Hub : Genes

ARHGAP9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.4270	0.0830	3.0e-09	0.380	NA	0.365	NA	0.371	6.5e-18	NA	4.1e-17	NA	2.1e-17
2	GTEx	Whole Blood	0.0530	0.0260	4.6e-03	0.048	NA	-0.002	NA	0.022	3.1e-05	NA	6.8e-01	NA	3.5e-03
3	METSIM	Adipose	0.0517	0.0276	7.3e-03	0.016	0.006	0.000	0.006	0.006	1.8e-03	3.4e-02	2.8e-01	3.5e-02	4.3e-02
4	YFS	Blood	0.3164	0.0466	0.0e+00	0.118	0.184	0.179	0.183	0.178	2.1e-36	6.8e-58	2.7e-56	1.9e-57	6.5e-56
5	TCGA	Stomach Adenocarcinoma	0.0670	0.0500	9.5e-03	0.001	0.014	0.026	NA	0.017	2.6e-01	3.1e-02	5.4e-03	NA	1.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	2.0	3.2	6.1	2.5	-1.3	-1.4	-1.0	2.3
Bipolar Disorder or Schizophrenia	0.4	1.0	2.2	0.7	-0.7	-1.0	-0.9	1.5
Depressed Affect (Nagel 2018)	0.6	1.3	2.8	0.7	0.8	1.7	1.1	1.2
Depression (Nagel 2018)	0.7	1.0	2.3	-1.5	1.3	1.0	0.1	-0.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.0	0.1	-1.0	-0.3	-0.5	-0.7
Neuroticism (Nagel 2018)	0.2	0.5	1.7	-0.3	0.3	0.9	1.3	-0.2
Schizophrenia (2018)	0.1	0.3	1.2	-1.1	0.1	-0.2	-0.3	0.0
Schizophrenia vs Biploar Disorder	1.6	2.1	5.9	-2.4	1.2	0.7	1.6	-0.4
Worry (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.0	-0.1	0.6	-0.9
Alzheimer’s Disease (in mother)	0.7	0.8	1.9	-1.4	0.5	-0.3	-1.2	-0.6
Alzheimer’s Disease (in father)	0.8	0.9	1.7	1.3	-1.3	-0.9	0.3	0.1
Alzheimer’s Disease (including proxy)	0.7	1.0	1.5	-0.9	-0.7	-1.1	-1.0	-1.2
Crohns Disease (2017)	0.1	0.3	1.0	-0.3	-0.0	1.0	0.5	0.1
Irritable Bowel Disease (IBD)	1.7	4.1	8.4	-2.9	2.1	2.5	1.0	-0.4
Ulcerative Colitis (UC)	2.0	3.8	8.3	-2.9	2.5	2.0	0.5	-0.6
Major Depression (MDD)	0.8	0.9	2.5	0.1	-1.3	-1.6	0.4	0.7
Reaction Time	1.2	2.4	7.7	-0.0	-1.8	-2.8	-1.0	-0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.3	-1.1	0.1	0.8	-0.1	-1.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.8	1.1	2.2	1.3	-0.8	-1.5	-0.6	0.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.3	2.7	1.1	-1.6	-1.1	-1.1	-0.1
Bipolar Disorder (2011)	1.5	1.4	5.7	2.4	-0.4	-0.3	1.1	0.0
Body Mass Index (BMI) (2010)	1.1	1.6	5.1	-2.2	0.8	1.0	0.8	-0.8
Coronary Artery Disease (CAD)	0.2	0.3	0.8	-0.7	0.9	0.3	0.2	0.0
Crohns Disease (2012)	0.2	0.4	1.1	-1.0	-0.4	0.4	0.4	-0.5
Mean Putamen Volume	2.0	2.3	4.1	-0.4	-1.7	-0.9	-1.8	-2.0
Fasting Glucose	0.3	0.3	0.8	0.3	-0.9	-0.5	0.6	-0.5
HbA1C	0.2	0.2	0.9	0.1	-0.0	0.0	1.0	0.4
HDL Cholesterol	1.3	2.2	6.8	-2.6	-0.1	-0.1	-0.1	-2.1
LDL Cholesterol	1.2	1.8	5.5	1.1	1.0	0.8	0.9	2.4
Lupus	0.2	0.4	1.8	0.1	0.1	0.0	1.3	-0.0
Neuroticism (2016)	0.7	1.1	3.8	2.0	-1.0	0.5	-0.4	0.3
Primary Biliary Cirrhosis	0.6	0.8	2.5	-0.7	-1.6	-0.3	-0.1	-0.9
Rheumatoid Arthritis	1.8	2.5	5.1	-1.9	2.3	1.3	1.5	0.1
Schizophrenia (2014)	0.3	0.6	1.6	0.3	-0.5	-0.9	0.4	1.3
Triglycerides	0.6	1.0	2.7	1.6	-0.4	-0.6	0.8	1.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.5	1.1	-1.6	-0.8	-0.3	0.4
