TWAS hub - ARHGEF18

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0995	0.0156	0.0e+00	0.124	0.104	0.124	0.125	0.123	7.9e-38	1.0e-31	5.9e-38	2.7e-38	1.3e-37
2	ROSMAP	Brain Pre-frontal Cortex	0.0739	0.0215	2.4e-05	0.062	0.035	0.035	0.038	0.055	1.9e-08	2.5e-05	2.2e-05	9.4e-06	1.4e-07
3	YFS	Blood	0.0314	0.0120	3.9e-03	0.000	0.001	0.001	0.004	-0.001	3.2e-01	1.8e-01	1.8e-01	1.6e-02	7.2e-01
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0480	0.0207	3.3e-05	0.040	0.037	0.030	NA	0.038	2.5e-05	5.0e-05	2.1e-04	NA	4.1e-05
5	TCGA	Brain Lower Grade Glioma	0.0560	0.0343	6.9e-03	0.005	0.009	0.005	NA	0.011	8.4e-02	2.9e-02	7.1e-02	NA	1.6e-02
6	TCGA	Prostate Adenocarcinoma	0.0777	0.0407	2.0e-03	0.009	0.019	0.021	NA	0.020	3.8e-02	3.7e-03	2.5e-03	NA	3.2e-03
7	TCGA	Thyroid Carcinoma	0.0310	0.0170	7.5e-03	0.008	0.003	-0.002	NA	-0.002	5.5e-02	1.4e-01	6.2e-01	NA	6.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Medication: Ventolin 100micrograms inhaler	5.0	6.4	16.1	1.2	1.8	-0.3	4.0	2.6	2.7	3.1
Lung FEV1/FVC ratio	4.4	22.5	37.7	-4.6	-4.7	-2.0	-6.1	-5.5	-3.3	-5.6
Chronic bronchitis/emphysema (mother)	4.3	5.0	10.8	2.5	3.3	-0.8	1.7	1.9	0.4	3.2
Alcohol drinker status: Previous	3.3	3.8	6.1	2.1	2.1	0.9	2.0	2.2	1.5	2.5
Average weekly red wine intake	3.2	4.8	9.2	-2.4	-2.1	-0.4	-2.3	-2.1	-2.1	-3.0
Average weekly champagne plus white wine intake	3.2	4.4	7.7	2.0	2.0	-1.6	2.2	2.5	1.6	2.8
Chronic bronchitis/emphysema (father)	3.1	3.6	6.8	2.6	2.0	-0.1	2.1	2.4	0.1	2.1
Unable to work because of sickness or disability	2.9	3.8	6.9	2.6	2.0	-1.2	1.9	2.1	0.4	2.5
Taking other prescription medications	2.8	4.3	6.8	2.4	1.6	-0.4	2.5	2.6	1.9	2.3
Had other major operations	2.8	3.4	8.4	2.9	2.3	-0.7	1.6	1.7	0.3	2.1
Medication: Metformin	2.7	3.8	8.9	2.6	3.0	-1.1	1.9	1.5	0.2	2.0
Eye problems/disorders: Cataract	2.6	3.0	7.1	-2.7	-1.3	2.3	-1.1	-1.8	-0.5	-1.5
Medication for cholesterol	2.6	3.9	10.8	0.5	1.2	-2.4	-2.6	-1.5	-3.3	-0.1
Ever had prostate specific antigen (PSA) test	2.6	3.0	6.4	2.5	2.3	-0.0	0.6	1.7	0.3	2.4
Medication: Seretide 50 evohaler	2.5	2.8	6.1	0.6	2.3	0.5	1.7	0.7	2.1	2.5
Long-standing illness, disability or infirmity	2.5	3.8	7.2	2.0	1.5	0.2	2.7	2.0	1.5	2.6
Ever used hormone-replacement therapy (HRT)	2.4	3.0	6.7	0.5	0.9	1.2	2.6	2.1	2.5	1.1
Smoking status: Current	2.4	3.7	9.7	3.1	2.5	1.5	1.3	1.3	-0.3	2.1
Triglycerides	2.3	3.8	5.4	1.9	2.0	0.1	2.3	2.3	1.8	2.2
High blood pressure (mother)	2.3	3.2	9.1	-2.4	-2.1	0.9	1.5	-0.2	3.0	-0.6
Number of live births	2.3	3.3	6.0	2.2	1.9	-1.3	1.4	2.4	1.1	2.0
Peak expiratory flow (PEF)	2.3	5.3	10.8	-3.3	-2.8	-1.0	-1.5	-2.6	-0.1	-2.9
Ever taken oral contraceptive pill	2.3	2.5	7.0	2.0	2.6	-1.3	0.9	1.3	-0.0	1.5
Irritability	2.3	3.9	8.5	2.5	2.9	-2.7	0.7	0.6	-1.2	1.7
Cardiovascular Disease	2.2	7.1	17.5	-3.4	-2.8	1.7	2.8	0.1	4.2	-1.6
Current tobacco smoking	2.2	3.5	9.2	3.0	2.6	1.4	1.2	1.2	-0.4	1.9
Medication: Allopurinol	2.2	3.0	5.4	1.6	1.3	-0.6	2.0	1.8	1.7	2.3
Medication: Blood pressure	2.2	4.2	9.7	-2.1	-2.5	1.9	2.2	0.2	3.1	-1.0
Ulcerative Colitis	2.1	3.0	6.1	-0.8	-0.5	1.6	-2.5	-2.3	-1.7	-1.8
Number of children fathered	2.1	2.4	4.9	2.1	2.2	-1.7	0.5	0.7	-0.4	1.9
Mineral and other dietary supplements	2.1	2.8	7.8	2.8	2.6	0.5	-0.1	0.7	-1.9	1.0
