3870	0.0800	1.1e-06	0.183	NA	0.090	NA	0.128	1.2e-08	NA	7.3e-05	NA	2.4e-06
5	GTEx	Nerve Tibial	0.4350	0.0503	0.0e+00	0.394	NA	0.351	NA	0.406	1.3e-29	NA	8.5e-26	NA	1.1e-30
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0422	0.0224	7.6e-04	0.009	0.022	0.016	NA	0.016	2.7e-02	0.0013	5.7e-03	NA	5.8e-03
7	TCGA	Thyroid Carcinoma	0.0580	0.0310	4.9e-03	-0.002	0.015	0.019	NA	0.004	5.6e-01	0.0120	4.9e-03	NA	1.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.7	1.9	-1.4	-1.4	-0.1	0.0	-0.8	0.2	0.6
Bipolar Disorder or Schizophrenia	0.5	1.2	4.6	-1.1	-2.2	-0.5	-0.1	-1.2	0.9	-0.5
Depressed Affect (Nagel 2018)	1.2	2.5	7.6	-2.8	-2.4	0.4	0.8	0.1	0.7	1.7
Depression (Nagel 2018)	0.7	1.1	2.2	-0.3	-1.2	0.9	1.2	1.5	1.3	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.0	0.1	-1.4	0.5	0.2	0.2	0.9	0.2
Neuroticism (Nagel 2018)	0.9	2.1	6.2	-2.5	-2.5	0.4	0.5	0.4	1.0	1.1
Schizophrenia (2018)	0.4	0.8	2.8	-0.2	-1.7	-0.6	-0.1	-1.0	1.0	-0.8
Schizophrenia vs Biploar Disorder	0.8	1.1	3.0	0.6	-0.9	0.5	0.8	0.6	1.7	-1.5
Worry (Nagel 2018)	0.5	1.1	3.4	-1.7	-1.8	0.1	-0.1	-0.0	0.7	0.8
Alzheimer’s Disease (in mother)	0.6	0.7	2.5	-0.7	-1.6	-0.5	-0.1	-0.4	0.7	-0.9
Alzheimer’s Disease (in father)	0.5	0.5	2.4	0.2	1.5	-0.2	0.0	0.0	-0.4	-1.0
Alzheimer’s Disease (including proxy)	0.3	0.4	1.6	-0.4	-0.3	-0.7	-0.3	-0.7	-0.1	-1.3
Crohns Disease (2017)	0.1	0.3	1.1	-1.1	-0.6	-0.1	-0.2	-0.5	0.0	0.2
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	0.0	-0.3	0.0	-0.0	-0.1	0.5	0.1
Ulcerative Colitis (UC)	0.2	0.4	1.5	0.7	-0.3	0.6	0.5	0.5	1.2	0.0
Major Depression (MDD)	0.8	1.0	2.5	0.8	-1.1	0.8	0.4	1.0	1.6	-1.0
Reaction Time	0.2	0.4	1.0	-0.9	-0.4	0.6	1.0	0.4	0.7	-0.3
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.8	1.5	-1.2	1.1	0.6	0.9	1.7	0.5
Breast Cancer	0.2	0.4	0.9	0.7	-0.9	0.4	0.7	0.2	0.7	-0.8
Ovarian Cancer	0.1	0.1	0.4	0.2	0.0	-0.6	-0.2	-0.4	-0.3	0.5
Prostate Cancer	0.9	1.3	2.5	1.0	0.1	1.3	1.1	1.5	1.6	-0.5
Age at First Birth	0.2	0.3	1.8	-1.3	-0.0	-0.2	0.0	0.0	0.0	0.7
Bipolar Disorder (2011)	0.3	0.3	1.3	-1.2	-0.7	0.1	0.3	0.0	-0.3	0.2
Body Mass Index (BMI) (2010)	1.8	2.4	5.8	-2.4	-0.9	-1.7	-1.4	-1.9	-1.2	0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.3	-0.6	0.5	-0.4	-0.3	-0.5	0.4	-0.3
Crohns Disease (2012)	0.3	0.4	1.3	-1.2	-1.0	-0.1	0.0	0.1	0.7	-0.4
Mean Putamen Volume	0.1	0.1	0.3	0.1	0.4	0.1	-0.2	0.6	0.2	-0.2
Fasting Glucose	0.7	0.9	3.6	-0.1	1.9	-0.5	-1.0	0.1	-1.1	-0.3
HbA1C	1.5	1.6	2.3	-0.8	0.9	-1.5	-1.4	-1.5	-1.4	-1.2
HDL Cholesterol	1.0	1.7	5.2	2.3	-0.5	1.0	0.9	1.4	1.7	-0.6
LDL Cholesterol	0.8	1.3	2.2	-1.0	-0.7	-1.1	-1.4	-1.2	-0.7	-1.5
Lupus	0.3	0.5	2.5	0.9	-0.2	-0.0	-0.1	-0.5	0.2	-1.6
Neuroticism (2016)	0.1	0.2	0.5	-0.7	-0.7	-0.3	-0.0	-0.1	-0.4	0.0
Primary Biliary Cirrhosis	0.9	1.3	2.5	-1.0	-0.9	1.6	1.4	1.1	1.1	0.3
Rheumatoid Arthritis	1.6	2.2	3.4	0.6	-1.6	1.7	1.8	1.6	1.6	0.9
Schizophrenia (2014)	0.4	0.9	1.9	-1.2	-1.4	-0.7	-0.4	-1.3	0.7	-0.4
Triglycerides	1.2	2.0	5.7	-2.4	-1.0	-1.0	-0.9	-1.9	-1.4	0.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.7	-1.6	-0.7	-0.1	-0.7	-0.1	0.6	1.5
Ulcerative Colitis	0.4	0.5	1.9	0.1	-0.9	-0.5	-0.0	-0.4	0.8	-1.4
Blood Eosinophil Count	0.3	2.0	4.8	-2.2	1.2	-1.3	-1.0	-1.3	-1.6	-0.5
