Hub : Genes

ASAM

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0326	0.0121	1.7e-03	0.001	0.007	0.009	0.009	0.001	1.2e-01	1.6e-03	3.9e-04	0.00061	1.7e-01
2	TCGA	Prostate Adenocarcinoma	0.0568	0.0252	1.9e-03	0.013	0.027	0.012	NA	0.010	1.3e-02	7.7e-04	1.9e-02	NA	3.0e-02
3	TCGA	Thyroid Carcinoma	0.0940	0.0330	3.1e-05	0.052	0.047	0.043	NA	0.053	8.4e-06	2.2e-05	4.9e-05	NA	6.2e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.3	0.3	0.4	-0.6
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.3	0.1	0.2
Depressed Affect (Nagel 2018)	0.7	1.4	3.1	0.1	-1.0	1.8
Depression (Nagel 2018)	0.6	0.9	1.4	-1.2	-0.1	1.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	0.1	-0.6	1.5
Neuroticism (Nagel 2018)	0.6	1.5	2.9	1.1	-0.6	1.7
Schizophrenia (2018)	0.1	0.2	0.5	0.2	-0.2	0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.9	-0.2	-0.0
Worry (Nagel 2018)	1.1	2.3	5.8	2.4	-0.1	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.3	-0.6	0.5
Alzheimer’s Disease (in father)	1.1	1.2	2.3	-0.2	1.1	-1.5
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.1	-0.2	-0.3
Crohns Disease (2017)	0.2	0.5	1.5	-1.2	0.0	-0.1
Irritable Bowel Disease (IBD)	0.3	0.7	1.2	-1.1	-0.6	0.6
Ulcerative Colitis (UC)	0.4	0.8	0.9	-0.9	-0.9	0.8
Major Depression (MDD)	2.5	3.0	6.5	-2.5	1.6	-0.4
Reaction Time	0.4	0.8	1.5	-1.2	-1.0	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.1	-0.8	0.7
Breast Cancer	0.1	0.3	0.7	0.2	-0.8	0.3
Ovarian Cancer	1.9	2.5	7.5	-2.7	0.4	-0.1
Prostate Cancer	0.2	0.2	0.5	-0.4	-0.7	0.3
Age at First Birth	0.1	0.1	0.3	0.0	0.5	0.3
Bipolar Disorder (2011)	2.9	2.8	4.3	-0.3	2.0	-2.1
Body Mass Index (BMI) (2010)	1.4	1.9	3.6	0.1	1.9	-1.5
Coronary Artery Disease (CAD)	2.7	3.2	3.5	-1.7	1.8	-1.9
Crohns Disease (2012)	0.2	0.3	0.5	0.7	0.6	-0.4
Mean Putamen Volume	0.3	0.3	0.9	-0.1	0.2	0.9
Fasting Glucose	0.1	0.1	0.2	0.2	-0.3	-0.4
HbA1C	0.8	0.9	1.9	-1.4	-0.7	0.4
HDL Cholesterol	0.7	1.2	3.2	-1.8	0.2	0.7
LDL Cholesterol	1.6	2.5	4.5	-2.1	1.1	-1.3
Lupus	0.0	0.1	0.1	0.3	0.2	0.2
Neuroticism (2016)	0.3	0.5	1.1	-0.5	-0.0	1.0
Primary Biliary Cirrhosis	0.3	0.4	0.8	-0.2	-0.6	0.9
Rheumatoid Arthritis	0.1	0.1	0.4	0.1	-0.2	0.6
Schizophrenia (2014)	0.2	0.5	1.4	0.0	-0.5	1.2
Triglycerides	0.2	0.4	0.8	-0.9	-0.5	-0.1
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.2	-0.5	-0.7	1.5
Ulcerative Colitis	0.0	0.0	0.0	-0.2	-0.2	0.1
Blood Eosinophil Count	0.0	0.3	0.5	-0.5	0.7	0.3
Blood Platelet Count	0.1	0.9	1.2	-0.9	-0.8	1.1
Blood Red Count	0.1	0.8	1.4	-1.2	-0.6	-0.8
Blood White Count	1.4	10.1	13.5	-3.7	-2.8	2.9
Heel T-Score	0.2	1.3	3.8	-0.2	-0.3	1.9
BMI	0.3	1.6	4.2	-2.0	0.8	0.1
Height	0.0	0.1	0.1	-0.3	0.2	0.4
Waist Hip Ratio (WHR)	0.5	2.3	3.7	-1.1	-1.9	1.4
Systolic Blood Pressure	0.5	2.3	6.3	0.6	0.3	-2.5
