Hub : Genes

ARHGAP32

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.2280 0.0730 6.2e-04 0.055 NA 0.066 NA 0.073 8.3e-04 NA 2.5e-04 NA 1.2e-04
2 GTEx Adrenal Gland 0.1893 0.0678 1.3e-03 0.170 NA 0.071 NA 0.145 1.1e-06 NA 1.6e-03 NA 7.0e-06
3 GTEx Cells Transformed fibroblasts 0.2330 0.0460 3.9e-09 0.161 NA 0.158 NA 0.151 3.9e-12 NA 6.0e-12 NA 2.1e-11
4 GTEx Heart Atrial Appendage 0.3870 0.0800 1.1e-06 0.183 NA 0.090 NA 0.128 1.2e-08 NA 7.3e-05 NA 2.4e-06
5 GTEx Nerve Tibial 0.4350 0.0503 0.0e+00 0.394 NA 0.351 NA 0.406 1.3e-29 NA 8.5e-26 NA 1.1e-30
6 TCGA Head and Neck Squamous Cell Carcinoma 0.0422 0.0224 7.6e-04 0.009 0.022 0.016 NA 0.016 2.7e-02 0.0013 5.7e-03 NA 5.8e-03
7 TCGA Thyroid Carcinoma 0.0580 0.0310 4.9e-03 -0.002 0.015 0.019 NA 0.004 5.6e-01 0.0120 4.9e-03 NA 1.2e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.7 1.9 -1.4 -1.4 -0.1 0.0 -0.8 0.2 0.6
Bipolar Disorder or Schizophrenia 0.5 1.2 4.6 -1.1 -2.2 -0.5 -0.1 -1.2 0.9 -0.5
Depressed Affect (Nagel 2018) 1.2 2.5 7.6 -2.8 -2.4 0.4 0.8 0.1 0.7 1.7
Depression (Nagel 2018) 0.7 1.1 2.2 -0.3 -1.2 0.9 1.2 1.5 1.3 0.0
Intelligence (Savage-Jansen 2018) 0.2 0.5 2.0 0.1 -1.4 0.5 0.2 0.2 0.9 0.2
Neuroticism (Nagel 2018) 0.9 2.1 6.2 -2.5 -2.5 0.4 0.5 0.4 1.0 1.1
Schizophrenia (2018) 0.4 0.8 2.8 -0.2 -1.7 -0.6 -0.1 -1.0 1.0 -0.8
Schizophrenia vs Biploar Disorder 0.8 1.1 3.0 0.6 -0.9 0.5 0.8 0.6 1.7 -1.5
Worry (Nagel 2018) 0.5 1.1 3.4 -1.7 -1.8 0.1 -0.1 -0.0 0.7 0.8
Alzheimer’s Disease (in mother) 0.6 0.7 2.5 -0.7 -1.6 -0.5 -0.1 -0.4 0.7 -0.9
Alzheimer’s Disease (in father) 0.5 0.5 2.4 0.2 1.5 -0.2 0.0 0.0 -0.4 -1.0
Alzheimer’s Disease (including proxy) 0.3 0.4 1.6 -0.4 -0.3 -0.7 -0.3 -0.7 -0.1 -1.3
Crohns Disease (2017) 0.1 0.3 1.1 -1.1 -0.6 -0.1 -0.2 -0.5 0.0 0.2
Irritable Bowel Disease (IBD) 0.0 0.1 0.3 0.0 -0.3 0.0 -0.0 -0.1 0.5 0.1
Ulcerative Colitis (UC) 0.2 0.4 1.5 0.7 -0.3 0.6 0.5 0.5 1.2 0.0
Major Depression (MDD) 0.8 1.0 2.5 0.8 -1.1 0.8 0.4 1.0 1.6 -1.0
Reaction Time 0.2 0.4 1.0 -0.9 -0.4 0.6 1.0 0.4 0.7 -0.3
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.8 1.5 -1.2 1.1 0.6 0.9 1.7 0.5
Breast Cancer 0.2 0.4 0.9 0.7 -0.9 0.4 0.7 0.2 0.7 -0.8
Ovarian Cancer 0.1 0.1 0.4 0.2 0.0 -0.6 -0.2 -0.4 -0.3 0.5
Prostate Cancer 0.9 1.3 2.5 1.0 0.1 1.3 1.1 1.5 1.6 -0.5
Age at First Birth 0.2 0.3 1.8 -1.3 -0.0 -0.2 0.0 0.0 0.0 0.7
Bipolar Disorder (2011) 0.3 0.3 1.3 -1.2 -0.7 0.1 0.3 0.0 -0.3 0.2
Body Mass Index (BMI) (2010) 1.8 2.4 5.8 -2.4 -0.9 -1.7 -1.4 -1.9 -1.2 0.3
Coronary Artery Disease (CAD) 0.2 0.2 0.3 -0.6 0.5 -0.4 -0.3 -0.5 0.4 -0.3
Crohns Disease (2012) 0.3 0.4 1.3 -1.2 -1.0 -0.1 0.0 0.1 0.7 -0.4
Mean Putamen Volume 0.1 0.1 0.3 0.1 0.4 0.1 -0.2 0.6 0.2 -0.2
Fasting Glucose 0.7 0.9 3.6 -0.1 1.9 -0.5 -1.0 0.1 -1.1 -0.3
HbA1C 1.5 1.6 2.3 -0.8 0.9 -1.5 -1.4 -1.5 -1.4 -1.2
HDL Cholesterol 1.0 1.7 5.2 2.3 -0.5 1.0 0.9 1.4 1.7 -0.6
LDL Cholesterol 0.8 1.3 2.2 -1.0 -0.7 -1.1 -1.4 -1.2 -0.7 -1.5
Lupus 0.3 0.5 2.5 0.9 -0.2 -0.0 -0.1 -0.5 0.2 -1.6
Neuroticism (2016) 0.1 0.2 0.5 -0.7 -0.7 -0.3 -0.0 -0.1 -0.4 0.0
Primary Biliary Cirrhosis 0.9 1.3 2.5 -1.0 -0.9 1.6 1.4 1.1 1.1 0.3
Rheumatoid Arthritis 1.6 2.2 3.4 0.6 -1.6 1.7 1.8 1.6 1.6 0.9
Schizophrenia (2014) 0.4 0.9 1.9 -1.2 -1.4 -0.7 -0.4 -1.3 0.7 -0.4