Blood Platelet Count	1.2	14.4	31.2	1.1	5.2	-3.9	-3.1	-3.0	-5.6	-2.9
Blood Red Count	0.0	0.1	0.3	0.1	-0.5	-0.0	-0.1	0.0	-0.1	-0.3
Blood White Count	0.4	3.1	10.7	-3.3	-3.0	-0.6	-0.7	-1.1	0.2	-0.8
Heel T-Score	0.6	4.4	8.9	-0.7	-0.1	-2.7	-3.0	-2.9	-2.4	-0.6
BMI	0.2	1.2	2.4	1.6	-1.4	0.8	0.2	1.0	1.5	-0.3
Height	2.0	38.6	69.6	3.6	-2.8	8.3	7.9	7.5	6.6	4.3
Waist Hip Ratio (WHR)	0.1	0.6	1.6	0.4	0.5	-1.0	-0.4	-0.9	-1.2	0.4
Systolic Blood Pressure	0.8	4.0	6.6	0.9	2.6	-2.1	-2.2	-1.8	-2.5	-1.4
Smoking Status	0.4	0.9	2.0	-1.1	-0.3	0.9	1.1	0.8	0.4	1.4
Allergy or Eczema	1.7	4.4	9.0	-1.7	2.0	-2.3	-1.6	-1.0	-3.0	-2.4
Cardiovascular Disease	0.1	0.4	1.9	0.3	0.4	0.0	-0.3	0.2	-0.6	1.4
Hypothyroidism (self reported)	0.0	0.1	0.4	-0.6	-0.3	0.0	-0.3	-0.4	-0.1	-0.1
Respiratory disease	1.0	2.2	3.5	-0.4	-1.7	1.9	1.6	1.4	1.9	0.8
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.7	-0.6	-1.9	1.1	1.5	1.1	1.6	1.1
Lung FEV1/FVC ratio	0.3	1.5	2.2	0.8	1.2	-1.5	-1.5	-1.2	-1.1	-1.3
Lung FVC	0.4	1.8	3.5	-0.8	0.9	-1.4	-1.0	-1.2	-1.9	1.8
Neuroticism	0.6	1.5	4.7	-2.2	-1.9	-0.8	-1.0	-0.7	-0.2	0.3
Chronotype (morning person)	0.9	2.1	7.1	1.9	2.7	0.6	1.0	1.0	-0.4	-1.2
Hair Pigment	0.3	9.2	14.9	2.2	1.1	3.9	3.7	3.8	3.7	1.2
Tanning	0.1	1.3	3.5	-1.2	1.9	-0.6	-0.4	-0.6	-1.7	0.3
Hand grip strength (left)	0.2	0.4	1.6	0.8	0.4	0.4	0.3	0.3	0.0	1.3
Number of treatments/medications taken	1.1	2.0	9.9	-1.6	-3.1	0.3	0.1	0.5	1.1	0.3
Average weekly spirits intake	0.9	1.1	2.6	0.5	-1.6	0.9	0.3	1.1	1.6	0.4
Sensitivity / hurt feelings	1.0	1.7	5.1	-2.3	-2.1	0.7	0.7	0.4	1.1	0.2
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.5	-1.0	-1.9	1.4	1.8	1.5	1.4	0.8
Hearing difficulty/problems: Yes	2.5	3.8	8.9	-0.1	2.5	-2.0	-2.1	-1.8	-3.0	-0.1
Relative age of first facial hair	0.4	0.8	2.0	-0.8	0.4	-1.0	-1.4	-0.9	-0.5	-0.8
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.3	0.1	-0.4	1.8	1.6	1.9	2.1	1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.3	-1.5	-0.0	-0.3	0.0	-0.8	-1.2	0.0
Ever had hysterectomy (womb removed)	0.8	1.0	1.9	-0.3	-0.5	1.4	1.3	1.1	0.6	1.0
Systolic blood pressure, automated reading	0.5	1.5	2.3	1.2	1.2	-1.3	-1.5	-0.8	-1.5	-0.8
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.1	-0.2	-0.8	1.5	2.0	1.8	1.4	-0.3
Angina	0.6	0.8	2.8	-1.7	-0.8	0.5	0.5	0.4	1.0	0.3
Medication for hormone replacement therapy	0.2	0.2	0.8	0.7	-0.4	-0.0	0.5	0.0	0.1	-0.9
Vitamin and mineral supplements	2.0	2.7	5.3	2.0	1.6	1.7	1.6	2.3	1.1	0.1
Supplements: Zinc	0.6	0.6	1.0	-0.2	-1.0	-0.9	-1.0	-1.0	-0.5	0.5
Medication: Co-codamol	1.9	2.2	4.5	-1.0	-1.4	1.8	1.8	1.2	2.1	0.6
Medication: Metformin	0.8	1.1	4.4	-0.1	-2.1	0.5	0.6	0.6	1.6	0.2
Diabetes (father)	1.9	2.4	4.6	0.4	2.1	-1.6	-1.5	-1.4	-1.8	-1.4
Diabetes (mother)	0.9	1.1	1.8	-0.9	0.3	-1.1	-0.9	-1.2	-1.3	1.4
Severe depression (siblings)	0.6	0.7	3.7	-0.4	0.1	-0.5	-0.9	-0.2	-0.3	-1.9
Pack years adult smoking proportion	0.6	0.9	1.6	-0.1	0.3	-1.3	-0.7	-1.2	-1.1	-1.2
Impedance of leg (right)	0.7	3.2	7.6	-1.6	2.4	-1.7	-1.0	-1.5	-2.8	-0.5
Leg fat-free mass (left)	1.8	9.6	17.5	3.1	-2.1	3.7	3.1	3.3	4.2	0.9
Trunk fat percentage	0.1	0.4	0.9	0.9	-0.3	0.2	0.3	0.7	0.5	-1.0
Hand grip strength (right)	0.3	0.9	5.2	0.3	-0.2	0.9	0.6	0.1	-0.0	2.3
