Hub : Genes

ARNT2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1140	0.0330	2.7e-04	0.035	0.031	0.033	0.034	0.037	3.5e-05	9.8e-05	5.5e-05	4.3e-05	2.0e-05
2	GTEx	Adipose Visceral Omentum	0.2360	0.0800	4.2e-03	0.001	NA	0.002	NA	0.002	2.7e-01	NA	2.5e-01	NA	2.3e-01
3	GTEx	Artery Aorta	0.2300	0.0640	4.7e-04	0.143	NA	0.149	NA	0.192	2.8e-08	NA	1.4e-08	NA	7.7e-11
4	GTEx	Artery Tibial	0.2788	0.0601	2.6e-05	0.144	NA	0.097	NA	0.142	2.2e-11	NA	5.2e-08	NA	3.1e-11
5	GTEx	Esophagus Muscularis	0.1850	0.0680	5.1e-03	-0.005	NA	0.000	NA	0.003	9.3e-01	NA	3.4e-01	NA	2.1e-01
6	GTEx	Heart Atrial Appendage	0.4350	0.0880	1.0e-04	0.225	NA	0.234	NA	0.272	1.8e-10	NA	7.3e-11	NA	1.3e-12
7	GTEx	Nerve Tibial	0.1470	0.0502	3.1e-03	0.031	NA	0.045	NA	0.059	3.0e-03	NA	4.0e-04	NA	5.4e-05
8	TCGA	Brain Lower Grade Glioma	0.0599	0.0259	1.5e-03	0.027	0.025	0.012	NA	0.021	4.0e-04	6.2e-04	1.3e-02	NA	1.7e-03
9	TCGA	Prostate Adenocarcinoma	0.1404	0.0655	6.1e-03	0.048	0.011	0.050	NA	0.037	8.4e-06	2.0e-02	5.3e-06	NA	9.4e-05
10	TCGA	Testicular Germ Cell Tumors	0.2220	0.0790	1.7e-03	0.083	0.090	0.104	NA	0.090	7.3e-04	4.3e-04	1.6e-04	NA	4.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.2	1.9	6.4	2.2	-0.1	-1.0	-1.1	1.3	1.4	0.6	1.1	-0.2	2.5
Bipolar Disorder or Schizophrenia	0.4	0.9	2.6	1.3	-1.6	0.2	0.0	0.2	0.6	0.5	0.8	-1.2	1.3
Depressed Affect (Nagel 2018)	0.6	1.2	3.7	-1.0	-1.9	0.1	1.0	0.9	-1.1	0.7	-0.8	1.2	-1.3
Depression (Nagel 2018)	0.7	1.0	4.0	-0.3	-1.8	-0.3	1.2	0.2	-0.5	2.0	0.0	-0.5	0.5
Intelligence (Savage-Jansen 2018)	1.6	4.8	10.8	0.2	-1.7	-2.5	-1.8	0.8	1.1	-3.1	-3.3	-2.0	-3.0
Neuroticism (Nagel 2018)	0.7	1.6	5.5	-2.3	-1.4	-0.0	1.8	0.4	-1.7	-0.0	-1.0	0.6	-1.0
Schizophrenia (2018)	0.4	0.9	4.1	-0.1	-2.0	1.1	1.0	-0.8	-0.4	0.2	0.2	-1.3	-0.4
Schizophrenia vs Biploar Disorder	0.6	0.7	2.8	0.5	-1.1	0.7	0.6	-1.7	-0.8	0.0	1.1	-0.3	0.5
Worry (Nagel 2018)	1.2	2.6	12.4	-3.5	0.1	-0.3	0.9	0.0	-2.0	-0.9	-1.9	-1.1	-1.6
Alzheimer’s Disease (in mother)	0.3	0.3	1.2	0.5	0.4	0.0	-0.7	-0.6	0.5	0.7	1.1	0.1	-0.0
Alzheimer’s Disease (in father)	1.6	1.8	5.3	2.0	-1.9	-0.7	-1.1	-0.3	-0.5	-2.3	1.5	0.8	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	4.8	2.2	-0.1	-0.1	-0.8	-0.7	0.6	-0.9	1.3	0.7	0.3
Crohns Disease (2017)	1.9	4.2	8.5	-1.1	2.9	1.1	2.5	-2.0	2.0	2.2	2.3	-0.1	2.5
Irritable Bowel Disease (IBD)	1.6	3.7	8.3	-2.2	2.6	1.3	2.9	-0.9	2.1	2.7	1.0	0.1	1.2
Ulcerative Colitis (UC)	0.8	1.6	4.5	-2.1	1.2	0.5	1.4	0.7	1.9	1.6	-0.9	0.0	-0.3
Major Depression (MDD)	0.3	0.4	2.8	-0.2	0.2	-0.3	0.6	0.4	-0.3	0.6	-0.3	-1.7	-0.3
Reaction Time	1.0	2.0	8.2	-1.5	-1.5	-1.4	-0.9	-0.9	-0.6	-1.5	-1.0	-0.1	-2.9
Verbal and Numeric Reasoning (VNR)	0.8	2.0	4.9	1.0	-0.8	-1.4	-1.9	-0.0	0.4	-2.2	-1.7	-2.0	-0.5
Breast Cancer	0.2	0.6	1.9	-0.6	-0.7	0.5	-0.1	-1.4	0.3	0.3	-1.3	-0.8	-0.5
Ovarian Cancer	0.9	1.1	4.9	-0.4	0.5	-2.2	-1.1	-0.6	1.5	-0.7	-1.1	-0.4	-0.5
Prostate Cancer	1.8	2.6	5.3	-2.3	-1.9	-1.1	-0.3	0.2	0.4	-1.3	-2.0	-2.3	-2.2
Age at First Birth	0.5	0.8	2.0	-1.3	0.9	-1.4	-1.4	0.6	-0.5	-0.7	0.1	0.0	-0.5
Bipolar Disorder (2011)	2.6	2.5	9.5	3.1	-0.6	-1.9	-2.4	0.2	1.3	0.8	0.8	-0.8	1.3
Body Mass Index (BMI) (2010)	0.5	0.7	2.4	0.4	-0.4	0.4	1.1	-0.4	1.1	1.6	1.1	-0.1	0.7
Coronary Artery Disease (CAD)	1.5	1.7	5.7	0.5	0.5	0.4	2.4	-1.5	1.4	1.1	1.3	1.6	1.2
Crohns Disease (2012)	2.0	3.2	10.0	-0.0	3.2	2.0	2.0	-1.7	1.4	1.8	1.6	0.8	1.8
Mean Putamen Volume	1.2	1.4	3.0	-1.6	-1.2	1.7	1.4	1.3	-0.2	0.3	-1.2	-0.9	-0.6
Fasting Glucose	1.5	1.8	7.4	-2.0	0.7	0.8	2.7	-0.9	-0.6	-1.2	-0.5	1.6	-0.5
HbA1C	1.7	1.8	4.9	-2.0	1.8	0.6	2.2	0.4	0.7	1.8	-1.1	0.9	-0.3
HDL Cholesterol	1.0	1.6	4.8	1.2	-2.2	-1.0	-1.5	0.7	-0.2	-1.0	1.2	0.4	1.9
LDL Cholesterol	0.7	1.1	4.8	-1.0	0.3	0.7	1.1	1.4	-0.1	0.2	-2.2	0.1	-1.1
Lupus	0.6	0.9	3.7	-0.4	-1.9	1.2	0.5	-0.0	-1.0	0.2	0.9	1.1	0.8
Neuroticism (2016)	0.2	0.3	0.6	0.2	-0.5	-0.2	0.3	0.8	0.8	0.8	-0.1	0.6	0.5
