Hub : Genes

ARHGEF11

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.074	0.023	3.8e-05	0.048	0.046	0.032	0.045	0.046	1.4e-06	2.5e-06	7.0e-05	3.1e-06	2.4e-06
2	GTEx	Esophagus Mucosa	0.146	0.057	3.2e-03	0.035	NA	0.018	NA	0.024	2.1e-03	NA	2.0e-02	NA	8.8e-03
3	GTEx	Thyroid	0.357	0.045	0.0e+00	0.401	NA	0.444	NA	0.339	1.2e-32	NA	4.3e-37	NA	9.6e-27
4	TCGA	Stomach Adenocarcinoma	0.110	0.056	2.0e-03	0.014	0.043	0.034	NA	0.010	3.3e-02	4.5e-04	1.6e-03	NA	5.9e-02
5	TCGA	Thyroid Carcinoma	0.085	0.041	4.8e-04	0.064	0.041	0.035	NA	0.055	8.0e-07	6.3e-05	2.1e-04	NA	4.7e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.9	0.2	0.4	-0.2	0.9	0.4
Bipolar Disorder or Schizophrenia	0.3	0.7	2.5	1.6	-0.1	-0.6	0.2	0.8
Depressed Affect (Nagel 2018)	0.2	0.3	1.3	-0.0	0.3	-1.2	-0.1	0.5
Depression (Nagel 2018)	0.4	0.6	1.3	-0.8	-0.0	-1.1	1.2	-0.2
Intelligence (Savage-Jansen 2018)	1.4	4.2	9.6	-3.1	1.8	2.1	1.9	-0.0
Neuroticism (Nagel 2018)	0.3	0.7	1.9	1.0	0.2	-1.4	-0.6	0.5
Schizophrenia (2018)	0.5	0.9	3.6	1.9	-0.4	-0.6	-0.4	0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	1.0	-0.0	0.3	-1.2	0.2
Worry (Nagel 2018)	0.3	0.7	1.9	1.4	-0.0	-1.3	-0.3	0.1
Alzheimer’s Disease (in mother)	1.7	1.9	5.2	0.2	-1.1	-1.1	-2.3	-1.4
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.5	0.6	0.0	0.6	0.8
Alzheimer’s Disease (including proxy)	0.3	0.5	0.9	-0.6	-0.1	-0.4	-1.0	-0.9
Crohns Disease (2017)	1.8	4.1	8.0	2.0	-2.3	-2.8	-1.2	-1.2
Irritable Bowel Disease (IBD)	3.5	8.4	13.5	3.2	-3.1	-3.7	-2.4	-1.9
Ulcerative Colitis (UC)	2.8	5.2	7.1	2.7	-2.1	-2.6	-2.2	-1.6
Major Depression (MDD)	1.8	2.2	4.3	-0.2	-2.1	-1.9	0.7	-1.7
Reaction Time	1.8	3.5	9.2	2.0	-1.8	-3.0	-1.1	-0.4
Verbal and Numeric Reasoning (VNR)	2.1	5.0	14.1	-3.8	1.6	2.1	2.0	-0.0
Breast Cancer	1.3	3.1	6.4	0.4	-2.5	-1.6	-0.0	-2.5
Ovarian Cancer	0.1	0.2	0.7	0.8	0.2	-0.1	0.3	-0.2
Prostate Cancer	3.1	4.3	7.7	-2.4	1.1	2.1	2.8	1.6
Age at First Birth	1.5	2.2	5.0	-1.4	2.2	1.9	0.5	0.5
Bipolar Disorder (2011)	1.1	1.1	2.2	1.1	-1.2	-1.5	-0.2	-0.7
Body Mass Index (BMI) (2010)	0.8	1.1	2.8	-1.2	0.0	0.3	1.7	-0.9
Coronary Artery Disease (CAD)	2.5	3.0	5.5	2.3	-1.8	-1.8	-1.5	-0.8
Crohns Disease (2012)	1.7	2.7	5.8	0.8	-1.8	-2.4	-0.9	-1.7
Mean Putamen Volume	8.6	9.8	16.5	1.8	-4.1	-3.8	-3.0	-2.5
Fasting Glucose	1.5	1.8	2.6	-0.1	1.5	1.6	1.4	1.6
HbA1C	1.5	1.6	3.8	0.1	-1.5	-1.4	-0.4	-2.0
HDL Cholesterol	0.1	0.2	0.4	0.4	-0.0	-0.6	-0.7	0.2
LDL Cholesterol	0.3	0.4	0.7	-0.1	-0.8	-0.3	-0.8	-0.8
Lupus	1.2	1.8	3.4	0.1	1.5	1.2	1.2	1.9
Neuroticism (2016)	0.5	0.7	1.3	-0.1	1.1	0.6	1.1	0.9
Primary Biliary Cirrhosis	1.6	2.4	6.6	2.6	-0.3	-1.0	-1.5	1.4
Rheumatoid Arthritis	0.1	0.1	0.5	-0.0	0.7	0.2	0.3	0.4
Schizophrenia (2014)	0.3	0.7	1.5	0.8	0.6	0.5	0.9	1.2
Triglycerides	0.4	0.6	1.3	1.1	-0.7	-0.7	-0.7	-0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.7	-0.3	-0.3	0.5	0.3
