Hub : Genes

ASAM

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0326 0.0121 1.7e-03 0.001 0.007 0.009 0.009 0.001 1.2e-01 1.6e-03 3.9e-04 0.00061 1.7e-01
2 TCGA Prostate Adenocarcinoma 0.0568 0.0252 1.9e-03 0.013 0.027 0.012 NA 0.010 1.3e-02 7.7e-04 1.9e-02 NA 3.0e-02
3 TCGA Thyroid Carcinoma 0.0940 0.0330 3.1e-05 0.052 0.047 0.043 NA 0.053 8.4e-06 2.2e-05 4.9e-05 NA 6.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.2 0.3 0.3 0.4 -0.6
Bipolar Disorder or Schizophrenia 0.0 0.0 0.1 0.3 0.1 0.2
Depressed Affect (Nagel 2018) 0.7 1.4 3.1 0.1 -1.0 1.8
Depression (Nagel 2018) 0.6 0.9 1.4 -1.2 -0.1 1.1
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.2 0.1 -0.6 1.5
Neuroticism (Nagel 2018) 0.6 1.5 2.9 1.1 -0.6 1.7
Schizophrenia (2018) 0.1 0.2 0.5 0.2 -0.2 0.7
Schizophrenia vs Biploar Disorder 0.2 0.3 0.7 0.9 -0.2 -0.0
Worry (Nagel 2018) 1.1 2.3 5.8 2.4 -0.1 1.0
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 0.3 -0.6 0.5
Alzheimer’s Disease (in father) 1.1 1.2 2.3 -0.2 1.1 -1.5
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 0.1 -0.2 -0.3
Crohns Disease (2017) 0.2 0.5 1.5 -1.2 0.0 -0.1
Irritable Bowel Disease (IBD) 0.3 0.7 1.2 -1.1 -0.6 0.6
Ulcerative Colitis (UC) 0.4 0.8 0.9 -0.9 -0.9 0.8
Major Depression (MDD) 2.5 3.0 6.5 -2.5 1.6 -0.4
Reaction Time 0.4 0.8 1.5 -1.2 -1.0 0.2
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.7 -0.1 -0.8 0.7
Breast Cancer 0.1 0.3 0.7 0.2 -0.8 0.3
Ovarian Cancer 1.9 2.5 7.5 -2.7 0.4 -0.1
Prostate Cancer 0.2 0.2 0.5 -0.4 -0.7 0.3
Age at First Birth 0.1 0.1 0.3 0.0 0.5 0.3
Bipolar Disorder (2011) 2.9 2.8 4.3 -0.3 2.0 -2.1
Body Mass Index (BMI) (2010) 1.4 1.9 3.6 0.1 1.9 -1.5
Coronary Artery Disease (CAD) 2.7 3.2 3.5 -1.7 1.8 -1.9
Crohns Disease (2012) 0.2 0.3 0.5 0.7 0.6 -0.4
Mean Putamen Volume 0.3 0.3 0.9 -0.1 0.2 0.9
Fasting Glucose 0.1 0.1 0.2 0.2 -0.3 -0.4
HbA1C 0.8 0.9 1.9 -1.4 -0.7 0.4
HDL Cholesterol 0.7 1.2 3.2 -1.8 0.2 0.7
LDL Cholesterol 1.6 2.5 4.5 -2.1 1.1 -1.3
Lupus 0.0 0.1 0.1 0.3 0.2 0.2
Neuroticism (2016) 0.3 0.5 1.1 -0.5 -0.0 1.0
Primary Biliary Cirrhosis 0.3 0.4 0.8 -0.2 -0.6 0.9
Rheumatoid Arthritis 0.1 0.1 0.4 0.1 -0.2 0.6
Schizophrenia (2014) 0.2 0.5 1.4 0.0 -0.5 1.2
Triglycerides 0.2 0.4 0.8 -0.9 -0.5 -0.1
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.2 -0.5 -0.7 1.5
Ulcerative Colitis 0.0 0.0 0.0 -0.2 -0.2 0.1
Blood Eosinophil Count 0.0 0.3 0.5 -0.5 0.7 0.3
Blood Platelet Count 0.1 0.9 1.2 -0.9 -0.8 1.1
Blood Red Count 0.1 0.8 1.4 -1.2 -0.6 -0.8
Blood White Count 1.4 10.1 13.5 -3.7 -2.8 2.9
Heel T-Score 0.2 1.3 3.8 -0.2 -0.3 1.9
BMI 0.3 1.6 4.2 -2.0 0.8 0.1
Height 0.0 0.1 0.1 -0.3 0.2 0.4
Waist Hip Ratio (WHR) 0.5 2.3 3.7 -1.1 -1.9 1.4
Systolic Blood Pressure 0.5 2.3 6.3 0.6 0.3 -2.5