Medication: Lansoprazole	2.0	2.3	4.1	1.6	0.8	0.9	2.0	1.9	1.5	1.4
Wheeze or whistling in the chest in last year	1.9	3.3	7.0	2.2	2.6	-0.4	1.8	1.5	0.9	2.3
Pulse rate, automated reading	1.9	6.1	17.2	3.2	3.1	-1.8	-0.7	0.8	-4.1	1.1
Average weekly beer plus cider intake	1.9	2.7	4.8	1.7	1.7	-0.5	1.3	2.2	1.7	2.0
Allergy or Eczema	1.8	4.7	8.2	1.8	2.2	-1.6	2.9	2.3	1.7	2.4
Waist circumference	1.8	6.4	9.5	2.9	3.1	-2.8	2.3	2.5	-0.2	2.7
Body fat percentage	1.8	7.0	11.6	3.4	3.0	-3.2	2.0	2.6	-0.4	2.6
Leg fat percentage (right)	1.8	6.4	9.5	3.0	3.1	-2.8	2.2	2.5	0.0	2.6
Comparative body size at age 10	1.8	5.1	11.5	-3.4	-3.0	0.4	-1.6	-2.2	1.1	-2.5
Shortness of breath walking on level ground	1.8	2.2	6.5	1.6	2.5	-1.1	1.4	1.5	0.3	0.9
Hypertension (Self-reported)	1.8	4.9	11.7	-2.5	-2.6	0.7	2.9	0.5	3.4	-0.6
Leg fat percentage (left)	1.8	6.5	9.7	3.1	2.9	-2.8	2.2	2.6	0.1	2.7
Number of operations (self-reported)	1.8	2.7	5.2	2.3	1.8	-1.1	1.5	1.8	0.7	1.9
Myopia	1.8	2.7	5.3	1.4	1.5	0.7	2.3	1.8	1.7	1.4
HDL Cholesterol	1.7	2.9	5.0	-1.6	-2.2	1.8	-1.4	-1.7	-0.4	-2.1
Neuroticism (2016)	1.7	2.5	5.3	1.4	1.4	1.2	2.3	1.8	1.8	0.7
Systolic Blood Pressure	1.7	8.6	20.3	-4.5	-4.5	-0.0	1.8	-0.4	3.4	-2.3
Fed-up feelings	1.7	3.0	4.5	2.1	1.8	-1.1	2.1	2.1	0.7	1.8
Asthma	1.7	3.4	7.5	1.0	1.5	-1.4	2.7	1.7	1.3	2.6
Back pain experienced in last month	1.7	2.5	5.4	1.8	1.2	1.0	2.3	1.9	0.9	1.4
Asthma (self-reported)	1.7	3.4	7.8	0.9	1.3	-1.6	2.8	1.7	1.2	2.6
Ever depressed for a whole week	1.7	2.1	5.1	-2.2	-1.8	1.2	-0.5	-1.7	0.8	-1.1
Alzheimer’s Disease (in mother)	1.6	1.9	3.8	-1.0	-1.2	1.1	-1.3	-1.9	-1.1	-1.7
High blood pressure	1.6	4.4	9.1	-2.7	-3.0	0.8	2.3	-0.1	2.7	-1.0
Medication: Amlodipine	1.6	2.3	7.1	0.6	0.1	0.9	2.7	1.7	1.8	1.2
Medication: Blood pressure	1.6	2.9	7.8	-1.8	-1.4	0.3	2.5	0.6	2.8	0.4
Mood swings	1.6	2.9	5.1	2.2	1.9	-0.8	2.0	1.9	1.0	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	6.7	-0.8	-0.5	-2.6	0.9	0.3	1.8	0.3
Osteoarthritis (self-reported)	1.6	2.0	3.5	1.6	1.4	-0.3	1.7	1.7	0.5	1.9
Medication: Lisinopril	1.6	2.0	5.4	-0.5	-0.8	0.5	2.3	1.3	2.3	1.0
Vascular/heart problems diagnosed by doctor	1.6	4.3	7.9	2.8	2.8	-1.4	-2.2	0.1	-2.5	1.2
Fasting Glucose	1.5	1.7	4.1	0.5	1.7	-0.5	1.5	1.2	1.0	2.0
Trunk fat percentage	1.5	6.0	10.9	3.3	2.5	-3.3	1.7	2.3	-0.7	2.3
Allergy	1.5	3.5	6.3	-1.4	-1.7	2.3	-2.5	-1.6	-1.3	-2.0
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	3.6	1.0	1.6	-1.3	1.2	1.3	1.2	1.9
Pulse rate	1.5	2.6	7.6	2.1	2.8	-0.6	0.4	1.1	-1.7	1.2
Migraine (self-reported)	1.5	1.8	4.5	-0.3	-1.5	-1.2	-2.1	-1.2	-1.4	-0.9
Overall health rating	1.5	3.1	8.1	2.9	2.3	-0.2	1.7	1.9	-0.4	1.5
Family relationship satisfaction	1.5	1.8	3.3	-1.1	-1.5	1.7	-1.2	-0.9	-0.7	-1.8
Commuting to job workplace: Walk	1.5	1.6	4.1	2.0	1.7	-0.6	0.6	1.1	-0.2	1.6
Wears glasses or contact lenses	1.5	1.7	2.9	1.7	1.4	-0.1	1.3	1.6	0.6	1.6
Lupus	1.4	2.2	4.5	1.0	1.2	2.1	1.7	1.7	0.7	1.4
Diabetes (father)	1.4	1.8	4.3	-0.2	-0.4	-1.3	-1.7	-1.6	-2.1	-0.8
Supplements: Glucosamine	1.4	1.8	4.7	-2.2	-1.6	0.3	-0.4	-1.4	0.8	-1.5
Financial difficulties in last 2 years	1.4	1.9	3.2	1.6	1.7	-1.6	1.8	0.9	0.3	1.1
Had major operations	1.4	1.6	3.7	1.9	1.3	0.3	1.0	1.5	0.6	1.6