Ulcerative Colitis	4.0	5.8	6.9	2.0	-2.3	-2.6	-2.5	-2.5
Blood Eosinophil Count	0.1	1.1	3.4	1.9	-0.0	-1.2	0.8	0.0
Blood Platelet Count	3.4	39.9	100.0	-9.1	0.8	2.6	10.0	-3.2
Blood Red Count	0.7	6.7	11.5	0.9	2.3	3.1	-2.5	3.4
Blood White Count	0.5	3.8	8.4	-1.0	1.6	1.4	2.9	2.3
Heel T-Score	1.8	14.2	27.4	2.9	-5.2	-3.9	-0.0	-4.5
BMI	0.2	1.4	3.4	-0.8	-1.2	-1.0	-0.6	-1.8
Height	0.3	4.9	19.4	-4.4	-0.3	-0.5	1.9	-1.0
Waist Hip Ratio (WHR)	0.4	1.9	4.8	1.1	-0.9	-2.2	-0.7	-1.4
Systolic Blood Pressure	0.7	3.6	9.1	1.5	1.6	1.9	-0.6	3.0
Smoking Status	0.9	2.1	3.5	-1.2	-1.6	-1.9	-0.9	-1.4
Allergy or Eczema	0.2	0.6	1.8	-1.0	0.7	0.1	0.1	-1.4
Cardiovascular Disease	1.5	5.0	14.3	2.7	-0.4	-0.2	-3.8	1.8
Hypothyroidism (self reported)	0.3	0.7	1.7	0.5	1.3	1.0	-0.1	0.8
Respiratory disease	0.4	0.8	1.8	-1.3	0.7	0.8	0.9	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.4	-0.7	-0.4	-0.3	-0.2
Lung FEV1/FVC ratio	0.2	0.8	3.1	-1.8	-0.7	-0.1	0.5	-0.5
Lung FVC	0.4	2.0	4.7	-1.0	1.4	1.3	0.7	2.2
Neuroticism	0.5	1.2	3.5	0.9	-0.4	-1.9	-1.1	-0.2
Chronotype (morning person)	3.2	7.4	13.1	2.4	-3.6	-3.1	-2.8	-0.7
Hair Pigment	0.2	4.9	8.6	2.2	-2.5	-2.9	-0.0	-2.2
Tanning	0.1	0.7	1.5	-1.2	-0.6	-0.2	0.4	-1.1
Hand grip strength (left)	1.2	3.0	5.3	-1.4	2.0	2.3	1.2	1.5
Number of treatments/medications taken	1.0	1.8	4.4	0.3	-1.1	-2.1	-0.4	-1.7
Average weekly spirits intake	2.2	2.7	6.2	1.3	-1.9	-1.2	-2.5	-0.8
Sensitivity / hurt feelings	0.4	0.7	1.8	0.9	-0.4	-0.9	-1.4	0.2
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.5	-0.5	-0.2	-1.2	0.8	0.3
Hearing difficulty/problems: Yes	4.3	6.6	12.4	1.4	-3.5	-3.5	-2.0	-1.7
Relative age of first facial hair	1.0	2.0	3.8	-2.0	1.8	1.3	1.0	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.7	-0.5	-0.2	0.3	-0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.0	0.2	0.1	0.5	0.3
Ever had hysterectomy (womb removed)	2.5	2.8	6.8	-0.9	1.8	2.6	0.5	1.8
Systolic blood pressure, automated reading	0.2	0.6	1.7	0.3	0.4	1.3	-0.1	1.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	4.4	0.1	-1.2	-1.5	0.0	-2.1
Angina	1.1	1.4	3.6	1.6	-0.3	-0.6	-1.9	0.9
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.1	-0.2	0.0	-0.4	-0.5
Vitamin and mineral supplements	0.4	0.6	1.4	0.5	0.5	1.2	-0.4	0.9
Supplements: Zinc	2.8	3.0	9.9	-3.1	1.2	1.3	1.5	0.2
Medication: Co-codamol	0.2	0.2	0.4	0.6	-0.6	-0.4	0.1	0.5
Medication: Metformin	0.7	1.0	2.3	0.5	-1.5	-0.7	-0.3	-1.3
Diabetes (father)	1.2	1.5	4.4	-0.5	-1.4	-0.9	0.5	-2.1
Diabetes (mother)	0.9	1.1	1.9	1.4	-1.1	-1.1	-0.2	-1.1
Severe depression (siblings)	2.9	3.3	8.9	-1.7	1.6	1.4	3.0	-0.2
Pack years adult smoking proportion	1.6	2.4	5.9	-1.3	1.3	0.8	2.4	1.5
Impedance of leg (right)	1.2	6.0	8.9	2.7	-3.0	-2.9	-1.1	-2.2
Leg fat-free mass (left)	0.3	1.5	7.1	-2.7	0.2	0.2	0.6	-0.0
