TWAS hub - ARHGAP32

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.2280	0.0730	6.2e-04	0.055	NA	0.066	NA	0.073	8.3e-04	NA	2.5e-04	NA	1.2e-04
2	GTEx	Adrenal Gland	0.1893	0.0678	1.3e-03	0.170	NA	0.071	NA	0.145	1.1e-06	NA	1.6e-03	NA	7.0e-06
3	GTEx	Cells Transformed fibroblasts	0.2330	0.0460	3.9e-09	0.161	NA	0.158	NA	0.151	3.9e-12	NA	6.0e-12	NA	2.1e-11
4	GTEx	Heart Atrial Appendage	0.3870	0.0800	1.1e-06	0.183	NA	0.090	NA	0.128	1.2e-08	NA	7.3e-05	NA	2.4e-06
5	GTEx	Nerve Tibial	0.4350	0.0503	0.0e+00	0.394	NA	0.351	NA	0.406	1.3e-29	NA	8.5e-26	NA	1.1e-30
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0422	0.0224	7.6e-04	0.009	0.022	0.016	NA	0.016	2.7e-02	0.0013	5.7e-03	NA	5.8e-03
7	TCGA	Thyroid Carcinoma	0.0580	0.0310	4.9e-03	-0.002	0.015	0.019	NA	0.004	5.6e-01	0.0120	4.9e-03	NA	1.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Prospective memory result	3.8	4.7	7.5	1.2	-1.5	2.6	2.7	2.7	2.3	1.7
Commuting to job workplace: Car/motor vehicle	3.2	3.6	7.4	-0.5	-2.7	1.8	2.1	1.6	2.1	1.8
Pulse rate	2.9	4.8	14.1	-1.3	-3.8	2.0	1.9	1.6	2.5	1.3
Peak expiratory flow (PEF)	2.8	6.6	13.8	3.2	3.7	-1.9	-1.8	-1.6	-2.8	-2.3
Bilateral oophorectomy (both ovaries removed)	2.7	3.2	5.2	0.7	-0.6	2.1	2.3	2.3	2.0	1.7
Wears glasses or contact lenses	2.7	3.1	5.7	0.3	-1.6	1.9	1.5	2.1	2.4	1.7
Smoking status: Previous	2.6	3.9	5.5	-0.6	-2.1	2.0	1.8	2.1	2.4	2.3
Breast cancer (self-reported)	2.6	3.1	7.5	-1.9	-2.7	-1.5	-2.0	-1.9	0.3	-0.9
Hearing difficulty/problems: Yes	2.5	3.8	8.9	-0.1	2.5	-2.0	-2.1	-1.8	-3.0	-0.1
Time employed in main current job	2.5	2.9	5.7	-0.6	1.0	-1.8	-2.4	-2.0	-1.7	-1.6
Number of live births	2.5	3.6	5.8	-1.4	1.0	-2.3	-2.3	-2.4	-1.6	-1.7
Length of working week for main job	2.5	2.8	4.6	-0.5	0.9	-2.1	-2.1	-1.9	-1.9	-1.6
Arm fat-free mass (right)	2.5	12.9	23.4	2.6	-3.3	4.4	3.7	3.6	4.8	1.8
Arm predicted mass (right)	2.4	12.5	23.6	2.3	-3.4	4.4	3.6	3.5	4.9	1.8
Multivitamins +/- minerals	2.3	2.9	6.6	-1.9	-2.6	-1.6	-1.4	-2.1	-0.7	-0.7
Basal cell carcinoma (self-reported)	2.3	2.8	5.9	2.4	0.3	2.0	2.0	1.9	1.4	0.4
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	7.7	-2.8	-2.1	-1.2	-0.9	-1.2	0.2	-2.2
Taking other prescription medications	2.1	3.3	9.8	-3.0	-3.1	0.2	0.4	0.3	0.8	1.8
Hayfever, allergic rhinitis or eczema	2.1	4.5	8.1	-1.4	1.8	-2.5	-1.7	-1.6	-2.9	-2.6
Sitting height	2.1	14.9	25.9	3.9	-0.7	5.1	4.6	4.4	4.7	0.7
Financial difficulties in last 2 years	2.1	2.8	7.4	-2.7	-2.7	-1.2	-0.6	-1.8	0.3	-0.1
Eye problems/disorders: Cataract	2.1	2.5	5.1	-0.8	0.4	-1.8	-2.0	-1.6	-1.2	-2.3
Height	2.0	38.6	69.6	3.6	-2.8	8.3	7.9	7.5	6.6	4.3
Vitamin and mineral supplements	2.0	2.7	5.3	2.0	1.6	1.7	1.6	2.3	1.1	0.1
Lung cancer (father)	2.0	2.3	9.4	-3.1	-2.3	-0.8	-0.5	-0.9	0.2	-0.1
Whole body fat-free mass	2.0	11.6	21.4	2.9	-2.8	4.2	3.4	3.6	4.6	1.2
Whole body water mass	2.0	11.4	22.0	2.9	-2.8	4.1	3.3	3.5	4.7	1.1
Tinnitus: Yes, now most or all of the time	2.0	2.3	4.1	-2.0	-0.4	-1.8	-1.9	-1.9	-1.4	-0.3
Arm predicted mass (left)	2.0	10.0	19.7	2.6	-3.1	3.8	3.1	3.0	4.4	1.1
Medication: Co-codamol	1.9	2.2	4.5	-1.0	-1.4	1.8	1.8	1.2	2.1	0.6
Diabetes (father)	1.9	2.4	4.6	0.4	2.1	-1.6	-1.5	-1.4	-1.8	-1.4
Trunk fat-free mass	1.9	10.9	19.7	2.8	-2.7	4.1	3.3	3.5	4.4	1.1