Ulcerative Colitis	2.8	4.1	12.5	-3.5	2.0	1.2	0.9	-1.4
Blood Eosinophil Count	0.1	0.5	1.0	-0.5	1.0	0.8	0.3	0.6
Blood Platelet Count	2.3	26.3	86.9	9.3	-1.2	-4.1	-2.8	4.3
Blood Red Count	0.2	1.6	6.2	-2.5	0.5	0.1	-0.2	-1.3
Blood White Count	0.5	3.6	5.2	0.5	2.0	2.2	2.3	2.0
Heel T-Score	0.1	0.6	1.2	1.1	-0.0	-0.8	-1.1	0.4
BMI	0.7	3.9	8.3	2.9	-1.7	-2.3	-1.4	1.0
Height	0.8	16.0	35.9	-3.1	-5.8	-0.8	-0.3	-6.0
Waist Hip Ratio (WHR)	0.3	1.5	4.9	1.5	-2.2	0.3	-0.4	-0.0
Systolic Blood Pressure	1.1	5.4	14.7	1.4	-2.5	-3.8	-1.3	-1.5
Smoking Status	0.1	0.2	0.5	0.5	-0.2	0.5	0.7	0.5
Allergy or Eczema	1.0	2.5	6.5	-1.0	2.5	1.9	1.0	0.7
Cardiovascular Disease	1.3	4.4	7.4	2.7	-2.4	-2.3	-1.8	-0.4
Hypothyroidism (self reported)	1.2	2.7	10.0	-3.2	1.0	0.6	0.0	-1.4
Respiratory disease	1.7	3.7	7.8	-2.8	2.4	1.1	2.0	0.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.3	1.2	-1.8	-1.1	0.8	-0.2
Lung FEV1/FVC ratio	0.3	1.7	4.2	1.0	0.4	-1.6	-0.7	2.0
Lung FVC	0.3	1.4	3.5	1.9	-1.7	0.3	-0.5	0.5
Neuroticism	0.3	0.7	1.6	0.4	-0.1	1.2	1.2	0.5
Chronotype (morning person)	0.8	1.8	4.5	2.1	1.1	1.3	1.0	0.9
Hair Pigment	0.1	3.6	8.0	-1.2	-1.5	-2.8	-1.7	-1.8
Tanning	0.0	0.0	0.0	0.2	-0.0	-0.2	0.2	-0.1
Hand grip strength (left)	0.4	1.0	2.1	-0.6	-1.5	-0.5	0.6	-1.5
Number of treatments/medications taken	0.4	0.8	1.9	0.9	-1.4	-0.3	-1.0	-0.4
Average weekly spirits intake	0.7	0.9	1.9	0.6	-1.1	-0.8	-1.4	-0.8
Sensitivity / hurt feelings	0.2	0.3	1.2	0.2	-0.0	0.5	1.1	-0.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.8	-1.0	1.3	0.9	0.5	0.4
Hearing difficulty/problems: Yes	0.4	0.6	1.6	-1.3	0.9	0.3	0.5	-0.3
Relative age of first facial hair	1.4	3.0	5.4	1.9	1.2	1.6	1.3	2.3
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.9	-1.1	1.7	1.2	-0.3	0.9
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.4	-0.7	-0.9	0.0	-1.1	-1.9
Ever had hysterectomy (womb removed)	0.6	0.6	2.2	0.2	-0.6	-0.6	-1.5	-0.3
Systolic blood pressure, automated reading	1.1	3.1	8.4	-0.1	-1.8	-2.9	-0.2	-2.0
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	3.6	1.1	-1.4	-1.9	-1.6	0.0
Angina	1.4	1.8	4.7	2.2	0.7	-0.5	-0.2	1.9
Medication for hormone replacement therapy	0.2	0.2	0.7	0.2	-0.4	-0.2	-0.8	-0.5
Vitamin and mineral supplements	1.4	1.8	7.0	-2.6	1.0	-0.2	0.5	-1.0
Supplements: Zinc	1.2	1.3	3.1	1.8	0.8	0.7	0.6	1.4
Medication: Co-codamol	0.1	0.1	0.4	-0.1	0.1	-0.4	-0.6	0.3
Medication: Metformin	0.7	1.0	1.8	1.0	-1.4	-1.1	-1.0	-0.4
Diabetes (father)	0.3	0.4	0.8	-0.9	-0.1	0.2	-0.2	-0.9
Diabetes (mother)	0.2	0.3	0.6	-0.6	-0.4	-0.5	-0.5	-0.8
Severe depression (siblings)	2.0	2.3	7.0	-2.7	1.4	1.3	0.8	0.0
Pack years adult smoking proportion	0.1	0.2	0.8	0.2	0.3	0.1	-0.3	0.9
Impedance of leg (right)	0.5	2.2	4.7	-2.2	0.5	1.5	1.2	-1.5
Leg fat-free mass (left)	0.9	4.8	11.6	0.9	-3.4	-2.7	-1.4	-1.5