Smoking Status	0.3	0.6	0.8	0.7	0.9	-0.7
Allergy or Eczema	0.5	1.3	3.7	1.9	0.3	-0.2
Cardiovascular Disease	0.1	0.3	0.7	-0.9	0.2	-0.4
Hypothyroidism (self reported)	0.4	1.0	2.7	1.7	-0.1	-0.6
Respiratory disease	0.3	0.7	1.4	0.7	1.2	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	0.0	-0.3	0.5
Lung FEV1/FVC ratio	0.3	1.6	4.4	-2.1	-0.1	-0.7
Lung FVC	0.3	1.5	3.2	0.3	1.1	-1.8
Neuroticism	0.3	0.7	1.0	1.0	-0.5	0.9
Chronotype (morning person)	0.1	0.2	0.2	0.3	-0.5	-0.4
Hair Pigment	0.0	0.6	1.2	-1.1	-0.3	-0.7
Tanning	0.0	0.5	1.4	1.2	0.1	-0.3
Hand grip strength (left)	0.1	0.3	0.5	0.7	0.6	-0.0
Number of treatments/medications taken	0.1	0.2	0.3	-0.2	0.6	-0.5
Average weekly spirits intake	0.1	0.1	0.1	-0.3	-0.2	0.4
Sensitivity / hurt feelings	0.1	0.1	0.2	0.4	0.2	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	-0.3	-0.7	1.3
Hearing difficulty/problems: Yes	1.1	1.6	3.0	0.5	1.7	-1.2
Relative age of first facial hair	0.4	0.8	1.2	-0.5	1.1	-1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.4	-0.1	0.8
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.2	-1.5	0.5	0.2
Ever had hysterectomy (womb removed)	2.1	2.4	4.5	-2.1	1.0	-1.2
Systolic blood pressure, automated reading	0.6	1.8	4.6	-0.8	-0.4	-2.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.0	0.5	-1.0	0.9
Angina	1.1	1.4	3.9	-2.0	0.6	0.0
Medication for hormone replacement therapy	0.5	0.6	1.6	-1.3	0.2	0.2
Vitamin and mineral supplements	1.0	1.4	1.7	-1.3	1.1	-1.1
Supplements: Zinc	1.0	1.1	2.9	-0.1	-1.7	0.7
Medication: Co-codamol	0.0	0.0	0.0	0.1	-0.2	-0.2
Medication: Metformin	1.8	2.6	3.3	1.8	-1.2	1.7
Diabetes (father)	2.3	2.8	5.8	-2.4	1.6	-0.4
Diabetes (mother)	0.5	0.6	1.3	-1.1	-0.1	0.7
Severe depression (siblings)	2.0	2.3	5.5	2.4	1.1	-0.3
Pack years adult smoking proportion	0.2	0.3	0.6	0.5	0.8	-0.1
Impedance of leg (right)	0.3	1.6	2.3	-1.5	1.2	-1.0
Leg fat-free mass (left)	0.1	0.6	1.6	-0.3	-0.5	1.2
Trunk fat percentage	0.3	1.4	3.6	-1.9	0.7	0.0
Hand grip strength (right)	0.1	0.3	0.5	0.7	0.0	0.7
Townsend deprivation index at recruitment	0.4	0.5	1.0	0.7	-0.3	1.0
Current tobacco smoking	0.2	0.3	0.6	-0.2	-0.8	0.4
Average weekly fortified wine intake	0.3	0.4	0.8	0.9	-0.6	0.1
Maternal smoking around birth	1.0	1.5	4.4	2.1	0.4	-0.1
Fed-up feelings	0.0	0.1	0.2	-0.3	0.4	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.5	0.2	0.8
Relative age voice broke	0.4	0.6	1.6	-1.2	0.1	0.5
Taking other prescription medications	0.2	0.4	0.7	-0.6	0.9	0.1
Age when periods started (menarche)	1.6	3.8	5.7	-2.4	1.9	-1.4
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.1	-1.5	-0.8	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.2	-0.4	0.1	0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	-0.6	-0.9	-0.1