Trunk predicted mass	1.9	10.7	19.4	2.7	-2.6	4.1	3.3	3.5	4.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	4.5	-0.5	1.2	-2.1	-1.6	-1.7	-2.1	-0.6
Supplements: Vitamin C	1.9	2.2	4.6	-1.5	-0.5	-1.5	-1.7	-2.1	-1.4	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	3.8	-0.5	0.1	-1.9	-1.8	-1.9	-1.4	-1.4
Friendships satisfaction	1.9	2.3	3.8	-0.2	1.3	-1.9	-1.7	-1.4	-1.5	-1.8
Body Mass Index (BMI) (2010)	1.8	2.4	5.8	-2.4	-0.9	-1.7	-1.4	-1.9	-1.2	0.3
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.3	0.1	-0.4	1.8	1.6	1.9	2.1	1.4
Leg fat-free mass (left)	1.8	9.6	17.5	3.1	-2.1	3.7	3.1	3.3	4.2	0.9
Leg predicted mass (left)	1.8	9.4	17.2	3.0	-2.1	3.7	3.1	3.3	4.1	0.9
Pulse rate, automated reading	1.8	5.8	16.9	-0.2	-4.1	2.3	2.0	1.9	2.6	2.0
Leg fat-free mass (right)	1.8	9.7	18.1	2.8	-2.3	3.8	3.2	3.3	4.3	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.0	-0.6	-2.0	1.5	1.2	1.3	1.6	1.4
Leg predicted mass (right)	1.8	9.4	17.8	2.7	-2.4	3.7	3.1	3.2	4.2	1.0
Basal metabolic rate	1.8	10.0	18.7	2.9	-2.5	3.9	3.2	3.4	4.3	0.8
Allergy or Eczema	1.7	4.4	9.0	-1.7	2.0	-2.3	-1.6	-1.0	-3.0	-2.4
Maternal smoking around birth	1.7	2.5	5.6	-2.4	-0.9	-1.6	-1.6	-2.1	-1.3	0.1
Number of incorrect matches in round	1.7	2.9	7.1	-2.6	-2.7	0.6	1.0	-0.0	0.4	2.2
Standing height	1.7	17.1	32.6	3.2	-0.9	5.7	5.3	4.7	4.6	2.4
Commuting to job workplace: Public transport	1.7	2.0	3.6	1.6	-0.3	1.8	1.7	1.3	1.9	0.6
Arm fat-free mass (left)	1.7	8.6	17.8	2.4	-2.9	3.5	2.8	2.8	4.2	0.9
Rheumatoid Arthritis	1.6	2.2	3.4	0.6	-1.6	1.7	1.8	1.6	1.6	0.9
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.1	-0.2	-0.8	1.5	2.0	1.8	1.4	-0.3
Age when periods started (menarche)	1.6	3.8	7.3	1.1	2.7	-2.2	-1.8	-1.6	-1.8	-2.0
Supplements: Glucosamine	1.6	2.1	3.5	-1.7	-0.9	-1.7	-1.7	-1.9	-0.9	-0.7
Past tobacco smoking	1.6	3.0	4.8	0.9	1.4	-2.0	-1.8	-2.0	-2.2	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	3.6	1.2	-1.1	1.7	1.9	1.7	1.2	0.8
Medication: Paracetamol	1.6	2.6	7.0	-0.9	-2.7	1.4	1.6	1.4	1.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	4.8	-0.4	-1.5	1.3	1.4	0.9	1.2	2.2
Loneliness, isolation	1.6	2.2	10.3	-3.2	-1.9	-0.6	-0.0	-0.6	-0.7	0.7
Medication: Paracetamol	1.6	2.4	7.0	-1.2	-2.6	1.3	1.5	1.2	1.3	1.3
HbA1C	1.5	1.6	2.3	-0.8	0.9	-1.5	-1.4	-1.5	-1.4	-1.2
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.5	-1.0	-1.9	1.4	1.8	1.5	1.4	0.8
Gout (self-reported)	1.5	2.1	4.5	-0.8	-2.1	1.4	0.9	1.3	2.0	1.1
Chest pain or discomfort	1.5	2.1	8.2	-2.9	-1.9	-1.1	-0.8	-1.2	-0.0	0.1
Mood swings	1.5	2.7	6.7	-2.5	-2.6	0.4	0.8	0.2	0.5	2.2
Stomach or abdominal pain in last month	1.4	1.8	3.3	-1.1	0.6	-1.5	-1.6	-1.1	-1.1	-1.8
Pain all over the body in last month	1.4	1.5	5.4	-0.6	-2.3	0.8	0.4	0.1	1.2	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.9	-0.7	1.0	-1.6	-1.0	-1.3	-2.2	-0.3
Illnesses of father: None of the above (group 1)	1.4	1.8	7.1	-2.7	-0.9	-0.6	-0.5	-1.0	-0.5	1.6
Diabetes (self-reported)	1.3	2.0	6.1	-1.9	-2.5	0.6	1.1	0.7	1.5	0.1
Weight	1.3	6.5	12.0	2.3	-2.0	3.0	2.6	2.8	3.5	0.4
Had major operations	1.3	1.6	3.1	1.6	-0.3	1.4	1.4	1.2	1.8	0.2
Medication: Gliclazide	1.3	1.5	3.7	-1.4	-1.9	0.8	1.2	0.9	1.3	-0.0
Illnesses of father: High blood pressure	1.3	1.6	5.4	2.3	-0.2	0.9	0.4	1.3	1.7	-0.6
