TWAS hub - ASAP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1790	0.0465	1.7e-06	0.055	NA	0.139	NA	0.121	4.2e-05	NA	4.9e-11	NA	1.1e-09
2	GTEx	Cells Transformed fibroblasts	0.2010	0.0440	2.6e-08	0.105	NA	0.157	NA	0.144	2.9e-08	NA	8.2e-12	NA	5.8e-11
3	GTEx	Thyroid	0.1180	0.0470	4.4e-03	-0.003	NA	0.003	NA	-0.004	6.4e-01	NA	1.6e-01	NA	9.5e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.0474	0.0174	2.9e-04	0.041	0.025	0.042	0.036	0.044	4.4e-06	2.8e-04	3.3e-06	1.8e-05	2.3e-06
5	TCGA	Breast Invasive Carcinoma	0.0944	0.0489	2.1e-04	0.040	0.023	0.039	NA	0.038	1.3e-08	1.3e-05	1.4e-08	NA	2.3e-08
6	TCGA	Colon Adenocarcinoma	0.0580	0.0330	7.0e-03	-0.003	0.005	-0.002	NA	-0.002	5.3e-01	1.6e-01	4.5e-01	NA	4.2e-01
7	TCGA	Esophageal Carcinoma	0.1540	0.0760	8.8e-03	-0.008	0.007	-0.009	NA	-0.008	7.3e-01	1.8e-01	9.4e-01	NA	7.7e-01
8	TCGA	Prostate Adenocarcinoma	0.0718	0.0400	3.1e-04	0.035	0.027	0.012	NA	0.020	1.2e-04	6.7e-04	1.7e-02	NA	2.8e-03
9	TCGA	Thyroid Carcinoma	0.0510	0.0210	2.7e-06	0.054	0.062	0.065	NA	0.057	5.9e-06	1.1e-06	6.3e-07	NA	3.2e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Commuting to job workplace: Public transport	8.9	10.6	19.2	1.7	3.6	2.6	-1.1	4.2	4.0	1.1	4.4	4.2
Commuting to job workplace: Car/motor vehicle	5.0	5.7	12.4	-2.8	-2.2	-1.3	1.2	-2.4	-3.5	-2.3	-2.4	-2.5
Alzheimer’s Disease (including proxy)	3.9	5.6	16.9	4.1	1.5	2.7	-0.9	1.2	2.9	3.2	1.8	0.8
Number of live births	3.8	5.4	10.1	-1.5	-3.1	-1.2	0.7	-2.9	-2.7	-0.4	-3.2	-2.9
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	7.7	2.7	2.4	1.6	-0.1	1.8	2.8	1.6	2.7	2.3
Commuting to job workplace: Walk	3.5	3.7	6.2	1.6	2.1	1.3	-0.6	2.3	2.4	1.7	2.5	2.2
Alzheimer’s Disease (in father)	3.4	3.7	11.6	3.4	1.3	2.8	-0.6	-0.1	2.3	1.6	1.1	1.5
Hand grip strength (right)	3.1	8.3	14.2	-2.6	-2.8	-1.9	2.9	-3.1	-3.8	-3.0	-2.9	-2.8
Lung FEV1/FVC ratio	3.0	15.1	83.0	9.1	-0.1	0.2	-1.8	-0.4	4.0	5.7	-1.2	-0.4
Hand grip strength (left)	3.0	8.0	12.8	-2.0	-3.1	-2.1	2.4	-2.9	-3.6	-2.0	-3.5	-3.3
Rheumatoid Arthritis	2.9	4.0	8.2	-1.1	-1.4	0.3	1.9	-2.8	-2.1	-2.9	-2.7	-1.1
Hayfever/allergic rhinitis (self-reported)	2.8	3.7	6.7	1.7	2.1	0.7	-1.4	1.6	2.6	1.8	2.2	2.4
