Hub : Genes

ARID4B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.199	0.055	8.6e-07	0.210	NA	0.118	NA	0.174	1.1e-09	NA	6.9e-06	NA	3.7e-08
2	TCGA	Bladder Urothelial Carcinoma	0.053	0.027	1.8e-04	0.013	0.016	0.006	NA	0.010	2.7e-02	0.01600	9.0e-02	NA	4.5e-02
3	TCGA	Rectum Adenocarcinoma	0.389	0.134	3.5e-04	0.005	0.049	0.026	NA	0.029	2.5e-01	0.02700	8.3e-02	NA	7.2e-02
4	TCGA	Testicular Germ Cell Tumors	0.128	0.073	3.9e-04	-0.006	0.081	0.042	NA	0.028	6.4e-01	0.00082	1.3e-02	NA	3.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.0	0.0	0.1	-0.0	-0.3	-0.3	0.1
Bipolar Disorder or Schizophrenia	0.2	0.4	1.1	0.4	-1.0	-0.5	-0.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.1	0.3	-0.9	-1.1	0.3
Depression (Nagel 2018)	1.2	1.8	4.5	0.3	-1.6	-2.1	0.3
Intelligence (Savage-Jansen 2018)	1.8	5.4	9.7	2.6	-0.2	2.3	-3.1
Neuroticism (Nagel 2018)	0.5	1.1	2.7	0.1	-1.2	-1.6	0.6
Schizophrenia (2018)	0.2	0.5	1.3	0.6	-1.1	-0.3	-0.4
Schizophrenia vs Biploar Disorder	0.8	1.0	1.8	-1.3	0.7	-0.5	1.3
Worry (Nagel 2018)	1.1	2.4	4.4	-1.1	-0.5	-2.1	1.9
Alzheimer’s Disease (in mother)	0.4	0.5	0.7	-0.8	0.7	0.2	0.8
Alzheimer’s Disease (in father)	1.7	1.8	2.5	1.6	0.1	1.5	-1.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	-0.2	0.4	0.6	0.1
Crohns Disease (2017)	0.8	1.8	3.2	0.9	-1.8	-1.7	-0.4
Irritable Bowel Disease (IBD)	0.4	1.0	1.4	1.2	-1.2	-0.6	-0.9
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.8	-0.2	0.4	-0.8
Major Depression (MDD)	3.0	3.6	7.4	1.6	-2.7	-2.0	-0.8
Reaction Time	0.6	1.2	2.0	-0.9	1.4	1.2	0.5
Verbal and Numeric Reasoning (VNR)	1.2	2.9	4.6	1.7	0.4	2.1	-2.0
Breast Cancer	0.4	1.0	1.7	-1.1	1.3	0.6	0.9
Ovarian Cancer	0.9	1.3	2.0	-1.4	0.8	-0.7	1.4
Prostate Cancer	0.0	0.0	0.0	0.2	0.0	0.2	-0.2
Age at First Birth	1.7	2.4	4.2	-1.9	0.8	-1.2	2.1
Bipolar Disorder (2011)	0.8	0.8	1.7	-0.1	1.2	1.3	-0.3
Body Mass Index (BMI) (2010)	1.7	2.3	3.5	1.8	-1.5	0.1	-1.9
Coronary Artery Disease (CAD)	0.9	1.1	2.5	0.2	1.1	1.6	-0.7
Crohns Disease (2012)	1.0	1.6	2.7	1.3	-1.6	-0.9	-1.1
Mean Putamen Volume	0.7	0.8	1.4	-1.0	1.2	0.4	0.6
Fasting Glucose	0.6	0.8	1.5	1.2	-0.8	0.1	-1.0
HbA1C	1.2	1.4	2.1	-1.2	1.4	0.7	1.2
HDL Cholesterol	0.6	0.9	1.7	-1.0	0.2	-1.0	1.3
LDL Cholesterol	0.4	0.7	1.4	1.0	-0.6	0.5	-1.2
Lupus	6.3	9.6	15.4	3.9	-2.8	-0.0	-3.9
Neuroticism (2016)	1.4	2.0	3.8	1.7	-1.0	0.8	-1.9
Primary Biliary Cirrhosis	1.1	1.6	2.4	1.5	-1.2	0.5	-1.5
Rheumatoid Arthritis	1.3	1.8	3.7	-1.6	0.8	-0.4	1.9
Schizophrenia (2014)	0.2	0.4	1.0	-0.7	-0.1	-0.6	1.0
Triglycerides	0.0	0.0	0.1	-0.2	0.0	-0.0	0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.2	-0.1	0.1	-0.4