Primary Biliary Cirrhosis	0.4	0.6	1.6	-0.4	0.1	0.4	0.8	0.6	0.7	1.0	1.3	-0.6	1.3
Rheumatoid Arthritis	1.1	1.5	4.0	-0.9	1.9	0.8	2.0	0.3	-0.8	1.3	1.2	1.1	0.7
Schizophrenia (2014)	0.3	0.6	3.2	1.0	-1.8	-0.0	0.0	-0.5	0.5	-0.0	0.3	-0.9	0.2
Triglycerides	0.3	0.5	1.4	-0.6	0.2	0.4	1.1	-1.1	0.3	-0.5	-0.3	-1.2	0.1
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.7	1.9	-1.1	1.4	0.1	-0.1	0.5	-1.8	-1.9	-0.8	-0.6
Ulcerative Colitis	0.9	1.3	3.2	-1.8	1.5	0.8	1.8	0.7	0.8	1.1	-0.9	-0.2	0.6
Blood Eosinophil Count	0.5	3.6	9.3	-2.4	-2.2	-3.0	-1.6	0.5	-1.5	0.4	-2.3	-1.4	-2.1
Blood Platelet Count	0.1	0.8	3.1	-0.7	0.4	1.8	1.5	-0.3	-0.3	-0.2	-1.2	0.4	0.2
Blood Red Count	1.0	9.3	44.2	1.2	-0.2	-6.7	-5.5	-0.6	-1.0	-2.8	-0.7	0.7	-2.8
Blood White Count	0.2	1.6	3.7	-1.9	0.7	0.7	0.5	1.9	-1.1	1.9	-0.9	1.2	-0.4
Heel T-Score	0.3	2.4	8.0	-0.3	-2.8	0.6	1.1	-0.4	0.8	-2.8	-2.2	-0.2	-1.3
BMI	0.7	4.0	14.5	0.2	-0.2	1.1	3.0	2.7	0.9	3.8	1.1	-1.2	2.0
Height	0.1	1.6	8.3	0.9	1.8	0.6	0.0	-2.9	1.4	-0.8	0.1	-0.7	-0.5
Waist Hip Ratio (WHR)	0.4	1.9	4.6	-2.1	1.8	0.9	2.0	0.2	-0.3	1.9	-0.9	0.4	-1.1
Systolic Blood Pressure	0.3	1.4	5.5	0.9	-1.1	0.1	0.3	-0.8	1.2	2.4	1.3	-0.9	1.2
Smoking Status	1.6	3.8	15.1	1.0	2.4	1.3	1.5	0.8	1.8	3.9	1.4	-1.1	2.3
Allergy or Eczema	1.0	2.7	8.9	-1.9	-0.4	-1.1	-0.9	0.9	-1.7	-1.3	-2.2	-1.3	-3.0
Cardiovascular Disease	0.7	2.3	14.4	0.9	-0.7	0.0	1.7	-0.1	1.1	3.8	1.1	-0.3	1.3
Hypothyroidism (self reported)	0.4	0.8	3.3	1.8	-0.3	0.3	1.0	-1.2	0.8	-0.5	-0.3	-1.2	0.3
Respiratory disease	0.2	0.5	1.3	-0.8	0.6	-0.1	-0.2	-1.1	-0.9	-0.7	-0.4	-1.0	-0.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	5.7	0.2	-1.0	0.1	0.3	2.4	0.1	-0.4	-1.3	-0.8	-0.3
Lung FEV1/FVC ratio	0.1	0.3	1.0	0.8	-1.0	0.3	-0.7	0.2	0.5	0.2	0.2	-0.1	0.8
Lung FVC	0.5	2.6	7.7	2.8	-0.6	-2.0	-1.9	-0.5	0.2	-1.6	2.6	0.8	0.5
Neuroticism	0.6	1.5	5.1	-2.3	-0.6	1.1	1.6	0.2	-1.5	-0.2	-1.1	1.1	-1.0
Chronotype (morning person)	0.7	1.6	5.4	-2.3	2.3	0.8	0.8	0.6	-1.1	-0.2	-1.6	-0.5	-0.1
Hair Pigment	0.1	1.5	4.1	1.5	1.0	1.6	2.0	0.2	-0.1	-0.8	0.1	1.6	1.5
Tanning	0.1	1.1	3.5	-1.3	0.2	1.1	1.7	0.1	0.1	1.1	-1.9	-0.4	-0.1
Hand grip strength (left)	0.8	2.1	6.2	2.3	0.8	-0.2	-1.1	-0.9	2.0	-0.2	2.5	0.5	1.5
Number of treatments/medications taken	0.3	0.5	2.3	-0.5	1.0	0.5	1.5	-0.4	0.4	0.7	-0.1	0.7	-0.4
Average weekly spirits intake	0.2	0.2	1.1	-0.0	1.0	0.4	0.2	0.1	0.4	0.1	0.7	0.4	0.0
Sensitivity / hurt feelings	1.1	1.8	7.0	-1.1	-1.1	1.1	2.7	1.5	1.3	0.2	-1.8	0.0	-0.4
Frequency of depressed mood in last 2 weeks	1.2	1.7	6.9	-1.3	-0.9	1.4	1.6	-0.4	-0.3	2.6	0.5	-1.2	1.0
Hearing difficulty/problems: Yes	0.9	1.4	4.6	-2.2	-0.7	-0.1	0.3	1.7	-2.1	0.1	-0.0	-1.4	-0.1
Relative age of first facial hair	0.2	0.4	1.3	0.4	-0.0	0.7	-0.1	-0.9	-0.9	-1.1	0.1	-0.1	-0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.7	-0.4	0.3	0.0	0.6	0.9	1.3	1.1	0.3	1.1	1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.1	1.1	0.6	-0.0	-0.1	0.6	-0.8	-0.5	-1.8	-0.3	-1.7
Ever had hysterectomy (womb removed)	1.2	1.4	4.7	-1.4	-0.1	1.5	0.7	-0.8	1.2	-0.9	-1.3	-0.2	-2.2
Systolic blood pressure, automated reading	0.3	1.0	6.4	0.3	1.0	-0.2	0.9	-0.7	0.9	2.5	0.5	0.2	0.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	4.9	2.2	-0.5	-0.5	-0.0	-0.5	-0.1	-1.0	0.1	-0.5	1.8
Angina	0.8	1.1	4.0	1.4	1.2	-0.4	-2.0	-0.7	0.3	-1.2	0.8	-0.4	0.3
Medication for hormone replacement therapy	0.5	0.6	1.6	1.3	-0.6	0.4	-0.4	0.3	0.8	-1.1	-1.0	-0.3	-0.7
Vitamin and mineral supplements	0.9	1.2	3.9	0.6	0.7	-2.0	-1.8	0.4	-0.0	0.1	-0.7	-1.6	-0.8
Supplements: Zinc	2.0	2.1	7.7	-0.3	-2.8	1.9	2.1	-0.2	1.3	-0.4	-1.3	0.7	-1.2
Medication: Co-codamol	0.9	1.1	6.8	0.2	-0.3	0.8	0.4	0.9	0.6	1.0	0.7	0.3	2.6
Medication: Metformin	0.8	1.2	4.8	0.6	-1.4	-0.8	-0.7	0.6	1.0	-0.5	-1.0	-2.2	-0.8
Diabetes (father)	1.1	1.3	4.3	-0.6	-1.6	0.4	2.0	0.0	2.1	-0.8	-1.2	0.1	-0.1
Diabetes (mother)	0.7	0.9	3.1	1.0	-0.9	-0.5	-0.9	1.0	1.8	0.4	-1.1	-0.2	-0.2