Heart disease (siblings)	1.3	1.5	3.6	-0.4	-1.9	1.3	1.1	1.0	1.7	0.6
Depressed Affect (Nagel 2018)	1.2	2.5	7.6	-2.8	-2.4	0.4	0.8	0.1	0.7	1.7
Triglycerides	1.2	2.0	5.7	-2.4	-1.0	-1.0	-0.9	-1.9	-1.4	0.4
Blood Platelet Count	1.2	14.4	31.2	1.1	5.2	-3.9	-3.1	-3.0	-5.6	-2.9
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.3	-1.1	0.2	-1.5	-1.3	-1.1	-1.5	-0.6
Falls in the last year	1.2	1.7	4.4	-0.8	1.7	-1.4	-0.9	-1.0	-2.1	-0.0
Number of children fathered	1.2	1.3	2.5	-0.8	-0.3	-1.3	-1.5	-1.6	0.0	-1.4
Medication for pain relief, constipation, heartburn	1.2	2.0	8.0	1.4	2.8	-0.8	-0.6	-1.0	-1.0	-1.1
Comparative height size at age 10	1.2	6.6	11.6	2.9	-0.1	3.4	3.2	3.2	2.4	0.5
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.9	0.4	1.7	-1.2	-1.0	-0.8	-1.4	-1.5
Financial situation satisfaction	1.2	1.5	3.5	-1.5	-1.9	-1.2	-1.2	-1.4	-0.2	0.4
Number of treatments/medications taken	1.1	2.0	9.9	-1.6	-3.1	0.3	0.1	0.5	1.1	0.3
Impedance of arm (right)	1.1	5.1	14.4	-0.9	3.8	-2.0	-1.3	-1.4	-3.2	-1.6
Noisy workplace	1.1	1.3	2.5	-1.0	0.9	-1.6	-1.4	-1.0	-1.2	-0.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.2	0.0	1.7	-0.9	-0.3	-0.2	-1.0	-2.0
Worry too long after embarrassment	1.1	1.9	6.5	-2.5	-1.9	-0.7	-1.0	-0.8	0.4	-0.7
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.4	-1.0	-0.5	-1.2	-1.5	-0.9	-0.0	-1.8
Medication: Atorvastatin	1.1	1.4	2.1	0.5	-1.0	1.3	1.4	1.4	1.5	1.0
Risk taking	1.1	1.6	3.0	-1.7	-0.6	-1.3	-1.3	-1.5	-0.1	-1.5
Fractured/broken bones in last 5 years	1.1	1.5	3.8	-0.0	0.7	-1.4	-1.4	-1.1	-0.8	-2.0
Age started oral contraceptive pill	1.1	1.3	3.8	-0.6	-1.1	1.1	1.4	0.5	0.5	2.0
HDL Cholesterol	1.0	1.7	5.2	2.3	-0.5	1.0	0.9	1.4	1.7	-0.6
Respiratory disease	1.0	2.2	3.5	-0.4	-1.7	1.9	1.6	1.4	1.9	0.8
Type 2 Diabetes (T2D) (2018)	1.0	1.8	3.7	-0.6	-1.9	1.1	1.5	1.1	1.6	1.1
Sensitivity / hurt feelings	1.0	1.7	5.1	-2.3	-2.1	0.7	0.7	0.4	1.1	0.2
Average weekly fortified wine intake	1.0	1.2	2.4	-0.9	-1.6	-1.0	-1.1	-1.1	-0.6	1.2
Blood clot in the leg (DVT)	1.0	1.3	2.1	0.8	0.2	1.4	1.5	1.2	1.0	1.4
Health satisfaction	1.0	1.2	2.1	-1.4	-0.1	-1.4	-1.4	-1.4	-0.3	-0.9
Migraine (self-reported)	1.0	1.2	2.5	-1.6	-1.2	-1.0	-1.3	-0.9	-0.2	0.9
Medication: Allopurinol	1.0	1.3	3.3	-0.2	-1.8	1.0	0.3	1.1	1.8	0.4
Hearing aid user	1.0	1.1	2.9	-1.4	-0.2	-0.8	-0.5	-1.2	-1.7	0.9
Ever depressed for a whole week	1.0	1.3	3.6	0.5	1.1	-0.9	-1.2	-0.0	-1.2	-1.9
Myopia	1.0	1.4	3.6	0.0	-1.9	0.8	1.3	0.6	1.6	1.1
Neuroticism (Nagel 2018)	0.9	2.1	6.2	-2.5	-2.5	0.4	0.5	0.4	1.0	1.1
Prostate Cancer	0.9	1.3	2.5	1.0	0.1	1.3	1.1	1.5	1.6	-0.5
Primary Biliary Cirrhosis	0.9	1.3	2.5	-1.0	-0.9	1.6	1.4	1.1	1.1	0.3
Chronotype (morning person)	0.9	2.1	7.1	1.9	2.7	0.6	1.0	1.0	-0.4	-1.2
Average weekly spirits intake	0.9	1.1	2.6	0.5	-1.6	0.9	0.3	1.1	1.6	0.4
Diabetes (mother)	0.9	1.1	1.8	-0.9	0.3	-1.1	-0.9	-1.2	-1.3	1.4
Chronic bronchitis/emphysema (father)	0.9	1.1	3.7	1.9	1.5	0.0	-0.2	0.5	-0.8	-0.8
Forced vital capacity (FVC)	0.9	3.4	8.0	2.8	1.5	2.1	1.9	1.7	0.9	1.4
Medication: Simvastatin	0.9	1.3	3.6	0.6	-1.1	0.9	0.5	0.7	1.9	-1.6
Fluid intelligence score	0.9	1.9	3.6	0.3	-1.2	1.6	1.4	1.2	1.9	1.3
Worrier / anxious feelings	0.9	1.6	3.6	-1.6	-1.7	0.8	0.2	0.9	1.0	1.9
Medication: Lansoprazole	0.9	1.0	2.2	1.0	0.7	1.2	0.7	1.5	1.1	0.3