Trunk fat percentage	1.8	7.3	13.5	0.2	-3.7	-3.2	-1.0	-3.4
Hand grip strength (right)	1.3	3.6	6.1	-0.9	2.2	2.2	1.2	2.5
Townsend deprivation index at recruitment	1.6	2.2	4.1	1.4	-2.0	-2.0	-0.6	-0.7
Current tobacco smoking	1.0	1.6	3.0	-0.7	-1.7	-1.7	0.2	-1.3
Average weekly fortified wine intake	0.4	0.4	1.1	-1.1	0.6	0.6	0.4	-0.4
Maternal smoking around birth	0.7	1.0	2.6	0.2	0.7	1.1	1.6	1.0
Fed-up feelings	0.2	0.3	0.9	0.7	0.1	-1.0	0.1	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	-0.9	0.1	-0.9	0.9	0.2
Relative age voice broke	0.1	0.1	0.3	-0.5	-0.3	-0.4	-0.2	-0.2
Taking other prescription medications	1.1	1.6	3.8	0.9	-1.1	-1.9	0.2	-1.5
Age when periods started (menarche)	0.1	0.1	0.4	0.2	-0.3	0.1	0.7	0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.3	0.4	0.5	0.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	3.4	1.8	-1.5	-1.8	-0.4	-1.8
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.5	0.3	-1.1	-2.1	-1.2	-1.3
Qualifications: CSEs or equivalent	0.7	1.0	2.0	0.9	0.8	0.8	0.9	1.4
Serious illness, injury or assault to yourself	0.5	0.6	2.2	1.5	-0.6	-0.7	-0.3	0.1
High blood pressure	1.2	3.3	8.3	2.4	-0.4	-0.4	-2.9	1.4
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.1	-1.5	2.0	1.4	1.4	-0.5
Multivitamins +/- minerals	0.7	0.9	2.4	0.5	-0.8	-1.5	0.5	-1.0
Stomach or abdominal pain in last month	0.4	0.5	1.3	-0.9	-0.1	-0.2	1.1	-0.6
Supplements: Glucosamine	0.3	0.4	1.3	0.1	0.3	-1.1	0.4	-0.7
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	3.3	-1.3	1.6	1.8	0.9	1.5
Medication: Atenolol	0.7	0.8	2.6	1.6	0.4	-0.6	-0.6	0.8
Medication: Levothyroxine sodium	0.4	0.7	1.9	-0.1	1.4	1.0	0.2	0.6
Sitting height	0.6	4.3	9.0	-3.0	1.5	2.0	1.5	2.1
Chronic bronchitis/emphysema (father)	0.9	1.0	2.7	1.0	-0.4	-1.6	-0.7	-1.0
High blood pressure (mother)	1.5	2.1	6.1	2.5	0.7	-0.2	-1.7	1.0
Body mass index (BMI)	0.4	1.7	3.3	-0.6	-1.5	-1.2	-1.0	-1.8
Impedance of leg (left)	1.1	5.3	8.3	2.0	-2.9	-2.6	-1.0	-2.5
Leg predicted mass (left)	0.3	1.5	7.0	-2.6	0.2	0.2	0.6	-0.0
Trunk fat mass	1.4	5.8	10.9	-0.4	-3.3	-2.8	-0.9	-3.1
Waist circumference	0.9	3.3	5.1	-0.3	-2.3	-2.2	-1.5	-2.1
Number of incorrect matches in round	1.2	2.1	5.6	2.4	-0.3	-0.4	-2.0	0.8
Past tobacco smoking	2.1	3.8	7.2	-0.5	2.5	2.7	1.5	1.8
Alcohol usually taken with meals	0.2	0.3	0.8	0.8	-0.0	-0.0	-0.9	-0.3
Nervous feelings	0.7	1.3	4.2	1.3	-0.9	-2.1	0.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	-0.2	-0.0	-0.9	0.5	-0.1
Hearing difficulty/problems with background noise	1.2	1.9	4.5	0.8	-1.2	-2.1	-1.7	-0.3
Hair/balding pattern: Pattern 2	0.8	1.0	2.6	1.2	-0.5	0.2	-1.6	0.7
Had menopause	0.4	0.5	1.0	1.0	0.2	0.4	-1.0	0.7
Had other major operations	0.5	0.6	2.3	-1.5	0.3	0.2	0.4	-0.4
Forced vital capacity (FVC)	0.5	1.8	3.6	-1.9	0.9	0.4	0.9	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	3.1	1.8	-1.3	-1.5	0.3	-1.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.3	0.4	0.1	0.6	0.7
