TWAS hub - ARHGEF2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0910	0.0490	0.0070	0.006	NA	0.004	NA	0.008	0.120	NA	0.1600	NA	0.084
2	GTEx	Ovary	0.6430	0.0940	0.0018	0.055	NA	0.127	NA	0.026	0.018	NA	0.0005	NA	0.075
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0663	0.0665	0.0048	0.005	0.014	0.019	NA	0.013	0.086	0.0098	0.0028	NA	0.011

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3
Crohns Disease (2012)	13.0	21.0	34.9	-5.3	-5.9
Birth weight	6.0	13.1	21.3	4.6	4.2
Crohns Disease (2017)	5.0	11.0	18.9	-3.7	-4.3
Breast Cancer	4.5	10.8	22.5	4.7	3.2
Heart disease (mother)	4.3	5.3	10.6	3.3	2.3
Irritable Bowel Disease (IBD)	4.1	9.8	17.8	-3.4	-4.2
Body Mass Index (BMI) (2010)	3.7	5.1	10.8	3.3	2.1
Allergy or Eczema	3.5	9.1	18.9	-4.3	-2.9
Comparative body size at age 10	3.1	8.4	14.0	3.4	3.7
Depression (Nagel 2018)	3.0	4.4	9.6	-3.1	-1.9
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.9	9.2	3.0	1.5
Guilty feelings	2.8	4.2	10.0	-3.2	-1.6
Bipolar Disorder or Schizophrenia	2.6	6.3	13.9	-2.2	-3.7
Mean Putamen Volume	2.6	3.0	6.7	-1.5	-2.6
Frequency of depressed mood in last 2 weeks	2.6	3.7	8.4	-2.9	-1.6
Number of children fathered	2.6	2.9	4.8	-2.2	-2.0
Reaction Time	2.4	4.6	7.7	-2.5	-2.8
Birth weight of first child	2.4	4.4	11.4	3.4	1.4
Chest pain or discomfort	2.4	3.4	6.0	-2.5	-2.1
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	6.5	-2.5	-1.7
Medication: Ibuprofen	2.3	2.7	6.4	2.5	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	4.5	-1.9	-2.1
Bipolar Disorder (2018)	2.2	3.5	6.1	-2.1	-2.5
Number of full brothers	2.2	2.8	5.3	-2.3	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	5.3	-2.3	-1.8
Ulcerative Colitis (UC)	2.1	4.0	6.7	-2.3	-2.6
Hayfever, allergic rhinitis or eczema	2.0	4.3	9.8	-3.1	-1.7
Tense / ‘highly strung’	2.0	3.3	7.2	-2.7	-1.6
Ever taken oral contraceptive pill	2.0	2.2	6.5	-0.4	-2.5
Myopia	2.0	2.9	6.1	-1.6	-2.5
Schizophrenia (2014)	1.9	4.1	9.7	-1.6	-3.1
Medication for hormone replacement therapy	1.8	2.0	5.2	-0.9	-2.3
Alzheimer’s Disease (in father)	1.7	1.8	3.0	1.7	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	3.9	-1.7	-2.0
Pain all over the body in last month	1.7	1.9	3.6	1.4	1.9
Medication: Ramipril	1.7	2.2	3.7	-1.9	-1.7
Mean time to correctly identify matches	1.7	3.3	5.4	-2.1	-2.3
Supplements: Vitamin C	1.7	2.0	4.1	1.4	2.0
LDL Cholesterol	1.6	2.6	6.5	-2.5	-1.1
High blood pressure (mother)	1.6	2.2	3.3	1.8	1.8
Illnesses of mother	1.6	2.0	4.2	-2.0	-1.3
Loneliness, isolation	1.6	2.2	5.5	-2.4	-1.0
Eye problems/disorders: Cataract	1.6	1.9	3.3	-1.5	-1.8
Commuting to job workplace: Public transport	1.6	1.9	4.2	2.1	1.3
Eye problems/disorders: Glaucoma	1.6	1.8	4.5	1.0	2.1
Schizophrenia (2018)	1.5	3.1	7.8	-1.2	-2.8
Relative age voice broke	1.5	2.3	3.7	-1.8	-1.9
Current tobacco smoking	1.4	2.3	6.2	-0.9	-2.5
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.3	1.4	1.5
Nervous feelings	1.3	2.3	5.1	2.3	1.4