Trunk fat percentage	1.5	6.1	15.6	0.4	-4.0	-2.3	-1.6	-2.7
Hand grip strength (right)	0.4	1.1	3.4	0.2	-1.8	-0.3	0.3	-1.5
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.7	-0.0	-0.0	-0.9	-0.3
Current tobacco smoking	0.9	1.4	3.2	0.2	1.4	1.8	0.8	1.1
Average weekly fortified wine intake	1.9	2.2	5.2	-0.7	2.3	2.0	0.6	1.0
Maternal smoking around birth	0.1	0.1	0.3	-0.2	0.2	0.3	0.2	0.5
Fed-up feelings	1.1	2.1	5.0	-0.4	1.5	2.2	1.4	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-0.6	1.0	0.7	-0.0	0.3
Relative age voice broke	0.3	0.5	2.0	-0.6	-0.3	0.1	0.0	-1.4
Taking other prescription medications	0.2	0.3	0.9	-0.1	0.8	0.4	-0.0	0.9
Age when periods started (menarche)	0.8	2.0	4.6	-2.1	0.9	1.1	-0.9	-1.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	0.9	0.5	0.6	-0.5	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-0.1	-0.1	-0.8	-1.0	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.4	0.2	0.5	-0.3	0.0
Qualifications: CSEs or equivalent	0.2	0.2	0.8	-0.0	0.2	0.5	0.9	-0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.7	0.5	-0.2	0.3	0.4
High blood pressure	1.3	3.6	6.2	1.7	-2.5	-1.6	-2.4	-0.8
Hayfever, allergic rhinitis or eczema	2.6	5.7	14.2	-2.3	3.8	2.6	1.3	0.8
Multivitamins +/- minerals	0.9	1.2	3.6	1.9	-1.1	-0.4	-0.9	0.5
Stomach or abdominal pain in last month	0.3	0.4	0.7	0.3	0.7	-0.7	-0.8	-0.2
Supplements: Glucosamine	0.9	1.1	2.5	0.3	0.8	1.6	1.5	0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.7	1.3	0.8	-1.2	-0.4	-1.1	-0.1
Medication: Atenolol	1.2	1.6	4.5	2.1	-0.2	0.1	-0.9	1.6
Medication: Levothyroxine sodium	2.1	3.5	10.7	-3.3	0.2	0.3	-0.6	-2.5
Sitting height	1.6	11.3	23.3	-3.0	-4.2	-2.2	-1.1	-4.8
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	0.1	0.7	1.3	0.3	0.4
High blood pressure (mother)	3.3	4.6	8.0	0.3	-2.8	-2.4	-1.2	-2.7
Body mass index (BMI)	1.0	4.3	8.1	2.8	-2.1	-2.7	-1.3	0.4
Impedance of leg (left)	0.5	2.4	5.7	-2.4	0.7	1.6	0.9	-1.5
Leg predicted mass (left)	0.9	4.6	11.2	0.9	-3.3	-2.6	-1.4	-1.4
Trunk fat mass	1.6	7.0	17.6	0.5	-4.2	-2.6	-1.7	-2.7
Waist circumference	1.5	5.6	12.6	2.4	-3.5	-2.5	-1.7	-0.5
Number of incorrect matches in round	0.2	0.4	1.9	-1.4	-0.0	-0.2	0.0	0.2
Past tobacco smoking	0.8	1.4	2.2	-1.5	1.4	1.4	0.9	-0.4
Alcohol usually taken with meals	0.1	0.2	0.4	0.5	0.3	0.6	0.5	-0.0
Nervous feelings	0.2	0.3	1.0	-0.2	-0.3	-0.7	-1.0	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.7	-0.7	0.4	1.3	0.2	-0.2
Hearing difficulty/problems with background noise	0.5	0.9	1.8	-1.1	1.4	0.8	0.8	-0.0
Hair/balding pattern: Pattern 2	1.5	1.9	3.4	1.8	-1.9	-1.6	-0.1	-0.6
Had menopause	0.6	0.8	1.4	-1.1	0.3	1.2	1.0	-0.1
Had other major operations	0.7	0.8	2.3	0.9	-0.1	-0.9	-1.5	0.3
Forced vital capacity (FVC)	0.9	3.3	11.0	-0.0	-3.3	-0.9	-1.0	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.5	0.4	0.5	-0.6	-1.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	0.4	-0.2	-1.0	-0.8	-0.3
