Hub : Genes

ARID4B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.199 0.055 8.6e-07 0.210 NA 0.118 NA 0.174 1.1e-09 NA 6.9e-06 NA 3.7e-08
2 TCGA Bladder Urothelial Carcinoma 0.053 0.027 1.8e-04 0.013 0.016 0.006 NA 0.010 2.7e-02 0.01600 9.0e-02 NA 4.5e-02
3 TCGA Rectum Adenocarcinoma 0.389 0.134 3.5e-04 0.005 0.049 0.026 NA 0.029 2.5e-01 0.02700 8.3e-02 NA 7.2e-02
4 TCGA Testicular Germ Cell Tumors 0.128 0.073 3.9e-04 -0.006 0.081 0.042 NA 0.028 6.4e-01 0.00082 1.3e-02 NA 3.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.0 0.0 0.1 -0.0 -0.3 -0.3 0.1
Bipolar Disorder or Schizophrenia 0.2 0.4 1.1 0.4 -1.0 -0.5 -0.2
Depressed Affect (Nagel 2018) 0.2 0.5 1.1 0.3 -0.9 -1.1 0.3
Depression (Nagel 2018) 1.2 1.8 4.5 0.3 -1.6 -2.1 0.3
Intelligence (Savage-Jansen 2018) 1.8 5.4 9.7 2.6 -0.2 2.3 -3.1
Neuroticism (Nagel 2018) 0.5 1.1 2.7 0.1 -1.2 -1.6 0.6
Schizophrenia (2018) 0.2 0.5 1.3 0.6 -1.1 -0.3 -0.4
Schizophrenia vs Biploar Disorder 0.8 1.0 1.8 -1.3 0.7 -0.5 1.3
Worry (Nagel 2018) 1.1 2.4 4.4 -1.1 -0.5 -2.1 1.9
Alzheimer’s Disease (in mother) 0.4 0.5 0.7 -0.8 0.7 0.2 0.8
Alzheimer’s Disease (in father) 1.7 1.8 2.5 1.6 0.1 1.5 -1.6
Alzheimer’s Disease (including proxy) 0.1 0.1 0.4 -0.2 0.4 0.6 0.1
Crohns Disease (2017) 0.8 1.8 3.2 0.9 -1.8 -1.7 -0.4
Irritable Bowel Disease (IBD) 0.4 1.0 1.4 1.2 -1.2 -0.6 -0.9
Ulcerative Colitis (UC) 0.2 0.4 0.7 0.8 -0.2 0.4 -0.8
Major Depression (MDD) 3.0 3.6 7.4 1.6 -2.7 -2.0 -0.8
Reaction Time 0.6 1.2 2.0 -0.9 1.4 1.2 0.5
Verbal and Numeric Reasoning (VNR) 1.2 2.9 4.6 1.7 0.4 2.1 -2.0
Breast Cancer 0.4 1.0 1.7 -1.1 1.3 0.6 0.9
Ovarian Cancer 0.9 1.3 2.0 -1.4 0.8 -0.7 1.4
Prostate Cancer 0.0 0.0 0.0 0.2 0.0 0.2 -0.2
Age at First Birth 1.7 2.4 4.2 -1.9 0.8 -1.2 2.1
Bipolar Disorder (2011) 0.8 0.8 1.7 -0.1 1.2 1.3 -0.3
Body Mass Index (BMI) (2010) 1.7 2.3 3.5 1.8 -1.5 0.1 -1.9
Coronary Artery Disease (CAD) 0.9 1.1 2.5 0.2 1.1 1.6 -0.7
Crohns Disease (2012) 1.0 1.6 2.7 1.3 -1.6 -0.9 -1.1
Mean Putamen Volume 0.7 0.8 1.4 -1.0 1.2 0.4 0.6
Fasting Glucose 0.6 0.8 1.5 1.2 -0.8 0.1 -1.0
HbA1C 1.2 1.4 2.1 -1.2 1.4 0.7 1.2
HDL Cholesterol 0.6 0.9 1.7 -1.0 0.2 -1.0 1.3
LDL Cholesterol 0.4 0.7 1.4 1.0 -0.6 0.5 -1.2
Lupus 6.3 9.6 15.4 3.9 -2.8 -0.0 -3.9
Neuroticism (2016) 1.4 2.0 3.8 1.7 -1.0 0.8 -1.9
Primary Biliary Cirrhosis 1.1 1.6 2.4 1.5 -1.2 0.5 -1.5
Rheumatoid Arthritis 1.3 1.8 3.7 -1.6 0.8 -0.4 1.9
Schizophrenia (2014) 0.2 0.4 1.0 -0.7 -0.1 -0.6 1.0
Triglycerides 0.0 0.0 0.1 -0.2 0.0 -0.0 0.1
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.1 0.2 -0.1 0.1 -0.4
Ulcerative Colitis 0.5 0.8 1.6 1.1 -0.5 0.3 -1.2