Triglycerides 1.2 2.0 5.7 -2.4 -1.0 -1.0 -0.9 -1.9 -1.4 0.4
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.7 -1.6 -0.7 -0.1 -0.7 -0.1 0.6 1.5
Ulcerative Colitis 0.4 0.5 1.9 0.1 -0.9 -0.5 -0.0 -0.4 0.8 -1.4
Blood Eosinophil Count 0.3 2.0 4.8 -2.2 1.2 -1.3 -1.0 -1.3 -1.6 -0.5
Blood Platelet Count 1.2 14.4 31.2 1.1 5.2 -3.9 -3.1 -3.0 -5.6 -2.9
Blood Red Count 0.0 0.1 0.3 0.1 -0.5 -0.0 -0.1 0.0 -0.1 -0.3
Blood White Count 0.4 3.1 10.7 -3.3 -3.0 -0.6 -0.7 -1.1 0.2 -0.8
Heel T-Score 0.6 4.4 8.9 -0.7 -0.1 -2.7 -3.0 -2.9 -2.4 -0.6
BMI 0.2 1.2 2.4 1.6 -1.4 0.8 0.2 1.0 1.5 -0.3
Height 2.0 38.6 69.6 3.6 -2.8 8.3 7.9 7.5 6.6 4.3
Waist Hip Ratio (WHR) 0.1 0.6 1.6 0.4 0.5 -1.0 -0.4 -0.9 -1.2 0.4
Systolic Blood Pressure 0.8 4.0 6.6 0.9 2.6 -2.1 -2.2 -1.8 -2.5 -1.4
Smoking Status 0.4 0.9 2.0 -1.1 -0.3 0.9 1.1 0.8 0.4 1.4
Allergy or Eczema 1.7 4.4 9.0 -1.7 2.0 -2.3 -1.6 -1.0 -3.0 -2.4
Cardiovascular Disease 0.1 0.4 1.9 0.3 0.4 0.0 -0.3 0.2 -0.6 1.4
Hypothyroidism (self reported) 0.0 0.1 0.4 -0.6 -0.3 0.0 -0.3 -0.4 -0.1 -0.1
Respiratory disease 1.0 2.2 3.5 -0.4 -1.7 1.9 1.6 1.4 1.9 0.8
Type 2 Diabetes (T2D) (2018) 1.0 1.8 3.7 -0.6 -1.9 1.1 1.5 1.1 1.6 1.1
Lung FEV1/FVC ratio 0.3 1.5 2.2 0.8 1.2 -1.5 -1.5 -1.2 -1.1 -1.3
Lung FVC 0.4 1.8 3.5 -0.8 0.9 -1.4 -1.0 -1.2 -1.9 1.8
Neuroticism 0.6 1.5 4.7 -2.2 -1.9 -0.8 -1.0 -0.7 -0.2 0.3
Chronotype (morning person) 0.9 2.1 7.1 1.9 2.7 0.6 1.0 1.0 -0.4 -1.2
Hair Pigment 0.3 9.2 14.9 2.2 1.1 3.9 3.7 3.8 3.7 1.2
Tanning 0.1 1.3 3.5 -1.2 1.9 -0.6 -0.4 -0.6 -1.7 0.3
Hand grip strength (left) 0.2 0.4 1.6 0.8 0.4 0.4 0.3 0.3 0.0 1.3
Number of treatments/medications taken 1.1 2.0 9.9 -1.6 -3.1 0.3 0.1 0.5 1.1 0.3
Average weekly spirits intake 0.9 1.1 2.6 0.5 -1.6 0.9 0.3 1.1 1.6 0.4
Sensitivity / hurt feelings 1.0 1.7 5.1 -2.3 -2.1 0.7 0.7 0.4 1.1 0.2
Frequency of depressed mood in last 2 weeks 1.5 2.1 3.5 -1.0 -1.9 1.4 1.8 1.5 1.4 0.8
Hearing difficulty/problems: Yes 2.5 3.8 8.9 -0.1 2.5 -2.0 -2.1 -1.8 -3.0 -0.1
Relative age of first facial hair 0.4 0.8 2.0 -0.8 0.4 -1.0 -1.4 -0.9 -0.5 -0.8
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 4.3 0.1 -0.4 1.8 1.6 1.9 2.1 1.4
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.3 -1.5 -0.0 -0.3 0.0 -0.8 -1.2 0.0
Ever had hysterectomy (womb removed) 0.8 1.0 1.9 -0.3 -0.5 1.4 1.3 1.1 0.6 1.0
Systolic blood pressure, automated reading 0.5 1.5 2.3 1.2 1.2 -1.3 -1.5 -0.8 -1.5 -0.8
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 4.1 -0.2 -0.8 1.5 2.0 1.8 1.4 -0.3
Angina 0.6 0.8 2.8 -1.7 -0.8 0.5 0.5 0.4 1.0 0.3
Medication for hormone replacement therapy 0.2 0.2 0.8 0.7 -0.4 -0.0 0.5 0.0 0.1 -0.9
Vitamin and mineral supplements 2.0 2.7 5.3 2.0 1.6 1.7 1.6 2.3 1.1 0.1
Supplements: Zinc 0.6 0.6 1.0 -0.2 -1.0 -0.9 -1.0 -1.0 -0.5 0.5
Medication: Co-codamol 1.9 2.2 4.5 -1.0 -1.4 1.8 1.8 1.2 2.1 0.6
Medication: Metformin 0.8 1.1 4.4 -0.1 -2.1 0.5 0.6 0.6 1.6 0.2
Diabetes (father) 1.9 2.4 4.6 0.4 2.1 -1.6 -1.5 -1.4 -1.8 -1.4
Diabetes (mother) 0.9 1.1 1.8 -0.9 0.3 -1.1 -0.9 -1.2 -1.3 1.4
Severe depression (siblings) 0.6 0.7 3.7 -0.4 0.1 -0.5 -0.9 -0.2 -0.3 -1.9
Pack years adult smoking proportion 0.6 0.9 1.6 -0.1 0.3 -1.3 -0.7 -1.2 -1.1 -1.2