Forced vital capacity (FVC), Best measure	0.9	3.2	5.2	2.3	1.3	2.3	2.0	1.6	0.8	1.8
Age at first live birth	0.9	1.6	7.5	2.7	1.4	0.4	0.3	0.5	-0.5	0.9
Qualifications: College or University degree	0.9	2.8	14.1	3.8	1.9	0.8	0.2	0.9	0.5	-0.7
Age at last live birth	0.9	1.3	4.9	2.2	1.9	0.0	-0.0	0.2	-0.0	-0.8
Miserableness	0.9	1.5	5.1	-2.2	-2.0	-0.5	-0.5	-0.7	0.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.5	-0.3	0.8	1.3	1.5	1.6	0.7	0.0
Cholesterol lowering medication	0.9	1.4	2.4	-0.4	-1.0	1.5	1.5	1.5	1.3	0.2
Schizophrenia vs Biploar Disorder	0.8	1.1	3.0	0.6	-0.9	0.5	0.8	0.6	1.7	-1.5
Major Depression (MDD)	0.8	1.0	2.5	0.8	-1.1	0.8	0.4	1.0	1.6	-1.0
LDL Cholesterol	0.8	1.3	2.2	-1.0	-0.7	-1.1	-1.4	-1.2	-0.7	-1.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.7	-1.6	-0.7	-0.1	-0.7	-0.1	0.6	1.5
Systolic Blood Pressure	0.8	4.0	6.6	0.9	2.6	-2.1	-2.2	-1.8	-2.5	-1.4
Ever had hysterectomy (womb removed)	0.8	1.0	1.9	-0.3	-0.5	1.4	1.3	1.1	0.6	1.0
Medication: Metformin	0.8	1.1	4.4	-0.1	-2.1	0.5	0.6	0.6	1.6	0.2
Impedance of leg (left)	0.8	3.7	8.3	-1.8	2.4	-2.0	-1.2	-1.7	-2.9	-0.7
Nervous feelings	0.8	1.5	3.2	-0.9	0.1	-1.6	-1.2	-1.8	-1.4	-0.9
Had other major operations	0.8	1.0	3.8	-1.9	-0.4	-0.6	-0.6	-1.1	-0.9	0.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.0	1.3	0.9	-0.5	-0.4	0.3	-0.3	-2.0
Neuroticism score	0.8	1.6	5.5	-2.3	-2.1	-0.4	-0.4	-0.5	0.3	0.6
Medication: Blood pressure	0.8	1.4	2.2	1.2	-1.4	1.1	0.7	1.4	1.5	0.8
Medication: Ibuprofen	0.8	0.9	2.1	0.5	-0.7	1.2	1.4	1.1	0.6	0.7
Heart disease (mother)	0.8	0.9	2.1	-0.3	-0.3	1.4	1.4	0.9	0.8	0.9
Diabetes diagnosed by doctor	0.8	1.3	3.7	-1.5	-1.9	0.5	1.1	0.7	1.3	0.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.7	-1.0	-2.4	0.2	0.5	0.1	1.2	1.0
Back pain experienced in last month	0.8	1.2	2.2	-1.2	-1.2	0.9	1.5	0.4	1.4	0.6
Average weekly champagne plus white wine intake	0.8	1.1	3.8	1.7	0.3	-0.4	-0.8	-0.7	-0.0	-1.9
Ever smoked	0.8	1.3	2.4	-1.0	-0.0	1.4	1.5	1.6	1.1	0.7
Unable to work because of sickness or disability	0.8	1.0	1.7	0.7	-0.1	1.2	1.3	1.1	1.0	1.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.8	0.8	0.1	1.2	1.2	1.0	0.9	1.3
Impedance of whole body	0.8	3.8	11.2	-1.3	3.3	-1.6	-0.7	-1.3	-3.0	-0.6
Depression (Nagel 2018)	0.7	1.1	2.2	-0.3	-1.2	0.9	1.2	1.5	1.3	0.0
Fasting Glucose	0.7	0.9	3.6	-0.1	1.9	-0.5	-1.0	0.1	-1.1	-0.3
Impedance of leg (right)	0.7	3.2	7.6	-1.6	2.4	-1.7	-1.0	-1.5	-2.8	-0.5
Hearing difficulty/problems with background noise	0.7	1.1	5.6	0.7	2.4	-0.4	-0.5	0.1	-1.0	-0.7
Hip circumference	0.7	3.2	5.6	1.7	-1.6	2.0	1.8	1.8	2.4	-0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	8.4	2.9	2.0	1.2	1.0	1.0	0.2	0.7
Mouth/teeth dental problems: Dentures	0.7	1.2	5.7	-2.4	-1.4	-0.3	0.0	-0.6	0.1	-0.1
Depression (self-reported)	0.7	0.8	2.0	-0.7	-1.4	0.2	0.1	0.7	1.4	0.9
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	1.2	-0.7	0.9	0.7	0.9	0.8	0.9
Impedance of arm (left)	0.7	3.4	14.1	-0.7	3.8	-1.2	-0.5	-0.6	-2.5	-0.9
Tense / ‘highly strung’	0.7	1.2	3.2	-1.8	-1.8	-0.8	-0.5	-0.8	0.5	0.3
Hair/balding pattern: Pattern 4	0.7	1.7	4.3	-0.6	-0.0	1.6	2.1	1.5	0.2	1.6
Pulse wave reflection index	0.7	0.9	3.2	1.8	1.1	0.4	0.3	0.5	-0.2	1.2
Exposure to tobacco smoke outside home	0.7	0.9	2.3	-0.1	-1.2	0.7	1.0	1.2	1.5	-0.1