Qualifications: None of the above	0.5	1.0	1.9	-0.3	-1.4	-1.2	-0.3	-1.3
Financial difficulties in last 2 years	0.2	0.2	1.2	-0.1	-0.2	-0.0	1.1	0.2
Mouth/teeth dental problems	0.7	1.1	3.3	-0.1	-0.9	-0.4	-1.8	-1.0
Heart attack	3.8	4.8	11.0	1.5	-2.7	-1.7	-3.3	-0.9
Allergy	1.4	3.3	6.4	1.5	-2.5	-2.1	-1.8	0.0
Pain all over the body in last month	1.3	1.4	4.8	2.2	0.3	-0.4	-0.4	1.4
Diabetes (self-reported)	0.1	0.1	0.7	-0.1	-0.2	0.1	-0.1	-0.8
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.7	-1.2	1.9	1.0	1.2	0.8
Medication: Ramipril	0.3	0.3	1.5	0.4	-0.1	0.0	-1.2	0.2
Medication: Simvastatin	2.3	3.4	5.4	0.3	-2.3	-2.2	-2.1	-1.4
Fluid intelligence score	0.3	0.7	1.8	-1.3	0.5	0.8	0.8	0.2
Illnesses of siblings	0.4	0.5	1.3	-1.1	0.7	0.7	0.5	0.4
Neuroticism score	0.7	1.4	4.6	1.1	-0.5	-2.1	-0.9	-0.0
Weight	0.4	2.0	2.9	-1.5	-1.7	-1.4	-0.5	-1.7
Impedance of arm (right)	0.7	3.5	7.0	1.0	-1.9	-2.4	0.1	-2.6
Arm fat percentage (right)	1.1	4.4	10.6	-0.3	-2.5	-2.2	-0.6	-3.3
Trunk fat-free mass	0.4	2.6	11.2	-3.3	0.7	0.8	0.7	0.3
Hip circumference	0.3	1.4	2.9	-1.7	-1.3	-0.5	-0.7	-1.2
Time employed in main current job	0.4	0.5	0.8	0.9	-0.9	-0.7	0.0	0.3
Alcohol intake versus 10 years previously	1.0	1.5	3.1	-0.6	1.0	1.8	1.1	1.4
Father’s age at death	0.3	0.4	1.2	-0.4	-0.2	-0.5	-0.4	-1.1
Worrier / anxious feelings	1.0	1.9	4.6	2.1	-0.3	-1.8	-1.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.2	-0.5	-1.0	-0.2	0.4
Falls in the last year	0.3	0.4	0.9	0.2	-0.3	-0.1	-0.9	0.9
Hair/balding pattern: Pattern 3	0.9	1.4	3.6	-1.9	0.7	0.6	1.3	-1.0
Number of live births	0.3	0.4	2.2	-0.2	0.1	0.1	1.5	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.9	-2.2	0.9	0.6	1.1	1.8
Pulse rate	1.0	1.7	3.5	1.2	-1.9	-1.4	-0.5	-1.1
Happiness	0.2	0.3	0.5	-0.1	0.3	-0.7	-0.6	0.7
Noisy workplace	3.0	3.7	7.0	-0.6	2.6	1.9	1.2	2.5
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.9	0.7	-0.3	0.2	-2.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	5.2	6.0	9.3	-2.2	2.7	3.0	1.7	2.4
Mouth/teeth dental problems: Dentures	0.7	1.2	2.3	0.8	1.1	0.7	1.5	1.2
Asthma	0.6	1.1	1.8	-0.7	1.3	1.3	1.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.0	4.7	-2.2	-1.7	-1.7	1.5	-1.5
Medication: Cholesterol lowering	1.0	1.6	5.3	-2.3	-0.9	-0.5	0.6	-1.1
Depression (self-reported)	0.4	0.5	1.4	0.6	0.4	-0.2	-0.6	1.2
Medication: Lansoprazole	2.5	2.8	5.5	0.2	-1.9	-2.1	-2.4	-0.9
Prospective memory result	0.0	0.0	0.0	-0.2	-0.0	-0.0	0.1	0.0
Lung cancer (father)	0.2	0.3	0.7	0.3	-0.3	-0.8	-0.7	0.3
Illnesses of mother	0.6	0.7	1.5	-1.2	0.8	0.5	0.8	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	6.3	-2.5	0.6	0.3	0.8	0.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	0.9	-1.2	-0.5	-0.6	0.3
Impedance of arm (left)	0.5	2.3	4.1	1.4	-1.3	-2.0	0.5	-1.9