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.3	-1.7	-1.3	-0.5	-1.8	-1.5	-0.1	-1.4
Medication: Bendroflumethiazide	1.4	2.1	5.4	-2.3	-2.1	0.9	1.0	-0.1	1.3	-1.1
Smoking Status	1.3	3.2	9.5	3.1	2.2	-0.5	1.3	1.4	-0.4	2.0
Number of treatments/medications taken	1.3	2.3	6.7	-0.2	-0.6	0.6	2.4	1.1	2.6	1.2
Diabetes (mother)	1.3	1.7	4.1	0.1	-0.0	-0.4	1.9	2.0	1.9	0.8
Townsend deprivation index at recruitment	1.3	1.8	3.6	1.9	1.3	0.6	1.8	1.4	0.0	1.2
Hayfever, allergic rhinitis or eczema	1.3	2.7	5.9	1.1	1.6	-2.4	1.8	1.2	1.3	1.8
Diabetes (self-reported)	1.3	2.0	4.7	2.0	2.2	-0.4	1.5	1.3	-0.8	0.9
Medication for pain relief, constipation, heartburn	1.3	2.3	3.6	-1.0	-0.9	-1.9	-1.8	-1.4	-1.8	-1.6
Whole body fat mass	1.3	5.6	11.7	2.9	2.7	-3.4	1.6	2.0	-0.7	2.3
Alzheimer’s Disease (including proxy)	1.2	1.8	3.3	-1.4	-1.2	1.5	-0.7	-1.7	-0.4	-1.8
Age at First Birth	1.2	1.8	4.0	-2.0	-1.4	0.7	-1.4	-1.4	-0.8	-1.1
Trunk fat mass	1.2	4.9	11.9	2.7	2.4	-3.4	1.4	1.8	-0.7	2.1
Medication: Simvastatin	1.2	1.7	8.9	0.5	-0.2	3.0	1.2	0.8	0.9	0.1
Depression (self-reported)	1.2	1.5	2.7	-0.6	-1.2	-0.3	-1.6	-1.5	-1.0	-1.6
Leg fat mass (right)	1.2	4.6	11.8	2.2	2.5	-3.4	1.5	1.5	-0.3	2.1
Arm fat percentage (left)	1.2	4.7	10.2	2.4	2.5	-3.2	1.7	2.1	-0.3	1.9
Eye problems/disorders: Glaucoma	1.2	1.4	3.7	1.2	1.4	1.3	0.9	1.9	0.5	-0.0
Supplements: Fish oil (including cod liver oil)	1.2	1.6	5.5	-2.3	-1.6	-0.3	0.4	-0.4	1.4	-0.7
Cholesterol lowering medication	1.2	1.8	6.1	0.7	0.0	2.5	1.3	1.2	1.6	-0.1
Alzheimer’s Disease (in father)	1.1	1.2	2.2	-1.4	-0.9	1.4	0.9	-0.2	1.5	-0.8
Type 2 Diabetes (T2D) (2018)	1.1	2.1	5.4	1.4	1.4	-0.4	2.3	1.9	0.7	1.1
Severe depression (siblings)	1.1	1.3	3.8	1.9	0.8	0.7	0.1	0.8	-0.6	1.8
Noisy workplace	1.1	1.4	2.5	-1.5	-1.3	1.0	-0.3	-1.6	1.4	-0.7
Medication: Paracetamol	1.1	1.7	3.1	1.0	1.3	-1.2	1.7	1.2	0.9	1.8
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.0	1.6	1.5	-0.4	-2.0	-0.4	-1.8	0.0
Medication: Aspirin	1.1	1.4	4.6	-1.2	-0.7	2.2	0.6	-0.6	1.7	-0.0
Medication: Aspirin	1.1	1.5	4.1	-0.8	-0.4	2.0	1.0	-0.1	2.0	0.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.4	-1.4	-2.1	0.3	-0.4	-1.1	0.1	-1.1
Diastolic blood pressure, automated reading	1.1	3.3	8.5	-2.9	-2.9	-0.2	1.2	-0.5	1.6	-1.4
Leg fat mass (left)	1.1	4.5	11.2	2.2	2.5	-3.4	1.5	1.5	-0.2	2.1
Blood White Count	1.0	7.7	27.1	2.1	3.6	5.2	1.1	0.9	-1.3	2.3
Medication: Co-codamol	1.0	1.1	2.7	1.5	1.2	-0.2	0.7	0.9	-0.2	1.6
Average weekly fortified wine intake	1.0	1.1	2.1	1.3	1.5	-0.4	1.0	0.7	-0.6	1.5
Relative age voice broke	1.0	1.5	8.4	-0.3	-0.5	2.9	-0.1	-0.3	-0.9	-0.7
Hair/balding pattern: Pattern 2	1.0	1.2	5.3	-0.1	1.2	-2.3	1.1	0.6	0.6	0.3
Arm fat percentage (right)	1.0	3.8	9.9	2.1	2.1	-3.1	1.4	1.8	-0.4	1.5
Alcohol intake versus 10 years previously	1.0	1.5	3.8	-0.2	-0.6	0.9	-1.2	-1.7	-1.9	-0.9
Emphysema/chronic bronchitis	1.0	1.1	2.3	1.4	1.4	-0.2	0.9	0.9	0.1	1.5
Supplements: Vitamin C	1.0	1.1	2.3	0.7	1.2	-0.3	1.5	1.5	0.9	0.8
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.3	0.9	1.1	-1.8	0.7	0.9	0.6	1.3
Illnesses of father: High blood pressure	1.0	1.2	4.0	0.3	-0.3	-0.4	1.2	1.6	2.0	0.5
Risk taking	1.0	1.5	4.0	-0.3	-1.2	-0.9	-1.1	-0.8	-2.0	-1.5
Type 2 Diabetes (T2D) (2012)	0.9	1.0	4.7	-0.5	-0.5	2.2	0.0	0.0	-1.1	-0.8