Illnesses of father: None of the above (group 1)	1.3	1.6	2.4	-1.5	-1.5
Rheumatoid Arthritis	1.2	1.6	2.6	1.5	1.6
Allergy	1.2	2.8	6.4	2.5	1.5
Time employed in main current job	1.2	1.4	2.2	1.5	1.4
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	4.5	-2.1	-1.2
Ever depressed for a whole week	1.2	1.5	3.6	-0.9	-1.9
Lung FEV1/FVC ratio	1.1	5.3	15.6	-0.7	-4.0
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.9	-0.6	-2.0
Arm fat percentage (right)	1.1	4.5	13.5	3.7	0.2
Family relationship satisfaction	1.1	1.3	3.0	-1.7	-1.0
HDL Cholesterol	1.0	1.7	2.9	1.5	1.7
Hypothyroidism (self reported)	1.0	2.2	3.4	-1.8	-1.8
Respiratory disease	1.0	2.3	5.9	-1.0	-2.4
Sensitivity / hurt feelings	1.0	1.7	4.6	0.7	2.1
Severe depression (siblings)	1.0	1.1	3.1	-0.6	-1.8
Average weekly fortified wine intake	1.0	1.1	3.0	-0.6	-1.7
Worrier / anxious feelings	1.0	1.9	3.5	1.9	1.5
Arm fat percentage (left)	1.0	3.9	11.8	3.4	0.1
Breast cancer (self-reported)	1.0	1.2	3.4	-1.9	-0.3
Smoking status: Current	1.0	1.6	4.6	-0.3	-2.1
Medication: Lisinopril	1.0	1.3	2.1	1.4	1.3
Age started oral contraceptive pill	1.0	1.3	3.4	0.7	1.8
Impedance of leg (right)	0.9	4.3	8.0	-2.8	-2.2
Impedance of leg (left)	0.9	4.2	7.6	-2.8	-2.2
Pulse wave Arterial Stiffness index	0.9	1.0	1.9	-1.4	-1.1
Loud music exposure frequency	0.9	1.0	1.5	1.2	1.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.5	1.0	1.9
Gout (self-reported)	0.9	1.2	2.3	-1.1	-1.5
Wheeze or whistling in the chest in last year	0.9	1.6	2.9	-1.3	-1.7
Pulse wave peak to peak time	0.9	1.1	1.9	1.4	1.2
Risk taking	0.9	1.3	2.8	-1.7	-1.1
Pulse rate	0.8	1.3	3.2	-0.9	-1.8
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.1	-1.0	-1.4
Medication for pain relief, constipation, heartburn	0.8	1.4	4.0	-2.0	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.0	-1.7	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.9	1.7	0.1
Medication: Gliclazide	0.8	0.9	1.7	1.3	1.0
Heel T-Score	0.7	5.5	8.6	-2.8	-2.9
BMI	0.7	4.2	12.1	3.5	0.6
Hair Pigment	0.7	20.3	49.0	-7.0	-3.5
Trunk fat percentage	0.7	2.8	8.2	2.9	-0.6
Qualifications: CSEs or equivalent	0.7	0.9	1.6	-1.3	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.8	-1.7	-0.8
Hair/balding pattern: Pattern 2	0.7	0.8	2.4	-1.6	-0.3
Had other major operations	0.7	0.8	1.9	-0.7	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.1	-1.2	-1.8
Qualifications: None of the above	0.7	1.4	2.3	1.5	1.4
Lung cancer (father)	0.7	0.8	2.1	-0.6	-1.4
Arm fat mass (right)	0.7	2.8	8.5	2.9	0.2
Medication: Paracetamol	0.7	1.1	3.4	1.9	-0.0
Number of self-reported non-cancer illnesses	0.7	1.2	3.0	-0.8	-1.7
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.5	1.6	0.1
Pain experienced in last month	0.7	1.2	3.1	-1.8	-0.7
Heart disease (siblings)	0.7	0.8	1.9	0.7	1.4
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	-0.8	1.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	1.3	0.6