Qualifications: CSEs or equivalent	0.4	0.5	1.6	-1.2	0.2	-0.2
Serious illness, injury or assault to yourself	1.3	1.6	4.0	-0.2	2.0	-0.8
High blood pressure	0.7	1.9	4.5	-2.1	0.0	-1.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.4	1.2	0.3	-0.3
Multivitamins +/- minerals	2.4	3.0	5.0	2.2	-1.5	1.3
Stomach or abdominal pain in last month	3.3	4.1	9.6	-0.5	3.1	-1.6
Supplements: Glucosamine	0.2	0.2	0.5	0.7	-0.1	0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	1.8	-1.4	1.1	-0.1
Medication: Atenolol	0.4	0.4	0.5	-0.7	-0.6	-0.7
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.3	0.0	-0.4
Sitting height	0.2	1.6	4.2	-0.8	2.1	-0.2
Chronic bronchitis/emphysema (father)	1.1	1.3	2.3	0.4	-1.5	1.2
High blood pressure (mother)	1.0	1.3	2.2	-0.3	1.3	-1.5
Body mass index (BMI)	0.2	0.9	2.2	-1.5	-0.0	0.6
Impedance of leg (left)	0.4	1.7	3.1	-1.8	0.7	-1.3
Leg predicted mass (left)	0.1	0.6	1.5	-0.3	-0.5	1.2
Trunk fat mass	0.3	1.3	3.6	-1.9	0.4	0.4
Waist circumference	0.6	2.2	4.8	-2.2	-0.6	1.2
Number of incorrect matches in round	0.1	0.2	0.4	0.0	-0.6	0.4
Past tobacco smoking	0.3	0.6	1.6	-0.4	-1.3	0.0
Alcohol usually taken with meals	0.9	1.4	2.9	1.7	0.1	1.1
Nervous feelings	0.4	0.8	1.2	1.1	-0.8	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	0.4	-0.5	1.2
Hearing difficulty/problems with background noise	0.3	0.5	1.4	0.0	1.2	-0.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.3	-0.7	-0.1	-1.2
Had menopause	0.1	0.1	0.2	-0.3	-0.2	0.5
Had other major operations	0.2	0.2	0.3	-0.4	0.5	0.5
Forced vital capacity (FVC)	0.7	2.8	4.9	0.5	1.8	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	-0.2	-0.0	1.1
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.2	-1.6	1.8	-0.7
Qualifications: None of the above	1.1	2.4	2.7	-1.6	-1.5	1.6
Financial difficulties in last 2 years	1.1	1.5	3.1	-1.8	1.2	-0.2
Mouth/teeth dental problems	0.3	0.5	0.7	0.4	-0.8	0.9
Heart attack	1.6	2.0	3.2	-1.5	-1.8	0.8
Allergy	0.5	1.2	2.9	-1.7	0.4	-0.8
Pain all over the body in last month	1.2	1.2	2.5	1.6	-0.7	0.8
Diabetes (self-reported)	0.4	0.6	0.9	0.7	-0.7	1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.6	-0.1	1.3	-0.7
Medication: Ramipril	1.5	1.9	3.9	-0.6	-2.0	1.2
Medication: Simvastatin	0.2	0.3	0.5	0.6	-0.2	0.7
Fluid intelligence score	0.4	0.9	2.1	0.7	-1.5	0.1
Illnesses of siblings	0.9	1.3	2.0	0.9	1.1	-1.4
Neuroticism score	0.6	1.3	1.4	1.2	-1.0	1.2
Weight	0.2	1.1	2.7	-1.6	-0.0	0.8
Impedance of arm (right)	0.7	3.3	5.9	-0.4	2.0	-2.4
Arm fat percentage (right)	0.2	0.9	2.3	-1.5	0.6	0.1
Trunk fat-free mass	0.2	1.4	2.4	-0.7	-1.2	1.5
Hip circumference	0.2	0.9	2.5	-1.6	0.4	-0.0
Time employed in main current job	1.0	1.2	2.6	-0.4	0.9	-1.6
Alcohol intake versus 10 years previously	0.9	1.3	3.8	-2.0	0.1	0.2