Waist Hip Ratio (WHR)	0.9	4.2	11.5	2.1	3.4	-1.1	1.3	2.2	-0.7	2.2
Average weekly spirits intake	0.9	1.2	2.1	0.5	0.9	-1.0	1.4	0.9	1.5	1.0
Systolic blood pressure, automated reading	0.9	2.5	7.7	-2.3	-2.8	0.5	0.9	-0.1	1.4	-1.1
Medication for hormone replacement therapy	0.9	1.0	2.1	0.5	-0.5	0.6	1.3	1.0	1.5	1.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	8.6	-2.9	-2.2	0.6	-1.1	-1.9	-0.1	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.2	1.0	0.7	0.2	1.5	1.3	0.8	1.5
Lung cancer (father)	0.9	1.0	3.4	1.8	0.9	0.8	0.4	1.1	-0.1	1.1
Pulse wave Arterial Stiffness index	0.9	1.0	2.4	1.0	1.3	-1.6	-0.2	0.4	-0.0	1.3
Arm fat mass (right)	0.9	3.6	11.4	1.8	2.0	-3.4	1.3	1.5	-0.5	1.6
Length of working week for main job	0.9	1.0	2.0	-1.4	-1.3	-0.4	-0.3	-1.0	-0.7	-1.2
Loud music exposure frequency	0.9	1.0	2.3	-0.7	-0.2	0.8	-0.9	-1.2	-0.9	-1.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.2	-0.4	-1.1	0.3	-1.4	-1.0	-1.4	-1.5
Exposure to tobacco smoke outside home	0.9	1.2	3.2	1.8	1.6	-0.6	0.6	0.9	-0.6	0.8
Loneliness, isolation	0.9	1.2	2.8	-0.9	-1.7	0.2	-1.0	-1.3	-0.6	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.7	0.1	0.4	-0.9	1.3	1.0	2.2	1.1
Arm fat mass (left)	0.9	3.7	11.4	1.9	2.1	-3.4	1.3	1.4	-0.5	1.6
Age started oral contraceptive pill	0.9	1.1	2.5	-1.5	-1.6	-1.2	-0.0	-0.1	0.5	-1.2
Major Depression (MDD)	0.8	1.0	2.5	0.1	0.1	1.6	-1.5	-1.1	-0.9	-0.1
Ovarian Cancer	0.8	1.1	2.3	0.9	1.5	-0.1	1.2	1.3	0.4	1.0
Hand grip strength (left)	0.8	2.1	6.5	-2.5	-1.1	0.7	-1.2	-1.8	0.6	-1.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	-1.0	-0.6	-0.8	-0.9	-1.3	-0.7	-1.1
Nervous feelings	0.8	1.5	3.7	1.1	0.3	0.4	1.9	1.9	1.2	0.7
Medication: Ramipril	0.8	1.1	3.5	-0.1	0.6	-0.7	1.9	0.5	1.6	0.5
Pulse wave peak to peak time	0.8	1.0	2.2	-1.0	-1.2	1.5	0.2	-0.5	-0.0	-1.3
Chest pain or discomfort	0.8	1.1	3.1	0.2	0.1	0.1	-1.8	-1.3	-1.7	-0.7
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.7	-1.9	-0.1	-0.1	-0.5	-1.1	-0.6	-0.8
Knee pain experienced in last month	0.8	1.2	5.3	0.7	0.7	-2.3	0.4	-0.1	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.0	1.6	1.7	-0.3	1.4	1.2	0.3	1.6
Diabetes diagnosed by doctor	0.8	1.3	2.5	1.4	1.6	-0.8	1.4	1.2	-0.4	0.7
Qualifications: nursing, teaching	0.8	1.3	2.8	-1.6	-1.5	0.1	-0.2	-0.3	1.2	-1.7
High cholesterol (Self-reported)	0.8	1.4	6.6	0.4	0.1	2.6	1.2	0.6	1.1	-0.1
Ulcerative Colitis (UC)	0.7	1.3	3.8	-0.3	0.1	1.9	-1.2	-1.6	-0.4	-1.0
Breast Cancer	0.7	1.6	4.8	-2.2	-1.6	0.3	-0.3	-1.3	0.3	-1.4
Mean Putamen Volume	0.7	0.9	1.7	0.2	-0.7	1.1	1.1	1.0	1.3	-0.5
Respiratory disease	0.7	1.5	4.5	0.3	1.2	-1.5	1.3	0.3	0.7	2.1
Maternal smoking around birth	0.7	1.0	2.1	1.3	0.7	-1.0	-1.1	-0.4	-1.5	0.7
Medication: Atenolol	0.7	0.9	3.0	-0.8	-0.1	0.6	1.6	0.1	1.7	-0.4
Body mass index (BMI)	0.7	3.0	9.0	1.4	1.8	-3.0	1.5	1.4	-0.1	1.5
Impedance of leg (left)	0.7	3.3	6.0	2.5	1.9	0.9	1.7	2.2	1.1	2.0
Past tobacco smoking	0.7	1.2	3.1	-1.8	-0.9	0.7	-1.1	-1.1	0.6	-1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.2	-2.3	-0.7	-0.4	-0.8	-1.2	1.1	-1.3
Mouth/teeth dental problems: Dentures	0.7	1.3	3.9	2.0	1.4	0.4	-0.4	-0.1	-1.5	0.7
Prospective memory result	0.7	0.8	2.2	-0.8	-1.1	1.5	0.6	0.4	0.9	-0.7