Impedance of leg (right) 0.7 3.2 7.6 -1.6 2.4 -1.7 -1.0 -1.5 -2.8 -0.5
Leg fat-free mass (left) 1.8 9.6 17.5 3.1 -2.1 3.7 3.1 3.3 4.2 0.9
Trunk fat percentage 0.1 0.4 0.9 0.9 -0.3 0.2 0.3 0.7 0.5 -1.0
Hand grip strength (right) 0.3 0.9 5.2 0.3 -0.2 0.9 0.6 0.1 -0.0 2.3
Townsend deprivation index at recruitment 0.5 0.7 3.0 -1.7 -0.1 -0.2 0.4 -0.7 -0.7 0.7
Current tobacco smoking 0.5 0.8 2.6 -1.6 0.1 -0.8 -0.3 -1.0 -1.2 0.3
Average weekly fortified wine intake 1.0 1.2 2.4 -0.9 -1.6 -1.0 -1.1 -1.1 -0.6 1.2
Maternal smoking around birth 1.7 2.5 5.6 -2.4 -0.9 -1.6 -1.6 -2.1 -1.3 0.1
Fed-up feelings 0.6 1.0 2.8 -1.6 -1.7 0.4 0.6 0.6 0.7 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.7 -0.3 0.4 -0.6 0.1 0.0 -0.8 -0.6
Relative age voice broke 0.3 0.4 1.2 -0.1 -0.2 1.1 0.5 0.7 0.9 0.3
Taking other prescription medications 2.1 3.3 9.8 -3.0 -3.1 0.2 0.4 0.3 0.8 1.8
Age when periods started (menarche) 1.6 3.8 7.3 1.1 2.7 -2.2 -1.8 -1.6 -1.8 -2.0
Bilateral oophorectomy (both ovaries removed) 2.7 3.2 5.2 0.7 -0.6 2.1 2.3 2.3 2.0 1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.9 0.4 1.0 -0.8 -0.7 -0.7 -1.4 0.3
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 2.3 -1.1 0.2 -1.5 -1.3 -1.1 -1.5 -0.6
Qualifications: CSEs or equivalent 0.2 0.2 0.9 0.6 1.0 -0.5 -0.1 0.0 -0.0 -0.2
Serious illness, injury or assault to yourself 0.1 0.1 0.3 -0.4 -0.5 -0.1 0.2 0.2 -0.1 0.3
High blood pressure 0.1 0.1 0.6 0.3 0.2 0.1 0.0 0.3 -0.5 0.8
Hayfever, allergic rhinitis or eczema 2.1 4.5 8.1 -1.4 1.8 -2.5 -1.7 -1.6 -2.9 -2.6
Multivitamins +/- minerals 2.3 2.9 6.6 -1.9 -2.6 -1.6 -1.4 -2.1 -0.7 -0.7
Stomach or abdominal pain in last month 1.4 1.8 3.3 -1.1 0.6 -1.5 -1.6 -1.1 -1.1 -1.8
Supplements: Glucosamine 1.6 2.1 3.5 -1.7 -0.9 -1.7 -1.7 -1.9 -0.9 -0.7
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 3.4 0.4 1.9 0.2 -0.2 -0.3 -1.1 0.4
Medication: Atenolol 0.1 0.2 0.5 -0.2 0.7 -0.2 0.2 -0.3 -0.5 -0.5
Medication: Levothyroxine sodium 0.2 0.4 0.6 0.8 0.6 -0.4 -0.8 -0.3 -0.6 -0.5
Sitting height 2.1 14.9 25.9 3.9 -0.7 5.1 4.6 4.4 4.7 0.7
Chronic bronchitis/emphysema (father) 0.9 1.1 3.7 1.9 1.5 0.0 -0.2 0.5 -0.8 -0.8
High blood pressure (mother) 0.4 0.6 1.6 0.1 1.3 -0.6 -0.8 -0.7 -0.7 -0.6
Body mass index (BMI) 0.2 1.0 2.2 1.0 -1.5 0.5 0.2 0.8 1.4 -0.9
Impedance of leg (left) 0.8 3.7 8.3 -1.8 2.4 -2.0 -1.2 -1.7 -2.9 -0.7
Leg predicted mass (left) 1.8 9.4 17.2 3.0 -2.1 3.7 3.1 3.3 4.1 0.9
Trunk fat mass 0.4 1.9 2.9 1.6 -1.1 1.4 1.2 1.6 1.7 -0.6
Waist circumference 0.5 1.9 3.3 1.6 -1.4 1.3 1.1 1.4 1.8 -0.4
Number of incorrect matches in round 1.7 2.9 7.1 -2.6 -2.7 0.6 1.0 -0.0 0.4 2.2
Past tobacco smoking 1.6 3.0 4.8 0.9 1.4 -2.0 -1.8 -2.0 -2.2 -1.6
Alcohol usually taken with meals 0.1 0.2 0.6 -0.8 -0.4 0.4 0.1 0.1 0.7 0.1
Nervous feelings 0.8 1.5 3.2 -0.9 0.1 -1.6 -1.2 -1.8 -1.4 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.6 -1.3 -0.3 -0.6 -0.1 -0.1 -0.8 -0.1
Hearing difficulty/problems with background noise 0.7 1.1 5.6 0.7 2.4 -0.4 -0.5 0.1 -1.0 -0.7
Hair/balding pattern: Pattern 2 0.6 0.8 1.9 0.7 1.1 0.8 0.8 0.6 0.0 1.4
Had menopause 0.2 0.3 1.4 -1.2 -0.6 0.2 -0.0 -0.2 0.2 0.3
Had other major operations 0.8 1.0 3.8 -1.9 -0.4 -0.6 -0.6 -1.1 -0.9 0.3