Trunk fat mass	0.6	2.5	7.2	2.7	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.3	-0.9	-1.5
Body fat percentage	0.6	2.3	6.6	2.6	-0.6
Age at first live birth	0.6	1.0	1.6	1.2	1.2
Eye problems/disorders: None of the above	0.6	0.7	1.4	1.2	0.8
Knee pain experienced in last month	0.6	0.9	2.7	-0.1	-1.6
Average weekly red wine intake	0.6	1.0	1.7	-1.1	-1.3
Arm fat mass (left)	0.6	2.6	7.7	2.8	0.1
Medication: Paracetamol	0.6	1.0	2.9	1.7	0.3
Medication: Atorvastatin	0.6	0.8	2.0	-1.4	-0.5
Fractured/broken bones in last 5 years	0.6	0.8	1.9	-0.7	-1.4
Unable to work because of sickness or disability	0.6	0.8	1.7	-0.8	-1.3
Alcohol drinker status: Previous	0.6	0.7	1.1	-1.1	-1.0
Depressed Affect (Nagel 2018)	0.5	1.1	3.1	-1.8	-0.4
Ulcerative Colitis	0.5	0.8	1.7	-0.8	-1.3
Lung FVC	0.5	2.6	5.4	2.3	1.5
Average weekly spirits intake	0.5	0.6	1.3	0.7	-1.1
Pack years adult smoking proportion	0.5	0.7	1.9	-0.5	-1.4
Fed-up feelings	0.5	0.8	1.4	-1.0	-1.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	1.0	-0.8
Financial difficulties in last 2 years	0.5	0.7	1.7	1.3	0.7
Father’s age at death	0.5	0.7	1.2	0.9	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.0	-0.8	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	-1.1	-0.8
Medication: Blood pressure	0.5	1.0	2.3	-0.8	-1.5
Whole body fat mass	0.5	2.1	6.1	2.5	-0.3
Alcohol intake frequency.	0.5	1.2	2.1	1.2	1.4
Mineral and other dietary supplements	0.5	0.6	1.2	1.1	0.8
Mother’s age at death	0.5	0.6	1.9	-0.1	1.4
HbA1C	0.4	0.4	0.9	1.0	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	-1.1	-0.6
Leg fat-free mass (left)	0.4	1.9	4.5	2.1	1.1
Body mass index (BMI)	0.4	1.7	5.1	2.2	0.1
Leg predicted mass (left)	0.4	2.2	4.9	2.2	1.2
Alcohol intake versus 10 years previously	0.4	0.5	1.4	-1.2	-0.5
Number of live births	0.4	0.6	1.6	-0.4	1.3
Depression (self-reported)	0.4	0.5	0.7	-0.9	-0.8
Medication: Lansoprazole	0.4	0.4	0.7	-0.8	-0.8
Length of working week for main job	0.4	0.4	1.0	-0.5	1.0
Breastfed as a baby	0.4	0.5	1.0	-1.0	0.8
Pulse wave reflection index	0.4	0.5	1.4	-1.2	-0.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	1.0	-0.7
Glaucoma (self-reported)	0.4	0.5	1.2	0.6	1.1
Exposure to tobacco smoke outside home	0.4	0.5	0.9	-0.8	-0.9
Worry too long after embarrassment	0.4	0.7	2.0	-1.4	0.1
Emphysema/chronic bronchitis	0.4	0.5	0.8	-0.9	-0.8
Comparative height size at age 10	0.4	2.1	3.7	1.6	1.9
Number of full sisters	0.4	0.5	1.5	-0.3	-1.2
Overall health rating	0.4	0.9	2.5	1.6	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.1	-0.5	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	-0.5	-1.0
Leg fat-free mass (right)	0.4	2.0	4.5	2.1	1.2
Commuting to job workplace: Walk	0.4	0.5	1.2	1.1	-0.5
Osteoarthritis (self-reported)	0.4	0.5	0.9	0.8	0.9
Leg predicted mass (right)	0.4	2.1	4.6	2.1	1.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	-0.7	-1.0
Commuting to job workplace: Cycle	0.4	0.4	1.3	-1.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.8	0.8	0.9