Blood Eosinophil Count 0.9 7.2 13.5 2.7 -3.7 -1.7 -2.2
Blood Platelet Count 1.4 16.6 29.2 4.4 -5.4 -2.3 -3.5
Blood Red Count 0.4 4.1 10.0 -1.8 3.2 1.6 0.9
Blood White Count 0.1 0.4 0.6 -0.7 0.2 -0.7 0.8
Heel T-Score 1.6 12.8 21.8 -4.6 2.2 -1.7 4.7
BMI 0.7 4.0 7.3 2.3 -1.7 -0.6 -2.7
Height 2.1 40.2 66.4 7.1 -0.5 6.6 -8.2
Waist Hip Ratio (WHR) 0.2 0.9 2.0 -0.8 1.4 0.4 0.8
Systolic Blood Pressure 0.3 1.5 2.9 1.5 -0.4 0.9 -1.7
Smoking Status 0.8 1.9 3.3 -1.8 0.7 -0.9 1.8
Allergy or Eczema 0.0 0.1 0.2 0.1 0.4 0.4 -0.1
Cardiovascular Disease 0.4 1.4 2.0 1.4 -1.4 -0.4 -1.2
Hypothyroidism (self reported) 6.4 14.7 25.7 4.8 -3.1 0.7 -5.1
Respiratory disease 1.6 3.6 5.4 2.3 -2.1 -0.3 -2.2
Type 2 Diabetes (T2D) (2018) 2.4 4.6 7.8 2.7 -0.6 1.7 -2.8
Lung FEV1/FVC ratio 0.8 3.9 7.5 -1.3 2.7 2.4 0.7
Lung FVC 0.0 0.1 0.3 -0.1 0.5 0.5 -0.1
Neuroticism 0.2 0.4 0.9 0.0 -0.4 -1.0 0.7
Chronotype (morning person) 0.1 0.3 0.7 0.7 -0.9 -0.2 -0.3
Hair Pigment 0.1 2.6 5.0 -1.5 2.2 1.3 1.2
Tanning 0.1 1.2 2.8 -0.1 -1.3 -1.7 0.5
Hand grip strength (left) 0.3 0.7 1.8 0.9 0.0 0.2 -1.3
Number of treatments/medications taken 1.2 2.1 3.4 1.7 -1.4 0.0 -1.8
Average weekly spirits intake 0.1 0.2 0.6 -0.0 0.3 0.0 -0.7
Sensitivity / hurt feelings 0.9 1.5 3.2 0.1 -1.6 -1.8 0.6
Frequency of depressed mood in last 2 weeks 0.8 1.2 2.4 0.5 -1.5 -1.4 0.1
Hearing difficulty/problems: Yes 0.2 0.3 0.4 -0.4 -0.2 -0.6 0.6
Relative age of first facial hair 1.6 3.2 6.4 -2.0 0.5 -1.5 2.5
Other serious medical condition/disability diagnosed by doctor 3.3 4.3 7.2 2.7 -1.8 0.1 -2.7
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.1 1.2 -0.4 0.5 -1.4
Ever had hysterectomy (womb removed) 1.0 1.1 1.7 1.3 -0.9 0.5 -1.3
Systolic blood pressure, automated reading 0.4 1.2 2.2 1.4 -0.8 0.1 -1.5
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.7 1.1 0.4 1.6 -1.3
Angina 0.0 0.1 0.1 0.1 -0.0 0.2 -0.4
Medication for hormone replacement therapy 1.1 1.2 2.0 1.4 -1.0 0.5 -1.3
Vitamin and mineral supplements 0.0 0.1 0.1 -0.2 0.4 -0.1 0.2
Supplements: Zinc 0.2 0.2 0.4 0.6 -0.1 0.2 -0.6
Medication: Co-codamol 0.0 0.0 0.1 0.0 -0.3 0.0 0.1
Medication: Metformin 1.0 1.5 2.5 1.6 -0.4 1.0 -1.5
Diabetes (father) 0.1 0.1 0.1 0.2 -0.0 0.3 -0.4
Diabetes (mother) 0.5 0.6 1.2 0.4 -0.9 -1.1 -0.5
Severe depression (siblings) 1.9 2.1 4.2 1.0 -2.0 -1.7 -0.7
Pack years adult smoking proportion 0.7 1.1 2.2 1.3 -0.6 -0.1 -1.5
Impedance of leg (right) 2.1 10.2 20.2 -3.7 2.6 0.4 4.5
Leg fat-free mass (left) 2.7 14.1 27.7 4.7 -2.4 0.9 -5.3
Trunk fat percentage 0.2 0.8 1.6 1.0 -0.6 -0.3 -1.3
Hand grip strength (right) 1.3 3.5 6.6 2.1 -0.0 1.6 -2.6