Arm fat mass (right)	0.8	3.4	6.4	-0.7	-2.4	-2.0	-0.7	-2.5
Trunk predicted mass	0.4	2.5	11.0	-3.3	0.7	0.8	0.7	0.3
Standing height	0.2	1.7	7.1	-2.7	-0.5	-0.5	1.0	-0.2
Length of working week for main job	0.5	0.6	0.9	-0.1	-0.9	-0.8	-0.9	-0.6
Exposure to tobacco smoke at home	0.6	0.6	1.4	-1.2	-0.4	-0.6	1.0	-0.6
Breastfed as a baby	1.3	1.6	3.7	0.3	1.9	0.9	-0.0	1.9
Tense / ‘highly strung’	0.2	0.3	0.7	0.8	0.2	-0.8	0.5	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	5.2	-0.1	-1.5	-2.3	-0.1	-1.4
Hair/balding pattern: Pattern 4	1.3	3.1	5.4	2.2	-1.1	-1.8	-2.3	-0.8
Birth weight of first child	0.5	0.8	2.7	-1.6	0.5	0.8	0.1	0.8
Peak expiratory flow (PEF)	2.5	5.7	13.0	-3.6	1.9	1.8	2.9	0.7
Pulse wave reflection index	0.5	0.6	1.1	-0.5	0.8	1.1	0.7	0.8
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.9	-0.6	-0.3	-0.9	0.2	0.3
Loud music exposure frequency	0.9	1.0	1.8	-0.0	1.3	0.9	0.9	1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.8	0.2	1.3	0.8	0.1	1.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	-1.0	-1.1	-0.7	0.2	-0.1
Blood clot in the leg (DVT)	0.2	0.2	0.9	0.2	-0.1	-0.3	0.3	-1.0
Medication: Paracetamol	0.6	0.9	2.8	-0.6	-0.4	-1.1	1.7	-0.4
Headache pain in last month	1.4	2.4	3.8	-1.9	1.5	0.6	1.9	1.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.1	1.8	0.3	0.0	0.5	0.3
Glaucoma (self-reported)	0.2	0.3	0.6	-0.4	0.5	0.4	0.8	0.4
Gout (self-reported)	0.2	0.3	0.6	-0.1	0.5	0.4	-0.7	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.8	0.1	0.9	0.3	0.3	0.2
Medication: Amlodipine	0.3	0.5	1.4	-1.2	0.4	0.6	-0.6	0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.2	0.8	1.5	0.6	0.5	-0.5
Birth weight	1.1	2.3	9.7	-3.1	0.5	0.4	1.0	-0.5
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.0	0.4	-1.4	-0.9	0.6	-1.0
High blood pressure (siblings)	0.1	0.1	0.4	0.6	-0.0	-0.0	0.2	-0.1
Forced vital capacity (FVC), Best measure	0.6	2.4	6.3	-2.5	1.2	0.9	1.2	1.4
Body fat percentage	1.8	7.3	13.0	0.3	-3.6	-3.1	-1.1	-3.5
Leg fat percentage (right)	2.2	8.1	14.7	0.9	-3.8	-3.2	-1.9	-3.3
Arm fat-free mass (right)	0.2	1.1	5.3	-2.3	0.0	0.3	0.2	0.2
Exposure to tobacco smoke outside home	0.5	0.7	1.1	-1.0	0.3	0.6	0.9	1.0
Comparative body size at age 10	0.1	0.3	0.5	-0.7	0.3	0.5	-0.3	0.6
Number of full brothers	0.5	0.6	1.9	1.4	-0.3	-0.8	-0.4	0.6
Worry too long after embarrassment	0.7	1.2	2.9	1.2	0.1	-1.7	-1.0	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	-0.4	-0.7	-0.4	-0.3
Wheeze or whistling in the chest in last year	0.2	0.3	1.0	0.3	-0.4	-1.0	-0.1	-0.3
Number of children fathered	1.2	1.4	4.7	0.8	0.7	0.7	-0.8	2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.5	-0.3	-0.7	0.1	-0.0	-1.2
Age at first live birth	0.3	0.5	1.8	-0.3	0.7	0.4	1.3	0.2
Pulse wave peak to peak time	0.6	0.7	1.4	-1.2	1.1	0.4	0.7	-0.5
Health satisfaction	1.0	1.3	3.5	1.9	0.0	-1.1	-0.7	1.2