Father’s age at death	0.3	0.4	0.6	0.5	-0.4	0.8
Worrier / anxious feelings	1.1	2.0	4.9	2.2	-0.1	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	-0.8	-0.3	0.6
Falls in the last year	0.7	1.0	1.4	-1.0	-0.8	1.2
Hair/balding pattern: Pattern 3	0.3	0.4	1.2	-1.1	0.1	0.2
Number of live births	0.4	0.6	1.1	-0.8	0.4	-1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.5	-0.4	1.8	-2.1
Pulse rate	1.5	2.6	7.0	-0.7	-0.5	2.6
Happiness	0.3	0.3	0.6	-0.6	0.8	-0.3
Noisy workplace	1.0	1.3	3.2	-1.8	0.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.8	2.2	-0.1	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	0.8	0.5	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	0.8	-0.5	0.1
Asthma	0.2	0.5	0.8	0.9	-0.5	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.6	-2.4	-0.5	0.4
Medication: Cholesterol lowering	0.2	0.3	0.4	0.5	0.3	0.6
Depression (self-reported)	1.5	1.8	3.4	0.0	1.9	-1.4
Medication: Lansoprazole	0.1	0.1	0.4	0.1	-0.6	-0.2
Prospective memory result	0.6	0.7	1.1	0.9	-1.0	0.4
Lung cancer (father)	0.2	0.2	0.7	0.8	0.1	0.1
Illnesses of mother	0.9	1.1	2.8	-0.3	-0.7	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.7	0.1	1.2	-1.9
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.6	0.3	0.8
Impedance of arm (left)	0.5	2.4	4.3	0.1	1.7	-2.1
Arm fat mass (right)	0.2	0.9	2.4	-1.5	0.2	0.6
Trunk predicted mass	0.3	1.5	2.4	-0.8	-1.2	1.6
Standing height	0.0	0.1	0.4	-0.6	0.0	0.1
Length of working week for main job	1.6	1.8	3.1	-0.1	-1.8	1.5
Exposure to tobacco smoke at home	0.8	0.8	1.7	0.1	1.3	-0.9
Breastfed as a baby	0.3	0.4	0.7	-0.7	0.2	0.9
Tense / ‘highly strung’	1.9	3.2	7.3	2.7	-0.9	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.9	-0.5	1.7	-1.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	-0.5	0.6	-0.4
Birth weight of first child	1.3	2.4	3.8	2.0	0.0	1.9
Peak expiratory flow (PEF)	0.2	0.5	0.9	-0.5	1.0	-0.5
Pulse wave reflection index	0.9	1.1	2.3	1.0	0.3	-1.5
Ever highly irritable/argumentative for 2 days	1.7	2.0	3.2	-0.0	1.8	-1.7
Loud music exposure frequency	0.5	0.6	1.6	-0.0	-0.4	1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.4	0.4	0.8	-1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.4	0.1	0.9	-1.2
Blood clot in the leg (DVT)	0.8	1.0	1.1	0.9	-1.0	1.1
Medication: Paracetamol	0.6	0.9	1.9	-0.7	-0.5	1.4
Headache pain in last month	2.0	3.4	4.6	-2.1	1.9	-1.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.9	-1.4	0.6	-1.0
Glaucoma (self-reported)	0.6	0.6	1.2	-1.1	0.7	0.5
Gout (self-reported)	0.4	0.6	1.0	-1.0	0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.6	2.2	0.2	-0.2
Medication: Amlodipine	0.5	0.7	0.8	0.8	-0.8	0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.0	1.0	-0.2	0.9
Birth weight	0.2	0.4	1.3	1.1	0.1	-0.1