Ulcerative Colitis	0.5	0.8	1.6	1.1	-0.5	0.3	-1.2
Blood Eosinophil Count	0.9	7.2	13.5	2.7	-3.7	-1.7	-2.2
Blood Platelet Count	1.4	16.6	29.2	4.4	-5.4	-2.3	-3.5
Blood Red Count	0.4	4.1	10.0	-1.8	3.2	1.6	0.9
Blood White Count	0.1	0.4	0.6	-0.7	0.2	-0.7	0.8
Heel T-Score	1.6	12.8	21.8	-4.6	2.2	-1.7	4.7
BMI	0.7	4.0	7.3	2.3	-1.7	-0.6	-2.7
Height	2.1	40.2	66.4	7.1	-0.5	6.6	-8.2
Waist Hip Ratio (WHR)	0.2	0.9	2.0	-0.8	1.4	0.4	0.8
Systolic Blood Pressure	0.3	1.5	2.9	1.5	-0.4	0.9	-1.7
Smoking Status	0.8	1.9	3.3	-1.8	0.7	-0.9	1.8
Allergy or Eczema	0.0	0.1	0.2	0.1	0.4	0.4	-0.1
Cardiovascular Disease	0.4	1.4	2.0	1.4	-1.4	-0.4	-1.2
Hypothyroidism (self reported)	6.4	14.7	25.7	4.8	-3.1	0.7	-5.1
Respiratory disease	1.6	3.6	5.4	2.3	-2.1	-0.3	-2.2
Type 2 Diabetes (T2D) (2018)	2.4	4.6	7.8	2.7	-0.6	1.7	-2.8
Lung FEV1/FVC ratio	0.8	3.9	7.5	-1.3	2.7	2.4	0.7
Lung FVC	0.0	0.1	0.3	-0.1	0.5	0.5	-0.1
Neuroticism	0.2	0.4	0.9	0.0	-0.4	-1.0	0.7
Chronotype (morning person)	0.1	0.3	0.7	0.7	-0.9	-0.2	-0.3
Hair Pigment	0.1	2.6	5.0	-1.5	2.2	1.3	1.2
Tanning	0.1	1.2	2.8	-0.1	-1.3	-1.7	0.5
Hand grip strength (left)	0.3	0.7	1.8	0.9	0.0	0.2	-1.3
Number of treatments/medications taken	1.2	2.1	3.4	1.7	-1.4	0.0	-1.8
Average weekly spirits intake	0.1	0.2	0.6	-0.0	0.3	0.0	-0.7
Sensitivity / hurt feelings	0.9	1.5	3.2	0.1	-1.6	-1.8	0.6
Frequency of depressed mood in last 2 weeks	0.8	1.2	2.4	0.5	-1.5	-1.4	0.1
Hearing difficulty/problems: Yes	0.2	0.3	0.4	-0.4	-0.2	-0.6	0.6
Relative age of first facial hair	1.6	3.2	6.4	-2.0	0.5	-1.5	2.5
Other serious medical condition/disability diagnosed by doctor	3.3	4.3	7.2	2.7	-1.8	0.1	-2.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.1	1.2	-0.4	0.5	-1.4
Ever had hysterectomy (womb removed)	1.0	1.1	1.7	1.3	-0.9	0.5	-1.3
Systolic blood pressure, automated reading	0.4	1.2	2.2	1.4	-0.8	0.1	-1.5
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.7	1.1	0.4	1.6	-1.3
Angina	0.0	0.1	0.1	0.1	-0.0	0.2	-0.4
Medication for hormone replacement therapy	1.1	1.2	2.0	1.4	-1.0	0.5	-1.3
Vitamin and mineral supplements	0.0	0.1	0.1	-0.2	0.4	-0.1	0.2
Supplements: Zinc	0.2	0.2	0.4	0.6	-0.1	0.2	-0.6
Medication: Co-codamol	0.0	0.0	0.1	0.0	-0.3	0.0	0.1
Medication: Metformin	1.0	1.5	2.5	1.6	-0.4	1.0	-1.5
Diabetes (father)	0.1	0.1	0.1	0.2	-0.0	0.3	-0.4
Diabetes (mother)	0.5	0.6	1.2	0.4	-0.9	-1.1	-0.5
Severe depression (siblings)	1.9	2.1	4.2	1.0	-2.0	-1.7	-0.7
Pack years adult smoking proportion	0.7	1.1	2.2	1.3	-0.6	-0.1	-1.5
Impedance of leg (right)	2.1	10.2	20.2	-3.7	2.6	0.4	4.5
Leg fat-free mass (left)	2.7	14.1	27.7	4.7	-2.4	0.9	-5.3
Trunk fat percentage	0.2	0.8	1.6	1.0	-0.6	-0.3	-1.3