Forced vital capacity (FVC) 0.9 3.4 8.0 2.8 1.5 2.1 1.9 1.7 0.9 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.5 0.1 0.4 -0.7 -0.7 -0.9 -1.1 1.6
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 4.0 1.3 0.9 -0.5 -0.4 0.3 -0.3 -2.0
Qualifications: None of the above 0.5 1.2 6.2 -2.5 -0.6 -0.5 0.2 -0.8 -0.7 0.3
Financial difficulties in last 2 years 2.1 2.8 7.4 -2.7 -2.7 -1.2 -0.6 -1.8 0.3 -0.1
Mouth/teeth dental problems 0.4 0.7 2.3 1.5 1.1 0.2 -0.2 0.1 -0.4 -0.9
Heart attack 0.4 0.5 2.7 0.3 1.6 0.4 0.8 0.3 -0.0 0.4
Allergy 0.6 1.3 3.2 1.4 -1.0 0.9 0.3 0.3 1.6 1.8
Pain all over the body in last month 1.4 1.5 5.4 -0.6 -2.3 0.8 0.4 0.1 1.2 1.7
Diabetes (self-reported) 1.3 2.0 6.1 -1.9 -2.5 0.6 1.1 0.7 1.5 0.1
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 7.7 -2.8 -2.1 -1.2 -0.9 -1.2 0.2 -2.2
Medication: Ramipril 0.3 0.4 1.7 -1.3 -0.7 -0.4 0.1 -0.1 0.0 0.7
Medication: Simvastatin 0.9 1.3 3.6 0.6 -1.1 0.9 0.5 0.7 1.9 -1.6
Fluid intelligence score 0.9 1.9 3.6 0.3 -1.2 1.6 1.4 1.2 1.9 1.3
Illnesses of siblings 0.3 0.4 0.9 -0.9 -0.4 0.5 0.8 0.3 0.2 0.9
Neuroticism score 0.8 1.6 5.5 -2.3 -2.1 -0.4 -0.4 -0.5 0.3 0.6
Weight 1.3 6.5 12.0 2.3 -2.0 3.0 2.6 2.8 3.5 0.4
Impedance of arm (right) 1.1 5.1 14.4 -0.9 3.8 -2.0 -1.3 -1.4 -3.2 -1.6
Arm fat percentage (right) 0.2 0.7 3.7 0.8 -0.3 -0.5 -0.6 0.2 0.2 -1.9
Trunk fat-free mass 1.9 10.9 19.7 2.8 -2.7 4.1 3.3 3.5 4.4 1.1
Hip circumference 0.7 3.2 5.6 1.7 -1.6 2.0 1.8 1.8 2.4 -0.8
Time employed in main current job 2.5 2.9 5.7 -0.6 1.0 -1.8 -2.4 -2.0 -1.7 -1.6
Alcohol intake versus 10 years previously 0.4 0.5 1.1 -0.4 0.3 0.8 1.0 0.8 0.9 -0.1
Father’s age at death 0.4 0.5 1.9 0.5 1.4 -0.5 -0.7 0.1 -0.7 0.2
Worrier / anxious feelings 0.9 1.6 3.6 -1.6 -1.7 0.8 0.2 0.9 1.0 1.9
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.3 -0.5 -0.3 0.8 1.2 1.0 1.0 1.1
Falls in the last year 1.2 1.7 4.4 -0.8 1.7 -1.4 -0.9 -1.0 -2.1 -0.0
Hair/balding pattern: Pattern 3 0.4 0.5 1.3 -0.6 -0.9 0.6 0.3 0.7 0.6 1.1
Number of live births 2.5 3.6 5.8 -1.4 1.0 -2.3 -2.3 -2.4 -1.6 -1.7
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 8.4 2.9 2.0 1.2 1.0 1.0 0.2 0.7
Pulse rate 2.9 4.8 14.1 -1.3 -3.8 2.0 1.9 1.6 2.5 1.3
Happiness 0.3 0.4 1.5 1.2 0.3 -0.5 -0.2 -0.1 0.1 -0.8
Noisy workplace 1.1 1.3 2.5 -1.0 0.9 -1.6 -1.4 -1.0 -1.2 -0.6
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.8 1.0 0.4 1.1 0.8 1.0 1.3 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.9 0.7 1.0 -0.4 -0.0 -0.8 -0.7 -0.1
Mouth/teeth dental problems: Dentures 0.7 1.2 5.7 -2.4 -1.4 -0.3 0.0 -0.6 0.1 -0.1
Asthma 0.4 0.7 2.0 -1.4 -0.8 0.9 0.8 0.7 0.5 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.1 3.6 1.2 -1.1 1.7 1.9 1.7 1.2 0.8
Medication: Cholesterol lowering 0.2 0.3 0.8 0.5 -0.9 -0.0 -0.4 0.0 0.8 -0.5
Depression (self-reported) 0.7 0.8 2.0 -0.7 -1.4 0.2 0.1 0.7 1.4 0.9
Medication: Lansoprazole 0.9 1.0 2.2 1.0 0.7 1.2 0.7 1.5 1.1 0.3
Prospective memory result 3.8 4.7 7.5 1.2 -1.5 2.6 2.7 2.7 2.3 1.7
Lung cancer (father) 2.0 2.3 9.4 -3.1 -2.3 -0.8 -0.5 -0.9 0.2 -0.1
Illnesses of mother 0.1 0.1 0.6 0.3 -0.4 -0.0 -0.1 -0.0 -0.0 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 5.1 2.3 1.6 1.3 1.2 0.9 -0.1 1.3