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.9	1.0	0.2	-2.0
High blood pressure (siblings)	1.1	1.6	2.5	-0.7	-1.6	1.4
Forced vital capacity (FVC), Best measure	0.7	2.4	4.5	0.7	1.5	-2.1
Body fat percentage	0.4	1.5	4.1	-2.0	0.6	0.2
Leg fat percentage (right)	0.8	3.0	8.7	-3.0	0.6	0.0
Arm fat-free mass (right)	0.6	3.1	4.8	-0.8	-2.0	2.2
Exposure to tobacco smoke outside home	0.4	0.5	1.2	-1.1	-0.4	0.2
Comparative body size at age 10	1.4	3.8	7.4	0.8	-2.7	1.8
Number of full brothers	1.2	1.5	3.1	0.9	1.8	-0.8
Worry too long after embarrassment	0.1	0.1	0.3	-0.1	0.3	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.1	0.1	-0.6
Wheeze or whistling in the chest in last year	0.7	1.3	2.5	-0.4	-1.1	1.6
Number of children fathered	0.6	0.7	1.2	0.9	-1.1	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.7	0.8	-0.3	0.7
Age at first live birth	0.3	0.6	1.5	1.2	-0.5	0.1
Pulse wave peak to peak time	0.2	0.3	0.4	-0.6	-0.3	-0.6
Health satisfaction	3.6	4.7	6.2	-2.3	2.5	-1.6
Shortness of breath walking on level ground	0.9	1.0	2.4	0.5	1.6	-0.6
Qualifications: College or University degree	1.0	3.2	7.6	2.8	-0.7	1.3
Eye problems/disorders: None of the above	1.1	1.3	2.1	0.1	1.3	-1.5
Mouth/teeth dental problems: Loose teeth	1.2	1.5	4.3	0.2	0.3	2.1
Emphysema/chronic bronchitis	0.4	0.5	1.0	1.0	0.5	0.4
Medication for pain relief, constipation, heartburn	1.5	2.5	4.6	2.1	0.9	-1.5
Neck or shoulder pain in last month	0.6	0.9	2.4	-0.0	0.4	-1.5
Medication: Blood pressure	0.0	0.0	0.0	0.1	-0.0	-0.0
Angina (self-reported)	1.0	1.3	3.3	-1.8	0.7	-0.1
Migraine (self-reported)	0.8	1.0	1.6	-0.6	1.0	-1.3
Medication: Ibuprofen	1.0	1.2	3.3	-1.8	-0.1	0.4
Medication: Allopurinol	0.5	0.7	1.2	0.9	0.1	-1.1
Medication: Omeprazole	0.9	1.0	1.7	-0.5	-1.1	1.3
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.3	-0.6	0.1
Mean time to correctly identify matches	0.8	1.5	2.7	-1.6	-1.3	0.4
Heart disease (mother)	0.6	0.8	0.9	-0.8	0.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.7	0.8	0.8	-0.0
Whole body fat mass	0.3	1.2	3.1	-1.8	0.3	0.6
Leg fat mass (right)	0.6	2.1	5.7	-2.4	0.6	0.5
Arm predicted mass (right)	0.5	2.4	3.9	-0.9	-1.6	2.0
Pulse rate, automated reading	4.3	14.0	28.9	-0.8	-3.5	5.4
Alcohol intake frequency.	0.2	0.4	1.3	-1.1	0.2	0.1
Comparative height size at age 10	0.1	0.6	1.4	-0.6	-1.2	0.4
Number of full sisters	1.1	1.3	3.5	-1.9	0.3	0.5
Suffer from ‘nerves’	1.1	1.7	3.6	1.9	-0.9	0.7
Overall health rating	0.6	1.3	2.7	-0.4	-1.0	1.7
Chest pain or discomfort	0.1	0.2	0.3	-0.6	0.4	-0.2
Had major operations	0.1	0.1	0.2	-0.2	-0.5	0.1
Age at last live birth	0.7	1.1	2.6	1.6	-0.6	0.4
Family relationship satisfaction	0.1	0.1	0.4	-0.6	0.1	0.2
Leg pain on walking	0.6	0.8	1.8	-0.2	1.3	-0.7