Pack years of smoking	0.4	0.5	1.4	-0.5	-1.2
Neuroticism (Nagel 2018)	0.3	0.6	1.6	-1.3	0.4
Alzheimer’s Disease (in mother)	0.3	0.4	1.1	0.0	-1.1
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.8	-0.6
Neuroticism (2016)	0.3	0.5	1.4	-1.2	0.1
Blood Eosinophil Count	0.3	1.9	3.4	1.9	1.6
Smoking Status	0.3	0.7	1.7	-0.6	-1.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.4	1.2	0.7
Maternal smoking around birth	0.3	0.4	1.1	1.1	-0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	-1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.1	-1.0	-0.9
Supplements: Glucosamine	0.3	0.4	1.3	-0.2	1.1
Number of incorrect matches in round	0.3	0.6	1.5	1.2	0.4
Had menopause	0.3	0.3	0.7	0.8	0.5
Diabetes (self-reported)	0.3	0.5	1.5	1.2	0.2
Medication: Simvastatin	0.3	0.4	1.1	1.1	0.4
Noisy workplace	0.3	0.4	1.1	-0.3	-1.0
Hair/balding pattern: Pattern 4	0.3	0.7	1.6	1.2	-0.7
Peak expiratory flow (PEF)	0.3	0.8	2.3	1.5	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.3	-0.3	-1.1
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	-0.3	-0.9
Neck or shoulder pain in last month	0.3	0.4	1.1	1.1	0.1
Leg fat mass (right)	0.3	1.1	2.6	1.6	-0.8
Age at last live birth	0.3	0.5	0.7	0.8	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	0.6	-0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	-0.5	-0.9
Diabetes diagnosed by doctor	0.3	0.6	1.7	1.3	0.1
Friendships satisfaction	0.3	0.3	0.7	-0.8	-0.6
Average weekly champagne plus white wine intake	0.3	0.4	1.1	1.1	0.3
Hearing aid user	0.3	0.3	0.9	0.2	1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	-1.1	-0.0
Alcohol drinker status: Never	0.3	0.3	1.0	-1.0	0.2
Irritability	0.3	0.5	0.7	-0.8	-0.9
Diastolic blood pressure, automated reading	0.3	0.9	1.7	1.0	1.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	0.9	0.5
Leg fat mass (left)	0.3	1.2	3.1	1.7	-0.6
Worry (Nagel 2018)	0.2	0.4	0.8	0.9	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.9	-0.0
Major Depression (MDD)	0.2	0.2	0.5	-0.4	-0.7
Ovarian Cancer	0.2	0.3	0.9	-0.1	1.0
Tanning	0.2	2.5	6.8	-2.6	-0.8
Hand grip strength (left)	0.2	0.4	0.9	-0.9	-0.6
Number of treatments/medications taken	0.2	0.3	0.8	0.3	-0.9
Stomach or abdominal pain in last month	0.2	0.2	0.6	0.3	-0.7
Fluid intelligence score	0.2	0.4	1.0	-1.0	-0.4
Weight	0.2	1.0	3.1	1.8	0.1
Impedance of arm (right)	0.2	1.1	3.2	1.8	0.4
Falls in the last year	0.2	0.3	0.9	-0.2	-1.0
Happiness	0.2	0.2	0.6	-0.8	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.2	-1.1	-0.0
Prospective memory result	0.2	0.2	0.5	0.7	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.8	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	-0.8	-0.6
Leg fat percentage (right)	0.2	0.8	1.6	1.0	-1.3
Medication: Omeprazole	0.2	0.2	0.6	0.4	0.8
Medication: Seretide 50 evohaler	0.2	0.3	0.6	0.5	0.7
Suffer from ‘nerves’	0.2	0.3	0.5	0.7	0.5
Leg pain on walking	0.2	0.3	0.6	0.8	0.4