Townsend deprivation index at recruitment	0.5	0.7	3.0	-1.7	-0.1	-0.2	0.4	-0.7	-0.7	0.7
Current tobacco smoking	0.5	0.8	2.6	-1.6	0.1	-0.8	-0.3	-1.0	-1.2	0.3
Average weekly fortified wine intake	1.0	1.2	2.4	-0.9	-1.6	-1.0	-1.1	-1.1	-0.6	1.2
Maternal smoking around birth	1.7	2.5	5.6	-2.4	-0.9	-1.6	-1.6	-2.1	-1.3	0.1
Fed-up feelings	0.6	1.0	2.8	-1.6	-1.7	0.4	0.6	0.6	0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.7	-0.3	0.4	-0.6	0.1	0.0	-0.8	-0.6
Relative age voice broke	0.3	0.4	1.2	-0.1	-0.2	1.1	0.5	0.7	0.9	0.3
Taking other prescription medications	2.1	3.3	9.8	-3.0	-3.1	0.2	0.4	0.3	0.8	1.8
Age when periods started (menarche)	1.6	3.8	7.3	1.1	2.7	-2.2	-1.8	-1.6	-1.8	-2.0
Bilateral oophorectomy (both ovaries removed)	2.7	3.2	5.2	0.7	-0.6	2.1	2.3	2.3	2.0	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.9	0.4	1.0	-0.8	-0.7	-0.7	-1.4	0.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.3	-1.1	0.2	-1.5	-1.3	-1.1	-1.5	-0.6
Qualifications: CSEs or equivalent	0.2	0.2	0.9	0.6	1.0	-0.5	-0.1	0.0	-0.0	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.4	-0.5	-0.1	0.2	0.2	-0.1	0.3
High blood pressure	0.1	0.1	0.6	0.3	0.2	0.1	0.0	0.3	-0.5	0.8
Hayfever, allergic rhinitis or eczema	2.1	4.5	8.1	-1.4	1.8	-2.5	-1.7	-1.6	-2.9	-2.6
Multivitamins +/- minerals	2.3	2.9	6.6	-1.9	-2.6	-1.6	-1.4	-2.1	-0.7	-0.7
Stomach or abdominal pain in last month	1.4	1.8	3.3	-1.1	0.6	-1.5	-1.6	-1.1	-1.1	-1.8
Supplements: Glucosamine	1.6	2.1	3.5	-1.7	-0.9	-1.7	-1.7	-1.9	-0.9	-0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.4	0.4	1.9	0.2	-0.2	-0.3	-1.1	0.4
Medication: Atenolol	0.1	0.2	0.5	-0.2	0.7	-0.2	0.2	-0.3	-0.5	-0.5
Medication: Levothyroxine sodium	0.2	0.4	0.6	0.8	0.6	-0.4	-0.8	-0.3	-0.6	-0.5
Sitting height	2.1	14.9	25.9	3.9	-0.7	5.1	4.6	4.4	4.7	0.7
Chronic bronchitis/emphysema (father)	0.9	1.1	3.7	1.9	1.5	0.0	-0.2	0.5	-0.8	-0.8
High blood pressure (mother)	0.4	0.6	1.6	0.1	1.3	-0.6	-0.8	-0.7	-0.7	-0.6
Body mass index (BMI)	0.2	1.0	2.2	1.0	-1.5	0.5	0.2	0.8	1.4	-0.9
Impedance of leg (left)	0.8	3.7	8.3	-1.8	2.4	-2.0	-1.2	-1.7	-2.9	-0.7
Leg predicted mass (left)	1.8	9.4	17.2	3.0	-2.1	3.7	3.1	3.3	4.1	0.9
Trunk fat mass	0.4	1.9	2.9	1.6	-1.1	1.4	1.2	1.6	1.7	-0.6
Waist circumference	0.5	1.9	3.3	1.6	-1.4	1.3	1.1	1.4	1.8	-0.4
Number of incorrect matches in round	1.7	2.9	7.1	-2.6	-2.7	0.6	1.0	-0.0	0.4	2.2
Past tobacco smoking	1.6	3.0	4.8	0.9	1.4	-2.0	-1.8	-2.0	-2.2	-1.6
Alcohol usually taken with meals	0.1	0.2	0.6	-0.8	-0.4	0.4	0.1	0.1	0.7	0.1
Nervous feelings	0.8	1.5	3.2	-0.9	0.1	-1.6	-1.2	-1.8	-1.4	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	-1.3	-0.3	-0.6	-0.1	-0.1	-0.8	-0.1
Hearing difficulty/problems with background noise	0.7	1.1	5.6	0.7	2.4	-0.4	-0.5	0.1	-1.0	-0.7
Hair/balding pattern: Pattern 2	0.6	0.8	1.9	0.7	1.1	0.8	0.8	0.6	0.0	1.4
Had menopause	0.2	0.3	1.4	-1.2	-0.6	0.2	-0.0	-0.2	0.2	0.3
Had other major operations	0.8	1.0	3.8	-1.9	-0.4	-0.6	-0.6	-1.1	-0.9	0.3
Forced vital capacity (FVC)	0.9	3.4	8.0	2.8	1.5	2.1	1.9	1.7	0.9	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.5	0.1	0.4	-0.7	-0.7	-0.9	-1.1	1.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.0	1.3	0.9	-0.5	-0.4	0.3	-0.3	-2.0