Smoking Status 0.3 0.6 0.8 0.7 0.9 -0.7
Allergy or Eczema 0.5 1.3 3.7 1.9 0.3 -0.2
Cardiovascular Disease 0.1 0.3 0.7 -0.9 0.2 -0.4
Hypothyroidism (self reported) 0.4 1.0 2.7 1.7 -0.1 -0.6
Respiratory disease 0.3 0.7 1.4 0.7 1.2 -0.5
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.3 0.0 -0.3 0.5
Lung FEV1/FVC ratio 0.3 1.6 4.4 -2.1 -0.1 -0.7
Lung FVC 0.3 1.5 3.2 0.3 1.1 -1.8
Neuroticism 0.3 0.7 1.0 1.0 -0.5 0.9
Chronotype (morning person) 0.1 0.2 0.2 0.3 -0.5 -0.4
Hair Pigment 0.0 0.6 1.2 -1.1 -0.3 -0.7
Tanning 0.0 0.5 1.4 1.2 0.1 -0.3
Hand grip strength (left) 0.1 0.3 0.5 0.7 0.6 -0.0
Number of treatments/medications taken 0.1 0.2 0.3 -0.2 0.6 -0.5
Average weekly spirits intake 0.1 0.1 0.1 -0.3 -0.2 0.4
Sensitivity / hurt feelings 0.1 0.1 0.2 0.4 0.2 0.4
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.6 -0.3 -0.7 1.3
Hearing difficulty/problems: Yes 1.1 1.6 3.0 0.5 1.7 -1.2
Relative age of first facial hair 0.4 0.8 1.2 -0.5 1.1 -1.0
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 -0.4 -0.1 0.8
Ever used hormone-replacement therapy (HRT) 0.7 0.8 2.2 -1.5 0.5 0.2
Ever had hysterectomy (womb removed) 2.1 2.4 4.5 -2.1 1.0 -1.2
Systolic blood pressure, automated reading 0.6 1.8 4.6 -0.8 -0.4 -2.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.0 0.5 -1.0 0.9
Angina 1.1 1.4 3.9 -2.0 0.6 0.0
Medication for hormone replacement therapy 0.5 0.6 1.6 -1.3 0.2 0.2
Vitamin and mineral supplements 1.0 1.4 1.7 -1.3 1.1 -1.1
Supplements: Zinc 1.0 1.1 2.9 -0.1 -1.7 0.7
Medication: Co-codamol 0.0 0.0 0.0 0.1 -0.2 -0.2
Medication: Metformin 1.8 2.6 3.3 1.8 -1.2 1.7
Diabetes (father) 2.3 2.8 5.8 -2.4 1.6 -0.4
Diabetes (mother) 0.5 0.6 1.3 -1.1 -0.1 0.7
Severe depression (siblings) 2.0 2.3 5.5 2.4 1.1 -0.3
Pack years adult smoking proportion 0.2 0.3 0.6 0.5 0.8 -0.1
Impedance of leg (right) 0.3 1.6 2.3 -1.5 1.2 -1.0
Leg fat-free mass (left) 0.1 0.6 1.6 -0.3 -0.5 1.2
Trunk fat percentage 0.3 1.4 3.6 -1.9 0.7 0.0
Hand grip strength (right) 0.1 0.3 0.5 0.7 0.0 0.7
Townsend deprivation index at recruitment 0.4 0.5 1.0 0.7 -0.3 1.0
Current tobacco smoking 0.2 0.3 0.6 -0.2 -0.8 0.4
Average weekly fortified wine intake 0.3 0.4 0.8 0.9 -0.6 0.1
Maternal smoking around birth 1.0 1.5 4.4 2.1 0.4 -0.1
Fed-up feelings 0.0 0.1 0.2 -0.3 0.4 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 -0.5 0.2 0.8
Relative age voice broke 0.4 0.6 1.6 -1.2 0.1 0.5
Taking other prescription medications 0.2 0.4 0.7 -0.6 0.9 0.1
Age when periods started (menarche) 1.6 3.8 5.7 -2.4 1.9 -1.4
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 2.1 -1.5 -0.8 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.1 0.2 -0.4 0.1 0.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 -0.6 -0.9 -0.1