Qualifications: None of the above	0.4	0.8	1.3	0.6	-0.7	-1.1	-1.0	0.8
Financial difficulties in last 2 years	0.4	0.5	1.2	0.9	0.5	-0.5	-0.3	1.1
Mouth/teeth dental problems	1.8	2.7	5.2	-2.3	2.3	0.8	1.2	-0.9
Heart attack	1.6	2.0	7.2	2.7	-0.2	-0.8	-0.1	1.4
Allergy	2.0	4.5	10.5	2.4	-3.2	-1.8	-1.7	-0.5
Pain all over the body in last month	1.2	1.3	2.4	-1.6	1.5	1.3	0.2	0.4
Diabetes (self-reported)	0.5	0.8	1.6	0.1	-1.3	-1.0	0.1	-1.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.6	-1.5	1.6	1.0	0.6	0.1
Medication: Ramipril	0.4	0.5	2.4	-0.2	-0.5	0.0	-1.6	0.1
Medication: Simvastatin	1.9	2.8	4.7	1.9	-1.8	-2.2	-1.6	0.2
Fluid intelligence score	0.5	1.1	2.6	-1.6	0.5	1.1	0.0	-1.2
Illnesses of siblings	1.9	2.7	4.5	0.5	2.0	1.9	1.0	2.1
Neuroticism score	0.3	0.6	1.8	0.2	0.3	1.3	0.8	0.8
Weight	1.2	5.7	13.9	1.3	-3.7	-2.9	-1.5	-1.6
Impedance of arm (right)	1.4	6.7	17.5	-4.2	-1.0	1.3	0.7	-3.6
Arm fat percentage (right)	1.2	4.6	10.3	1.9	-3.2	-2.5	-1.4	-1.0
Trunk fat-free mass	0.4	2.3	5.9	0.8	-2.4	-1.9	-0.9	-0.7
Hip circumference	1.0	4.3	8.7	0.8	-3.0	-2.7	-1.6	-1.5
Time employed in main current job	0.2	0.2	0.4	-0.4	-0.1	-0.5	-0.7	0.3
Alcohol intake versus 10 years previously	2.6	3.8	12.4	3.5	-0.4	-0.4	-0.0	2.5
Father’s age at death	0.9	1.2	3.5	-1.1	0.6	1.9	1.0	0.2
Worrier / anxious feelings	0.4	0.8	1.7	-0.4	-0.8	1.2	0.5	-1.3
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	4.0	-1.8	2.0	1.8	1.5	0.3
Falls in the last year	0.1	0.1	0.3	-0.4	0.1	0.2	-0.2	-0.6
Hair/balding pattern: Pattern 3	0.7	1.0	2.2	-1.5	-0.1	0.6	0.8	-1.4
Number of live births	0.1	0.1	0.2	-0.1	-0.5	-0.3	-0.1	0.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	8.7	0.3	-3.0	-1.3	-1.0	-1.5
Pulse rate	0.1	0.2	0.8	0.5	0.1	-0.2	-0.2	0.9
Happiness	0.9	1.0	2.1	-1.2	1.4	0.6	-1.2	0.0
Noisy workplace	0.2	0.2	0.4	0.2	0.0	-0.6	-0.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	-0.4	-0.5	-0.0	0.5	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.2	-0.1	-0.2	0.2	0.0
Mouth/teeth dental problems: Dentures	0.4	0.7	1.6	1.3	-0.9	-0.5	-0.7	0.6
Asthma	2.3	4.6	9.9	-2.9	3.1	1.0	1.7	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.0	1.5	-2.0	-1.0	-0.8	-1.1
Medication: Cholesterol lowering	0.9	1.3	2.7	1.6	-0.8	-1.6	-0.9	0.0
Depression (self-reported)	1.0	1.3	3.6	-1.9	0.8	0.9	-0.2	-1.1
Medication: Lansoprazole	0.4	0.5	1.2	-1.1	0.5	0.9	0.3	0.1
Prospective memory result	0.6	0.7	2.4	0.4	0.9	-0.6	-0.1	1.5
Lung cancer (father)	0.4	0.5	1.3	-0.1	-1.2	-0.7	-0.7	-0.5
Illnesses of mother	1.0	1.2	2.7	-0.6	1.4	1.7	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	5.7	1.2	-2.4	-1.2	-0.4	-0.3
Pulse wave Arterial Stiffness index	0.4	0.4	1.3	-0.1	-1.1	-0.7	-0.1	-0.6
Impedance of arm (left)	1.1	5.3	12.2	-3.5	-0.9	1.8	1.3	-2.9