Number of full brothers	0.7	0.9	3.0	1.7	1.7	0.2	0.2	0.6	-0.1	-0.3
Number of full sisters	0.7	0.8	4.2	-0.5	1.0	-0.5	-0.4	0.0	-0.3	-2.0
Family relationship satisfaction	0.7	0.9	2.0	0.4	1.1	-0.8	-0.6	-0.8	-1.1	-1.4
Long-standing illness, disability or infirmity	0.7	1.0	3.1	-0.4	0.0	1.1	1.8	1.3	1.0	-0.1
Ever taken oral contraceptive pill	0.7	0.8	1.8	-0.7	-0.3	-1.2	-1.1	-1.3	-0.7	0.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	3.3	-1.6	-1.8	-0.5	-0.1	-0.7	-0.1	0.3
Pack years of smoking	0.7	1.0	1.8	-0.2	0.3	-1.3	-0.7	-1.2	-1.2	-1.4
Alzheimer’s Disease (in mother)	0.6	0.7	2.5	-0.7	-1.6	-0.5	-0.1	-0.4	0.7	-0.9
Heel T-Score	0.6	4.4	8.9	-0.7	-0.1	-2.7	-3.0	-2.9	-2.4	-0.6
Neuroticism	0.6	1.5	4.7	-2.2	-1.9	-0.8	-1.0	-0.7	-0.2	0.3
Angina	0.6	0.8	2.8	-1.7	-0.8	0.5	0.5	0.4	1.0	0.3
Supplements: Zinc	0.6	0.6	1.0	-0.2	-1.0	-0.9	-1.0	-1.0	-0.5	0.5
Severe depression (siblings)	0.6	0.7	3.7	-0.4	0.1	-0.5	-0.9	-0.2	-0.3	-1.9
Pack years adult smoking proportion	0.6	0.9	1.6	-0.1	0.3	-1.3	-0.7	-1.2	-1.1	-1.2
Fed-up feelings	0.6	1.0	2.8	-1.6	-1.7	0.4	0.6	0.6	0.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.4	0.4	1.9	0.2	-0.2	-0.3	-1.1	0.4
Hair/balding pattern: Pattern 2	0.6	0.8	1.9	0.7	1.1	0.8	0.8	0.6	0.0	1.4
Allergy	0.6	1.3	3.2	1.4	-1.0	0.9	0.3	0.3	1.6	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	5.1	2.3	1.6	1.3	1.2	0.9	-0.1	1.3
Headache pain in last month	0.6	1.0	5.2	-0.0	0.8	-0.6	-0.8	0.3	-0.2	-2.3
High blood pressure (siblings)	0.6	0.8	2.2	1.5	-0.1	0.9	0.7	0.8	1.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.8	-0.8	-0.3	-1.0	-0.9	-0.3	-0.7	-1.3
Mineral and other dietary supplements	0.6	0.8	1.9	1.2	1.4	0.9	0.5	0.9	0.4	0.2
Bipolar Disorder or Schizophrenia	0.5	1.2	4.6	-1.1	-2.2	-0.5	-0.1	-1.2	0.9	-0.5
Worry (Nagel 2018)	0.5	1.1	3.4	-1.7	-1.8	0.1	-0.1	-0.0	0.7	0.8
Alzheimer’s Disease (in father)	0.5	0.5	2.4	0.2	1.5	-0.2	0.0	0.0	-0.4	-1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.8	1.5	-1.2	1.1	0.6	0.9	1.7	0.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.3	-1.5	-0.0	-0.3	0.0	-0.8	-1.2	0.0
Systolic blood pressure, automated reading	0.5	1.5	2.3	1.2	1.2	-1.3	-1.5	-0.8	-1.5	-0.8
Townsend deprivation index at recruitment	0.5	0.7	3.0	-1.7	-0.1	-0.2	0.4	-0.7	-0.7	0.7
Current tobacco smoking	0.5	0.8	2.6	-1.6	0.1	-0.8	-0.3	-1.0	-1.2	0.3
Waist circumference	0.5	1.9	3.3	1.6	-1.4	1.3	1.1	1.4	1.8	-0.4
Qualifications: None of the above	0.5	1.2	6.2	-2.5	-0.6	-0.5	0.2	-0.8	-0.7	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	-0.5	-0.3	0.8	1.2	1.0	1.0	1.1
Medication: Amlodipine	0.5	0.8	2.6	1.6	1.4	-0.1	-0.4	0.6	-0.5	0.0
Shortness of breath walking on level ground	0.5	0.6	2.8	0.4	0.8	0.1	0.3	0.4	0.8	-1.7
Angina (self-reported)	0.5	0.7	2.2	-1.5	-0.8	0.5	0.6	0.4	1.0	0.3
Suffer from ‘nerves’	0.5	0.8	2.7	-1.2	-1.6	0.2	0.0	0.0	1.3	0.0
Overall health rating	0.5	1.1	2.7	-0.6	-0.5	1.1	1.0	1.0	1.2	1.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	1.1	1.2	0.1	-0.2	0.6	-0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	2.4	0.6	-0.4	1.5	1.4	0.9	0.8	0.4
Smoking status: Current	0.5	0.8	1.7	-1.3	0.6	-0.8	-0.4	-0.9	-1.3	-0.3
Arm fat mass (left)	0.5	1.9	3.8	1.5	-1.3	1.3	1.0	1.5	2.0	-0.7
Guilty feelings	0.5	0.7	1.6	-0.8	-0.5	-0.9	-1.2	-0.7	-0.9	-0.5