Hand grip strength (right)	1.3	3.5	6.6	2.1	-0.0	1.6	-2.6
Townsend deprivation index at recruitment	2.2	3.1	5.3	-2.3	2.0	0.0	1.8
Current tobacco smoking	0.2	0.3	0.4	0.5	-0.7	-0.5	-0.6
Average weekly fortified wine intake	1.0	1.1	2.0	1.2	-1.1	-0.0	-1.4
Maternal smoking around birth	0.4	0.6	1.7	-0.4	-0.5	-1.3	0.7
Fed-up feelings	0.2	0.4	1.0	-0.4	0.1	-0.5	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.6	0.2	-1.3	-1.6	0.4
Relative age voice broke	0.3	0.5	0.9	-1.0	0.4	-0.3	0.9
Taking other prescription medications	0.7	1.1	1.8	1.3	-1.0	0.2	-1.3
Age when periods started (menarche)	0.2	0.5	0.9	0.0	-0.9	-0.6	0.8
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	4.6	2.0	-1.1	0.8	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	2.2	4.9	7.6	-2.7	2.8	0.5	2.1
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.2	1.1	-1.0	-0.5	-1.1
Qualifications: CSEs or equivalent	0.9	1.2	2.0	-1.4	0.7	-0.5	1.4
Serious illness, injury or assault to yourself	0.2	0.2	0.2	-0.5	0.4	-0.4	0.4
High blood pressure	0.5	1.5	2.8	1.5	-0.8	0.5	-1.7
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.0	0.1	-0.0	0.2	0.1
Multivitamins +/- minerals	0.2	0.2	0.4	-0.6	0.2	-0.2	0.6
Stomach or abdominal pain in last month	0.7	0.9	1.6	0.7	-1.3	-1.0	-0.5
Supplements: Glucosamine	1.7	2.2	4.0	1.7	-0.5	1.1	-2.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	0.8	-1.0	-0.3	-0.5
Medication: Atenolol	0.2	0.2	0.4	-0.6	0.1	-0.3	0.6
Medication: Levothyroxine sodium	6.3	10.6	19.0	4.1	-2.4	1.0	-4.4
Sitting height	1.4	9.9	15.3	3.0	0.7	3.9	-3.9
Chronic bronchitis/emphysema (father)	1.2	1.4	2.6	-1.6	0.9	-0.4	1.5
High blood pressure (mother)	1.6	2.3	4.6	0.7	-2.1	-2.0	-0.4
Body mass index (BMI)	0.6	2.7	3.3	1.4	-1.7	-1.8	-1.6
Impedance of leg (left)	1.6	7.5	14.6	-3.2	2.2	0.4	3.8
Leg predicted mass (left)	2.7	14.3	28.1	4.8	-2.4	0.9	-5.3
Trunk fat mass	0.7	3.2	6.8	2.2	-1.1	0.2	-2.6
Waist circumference	0.8	2.8	5.4	2.0	-1.2	-0.8	-2.3
Number of incorrect matches in round	4.8	7.9	13.1	-3.6	2.3	-0.7	3.6
Past tobacco smoking	0.7	1.2	2.5	1.3	-0.5	0.5	-1.6
Alcohol usually taken with meals	0.7	1.2	2.1	1.5	-1.0	0.5	-1.2
Nervous feelings	2.3	4.3	7.3	-1.8	-0.3	-2.5	2.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	0.2	-0.6	-0.7	0.1
Hearing difficulty/problems with background noise	1.6	2.6	3.6	1.9	-1.8	-0.3	-1.8
Hair/balding pattern: Pattern 2	2.3	3.0	5.0	-2.0	0.2	-1.7	2.2
Had menopause	3.0	3.7	4.9	2.2	-2.2	-0.8	-2.1
Had other major operations	0.8	1.0	1.4	1.2	-1.1	-0.6	-1.0
Forced vital capacity (FVC)	1.7	6.7	14.0	1.9	1.5	3.7	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	3.1	7.0	10.8	-3.3	3.2	0.5	2.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.6	-1.0	-0.1	-1.2	1.3