Arm fat mass (right)	1.3	5.5	12.5	1.8	-3.5	-2.8	-1.4	-1.4
Trunk predicted mass	0.4	2.2	5.5	0.9	-2.4	-1.9	-0.9	-0.6
Standing height	1.0	9.6	20.2	-2.9	-4.2	-1.0	-0.7	-4.5
Length of working week for main job	0.2	0.3	0.6	0.6	-0.3	0.3	0.4	-0.8
Exposure to tobacco smoke at home	1.8	2.0	6.1	1.3	-1.4	-2.5	-0.5	-0.1
Breastfed as a baby	0.3	0.3	1.0	0.4	-0.6	0.0	1.0	0.3
Tense / ‘highly strung’	0.1	0.1	0.3	-0.5	-0.5	-0.4	0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.8	-0.6	-0.1	-0.7	-0.5	-0.9
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	1.5	-0.3	-0.1	-1.0	0.9
Birth weight of first child	0.4	0.8	1.3	-0.3	-1.1	-0.9	-0.9	-1.1
Peak expiratory flow (PEF)	1.2	2.7	5.7	-0.9	-1.7	-1.4	-1.5	-2.4
Pulse wave reflection index	0.5	0.6	1.4	-0.5	-0.6	-0.2	-0.9	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.8	-0.8	-0.2	-0.3	0.4	-0.9
Loud music exposure frequency	1.1	1.2	2.7	-0.7	1.6	1.5	0.6	0.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	2.9	1.6	0.8	0.5	1.7	1.5
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.2	1.8	-1.7	-0.2	-0.2	0.7
Blood clot in the leg (DVT)	0.5	0.7	1.2	1.1	-1.0	-1.0	-0.2	0.2
Medication: Paracetamol	0.3	0.5	2.1	0.1	0.4	1.4	0.5	-0.4
Headache pain in last month	1.0	1.7	4.9	0.8	1.4	2.2	-0.6	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	2.8	-0.3	0.9	1.1	1.7	0.4
Glaucoma (self-reported)	0.3	0.4	1.1	-0.8	0.1	-0.1	-0.3	-1.0
Gout (self-reported)	2.8	3.9	6.1	2.2	-2.5	-2.0	-0.8	-2.0
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	7.7	-2.8	1.0	0.5	-0.1	-1.4
Medication: Amlodipine	0.0	0.1	0.2	-0.1	-0.1	-0.4	0.2	0.2
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.6	-1.4	1.9	-0.4	0.2	0.3
Birth weight	0.6	1.3	4.5	-0.1	-2.1	-0.8	-0.9	-0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	-0.7	0.5	1.2	0.9	0.5
High blood pressure (siblings)	3.5	5.1	10.4	-0.2	-3.2	-2.6	-0.9	-2.7
Forced vital capacity (FVC), Best measure	0.6	2.2	8.6	0.8	-2.9	-0.8	-0.2	-1.0
Body fat percentage	1.2	4.9	12.4	1.3	-3.5	-2.4	-1.4	-1.7
Leg fat percentage (right)	0.7	2.6	4.3	2.1	-1.9	-2.1	-1.0	0.1
Arm fat-free mass (right)	0.6	3.1	5.9	1.7	-2.4	-2.3	-1.2	-0.3
Exposure to tobacco smoke outside home	2.3	3.1	5.9	2.4	-1.0	-2.1	-1.8	0.8
Comparative body size at age 10	0.1	0.3	1.2	0.1	0.3	0.4	0.1	1.1
Number of full brothers	1.9	2.4	3.3	-0.8	-1.3	-1.7	-1.8	-1.8
Worry too long after embarrassment	0.6	1.0	3.0	-1.1	-0.7	-0.3	-0.4	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	-1.1	1.2	0.3	0.0	-0.2
Wheeze or whistling in the chest in last year	0.3	0.6	1.0	1.0	0.6	-0.6	-0.5	1.0
Number of children fathered	0.2	0.2	0.4	0.2	-0.0	0.7	0.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	-0.4	-1.0	-0.2	0.8	0.4
Age at first live birth	0.2	0.4	0.6	-0.5	-0.7	-0.8	-0.3	-0.7
Pulse wave peak to peak time	0.2	0.2	0.6	-0.0	0.8	0.6	-0.0	0.3