Pulse wave reflection index	0.7	0.9	4.1	-0.9	-0.8	0.1	0.5	0.3	2.0	0.3
Age at first live birth	0.7	1.3	4.8	-2.2	-0.8	0.4	-0.5	-0.8	1.4	-0.7
Medication: Ibuprofen	0.7	0.9	2.1	0.8	0.6	0.5	1.2	1.2	0.5	1.5
Medication: Omeprazole	0.7	0.8	1.9	-0.2	-0.7	1.2	-0.8	-0.6	-1.4	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.9	1.1	1.4	0.6	0.3	1.1	0.8	1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.1	-0.7	-1.2	1.5	-0.5	-0.6	-0.3	-0.9
Body Mass Index (BMI) (2010)	0.6	0.8	1.5	0.7	0.8	0.6	1.0	1.2	0.7	1.2
Primary Biliary Cirrhosis	0.6	0.8	2.9	-0.6	-0.5	-0.4	1.7	0.4	1.3	0.3
Rheumatoid Arthritis	0.6	0.9	4.2	0.6	0.5	2.0	0.0	-0.2	-0.7	0.8
Sensitivity / hurt feelings	0.6	1.1	2.8	-1.7	-1.0	1.2	0.2	-1.0	0.7	-0.9
Hearing difficulty/problems: Yes	0.6	1.0	1.6	1.0	0.9	-0.5	0.7	1.1	1.3	1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.3	1.5	1.1	-0.8	0.4	0.8	-0.2	0.7
Impedance of leg (right)	0.6	3.0	5.5	2.3	2.0	0.8	1.6	2.0	0.9	1.8
Hand grip strength (right)	0.6	1.5	4.1	-2.0	-0.8	0.3	-1.0	-1.6	0.4	-1.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.8	0.7	1.1	-0.5	0.6	1.4	-0.0	0.7
Serious illness, injury or assault to yourself	0.6	0.7	1.5	0.9	1.2	0.7	0.7	1.2	0.4	0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.4	0.4	1.1	0.6	1.0	0.9	0.5	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	3.0	1.2	0.1	1.7	0.7	0.8	1.0	0.6
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.9	-0.9	-0.4	1.0	-1.1	-1.2	-0.5	-1.4
Glaucoma (self-reported)	0.6	0.8	1.9	1.3	1.0	0.8	0.4	1.4	-0.3	-0.1
Heart disease (mother)	0.6	0.7	1.2	-0.6	-1.1	0.7	-1.0	-0.9	0.2	-1.0
Suffer from ‘nerves’	0.6	0.9	2.1	-0.8	-1.2	-1.1	-0.6	-1.4	-0.2	-0.7
Illnesses of father: Heart disease	0.6	0.8	3.9	0.0	-0.4	2.0	-0.7	-0.5	-0.3	-1.0
Smoking status: Previous	0.6	0.9	2.1	1.0	0.6	-1.4	0.9	1.0	-0.3	0.9
Medication: Paracetamol	0.6	0.9	1.8	0.5	0.7	-0.8	1.3	0.9	0.8	1.3
Heart disease (siblings)	0.6	0.7	1.7	0.8	0.9	-0.3	1.3	1.2	-0.5	0.0
Depressed Affect (Nagel 2018)	0.5	1.0	2.6	1.6	0.7	-1.2	1.0	1.1	0.0	0.3
Prostate Cancer	0.5	0.7	1.7	-0.8	-0.5	-1.2	-0.5	-1.3	-0.3	-0.4
LDL Cholesterol	0.5	0.8	3.0	0.3	0.9	1.7	0.6	0.8	0.8	0.2
Chronotype (morning person)	0.5	1.2	4.9	-0.2	-1.0	1.2	0.2	1.1	2.2	-0.3
Relative age of first facial hair	0.5	1.0	5.0	-0.5	-0.5	2.2	-0.8	-0.5	-0.5	-0.6
Supplements: Zinc	0.5	0.6	1.4	0.5	0.7	-0.6	0.9	0.8	0.1	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.3	1.0	0.6	-1.8	-0.5	-0.7	-1.7	-0.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	-1.3	-1.3	0.8	-0.8	-1.0	-0.0	-0.5
Breastfed as a baby	0.5	0.6	1.4	0.1	-0.3	1.2	1.0	1.1	0.2	0.7
Birth weight of first child	0.5	0.8	2.7	0.7	1.6	-1.0	0.9	0.4	-0.7	0.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	0.5	1.1	0.6	0.5	0.6	0.7	1.0
Birth weight	0.5	1.1	2.3	1.3	1.5	0.3	0.5	1.2	-0.2	1.3
Health satisfaction	0.5	0.6	1.5	1.2	0.9	0.8	0.8	0.7	-0.1	0.4
Leg pain on walking	0.5	0.6	1.6	0.5	1.0	0.2	-0.6	-0.9	-1.3	0.6
Number of self-reported non-cancer illnesses	0.5	0.9	2.8	0.1	0.3	-1.0	1.7	0.7	1.3	0.5
Hearing aid user	0.5	0.5	1.3	1.0	1.1	-0.6	-0.8	0.2	-0.2	0.6
Mother’s age at death	0.5	0.6	1.6	-0.6	-1.3	0.2	-0.4	-0.7	-0.0	-1.1
Depression (Nagel 2018)	0.4	0.6	1.6	-0.2	-1.0	-0.4	-0.8	-0.9	-0.6	-1.2
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.1	0.7	0.6	-1.8	0.9	1.4	1.2	0.5