Medication: Paracetamol	2.8	4.7	9.6	2.2	1.5	1.2	-3.1	1.4	3.0	2.2	1.1	2.5
Supplements: Fish oil (including cod liver oil)	2.8	3.7	5.0	-2.0	-2.2	-2.0	0.5	-2.2	-2.2	-0.7	-2.1	-2.2
Triglycerides	2.7	4.4	7.6	1.5	1.4	0.5	-2.3	2.3	2.8	2.3	2.4	2.5
Father’s age at death	2.5	3.3	6.5	-2.0	-0.9	-1.6	2.0	-1.1	-2.4	-2.6	-2.0	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.7	6.5	-2.5	-1.2	-0.5	0.4	-2.5	-1.8	-2.2	-1.2	-0.6
Tense / ‘highly strung’	2.4	4.0	6.6	0.6	2.3	1.1	-2.5	2.2	2.0	0.8	2.5	2.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.4	16.7	0.2	-3.4	-3.1	0.1	-4.0	-2.1	-0.5	-4.1	-2.8
Illnesses of father: High blood pressure	2.3	2.9	5.2	-1.1	-1.9	0.1	1.4	-2.0	-2.3	-1.8	-2.0	-1.7
Diastolic blood pressure, automated reading	2.3	7.2	21.0	4.2	1.5	0.4	-2.4	2.2	3.4	4.6	0.9	0.7
Forced vital capacity (FVC), Best measure	2.2	7.9	13.5	-2.4	-3.1	-3.2	0.7	-3.7	-3.1	-2.1	-3.4	-2.5
Heart disease (mother)	2.2	2.7	8.5	2.8	-0.6	0.6	0.3	0.8	0.4	2.9	-0.7	-2.4
Mineral and other dietary supplements	2.2	2.9	7.2	0.9	2.7	1.1	-0.6	1.6	2.0	0.3	2.2	2.3
Birth weight	2.1	4.5	9.0	-0.4	-3.0	-1.7	-2.5	-2.0	-1.0	2.6	-1.7	-2.9
Supplements: Calcium	2.1	2.4	5.7	0.5	-1.3	-1.3	-2.1	-2.1	-0.2	1.3	-2.4	-1.3
Alcohol usually taken with meals	2.0	3.3	7.7	-1.5	-0.9	-0.5	1.5	-2.8	-2.3	-1.8	-2.1	-1.8
Forced vital capacity (FVC)	2.0	7.8	11.4	-2.1	-3.3	-3.1	1.1	-3.4	-3.3	-2.1	-3.0	-2.9
Had major operations	2.0	2.3	8.1	2.6	0.1	-0.1	-1.0	1.4	1.6	2.8	0.4	-0.2
Medication: Aspirin	2.0	2.6	6.3	-1.8	-1.9	-1.5	-0.6	-0.3	-2.2	0.1	-1.5	-2.5
Friendships satisfaction	2.0	2.5	6.4	1.6	1.1	0.2	-2.0	1.4	2.5	1.1	0.6	2.2
Commuting to job workplace: Cycle	2.0	2.4	6.8	-1.4	-0.5	-0.2	1.4	-2.6	-1.5	-2.5	-1.4	-0.1
Bipolar Disorder (2011)	1.9	1.9	8.1	0.6	0.5	-0.2	-2.8	0.0	1.8	1.2	0.4	1.8
Supplements: Zinc	1.9	2.1	6.8	0.2	-2.6	-0.4	0.4	-1.3	-1.3	-0.0	-2.4	-1.6
Medication: Co-codamol	1.9	2.2	6.5	1.2	1.3	-0.1	-2.5	1.6	1.5	1.9	0.9	0.9
Happiness	1.9	2.3	4.8	1.6	0.3	0.8	-1.9	2.0	1.8	2.2	1.0	0.7
Peak expiratory flow (PEF)	1.9	4.5	7.8	2.7	-2.4	-1.1	1.8	-2.5	-1.3	0.3	-2.8	-2.7
Family relationship satisfaction	1.9	2.4	4.7	1.6	1.3	0.6	-1.2	2.2	1.9	1.8	1.7	1.1