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.4	3.9	-1.8	1.8	-2.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.4	0.5	0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	0.5	-1.3	-0.2
Medication: Aspirin	0.7	0.9	1.4	-0.3	-1.2	1.1
Supplements: Vitamin C	0.5	0.6	1.3	-1.1	0.4	-0.6
Knee pain experienced in last month	0.4	0.6	1.0	0.6	-1.0	0.6
Hypertension (Self-reported)	0.6	1.6	4.4	-2.1	-0.0	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	7.1	-2.7	-0.2	-0.9
Illnesses of father: Heart disease	0.8	1.1	2.5	0.9	1.6	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.1	-0.3	0.4	0.1
Smoking status: Previous	0.8	1.2	2.7	0.3	1.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	0.2	0.7	-0.0
Whole body fat-free mass	0.2	1.2	2.3	-0.5	-1.1	1.5
Leg fat-free mass (right)	0.1	0.6	1.2	-0.2	-0.8	1.1
Arm fat percentage (left)	0.2	0.8	2.1	-1.4	0.5	0.3
Average weekly red wine intake	0.7	1.0	1.6	1.3	0.2	-1.1
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.8	-0.6	0.8	-1.3
Mood swings	0.3	0.5	1.0	-0.7	0.2	1.0
Loneliness, isolation	0.9	1.3	2.6	0.4	-1.0	1.6
Long-standing illness, disability or infirmity	1.0	1.6	3.0	0.6	-1.2	1.7
Ever had bowel cancer screening	0.1	0.1	0.2	0.5	-0.2	0.3
Diabetes diagnosed by doctor	0.4	0.6	0.9	0.5	-0.8	0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	3.4	1.9	1.8	0.5
Friendships satisfaction	0.7	0.9	2.6	0.1	-0.2	1.6
Qualifications: nursing, teaching	0.8	1.2	3.5	1.9	-0.0	0.1
Commuting to job workplace: Walk	0.4	0.4	0.9	-0.0	0.6	-0.9
Eye problems/disorders: Cataract	1.5	1.7	4.5	-0.1	-0.8	2.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.3	0.8	-0.0
Medication for cholesterol	0.2	0.3	0.6	0.4	0.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.8	-1.3	0.9	-0.1
Back pain experienced in last month	0.5	0.7	1.8	-0.3	1.4	-0.5
Mineral and other dietary supplements	1.1	1.5	2.9	-0.8	1.7	-0.9
Breast cancer (self-reported)	0.4	0.5	0.9	-0.6	0.9	-0.5
Asthma (self-reported)	0.3	0.5	0.8	0.8	-0.4	0.9
Osteoporosis (self-reported)	0.1	0.1	0.2	0.4	0.2	-0.4
Osteoarthritis (self-reported)	0.6	0.8	1.4	0.8	-1.2	0.5
Medication: Aspirin	0.8	1.0	1.6	-0.3	-1.3	1.1
Medication: Gliclazide	3.5	3.9	8.6	2.9	-0.9	1.5
Illnesses of father: None of the above (group 1)	1.8	2.3	3.7	0.3	-1.9	1.7
Smoking status: Current	0.1	0.2	0.5	-0.1	-0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	4.1	0.3	2.0	-1.1
Whole body water mass	0.2	1.3	2.5	-0.5	-1.1	1.6
Leg predicted mass (right)	0.1	0.6	1.3	-0.2	-0.8	1.1
Arm fat mass (left)	0.2	0.8	1.7	-1.3	0.1	0.7
Number of self-reported non-cancer illnesses	0.7	1.2	2.1	-1.0	1.4	-0.7
Average weekly champagne plus white wine intake	0.6	0.8	1.6	1.2	0.8	0.4
Miserableness	0.5	0.8	1.4	0.8	-1.2	0.5
Guilty feelings	1.6	2.5	5.1	0.6	2.3	-1.4
Wears glasses or contact lenses	0.8	0.9	1.1	-1.0	-0.9	0.9