Townsend deprivation index at recruitment 2.2 3.1 5.3 -2.3 2.0 0.0 1.8
Current tobacco smoking 0.2 0.3 0.4 0.5 -0.7 -0.5 -0.6
Average weekly fortified wine intake 1.0 1.1 2.0 1.2 -1.1 -0.0 -1.4
Maternal smoking around birth 0.4 0.6 1.7 -0.4 -0.5 -1.3 0.7
Fed-up feelings 0.2 0.4 1.0 -0.4 0.1 -0.5 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.6 0.2 -1.3 -1.6 0.4
Relative age voice broke 0.3 0.5 0.9 -1.0 0.4 -0.3 0.9
Taking other prescription medications 0.7 1.1 1.8 1.3 -1.0 0.2 -1.3
Age when periods started (menarche) 0.2 0.5 0.9 0.0 -0.9 -0.6 0.8
Bilateral oophorectomy (both ovaries removed) 2.3 2.7 4.6 2.0 -1.1 0.8 -2.1
Heel bone mineral density (BMD) T-score, automated (left) 2.2 4.9 7.6 -2.7 2.8 0.5 2.1
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 1.2 1.1 -1.0 -0.5 -1.1
Qualifications: CSEs or equivalent 0.9 1.2 2.0 -1.4 0.7 -0.5 1.4
Serious illness, injury or assault to yourself 0.2 0.2 0.2 -0.5 0.4 -0.4 0.4
High blood pressure 0.5 1.5 2.8 1.5 -0.8 0.5 -1.7
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.0 0.1 -0.0 0.2 0.1
Multivitamins +/- minerals 0.2 0.2 0.4 -0.6 0.2 -0.2 0.6
Stomach or abdominal pain in last month 0.7 0.9 1.6 0.7 -1.3 -1.0 -0.5
Supplements: Glucosamine 1.7 2.2 4.0 1.7 -0.5 1.1 -2.0
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.0 0.8 -1.0 -0.3 -0.5
Medication: Atenolol 0.2 0.2 0.4 -0.6 0.1 -0.3 0.6
Medication: Levothyroxine sodium 6.3 10.6 19.0 4.1 -2.4 1.0 -4.4
Sitting height 1.4 9.9 15.3 3.0 0.7 3.9 -3.9
Chronic bronchitis/emphysema (father) 1.2 1.4 2.6 -1.6 0.9 -0.4 1.5
High blood pressure (mother) 1.6 2.3 4.6 0.7 -2.1 -2.0 -0.4
Body mass index (BMI) 0.6 2.7 3.3 1.4 -1.7 -1.8 -1.6
Impedance of leg (left) 1.6 7.5 14.6 -3.2 2.2 0.4 3.8
Leg predicted mass (left) 2.7 14.3 28.1 4.8 -2.4 0.9 -5.3
Trunk fat mass 0.7 3.2 6.8 2.2 -1.1 0.2 -2.6
Waist circumference 0.8 2.8 5.4 2.0 -1.2 -0.8 -2.3
Number of incorrect matches in round 4.8 7.9 13.1 -3.6 2.3 -0.7 3.6
Past tobacco smoking 0.7 1.2 2.5 1.3 -0.5 0.5 -1.6
Alcohol usually taken with meals 0.7 1.2 2.1 1.5 -1.0 0.5 -1.2
Nervous feelings 2.3 4.3 7.3 -1.8 -0.3 -2.5 2.7
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.2 0.5 0.2 -0.6 -0.7 0.1
Hearing difficulty/problems with background noise 1.6 2.6 3.6 1.9 -1.8 -0.3 -1.8
Hair/balding pattern: Pattern 2 2.3 3.0 5.0 -2.0 0.2 -1.7 2.2
Had menopause 3.0 3.7 4.9 2.2 -2.2 -0.8 -2.1
Had other major operations 0.8 1.0 1.4 1.2 -1.1 -0.6 -1.0
Forced vital capacity (FVC) 1.7 6.7 14.0 1.9 1.5 3.7 -2.6
Heel bone mineral density (BMD) T-score, automated (right) 3.1 7.0 10.8 -3.3 3.2 0.5 2.6