Severe depression (siblings)	0.7	0.8	1.9	-1.0	0.4	1.4	1.1	0.4	0.2	1.1	0.9	-0.6	0.8
Pack years adult smoking proportion	1.2	1.8	5.9	0.2	-0.3	1.4	0.7	2.4	-1.1	1.5	0.2	2.1	1.4
Impedance of leg (right)	0.3	1.6	6.1	-1.0	-0.4	0.2	-0.4	1.4	-0.1	-0.5	-1.6	2.0	-2.5
Leg fat-free mass (left)	0.4	2.2	5.3	0.4	-0.1	1.3	1.1	-0.5	1.5	2.3	1.3	-2.1	2.3
Trunk fat percentage	0.7	3.0	14.7	0.3	-0.5	1.0	2.4	1.1	2.1	3.8	1.0	0.3	0.9
Hand grip strength (right)	0.4	1.0	2.5	1.2	0.8	0.1	-1.1	-0.8	1.6	-0.4	1.4	0.1	1.0
Townsend deprivation index at recruitment	1.9	2.7	8.1	-1.6	-0.5	2.9	2.1	-0.5	0.5	2.2	1.3	1.9	0.9
Current tobacco smoking	2.7	4.4	22.0	1.1	1.3	1.8	1.7	1.5	1.1	4.7	1.4	0.8	2.6
Average weekly fortified wine intake	0.6	0.7	2.5	-0.2	0.5	-0.2	-0.3	-0.6	0.5	-0.5	-1.6	-1.0	-1.3
Maternal smoking around birth	0.8	1.2	2.3	-1.2	0.3	1.5	1.5	0.1	1.5	1.5	-1.0	0.4	0.5
Fed-up feelings	0.8	1.5	4.4	-1.0	-0.1	0.6	1.6	0.7	-0.0	1.3	-2.1	0.6	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	4.8	0.5	-2.0	1.5	2.2	-0.1	-0.3	1.4	0.5	0.8	1.1
Relative age voice broke	0.6	0.8	2.3	0.8	0.9	-0.1	-1.5	0.3	-1.2	-1.5	0.7	0.3	-0.5
Taking other prescription medications	0.6	0.9	4.4	-0.2	0.3	-1.0	0.4	-2.1	0.1	0.3	0.1	-1.0	-1.5
Age when periods started (menarche)	0.6	1.4	6.6	1.1	0.8	-0.2	0.1	-0.7	0.4	0.8	1.8	0.8	2.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.5	0.0	-1.3	-0.4	-1.4	-1.0	-0.6	-0.1	0.4	1.1	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.9	-0.2	-0.7	1.2	2.4	-0.9	1.8	0.0	-1.3	-1.3	-0.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	4.3	0.0	-2.1	-1.0	-0.6	-0.1	-0.2	1.1	0.9	-0.2	0.3
Qualifications: CSEs or equivalent	0.7	1.0	3.8	-0.4	-1.3	0.5	0.8	-0.8	0.9	1.9	0.3	-0.9	1.0
Serious illness, injury or assault to yourself	2.1	2.5	7.4	-2.1	2.2	2.4	2.7	0.6	0.7	0.2	-0.9	0.9	0.3
High blood pressure	0.8	2.2	11.6	1.1	-0.7	-0.8	0.6	-0.1	1.0	3.4	2.2	0.3	1.3
Hayfever, allergic rhinitis or eczema	0.9	2.1	6.7	-1.2	-1.3	-1.3	-0.9	0.4	-1.3	-0.9	-1.6	-1.7	-2.6
Multivitamins +/- minerals	0.6	0.8	3.8	0.1	-1.0	0.8	1.5	-0.2	0.4	-0.3	0.7	-0.1	1.9
Stomach or abdominal pain in last month	0.8	1.0	3.7	-1.9	-1.1	0.9	1.3	0.8	-1.2	0.2	0.3	-0.1	-0.1
Supplements: Glucosamine	0.8	1.0	3.3	1.8	1.1	1.3	0.7	0.1	0.5	-0.4	0.6	1.1	1.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	6.3	-2.5	-1.1	1.3	0.2	1.0	-0.7	0.7	0.1	-0.9	-0.0
Medication: Atenolol	0.6	0.7	2.2	-0.7	-1.3	0.4	1.0	-0.2	1.5	0.8	0.7	0.8	-0.2
Medication: Levothyroxine sodium	0.2	0.4	1.6	1.3	-0.7	-0.0	0.1	-1.1	0.1	-0.5	0.1	-0.2	-0.3
Sitting height	0.1	1.0	3.2	1.4	0.5	0.8	-0.6	-1.4	1.8	-0.0	-0.6	-0.8	0.3
Chronic bronchitis/emphysema (father)	0.7	0.8	5.0	0.9	-0.5	0.7	0.4	0.6	-2.2	0.4	0.6	0.4	0.8
High blood pressure (mother)	0.5	0.7	2.3	-0.9	-0.0	-0.7	-0.0	-0.5	-0.2	1.3	0.5	-1.5	0.9
Body mass index (BMI)	0.6	2.4	10.8	0.2	-0.4	0.9	2.0	1.4	1.1	3.3	1.1	-0.9	1.8
Impedance of leg (left)	0.2	1.2	4.9	-0.9	0.3	-0.0	0.0	0.4	0.3	-0.6	-1.4	1.8	-2.2
Leg predicted mass (left)	0.4	2.2	5.4	0.4	0.0	1.3	1.1	-0.5	1.4	2.3	1.3	-2.0	2.2
Trunk fat mass	0.7	3.2	17.0	0.1	-0.4	1.4	2.4	0.8	1.9	4.1	1.1	-0.5	1.1
Waist circumference	0.7	2.7	12.0	-0.5	-0.6	1.3	2.4	1.0	1.3	3.5	0.6	-1.1	1.6
Number of incorrect matches in round	1.0	1.6	5.8	0.5	-0.9	-0.4	1.3	-1.9	-0.6	1.2	2.4	1.5	0.3
Past tobacco smoking	0.8	1.6	8.6	-1.0	-2.9	-0.4	-0.5	0.9	-0.9	-1.1	-1.1	0.2	-1.3
Alcohol usually taken with meals	0.6	1.0	3.1	0.4	-0.2	-1.8	-1.2	0.9	0.2	-0.1	1.1	1.6	0.1
Nervous feelings	0.9	1.8	5.0	-2.2	0.1	-0.0	1.3	0.9	-1.1	-1.4	-2.2	-0.5	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.4	-0.3	-1.2	1.6	1.0	-1.0	0.0	1.4	1.3	-0.4	0.9
Hearing difficulty/problems with background noise	0.7	1.2	3.4	-1.6	-0.7	0.4	0.5	1.8	-1.8	0.5	-0.4	-1.2	-0.5
Hair/balding pattern: Pattern 2	1.6	2.0	10.1	1.1	0.2	1.1	-0.3	-1.0	3.2	1.5	1.0	0.7	1.6