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	10.7	-1.1	-0.8	-0.1	0.8	-3.3	-1.1	-2.1	-1.3	-0.2
Waist Hip Ratio (WHR)	1.8	8.1	25.3	1.8	1.5	-0.3	-5.0	1.8	3.6	4.3	1.8	2.1
Medication for pain relief, constipation, heartburn	1.8	3.1	6.5	-1.6	-1.2	-0.6	2.5	-1.6	-2.3	-2.2	-1.2	-1.6
Ever had bowel cancer screening	1.8	2.2	5.5	0.7	0.9	0.9	-2.4	1.6	1.9	1.9	0.9	1.1
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	5.7	0.4	-2.4	0.2	-0.0	-2.2	-1.1	0.5	-2.4	-1.8
Eye problems/disorders: None of the above	1.7	1.9	5.3	1.1	2.2	-0.8	0.8	2.3	0.9	0.3	1.7	1.0
Medication: Ibuprofen	1.7	2.0	3.7	1.2	1.9	1.6	0.3	1.1	1.5	0.0	1.7	1.9
Irritability	1.7	3.0	7.8	0.6	2.3	-0.0	-0.4	2.8	1.9	0.2	2.1	2.2
Hearing difficulty/problems: Yes	1.6	2.4	5.0	0.5	1.1	1.4	-1.4	1.9	1.8	0.6	2.2	2.0
Forced expiratory volume in 1-second (FEV1)	1.6	5.3	11.0	0.4	-3.0	-2.5	0.6	-3.3	-2.0	-0.5	-3.1	-2.6
Length of working week for main job	1.6	1.7	6.8	1.8	-0.4	1.0	-1.5	0.0	0.8	2.6	-0.0	-1.2
Alcohol drinker status: Never	1.6	1.9	4.2	-0.5	-2.0	-0.8	1.0	-0.7	-1.9	-1.2	-2.0	-1.2
Number of operations (self-reported)	1.6	2.3	8.2	2.7	-1.2	-0.0	-1.0	0.7	1.3	2.9	0.4	-0.7
Myopia	1.6	2.3	6.1	2.1	2.5	-0.4	0.9	1.5	1.3	1.1	1.9	0.7
Coronary Artery Disease (CAD)	1.5	1.8	3.9	0.2	-2.0	-1.6	-1.0	-1.9	-0.9	1.0	-1.3	-1.3
Had other major operations	1.5	1.8	6.8	2.6	-0.9	-0.2	-0.3	-0.4	1.0	2.5	-0.3	-1.1
Financial difficulties in last 2 years	1.5	2.1	4.3	1.4	0.2	1.1	-2.1	1.9	1.6	1.7	1.0	1.0
Pulse rate, automated reading	1.5	4.8	11.7	-0.5	3.3	1.2	1.9	3.4	0.7	-1.9	2.2	2.6
Age at last live birth	1.5	2.2	6.8	-2.5	-0.5	-1.4	1.3	-0.4	-1.5	-2.6	-0.5	-0.0
Medication: Paracetamol	1.5	2.4	5.2	1.9	1.1	1.3	-2.3	0.7	2.0	1.7	0.5	1.5
Heart disease (siblings)	1.5	1.8	6.6	0.6	-1.0	-1.2	-1.0	0.1	-0.7	2.3	-0.6	-2.6
Waist circumference	1.4	5.2	9.2	2.7	1.8	0.8	-2.0	2.6	3.0	2.7	1.8	2.2
Medication: Ventolin 100micrograms inhaler	1.4	1.8	5.7	-1.8	-0.6	-0.7	1.9	-0.7	-1.3	-2.4	-0.5	0.4
Alzheimer’s Disease (in mother)	1.3	1.5	3.1	1.7	0.8	1.0	0.3	1.1	1.2	1.8	1.8	0.2
Body Mass Index (BMI) (2010)	1.3	1.8	3.7	1.1	1.5	0.5	-1.3	0.9	1.9	1.4	1.4	1.6