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.6 -1.0 -0.1 -1.2 1.3
Qualifications: None of the above 0.5 1.1 1.7 -1.3 1.3 0.2 1.1
Financial difficulties in last 2 years 3.2 4.3 6.7 -2.6 2.3 0.3 2.3
Mouth/teeth dental problems 0.7 1.0 1.7 -1.3 0.9 -0.2 1.3
Heart attack 0.3 0.4 0.8 0.1 -0.7 -0.9 0.4
Allergy 0.2 0.5 1.2 -0.5 1.1 0.7 0.2
Pain all over the body in last month 0.1 0.1 0.2 -0.4 0.3 -0.3 0.3
Diabetes (self-reported) 1.4 2.2 3.5 1.7 -0.1 1.5 -1.9
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 -0.5 0.4 0.1 0.9
Medication: Ramipril 0.1 0.1 0.3 -0.3 -0.3 -0.5 0.3
Medication: Simvastatin 2.3 3.3 5.9 2.2 -1.6 0.5 -2.4
Fluid intelligence score 0.8 1.7 2.6 1.6 -0.6 1.2 -1.6
Illnesses of siblings 0.1 0.1 0.2 -0.1 0.4 0.3 -0.2
Neuroticism score 0.5 1.1 2.4 -0.4 -0.6 -1.5 1.2
Weight 1.9 9.5 18.1 3.9 -2.2 0.1 -4.3
Impedance of arm (right) 0.7 3.5 4.3 -1.9 1.9 1.5 2.1
Arm fat percentage (right) 0.1 0.5 1.0 0.4 -0.5 -1.0 -0.8
Trunk fat-free mass 2.4 13.7 26.4 4.7 -2.3 1.1 -5.1
Hip circumference 1.2 5.1 9.3 2.7 -1.9 -0.5 -3.0
Time employed in main current job 0.7 0.8 1.5 0.8 -1.2 -0.7 -0.8
Alcohol intake versus 10 years previously 0.3 0.5 1.2 -0.6 -0.2 -0.7 1.1
Father’s age at death 0.7 0.9 2.5 -0.3 1.1 1.6 -0.0
Worrier / anxious feelings 0.7 1.3 2.1 1.4 -1.2 0.2 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.4 0.9 -1.2 -0.7 -0.7
Falls in the last year 0.1 0.2 0.5 0.1 -0.4 -0.7 0.2
Hair/balding pattern: Pattern 3 0.0 0.0 0.1 0.2 -0.0 0.3 -0.1
Number of live births 1.7 2.4 6.4 -0.3 -1.5 -2.5 0.8
Forced expiratory volume in 1-second (FEV1) 2.4 8.1 16.4 2.3 1.4 4.1 -3.0
Pulse rate 0.0 0.0 0.2 0.0 0.1 -0.4 -0.1
Happiness 0.8 1.0 2.1 -0.9 -0.4 -1.0 1.4
Noisy workplace 1.2 1.5 2.6 -1.1 1.6 1.1 1.0
Qualifications: A levels/AS levels or equivalent 0.9 2.1 5.3 1.0 0.6 2.3 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.5 -0.1 -0.4 -0.7 0.1
Mouth/teeth dental problems: Dentures 0.2 0.4 0.9 0.2 -0.8 -1.0 -0.2
Asthma 1.6 3.2 4.2 2.0 -2.0 -0.5 -2.0
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 0.3 -0.4 -0.5 -0.2
Medication: Cholesterol lowering 0.7 1.1 1.6 1.2 -1.0 0.4 -1.3
Depression (self-reported) 0.2 0.2 0.2 0.4 -0.4 -0.4 -0.4
Medication: Lansoprazole 2.0 2.3 4.6 1.0 1.0 2.1 -1.6
Prospective memory result 0.2 0.2 0.4 -0.6 0.4 -0.1 0.4
Lung cancer (father) 0.5 0.6 1.2 -0.3 1.1 1.0 -0.2
Illnesses of mother 0.8 0.9 2.1 0.2 1.2 1.5 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.3 15.5 1.3 1.9 3.9 -2.1
Pulse wave Arterial Stiffness index 0.5 0.6 1.1 1.1 -0.9 -0.3 -0.8
Impedance of arm (left) 0.5 2.5 3.5 -1.3 1.8 1.9 1.3
Arm fat mass (right) 0.8 3.3 5.5 2.0 -1.6 -1.0 -2.3