Mother’s age at death	0.5	0.6	1.9	0.9	0.2	0.9	0.1	1.4	0.5	0.8
Pain experienced in last month	0.5	0.8	2.6	0.9	0.4	-0.6	-0.6	-1.1	-1.6	0.6
Supplements: Calcium	0.5	0.5	1.4	1.2	0.0	0.3	0.7	1.0	0.8	-0.2
Bipolar Disorder (2018)	0.4	0.7	1.9	-1.4	-1.4	-0.1	0.0	-0.8	0.2	0.6
Schizophrenia (2018)	0.4	0.8	2.8	-0.2	-1.7	-0.6	-0.1	-1.0	1.0	-0.8
Schizophrenia (2014)	0.4	0.9	1.9	-1.2	-1.4	-0.7	-0.4	-1.3	0.7	-0.4
Ulcerative Colitis	0.4	0.5	1.9	0.1	-0.9	-0.5	-0.0	-0.4	0.8	-1.4
Blood White Count	0.4	3.1	10.7	-3.3	-3.0	-0.6	-0.7	-1.1	0.2	-0.8
Smoking Status	0.4	0.9	2.0	-1.1	-0.3	0.9	1.1	0.8	0.4	1.4
Lung FVC	0.4	1.8	3.5	-0.8	0.9	-1.4	-1.0	-1.2	-1.9	1.8
Relative age of first facial hair	0.4	0.8	2.0	-0.8	0.4	-1.0	-1.4	-0.9	-0.5	-0.8
High blood pressure (mother)	0.4	0.6	1.6	0.1	1.3	-0.6	-0.8	-0.7	-0.7	-0.6
Trunk fat mass	0.4	1.9	2.9	1.6	-1.1	1.4	1.2	1.6	1.7	-0.6
Mouth/teeth dental problems	0.4	0.7	2.3	1.5	1.1	0.2	-0.2	0.1	-0.4	-0.9
Heart attack	0.4	0.5	2.7	0.3	1.6	0.4	0.8	0.3	-0.0	0.4
Alcohol intake versus 10 years previously	0.4	0.5	1.1	-0.4	0.3	0.8	1.0	0.8	0.9	-0.1
Father’s age at death	0.4	0.5	1.9	0.5	1.4	-0.5	-0.7	0.1	-0.7	0.2
Hair/balding pattern: Pattern 3	0.4	0.5	1.3	-0.6	-0.9	0.6	0.3	0.7	0.6	1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.8	1.0	0.4	1.1	0.8	1.0	1.3	-0.0
Asthma	0.4	0.7	2.0	-1.4	-0.8	0.9	0.8	0.7	0.5	-0.3
Arm fat mass (right)	0.4	1.5	3.0	1.6	-1.2	0.8	0.6	1.1	1.7	-1.2
Breastfed as a baby	0.4	0.5	1.8	0.5	-1.2	0.4	0.1	0.3	1.3	0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	-0.5	1.2	-0.9	-0.5	-0.9	-1.0	-0.5
Leg fat mass (right)	0.4	1.6	3.3	1.2	-1.6	1.1	1.0	1.2	1.8	-0.7
Medication: Bendroflumethiazide	0.4	0.6	2.5	-1.6	-0.8	-0.1	0.3	-0.3	-0.8	0.2
Average weekly beer plus cider intake	0.4	0.6	0.9	0.9	-1.0	0.6	0.9	0.3	0.7	0.7
Irritability	0.4	0.7	3.1	-0.2	-0.5	-0.5	-0.5	-0.3	-0.9	1.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	0.2	1.4	0.6	0.9	0.4	0.1	0.4
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.1	0.3	-0.9	-0.9	-0.6	-0.9	-0.4
Leg fat mass (left)	0.4	1.6	3.4	1.0	-1.6	1.1	1.0	1.2	1.8	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	1.6	-0.4	-0.3	-0.7	-0.3	-0.7	-0.1	-1.3
Bipolar Disorder (2011)	0.3	0.3	1.3	-1.2	-0.7	0.1	0.3	0.0	-0.3	0.2
Crohns Disease (2012)	0.3	0.4	1.3	-1.2	-1.0	-0.1	0.0	0.1	0.7	-0.4
Lupus	0.3	0.5	2.5	0.9	-0.2	-0.0	-0.1	-0.5	0.2	-1.6
Blood Eosinophil Count	0.3	2.0	4.8	-2.2	1.2	-1.3	-1.0	-1.3	-1.6	-0.5
Lung FEV1/FVC ratio	0.3	1.5	2.2	0.8	1.2	-1.5	-1.5	-1.2	-1.1	-1.3
Hair Pigment	0.3	9.2	14.9	2.2	1.1	3.9	3.7	3.8	3.7	1.2
Hand grip strength (right)	0.3	0.9	5.2	0.3	-0.2	0.9	0.6	0.1	-0.0	2.3
Relative age voice broke	0.3	0.4	1.2	-0.1	-0.2	1.1	0.5	0.7	0.9	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.9	0.4	1.0	-0.8	-0.7	-0.7	-1.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	-1.3	-0.3	-0.6	-0.1	-0.1	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.5	0.1	0.4	-0.7	-0.7	-0.9	-1.1	1.6
Medication: Ramipril	0.3	0.4	1.7	-1.3	-0.7	-0.4	0.1	-0.1	0.0	0.7
Illnesses of siblings	0.3	0.4	0.9	-0.9	-0.4	0.5	0.8	0.3	0.2	0.9
Happiness	0.3	0.4	1.5	1.2	0.3	-0.5	-0.2	-0.1	0.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	0.7	1.0	-0.4	-0.0	-0.8	-0.7	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	-0.9	-0.3	-0.9	-0.8	-0.2	0.4	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.3	-0.9	-0.1	-0.5	0.0	-0.1	-0.1	-1.1