Qualifications: None of the above	0.5	1.2	6.2	-2.5	-0.6	-0.5	0.2	-0.8	-0.7	0.3
Financial difficulties in last 2 years	2.1	2.8	7.4	-2.7	-2.7	-1.2	-0.6	-1.8	0.3	-0.1
Mouth/teeth dental problems	0.4	0.7	2.3	1.5	1.1	0.2	-0.2	0.1	-0.4	-0.9
Heart attack	0.4	0.5	2.7	0.3	1.6	0.4	0.8	0.3	-0.0	0.4
Allergy	0.6	1.3	3.2	1.4	-1.0	0.9	0.3	0.3	1.6	1.8
Pain all over the body in last month	1.4	1.5	5.4	-0.6	-2.3	0.8	0.4	0.1	1.2	1.7
Diabetes (self-reported)	1.3	2.0	6.1	-1.9	-2.5	0.6	1.1	0.7	1.5	0.1
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	7.7	-2.8	-2.1	-1.2	-0.9	-1.2	0.2	-2.2
Medication: Ramipril	0.3	0.4	1.7	-1.3	-0.7	-0.4	0.1	-0.1	0.0	0.7
Medication: Simvastatin	0.9	1.3	3.6	0.6	-1.1	0.9	0.5	0.7	1.9	-1.6
Fluid intelligence score	0.9	1.9	3.6	0.3	-1.2	1.6	1.4	1.2	1.9	1.3
Illnesses of siblings	0.3	0.4	0.9	-0.9	-0.4	0.5	0.8	0.3	0.2	0.9
Neuroticism score	0.8	1.6	5.5	-2.3	-2.1	-0.4	-0.4	-0.5	0.3	0.6
Weight	1.3	6.5	12.0	2.3	-2.0	3.0	2.6	2.8	3.5	0.4
Impedance of arm (right)	1.1	5.1	14.4	-0.9	3.8	-2.0	-1.3	-1.4	-3.2	-1.6
Arm fat percentage (right)	0.2	0.7	3.7	0.8	-0.3	-0.5	-0.6	0.2	0.2	-1.9
Trunk fat-free mass	1.9	10.9	19.7	2.8	-2.7	4.1	3.3	3.5	4.4	1.1
Hip circumference	0.7	3.2	5.6	1.7	-1.6	2.0	1.8	1.8	2.4	-0.8
Time employed in main current job	2.5	2.9	5.7	-0.6	1.0	-1.8	-2.4	-2.0	-1.7	-1.6
Alcohol intake versus 10 years previously	0.4	0.5	1.1	-0.4	0.3	0.8	1.0	0.8	0.9	-0.1
Father’s age at death	0.4	0.5	1.9	0.5	1.4	-0.5	-0.7	0.1	-0.7	0.2
Worrier / anxious feelings	0.9	1.6	3.6	-1.6	-1.7	0.8	0.2	0.9	1.0	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	-0.5	-0.3	0.8	1.2	1.0	1.0	1.1
Falls in the last year	1.2	1.7	4.4	-0.8	1.7	-1.4	-0.9	-1.0	-2.1	-0.0
Hair/balding pattern: Pattern 3	0.4	0.5	1.3	-0.6	-0.9	0.6	0.3	0.7	0.6	1.1
Number of live births	2.5	3.6	5.8	-1.4	1.0	-2.3	-2.3	-2.4	-1.6	-1.7
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	8.4	2.9	2.0	1.2	1.0	1.0	0.2	0.7
Pulse rate	2.9	4.8	14.1	-1.3	-3.8	2.0	1.9	1.6	2.5	1.3
Happiness	0.3	0.4	1.5	1.2	0.3	-0.5	-0.2	-0.1	0.1	-0.8
Noisy workplace	1.1	1.3	2.5	-1.0	0.9	-1.6	-1.4	-1.0	-1.2	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.8	1.0	0.4	1.1	0.8	1.0	1.3	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	0.7	1.0	-0.4	-0.0	-0.8	-0.7	-0.1
Mouth/teeth dental problems: Dentures	0.7	1.2	5.7	-2.4	-1.4	-0.3	0.0	-0.6	0.1	-0.1
Asthma	0.4	0.7	2.0	-1.4	-0.8	0.9	0.8	0.7	0.5	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	3.6	1.2	-1.1	1.7	1.9	1.7	1.2	0.8
Medication: Cholesterol lowering	0.2	0.3	0.8	0.5	-0.9	-0.0	-0.4	0.0	0.8	-0.5
Depression (self-reported)	0.7	0.8	2.0	-0.7	-1.4	0.2	0.1	0.7	1.4	0.9
Medication: Lansoprazole	0.9	1.0	2.2	1.0	0.7	1.2	0.7	1.5	1.1	0.3
Prospective memory result	3.8	4.7	7.5	1.2	-1.5	2.6	2.7	2.7	2.3	1.7
Lung cancer (father)	2.0	2.3	9.4	-3.1	-2.3	-0.8	-0.5	-0.9	0.2	-0.1
Illnesses of mother	0.1	0.1	0.6	0.3	-0.4	-0.0	-0.1	-0.0	-0.0	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	5.1	2.3	1.6	1.3	1.2	0.9	-0.1	1.3
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	1.2	-0.7	0.9	0.7	0.9	0.8	0.9
Impedance of arm (left)	0.7	3.4	14.1	-0.7	3.8	-1.2	-0.5	-0.6	-2.5	-0.9
Arm fat mass (right)	0.4	1.5	3.0	1.6	-1.2	0.8	0.6	1.1	1.7	-1.2