Shortness of breath walking on level ground	0.1	0.1	0.5	-0.0	0.3	-0.0	0.7	-0.0
Qualifications: College or University degree	0.1	0.2	0.4	0.6	0.7	0.2	-0.5	-0.2
Eye problems/disorders: None of the above	0.4	0.5	1.4	-1.0	0.0	0.2	1.2	0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-1.0	-0.8	-0.1	0.1	-1.0
Emphysema/chronic bronchitis	0.2	0.2	0.9	-1.0	0.1	-0.1	-0.0	0.1
Medication for pain relief, constipation, heartburn	0.8	1.4	2.6	1.2	0.7	1.6	-1.6	0.2
Neck or shoulder pain in last month	0.6	0.9	2.7	-1.6	-0.7	-0.8	0.4	-0.5
Medication: Blood pressure	0.4	0.7	2.8	-0.0	-0.7	-0.4	-1.7	0.2
Angina (self-reported)	0.8	1.0	2.4	1.2	-0.3	-0.4	-1.5	0.9
Migraine (self-reported)	2.7	3.4	6.4	-2.4	1.6	1.5	2.5	0.1
Medication: Ibuprofen	1.4	1.7	3.0	-1.7	-1.3	-1.4	0.7	-1.1
Medication: Allopurinol	0.1	0.2	0.6	-0.8	0.1	-0.2	0.0	-0.5
Medication: Omeprazole	0.8	1.0	3.3	-1.0	0.6	0.5	1.8	-0.4
Medication: Seretide 50 evohaler	0.6	0.7	1.3	0.7	1.1	0.6	1.1	0.1
Mean time to correctly identify matches	2.6	4.9	11.3	1.9	-2.0	-3.4	-1.9	-1.3
Heart disease (mother)	0.4	0.5	1.2	0.4	0.6	1.1	-0.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	0.5	0.2	0.1	0.0	-0.6
Whole body fat mass	1.4	5.7	10.8	-0.4	-3.3	-2.7	-1.0	-3.1
Leg fat mass (right)	1.6	6.3	11.6	0.1	-3.4	-2.8	-1.4	-3.2
Arm predicted mass (right)	0.2	1.0	4.8	-2.2	-0.1	0.2	0.2	0.3
Pulse rate, automated reading	2.3	7.6	18.1	4.3	-2.5	-2.7	-1.4	-2.0
Alcohol intake frequency.	2.1	4.9	8.9	-0.3	3.0	2.2	2.0	2.6
Comparative height size at age 10	1.0	5.3	9.7	-1.4	-3.1	-2.5	-1.6	-2.5
Number of full sisters	1.3	1.5	2.5	1.3	-1.1	-0.9	-1.6	1.3
Suffer from ‘nerves’	0.4	0.6	2.0	1.1	0.1	-1.4	0.2	0.0
Overall health rating	2.5	5.5	10.1	2.3	-2.0	-2.8	-3.2	-0.5
Chest pain or discomfort	0.2	0.3	0.8	-0.2	-0.4	-0.9	-0.8	0.1
Had major operations	3.6	4.2	8.2	1.1	-2.9	-2.9	-1.3	-1.4
Age at last live birth	0.1	0.2	0.4	-0.1	-0.4	-0.6	0.6	0.2
Family relationship satisfaction	0.8	1.0	2.0	-1.4	1.1	-0.1	1.2	0.2
Leg pain on walking	0.1	0.1	0.6	0.8	-0.0	-0.4	-0.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.3	0.7	-0.0	0.1	-1.0	1.5
Commuting to job workplace: Car/motor vehicle	1.3	1.4	2.9	-0.6	1.5	1.0	1.7	0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.9	0.6	-0.3	-0.6	-1.4	-0.2
Medication: Aspirin	0.2	0.3	0.6	0.8	-0.3	-0.6	-0.4	0.5
Supplements: Vitamin C	2.1	2.5	6.5	-2.6	-0.8	-1.1	0.9	-1.9
Knee pain experienced in last month	0.8	1.3	3.1	0.8	-1.8	-1.2	-1.1	-0.0
Hypertension (Self-reported)	1.6	4.3	11.6	2.8	-0.9	-0.7	-3.4	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	1.9	3.4	-0.0	-1.8	-1.7	-1.7	-0.8
Illnesses of father: Heart disease	1.3	1.9	3.6	1.9	-1.3	-1.5	-1.1	-0.7
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.4	-0.9	-0.4	-0.8	-0.0