Health satisfaction	0.6	0.7	1.8	-0.4	-0.5	-1.4	-0.4	-1.1
Shortness of breath walking on level ground	0.3	0.4	1.6	-1.3	0.4	0.3	0.1	-0.3
Qualifications: College or University degree	0.4	1.2	4.0	-2.0	0.3	0.3	-0.2	-1.4
Eye problems/disorders: None of the above	2.4	2.8	5.5	1.1	1.3	1.5	1.9	2.4
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.4	0.0	-1.8	-1.2	-1.7	-1.8
Emphysema/chronic bronchitis	0.1	0.2	0.3	-0.6	0.4	-0.2	-0.3	-0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	2.6	-1.6	1.0	0.0	0.3	0.7
Neck or shoulder pain in last month	0.4	0.6	0.9	1.0	0.7	0.9	-0.1	0.9
Medication: Blood pressure	0.9	1.6	4.8	-0.3	-1.2	-0.8	-2.2	-0.9
Angina (self-reported)	1.2	1.6	4.3	2.1	0.6	-0.5	-0.3	1.8
Migraine (self-reported)	1.9	2.3	7.4	0.2	1.8	2.7	-0.4	1.0
Medication: Ibuprofen	0.8	1.0	2.2	0.7	-1.5	-0.6	-0.5	-1.3
Medication: Allopurinol	3.2	4.3	10.7	3.3	-2.5	-2.2	-0.1	0.0
Medication: Omeprazole	0.7	0.9	2.2	-1.2	-0.6	-0.1	0.7	-1.5
Medication: Seretide 50 evohaler	4.7	5.4	13.5	-3.7	2.4	1.3	1.6	-1.9
Mean time to correctly identify matches	1.0	1.9	4.4	-0.4	-1.6	-2.1	-1.4	-0.7
Heart disease (mother)	1.9	2.3	5.3	0.6	-2.1	-2.3	-0.5	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.3	1.8	0.8	0.0	-0.2	1.8
Whole body fat mass	1.4	6.0	15.1	1.2	-3.9	-2.7	-1.6	-2.0
Leg fat mass (right)	1.0	4.0	8.1	2.0	-2.8	-2.4	-1.2	-0.5
Arm predicted mass (right)	0.6	3.2	6.1	1.5	-2.5	-2.4	-1.3	-0.5
Pulse rate, automated reading	0.6	2.1	4.7	0.9	-1.8	-2.2	-1.3	-0.2
Alcohol intake frequency.	0.6	1.4	3.7	1.9	-0.1	0.5	-0.3	1.7
Comparative height size at age 10	1.0	5.3	12.1	-2.9	-2.4	0.6	0.0	-3.5
Number of full sisters	0.7	0.9	2.9	0.2	0.5	0.5	1.7	1.0
Suffer from ‘nerves’	0.4	0.6	1.7	-0.9	1.3	0.5	0.2	0.6
Overall health rating	0.2	0.4	1.2	-1.1	0.2	-0.4	-0.5	-0.4
Chest pain or discomfort	1.2	1.8	3.8	0.7	1.4	1.9	0.1	1.6
Had major operations	0.2	0.3	1.0	-1.0	-0.2	0.1	0.1	-0.6
Age at last live birth	0.5	0.8	2.6	0.5	-0.7	-1.6	-0.7	-0.0
Family relationship satisfaction	0.5	0.6	1.6	-0.2	1.0	0.3	1.2	0.4
Leg pain on walking	0.6	0.8	2.8	-1.0	-0.1	0.1	1.7	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.5	0.2	0.4	0.1	-0.2
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.6	1.0	-1.6	-1.0	0.2	-1.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	-0.7	-0.8	-0.3	-0.5	-1.0
Medication: Aspirin	0.4	0.6	1.5	1.2	-0.7	-0.8	-0.5	0.2
Supplements: Vitamin C	0.4	0.5	1.2	0.9	-0.6	-0.0	1.1	0.0
Knee pain experienced in last month	0.6	0.9	1.9	-0.7	1.4	1.2	0.5	-0.5
Hypertension (Self-reported)	1.9	5.2	9.8	1.8	-3.1	-2.1	-2.7	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	-0.3	-0.8	0.1	-0.6	-1.1
Illnesses of father: Heart disease	0.9	1.3	3.5	1.9	-1.3	-0.8	-0.5	-0.5
Illnesses of siblings: Diabetes	0.7	0.9	2.0	-0.9	-1.0	-0.8	-0.3	-1.4
Smoking status: Previous	1.0	1.4	2.8	1.2	-1.7	-1.7	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.7	-0.4	-0.1	-0.2	-0.8	-0.8