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.6	0.5	0.2
Hearing aid user	0.2	0.2	0.5	0.7	0.1	0.1
Mother’s age at death	2.7	3.4	7.6	-0.5	-2.8	1.5
Financial situation satisfaction	0.3	0.4	0.8	-0.4	0.5	-0.9
Tinnitus: Yes, now most or all of the time	1.5	1.7	2.7	-1.6	1.3	-0.8
Commuting to job workplace: Public transport	0.5	0.6	0.8	-0.5	0.9	-0.9
Eye problems/disorders: Glaucoma	0.7	0.8	1.5	-1.2	0.8	0.5
Medication: Blood pressure	0.2	0.4	0.6	-0.7	-0.8	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	-0.3	-0.1	0.7
Supplements: Fish oil (including cod liver oil)	1.7	2.2	3.9	1.2	-2.0	1.1
High cholesterol (Self-reported)	0.4	0.7	1.0	0.7	-0.7	1.0
Medication: Bendroflumethiazide	0.3	0.5	1.0	-0.5	-0.4	-1.0
Medication: Paracetamol	0.4	0.7	1.2	-0.8	-0.5	1.1
Medication: Lisinopril	1.1	1.5	2.6	-1.2	0.5	-1.6
Medication: Atorvastatin	0.5	0.6	0.9	-1.0	-0.7	0.5
Illnesses of father: High blood pressure	1.0	1.2	2.5	-0.2	1.0	-1.6
Alcohol drinker status: Never	0.6	0.7	1.2	-0.2	-1.1	0.8
Ever smoked	0.5	0.9	1.5	-0.9	1.2	-0.7
Basal metabolic rate	0.2	1.2	2.1	-0.8	-0.9	1.5
Leg fat percentage (left)	0.8	3.0	8.9	-3.0	0.1	-0.0
Arm fat-free mass (left)	0.3	1.7	2.2	-1.3	-1.1	1.5
Number of operations (self-reported)	0.5	0.7	1.4	-1.2	-0.4	0.8
Average weekly beer plus cider intake	0.4	0.6	0.9	-0.9	-0.3	-0.9
Irritability	0.8	1.3	1.8	0.6	-1.4	1.3
Risk taking	0.5	0.8	2.3	0.2	-0.1	1.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	0.7	-0.7	-0.3
Fractured/broken bones in last 5 years	2.0	2.6	3.1	1.6	-1.8	1.5
Age started oral contraceptive pill	1.4	1.8	3.8	-1.9	-0.8	-0.9
Diastolic blood pressure, automated reading	0.9	2.9	5.7	-1.4	1.0	-2.4
Ever depressed for a whole week	1.1	1.4	2.0	-1.3	1.4	-0.8
Unable to work because of sickness or disability	1.2	1.6	3.5	-0.1	-1.1	1.9
Commuting to job workplace: Cycle	0.4	0.5	1.4	-0.2	-1.2	0.0
Myopia	3.3	4.7	5.8	2.1	-2.0	2.4
Vascular/heart problems diagnosed by doctor	0.9	2.4	5.3	2.3	-0.3	1.3
Cholesterol lowering medication	0.2	0.3	0.7	-0.3	-0.8	0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.0	-0.6	-1.0	0.8
Pain experienced in last month	1.1	1.8	3.7	0.3	-1.9	1.2
Supplements: Calcium	1.0	1.1	3.2	-1.8	-0.2	0.1
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	-0.6	-0.7	0.0
Heart attack/myocardial infarction (self-reported)	1.4	1.9	3.1	-1.4	-1.8	0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	0.8	0.7	-0.9	0.9
Heart disease (siblings)	0.2	0.2	0.5	0.1	0.2	0.7
Alcohol drinker status: Previous	0.7	0.8	1.8	-0.3	1.4	-0.7
Pack years of smoking	0.2	0.3	0.7	0.2	0.8	-0.4
Impedance of whole body	0.4	2.0	3.4	-0.7	1.5	-1.8
Leg fat mass (left)	0.5	2.0	5.4	-2.3	0.3	0.6
Arm predicted mass (left)	0.4	1.9	2.1	-1.4	-1.3	1.4