Pulse wave Arterial Stiffness index 0.7 0.8 1.5 1.2 -0.7 0.9 0.7 0.9 0.8 0.9
Impedance of arm (left) 0.7 3.4 14.1 -0.7 3.8 -1.2 -0.5 -0.6 -2.5 -0.9
Arm fat mass (right) 0.4 1.5 3.0 1.6 -1.2 0.8 0.6 1.1 1.7 -1.2
Trunk predicted mass 1.9 10.7 19.4 2.7 -2.6 4.1 3.3 3.5 4.4 1.1
Standing height 1.7 17.1 32.6 3.2 -0.9 5.7 5.3 4.7 4.6 2.4
Length of working week for main job 2.5 2.8 4.6 -0.5 0.9 -2.1 -2.1 -1.9 -1.9 -1.6
Exposure to tobacco smoke at home 0.2 0.2 1.3 -0.5 -1.1 0.2 0.2 0.1 0.1 0.2
Breastfed as a baby 0.4 0.5 1.8 0.5 -1.2 0.4 0.1 0.3 1.3 0.1
Tense / ‘highly strung’ 0.7 1.2 3.2 -1.8 -1.8 -0.8 -0.5 -0.8 0.5 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.1 -0.9 -0.3 -0.9 -0.8 -0.2 0.4 -1.1
Hair/balding pattern: Pattern 4 0.7 1.7 4.3 -0.6 -0.0 1.6 2.1 1.5 0.2 1.6
Birth weight of first child 0.1 0.1 0.4 0.6 -0.0 0.4 0.2 0.2 0.2 0.3
Peak expiratory flow (PEF) 2.8 6.6 13.8 3.2 3.7 -1.9 -1.8 -1.6 -2.8 -2.3
Pulse wave reflection index 0.7 0.9 3.2 1.8 1.1 0.4 0.3 0.5 -0.2 1.2
Ever highly irritable/argumentative for 2 days 1.1 1.3 4.2 0.0 1.7 -0.9 -0.3 -0.2 -1.0 -2.0
Loud music exposure frequency 0.2 0.2 0.9 0.3 -0.9 -0.4 -0.5 -0.3 0.2 0.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.9 0.5 -0.2 0.5 0.0 0.7 0.8 0.9
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.4 -0.2 0.1 -0.3 -0.2 -0.2 0.2 -0.6
Blood clot in the leg (DVT) 1.0 1.3 2.1 0.8 0.2 1.4 1.5 1.2 1.0 1.4
Medication: Paracetamol 1.6 2.6 7.0 -0.9 -2.7 1.4 1.6 1.4 1.2 1.6
Headache pain in last month 0.6 1.0 5.2 -0.0 0.8 -0.6 -0.8 0.3 -0.2 -2.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.5 -0.5 1.2 -0.9 -0.5 -0.9 -1.0 -0.5
Glaucoma (self-reported) 0.1 0.1 0.3 0.5 0.2 0.1 -0.2 0.3 0.3 -0.5
Gout (self-reported) 1.5 2.1 4.5 -0.8 -2.1 1.4 0.9 1.3 2.0 1.1
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.1 -0.0 -0.0 0.2 0.0 -0.0 -0.3 0.3
Medication: Amlodipine 0.5 0.8 2.6 1.6 1.4 -0.1 -0.4 0.6 -0.5 0.0
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.7 0.3 -0.5 0.4 0.1 0.2 0.1 0.8
Birth weight 0.1 0.2 1.0 1.0 0.5 -0.4 -0.4 -0.3 -0.4 -0.1
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.7 -0.2 0.6 -0.2 0.3 -0.1 -0.1 -0.8
High blood pressure (siblings) 0.6 0.8 2.2 1.5 -0.1 0.9 0.7 0.8 1.3 -0.4
Forced vital capacity (FVC), Best measure 0.9 3.2 5.2 2.3 1.3 2.3 2.0 1.6 0.8 1.8
Body fat percentage 0.1 0.3 1.2 0.7 -0.6 -0.1 -0.0 0.4 0.4 -1.1
Leg fat percentage (right) 0.1 0.3 1.3 0.1 -0.8 -0.4 -0.2 -0.0 0.1 -1.1
Arm fat-free mass (right) 2.5 12.9 23.4 2.6 -3.3 4.4 3.7 3.6 4.8 1.8
Exposure to tobacco smoke outside home 0.7 0.9 2.3 -0.1 -1.2 0.7 1.0 1.2 1.5 -0.1
Comparative body size at age 10 0.1 0.3 1.0 -0.7 -1.0 -0.5 -0.5 -0.4 -0.2 -0.0
Number of full brothers 0.7 0.9 3.0 1.7 1.7 0.2 0.2 0.6 -0.1 -0.3
Worry too long after embarrassment 1.1 1.9 6.5 -2.5 -1.9 -0.7 -1.0 -0.8 0.4 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 1.3 -0.9 -0.1 -0.5 0.0 -0.1 -0.1 -1.1
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 -0.2 0.3 -0.7 -0.2 -0.6 -0.6 -0.3
Number of children fathered 1.2 1.3 2.5 -0.8 -0.3 -1.3 -1.5 -1.6 0.0 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 4.8 -0.4 -1.5 1.3 1.4 0.9 1.2 2.2
Age at first live birth 0.9 1.6 7.5 2.7 1.4 0.4 0.3 0.5 -0.5 0.9