Trunk predicted mass	1.9	10.7	19.4	2.7	-2.6	4.1	3.3	3.5	4.4	1.1
Standing height	1.7	17.1	32.6	3.2	-0.9	5.7	5.3	4.7	4.6	2.4
Length of working week for main job	2.5	2.8	4.6	-0.5	0.9	-2.1	-2.1	-1.9	-1.9	-1.6
Exposure to tobacco smoke at home	0.2	0.2	1.3	-0.5	-1.1	0.2	0.2	0.1	0.1	0.2
Breastfed as a baby	0.4	0.5	1.8	0.5	-1.2	0.4	0.1	0.3	1.3	0.1
Tense / ‘highly strung’	0.7	1.2	3.2	-1.8	-1.8	-0.8	-0.5	-0.8	0.5	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	-0.9	-0.3	-0.9	-0.8	-0.2	0.4	-1.1
Hair/balding pattern: Pattern 4	0.7	1.7	4.3	-0.6	-0.0	1.6	2.1	1.5	0.2	1.6
Birth weight of first child	0.1	0.1	0.4	0.6	-0.0	0.4	0.2	0.2	0.2	0.3
Peak expiratory flow (PEF)	2.8	6.6	13.8	3.2	3.7	-1.9	-1.8	-1.6	-2.8	-2.3
Pulse wave reflection index	0.7	0.9	3.2	1.8	1.1	0.4	0.3	0.5	-0.2	1.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.2	0.0	1.7	-0.9	-0.3	-0.2	-1.0	-2.0
Loud music exposure frequency	0.2	0.2	0.9	0.3	-0.9	-0.4	-0.5	-0.3	0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	0.5	-0.2	0.5	0.0	0.7	0.8	0.9
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	-0.2	0.1	-0.3	-0.2	-0.2	0.2	-0.6
Blood clot in the leg (DVT)	1.0	1.3	2.1	0.8	0.2	1.4	1.5	1.2	1.0	1.4
Medication: Paracetamol	1.6	2.6	7.0	-0.9	-2.7	1.4	1.6	1.4	1.2	1.6
Headache pain in last month	0.6	1.0	5.2	-0.0	0.8	-0.6	-0.8	0.3	-0.2	-2.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	-0.5	1.2	-0.9	-0.5	-0.9	-1.0	-0.5
Glaucoma (self-reported)	0.1	0.1	0.3	0.5	0.2	0.1	-0.2	0.3	0.3	-0.5
Gout (self-reported)	1.5	2.1	4.5	-0.8	-2.1	1.4	0.9	1.3	2.0	1.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.0	-0.0	0.2	0.0	-0.0	-0.3	0.3
Medication: Amlodipine	0.5	0.8	2.6	1.6	1.4	-0.1	-0.4	0.6	-0.5	0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.7	0.3	-0.5	0.4	0.1	0.2	0.1	0.8
Birth weight	0.1	0.2	1.0	1.0	0.5	-0.4	-0.4	-0.3	-0.4	-0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.2	0.6	-0.2	0.3	-0.1	-0.1	-0.8
High blood pressure (siblings)	0.6	0.8	2.2	1.5	-0.1	0.9	0.7	0.8	1.3	-0.4
Forced vital capacity (FVC), Best measure	0.9	3.2	5.2	2.3	1.3	2.3	2.0	1.6	0.8	1.8
Body fat percentage	0.1	0.3	1.2	0.7	-0.6	-0.1	-0.0	0.4	0.4	-1.1
Leg fat percentage (right)	0.1	0.3	1.3	0.1	-0.8	-0.4	-0.2	-0.0	0.1	-1.1
Arm fat-free mass (right)	2.5	12.9	23.4	2.6	-3.3	4.4	3.7	3.6	4.8	1.8
Exposure to tobacco smoke outside home	0.7	0.9	2.3	-0.1	-1.2	0.7	1.0	1.2	1.5	-0.1
Comparative body size at age 10	0.1	0.3	1.0	-0.7	-1.0	-0.5	-0.5	-0.4	-0.2	-0.0
Number of full brothers	0.7	0.9	3.0	1.7	1.7	0.2	0.2	0.6	-0.1	-0.3
Worry too long after embarrassment	1.1	1.9	6.5	-2.5	-1.9	-0.7	-1.0	-0.8	0.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.3	-0.9	-0.1	-0.5	0.0	-0.1	-0.1	-1.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.2	0.3	-0.7	-0.2	-0.6	-0.6	-0.3
Number of children fathered	1.2	1.3	2.5	-0.8	-0.3	-1.3	-1.5	-1.6	0.0	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	4.8	-0.4	-1.5	1.3	1.4	0.9	1.2	2.2
Age at first live birth	0.9	1.6	7.5	2.7	1.4	0.4	0.3	0.5	-0.5	0.9
Pulse wave peak to peak time	0.3	0.3	0.8	-0.9	0.4	-0.4	-0.2	-0.4	-0.4	-0.7
Health satisfaction	1.0	1.2	2.1	-1.4	-0.1	-1.4	-1.4	-1.4	-0.3	-0.9