Qualifications: CSEs or equivalent 0.4 0.5 1.6 -1.2 0.2 -0.2
Serious illness, injury or assault to yourself 1.3 1.6 4.0 -0.2 2.0 -0.8
High blood pressure 0.7 1.9 4.5 -2.1 0.0 -1.1
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.4 1.2 0.3 -0.3
Multivitamins +/- minerals 2.4 3.0 5.0 2.2 -1.5 1.3
Stomach or abdominal pain in last month 3.3 4.1 9.6 -0.5 3.1 -1.6
Supplements: Glucosamine 0.2 0.2 0.5 0.7 -0.1 0.4
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 1.8 -1.4 1.1 -0.1
Medication: Atenolol 0.4 0.4 0.5 -0.7 -0.6 -0.7
Medication: Levothyroxine sodium 0.1 0.1 0.2 0.3 0.0 -0.4
Sitting height 0.2 1.6 4.2 -0.8 2.1 -0.2
Chronic bronchitis/emphysema (father) 1.1 1.3 2.3 0.4 -1.5 1.2
High blood pressure (mother) 1.0 1.3 2.2 -0.3 1.3 -1.5
Body mass index (BMI) 0.2 0.9 2.2 -1.5 -0.0 0.6
Impedance of leg (left) 0.4 1.7 3.1 -1.8 0.7 -1.3
Leg predicted mass (left) 0.1 0.6 1.5 -0.3 -0.5 1.2
Trunk fat mass 0.3 1.3 3.6 -1.9 0.4 0.4
Waist circumference 0.6 2.2 4.8 -2.2 -0.6 1.2
Number of incorrect matches in round 0.1 0.2 0.4 0.0 -0.6 0.4
Past tobacco smoking 0.3 0.6 1.6 -0.4 -1.3 0.0
Alcohol usually taken with meals 0.9 1.4 2.9 1.7 0.1 1.1
Nervous feelings 0.4 0.8 1.2 1.1 -0.8 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.4 0.4 -0.5 1.2
Hearing difficulty/problems with background noise 0.3 0.5 1.4 0.0 1.2 -0.0
Hair/balding pattern: Pattern 2 0.5 0.6 1.3 -0.7 -0.1 -1.2
Had menopause 0.1 0.1 0.2 -0.3 -0.2 0.5
Had other major operations 0.2 0.2 0.3 -0.4 0.5 0.5
Forced vital capacity (FVC) 0.7 2.8 4.9 0.5 1.8 -2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.1 -0.2 -0.0 1.1
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 3.2 -1.6 1.8 -0.7
Qualifications: None of the above 1.1 2.4 2.7 -1.6 -1.5 1.6
Financial difficulties in last 2 years 1.1 1.5 3.1 -1.8 1.2 -0.2
Mouth/teeth dental problems 0.3 0.5 0.7 0.4 -0.8 0.9
Heart attack 1.6 2.0 3.2 -1.5 -1.8 0.8
Allergy 0.5 1.2 2.9 -1.7 0.4 -0.8
Pain all over the body in last month 1.2 1.2 2.5 1.6 -0.7 0.8
Diabetes (self-reported) 0.4 0.6 0.9 0.7 -0.7 1.0
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.6 -0.1 1.3 -0.7
Medication: Ramipril 1.5 1.9 3.9 -0.6 -2.0 1.2
Medication: Simvastatin 0.2 0.3 0.5 0.6 -0.2 0.7
Fluid intelligence score 0.4 0.9 2.1 0.7 -1.5 0.1
Illnesses of siblings 0.9 1.3 2.0 0.9 1.1 -1.4
Neuroticism score 0.6 1.3 1.4 1.2 -1.0 1.2
Weight 0.2 1.1 2.7 -1.6 -0.0 0.8
Impedance of arm (right) 0.7 3.3 5.9 -0.4 2.0 -2.4
Arm fat percentage (right) 0.2 0.9 2.3 -1.5 0.6 0.1
Trunk fat-free mass 0.2 1.4 2.4 -0.7 -1.2 1.5
Hip circumference 0.2 0.9 2.5 -1.6 0.4 -0.0
Time employed in main current job 1.0 1.2 2.6 -0.4 0.9 -1.6
Alcohol intake versus 10 years previously 0.9 1.3 3.8 -2.0 0.1 0.2