Pulse wave peak to peak time 0.3 0.3 0.8 -0.9 0.4 -0.4 -0.2 -0.4 -0.4 -0.7
Health satisfaction 1.0 1.2 2.1 -1.4 -0.1 -1.4 -1.4 -1.4 -0.3 -0.9
Shortness of breath walking on level ground 0.5 0.6 2.8 0.4 0.8 0.1 0.3 0.4 0.8 -1.7
Qualifications: College or University degree 0.9 2.8 14.1 3.8 1.9 0.8 0.2 0.9 0.5 -0.7
Eye problems/disorders: None of the above 0.2 0.2 0.9 -0.5 -0.2 -0.3 -0.1 -0.9 -0.3 0.6
Mouth/teeth dental problems: Loose teeth 1.1 1.3 3.4 -1.0 -0.5 -1.2 -1.5 -0.9 -0.0 -1.8
Emphysema/chronic bronchitis 0.2 0.2 0.5 -0.6 -0.7 -0.1 -0.5 0.3 0.4 0.4
Medication for pain relief, constipation, heartburn 1.2 2.0 8.0 1.4 2.8 -0.8 -0.6 -1.0 -1.0 -1.1
Neck or shoulder pain in last month 0.3 0.4 0.8 -0.5 -0.6 0.6 0.1 0.8 0.9 0.6
Medication: Blood pressure 0.8 1.4 2.2 1.2 -1.4 1.1 0.7 1.4 1.5 0.8
Angina (self-reported) 0.5 0.7 2.2 -1.5 -0.8 0.5 0.6 0.4 1.0 0.3
Migraine (self-reported) 1.0 1.2 2.5 -1.6 -1.2 -1.0 -1.3 -0.9 -0.2 0.9
Medication: Ibuprofen 0.8 0.9 2.1 0.5 -0.7 1.2 1.4 1.1 0.6 0.7
Medication: Allopurinol 1.0 1.3 3.3 -0.2 -1.8 1.0 0.3 1.1 1.8 0.4
Medication: Omeprazole 0.1 0.1 0.2 0.1 -0.3 0.4 0.3 0.2 0.3 -0.1
Medication: Seretide 50 evohaler 0.2 0.2 0.7 -0.4 0.6 -0.1 0.1 -0.4 -0.8 0.4
Mean time to correctly identify matches 0.3 0.6 1.3 -1.1 -1.0 0.6 1.1 0.4 0.4 0.4
Heart disease (mother) 0.8 0.9 2.1 -0.3 -0.3 1.4 1.4 0.9 0.8 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 4.5 -0.5 1.2 -2.1 -1.6 -1.7 -2.1 -0.6
Whole body fat mass 0.3 1.4 2.5 1.3 -1.2 1.1 0.9 1.2 1.6 -0.6
Leg fat mass (right) 0.4 1.6 3.3 1.2 -1.6 1.1 1.0 1.2 1.8 -0.7
Arm predicted mass (right) 2.4 12.5 23.6 2.3 -3.4 4.4 3.6 3.5 4.9 1.8
Pulse rate, automated reading 1.8 5.8 16.9 -0.2 -4.1 2.3 2.0 1.9 2.6 2.0
Alcohol intake frequency. 0.3 0.8 1.3 -0.8 1.0 -1.1 -0.5 -1.1 -1.1 0.3
Comparative height size at age 10 1.2 6.6 11.6 2.9 -0.1 3.4 3.2 3.2 2.4 0.5
Number of full sisters 0.7 0.8 4.2 -0.5 1.0 -0.5 -0.4 0.0 -0.3 -2.0
Suffer from ‘nerves’ 0.5 0.8 2.7 -1.2 -1.6 0.2 0.0 0.0 1.3 0.0
Overall health rating 0.5 1.1 2.7 -0.6 -0.5 1.1 1.0 1.0 1.2 1.7
Chest pain or discomfort 1.5 2.1 8.2 -2.9 -1.9 -1.1 -0.8 -1.2 -0.0 0.1
Had major operations 1.3 1.6 3.1 1.6 -0.3 1.4 1.4 1.2 1.8 0.2
Age at last live birth 0.9 1.3 4.9 2.2 1.9 0.0 -0.0 0.2 -0.0 -0.8
Family relationship satisfaction 0.7 0.9 2.0 0.4 1.1 -0.8 -0.6 -0.8 -1.1 -1.4
Leg pain on walking 0.3 0.4 1.7 -1.3 -0.3 -0.7 -0.7 -0.1 0.0 0.4
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 4.9 -0.7 1.0 -1.6 -1.0 -1.3 -2.2 -0.3
Commuting to job workplace: Car/motor vehicle 3.2 3.6 7.4 -0.5 -2.7 1.8 2.1 1.6 2.1 1.8
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.5 1.1 1.2 0.1 -0.2 0.6 -0.6 0.8
Medication: Aspirin 0.1 0.1 0.7 -0.2 -0.8 0.2 0.1 0.1 0.4 0.3
Supplements: Vitamin C 1.9 2.2 4.6 -1.5 -0.5 -1.5 -1.7 -2.1 -1.4 1.1
Knee pain experienced in last month 0.1 0.2 0.6 -0.6 0.1 0.3 0.3 0.8 0.1 0.4
Hypertension (Self-reported) 0.0 0.1 0.7 0.0 -0.2 -0.1 -0.2 0.0 -0.3 0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.8 -0.8 -0.3 -1.0 -0.9 -0.3 -0.7 -1.3
Illnesses of father: Heart disease 0.2 0.2 1.1 0.6 0.3 -0.2 -0.1 -0.4 0.0 -1.0
Illnesses of siblings: Diabetes 0.1 0.1 0.5 0.1 -0.7 0.0 -0.2 0.0 -0.0 0.6