Trunk predicted mass 2.5 14.1 26.9 4.8 -2.3 1.1 -5.2
Standing height 2.3 23.0 39.3 5.8 -1.4 4.2 -6.3
Length of working week for main job 0.8 0.9 2.1 0.2 -1.2 -1.5 0.2
Exposure to tobacco smoke at home 0.1 0.1 0.2 0.5 -0.4 0.0 -0.4
Breastfed as a baby 1.0 1.3 3.9 0.4 0.7 2.0 -0.7
Tense / ‘highly strung’ 1.3 2.1 4.5 -1.2 -0.4 -2.1 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.5 6.8 0.1 -1.8 -2.6 0.5
Hair/balding pattern: Pattern 4 1.3 3.1 5.6 1.7 0.3 2.4 -1.9
Birth weight of first child 0.1 0.3 0.6 -0.1 0.6 0.8 -0.1
Peak expiratory flow (PEF) 3.6 8.3 14.8 2.7 1.0 3.9 -3.2
Pulse wave reflection index 0.1 0.1 0.3 0.2 -0.5 0.0 0.2
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 -0.0 0.1 0.3 -0.2
Loud music exposure frequency 0.1 0.1 0.3 0.1 0.2 0.2 0.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.1 -0.3 0.8 1.1 -0.0
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 2.6 0.9 -1.6 -1.3 -0.4
Blood clot in the leg (DVT) 0.5 0.6 0.9 -0.8 -0.3 -1.0 0.9
Medication: Paracetamol 0.1 0.1 0.3 -0.0 -0.5 -0.6 0.1
Headache pain in last month 0.0 0.0 0.1 0.2 -0.3 -0.1 0.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.1 -0.4 1.1 0.8 0.4
Glaucoma (self-reported) 0.1 0.1 0.3 0.1 -0.5 -0.5 0.1
Gout (self-reported) 0.2 0.3 0.6 0.5 -0.0 0.6 -0.8
Hypothyroidism/myxoedema (self-reported) 4.8 9.4 17.6 3.8 -2.1 1.1 -4.2
Medication: Amlodipine 2.4 3.3 5.7 1.6 -2.4 -1.7 -1.4
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.7 1.0 -1.3 -0.7 -0.6
Birth weight 1.5 3.3 7.4 1.2 1.1 2.7 -1.8
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.5 0.6 0.4 1.6 -0.8
High blood pressure (siblings) 0.4 0.6 1.3 -0.6 -0.3 -0.7 1.1
Forced vital capacity (FVC), Best measure 1.2 4.3 10.3 1.3 1.4 3.2 -1.8
Body fat percentage 0.1 0.3 0.8 0.2 -0.3 -0.9 -0.4
Leg fat percentage (right) 0.4 1.5 3.5 -1.1 0.1 -1.9 1.2
Arm fat-free mass (right) 2.5 12.7 24.4 4.5 -2.4 0.6 -4.9
Exposure to tobacco smoke outside home 2.7 3.6 6.1 -2.5 1.0 -1.4 2.3
Comparative body size at age 10 0.6 1.7 2.8 1.1 -1.7 -1.5 -0.7
Number of full brothers 0.0 0.1 0.1 0.1 -0.3 -0.3 0.1
Worry too long after embarrassment 0.1 0.2 0.3 0.2 -0.5 -0.6 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 0.1 -0.5 -0.9 0.1
Wheeze or whistling in the chest in last year 0.3 0.5 0.7 0.7 -0.8 -0.6 -0.7
Number of children fathered 0.1 0.1 0.3 -0.0 0.5 0.6 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.9 0.2 -1.0 -0.2 0.3
Age at first live birth 0.1 0.2 0.5 -0.4 0.7 0.3 0.4
Pulse wave peak to peak time 0.4 0.4 0.6 -0.7 0.8 0.6 0.4
Health satisfaction 0.1 0.2 0.4 -0.2 0.6 0.3 0.5