Whole body fat-free mass	0.6	3.3	7.8	0.9	-2.8	-2.3	-1.2	-1.0
Leg fat-free mass (right)	0.8	4.4	10.3	0.8	-3.2	-2.6	-1.5	-1.4
Arm fat percentage (left)	1.0	4.2	9.5	2.1	-3.1	-2.2	-1.1	-0.7
Average weekly red wine intake	0.4	0.5	1.5	-1.2	0.8	-0.2	-0.6	-0.3
Handedness (chirality/laterality): Left-handed	4.0	4.8	14.7	-3.8	1.3	1.5	-0.2	-2.3
Mood swings	0.7	1.3	3.6	1.4	0.6	0.7	0.5	1.9
Loneliness, isolation	0.2	0.3	0.8	0.9	0.3	0.2	-0.5	0.5
Long-standing illness, disability or infirmity	1.2	1.9	6.8	-2.6	1.0	0.5	-0.1	-1.2
Ever had bowel cancer screening	0.3	0.4	1.5	0.5	-0.3	1.2	0.0	0.0
Diabetes diagnosed by doctor	0.9	1.4	3.2	1.0	-1.8	-1.5	-0.6	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	5.5	-2.3	2.2	2.3	0.7	0.4
Friendships satisfaction	0.9	1.1	2.7	-1.0	1.1	0.6	1.6	0.5
Qualifications: nursing, teaching	0.7	1.1	3.7	0.8	-1.9	-0.9	-0.5	-0.2
Commuting to job workplace: Walk	0.9	1.0	2.7	1.3	-0.3	-0.4	0.6	1.6
Eye problems/disorders: Cataract	1.5	1.7	3.4	-0.5	-1.7	-0.2	-1.9	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	4.7	1.1	-2.2	-1.0	-0.8	-0.2
Medication for cholesterol	1.9	2.9	6.3	-1.9	2.5	1.6	1.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.1	0.2	-0.2	-0.2	-1.1	-0.3
Back pain experienced in last month	0.8	1.1	3.3	-0.3	-0.0	-0.2	-1.8	-1.5
Mineral and other dietary supplements	0.5	0.7	2.8	-1.7	0.7	-0.0	-0.4	-0.3
Breast cancer (self-reported)	0.6	0.7	0.9	-0.8	0.9	1.0	-0.4	0.8
Asthma (self-reported)	2.3	4.5	10.1	-2.9	3.2	0.9	1.7	0.7
Osteoporosis (self-reported)	0.7	0.9	2.0	-0.8	1.4	1.3	0.0	0.5
Osteoarthritis (self-reported)	0.3	0.4	1.1	-1.0	-0.1	0.6	0.3	-0.6
Medication: Aspirin	0.2	0.3	0.5	0.6	-0.7	-0.6	-0.4	-0.3
Medication: Gliclazide	1.5	1.7	3.7	1.9	-1.6	-1.4	-0.7	0.1
Illnesses of father: None of the above (group 1)	3.4	4.2	10.4	-1.2	3.2	1.6	0.8	2.4
Smoking status: Current	0.8	1.3	2.6	0.3	1.4	1.6	0.6	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.7	1.6	-0.5	-0.2	-0.2	1.4
Whole body water mass	0.6	3.4	8.2	1.2	-2.9	-2.4	-1.2	-0.8
Leg predicted mass (right)	0.9	4.6	10.7	0.9	-3.3	-2.7	-1.6	-1.4
Arm fat mass (left)	1.3	5.5	12.5	2.2	-3.5	-2.7	-1.3	-1.0
Number of self-reported non-cancer illnesses	0.3	0.5	1.4	-1.2	0.5	0.9	-0.1	-0.3
Average weekly champagne plus white wine intake	0.8	1.1	2.8	-1.7	1.1	0.9	0.9	-0.2
Miserableness	0.6	1.1	2.6	0.1	0.7	1.3	1.6	0.8
Guilty feelings	0.4	0.7	1.7	-0.5	0.3	1.1	1.3	0.1
Wears glasses or contact lenses	0.5	0.6	1.2	-0.5	0.3	1.1	0.8	0.8
Ever taken oral contraceptive pill	0.6	0.7	1.6	-1.1	0.3	-0.4	-0.5	-1.3
Hearing aid user	0.5	0.5	1.2	-1.1	0.5	0.5	0.8	0.4
Mother’s age at death	0.8	1.0	2.5	1.6	0.6	0.7	0.1	1.4
Financial situation satisfaction	0.4	0.5	1.6	-0.5	1.3	-0.5	0.3	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.8	0.3	0.1	-0.5	0.9	0.1