Smoking status: Previous 2.6 3.9 5.5 -0.6 -2.1 2.0 1.8 2.1 2.4 2.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 0.9 2.4 0.6 -0.4 1.5 1.4 0.9 0.8 0.4
Whole body fat-free mass 2.0 11.6 21.4 2.9 -2.8 4.2 3.4 3.6 4.6 1.2
Leg fat-free mass (right) 1.8 9.7 18.1 2.8 -2.3 3.8 3.2 3.3 4.3 1.1
Arm fat percentage (left) 0.1 0.6 2.4 0.9 -0.4 -0.1 -0.1 0.6 0.6 -1.5
Average weekly red wine intake 0.1 0.1 0.5 -0.0 0.7 0.3 0.2 0.3 -0.0 -0.0
Handedness (chirality/laterality): Left-handed 1.2 1.5 2.9 0.4 1.7 -1.2 -1.0 -0.8 -1.4 -1.5
Mood swings 1.5 2.7 6.7 -2.5 -2.6 0.4 0.8 0.2 0.5 2.2
Loneliness, isolation 1.6 2.2 10.3 -3.2 -1.9 -0.6 -0.0 -0.6 -0.7 0.7
Long-standing illness, disability or infirmity 0.7 1.0 3.1 -0.4 0.0 1.1 1.8 1.3 1.0 -0.1
Ever had bowel cancer screening 0.1 0.1 0.3 -0.1 -0.2 0.1 -0.2 0.2 -0.6 0.4
Diabetes diagnosed by doctor 0.8 1.3 3.7 -1.5 -1.9 0.5 1.1 0.7 1.3 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.1 3.8 -0.5 0.1 -1.9 -1.8 -1.9 -1.4 -1.4
Friendships satisfaction 1.9 2.3 3.8 -0.2 1.3 -1.9 -1.7 -1.4 -1.5 -1.8
Qualifications: nursing, teaching 0.1 0.1 0.3 0.6 0.3 -0.1 -0.3 0.1 0.2 -0.1
Commuting to job workplace: Walk 0.3 0.3 0.7 0.8 0.3 -0.6 -0.8 -0.5 -0.5 -0.0
Eye problems/disorders: Cataract 2.1 2.5 5.1 -0.8 0.4 -1.8 -2.0 -1.6 -1.2 -2.3
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 5.7 -1.0 -2.4 0.2 0.5 0.1 1.2 1.0
Medication for cholesterol 0.1 0.2 0.5 -0.4 0.1 -0.4 -0.7 -0.4 -0.0 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 4.0 -0.6 -2.0 1.5 1.2 1.3 1.6 1.4
Back pain experienced in last month 0.8 1.2 2.2 -1.2 -1.2 0.9 1.5 0.4 1.4 0.6
Mineral and other dietary supplements 0.6 0.8 1.9 1.2 1.4 0.9 0.5 0.9 0.4 0.2
Breast cancer (self-reported) 2.6 3.1 7.5 -1.9 -2.7 -1.5 -2.0 -1.9 0.3 -0.9
Asthma (self-reported) 0.2 0.5 1.8 -1.4 -0.4 0.7 0.6 0.5 0.2 -0.4
Osteoporosis (self-reported) 0.1 0.1 0.5 0.0 0.1 -0.0 -0.0 0.3 -0.2 0.7
Osteoarthritis (self-reported) 0.2 0.2 0.6 -0.7 -0.6 -0.1 0.1 0.8 0.2 -0.4
Medication: Aspirin 0.2 0.3 0.8 -0.4 -0.9 0.3 0.2 0.1 0.6 0.6
Medication: Gliclazide 1.3 1.5 3.7 -1.4 -1.9 0.8 1.2 0.9 1.3 -0.0
Illnesses of father: None of the above (group 1) 1.4 1.8 7.1 -2.7 -0.9 -0.6 -0.5 -1.0 -0.5 1.6
Smoking status: Current 0.5 0.8 1.7 -1.3 0.6 -0.8 -0.4 -0.9 -1.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.7 0.2 -0.3 0.9 0.7 0.6 0.8 0.2
Whole body water mass 2.0 11.4 22.0 2.9 -2.8 4.1 3.3 3.5 4.7 1.1
Leg predicted mass (right) 1.8 9.4 17.8 2.7 -2.4 3.7 3.1 3.2 4.2 1.0
Arm fat mass (left) 0.5 1.9 3.8 1.5 -1.3 1.3 1.0 1.5 2.0 -0.7
Number of self-reported non-cancer illnesses 0.2 0.4 1.0 -1.0 -0.8 0.2 0.4 0.6 0.5 0.2
Average weekly champagne plus white wine intake 0.8 1.1 3.8 1.7 0.3 -0.4 -0.8 -0.7 -0.0 -1.9
Miserableness 0.9 1.5 5.1 -2.2 -2.0 -0.5 -0.5 -0.7 0.7 -0.1
Guilty feelings 0.5 0.7 1.6 -0.8 -0.5 -0.9 -1.2 -0.7 -0.9 -0.5
Wears glasses or contact lenses 2.7 3.1 5.7 0.3 -1.6 1.9 1.5 2.1 2.4 1.7
Ever taken oral contraceptive pill 0.7 0.8 1.8 -0.7 -0.3 -1.2 -1.1 -1.3 -0.7 0.1
Hearing aid user 1.0 1.1 2.9 -1.4 -0.2 -0.8 -0.5 -1.2 -1.7 0.9
Mother’s age at death 0.5 0.6 1.9 0.9 0.2 0.9 0.1 1.4 0.5 0.8
Financial situation satisfaction 1.2 1.5 3.5 -1.5 -1.9 -1.2 -1.2 -1.4 -0.2 0.4