Qualifications: None of the above	0.5	1.1	1.7	-1.3	1.3	0.2	1.1
Financial difficulties in last 2 years	3.2	4.3	6.7	-2.6	2.3	0.3	2.3
Mouth/teeth dental problems	0.7	1.0	1.7	-1.3	0.9	-0.2	1.3
Heart attack	0.3	0.4	0.8	0.1	-0.7	-0.9	0.4
Allergy	0.2	0.5	1.2	-0.5	1.1	0.7	0.2
Pain all over the body in last month	0.1	0.1	0.2	-0.4	0.3	-0.3	0.3
Diabetes (self-reported)	1.4	2.2	3.5	1.7	-0.1	1.5	-1.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.5	0.4	0.1	0.9
Medication: Ramipril	0.1	0.1	0.3	-0.3	-0.3	-0.5	0.3
Medication: Simvastatin	2.3	3.3	5.9	2.2	-1.6	0.5	-2.4
Fluid intelligence score	0.8	1.7	2.6	1.6	-0.6	1.2	-1.6
Illnesses of siblings	0.1	0.1	0.2	-0.1	0.4	0.3	-0.2
Neuroticism score	0.5	1.1	2.4	-0.4	-0.6	-1.5	1.2
Weight	1.9	9.5	18.1	3.9	-2.2	0.1	-4.3
Impedance of arm (right)	0.7	3.5	4.3	-1.9	1.9	1.5	2.1
Arm fat percentage (right)	0.1	0.5	1.0	0.4	-0.5	-1.0	-0.8
Trunk fat-free mass	2.4	13.7	26.4	4.7	-2.3	1.1	-5.1
Hip circumference	1.2	5.1	9.3	2.7	-1.9	-0.5	-3.0
Time employed in main current job	0.7	0.8	1.5	0.8	-1.2	-0.7	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.2	-0.6	-0.2	-0.7	1.1
Father’s age at death	0.7	0.9	2.5	-0.3	1.1	1.6	-0.0
Worrier / anxious feelings	0.7	1.3	2.1	1.4	-1.2	0.2	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.4	0.9	-1.2	-0.7	-0.7
Falls in the last year	0.1	0.2	0.5	0.1	-0.4	-0.7	0.2
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	0.2	-0.0	0.3	-0.1
Number of live births	1.7	2.4	6.4	-0.3	-1.5	-2.5	0.8
Forced expiratory volume in 1-second (FEV1)	2.4	8.1	16.4	2.3	1.4	4.1	-3.0
Pulse rate	0.0	0.0	0.2	0.0	0.1	-0.4	-0.1
Happiness	0.8	1.0	2.1	-0.9	-0.4	-1.0	1.4
Noisy workplace	1.2	1.5	2.6	-1.1	1.6	1.1	1.0
Qualifications: A levels/AS levels or equivalent	0.9	2.1	5.3	1.0	0.6	2.3	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	-0.1	-0.4	-0.7	0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	0.9	0.2	-0.8	-1.0	-0.2
Asthma	1.6	3.2	4.2	2.0	-2.0	-0.5	-2.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.3	-0.4	-0.5	-0.2
Medication: Cholesterol lowering	0.7	1.1	1.6	1.2	-1.0	0.4	-1.3
Depression (self-reported)	0.2	0.2	0.2	0.4	-0.4	-0.4	-0.4
Medication: Lansoprazole	2.0	2.3	4.6	1.0	1.0	2.1	-1.6
Prospective memory result	0.2	0.2	0.4	-0.6	0.4	-0.1	0.4
Lung cancer (father)	0.5	0.6	1.2	-0.3	1.1	1.0	-0.2
Illnesses of mother	0.8	0.9	2.1	0.2	1.2	1.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	15.5	1.3	1.9	3.9	-2.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.1	1.1	-0.9	-0.3	-0.8
Impedance of arm (left)	0.5	2.5	3.5	-1.3	1.8	1.9	1.3