Shortness of breath walking on level ground 0.4 0.5 0.8 0.8 -0.4 0.4 -0.9
Qualifications: College or University degree 1.9 5.9 8.8 3.0 -2.1 1.2 -3.0
Eye problems/disorders: None of the above 0.1 0.1 0.1 -0.3 0.4 -0.3 0.3
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.9 1.0 -0.8 -0.1 -1.0
Emphysema/chronic bronchitis 0.7 0.8 1.5 1.2 -0.5 0.3 -1.2
Medication for pain relief, constipation, heartburn 0.5 0.9 1.6 0.9 0.0 1.3 -1.0
Neck or shoulder pain in last month 0.0 0.0 0.1 -0.0 0.2 0.3 0.2
Medication: Blood pressure 0.2 0.3 0.4 0.5 -0.7 -0.3 -0.6
Angina (self-reported) 0.0 0.0 0.0 -0.1 -0.1 -0.0 -0.1
Migraine (self-reported) 0.1 0.2 0.4 0.1 0.5 0.6 -0.0
Medication: Ibuprofen 0.1 0.2 0.3 0.4 0.1 0.3 -0.6
Medication: Allopurinol 0.1 0.1 0.4 0.1 0.3 0.6 -0.3
Medication: Omeprazole 1.3 1.5 2.1 1.4 -1.5 -1.0 -1.1
Medication: Seretide 50 evohaler 1.5 1.7 2.4 1.6 -1.5 -0.4 -1.4
Mean time to correctly identify matches 0.3 0.6 0.9 -0.6 0.9 0.9 0.3
Heart disease (mother) 0.5 0.7 1.2 -0.8 -0.3 -1.1 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.6 0.8 -0.3 0.7 -0.7
Whole body fat mass 0.6 2.3 4.4 1.8 -1.2 -0.5 -2.1
Leg fat mass (right) 0.3 1.3 1.5 1.1 -1.0 -1.2 -1.2
Arm predicted mass (right) 2.3 11.5 21.9 4.3 -2.3 0.5 -4.7
Pulse rate, automated reading 0.7 2.3 4.3 1.3 -2.1 -1.6 -0.7
Alcohol intake frequency. 0.2 0.4 0.6 0.8 -0.7 0.1 -0.7
Comparative height size at age 10 1.7 9.5 17.5 3.5 -0.3 2.9 -4.2
Number of full sisters 0.2 0.2 0.5 -0.7 0.5 0.1 0.4
Suffer from ‘nerves’ 2.8 4.4 9.2 -1.2 -1.1 -3.0 2.4
Overall health rating 0.7 1.5 2.7 1.1 -1.6 -1.3 -0.8
Chest pain or discomfort 0.6 0.9 2.5 -0.3 -0.6 -1.6 0.7
Had major operations 2.8 3.2 4.9 1.6 -2.2 -1.7 -1.5
Age at last live birth 0.3 0.4 0.7 -0.6 0.2 -0.6 0.8
Family relationship satisfaction 0.5 0.6 0.9 -0.9 0.9 0.1 0.9
Leg pain on walking 0.2 0.3 0.5 0.6 -0.7 -0.2 -0.2
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 3.6 -1.8 1.9 0.1 1.4
Commuting to job workplace: Car/motor vehicle 1.1 1.3 2.8 -0.8 -0.5 -1.7 1.2
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 2.4 1.5 -1.5 -0.8 -1.2
Medication: Aspirin 0.8 1.1 1.9 -1.1 0.1 -1.4 1.1
Supplements: Vitamin C 0.3 0.3 0.7 -0.5 0.5 0.1 0.9
Knee pain experienced in last month 0.1 0.2 0.4 0.7 -0.5 0.3 -0.3
Hypertension (Self-reported) 0.9 2.5 4.0 2.0 -1.5 0.2 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 1.8 1.4 -0.7 0.0 -1.3
Illnesses of father: Heart disease 0.2 0.2 0.4 -0.5 0.6 -0.2 0.5
Illnesses of siblings: Diabetes 0.5 0.6 1.1 0.9 -0.0 0.6 -1.1
Smoking status: Previous 1.0 1.5 3.3 -1.5 0.5 -0.6 1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 2.5 1.4 0.1 1.5 -1.6