Shortness of breath walking on level ground	0.5	0.6	2.8	0.4	0.8	0.1	0.3	0.4	0.8	-1.7
Qualifications: College or University degree	0.9	2.8	14.1	3.8	1.9	0.8	0.2	0.9	0.5	-0.7
Eye problems/disorders: None of the above	0.2	0.2	0.9	-0.5	-0.2	-0.3	-0.1	-0.9	-0.3	0.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.4	-1.0	-0.5	-1.2	-1.5	-0.9	-0.0	-1.8
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.6	-0.7	-0.1	-0.5	0.3	0.4	0.4
Medication for pain relief, constipation, heartburn	1.2	2.0	8.0	1.4	2.8	-0.8	-0.6	-1.0	-1.0	-1.1
Neck or shoulder pain in last month	0.3	0.4	0.8	-0.5	-0.6	0.6	0.1	0.8	0.9	0.6
Medication: Blood pressure	0.8	1.4	2.2	1.2	-1.4	1.1	0.7	1.4	1.5	0.8
Angina (self-reported)	0.5	0.7	2.2	-1.5	-0.8	0.5	0.6	0.4	1.0	0.3
Migraine (self-reported)	1.0	1.2	2.5	-1.6	-1.2	-1.0	-1.3	-0.9	-0.2	0.9
Medication: Ibuprofen	0.8	0.9	2.1	0.5	-0.7	1.2	1.4	1.1	0.6	0.7
Medication: Allopurinol	1.0	1.3	3.3	-0.2	-1.8	1.0	0.3	1.1	1.8	0.4
Medication: Omeprazole	0.1	0.1	0.2	0.1	-0.3	0.4	0.3	0.2	0.3	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.4	0.6	-0.1	0.1	-0.4	-0.8	0.4
Mean time to correctly identify matches	0.3	0.6	1.3	-1.1	-1.0	0.6	1.1	0.4	0.4	0.4
Heart disease (mother)	0.8	0.9	2.1	-0.3	-0.3	1.4	1.4	0.9	0.8	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	4.5	-0.5	1.2	-2.1	-1.6	-1.7	-2.1	-0.6
Whole body fat mass	0.3	1.4	2.5	1.3	-1.2	1.1	0.9	1.2	1.6	-0.6
Leg fat mass (right)	0.4	1.6	3.3	1.2	-1.6	1.1	1.0	1.2	1.8	-0.7
Arm predicted mass (right)	2.4	12.5	23.6	2.3	-3.4	4.4	3.6	3.5	4.9	1.8
Pulse rate, automated reading	1.8	5.8	16.9	-0.2	-4.1	2.3	2.0	1.9	2.6	2.0
Alcohol intake frequency.	0.3	0.8	1.3	-0.8	1.0	-1.1	-0.5	-1.1	-1.1	0.3
Comparative height size at age 10	1.2	6.6	11.6	2.9	-0.1	3.4	3.2	3.2	2.4	0.5
Number of full sisters	0.7	0.8	4.2	-0.5	1.0	-0.5	-0.4	0.0	-0.3	-2.0
Suffer from ‘nerves’	0.5	0.8	2.7	-1.2	-1.6	0.2	0.0	0.0	1.3	0.0
Overall health rating	0.5	1.1	2.7	-0.6	-0.5	1.1	1.0	1.0	1.2	1.7
Chest pain or discomfort	1.5	2.1	8.2	-2.9	-1.9	-1.1	-0.8	-1.2	-0.0	0.1
Had major operations	1.3	1.6	3.1	1.6	-0.3	1.4	1.4	1.2	1.8	0.2
Age at last live birth	0.9	1.3	4.9	2.2	1.9	0.0	-0.0	0.2	-0.0	-0.8
Family relationship satisfaction	0.7	0.9	2.0	0.4	1.1	-0.8	-0.6	-0.8	-1.1	-1.4
Leg pain on walking	0.3	0.4	1.7	-1.3	-0.3	-0.7	-0.7	-0.1	0.0	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.9	-0.7	1.0	-1.6	-1.0	-1.3	-2.2	-0.3
Commuting to job workplace: Car/motor vehicle	3.2	3.6	7.4	-0.5	-2.7	1.8	2.1	1.6	2.1	1.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	1.1	1.2	0.1	-0.2	0.6	-0.6	0.8
Medication: Aspirin	0.1	0.1	0.7	-0.2	-0.8	0.2	0.1	0.1	0.4	0.3
Supplements: Vitamin C	1.9	2.2	4.6	-1.5	-0.5	-1.5	-1.7	-2.1	-1.4	1.1
Knee pain experienced in last month	0.1	0.2	0.6	-0.6	0.1	0.3	0.3	0.8	0.1	0.4
Hypertension (Self-reported)	0.0	0.1	0.7	0.0	-0.2	-0.1	-0.2	0.0	-0.3	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.8	-0.8	-0.3	-1.0	-0.9	-0.3	-0.7	-1.3
Illnesses of father: Heart disease	0.2	0.2	1.1	0.6	0.3	-0.2	-0.1	-0.4	0.0	-1.0
Illnesses of siblings: Diabetes	0.1	0.1	0.5	0.1	-0.7	0.0	-0.2	0.0	-0.0	0.6
Smoking status: Previous	2.6	3.9	5.5	-0.6	-2.1	2.0	1.8	2.1	2.4	2.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	2.4	0.6	-0.4	1.5	1.4	0.9	0.8	0.4