Pulse wave peak to peak time	0.3	0.3	0.8	-0.9	0.4	-0.4	-0.2	-0.4	-0.4	-0.7
Neck or shoulder pain in last month	0.3	0.4	0.8	-0.5	-0.6	0.6	0.1	0.8	0.9	0.6
Mean time to correctly identify matches	0.3	0.6	1.3	-1.1	-1.0	0.6	1.1	0.4	0.4	0.4
Whole body fat mass	0.3	1.4	2.5	1.3	-1.2	1.1	0.9	1.2	1.6	-0.6
Alcohol intake frequency.	0.3	0.8	1.3	-0.8	1.0	-1.1	-0.5	-1.1	-1.1	0.3
Leg pain on walking	0.3	0.4	1.7	-1.3	-0.3	-0.7	-0.7	-0.1	0.0	0.4
Commuting to job workplace: Walk	0.3	0.3	0.7	0.8	0.3	-0.6	-0.8	-0.5	-0.5	-0.0
Diastolic blood pressure, automated reading	0.3	0.9	5.1	2.3	-0.2	0.5	0.3	0.8	0.0	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.0	0.1	-1.4	0.5	0.2	0.2	0.9	0.2
Ulcerative Colitis (UC)	0.2	0.4	1.5	0.7	-0.3	0.6	0.5	0.5	1.2	0.0
Reaction Time	0.2	0.4	1.0	-0.9	-0.4	0.6	1.0	0.4	0.7	-0.3
Breast Cancer	0.2	0.4	0.9	0.7	-0.9	0.4	0.7	0.2	0.7	-0.8
Age at First Birth	0.2	0.3	1.8	-1.3	-0.0	-0.2	0.0	0.0	0.0	0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.3	-0.6	0.5	-0.4	-0.3	-0.5	0.4	-0.3
BMI	0.2	1.2	2.4	1.6	-1.4	0.8	0.2	1.0	1.5	-0.3
Hand grip strength (left)	0.2	0.4	1.6	0.8	0.4	0.4	0.3	0.3	0.0	1.3
Medication for hormone replacement therapy	0.2	0.2	0.8	0.7	-0.4	-0.0	0.5	0.0	0.1	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.7	-0.3	0.4	-0.6	0.1	0.0	-0.8	-0.6
Qualifications: CSEs or equivalent	0.2	0.2	0.9	0.6	1.0	-0.5	-0.1	0.0	-0.0	-0.2
Medication: Levothyroxine sodium	0.2	0.4	0.6	0.8	0.6	-0.4	-0.8	-0.3	-0.6	-0.5
Body mass index (BMI)	0.2	1.0	2.2	1.0	-1.5	0.5	0.2	0.8	1.4	-0.9
Had menopause	0.2	0.3	1.4	-1.2	-0.6	0.2	-0.0	-0.2	0.2	0.3
Arm fat percentage (right)	0.2	0.7	3.7	0.8	-0.3	-0.5	-0.6	0.2	0.2	-1.9
Medication: Cholesterol lowering	0.2	0.3	0.8	0.5	-0.9	-0.0	-0.4	0.0	0.8	-0.5
Exposure to tobacco smoke at home	0.2	0.2	1.3	-0.5	-1.1	0.2	0.2	0.1	0.1	0.2
Loud music exposure frequency	0.2	0.2	0.9	0.3	-0.9	-0.4	-0.5	-0.3	0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	0.5	-0.2	0.5	0.0	0.7	0.8	0.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.2	0.6	-0.2	0.3	-0.1	-0.1	-0.8
Eye problems/disorders: None of the above	0.2	0.2	0.9	-0.5	-0.2	-0.3	-0.1	-0.9	-0.3	0.6
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.6	-0.7	-0.1	-0.5	0.3	0.4	0.4
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.4	0.6	-0.1	0.1	-0.4	-0.8	0.4
Illnesses of father: Heart disease	0.2	0.2	1.1	0.6	0.3	-0.2	-0.1	-0.4	0.0	-1.0
Asthma (self-reported)	0.2	0.5	1.8	-1.4	-0.4	0.7	0.6	0.5	0.2	-0.4
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.7	-0.6	-0.1	0.1	0.8	0.2	-0.4
Medication: Aspirin	0.2	0.3	0.8	-0.4	-0.9	0.3	0.2	0.1	0.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.7	0.2	-0.3	0.9	0.7	0.6	0.8	0.2
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	-1.0	-0.8	0.2	0.4	0.6	0.5	0.2
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	0.6	-0.6	0.3	0.2	0.3	0.8	0.3
Alcohol drinker status: Never	0.2	0.2	0.5	0.4	0.3	-0.5	-0.4	-0.3	-0.7	-0.4
Number of operations (self-reported)	0.2	0.2	0.6	0.4	0.6	0.4	0.1	0.5	0.8	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	-0.5	-0.6	-0.7	-0.6	-1.0	0.1	-0.8