Coronary Artery Disease (CAD)	0.4	0.5	2.0	0.0	0.0	0.8	0.0	-0.7	0.1	-1.4
Crohns Disease (2012)	0.4	0.7	2.2	-1.5	-0.9	0.1	-0.0	-0.4	1.1	-0.6
Lung FVC	0.4	2.0	4.2	1.2	0.9	0.8	1.7	2.0	1.0	1.7
Vitamin and mineral supplements	0.4	0.6	1.9	0.3	-0.2	1.4	-0.7	-0.7	-0.8	-0.6
Age when periods started (menarche)	0.4	0.9	2.0	0.7	1.4	-0.2	0.9	1.0	0.6	1.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.2	-1.0	-0.4	-0.1	-0.5	-1.1	-0.1	-0.6
Fluid intelligence score	0.4	0.8	3.5	0.6	0.4	-1.9	-0.5	-0.1	-1.2	0.2
Weight	0.4	1.9	9.2	0.9	1.2	-3.0	0.8	0.5	-0.5	1.0
Hip circumference	0.4	1.8	3.8	1.8	1.2	-1.9	1.0	1.2	-0.6	1.2
Time employed in main current job	0.4	0.5	0.8	-0.8	-0.7	0.3	0.9	0.5	0.8	0.9
Father’s age at death	0.4	0.5	1.3	0.0	0.7	0.2	1.2	1.1	0.8	0.3
Medication: Cholesterol lowering	0.4	0.6	2.7	-0.3	-0.8	1.6	1.0	0.0	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.0	-1.7	-1.3	0.6	-1.1	-1.4	-0.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.4	1.1	1.2	-0.7	-0.6	0.1	-0.3	0.4
Eye problems/disorders: None of the above	0.4	0.4	0.9	0.9	0.2	-1.0	0.4	0.0	0.5	0.9
Neck or shoulder pain in last month	0.4	0.6	2.1	0.4	-0.1	1.5	-0.5	-0.3	-1.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.8	0.7	1.4	-0.2	0.1	-0.2	-0.1	0.8
Number of full sisters	0.4	0.5	1.1	0.7	0.9	-0.3	1.1	0.8	-0.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.9	0.6	0.6	0.9	0.9	0.5	-0.6	0.2
Illnesses of siblings: Diabetes	0.4	0.5	1.2	1.1	0.2	-0.7	0.4	1.0	-0.2	0.6
Breast cancer (self-reported)	0.4	0.5	1.5	0.5	-0.7	-0.8	-0.0	0.0	-1.2	-0.3
Miserableness	0.4	0.7	1.6	1.0	0.8	-0.4	1.1	1.3	-0.0	0.4
Bipolar Disorder (2018)	0.3	0.4	1.3	0.1	1.1	-0.1	0.4	1.0	0.0	0.6
Neuroticism (Nagel 2018)	0.3	0.7	2.5	0.7	0.5	-0.9	1.6	0.8	0.4	0.2
Crohns Disease (2017)	0.3	0.7	3.2	-0.5	0.2	0.0	1.1	0.4	1.8	0.3
Reaction Time	0.3	0.6	3.4	0.4	0.4	-0.0	-0.7	-0.4	-1.8	-0.1
HbA1C	0.3	0.4	1.9	-1.4	0.2	0.5	0.5	0.0	-0.4	0.0
BMI	0.3	1.5	8.7	0.6	0.6	-3.0	0.2	0.5	-0.8	0.1
Hypothyroidism (self reported)	0.3	0.7	3.1	-0.5	-0.7	-0.6	-0.7	-0.4	-0.4	-1.8
Ever had hysterectomy (womb removed)	0.3	0.4	0.8	-0.2	-0.5	-0.7	-0.7	-0.7	0.0	-0.9
Pack years adult smoking proportion	0.3	0.5	1.6	-0.0	0.9	-1.2	0.1	-0.4	-0.7	0.6
Leg fat-free mass (left)	0.3	1.8	6.8	-0.9	-0.3	-2.6	-1.0	-1.4	-1.3	-0.4
Multivitamins +/- minerals	0.3	0.3	0.9	-0.9	-0.5	-0.8	-0.0	-0.4	0.4	0.1
Leg predicted mass (left)	0.3	1.7	6.4	-0.9	-0.4	-2.5	-1.0	-1.4	-1.2	-0.5
Number of incorrect matches in round	0.3	0.5	1.7	0.0	0.4	1.3	-0.7	-0.9	-0.4	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.8	0.6	0.8	-0.7	-0.3	-0.9	-0.4
Had menopause	0.3	0.3	0.9	0.8	-0.4	1.0	-0.5	0.0	-0.5	-0.4
Qualifications: None of the above	0.3	0.7	2.0	1.4	0.5	0.3	0.6	0.9	-0.9	0.9
Pain all over the body in last month	0.3	0.3	1.3	-0.2	-0.1	-1.2	-0.2	-0.0	-0.7	-0.5
Illnesses of siblings	0.3	0.5	1.2	-0.9	-0.1	0.0	-1.1	-0.8	0.5	-0.5
Neuroticism score	0.3	0.7	1.5	1.1	1.1	-0.5	1.2	0.6	0.0	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.1	1.0	1.1	-0.1	0.6	0.9	0.3	0.6
Falls in the last year	0.3	0.4	0.8	0.8	0.1	0.3	-0.6	-0.4	-0.9	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.1	0.3	0.3	0.3	-0.6	-0.6	-1.0	0.3