Smoking status: Previous	0.2	0.2	0.7	-0.8	0.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.1	-0.7
Ever had bowel cancer screening	0.2	0.2	0.5	-0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.0	-0.8
Qualifications: nursing, teaching	0.2	0.4	0.9	-1.0	-0.4
Medication for cholesterol	0.2	0.3	0.5	0.7	0.6
Asthma (self-reported)	0.2	0.4	0.9	-0.6	-0.9
Osteoporosis (self-reported)	0.2	0.2	0.3	-0.5	0.6
Miserableness	0.2	0.3	0.8	-0.9	-0.4
Financial situation satisfaction	0.2	0.2	0.6	-0.8	-0.1
Medication: Blood pressure	0.2	0.3	0.8	-0.9	0.4
Medication: Bendroflumethiazide	0.2	0.4	1.1	0.2	1.0
Illnesses of father: High blood pressure	0.2	0.2	0.5	-0.3	-0.7
Leg fat percentage (left)	0.2	0.8	1.3	1.1	-1.1
Number of operations (self-reported)	0.2	0.3	0.6	-0.8	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.8	0.9	0.8
Supplements: Calcium	0.2	0.2	0.5	0.2	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	-0.8	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.7	0.3
Age at First Birth	0.1	0.1	0.4	-0.1	0.6
Coronary Artery Disease (CAD)	0.1	0.2	0.3	-0.6	0.4
Fasting Glucose	0.1	0.1	0.2	-0.0	0.5
Lupus	0.1	0.1	0.2	0.5	-0.3
Triglycerides	0.1	0.1	0.2	-0.5	-0.2
Blood Red Count	0.1	1.2	3.4	0.6	1.8
Height	0.1	1.5	4.5	-2.1	-0.1
Waist Hip Ratio (WHR)	0.1	0.4	1.2	-0.0	1.1
Systolic Blood Pressure	0.1	0.3	0.8	-0.2	0.9
Neuroticism	0.1	0.2	0.3	-0.6	0.5
Relative age of first facial hair	0.1	0.3	0.6	-0.8	-0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	0.3	-0.4
Vitamin and mineral supplements	0.1	0.2	0.3	-0.6	-0.5
Medication: Co-codamol	0.1	0.1	0.2	-0.2	-0.4
Medication: Metformin	0.1	0.1	0.3	0.5	-0.2
Diabetes (mother)	0.1	0.1	0.2	0.2	-0.4
Taking other prescription medications	0.1	0.2	0.5	0.1	-0.7
Age when periods started (menarche)	0.1	0.3	0.6	-0.6	-0.8
High blood pressure	0.1	0.1	0.3	-0.6	-0.3
Multivitamins +/- minerals	0.1	0.1	0.2	0.5	-0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.4	0.2
Waist circumference	0.1	0.3	1.0	1.0	-0.1
Past tobacco smoking	0.1	0.1	0.4	0.6	0.2
Alcohol usually taken with meals	0.1	0.2	0.5	-0.7	0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.7	-0.3
Forced vital capacity (FVC)	0.1	0.5	0.8	0.8	0.9
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.0	-0.4
Mouth/teeth dental problems	0.1	0.1	0.2	0.3	0.4
Illnesses of siblings	0.1	0.1	0.3	-0.1	0.6
Neuroticism score	0.1	0.2	0.6	-0.8	0.1
Hip circumference	0.1	0.2	0.5	0.7	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	0.4	0.7
Asthma	0.1	0.2	0.6	-0.3	-0.7
Medication: Cholesterol lowering	0.1	0.1	0.2	0.5	-0.4
Impedance of arm (left)	0.1	0.7	2.0	1.4	-0.1
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.6	0.3
Headache pain in last month	0.1	0.1	0.3	0.5	0.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	0.7	0.2
High blood pressure (siblings)	0.1	0.1	0.2	0.5	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.5	1.0	0.7	1.0