Average weekly spirits intake	1.3	1.6	6.1	1.5	-0.4	0.5	1.4	-0.0	-0.5	1.8	-0.4	-2.5
Medication: Atenolol	1.3	1.6	4.8	0.3	0.4	0.6	-2.2	1.6	1.5	0.8	0.9	1.8
Hearing difficulty/problems with background noise	1.3	2.1	5.2	-1.2	1.4	1.6	-1.3	1.0	1.3	-0.3	1.9	2.3
Blood clot in the leg (DVT)	1.3	1.6	4.2	0.5	-1.9	0.3	-0.3	-1.9	-0.7	0.6	-2.0	-1.4
Medication: Seretide 50 evohaler	1.3	1.5	2.8	-1.4	-1.2	-0.1	1.7	-1.1	-1.4	-1.6	-0.9	-0.8
Eye problems/disorders: Cataract	1.3	1.5	4.9	1.8	-0.5	1.4	-0.3	-2.2	0.9	0.5	-1.3	0.3
Hearing aid user	1.3	1.5	5.9	0.8	0.7	1.4	-0.1	2.4	0.8	-0.1	1.6	1.1
Risk taking	1.3	1.9	6.4	-1.2	-2.5	-0.6	-1.3	-1.0	-1.5	-0.5	-1.4	-1.4
Alcohol drinker status: Previous	1.3	1.5	3.2	0.6	1.2	1.3	-1.8	1.7	1.1	1.1	1.1	0.8
Bipolar Disorder (2018)	1.2	1.9	9.2	-0.3	0.7	-0.2	-3.0	1.8	1.0	1.4	0.5	0.8
Major Depression (MDD)	1.2	1.4	3.3	-0.1	-1.8	-0.6	-0.4	-1.2	-1.3	0.3	-1.6	-1.8
Verbal and Numeric Reasoning (VNR)	1.2	3.0	8.4	1.5	2.1	1.9	2.4	0.9	1.0	0.7	2.9	0.5
Prostate Cancer	1.2	1.7	7.9	-1.9	-0.5	0.1	0.3	-0.9	-0.9	-2.8	-0.9	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	3.3	1.7	1.4	0.8	0.2	1.2	1.5	-0.3	1.1	1.8
High blood pressure (mother)	1.2	1.7	8.0	-0.8	-0.1	0.4	2.8	-0.1	-1.8	-1.6	0.2	-0.9
Arm fat percentage (right)	1.2	4.8	8.3	2.9	2.1	2.5	0.1	2.8	2.5	0.8	1.8	2.4
Medication: Lansoprazole	1.2	1.4	4.6	1.3	0.8	1.3	0.5	2.1	0.6	1.2	1.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	6.2	0.5	-1.7	-1.7	1.2	-1.9	-1.2	0.5	-1.7	-2.5
Average weekly champagne plus white wine intake	1.2	1.6	6.7	-1.3	-0.3	-2.6	-0.6	-1.7	-0.8	-1.0	-1.2	-0.1
Guilty feelings	1.2	1.8	9.2	-3.0	-0.3	-0.7	-0.1	-0.1	-1.5	-2.0	-0.5	-0.0
Ever taken oral contraceptive pill	1.2	1.3	3.3	-1.8	-1.2	0.2	0.9	0.5	-1.8	-0.7	-0.4	-1.5
Ever had hysterectomy (womb removed)	1.1	1.2	4.0	0.3	-1.1	-0.6	-1.7	-0.3	-0.1	2.0	-0.8	-1.1
Supplements: Glucosamine	1.1	1.4	3.0	-0.3	-1.7	-0.7	1.4	-1.0	-1.3	-0.8	-1.4	-1.4
Hair/balding pattern: Pattern 2	1.1	1.4	3.2	0.9	1.8	0.0	0.3	1.7	0.9	-0.0	1.7	1.5
Illnesses of mother	1.1	1.4	6.4	-0.3	0.5	0.9	-2.5	-0.5	1.0	-0.1	0.3	1.8
Supplements: Vitamin C	1.1	1.3	3.5	-0.6	-1.9	-1.2	-0.5	-0.3	-1.3	0.7	-0.8	-1.9