Had menopause	1.2	1.5	3.6	1.8	1.0	-0.0	0.5	-0.0	-1.4	-0.0	1.4	1.9	1.7
Had other major operations	0.9	1.1	4.2	-0.3	0.1	-0.1	-1.0	-0.2	0.4	-1.0	-2.0	-1.8	-1.0
Forced vital capacity (FVC)	0.3	1.1	5.4	0.9	-0.0	0.8	-0.5	-1.3	0.9	0.8	2.3	-0.4	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.7	-0.6	-1.7	0.8	1.1	-0.6	1.5	-1.1	-1.2	-1.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	4.7	-1.2	-2.2	0.1	0.3	0.5	0.2	0.5	-0.5	-0.8	-0.5
Qualifications: None of the above	0.3	0.7	3.5	1.2	-0.0	0.2	0.9	-0.1	0.9	0.8	0.4	1.9	-0.1
Financial difficulties in last 2 years	0.9	1.2	3.9	0.3	-1.5	-0.3	-0.4	0.5	0.6	1.7	1.5	-0.1	2.0
Mouth/teeth dental problems	0.4	0.6	2.3	-0.3	-0.3	0.8	1.0	0.4	1.5	1.0	-0.1	-0.1	0.4
Heart attack	0.2	0.2	0.7	0.1	0.9	0.3	0.2	-0.2	0.7	-0.3	-0.3	-0.5	0.4
Allergy	0.4	0.9	4.4	0.6	1.1	0.5	0.4	0.6	0.9	0.8	0.9	-0.0	2.1
Pain all over the body in last month	1.3	1.4	4.9	-2.2	0.7	1.4	1.0	-0.6	0.3	1.7	0.8	0.2	1.2
Diabetes (self-reported)	0.4	0.6	2.9	-0.0	-0.6	-0.1	-0.8	0.6	0.3	-1.7	-1.0	-0.3	-0.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.7	-0.5	1.3	-1.4	-1.3	-0.9	-0.8	-1.5	-0.9	-0.1	-1.7
Medication: Ramipril	1.0	1.2	3.4	-0.8	-1.3	1.0	1.8	1.1	0.9	1.3	-1.3	0.5	-0.3
Medication: Simvastatin	0.5	0.7	2.2	1.3	0.6	0.1	0.7	0.3	0.8	1.5	0.7	-0.8	0.5
Fluid intelligence score	1.6	3.4	7.8	2.1	-0.7	-2.8	-2.7	-0.3	0.2	-2.5	-1.0	-2.4	-0.5
Illnesses of siblings	0.5	0.6	2.2	0.1	-0.3	-0.9	-0.6	-0.2	0.4	-1.5	-0.9	1.1	-0.8
Neuroticism score	0.5	1.1	2.0	-1.4	-1.2	1.0	1.4	0.4	-0.8	0.2	-1.2	1.2	-0.7
Weight	0.6	2.8	12.6	-0.0	-0.3	1.5	2.0	0.3	1.6	3.5	1.2	-1.5	1.8
Impedance of arm (right)	0.3	1.5	7.2	-1.0	-2.0	0.0	-0.1	0.1	0.2	-0.6	-0.2	2.7	-1.5
Arm fat percentage (right)	0.7	2.9	14.5	-0.1	-1.0	1.0	2.3	1.5	1.3	3.8	1.1	-0.0	1.4
Trunk fat-free mass	0.3	1.6	5.8	0.0	0.5	1.3	0.8	-1.1	0.6	1.6	1.1	-2.4	1.6
Hip circumference	0.7	3.0	8.9	0.6	-1.3	1.6	2.0	1.3	2.1	3.0	0.3	-1.2	2.1
Time employed in main current job	0.6	0.7	3.7	0.0	-0.4	-0.2	1.1	-1.9	0.3	-0.2	-0.9	-1.1	-0.5
Alcohol intake versus 10 years previously	0.5	0.7	4.3	-1.1	0.0	2.1	0.9	0.1	0.1	0.7	-0.4	0.3	-0.4
Father’s age at death	0.8	1.0	2.5	-0.7	1.4	0.4	-0.4	-1.2	-1.3	1.6	0.4	0.1	1.3
Worrier / anxious feelings	0.7	1.4	6.3	-2.5	0.3	-0.2	0.8	-0.0	-2.0	-0.1	-1.3	0.8	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.9	-1.7	0.5	1.2	1.6	-0.2	-0.8	0.5	0.3	0.1	0.5
Falls in the last year	0.7	0.9	3.0	0.8	0.8	1.2	0.1	-0.0	-0.7	1.4	1.7	-0.4	0.8
Hair/balding pattern: Pattern 3	0.4	0.5	2.7	0.7	-1.6	-0.2	0.6	0.4	-0.2	-0.9	0.9	-0.2	-0.1
Number of live births	1.1	1.5	7.3	0.8	2.7	-0.9	-1.0	0.5	0.3	-1.0	-0.4	-1.8	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.9	0.7	-0.0	0.7	-0.9	-1.4	1.1	0.1	1.4	-1.3	0.7
Pulse rate	1.5	2.5	9.8	-1.4	1.1	-0.5	-1.2	3.1	-0.3	0.4	-1.8	2.0	-1.7
Happiness	1.2	1.4	6.5	-1.7	-2.5	0.2	0.4	1.3	-0.6	-0.6	-1.0	0.2	-0.9
Noisy workplace	0.3	0.3	1.5	0.0	-0.5	0.3	0.5	0.8	-0.5	0.2	0.5	0.3	1.2
Qualifications: A levels/AS levels or equivalent	0.8	1.9	4.9	2.0	-1.2	-1.7	-2.2	0.8	0.3	-1.5	0.5	-0.5	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	4.0	-0.6	0.7	0.1	-0.9	-1.3	-2.0	-0.5	0.1	-0.5	0.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.9	0.7	0.7	-0.5	-0.4	0.1	-1.2	-1.0	-0.7	1.4	-1.2
Asthma	0.2	0.4	1.6	-0.3	-0.7	-0.4	-0.6	-0.4	-1.3	0.7	0.2	0.2	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	5.1	-0.5	-0.4	2.3	1.1	0.7	-0.6	1.6	0.7	0.5	1.1
Medication: Cholesterol lowering	0.2	0.3	1.1	0.1	1.0	0.9	0.8	0.2	0.3	0.7	-0.3	-0.3	-0.1
Depression (self-reported)	0.4	0.5	1.8	0.7	0.2	1.1	0.2	0.5	-1.3	-0.1	0.5	-0.2	0.9
Medication: Lansoprazole	0.6	0.7	3.9	-0.7	-0.9	0.6	0.2	0.0	0.9	-2.0	-0.4	-0.1	-0.7
Prospective memory result	1.0	1.2	3.1	-1.4	1.0	1.8	1.7	0.8	-0.8	0.7	0.5	0.8	0.8
Lung cancer (father)	1.1	1.3	4.7	-2.2	-0.8	1.4	0.4	0.3	-1.5	-1.1	-0.7	-0.6	-0.9