Smoking status: Previous	1.8	2.7	4.0	1.0	-2.0	-2.0	-1.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.9	-1.7	-0.0	-0.1	1.2	-0.5
Whole body fat-free mass	0.4	2.4	10.4	-3.2	0.6	0.7	0.7	0.3
Leg fat-free mass (right)	0.4	2.1	9.3	-3.0	0.6	0.6	0.7	0.3
Arm fat percentage (left)	1.0	3.9	8.6	0.1	-2.4	-2.2	-0.5	-2.9
Average weekly red wine intake	0.7	1.1	2.4	0.8	-1.5	-0.8	-1.2	-0.6
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.4	0.2	-1.3	-1.2	0.0	-1.9
Mood swings	0.4	0.7	2.0	-0.8	0.1	-1.4	0.5	-0.8
Loneliness, isolation	0.2	0.2	0.6	-0.8	0.2	-0.3	0.4	0.5
Long-standing illness, disability or infirmity	1.1	1.6	3.1	1.8	-0.6	-1.7	-1.3	0.4
Ever had bowel cancer screening	0.6	0.7	1.5	-0.5	-0.8	-1.2	0.3	-1.0
Diabetes diagnosed by doctor	0.3	0.6	1.6	0.1	-0.7	-0.8	-0.3	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.8	-0.9	-0.4	0.1	-0.4
Friendships satisfaction	1.0	1.3	3.1	-0.1	-0.4	-1.7	-1.6	-0.8
Qualifications: nursing, teaching	1.5	2.4	5.0	-0.4	2.2	2.2	1.3	0.3
Commuting to job workplace: Walk	0.1	0.1	0.4	-0.0	-0.1	0.5	0.7	-0.0
Eye problems/disorders: Cataract	1.0	1.2	2.8	0.9	1.7	1.3	-0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.6	1.2	1.2	0.2	1.1	0.7
Medication for cholesterol	5.5	8.4	17.2	-4.1	1.7	2.1	4.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	3.3	-0.4	-1.8	-1.7	-1.0	-1.3
Back pain experienced in last month	0.5	0.7	1.3	-1.1	-0.2	-0.9	0.7	-1.0
Mineral and other dietary supplements	0.7	0.9	2.4	1.5	-0.5	0.2	-0.5	1.2
Breast cancer (self-reported)	1.2	1.4	2.8	0.1	1.4	1.3	0.7	1.7
Asthma (self-reported)	0.9	1.7	2.9	-0.8	1.7	1.7	1.4	0.3
Osteoporosis (self-reported)	2.1	2.5	4.1	1.3	-1.8	-1.9	-2.0	0.0
Osteoarthritis (self-reported)	5.0	6.5	13.5	0.8	-3.1	-3.7	-0.7	-2.9
Medication: Aspirin	0.2	0.3	0.5	0.6	0.0	-0.2	-0.6	0.7
Medication: Gliclazide	2.5	2.8	6.7	-1.9	-0.7	-0.3	1.8	-2.6
Illnesses of father: None of the above (group 1)	0.7	0.9	1.8	-1.4	0.4	1.2	0.4	1.0
Smoking status: Current	0.7	1.2	2.5	-0.7	-1.3	-1.6	0.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.4	-1.2	-0.7	-0.6	0.4	-0.3
Whole body water mass	0.4	2.1	9.2	-3.0	0.5	0.7	0.7	0.4
Leg predicted mass (right)	0.4	2.2	9.4	-3.1	0.7	0.7	0.6	0.4
Arm fat mass (left)	0.9	3.6	6.3	-0.2	-2.4	-2.1	-1.0	-2.5
Number of self-reported non-cancer illnesses	0.7	1.2	2.6	-0.1	-1.4	-1.6	-0.8	-1.0
Average weekly champagne plus white wine intake	0.5	0.8	1.9	-0.2	0.1	-0.8	1.1	-1.4
Miserableness	0.3	0.5	1.5	0.4	0.5	-0.6	0.5	1.2
Guilty feelings	0.2	0.3	1.0	-0.7	0.1	-1.0	-0.1	0.2
Wears glasses or contact lenses	0.2	0.3	0.5	0.5	-0.6	0.1	-0.7	-0.4
Ever taken oral contraceptive pill	0.8	0.9	2.8	-0.4	1.0	0.1	1.7	-0.9
Hearing aid user	0.7	0.8	3.0	1.7	-0.2	-0.8	-0.3	0.4
Mother’s age at death	1.5	1.9	3.9	-1.9	0.3	-0.3	1.2	-2.0
Financial situation satisfaction	0.3	0.3	1.0	-0.1	-1.0	-0.7	-0.3	-0.2
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.4	-1.0	0.2	0.4	1.2	-0.3