Father’s age at death 0.3 0.4 0.6 0.5 -0.4 0.8
Worrier / anxious feelings 1.1 2.0 4.9 2.2 -0.1 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 0.7 -0.8 -0.3 0.6
Falls in the last year 0.7 1.0 1.4 -1.0 -0.8 1.2
Hair/balding pattern: Pattern 3 0.3 0.4 1.2 -1.1 0.1 0.2
Number of live births 0.4 0.6 1.1 -0.8 0.4 -1.0
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 4.5 -0.4 1.8 -2.1
Pulse rate 1.5 2.6 7.0 -0.7 -0.5 2.6
Happiness 0.3 0.3 0.6 -0.6 0.8 -0.3
Noisy workplace 1.0 1.3 3.2 -1.8 0.7 -0.5
Qualifications: A levels/AS levels or equivalent 0.8 1.8 4.8 2.2 -0.1 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.6 0.8 0.5 -0.4
Mouth/teeth dental problems: Dentures 0.2 0.3 0.6 0.8 -0.5 0.1
Asthma 0.2 0.5 0.8 0.9 -0.5 0.7
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 5.6 -2.4 -0.5 0.4
Medication: Cholesterol lowering 0.2 0.3 0.4 0.5 0.3 0.6
Depression (self-reported) 1.5 1.8 3.4 0.0 1.9 -1.4
Medication: Lansoprazole 0.1 0.1 0.4 0.1 -0.6 -0.2
Prospective memory result 0.6 0.7 1.1 0.9 -1.0 0.4
Lung cancer (father) 0.2 0.2 0.7 0.8 0.1 0.1
Illnesses of mother 0.9 1.1 2.8 -0.3 -0.7 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 3.7 0.1 1.2 -1.9
Pulse wave Arterial Stiffness index 0.3 0.3 0.6 0.6 0.3 0.8
Impedance of arm (left) 0.5 2.4 4.3 0.1 1.7 -2.1
Arm fat mass (right) 0.2 0.9 2.4 -1.5 0.2 0.6
Trunk predicted mass 0.3 1.5 2.4 -0.8 -1.2 1.6
Standing height 0.0 0.1 0.4 -0.6 0.0 0.1
Length of working week for main job 1.6 1.8 3.1 -0.1 -1.8 1.5
Exposure to tobacco smoke at home 0.8 0.8 1.7 0.1 1.3 -0.9
Breastfed as a baby 0.3 0.4 0.7 -0.7 0.2 0.9
Tense / ‘highly strung’ 1.9 3.2 7.3 2.7 -0.9 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.9 -0.5 1.7 -1.2
Hair/balding pattern: Pattern 4 0.1 0.2 0.3 -0.5 0.6 -0.4
Birth weight of first child 1.3 2.4 3.8 2.0 0.0 1.9
Peak expiratory flow (PEF) 0.2 0.5 0.9 -0.5 1.0 -0.5
Pulse wave reflection index 0.9 1.1 2.3 1.0 0.3 -1.5
Ever highly irritable/argumentative for 2 days 1.7 2.0 3.2 -0.0 1.8 -1.7
Loud music exposure frequency 0.5 0.6 1.6 -0.0 -0.4 1.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 1.4 0.4 0.8 -1.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.4 0.1 0.9 -1.2
Blood clot in the leg (DVT) 0.8 1.0 1.1 0.9 -1.0 1.1
Medication: Paracetamol 0.6 0.9 1.9 -0.7 -0.5 1.4
Headache pain in last month 2.0 3.4 4.6 -2.1 1.9 -1.4
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 1.9 -1.4 0.6 -1.0
Glaucoma (self-reported) 0.6 0.6 1.2 -1.1 0.7 0.5
Gout (self-reported) 0.4 0.6 1.0 -1.0 0.1 -0.8
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 4.6 2.2 0.2 -0.2
Medication: Amlodipine 0.5 0.7 0.8 0.8 -0.8 0.9
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.0 1.0 -0.2 0.9
Birth weight 0.2 0.4 1.3 1.1 0.1 -0.1