Commuting to job workplace: Public transport	0.8	0.9	3.1	-1.8	0.7	1.0	-0.0	-0.2
Eye problems/disorders: Glaucoma	0.6	0.7	2.5	-0.4	-0.2	-0.6	-0.8	-1.6
Medication: Blood pressure	1.3	2.5	5.9	1.9	-2.4	-1.4	-1.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.6	-0.1	0.8	0.8	1.3	0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.1	1.8	-1.1	-0.8	-0.5	-0.1
High cholesterol (Self-reported)	1.7	3.1	4.3	2.1	-1.9	-2.0	-1.8	-0.4
Medication: Bendroflumethiazide	1.1	1.7	3.2	-0.2	-1.6	-1.0	-1.8	-1.2
Medication: Paracetamol	0.6	0.9	3.7	0.1	0.7	1.9	0.7	-0.1
Medication: Lisinopril	1.7	2.2	3.4	1.5	-1.8	-1.4	-1.8	-0.4
Medication: Atorvastatin	0.2	0.2	0.4	0.4	0.4	-0.0	-0.6	-0.6
Illnesses of father: High blood pressure	2.6	3.2	7.2	0.3	-2.7	-1.1	-1.6	-2.2
Alcohol drinker status: Never	0.4	0.4	1.0	-0.4	0.2	1.0	0.3	1.0
Ever smoked	0.5	0.8	2.1	1.0	-0.7	-0.7	-1.4	0.1
Basal metabolic rate	0.8	4.2	9.9	1.1	-3.1	-2.6	-1.3	-1.1
Leg fat percentage (left)	0.8	2.7	4.7	2.0	-1.9	-2.2	-1.2	0.0
Arm fat-free mass (left)	0.7	3.8	7.5	1.2	-2.7	-2.7	-1.4	-0.8
Number of operations (self-reported)	0.1	0.1	0.3	-0.5	0.2	0.4	-0.4	0.1
Average weekly beer plus cider intake	0.3	0.5	0.8	0.9	-0.9	-0.7	0.2	-0.4
Irritability	1.7	2.9	7.7	2.2	0.2	0.3	1.4	2.8
Risk taking	2.0	3.0	7.6	2.8	-1.7	-1.9	-0.7	0.8
Ever had prostate specific antigen (PSA) test	2.5	2.8	5.4	-2.3	2.1	1.9	0.4	-0.7
Fractured/broken bones in last 5 years	0.5	0.7	2.0	-1.4	-0.5	-0.0	0.3	-1.1
Age started oral contraceptive pill	1.5	1.9	4.3	0.5	-2.1	-1.5	-1.2	-1.0
Diastolic blood pressure, automated reading	0.8	2.6	6.8	-0.5	-0.9	-2.6	0.8	-2.1
Ever depressed for a whole week	0.2	0.2	0.4	0.6	-0.0	-0.3	-0.5	0.5
Unable to work because of sickness or disability	0.1	0.2	0.3	-0.6	-0.3	-0.5	0.0	-0.5
Commuting to job workplace: Cycle	0.7	0.9	2.4	1.6	-0.4	-1.1	-0.7	0.4
Myopia	2.2	3.2	7.0	-0.9	1.1	2.6	2.5	0.9
Vascular/heart problems diagnosed by doctor	1.4	3.9	6.2	-1.7	2.5	1.9	2.5	0.7
Cholesterol lowering medication	1.4	2.1	2.8	1.3	-1.6	-1.6	-1.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.4	-0.5	0.3	0.4	1.2	-0.4
Pain experienced in last month	0.6	1.0	3.3	-0.2	-0.4	-0.7	1.8	1.1
Supplements: Calcium	0.4	0.4	0.9	1.0	-0.9	0.3	-0.3	-0.2
Basal cell carcinoma (self-reported)	0.4	0.4	1.3	0.6	-1.1	0.3	0.5	0.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	6.0	2.5	-0.0	-0.8	0.0	1.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.2	1.1	-1.1	-0.8	-0.2	0.3
Heart disease (siblings)	0.2	0.3	0.9	0.5	-0.2	-1.0	-0.4	0.3
Alcohol drinker status: Previous	0.3	0.4	0.8	0.1	-0.9	-0.4	-0.9	-0.2
Pack years of smoking	0.1	0.1	0.3	0.1	-0.1	0.1	-0.6	0.5
Impedance of whole body	1.0	5.0	13.0	-3.6	-0.3	1.5	0.9	-3.0
Leg fat mass (left)	1.3	4.9	9.7	2.0	-3.1	-2.8	-1.6	-0.8
Arm predicted mass (left)	0.8	3.8	7.2	1.5	-2.7	-2.7	-1.5	-0.7