Arm fat percentage (left)	1.1	4.4	8.6	2.5	2.0	2.5	0.0	2.9	2.3	0.7	1.8	2.3
Handedness (chirality/laterality): Left-handed	1.1	1.3	4.4	-1.4	0.7	-0.7	1.7	0.8	-0.7	-2.1	0.3	0.8
Breast cancer (self-reported)	1.1	1.3	2.9	-0.2	-1.3	-0.4	1.2	-0.6	-1.6	-0.8	-1.5	-1.7
Osteoporosis (self-reported)	1.1	1.3	4.7	0.4	-1.6	-0.2	-0.3	-0.5	-0.8	1.1	-1.6	-2.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.5	0.4	-1.5	-1.3	-1.1	-0.9	-0.3	1.2	-1.6	-1.5
Pack years of smoking	1.1	1.6	5.6	2.4	0.2	0.4	0.2	1.6	1.2	2.0	0.4	-0.3
Ovarian Cancer	1.0	1.3	3.9	-0.8	-1.1	-2.0	-0.8	0.1	-0.9	0.6	-1.5	-1.5
Mean Putamen Volume	1.0	1.1	2.9	-1.7	1.1	0.4	1.1	-1.1	-1.3	-1.0	0.7	-0.8
Schizophrenia (2014)	1.0	2.1	4.1	-1.7	-1.2	-1.1	-2.0	-0.0	-1.7	0.9	-1.5	-1.9
Hypothyroidism (self reported)	1.0	2.4	6.7	-1.8	-0.3	0.4	2.6	0.4	-2.0	-2.1	-0.1	-1.5
Number of treatments/medications taken	1.0	1.8	6.3	1.4	0.0	0.2	-2.5	0.9	1.2	2.3	0.3	-0.0
Pack years adult smoking proportion	1.0	1.5	6.2	2.5	0.0	0.4	0.6	1.4	1.1	1.7	0.3	-0.3
Trunk fat percentage	1.0	4.0	9.5	3.1	1.6	2.2	-0.7	2.2	2.5	1.2	1.3	2.1
Multivitamins +/- minerals	1.0	1.3	2.9	-0.7	-1.6	-0.3	-0.2	-1.7	-1.2	0.6	-1.1	-1.7
Had menopause	1.0	1.2	6.6	1.2	-0.6	0.1	2.6	-0.4	-0.7	-0.5	-0.3	-1.2
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	3.9	0.8	-1.1	-0.2	-1.9	0.2	0.6	2.0	-0.9	-0.9
Fluid intelligence score	1.0	2.2	7.9	0.1	1.2	2.0	2.8	0.9	-0.4	-1.1	2.0	0.2
Depression (self-reported)	1.0	1.2	3.3	-0.5	1.2	1.3	-1.8	1.2	0.6	-0.1	0.8	1.2
Body fat percentage	1.0	4.0	9.9	3.1	1.6	1.9	-0.5	2.4	2.5	1.3	1.3	2.1
Number of self-reported non-cancer illnesses	1.0	1.7	8.8	0.2	-0.3	0.5	-3.0	1.5	0.8	1.9	-0.4	0.5
Eye problems/disorders: Glaucoma	1.0	1.2	2.4	-1.4	-1.3	-1.5	-0.5	-0.6	-1.2	0.3	-0.9	-1.5
Medication: Bendroflumethiazide	1.0	1.5	3.6	0.2	1.9	1.8	0.6	1.0	0.6	-0.1	1.8	1.3
Basal cell carcinoma (self-reported)	1.0	1.2	3.4	-1.8	-0.5	-1.1	1.3	-0.0	-1.3	-0.6	0.7	-1.1
Age at First Birth	0.9	1.3	5.0	-1.8	-0.3	-1.3	0.0	-0.0	-0.6	-2.2	-1.1	0.7
Smoking Status	0.9	2.1	5.2	1.0	-2.0	-2.0	0.3	-0.8	-1.0	1.0	-1.4	-2.3
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.1	-0.5	-1.8	-0.8	-1.4	-0.0	-0.9	0.2	-1.4	-1.2