Arm fat mass (right)	0.8	3.3	5.5	2.0	-1.6	-1.0	-2.3
Trunk predicted mass	2.5	14.1	26.9	4.8	-2.3	1.1	-5.2
Standing height	2.3	23.0	39.3	5.8	-1.4	4.2	-6.3
Length of working week for main job	0.8	0.9	2.1	0.2	-1.2	-1.5	0.2
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.5	-0.4	0.0	-0.4
Breastfed as a baby	1.0	1.3	3.9	0.4	0.7	2.0	-0.7
Tense / ‘highly strung’	1.3	2.1	4.5	-1.2	-0.4	-2.1	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.5	6.8	0.1	-1.8	-2.6	0.5
Hair/balding pattern: Pattern 4	1.3	3.1	5.6	1.7	0.3	2.4	-1.9
Birth weight of first child	0.1	0.3	0.6	-0.1	0.6	0.8	-0.1
Peak expiratory flow (PEF)	3.6	8.3	14.8	2.7	1.0	3.9	-3.2
Pulse wave reflection index	0.1	0.1	0.3	0.2	-0.5	0.0	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.0	0.1	0.3	-0.2
Loud music exposure frequency	0.1	0.1	0.3	0.1	0.2	0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.1	-0.3	0.8	1.1	-0.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.6	0.9	-1.6	-1.3	-0.4
Blood clot in the leg (DVT)	0.5	0.6	0.9	-0.8	-0.3	-1.0	0.9
Medication: Paracetamol	0.1	0.1	0.3	-0.0	-0.5	-0.6	0.1
Headache pain in last month	0.0	0.0	0.1	0.2	-0.3	-0.1	0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-0.4	1.1	0.8	0.4
Glaucoma (self-reported)	0.1	0.1	0.3	0.1	-0.5	-0.5	0.1
Gout (self-reported)	0.2	0.3	0.6	0.5	-0.0	0.6	-0.8
Hypothyroidism/myxoedema (self-reported)	4.8	9.4	17.6	3.8	-2.1	1.1	-4.2
Medication: Amlodipine	2.4	3.3	5.7	1.6	-2.4	-1.7	-1.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.7	1.0	-1.3	-0.7	-0.6
Birth weight	1.5	3.3	7.4	1.2	1.1	2.7	-1.8
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.5	0.6	0.4	1.6	-0.8
High blood pressure (siblings)	0.4	0.6	1.3	-0.6	-0.3	-0.7	1.1
Forced vital capacity (FVC), Best measure	1.2	4.3	10.3	1.3	1.4	3.2	-1.8
Body fat percentage	0.1	0.3	0.8	0.2	-0.3	-0.9	-0.4
Leg fat percentage (right)	0.4	1.5	3.5	-1.1	0.1	-1.9	1.2
Arm fat-free mass (right)	2.5	12.7	24.4	4.5	-2.4	0.6	-4.9
Exposure to tobacco smoke outside home	2.7	3.6	6.1	-2.5	1.0	-1.4	2.3
Comparative body size at age 10	0.6	1.7	2.8	1.1	-1.7	-1.5	-0.7
Number of full brothers	0.0	0.1	0.1	0.1	-0.3	-0.3	0.1
Worry too long after embarrassment	0.1	0.2	0.3	0.2	-0.5	-0.6	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.1	-0.5	-0.9	0.1
Wheeze or whistling in the chest in last year	0.3	0.5	0.7	0.7	-0.8	-0.6	-0.7
Number of children fathered	0.1	0.1	0.3	-0.0	0.5	0.6	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	0.2	-1.0	-0.2	0.3
Age at first live birth	0.1	0.2	0.5	-0.4	0.7	0.3	0.4
Pulse wave peak to peak time	0.4	0.4	0.6	-0.7	0.8	0.6	0.4
Health satisfaction	0.1	0.2	0.4	-0.2	0.6	0.3	0.5