Whole body fat-free mass 2.7 15.4 29.7 5.0 -2.6 0.9 -5.5
Leg fat-free mass (right) 3.3 17.9 35.2 5.3 -2.8 1.0 -5.9
Arm fat percentage (left) 0.2 0.7 1.2 0.7 -0.6 -1.0 -1.1
Average weekly red wine intake 0.0 0.0 0.1 -0.1 -0.3 -0.1 0.2
Handedness (chirality/laterality): Left-handed 2.3 2.7 4.5 -1.9 0.2 -1.7 2.1
Mood swings 1.0 1.8 4.2 -0.6 -1.0 -2.0 1.3
Loneliness, isolation 0.9 1.2 2.8 0.6 -1.7 -1.3 0.0
Long-standing illness, disability or infirmity 4.8 7.3 11.7 3.4 -2.4 -0.1 -3.4
Ever had bowel cancer screening 0.7 0.8 1.4 0.9 -1.2 -0.9 -0.6
Diabetes diagnosed by doctor 1.2 2.0 3.6 1.8 -0.4 1.0 -1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.5 0.7 0.1 0.4
Friendships satisfaction 1.9 2.3 4.2 -1.4 2.0 1.3 1.1
Qualifications: nursing, teaching 0.9 1.4 2.1 1.3 -0.0 1.4 -1.3
Commuting to job workplace: Walk 3.1 3.3 5.8 2.0 -0.5 1.8 -2.4
Eye problems/disorders: Cataract 1.0 1.2 1.9 -1.3 0.9 0.4 1.4
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.8 0.6 0.7 1.9 -0.7
Medication for cholesterol 2.2 3.3 5.7 -2.2 1.6 -0.5 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.1 -0.0 0.7 1.1 -0.3
Back pain experienced in last month 1.5 2.2 4.3 1.5 -2.1 -1.2 -0.9
Mineral and other dietary supplements 1.0 1.4 2.0 -1.4 1.2 0.2 1.4
Breast cancer (self-reported) 1.0 1.2 2.4 1.3 -1.6 -0.5 -0.7
Asthma (self-reported) 1.6 3.2 4.6 2.0 -2.1 -0.7 -1.9
Osteoporosis (self-reported) 0.0 0.0 0.0 0.1 0.1 -0.2 -0.1
Osteoarthritis (self-reported) 0.6 0.8 1.1 0.8 0.7 1.1 -1.0
Medication: Aspirin 0.3 0.5 1.1 -0.6 -0.2 -1.0 0.6
Medication: Gliclazide 2.3 2.6 3.8 1.9 -1.7 -0.6 -1.8
Illnesses of father: None of the above (group 1) 0.4 0.5 1.3 -0.4 -0.6 -1.2 0.5
Smoking status: Current 0.3 0.5 0.6 0.7 -0.8 -0.4 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.5 5.2 10.7 -2.0 3.3 2.0 1.4
Whole body water mass 2.7 15.6 30.1 5.0 -2.6 1.0 -5.5
Leg predicted mass (right) 3.3 17.6 34.3 5.2 -2.8 0.9 -5.9
Arm fat mass (left) 0.8 3.4 5.8 2.1 -1.6 -1.0 -2.4
Number of self-reported non-cancer illnesses 2.0 3.4 6.2 2.3 -1.5 0.3 -2.5
Average weekly champagne plus white wine intake 3.5 4.7 7.4 2.7 -2.1 0.4 -2.6
Miserableness 0.0 0.1 0.2 0.4 -0.2 0.2 -0.2
Guilty feelings 0.2 0.3 0.4 0.6 -0.7 -0.3 -0.4
Wears glasses or contact lenses 0.5 0.6 1.4 0.4 -1.2 -0.9 -0.2
Ever taken oral contraceptive pill 0.4 0.5 1.1 -0.7 0.1 -0.7 1.1
Hearing aid user 0.1 0.1 0.2 -0.1 -0.1 -0.4 0.3
Mother’s age at death 1.5 1.8 3.5 1.1 0.3 1.9 -1.6
Financial situation satisfaction 2.0 2.5 5.5 -1.5 0.3 -1.5 2.3
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.7 0.1 1.2 1.6 -0.5