Chronic bronchitis/emphysema (mother) 1.4 1.6 3.9 1.0 0.2 -2.0
High blood pressure (siblings) 1.1 1.6 2.5 -0.7 -1.6 1.4
Forced vital capacity (FVC), Best measure 0.7 2.4 4.5 0.7 1.5 -2.1
Body fat percentage 0.4 1.5 4.1 -2.0 0.6 0.2
Leg fat percentage (right) 0.8 3.0 8.7 -3.0 0.6 0.0
Arm fat-free mass (right) 0.6 3.1 4.8 -0.8 -2.0 2.2
Exposure to tobacco smoke outside home 0.4 0.5 1.2 -1.1 -0.4 0.2
Comparative body size at age 10 1.4 3.8 7.4 0.8 -2.7 1.8
Number of full brothers 1.2 1.5 3.1 0.9 1.8 -0.8
Worry too long after embarrassment 0.1 0.1 0.3 -0.1 0.3 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.3 0.1 0.1 -0.6
Wheeze or whistling in the chest in last year 0.7 1.3 2.5 -0.4 -1.1 1.6
Number of children fathered 0.6 0.7 1.2 0.9 -1.1 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.7 0.8 -0.3 0.7
Age at first live birth 0.3 0.6 1.5 1.2 -0.5 0.1
Pulse wave peak to peak time 0.2 0.3 0.4 -0.6 -0.3 -0.6
Health satisfaction 3.6 4.7 6.2 -2.3 2.5 -1.6
Shortness of breath walking on level ground 0.9 1.0 2.4 0.5 1.6 -0.6
Qualifications: College or University degree 1.0 3.2 7.6 2.8 -0.7 1.3
Eye problems/disorders: None of the above 1.1 1.3 2.1 0.1 1.3 -1.5
Mouth/teeth dental problems: Loose teeth 1.2 1.5 4.3 0.2 0.3 2.1
Emphysema/chronic bronchitis 0.4 0.5 1.0 1.0 0.5 0.4
Medication for pain relief, constipation, heartburn 1.5 2.5 4.6 2.1 0.9 -1.5
Neck or shoulder pain in last month 0.6 0.9 2.4 -0.0 0.4 -1.5
Medication: Blood pressure 0.0 0.0 0.0 0.1 -0.0 -0.0
Angina (self-reported) 1.0 1.3 3.3 -1.8 0.7 -0.1
Migraine (self-reported) 0.8 1.0 1.6 -0.6 1.0 -1.3
Medication: Ibuprofen 1.0 1.2 3.3 -1.8 -0.1 0.4
Medication: Allopurinol 0.5 0.7 1.2 0.9 0.1 -1.1
Medication: Omeprazole 0.9 1.0 1.7 -0.5 -1.1 1.3
Medication: Seretide 50 evohaler 0.1 0.1 0.3 -0.3 -0.6 0.1
Mean time to correctly identify matches 0.8 1.5 2.7 -1.6 -1.3 0.4
Heart disease (mother) 0.6 0.8 0.9 -0.8 0.9 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.7 0.8 0.8 -0.0
Whole body fat mass 0.3 1.2 3.1 -1.8 0.3 0.6
Leg fat mass (right) 0.6 2.1 5.7 -2.4 0.6 0.5
Arm predicted mass (right) 0.5 2.4 3.9 -0.9 -1.6 2.0
Pulse rate, automated reading 4.3 14.0 28.9 -0.8 -3.5 5.4
Alcohol intake frequency. 0.2 0.4 1.3 -1.1 0.2 0.1
Comparative height size at age 10 0.1 0.6 1.4 -0.6 -1.2 0.4
Number of full sisters 1.1 1.3 3.5 -1.9 0.3 0.5
Suffer from ‘nerves’ 1.1 1.7 3.6 1.9 -0.9 0.7
Overall health rating 0.6 1.3 2.7 -0.4 -1.0 1.7
Chest pain or discomfort 0.1 0.2 0.3 -0.6 0.4 -0.2
Had major operations 0.1 0.1 0.2 -0.2 -0.5 0.1
Age at last live birth 0.7 1.1 2.6 1.6 -0.6 0.4
Family relationship satisfaction 0.1 0.1 0.4 -0.6 0.1 0.2
Leg pain on walking 0.6 0.8 1.8 -0.2 1.3 -0.7
Qualifications: NVQ or HND or HNC or equivalent 2.8 3.4 3.9 -1.8 1.8 -2.0