Shortness of breath walking on level ground	0.4	0.5	0.8	0.8	-0.4	0.4	-0.9
Qualifications: College or University degree	1.9	5.9	8.8	3.0	-2.1	1.2	-3.0
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	0.4	-0.3	0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	1.0	-0.8	-0.1	-1.0
Emphysema/chronic bronchitis	0.7	0.8	1.5	1.2	-0.5	0.3	-1.2
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	0.9	0.0	1.3	-1.0
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.0	0.2	0.3	0.2
Medication: Blood pressure	0.2	0.3	0.4	0.5	-0.7	-0.3	-0.6
Angina (self-reported)	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1
Migraine (self-reported)	0.1	0.2	0.4	0.1	0.5	0.6	-0.0
Medication: Ibuprofen	0.1	0.2	0.3	0.4	0.1	0.3	-0.6
Medication: Allopurinol	0.1	0.1	0.4	0.1	0.3	0.6	-0.3
Medication: Omeprazole	1.3	1.5	2.1	1.4	-1.5	-1.0	-1.1
Medication: Seretide 50 evohaler	1.5	1.7	2.4	1.6	-1.5	-0.4	-1.4
Mean time to correctly identify matches	0.3	0.6	0.9	-0.6	0.9	0.9	0.3
Heart disease (mother)	0.5	0.7	1.2	-0.8	-0.3	-1.1	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.6	0.8	-0.3	0.7	-0.7
Whole body fat mass	0.6	2.3	4.4	1.8	-1.2	-0.5	-2.1
Leg fat mass (right)	0.3	1.3	1.5	1.1	-1.0	-1.2	-1.2
Arm predicted mass (right)	2.3	11.5	21.9	4.3	-2.3	0.5	-4.7
Pulse rate, automated reading	0.7	2.3	4.3	1.3	-2.1	-1.6	-0.7
Alcohol intake frequency.	0.2	0.4	0.6	0.8	-0.7	0.1	-0.7
Comparative height size at age 10	1.7	9.5	17.5	3.5	-0.3	2.9	-4.2
Number of full sisters	0.2	0.2	0.5	-0.7	0.5	0.1	0.4
Suffer from ‘nerves’	2.8	4.4	9.2	-1.2	-1.1	-3.0	2.4
Overall health rating	0.7	1.5	2.7	1.1	-1.6	-1.3	-0.8
Chest pain or discomfort	0.6	0.9	2.5	-0.3	-0.6	-1.6	0.7
Had major operations	2.8	3.2	4.9	1.6	-2.2	-1.7	-1.5
Age at last live birth	0.3	0.4	0.7	-0.6	0.2	-0.6	0.8
Family relationship satisfaction	0.5	0.6	0.9	-0.9	0.9	0.1	0.9
Leg pain on walking	0.2	0.3	0.5	0.6	-0.7	-0.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	3.6	-1.8	1.9	0.1	1.4
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.8	-0.8	-0.5	-1.7	1.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.4	1.5	-1.5	-0.8	-1.2
Medication: Aspirin	0.8	1.1	1.9	-1.1	0.1	-1.4	1.1
Supplements: Vitamin C	0.3	0.3	0.7	-0.5	0.5	0.1	0.9
Knee pain experienced in last month	0.1	0.2	0.4	0.7	-0.5	0.3	-0.3
Hypertension (Self-reported)	0.9	2.5	4.0	2.0	-1.5	0.2	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.8	1.4	-0.7	0.0	-1.3
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.5	0.6	-0.2	0.5
Illnesses of siblings: Diabetes	0.5	0.6	1.1	0.9	-0.0	0.6	-1.1
Smoking status: Previous	1.0	1.5	3.3	-1.5	0.5	-0.6	1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.5	1.4	0.1	1.5	-1.6