Illnesses of mother	0.5	0.6	2.8	-0.0	0.2	0.5	0.3	0.7	-1.1	-1.2	-1.7	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.1	0.5	-0.7	0.5	-0.6	-1.8	1.8	0.2	1.2	-1.0	0.0
Pulse wave Arterial Stiffness index	1.5	1.8	5.7	0.0	1.8	0.5	1.2	2.4	1.2	1.0	-1.3	1.7	-0.2
Impedance of arm (left)	0.2	1.1	6.4	-0.3	-1.5	-0.0	-0.1	0.2	0.3	-0.7	-0.4	2.5	-1.3
Arm fat mass (right)	0.7	3.1	15.7	-0.0	-0.3	1.3	2.4	1.2	1.1	4.0	1.2	-0.5	1.7
Trunk predicted mass	0.3	1.6	6.0	-0.1	0.6	1.3	0.8	-1.1	0.6	1.6	1.1	-2.4	1.6
Standing height	0.1	1.1	5.2	-0.2	0.4	1.2	0.3	-2.3	1.2	0.7	0.3	-1.4	0.2
Length of working week for main job	0.4	0.5	2.5	0.3	0.3	0.4	0.6	0.1	1.1	-0.5	0.2	-0.2	1.6
Exposure to tobacco smoke at home	1.1	1.2	4.3	1.3	0.2	1.4	-0.3	1.5	-0.3	-0.2	0.3	2.1	1.4
Breastfed as a baby	0.5	0.6	3.3	0.1	1.1	0.1	0.0	-0.3	-1.8	-0.6	0.3	0.3	0.8
Tense / ‘highly strung’	1.3	2.2	6.1	-2.5	-1.3	1.7	2.3	-1.5	-0.4	-0.4	-1.2	-1.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.0	0.8	-0.8	0.8	-0.5	-1.4	-0.9	-0.0	0.6	0.9	-0.2
Hair/balding pattern: Pattern 4	0.7	1.6	4.2	-1.9	0.7	-0.1	0.4	0.7	-1.0	-2.1	-1.9	-1.3	-0.8
Birth weight of first child	0.9	1.7	7.1	-0.0	-2.7	1.2	0.6	-1.6	-1.2	-0.8	1.5	0.5	-0.6
Peak expiratory flow (PEF)	0.4	1.0	2.5	0.2	1.2	1.4	-0.3	-1.4	1.6	-0.3	-1.3	-0.7	0.2
Pulse wave reflection index	0.3	0.4	1.7	-0.3	1.3	0.0	0.5	0.0	0.6	-0.5	0.7	-0.8	0.6
Ever highly irritable/argumentative for 2 days	0.5	0.5	2.0	0.6	-1.4	-1.2	-0.7	0.3	0.1	-0.8	0.2	-0.6	-0.2
Loud music exposure frequency	1.2	1.3	6.0	0.5	-1.3	0.1	-0.6	-1.1	-0.9	-0.4	2.4	0.8	1.4
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.8	-1.2	0.7	-0.2	-0.7	0.7	-1.2	-1.2	-0.8	-1.9	0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.8	-1.1	0.7	-0.9	-0.8	-0.3	-0.9	0.1	1.4	-0.9	1.0
Blood clot in the leg (DVT)	1.2	1.5	4.3	0.1	1.7	1.1	0.7	-1.9	0.3	-0.3	1.6	2.1	0.3
Medication: Paracetamol	0.5	0.8	5.1	-1.2	-0.4	0.5	2.2	-0.7	0.2	0.1	0.2	0.5	-0.2
Headache pain in last month	0.6	1.0	3.2	-1.2	0.6	0.5	-0.5	0.1	-0.3	1.4	1.8	0.4	1.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.9	-0.4	-1.4	-0.3	-0.9	-0.2	-0.7	-2.0	-0.5	0.8	-1.0
Glaucoma (self-reported)	1.5	1.8	7.8	-1.7	0.4	-0.5	-0.5	0.3	-0.8	-0.6	-1.5	-2.8	-1.7
Gout (self-reported)	0.8	1.1	6.0	-1.6	-0.3	-0.5	0.5	-0.7	2.5	-0.5	-0.4	-0.9	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.6	1.3	-0.3	0.3	0.6	-1.0	0.8	-0.4	-0.6	-1.2	-0.2
Medication: Amlodipine	0.6	0.9	2.9	0.2	-0.6	-0.7	-0.2	-0.9	1.4	1.7	1.3	-0.7	0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.2	1.5	-1.2	-0.4	0.1	-0.1	-0.6	-0.2	-0.3	-0.0	0.0	-0.1
Birth weight	0.5	1.1	3.8	-1.3	0.3	1.7	0.9	-0.3	-1.9	1.3	0.3	-0.7	0.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	4.4	0.8	-1.0	0.2	0.4	2.0	2.1	0.5	-2.1	-0.3	-0.5
High blood pressure (siblings)	0.3	0.5	2.4	-0.4	0.4	-0.3	-0.7	-0.6	-0.5	-0.2	0.8	-1.5	-0.3
Forced vital capacity (FVC), Best measure	0.4	1.4	5.0	0.6	-0.6	0.6	-0.3	-2.2	1.8	0.6	2.0	-0.6	0.0
Body fat percentage	0.7	2.9	14.7	0.1	-0.5	1.2	2.4	1.4	1.8	3.8	1.0	0.0	0.9
Leg fat percentage (right)	0.8	3.0	15.0	-0.3	-0.9	1.4	2.2	2.3	0.8	3.9	0.5	-0.2	0.7
Arm fat-free mass (right)	0.4	1.9	6.0	0.4	1.1	1.4	1.3	-0.9	1.0	1.7	0.7	-2.5	1.6
Exposure to tobacco smoke outside home	1.7	2.3	10.6	2.0	0.0	-0.3	-1.5	0.1	-1.1	0.9	3.2	1.1	1.7
Comparative body size at age 10	0.3	0.9	4.6	-0.9	0.1	-0.9	0.6	-0.6	1.2	0.8	0.2	-2.1	-0.3
Number of full brothers	0.8	1.0	4.3	0.7	0.9	-0.8	-1.4	2.1	0.8	-0.6	-0.3	-0.6	0.6
Worry too long after embarrassment	0.1	0.2	0.7	0.0	-0.5	-0.8	-0.6	-0.9	0.2	-0.3	0.3	-0.4	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.1	1.5	-0.9	0.3	-0.2	-0.6	-0.5	0.2	0.9	-0.4	0.4
Wheeze or whistling in the chest in last year	0.4	0.8	2.8	-0.8	-1.2	1.1	1.7	-0.7	-0.1	0.8	-0.4	0.0	-0.2
Number of children fathered	1.3	1.5	4.9	-0.3	1.0	0.3	0.4	1.8	-1.1	2.2	0.1	0.8	1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.8	-0.6	1.0	-0.3	-0.4	-1.7	0.1	-1.7	-0.4	0.5	-1.4