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.4 0.5 0.1
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.6 0.5 -1.3 -0.2
Medication: Aspirin 0.7 0.9 1.4 -0.3 -1.2 1.1
Supplements: Vitamin C 0.5 0.6 1.3 -1.1 0.4 -0.6
Knee pain experienced in last month 0.4 0.6 1.0 0.6 -1.0 0.6
Hypertension (Self-reported) 0.6 1.6 4.4 -2.1 -0.0 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 7.1 -2.7 -0.2 -0.9
Illnesses of father: Heart disease 0.8 1.1 2.5 0.9 1.6 -0.1
Illnesses of siblings: Diabetes 0.1 0.1 0.1 -0.3 0.4 0.1
Smoking status: Previous 0.8 1.2 2.7 0.3 1.6 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.5 0.2 0.7 -0.0
Whole body fat-free mass 0.2 1.2 2.3 -0.5 -1.1 1.5
Leg fat-free mass (right) 0.1 0.6 1.2 -0.2 -0.8 1.1
Arm fat percentage (left) 0.2 0.8 2.1 -1.4 0.5 0.3
Average weekly red wine intake 0.7 1.0 1.6 1.3 0.2 -1.1
Handedness (chirality/laterality): Left-handed 0.8 0.9 1.8 -0.6 0.8 -1.3
Mood swings 0.3 0.5 1.0 -0.7 0.2 1.0
Loneliness, isolation 0.9 1.3 2.6 0.4 -1.0 1.6
Long-standing illness, disability or infirmity 1.0 1.6 3.0 0.6 -1.2 1.7
Ever had bowel cancer screening 0.1 0.1 0.2 0.5 -0.2 0.3
Diabetes diagnosed by doctor 0.4 0.6 0.9 0.5 -0.8 0.9
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.3 3.4 1.9 1.8 0.5
Friendships satisfaction 0.7 0.9 2.6 0.1 -0.2 1.6
Qualifications: nursing, teaching 0.8 1.2 3.5 1.9 -0.0 0.1
Commuting to job workplace: Walk 0.4 0.4 0.9 -0.0 0.6 -0.9
Eye problems/disorders: Cataract 1.5 1.7 4.5 -0.1 -0.8 2.1
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.7 0.3 0.8 -0.0
Medication for cholesterol 0.2 0.3 0.6 0.4 0.8 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 1.8 -1.3 0.9 -0.1
Back pain experienced in last month 0.5 0.7 1.8 -0.3 1.4 -0.5
Mineral and other dietary supplements 1.1 1.5 2.9 -0.8 1.7 -0.9
Breast cancer (self-reported) 0.4 0.5 0.9 -0.6 0.9 -0.5
Asthma (self-reported) 0.3 0.5 0.8 0.8 -0.4 0.9
Osteoporosis (self-reported) 0.1 0.1 0.2 0.4 0.2 -0.4
Osteoarthritis (self-reported) 0.6 0.8 1.4 0.8 -1.2 0.5
Medication: Aspirin 0.8 1.0 1.6 -0.3 -1.3 1.1
Medication: Gliclazide 3.5 3.9 8.6 2.9 -0.9 1.5
Illnesses of father: None of the above (group 1) 1.8 2.3 3.7 0.3 -1.9 1.7
Smoking status: Current 0.1 0.2 0.5 -0.1 -0.7 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 4.1 0.3 2.0 -1.1
Whole body water mass 0.2 1.3 2.5 -0.5 -1.1 1.6
Leg predicted mass (right) 0.1 0.6 1.3 -0.2 -0.8 1.1
Arm fat mass (left) 0.2 0.8 1.7 -1.3 0.1 0.7
Number of self-reported non-cancer illnesses 0.7 1.2 2.1 -1.0 1.4 -0.7
Average weekly champagne plus white wine intake 0.6 0.8 1.6 1.2 0.8 0.4
Miserableness 0.5 0.8 1.4 0.8 -1.2 0.5
Guilty feelings 1.6 2.5 5.1 0.6 2.3 -1.4