Whole body fat-free mass	2.7	15.4	29.7	5.0	-2.6	0.9	-5.5
Leg fat-free mass (right)	3.3	17.9	35.2	5.3	-2.8	1.0	-5.9
Arm fat percentage (left)	0.2	0.7	1.2	0.7	-0.6	-1.0	-1.1
Average weekly red wine intake	0.0	0.0	0.1	-0.1	-0.3	-0.1	0.2
Handedness (chirality/laterality): Left-handed	2.3	2.7	4.5	-1.9	0.2	-1.7	2.1
Mood swings	1.0	1.8	4.2	-0.6	-1.0	-2.0	1.3
Loneliness, isolation	0.9	1.2	2.8	0.6	-1.7	-1.3	0.0
Long-standing illness, disability or infirmity	4.8	7.3	11.7	3.4	-2.4	-0.1	-3.4
Ever had bowel cancer screening	0.7	0.8	1.4	0.9	-1.2	-0.9	-0.6
Diabetes diagnosed by doctor	1.2	2.0	3.6	1.8	-0.4	1.0	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.5	0.7	0.1	0.4
Friendships satisfaction	1.9	2.3	4.2	-1.4	2.0	1.3	1.1
Qualifications: nursing, teaching	0.9	1.4	2.1	1.3	-0.0	1.4	-1.3
Commuting to job workplace: Walk	3.1	3.3	5.8	2.0	-0.5	1.8	-2.4
Eye problems/disorders: Cataract	1.0	1.2	1.9	-1.3	0.9	0.4	1.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.8	0.6	0.7	1.9	-0.7
Medication for cholesterol	2.2	3.3	5.7	-2.2	1.6	-0.5	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.1	-0.0	0.7	1.1	-0.3
Back pain experienced in last month	1.5	2.2	4.3	1.5	-2.1	-1.2	-0.9
Mineral and other dietary supplements	1.0	1.4	2.0	-1.4	1.2	0.2	1.4
Breast cancer (self-reported)	1.0	1.2	2.4	1.3	-1.6	-0.5	-0.7
Asthma (self-reported)	1.6	3.2	4.6	2.0	-2.1	-0.7	-1.9
Osteoporosis (self-reported)	0.0	0.0	0.0	0.1	0.1	-0.2	-0.1
Osteoarthritis (self-reported)	0.6	0.8	1.1	0.8	0.7	1.1	-1.0
Medication: Aspirin	0.3	0.5	1.1	-0.6	-0.2	-1.0	0.6
Medication: Gliclazide	2.3	2.6	3.8	1.9	-1.7	-0.6	-1.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	-0.4	-0.6	-1.2	0.5
Smoking status: Current	0.3	0.5	0.6	0.7	-0.8	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.2	10.7	-2.0	3.3	2.0	1.4
Whole body water mass	2.7	15.6	30.1	5.0	-2.6	1.0	-5.5
Leg predicted mass (right)	3.3	17.6	34.3	5.2	-2.8	0.9	-5.9
Arm fat mass (left)	0.8	3.4	5.8	2.1	-1.6	-1.0	-2.4
Number of self-reported non-cancer illnesses	2.0	3.4	6.2	2.3	-1.5	0.3	-2.5
Average weekly champagne plus white wine intake	3.5	4.7	7.4	2.7	-2.1	0.4	-2.6
Miserableness	0.0	0.1	0.2	0.4	-0.2	0.2	-0.2
Guilty feelings	0.2	0.3	0.4	0.6	-0.7	-0.3	-0.4
Wears glasses or contact lenses	0.5	0.6	1.4	0.4	-1.2	-0.9	-0.2
Ever taken oral contraceptive pill	0.4	0.5	1.1	-0.7	0.1	-0.7	1.1
Hearing aid user	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.3
Mother’s age at death	1.5	1.8	3.5	1.1	0.3	1.9	-1.6
Financial situation satisfaction	2.0	2.5	5.5	-1.5	0.3	-1.5	2.3
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.7	0.1	1.2	1.6	-0.5