Age at first live birth	1.0	1.8	4.9	-1.4	-0.9	-2.2	-1.9	1.6	-0.2	0.2	-0.9	-1.0	-1.5
Pulse wave peak to peak time	1.5	1.7	5.9	0.1	-1.9	-0.5	-1.1	-2.4	-1.0	-0.9	1.5	-1.5	0.4
Health satisfaction	0.5	0.7	1.8	-0.7	-1.1	-0.5	0.9	0.0	1.4	1.3	-0.6	-0.4	-0.2
Shortness of breath walking on level ground	0.6	0.7	1.8	-1.4	-1.2	0.3	0.9	0.2	0.8	1.0	-0.5	-0.7	0.8
Qualifications: College or University degree	0.5	1.6	9.9	0.9	-1.0	-1.2	-1.5	-0.1	0.4	-3.2	-0.3	-0.3	0.5
Eye problems/disorders: None of the above	0.5	0.6	1.8	-0.2	-0.2	1.3	0.7	0.4	0.3	1.3	-0.7	0.6	0.9
Mouth/teeth dental problems: Loose teeth	1.3	1.5	4.4	1.8	-0.4	-2.1	-1.0	-0.7	-0.2	0.3	1.9	0.2	1.3
Emphysema/chronic bronchitis	1.0	1.1	3.4	-0.3	0.3	0.8	1.5	-0.0	1.8	-1.1	-1.5	-0.6	-0.4
Medication for pain relief, constipation, heartburn	1.0	1.8	8.8	0.9	0.3	-1.5	-3.0	0.8	0.0	-1.9	-1.3	-0.1	-0.4
Neck or shoulder pain in last month	0.4	0.6	1.3	0.7	-0.7	0.2	1.0	0.1	0.3	0.3	1.1	0.9	1.1
Medication: Blood pressure	0.6	1.0	6.4	0.0	0.2	0.2	1.2	0.8	0.5	2.5	0.7	-0.5	0.7
Angina (self-reported)	0.8	1.0	3.8	1.2	1.1	-0.4	-2.0	-0.6	-0.0	-1.4	0.9	-0.1	0.3
Migraine (self-reported)	0.8	1.0	3.5	-1.9	0.8	0.2	0.2	-0.3	1.6	0.6	-1.5	-0.4	-0.7
Medication: Ibuprofen	1.0	1.2	4.6	-0.5	-0.4	1.7	0.5	1.3	-0.4	2.1	0.4	0.5	1.2
Medication: Allopurinol	0.3	0.5	3.1	-0.5	0.1	-0.1	0.9	-0.3	1.8	0.4	-0.2	-0.3	-0.3
Medication: Omeprazole	0.5	0.6	2.5	-0.5	0.5	-0.8	0.0	-0.8	-1.4	-0.4	-0.1	0.3	-1.6
Medication: Seretide 50 evohaler	0.4	0.5	2.8	0.3	0.4	0.1	1.7	-0.9	-1.0	-0.6	0.0	-0.0	0.2
Mean time to correctly identify matches	1.0	1.9	7.4	-1.0	-0.9	-1.7	-0.4	-1.0	-0.8	-2.1	-1.1	0.1	-2.7
Heart disease (mother)	1.5	1.8	5.7	-0.6	-0.7	0.2	-0.6	-1.1	2.4	1.8	2.3	0.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	9.7	-0.4	3.1	1.0	1.5	-0.0	0.3	2.0	-1.1	-0.7	-0.3
Whole body fat mass	0.7	3.1	14.9	0.1	-0.5	1.6	2.4	1.0	1.8	3.9	0.8	-0.6	1.3
Leg fat mass (right)	0.9	3.5	18.0	-0.5	-0.4	1.8	2.6	1.6	1.2	4.2	0.7	-0.8	1.3
Arm predicted mass (right)	0.4	1.9	6.3	0.3	1.1	1.4	1.3	-0.8	0.9	1.8	0.7	-2.5	1.6
Pulse rate, automated reading	0.1	0.4	1.7	-0.4	0.0	0.1	-1.0	1.3	-0.1	0.4	-0.5	0.7	-0.2
Alcohol intake frequency.	0.8	1.9	5.5	-1.9	-0.6	2.1	2.4	0.7	1.1	1.7	-0.8	-0.2	0.0
Comparative height size at age 10	0.2	1.0	2.2	0.6	-0.4	0.3	-0.6	-0.7	1.2	1.2	-1.2	-1.4	-1.5
Number of full sisters	0.5	0.6	2.0	-0.0	-0.5	0.7	-0.3	1.4	-0.1	1.1	0.7	0.0	1.2
Suffer from ‘nerves’	0.3	0.4	1.3	0.3	1.1	-0.8	-0.2	0.1	0.5	1.1	0.2	-0.3	0.8
Overall health rating	1.3	2.7	7.6	-1.3	-1.5	0.9	2.5	0.5	2.7	2.8	-0.5	-0.1	0.9
Chest pain or discomfort	0.6	0.8	2.8	0.9	-1.3	0.2	-0.4	-0.5	-1.0	-0.0	1.7	-0.0	1.3
Had major operations	0.4	0.4	1.2	-0.4	0.9	0.4	1.1	0.3	-0.9	0.2	0.6	-0.3	0.9
Age at last live birth	0.5	0.7	2.0	-1.1	-0.5	-0.9	-1.4	0.5	-0.8	-0.4	0.9	-0.8	-0.0
Family relationship satisfaction	0.3	0.4	1.0	1.0	-0.7	-0.7	-0.4	0.1	0.5	-0.6	-0.3	0.9	-0.1
Leg pain on walking	0.5	0.6	1.9	-0.7	-1.2	-1.4	0.3	-0.3	1.1	0.2	-0.8	-0.4	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	3.4	0.4	0.7	0.6	-0.8	-1.8	0.3	1.4	0.9	-1.0	0.5
Commuting to job workplace: Car/motor vehicle	0.9	1.1	4.7	1.4	-1.3	-0.2	-0.3	-0.4	1.3	2.2	-0.4	-0.4	-0.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.1	0.6	1.0	-0.8	-1.3	0.7	-0.6	-0.6	-0.6	0.9	-1.4
Medication: Aspirin	1.0	1.4	2.9	-0.8	0.6	0.5	1.0	-1.4	1.6	1.7	1.5	-0.6	1.2
Supplements: Vitamin C	1.2	1.5	4.8	-1.3	-0.2	2.2	1.3	-1.0	1.0	1.2	1.0	1.2	0.7
Knee pain experienced in last month	0.7	1.1	2.7	-1.6	-1.6	0.5	1.3	-1.0	1.3	0.9	-0.1	-0.5	0.1
Hypertension (Self-reported)	0.7	2.1	10.4	1.0	-0.7	-0.7	0.8	0.1	1.1	3.2	2.0	0.7	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.8	0.9	-0.3	0.3	0.1	-0.2	0.9	0.8	0.4	-0.7	-0.0
Illnesses of father: Heart disease	0.2	0.3	1.0	1.0	0.2	0.1	-0.1	-0.6	0.5	0.5	0.6	0.5	-0.6