Commuting to job workplace: Public transport	1.2	1.5	2.7	0.5	-1.5	-1.3	-1.7	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.2	-0.1	-0.0	-0.4	0.4
Medication: Blood pressure	2.6	4.9	12.0	3.3	-0.6	-0.7	-3.5	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.9	-1.4	0.1	0.3	0.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.6	-1.9	0.6	0.4	0.2	-1.0
High cholesterol (Self-reported)	0.2	0.4	1.0	0.5	-0.6	-0.7	-1.0	-0.2
Medication: Bendroflumethiazide	0.5	0.8	1.9	1.4	0.2	-0.2	-1.0	1.1
Medication: Paracetamol	0.7	1.1	3.0	-0.1	-0.8	-1.7	1.2	-0.6
Medication: Lisinopril	7.7	10.0	18.8	3.5	-3.3	-2.8	-4.3	0.1
Medication: Atorvastatin	0.9	1.1	2.4	0.4	0.9	1.0	1.1	1.6
Illnesses of father: High blood pressure	0.2	0.3	1.2	0.2	-0.0	-0.2	1.1	0.5
Alcohol drinker status: Never	3.6	4.4	11.2	1.6	2.5	1.3	0.2	3.3
Ever smoked	1.5	2.7	5.1	-0.6	-1.8	-2.1	-0.5	-2.3
Basal metabolic rate	0.3	1.7	8.1	-2.8	0.1	0.3	0.5	-0.2
Leg fat percentage (left)	2.0	7.2	12.8	0.4	-3.6	-2.9	-1.9	-3.4
Arm fat-free mass (left)	0.2	1.0	4.7	-2.2	-0.2	0.2	-0.1	0.1
Number of operations (self-reported)	1.4	2.0	3.1	-1.3	-1.4	-1.3	1.3	-1.8
Average weekly beer plus cider intake	0.8	1.2	3.4	-0.7	1.0	1.0	1.8	0.4
Irritability	1.2	2.0	5.0	1.1	-1.4	-2.2	-1.1	-0.7
Risk taking	0.1	0.1	0.3	-0.0	0.4	0.1	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.7	0.5	0.5	-0.1	-0.2
Fractured/broken bones in last 5 years	0.5	0.6	2.5	-1.6	0.5	-0.4	0.3	-0.5
Age started oral contraceptive pill	0.2	0.3	1.1	1.1	-0.3	-0.4	0.3	-0.1
Diastolic blood pressure, automated reading	0.5	1.5	3.5	0.9	0.9	1.9	-0.1	1.5
Ever depressed for a whole week	0.9	1.1	2.3	-0.6	-0.7	-1.5	0.9	-1.3
Unable to work because of sickness or disability	0.2	0.3	0.5	0.0	0.2	-0.6	0.7	0.7
Commuting to job workplace: Cycle	1.5	1.8	3.1	0.1	1.7	1.7	0.1	1.8
Myopia	1.1	1.6	5.0	-0.1	-1.1	-1.4	-0.2	-2.2
Vascular/heart problems diagnosed by doctor	1.2	3.4	9.6	-2.2	0.6	0.5	3.1	-1.4
Cholesterol lowering medication	2.6	3.9	10.8	3.3	-0.6	-0.9	-2.6	0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.4	0.6	0.4	1.1	0.3
Pain experienced in last month	0.3	0.5	1.8	1.4	-0.1	0.5	-0.5	-0.6
Supplements: Calcium	0.3	0.4	1.2	0.5	1.1	0.3	0.3	0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.4	0.0	0.4	-0.4	0.5
Heart attack/myocardial infarction (self-reported)	3.1	4.0	8.6	1.1	-2.6	-1.6	-2.9	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.0	-0.2	-0.1	-0.5	0.3	-1.0
Heart disease (siblings)	0.7	0.9	1.4	1.1	-1.1	-1.2	-0.2	-0.7
Alcohol drinker status: Previous	0.4	0.5	1.4	-0.4	0.1	-0.3	0.9	-1.2
Pack years of smoking	1.5	2.2	4.5	-1.0	1.4	0.8	2.1	1.7
Impedance of whole body	0.7	3.4	5.4	1.9	-2.0	-2.3	-0.2	-2.0
Leg fat mass (left)	1.5	5.8	10.3	-0.3	-3.2	-2.6	-1.4	-3.2
Arm predicted mass (left)	0.2	1.0	5.0	-2.2	-0.4	-0.1	-0.2	-0.1