Commuting to job workplace: Public transport	0.7	0.8	1.9	1.0	-0.4	0.6	-1.4
Eye problems/disorders: Glaucoma	1.3	1.5	2.7	1.2	-1.6	-1.1	-0.9
Medication: Blood pressure	1.4	2.7	4.6	2.0	-1.1	0.8	-2.2
Pain type(s) experienced in last month: Hip pain	3.0	3.7	6.2	2.5	-1.3	1.1	-2.4
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	-0.2	0.2	0.0	0.1
High cholesterol (Self-reported)	0.1	0.2	0.5	0.5	-0.4	0.2	-0.7
Medication: Bendroflumethiazide	1.0	1.6	2.7	1.2	-1.6	-1.0	-1.1
Medication: Paracetamol	0.4	0.6	1.2	0.8	-0.4	0.7	-1.1
Medication: Lisinopril	2.0	2.6	4.4	2.1	-1.6	0.4	-1.8
Medication: Atorvastatin	0.0	0.1	0.1	0.3	-0.4	-0.2	-0.1
Illnesses of father: High blood pressure	1.0	1.3	3.3	1.1	-1.8	-0.7	-0.3
Alcohol drinker status: Never	4.1	4.9	7.3	2.6	-2.7	-0.7	-2.3
Ever smoked	0.3	0.5	0.8	-0.8	-0.1	-0.8	0.9
Basal metabolic rate	2.6	14.3	27.2	4.8	-2.6	0.7	-5.2
Leg fat percentage (left)	0.3	1.1	3.4	-0.6	-0.2	-1.8	0.6
Arm fat-free mass (left)	1.9	9.7	17.8	3.9	-2.3	0.2	-4.2
Number of operations (self-reported)	2.2	3.2	5.2	2.3	-1.6	-0.3	-2.2
Average weekly beer plus cider intake	0.6	0.8	1.9	0.6	0.5	1.4	-0.9
Irritability	1.1	1.9	3.8	1.8	-0.8	0.4	-1.9
Risk taking	0.3	0.4	0.8	0.7	-0.3	0.3	-0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	0.7	0.4	1.0	-0.5
Fractured/broken bones in last 5 years	4.3	5.5	7.8	2.8	-2.5	-0.7	-2.7
Age started oral contraceptive pill	0.7	0.9	1.4	1.2	-1.0	-0.0	-1.1
Diastolic blood pressure, automated reading	0.1	0.3	0.5	-0.6	0.5	-0.5	0.7
Ever depressed for a whole week	1.0	1.2	2.8	0.2	-1.4	-1.7	0.4
Unable to work because of sickness or disability	0.8	1.0	2.0	-0.8	1.4	1.1	0.3
Commuting to job workplace: Cycle	0.2	0.2	0.3	-0.3	0.6	0.6	0.3
Myopia	0.2	0.4	1.0	0.4	-1.0	-0.5	-0.3
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.7	-1.4	0.8	-0.5	1.6
Cholesterol lowering medication	1.3	1.9	3.6	1.6	-1.1	0.2	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.5	-0.5	-0.7	-0.1
Pain experienced in last month	1.1	1.8	2.8	-1.7	1.6	0.5	1.3
Supplements: Calcium	0.7	0.8	1.5	0.8	-1.2	-0.6	-0.8
Basal cell carcinoma (self-reported)	1.2	1.4	3.8	0.8	0.5	1.9	-1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.3	0.1	-0.9	-1.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.9	-0.7	-0.6	-1.4	0.7
Heart disease (siblings)	0.8	1.0	1.4	1.1	-0.2	1.2	-1.1
Alcohol drinker status: Previous	0.2	0.2	0.6	-0.2	0.5	0.8	0.1
Pack years of smoking	1.0	1.4	2.7	1.5	-0.8	0.0	-1.6
Impedance of whole body	1.0	5.2	8.0	-2.5	2.2	1.3	2.8
Leg fat mass (left)	0.5	1.8	2.3	1.4	-1.2	-1.2	-1.5
Arm predicted mass (left)	1.7	8.9	17.0	3.8	-2.1	0.3	-4.1