Illnesses of siblings: Diabetes	0.3	0.3	1.7	0.6	0.3	0.7	0.1	0.1	-0.0	1.3	-0.1	-0.9	0.0
Smoking status: Previous	0.8	1.2	8.1	0.3	2.8	0.5	0.5	-1.1	0.7	-0.1	0.0	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	6.1	-0.9	-0.1	1.7	1.0	-0.2	0.8	2.5	-0.1	-0.7	-0.5
Whole body fat-free mass	0.3	2.0	6.4	0.3	0.2	1.3	1.1	-1.0	1.1	1.9	1.1	-2.5	1.9
Leg fat-free mass (right)	0.4	2.3	5.6	0.4	0.4	1.3	1.3	-1.3	1.6	1.9	1.3	-2.2	2.4
Arm fat percentage (left)	0.7	2.7	14.2	0.0	-0.7	1.0	2.2	1.5	1.2	3.8	1.0	0.1	1.5
Average weekly red wine intake	1.6	2.3	7.0	1.9	1.0	-2.2	-1.1	-1.2	1.4	-2.6	0.1	1.0	-1.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.4	0.0	-0.1	-0.5	-1.3	-0.6	-1.4	1.6	2.1	-0.3	-0.1
Mood swings	0.5	0.9	3.2	-0.3	-1.1	1.8	1.2	0.0	-0.0	-0.3	-0.7	1.3	-0.5
Loneliness, isolation	0.6	0.9	2.4	-0.8	-1.5	1.4	0.5	0.9	0.5	-0.1	-0.2	1.6	0.5
Long-standing illness, disability or infirmity	0.7	1.0	3.4	-0.8	-1.8	0.8	1.5	-1.0	0.7	0.0	-0.6	-1.2	-0.1
Ever had bowel cancer screening	0.5	0.6	1.5	-1.2	-1.0	0.4	1.1	0.8	-0.8	-0.1	-0.6	0.2	-0.6
Diabetes diagnosed by doctor	0.6	1.0	2.6	-0.3	-0.7	1.1	0.5	1.2	0.9	-1.4	-1.6	-1.1	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	3.8	-1.9	-0.0	0.4	1.1	-0.6	1.9	-0.5	-1.1	-1.0	-0.8
Friendships satisfaction	0.6	0.8	2.9	0.6	-0.4	-1.3	-1.7	0.8	1.1	-0.3	0.5	0.3	0.0
Qualifications: nursing, teaching	1.1	1.6	10.0	-1.4	-0.4	-0.1	-1.7	-0.4	-0.8	-0.4	-0.6	-3.2	-0.2
Commuting to job workplace: Walk	1.2	1.3	3.8	-1.9	0.3	-0.4	-0.7	-1.2	1.4	-1.6	-0.6	-1.4	-0.4
Eye problems/disorders: Cataract	0.6	0.7	2.4	0.7	-0.3	-1.5	-0.8	0.4	1.0	-1.4	-0.5	-0.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	4.3	-1.2	-0.3	0.7	-0.1	-0.8	-2.1	0.0	0.1	0.9	0.2
Medication for cholesterol	0.7	1.0	2.8	-1.6	0.5	1.0	0.7	1.7	-1.5	-0.0	-0.7	0.4	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.4	0.2	-1.3	-0.5	0.6	-0.1	-1.1	0.6	0.1	-1.6	-0.2
Back pain experienced in last month	0.4	0.6	2.4	-0.3	-0.9	-0.4	0.1	-0.6	1.0	-0.5	-0.4	-1.5	-0.8
Mineral and other dietary supplements	0.7	1.0	5.5	-0.7	-0.6	-0.8	-0.8	-0.6	-2.3	0.5	1.1	0.6	-0.3
Breast cancer (self-reported)	1.0	1.2	3.9	-0.5	-2.0	1.1	0.5	-0.2	-1.6	1.1	0.8	0.4	1.3
Asthma (self-reported)	0.2	0.3	1.2	-0.4	-1.0	-0.3	-0.6	-0.6	-1.1	0.2	0.1	0.1	-0.5
Osteoporosis (self-reported)	1.0	1.3	8.1	-0.2	0.6	-1.0	0.4	0.4	-0.4	2.8	1.2	0.9	0.7
Osteoarthritis (self-reported)	1.0	1.3	4.5	1.1	0.6	0.7	0.9	-2.1	-0.4	-0.1	1.5	-1.4	1.2
Medication: Aspirin	0.8	1.1	3.1	-0.6	0.1	-0.0	0.8	-1.3	1.5	1.8	1.3	-0.8	0.9
Medication: Gliclazide	0.9	1.0	4.0	-0.3	-1.8	-0.6	-0.8	2.0	0.4	0.4	-0.4	-0.7	-0.6
Illnesses of father: None of the above (group 1)	1.2	1.4	3.4	0.1	0.2	-1.2	-1.8	0.9	1.1	-1.7	-1.6	-0.5	-1.2
Smoking status: Current	2.4	3.9	17.6	1.0	1.0	1.7	1.4	1.1	1.5	4.2	1.4	0.7	2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	6.0	-0.3	-0.8	-0.3	-0.6	-2.4	0.1	-1.7	-0.5	-1.4	-1.5
Whole body water mass	0.3	1.9	6.0	0.3	0.4	1.2	1.1	-1.0	1.1	1.8	1.1	-2.5	1.9
Leg predicted mass (right)	0.4	2.4	5.8	0.4	0.4	1.3	1.3	-1.2	1.6	1.9	1.3	-2.2	2.4
Arm fat mass (left)	0.6	2.6	14.0	-0.0	-0.4	1.1	2.0	1.3	1.1	3.7	1.2	-0.6	1.6
Number of self-reported non-cancer illnesses	0.5	0.8	2.4	0.3	0.2	-0.5	0.2	-0.4	1.6	1.3	-0.5	-0.7	-1.5
Average weekly champagne plus white wine intake	0.6	0.9	2.2	-1.3	0.2	-0.7	-1.3	0.4	-0.4	-0.9	-1.1	0.5	-1.5
Miserableness	1.0	1.7	3.9	-1.7	-2.0	1.1	1.9	0.3	-0.2	1.2	-1.1	0.5	-1.4
Guilty feelings	0.8	1.2	2.6	-0.3	-1.0	0.3	1.0	1.6	-1.5	1.2	0.7	1.6	0.1
Wears glasses or contact lenses	0.5	0.6	1.9	1.4	-0.1	-0.4	-0.1	-1.2	-0.3	0.2	1.1	0.6	0.6
Ever taken oral contraceptive pill	0.8	0.9	2.0	-0.0	-0.7	0.8	-0.8	1.3	1.4	0.2	-0.5	-1.2	1.3
Hearing aid user	0.8	0.9	2.1	-0.7	-1.2	-0.0	0.5	-0.9	-1.5	-1.0	-0.7	-1.4	-0.8
Mother’s age at death	0.5	0.7	3.4	0.4	-0.4	-0.3	0.5	-0.2	-1.5	-1.8	0.3	0.1	-0.2
Financial situation satisfaction	1.2	1.5	3.4	-0.9	-1.8	0.6	0.8	0.5	-0.6	1.6	1.4	1.0	1.8