Wears glasses or contact lenses 0.8 0.9 1.1 -1.0 -0.9 0.9
Ever taken oral contraceptive pill 0.2 0.2 0.3 0.6 0.5 0.2
Hearing aid user 0.2 0.2 0.5 0.7 0.1 0.1
Mother’s age at death 2.7 3.4 7.6 -0.5 -2.8 1.5
Financial situation satisfaction 0.3 0.4 0.8 -0.4 0.5 -0.9
Tinnitus: Yes, now most or all of the time 1.5 1.7 2.7 -1.6 1.3 -0.8
Commuting to job workplace: Public transport 0.5 0.6 0.8 -0.5 0.9 -0.9
Eye problems/disorders: Glaucoma 0.7 0.8 1.5 -1.2 0.8 0.5
Medication: Blood pressure 0.2 0.4 0.6 -0.7 -0.8 -0.1
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.4 -0.3 -0.1 0.7
Supplements: Fish oil (including cod liver oil) 1.7 2.2 3.9 1.2 -2.0 1.1
High cholesterol (Self-reported) 0.4 0.7 1.0 0.7 -0.7 1.0
Medication: Bendroflumethiazide 0.3 0.5 1.0 -0.5 -0.4 -1.0
Medication: Paracetamol 0.4 0.7 1.2 -0.8 -0.5 1.1
Medication: Lisinopril 1.1 1.5 2.6 -1.2 0.5 -1.6
Medication: Atorvastatin 0.5 0.6 0.9 -1.0 -0.7 0.5
Illnesses of father: High blood pressure 1.0 1.2 2.5 -0.2 1.0 -1.6
Alcohol drinker status: Never 0.6 0.7 1.2 -0.2 -1.1 0.8
Ever smoked 0.5 0.9 1.5 -0.9 1.2 -0.7
Basal metabolic rate 0.2 1.2 2.1 -0.8 -0.9 1.5
Leg fat percentage (left) 0.8 3.0 8.9 -3.0 0.1 -0.0
Arm fat-free mass (left) 0.3 1.7 2.2 -1.3 -1.1 1.5
Number of operations (self-reported) 0.5 0.7 1.4 -1.2 -0.4 0.8
Average weekly beer plus cider intake 0.4 0.6 0.9 -0.9 -0.3 -0.9
Irritability 0.8 1.3 1.8 0.6 -1.4 1.3
Risk taking 0.5 0.8 2.3 0.2 -0.1 1.5
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.5 0.7 -0.7 -0.3
Fractured/broken bones in last 5 years 2.0 2.6 3.1 1.6 -1.8 1.5
Age started oral contraceptive pill 1.4 1.8 3.8 -1.9 -0.8 -0.9
Diastolic blood pressure, automated reading 0.9 2.9 5.7 -1.4 1.0 -2.4
Ever depressed for a whole week 1.1 1.4 2.0 -1.3 1.4 -0.8
Unable to work because of sickness or disability 1.2 1.6 3.5 -0.1 -1.1 1.9
Commuting to job workplace: Cycle 0.4 0.5 1.4 -0.2 -1.2 0.0
Myopia 3.3 4.7 5.8 2.1 -2.0 2.4
Vascular/heart problems diagnosed by doctor 0.9 2.4 5.3 2.3 -0.3 1.3
Cholesterol lowering medication 0.2 0.3 0.7 -0.3 -0.8 0.4
Medication: Omeprazole (e.g. Zanprol) 0.5 0.7 1.0 -0.6 -1.0 0.8
Pain experienced in last month 1.1 1.8 3.7 0.3 -1.9 1.2
Supplements: Calcium 1.0 1.1 3.2 -1.8 -0.2 0.1
Basal cell carcinoma (self-reported) 0.2 0.3 0.5 -0.6 -0.7 0.0
Heart attack/myocardial infarction (self-reported) 1.4 1.9 3.1 -1.4 -1.8 0.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 0.8 0.7 -0.9 0.9
Heart disease (siblings) 0.2 0.2 0.5 0.1 0.2 0.7
Alcohol drinker status: Previous 0.7 0.8 1.8 -0.3 1.4 -0.7
Pack years of smoking 0.2 0.3 0.7 0.2 0.8 -0.4
Impedance of whole body 0.4 2.0 3.4 -0.7 1.5 -1.8
Leg fat mass (left) 0.5 2.0 5.4 -2.3 0.3 0.6
Arm predicted mass (left) 0.4 1.9 2.1 -1.4 -1.3 1.4