Tinnitus: Yes, now most or all of the time 2.0 2.3 4.1 -2.0 -0.4 -1.8 -1.9 -1.9 -1.4 -0.3
Commuting to job workplace: Public transport 1.7 2.0 3.6 1.6 -0.3 1.8 1.7 1.3 1.9 0.6
Eye problems/disorders: Glaucoma 0.2 0.3 0.6 0.6 -0.6 0.3 0.2 0.3 0.8 0.3
Medication: Blood pressure 0.1 0.2 0.5 -0.6 0.3 0.1 0.3 -0.1 -0.2 0.7
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.5 -0.3 0.8 1.3 1.5 1.6 0.7 0.0
Supplements: Fish oil (including cod liver oil) 0.7 1.0 3.3 -1.6 -1.8 -0.5 -0.1 -0.7 -0.1 0.3
High cholesterol (Self-reported) 0.1 0.1 0.3 -0.1 0.3 -0.4 -0.5 -0.1 -0.5 0.4
Medication: Bendroflumethiazide 0.4 0.6 2.5 -1.6 -0.8 -0.1 0.3 -0.3 -0.8 0.2
Medication: Paracetamol 1.6 2.4 7.0 -1.2 -2.6 1.3 1.5 1.2 1.3 1.3
Medication: Lisinopril 0.1 0.2 0.5 -0.4 -0.7 0.2 0.2 0.3 0.5 0.1
Medication: Atorvastatin 1.1 1.4 2.1 0.5 -1.0 1.3 1.4 1.4 1.5 1.0
Illnesses of father: High blood pressure 1.3 1.6 5.4 2.3 -0.2 0.9 0.4 1.3 1.7 -0.6
Alcohol drinker status: Never 0.2 0.2 0.5 0.4 0.3 -0.5 -0.4 -0.3 -0.7 -0.4
Ever smoked 0.8 1.3 2.4 -1.0 -0.0 1.4 1.5 1.6 1.1 0.7
Basal metabolic rate 1.8 10.0 18.7 2.9 -2.5 3.9 3.2 3.4 4.3 0.8
Leg fat percentage (left) 0.1 0.4 1.7 -0.1 -0.8 -0.6 -0.5 -0.2 -0.0 -1.3
Arm fat-free mass (left) 1.7 8.6 17.8 2.4 -2.9 3.5 2.8 2.8 4.2 0.9
Number of operations (self-reported) 0.2 0.2 0.6 0.4 0.6 0.4 0.1 0.5 0.8 -0.4
Average weekly beer plus cider intake 0.4 0.6 0.9 0.9 -1.0 0.6 0.9 0.3 0.7 0.7
Irritability 0.4 0.7 3.1 -0.2 -0.5 -0.5 -0.5 -0.3 -0.9 1.8
Risk taking 1.1 1.6 3.0 -1.7 -0.6 -1.3 -1.3 -1.5 -0.1 -1.5
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.2 -0.4 -0.2 -0.5 0.1 -0.0 0.4
Fractured/broken bones in last 5 years 1.1 1.5 3.8 -0.0 0.7 -1.4 -1.4 -1.1 -0.8 -2.0
Age started oral contraceptive pill 1.1 1.3 3.8 -0.6 -1.1 1.1 1.4 0.5 0.5 2.0
Diastolic blood pressure, automated reading 0.3 0.9 5.1 2.3 -0.2 0.5 0.3 0.8 0.0 0.0
Ever depressed for a whole week 1.0 1.3 3.6 0.5 1.1 -0.9 -1.2 -0.0 -1.2 -1.9
Unable to work because of sickness or disability 0.8 1.0 1.7 0.7 -0.1 1.2 1.3 1.1 1.0 1.1
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.0 -0.4 0.4 0.4 -0.1 0.1 0.2
Myopia 1.0 1.4 3.6 0.0 -1.9 0.8 1.3 0.6 1.6 1.1
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.9 -0.5 -0.6 -0.7 -0.6 -1.0 0.1 -0.8
Cholesterol lowering medication 0.9 1.4 2.4 -0.4 -1.0 1.5 1.5 1.5 1.3 0.2
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.6 -0.2 -0.8 -0.1 -0.3 -0.1 0.2 -0.4
Pain experienced in last month 0.5 0.8 2.6 0.9 0.4 -0.6 -0.6 -1.1 -1.6 0.6
Supplements: Calcium 0.5 0.5 1.4 1.2 0.0 0.3 0.7 1.0 0.8 -0.2
Basal cell carcinoma (self-reported) 2.3 2.8 5.9 2.4 0.3 2.0 2.0 1.9 1.4 0.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.8 0.2 1.4 0.6 0.9 0.4 0.1 0.4
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.8 0.8 0.1 1.2 1.2 1.0 0.9 1.3
Heart disease (siblings) 1.3 1.5 3.6 -0.4 -1.9 1.3 1.1 1.0 1.7 0.6
Alcohol drinker status: Previous 0.4 0.4 0.8 -0.1 0.3 -0.9 -0.9 -0.6 -0.9 -0.4
Pack years of smoking 0.7 1.0 1.8 -0.2 0.3 -1.3 -0.7 -1.2 -1.2 -1.4
Impedance of whole body 0.8 3.8 11.2 -1.3 3.3 -1.6 -0.7 -1.3 -3.0 -0.6
Leg fat mass (left) 0.4 1.6 3.4 1.0 -1.6 1.1 1.0 1.2 1.8 -0.6
Arm predicted mass (left) 2.0 10.0 19.7 2.6 -3.1 3.8 3.1 3.0 4.4 1.1