Whole body fat-free mass	2.0	11.6	21.4	2.9	-2.8	4.2	3.4	3.6	4.6	1.2
Leg fat-free mass (right)	1.8	9.7	18.1	2.8	-2.3	3.8	3.2	3.3	4.3	1.1
Arm fat percentage (left)	0.1	0.6	2.4	0.9	-0.4	-0.1	-0.1	0.6	0.6	-1.5
Average weekly red wine intake	0.1	0.1	0.5	-0.0	0.7	0.3	0.2	0.3	-0.0	-0.0
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.9	0.4	1.7	-1.2	-1.0	-0.8	-1.4	-1.5
Mood swings	1.5	2.7	6.7	-2.5	-2.6	0.4	0.8	0.2	0.5	2.2
Loneliness, isolation	1.6	2.2	10.3	-3.2	-1.9	-0.6	-0.0	-0.6	-0.7	0.7
Long-standing illness, disability or infirmity	0.7	1.0	3.1	-0.4	0.0	1.1	1.8	1.3	1.0	-0.1
Ever had bowel cancer screening	0.1	0.1	0.3	-0.1	-0.2	0.1	-0.2	0.2	-0.6	0.4
Diabetes diagnosed by doctor	0.8	1.3	3.7	-1.5	-1.9	0.5	1.1	0.7	1.3	0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	3.8	-0.5	0.1	-1.9	-1.8	-1.9	-1.4	-1.4
Friendships satisfaction	1.9	2.3	3.8	-0.2	1.3	-1.9	-1.7	-1.4	-1.5	-1.8
Qualifications: nursing, teaching	0.1	0.1	0.3	0.6	0.3	-0.1	-0.3	0.1	0.2	-0.1
Commuting to job workplace: Walk	0.3	0.3	0.7	0.8	0.3	-0.6	-0.8	-0.5	-0.5	-0.0
Eye problems/disorders: Cataract	2.1	2.5	5.1	-0.8	0.4	-1.8	-2.0	-1.6	-1.2	-2.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.7	-1.0	-2.4	0.2	0.5	0.1	1.2	1.0
Medication for cholesterol	0.1	0.2	0.5	-0.4	0.1	-0.4	-0.7	-0.4	-0.0	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.0	-0.6	-2.0	1.5	1.2	1.3	1.6	1.4
Back pain experienced in last month	0.8	1.2	2.2	-1.2	-1.2	0.9	1.5	0.4	1.4	0.6
Mineral and other dietary supplements	0.6	0.8	1.9	1.2	1.4	0.9	0.5	0.9	0.4	0.2
Breast cancer (self-reported)	2.6	3.1	7.5	-1.9	-2.7	-1.5	-2.0	-1.9	0.3	-0.9
Asthma (self-reported)	0.2	0.5	1.8	-1.4	-0.4	0.7	0.6	0.5	0.2	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.5	0.0	0.1	-0.0	-0.0	0.3	-0.2	0.7
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.7	-0.6	-0.1	0.1	0.8	0.2	-0.4
Medication: Aspirin	0.2	0.3	0.8	-0.4	-0.9	0.3	0.2	0.1	0.6	0.6
Medication: Gliclazide	1.3	1.5	3.7	-1.4	-1.9	0.8	1.2	0.9	1.3	-0.0
Illnesses of father: None of the above (group 1)	1.4	1.8	7.1	-2.7	-0.9	-0.6	-0.5	-1.0	-0.5	1.6
Smoking status: Current	0.5	0.8	1.7	-1.3	0.6	-0.8	-0.4	-0.9	-1.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.7	0.2	-0.3	0.9	0.7	0.6	0.8	0.2
Whole body water mass	2.0	11.4	22.0	2.9	-2.8	4.1	3.3	3.5	4.7	1.1
Leg predicted mass (right)	1.8	9.4	17.8	2.7	-2.4	3.7	3.1	3.2	4.2	1.0
Arm fat mass (left)	0.5	1.9	3.8	1.5	-1.3	1.3	1.0	1.5	2.0	-0.7
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	-1.0	-0.8	0.2	0.4	0.6	0.5	0.2
Average weekly champagne plus white wine intake	0.8	1.1	3.8	1.7	0.3	-0.4	-0.8	-0.7	-0.0	-1.9
Miserableness	0.9	1.5	5.1	-2.2	-2.0	-0.5	-0.5	-0.7	0.7	-0.1
Guilty feelings	0.5	0.7	1.6	-0.8	-0.5	-0.9	-1.2	-0.7	-0.9	-0.5
Wears glasses or contact lenses	2.7	3.1	5.7	0.3	-1.6	1.9	1.5	2.1	2.4	1.7
Ever taken oral contraceptive pill	0.7	0.8	1.8	-0.7	-0.3	-1.2	-1.1	-1.3	-0.7	0.1
Hearing aid user	1.0	1.1	2.9	-1.4	-0.2	-0.8	-0.5	-1.2	-1.7	0.9
Mother’s age at death	0.5	0.6	1.9	0.9	0.2	0.9	0.1	1.4	0.5	0.8
Financial situation satisfaction	1.2	1.5	3.5	-1.5	-1.9	-1.2	-1.2	-1.4	-0.2	0.4
Tinnitus: Yes, now most or all of the time	2.0	2.3	4.1	-2.0	-0.4	-1.8	-1.9	-1.9	-1.4	-0.3