Illnesses of mother	0.3	0.4	1.2	1.1	0.9	0.3	-0.4	0.2	-0.7	-0.0
Exposure to tobacco smoke at home	0.3	0.3	0.6	-0.5	-0.7	0.3	-0.5	-0.2	-0.7	-0.7
Hair/balding pattern: Pattern 4	0.3	0.6	1.6	-0.3	-1.3	0.9	1.2	0.2	0.4	-0.1
Blood clot in the leg (DVT)	0.3	0.3	0.8	0.3	-0.6	0.2	-0.8	-0.6	-0.9	-0.3
Gout (self-reported)	0.3	0.4	1.7	0.7	1.3	-0.3	0.2	-0.2	-0.3	0.4
Worry too long after embarrassment	0.3	0.5	1.5	-0.3	0.2	1.1	1.2	0.3	0.6	0.2
Qualifications: College or University degree	0.3	0.9	3.6	-0.4	-0.7	0.3	1.0	1.0	1.9	-0.2
Mean time to correctly identify matches	0.3	0.6	1.9	0.2	-0.6	0.6	-1.1	-0.7	-1.4	-0.2
Leg fat-free mass (right)	0.3	1.8	5.9	-1.1	-0.6	-2.4	-1.1	-1.5	-1.2	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.4	0.3	0.3	1.2	0.0	0.7	0.3	0.3
Medication: Gliclazide	0.3	0.3	0.7	0.8	-0.0	0.3	0.8	0.7	-0.3	-0.3
Leg predicted mass (right)	0.3	1.8	5.4	-1.1	-0.7	-2.3	-1.1	-1.5	-1.2	-0.6
Guilty feelings	0.3	0.4	0.8	0.7	0.9	0.2	0.7	0.3	0.6	0.8
Financial situation satisfaction	0.3	0.4	1.2	0.1	0.3	1.1	1.1	0.1	0.4	0.3
Ever smoked	0.3	0.6	2.1	1.5	0.7	-0.2	0.6	0.1	-0.6	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.1	-0.9	0.1	-0.8	-0.7	-0.9	-0.6
Pack years of smoking	0.3	0.4	1.0	-0.0	0.8	-1.0	-0.2	-0.6	-0.9	0.5
Impedance of whole body	0.3	1.5	4.6	2.1	0.9	0.9	0.9	1.6	0.3	0.9
Schizophrenia (2018)	0.2	0.3	1.0	-0.4	-0.3	-0.5	0.0	-0.3	-0.8	-1.0
Irritable Bowel Disease (IBD)	0.2	0.5	1.9	-0.2	0.4	1.4	0.2	-0.4	1.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	2.8	0.0	-0.0	-1.7	0.2	0.3	-0.0	-0.4
Blood Eosinophil Count	0.2	1.4	4.3	-1.8	0.5	-0.0	-0.4	-2.1	-1.4	-0.3
Heel T-Score	0.2	1.4	4.2	-0.1	-0.3	-0.9	-1.3	-1.6	-2.0	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.2	0.5	0.3	-1.5	0.0	-0.1	-0.9	-0.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.8	0.3	-0.4	0.2	0.6	0.3	0.1	0.9
Qualifications: CSEs or equivalent	0.2	0.3	0.7	-0.8	-0.7	-0.5	0.5	-0.1	0.7	-0.2
Medication: Levothyroxine sodium	0.2	0.3	1.3	-0.3	-0.3	0.1	0.4	0.2	0.4	-1.1
Mouth/teeth dental problems	0.2	0.4	0.6	-0.8	-0.7	0.0	0.6	0.6	0.7	0.5
Trunk fat-free mass	0.2	0.9	2.0	-1.2	-0.2	-1.4	-0.8	-1.4	-0.7	-0.3
Worrier / anxious feelings	0.2	0.4	2.1	0.4	0.6	1.5	0.4	0.1	-0.1	0.1
Happiness	0.2	0.3	0.8	-0.2	-0.1	0.8	-0.2	-0.6	-0.1	-0.9
Trunk predicted mass	0.2	0.9	2.0	-1.1	-0.1	-1.4	-0.8	-1.4	-0.7	-0.3
Arm fat-free mass (right)	0.2	1.0	5.4	0.1	0.8	-2.3	0.2	-0.4	-0.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.3	-0.8	0.8	-0.1	-0.1	0.0	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	0.1	-0.4	-0.0	0.8	0.2	-0.5	0.3
Arm predicted mass (right)	0.2	1.1	5.4	0.2	0.9	-2.3	0.1	-0.4	-0.6	0.8
Comparative height size at age 10	0.2	0.9	2.3	-0.3	-1.2	-1.5	-1.3	-0.7	-0.4	-0.2
Age at last live birth	0.2	0.3	0.9	-0.7	0.2	-0.2	0.1	-0.1	0.9	0.7
Whole body fat-free mass	0.2	1.3	4.3	-1.1	-0.2	-2.1	-0.9	-1.4	-1.0	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.1	0.5	0.6	-1.0	0.2	0.1	-0.3	0.4
Ever had bowel cancer screening	0.2	0.2	1.0	-0.3	-1.0	-0.0	-0.0	-0.2	0.6	-0.2
Friendships satisfaction	0.2	0.3	1.1	-0.2	-1.1	0.7	-0.3	0.3	0.1	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	-0.6	-0.9	-0.2	-0.5	-0.3	-0.1	-0.2
Whole body water mass	0.2	1.3	4.7	-1.0	-0.2	-2.2	-0.8	-1.4	-0.9	-0.2