Health satisfaction	0.1	0.1	0.3	-0.0	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.3	0.6	0.1
Qualifications: College or University degree	0.1	0.2	0.5	-0.7	-0.3
Migraine (self-reported)	0.1	0.1	0.1	0.3	-0.4
Whole body fat-free mass	0.1	0.5	1.0	0.8	1.0
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.4	-0.5
Back pain experienced in last month	0.1	0.1	0.3	0.1	0.5
Whole body water mass	0.1	0.5	0.9	0.7	1.0
Wears glasses or contact lenses	0.1	0.2	0.5	0.7	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	-0.4	0.5
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.3	0.5
Basal metabolic rate	0.1	0.6	1.1	1.1	0.8
Average weekly beer plus cider intake	0.1	0.1	0.3	0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.5	-0.3
Impedance of whole body	0.1	0.4	0.9	-0.5	-1.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.1	-0.3
Prostate Cancer	0.0	0.0	0.1	-0.4	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.3	0.2
Blood Platelet Count	0.0	0.0	0.1	0.3	-0.0
Blood White Count	0.0	0.0	0.0	-0.0	0.1
Cardiovascular Disease	0.0	0.1	0.2	-0.2	-0.4
Chronotype (morning person)	0.0	0.0	0.1	-0.2	-0.2
Hearing difficulty/problems: Yes	0.0	0.1	0.1	-0.2	-0.4
Systolic blood pressure, automated reading	0.0	0.1	0.3	0.2	0.6
Angina	0.0	0.0	0.0	-0.0	-0.1
Supplements: Zinc	0.0	0.0	0.1	0.3	0.1
Diabetes (father)	0.0	0.0	0.0	0.2	-0.1
Hand grip strength (right)	0.0	0.0	0.1	-0.2	-0.3
Townsend deprivation index at recruitment	0.0	0.0	0.0	0.2	0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.2	0.0
Medication: Atenolol	0.0	0.1	0.1	-0.4	0.1
Medication: Levothyroxine sodium	0.0	0.0	0.1	-0.4	-0.0
Sitting height	0.0	0.2	0.4	-0.7	-0.3
Heart attack	0.0	0.0	0.1	-0.3	0.2
Trunk fat-free mass	0.0	0.2	0.5	-0.1	0.7
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.1	0.3	-0.1
Trunk predicted mass	0.0	0.2	0.5	-0.1	0.7
Standing height	0.0	0.2	0.6	-0.8	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.1	-0.1
Medication: Amlodipine	0.0	0.0	0.0	-0.2	0.0
Arm fat-free mass (right)	0.0	0.1	0.4	-0.6	0.1
Angina (self-reported)	0.0	0.0	0.0	0.2	-0.0
Medication: Allopurinol	0.0	0.1	0.1	-0.3	-0.3
Arm predicted mass (right)	0.0	0.1	0.4	-0.6	0.1
Pulse rate, automated reading	0.0	0.0	0.0	-0.0	0.1
Had major operations	0.0	0.0	0.0	0.1	-0.1
Medication: Aspirin	0.0	0.1	0.2	-0.1	-0.4
Hypertension (Self-reported)	0.0	0.1	0.3	-0.6	-0.1
Illnesses of father: Heart disease	0.0	0.0	0.1	0.1	0.3
Illnesses of siblings: Diabetes	0.0	0.0	0.0	0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.3	0.1
Mood swings	0.0	0.0	0.1	-0.0	-0.2
Medication: Aspirin	0.0	0.0	0.0	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	0.2	0.0
Ever smoked	0.0	0.1	0.2	-0.4	-0.3
Arm fat-free mass (left)	0.0	0.1	0.3	0.2	0.6
Cholesterol lowering medication	0.0	0.0	0.0	-0.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.3	0.3
Arm predicted mass (left)	0.0	0.2	0.5	0.1	0.7

Hub : Genes

ARHGEF2

Models

Trait associations