Commuting to job workplace: Public transport	1.7	2.0	3.6	1.6	-0.3	1.8	1.7	1.3	1.9	0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	0.6	-0.6	0.3	0.2	0.3	0.8	0.3
Medication: Blood pressure	0.1	0.2	0.5	-0.6	0.3	0.1	0.3	-0.1	-0.2	0.7
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.5	-0.3	0.8	1.3	1.5	1.6	0.7	0.0
Supplements: Fish oil (including cod liver oil)	0.7	1.0	3.3	-1.6	-1.8	-0.5	-0.1	-0.7	-0.1	0.3
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.1	0.3	-0.4	-0.5	-0.1	-0.5	0.4
Medication: Bendroflumethiazide	0.4	0.6	2.5	-1.6	-0.8	-0.1	0.3	-0.3	-0.8	0.2
Medication: Paracetamol	1.6	2.4	7.0	-1.2	-2.6	1.3	1.5	1.2	1.3	1.3
Medication: Lisinopril	0.1	0.2	0.5	-0.4	-0.7	0.2	0.2	0.3	0.5	0.1
Medication: Atorvastatin	1.1	1.4	2.1	0.5	-1.0	1.3	1.4	1.4	1.5	1.0
Illnesses of father: High blood pressure	1.3	1.6	5.4	2.3	-0.2	0.9	0.4	1.3	1.7	-0.6
Alcohol drinker status: Never	0.2	0.2	0.5	0.4	0.3	-0.5	-0.4	-0.3	-0.7	-0.4
Ever smoked	0.8	1.3	2.4	-1.0	-0.0	1.4	1.5	1.6	1.1	0.7
Basal metabolic rate	1.8	10.0	18.7	2.9	-2.5	3.9	3.2	3.4	4.3	0.8
Leg fat percentage (left)	0.1	0.4	1.7	-0.1	-0.8	-0.6	-0.5	-0.2	-0.0	-1.3
Arm fat-free mass (left)	1.7	8.6	17.8	2.4	-2.9	3.5	2.8	2.8	4.2	0.9
Number of operations (self-reported)	0.2	0.2	0.6	0.4	0.6	0.4	0.1	0.5	0.8	-0.4
Average weekly beer plus cider intake	0.4	0.6	0.9	0.9	-1.0	0.6	0.9	0.3	0.7	0.7
Irritability	0.4	0.7	3.1	-0.2	-0.5	-0.5	-0.5	-0.3	-0.9	1.8
Risk taking	1.1	1.6	3.0	-1.7	-0.6	-1.3	-1.3	-1.5	-0.1	-1.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.2	-0.4	-0.2	-0.5	0.1	-0.0	0.4
Fractured/broken bones in last 5 years	1.1	1.5	3.8	-0.0	0.7	-1.4	-1.4	-1.1	-0.8	-2.0
Age started oral contraceptive pill	1.1	1.3	3.8	-0.6	-1.1	1.1	1.4	0.5	0.5	2.0
Diastolic blood pressure, automated reading	0.3	0.9	5.1	2.3	-0.2	0.5	0.3	0.8	0.0	0.0
Ever depressed for a whole week	1.0	1.3	3.6	0.5	1.1	-0.9	-1.2	-0.0	-1.2	-1.9
Unable to work because of sickness or disability	0.8	1.0	1.7	0.7	-0.1	1.2	1.3	1.1	1.0	1.1
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.0	-0.4	0.4	0.4	-0.1	0.1	0.2
Myopia	1.0	1.4	3.6	0.0	-1.9	0.8	1.3	0.6	1.6	1.1
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	-0.5	-0.6	-0.7	-0.6	-1.0	0.1	-0.8
Cholesterol lowering medication	0.9	1.4	2.4	-0.4	-1.0	1.5	1.5	1.5	1.3	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.6	-0.2	-0.8	-0.1	-0.3	-0.1	0.2	-0.4
Pain experienced in last month	0.5	0.8	2.6	0.9	0.4	-0.6	-0.6	-1.1	-1.6	0.6
Supplements: Calcium	0.5	0.5	1.4	1.2	0.0	0.3	0.7	1.0	0.8	-0.2
Basal cell carcinoma (self-reported)	2.3	2.8	5.9	2.4	0.3	2.0	2.0	1.9	1.4	0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	0.2	1.4	0.6	0.9	0.4	0.1	0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.8	0.8	0.1	1.2	1.2	1.0	0.9	1.3
Heart disease (siblings)	1.3	1.5	3.6	-0.4	-1.9	1.3	1.1	1.0	1.7	0.6
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.1	0.3	-0.9	-0.9	-0.6	-0.9	-0.4
Pack years of smoking	0.7	1.0	1.8	-0.2	0.3	-1.3	-0.7	-1.2	-1.2	-1.4
Impedance of whole body	0.8	3.8	11.2	-1.3	3.3	-1.6	-0.7	-1.3	-3.0	-0.6
Leg fat mass (left)	0.4	1.6	3.4	1.0	-1.6	1.1	1.0	1.2	1.8	-0.6
Arm predicted mass (left)	2.0	10.0	19.7	2.6	-3.1	3.8	3.1	3.0	4.4	1.1