Commuting to job workplace: Public transport 0.7 0.8 1.9 1.0 -0.4 0.6 -1.4
Eye problems/disorders: Glaucoma 1.3 1.5 2.7 1.2 -1.6 -1.1 -0.9
Medication: Blood pressure 1.4 2.7 4.6 2.0 -1.1 0.8 -2.2
Pain type(s) experienced in last month: Hip pain 3.0 3.7 6.2 2.5 -1.3 1.1 -2.4
Supplements: Fish oil (including cod liver oil) 0.0 0.0 0.1 -0.2 0.2 0.0 0.1
High cholesterol (Self-reported) 0.1 0.2 0.5 0.5 -0.4 0.2 -0.7
Medication: Bendroflumethiazide 1.0 1.6 2.7 1.2 -1.6 -1.0 -1.1
Medication: Paracetamol 0.4 0.6 1.2 0.8 -0.4 0.7 -1.1
Medication: Lisinopril 2.0 2.6 4.4 2.1 -1.6 0.4 -1.8
Medication: Atorvastatin 0.0 0.1 0.1 0.3 -0.4 -0.2 -0.1
Illnesses of father: High blood pressure 1.0 1.3 3.3 1.1 -1.8 -0.7 -0.3
Alcohol drinker status: Never 4.1 4.9 7.3 2.6 -2.7 -0.7 -2.3
Ever smoked 0.3 0.5 0.8 -0.8 -0.1 -0.8 0.9
Basal metabolic rate 2.6 14.3 27.2 4.8 -2.6 0.7 -5.2
Leg fat percentage (left) 0.3 1.1 3.4 -0.6 -0.2 -1.8 0.6
Arm fat-free mass (left) 1.9 9.7 17.8 3.9 -2.3 0.2 -4.2
Number of operations (self-reported) 2.2 3.2 5.2 2.3 -1.6 -0.3 -2.2
Average weekly beer plus cider intake 0.6 0.8 1.9 0.6 0.5 1.4 -0.9
Irritability 1.1 1.9 3.8 1.8 -0.8 0.4 -1.9
Risk taking 0.3 0.4 0.8 0.7 -0.3 0.3 -0.9
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.1 0.7 0.4 1.0 -0.5
Fractured/broken bones in last 5 years 4.3 5.5 7.8 2.8 -2.5 -0.7 -2.7
Age started oral contraceptive pill 0.7 0.9 1.4 1.2 -1.0 -0.0 -1.1
Diastolic blood pressure, automated reading 0.1 0.3 0.5 -0.6 0.5 -0.5 0.7
Ever depressed for a whole week 1.0 1.2 2.8 0.2 -1.4 -1.7 0.4
Unable to work because of sickness or disability 0.8 1.0 2.0 -0.8 1.4 1.1 0.3
Commuting to job workplace: Cycle 0.2 0.2 0.3 -0.3 0.6 0.6 0.3
Myopia 0.2 0.4 1.0 0.4 -1.0 -0.5 -0.3
Vascular/heart problems diagnosed by doctor 0.5 1.4 2.7 -1.4 0.8 -0.5 1.6
Cholesterol lowering medication 1.3 1.9 3.6 1.6 -1.1 0.2 -1.9
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 0.5 -0.5 -0.7 -0.1
Pain experienced in last month 1.1 1.8 2.8 -1.7 1.6 0.5 1.3
Supplements: Calcium 0.7 0.8 1.5 0.8 -1.2 -0.6 -0.8
Basal cell carcinoma (self-reported) 1.2 1.4 3.8 0.8 0.5 1.9 -1.0
Heart attack/myocardial infarction (self-reported) 0.4 0.6 1.3 0.1 -0.9 -1.1 0.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.9 -0.7 -0.6 -1.4 0.7
Heart disease (siblings) 0.8 1.0 1.4 1.1 -0.2 1.2 -1.1
Alcohol drinker status: Previous 0.2 0.2 0.6 -0.2 0.5 0.8 0.1
Pack years of smoking 1.0 1.4 2.7 1.5 -0.8 0.0 -1.6
Impedance of whole body 1.0 5.2 8.0 -2.5 2.2 1.3 2.8
Leg fat mass (left) 0.5 1.8 2.3 1.4 -1.2 -1.2 -1.5
Arm predicted mass (left) 1.7 8.9 17.0 3.8 -2.1 0.3 -4.1