Crohns Disease (2017)	0.1	0.3	1.1	-1.1	-0.6	-0.1	-0.2	-0.5	0.0	0.2
Ovarian Cancer	0.1	0.1	0.4	0.2	0.0	-0.6	-0.2	-0.4	-0.3	0.5
Mean Putamen Volume	0.1	0.1	0.3	0.1	0.4	0.1	-0.2	0.6	0.2	-0.2
Neuroticism (2016)	0.1	0.2	0.5	-0.7	-0.7	-0.3	-0.0	-0.1	-0.4	0.0
Waist Hip Ratio (WHR)	0.1	0.6	1.6	0.4	0.5	-1.0	-0.4	-0.9	-1.2	0.4
Cardiovascular Disease	0.1	0.4	1.9	0.3	0.4	0.0	-0.3	0.2	-0.6	1.4
Tanning	0.1	1.3	3.5	-1.2	1.9	-0.6	-0.4	-0.6	-1.7	0.3
Trunk fat percentage	0.1	0.4	0.9	0.9	-0.3	0.2	0.3	0.7	0.5	-1.0
Serious illness, injury or assault to yourself	0.1	0.1	0.3	-0.4	-0.5	-0.1	0.2	0.2	-0.1	0.3
High blood pressure	0.1	0.1	0.6	0.3	0.2	0.1	0.0	0.3	-0.5	0.8
Medication: Atenolol	0.1	0.2	0.5	-0.2	0.7	-0.2	0.2	-0.3	-0.5	-0.5
Alcohol usually taken with meals	0.1	0.2	0.6	-0.8	-0.4	0.4	0.1	0.1	0.7	0.1
Illnesses of mother	0.1	0.1	0.6	0.3	-0.4	-0.0	-0.1	-0.0	-0.0	-0.8
Birth weight of first child	0.1	0.1	0.4	0.6	-0.0	0.4	0.2	0.2	0.2	0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	-0.2	0.1	-0.3	-0.2	-0.2	0.2	-0.6
Glaucoma (self-reported)	0.1	0.1	0.3	0.5	0.2	0.1	-0.2	0.3	0.3	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.7	0.3	-0.5	0.4	0.1	0.2	0.1	0.8
Birth weight	0.1	0.2	1.0	1.0	0.5	-0.4	-0.4	-0.3	-0.4	-0.1
Body fat percentage	0.1	0.3	1.2	0.7	-0.6	-0.1	-0.0	0.4	0.4	-1.1
Leg fat percentage (right)	0.1	0.3	1.3	0.1	-0.8	-0.4	-0.2	-0.0	0.1	-1.1
Comparative body size at age 10	0.1	0.3	1.0	-0.7	-1.0	-0.5	-0.5	-0.4	-0.2	-0.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.2	0.3	-0.7	-0.2	-0.6	-0.6	-0.3
Medication: Omeprazole	0.1	0.1	0.2	0.1	-0.3	0.4	0.3	0.2	0.3	-0.1
Medication: Aspirin	0.1	0.1	0.7	-0.2	-0.8	0.2	0.1	0.1	0.4	0.3
Knee pain experienced in last month	0.1	0.2	0.6	-0.6	0.1	0.3	0.3	0.8	0.1	0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.5	0.1	-0.7	0.0	-0.2	0.0	-0.0	0.6
Arm fat percentage (left)	0.1	0.6	2.4	0.9	-0.4	-0.1	-0.1	0.6	0.6	-1.5
Average weekly red wine intake	0.1	0.1	0.5	-0.0	0.7	0.3	0.2	0.3	-0.0	-0.0
Ever had bowel cancer screening	0.1	0.1	0.3	-0.1	-0.2	0.1	-0.2	0.2	-0.6	0.4
Qualifications: nursing, teaching	0.1	0.1	0.3	0.6	0.3	-0.1	-0.3	0.1	0.2	-0.1
Medication for cholesterol	0.1	0.2	0.5	-0.4	0.1	-0.4	-0.7	-0.4	-0.0	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.5	0.0	0.1	-0.0	-0.0	0.3	-0.2	0.7
Medication: Blood pressure	0.1	0.2	0.5	-0.6	0.3	0.1	0.3	-0.1	-0.2	0.7
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.1	0.3	-0.4	-0.5	-0.1	-0.5	0.4
Medication: Lisinopril	0.1	0.2	0.5	-0.4	-0.7	0.2	0.2	0.3	0.5	0.1
Leg fat percentage (left)	0.1	0.4	1.7	-0.1	-0.8	-0.6	-0.5	-0.2	-0.0	-1.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.2	-0.4	-0.2	-0.5	0.1	-0.0	0.4
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.0	-0.4	0.4	0.4	-0.1	0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.6	-0.2	-0.8	-0.1	-0.3	-0.1	0.2	-0.4
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	0.0	-0.3	0.0	-0.0	-0.1	0.5	0.1
Blood Red Count	0.0	0.1	0.3	0.1	-0.5	-0.0	-0.1	0.0	-0.1	-0.3
Hypothyroidism (self reported)	0.0	0.1	0.4	-0.6	-0.3	0.0	-0.3	-0.4	-0.1	-0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	-0.0	-0.0	0.2	0.0	-0.0	-0.3	0.3
Hypertension (Self-reported)	0.0	0.1	0.7	0.0	-0.2	-0.1	-0.2	0.0	-0.3	0.8

Hub : Genes

ARHGAP32

Models

Trait associations