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.6	-0.5	0.0	0.0	0.6	0.7	-0.2
Alcohol drinker status: Never	0.2	0.2	0.4	0.1	0.5	-0.6	-0.5	0.1	-0.5	0.2
Basal metabolic rate	0.2	1.2	6.0	-0.6	0.2	-2.4	-0.4	-0.9	-0.9	0.1
Arm fat-free mass (left)	0.2	1.1	5.7	-0.3	0.4	-2.4	-0.2	-0.9	-1.0	0.3
Supplements: Calcium	0.2	0.2	0.8	-0.1	-0.9	0.4	0.1	0.3	0.0	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	-0.4	-0.2	0.4	-0.6	-0.2	-0.5	-0.9
Arm predicted mass (left)	0.2	0.8	4.0	0.1	0.7	-2.0	0.0	-0.6	-0.8	0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.3	0.5	-0.4	0.0	0.3	-0.6	-0.4
Worry (Nagel 2018)	0.1	0.2	1.0	-0.1	-0.2	0.2	1.0	0.2	0.4	-0.1
Schizophrenia (2014)	0.1	0.3	0.6	-0.8	0.5	-0.6	0.0	0.3	0.0	-0.7
Blood Red Count	0.1	0.9	2.9	-1.2	-0.4	-0.2	1.2	0.3	1.7	0.1
Neuroticism	0.1	0.2	0.4	0.5	0.5	-0.5	0.6	-0.1	-0.7	-0.3
Hair Pigment	0.1	1.7	6.0	0.3	1.5	-0.5	2.5	1.9	0.3	0.0
Tanning	0.1	1.3	2.7	1.5	0.9	-1.0	-1.0	-0.6	-1.6	1.1
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.5	-0.2	0.3	-0.3	0.0	-0.2	-0.6
Angina	0.1	0.2	0.6	-0.6	-0.4	0.4	0.7	-0.1	0.2	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	0.1	-0.7	-0.4	0.3	-0.0	-0.4	-0.3
Stomach or abdominal pain in last month	0.1	0.2	0.6	-0.2	-0.8	-0.1	0.2	-0.4	0.6	-0.1
Alcohol usually taken with meals	0.1	0.2	0.5	-0.5	-0.5	0.0	-0.7	0.0	-0.5	-0.3
Hearing difficulty/problems with background noise	0.1	0.2	0.8	0.6	0.5	-0.9	0.1	0.2	0.0	-0.1
Forced vital capacity (FVC)	0.1	0.5	1.4	-1.2	-0.7	0.9	0.4	-0.5	0.4	0.1
Heart attack	0.1	0.2	0.6	-0.7	-0.3	0.6	0.4	-0.3	-0.0	-0.2
Impedance of arm (right)	0.1	0.7	1.4	0.3	-0.9	1.1	-1.0	-0.1	-0.5	-1.2
Impedance of arm (left)	0.1	0.3	1.1	1.0	-0.1	0.7	-0.2	0.6	-0.2	-0.3
Standing height	0.1	1.3	2.9	-1.1	-1.1	-0.6	-1.4	-1.7	-0.9	-0.8
Tense / ‘highly strung’	0.1	0.2	0.5	0.7	-0.3	0.2	0.6	0.4	-0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	-0.1	-0.3	-0.3	0.6	0.4	0.8	-0.8
High blood pressure (siblings)	0.1	0.2	0.9	0.2	-0.9	0.3	0.2	-0.2	-0.2	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	1.3	-0.4	-0.3	1.1	0.2	-0.1	0.4	0.8
Number of full brothers	0.1	0.2	1.1	-0.2	-0.0	1.0	-0.2	-0.2	-0.2	-0.0
Angina (self-reported)	0.1	0.2	0.3	-0.5	-0.5	0.3	0.6	-0.1	0.1	-0.4
Alcohol intake frequency.	0.1	0.3	0.9	0.4	0.3	-0.1	-0.7	-0.5	-1.0	0.3
Osteoporosis (self-reported)	0.1	0.1	0.4	0.1	0.1	0.6	-0.6	-0.2	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.7	-0.7	-0.8	0.6	-0.5	-0.3	-0.2	0.1
Fractured/broken bones in last 5 years	0.1	0.2	0.5	0.4	0.7	-0.0	-0.0	0.6	-0.2	0.5
Commuting to job workplace: Cycle	0.1	0.1	0.6	-0.5	-0.0	0.2	0.0	-0.1	0.7	-0.2
Pain experienced in last month	0.1	0.2	0.5	-0.1	0.7	0.5	0.0	0.3	0.7	-0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	-0.6	-0.1	0.5	0.6	-0.2	-0.0	-0.2
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	0.4	0.3	-0.1	0.0	0.3	0.2	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.4	1.2	-0.1	0.5	-0.4	-0.8	-1.1	-0.5	0.5
Height	0.0	0.5	1.1	1.1	0.3	0.7	-1.0	-0.7	-0.7	0.2
Sitting height	0.0	0.1	0.2	0.5	-0.0	-0.2	-0.1	0.0	-0.1	0.3
Headache pain in last month	0.0	0.0	0.1	0.0	0.1	0.3	0.1	0.0	0.2	0.3
Medication: Atorvastatin	0.0	0.0	0.2	0.1	0.0	0.3	0.2	0.0	-0.1	-0.4

Hub : Genes

ARHGEF18

Models

Trait associations