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	0.7	-0.7	-0.1	0.9	0.2	-0.1	-0.1	0.7	0.4	0.1
Commuting to job workplace: Public transport	0.7	0.8	2.9	-0.3	-0.3	-0.3	-0.6	0.7	-1.6	-1.2	0.5	1.7	0.4
Eye problems/disorders: Glaucoma	2.3	2.7	8.3	-2.8	0.3	-1.2	-0.7	-0.2	-1.5	-1.4	-0.9	-2.9	-1.9
Medication: Blood pressure	0.6	1.2	4.0	0.6	-0.6	-1.4	0.1	-1.4	2.0	1.0	1.1	0.6	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.8	0.8	-0.7	-0.0	-0.9	0.5	0.3	-0.1	-0.4	-0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.8	-0.1	0.9	0.4	-0.2	0.8	1.9	-0.9	-1.1	0.1	0.0
High cholesterol (Self-reported)	0.3	0.6	2.2	0.8	0.0	0.0	1.0	0.3	1.5	0.2	-0.8	0.1	-1.2
Medication: Bendroflumethiazide	0.2	0.3	1.3	-1.1	-0.3	-0.8	-0.1	-0.7	0.5	0.3	0.3	-0.5	-0.3
Medication: Paracetamol	0.7	1.0	4.6	-1.9	-0.5	0.4	2.1	-0.7	0.4	0.4	0.2	0.5	-0.7
Medication: Lisinopril	1.0	1.3	3.0	1.4	0.6	-1.4	0.2	0.9	1.6	1.6	0.5	-0.1	1.7
Medication: Atorvastatin	1.2	1.4	3.3	-1.2	1.1	1.5	1.1	-0.8	-0.4	-1.2	-0.9	1.4	-1.8
Illnesses of father: High blood pressure	0.7	0.9	2.5	-1.6	0.7	-0.9	-0.5	-0.4	-1.2	0.9	-0.3	-1.5	-0.7
Alcohol drinker status: Never	1.3	1.5	4.9	-0.2	-0.8	2.2	1.9	-0.4	1.3	0.6	-1.0	1.6	0.2
Ever smoked	1.6	2.7	6.2	2.5	1.9	-0.1	-0.2	-0.8	0.6	2.5	2.3	0.3	2.3
Basal metabolic rate	0.4	2.1	5.2	0.2	0.2	1.5	1.4	-0.6	1.3	2.3	1.1	-2.3	1.9
Leg fat percentage (left)	0.7	2.6	13.5	-0.0	-0.3	1.1	2.4	1.7	1.1	3.7	0.6	-0.3	0.9
Arm fat-free mass (left)	0.4	2.0	5.7	0.3	0.7	1.1	1.2	-0.9	1.1	2.0	1.3	-2.4	1.8
Number of operations (self-reported)	0.7	1.0	4.0	-0.4	0.7	0.5	0.0	-0.3	0.7	-0.8	-2.0	-1.4	-1.4
Average weekly beer plus cider intake	0.2	0.3	1.0	0.7	-0.1	0.9	0.1	0.1	1.0	0.8	-0.4	0.4	-0.1
Irritability	1.1	1.9	6.1	-0.4	-0.9	2.2	2.5	-0.4	-1.5	0.9	-0.3	2.0	-0.3
Risk taking	0.9	1.3	6.8	2.6	-0.3	1.4	0.5	-0.8	0.3	-0.6	0.2	1.7	0.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	4.6	-0.9	-1.3	-0.2	1.6	-1.5	2.1	-0.8	-0.8	-1.5	0.6
Fractured/broken bones in last 5 years	1.2	1.6	6.2	-1.0	-0.5	2.0	2.5	-0.1	0.1	1.9	-0.6	-0.4	0.1
Age started oral contraceptive pill	0.9	1.1	2.8	-0.8	1.4	-1.1	-0.9	0.3	-0.9	-1.2	-0.8	1.7	-0.9
Diastolic blood pressure, automated reading	0.4	1.3	8.2	0.6	1.4	0.4	1.0	-0.3	0.9	2.9	0.5	-0.0	0.5
Ever depressed for a whole week	0.4	0.5	1.3	0.5	-1.1	-1.1	-0.2	-0.2	0.9	0.1	1.1	0.3	-0.3
Unable to work because of sickness or disability	1.8	2.3	8.7	-1.5	0.3	3.0	2.4	0.4	1.3	1.7	-0.2	-0.5	1.0
Commuting to job workplace: Cycle	0.5	0.6	1.5	-0.7	0.6	0.6	0.8	-0.4	0.3	0.8	1.1	-0.4	1.2
Myopia	1.3	1.9	4.8	-0.7	0.3	2.2	2.0	2.1	-0.9	0.7	-1.6	1.2	0.5
Vascular/heart problems diagnosed by doctor	0.7	2.0	11.9	-1.1	-0.0	0.5	-0.4	0.4	-0.6	-3.5	-2.0	0.2	-1.3
Cholesterol lowering medication	0.1	0.2	0.9	0.1	0.5	0.3	1.0	0.1	0.1	0.8	0.5	0.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.1	-0.6	0.9	-0.0	1.4	-0.1	-0.9	0.1	-0.4	1.1	-1.4
Pain experienced in last month	0.5	0.9	2.1	0.9	1.4	-0.6	-1.3	0.6	-1.4	0.2	-0.4	1.2	-0.5
Supplements: Calcium	0.2	0.2	1.6	0.2	-0.3	-0.3	0.1	-0.1	1.3	0.4	0.3	-0.1	0.5
Basal cell carcinoma (self-reported)	1.1	1.3	4.5	1.0	0.8	0.5	-0.0	1.1	-1.0	1.1	2.1	0.8	1.6
Heart attack/myocardial infarction (self-reported)	0.1	0.2	1.2	0.1	1.1	0.2	-0.1	-0.1	0.5	-0.2	-0.1	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.8	-0.0	1.6	0.8	0.8	-1.9	0.1	-0.3	1.5	2.0	0.4
Heart disease (siblings)	1.6	2.0	10.5	1.0	1.7	1.2	0.8	-0.1	0.8	3.2	1.1	0.3	1.1
Alcohol drinker status: Previous	0.7	0.8	4.4	-0.1	1.0	-0.4	0.4	0.7	2.1	0.4	-0.9	0.8	-0.7
Pack years of smoking	0.9	1.3	5.1	0.1	-0.2	0.7	0.6	2.3	-0.7	1.4	0.3	1.7	1.0
Impedance of whole body	0.3	1.3	5.6	-0.6	-0.9	-0.0	-0.1	0.2	0.5	-0.7	-0.9	2.4	-2.0
Leg fat mass (left)	0.9	3.4	17.6	-0.3	0.2	1.6	2.6	1.2	1.5	4.2	0.7	-0.9	1.4
Arm predicted mass (left)	0.4	1.9	5.4	0.2	0.7	1.1	1.2	-0.7	1.1	2.0	1.1	-2.3	1.8