Qualifications: CSEs or equivalent	0.9	1.2	4.6	0.8	-1.1	-0.9	0.7	-2.1	-0.8	-0.7	-1.1	-0.8
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.1	1.8	-1.0	0.1	-0.9	-1.5	0.4	1.2	-1.0	-0.4
Heart attack	0.9	1.1	2.2	0.7	-1.0	-1.2	-1.5	-0.3	0.1	1.5	-1.2	-1.1
Pain all over the body in last month	0.9	1.0	3.5	0.6	1.9	0.5	-0.2	-0.2	1.1	0.0	1.1	1.4
Hair/balding pattern: Pattern 3	0.9	1.4	4.1	1.0	-1.1	0.7	0.3	-1.2	-0.3	1.6	-1.3	-2.0
Neck or shoulder pain in last month	0.9	1.3	6.7	2.6	-0.6	-0.0	-0.4	-0.6	0.8	1.5	-0.9	-0.6
Number of full sisters	0.9	1.1	4.0	-0.1	-0.6	0.5	-2.0	-0.0	0.2	1.9	-0.5	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.4	1.5	0.4	0.7	-0.8	1.5	1.1	1.5	0.1	0.2
Medication: Aspirin	0.9	1.2	3.0	-1.4	-1.1	-0.9	-0.9	0.1	-1.5	0.4	-0.7	-1.7
Medication: Blood pressure	0.9	1.7	8.2	-0.1	1.1	2.9	1.7	0.8	-0.4	-0.7	1.2	0.0
Unable to work because of sickness or disability	0.9	1.2	3.0	1.7	-0.4	0.3	-1.3	0.4	0.5	1.7	-1.0	-1.0
Ulcerative Colitis (UC)	0.8	1.5	7.3	0.2	0.7	0.0	-1.6	0.2	1.2	-1.1	0.7	2.7
Allergy or Eczema	0.8	2.2	6.0	2.4	1.3	1.0	-0.5	-0.9	2.0	1.7	1.4	1.2
Hayfever, allergic rhinitis or eczema	0.8	1.8	5.1	2.3	0.6	0.9	-0.2	0.9	1.9	1.4	1.5	1.1
Body mass index (BMI)	0.8	3.3	6.3	2.5	1.4	1.1	-0.8	2.5	2.3	1.8	1.4	1.7
Number of incorrect matches in round	0.8	1.3	3.7	-0.8	1.3	1.0	-1.9	1.3	0.7	0.5	1.1	1.2
Mouth/teeth dental problems	0.8	1.3	4.2	-1.4	-1.0	-0.6	0.9	-2.0	-1.2	-0.2	-0.5	-1.3
Arm fat mass (right)	0.8	3.3	7.0	2.6	1.5	1.4	-0.4	2.1	2.4	1.5	1.5	1.9
Pulse wave reflection index	0.8	1.0	3.0	1.7	0.7	-0.4	0.3	0.5	0.5	1.7	0.1	-1.3
High blood pressure (siblings)	0.8	1.1	2.7	-0.3	-0.3	-1.3	0.9	-0.5	-1.6	-0.5	-1.2	-1.6
Leg fat percentage (right)	0.8	2.9	7.8	2.8	1.4	1.0	-0.2	2.3	2.1	1.2	0.8	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	4.4	0.5	0.6	2.1	-0.7	1.4	0.9	0.5	0.9	0.8
Shortness of breath walking on level ground	0.8	0.9	3.5	-1.9	-0.2	0.6	-0.5	-0.3	-0.3	-1.6	0.0	1.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.9	-0.2	0.7	0.6	-1.7	1.2	0.8	-0.4	1.0	1.5
Medication: Allopurinol	0.8	1.0	2.5	0.1	1.1	-0.9	-1.0	1.6	1.0	1.2	1.1	0.6
Medication: Omeprazole	0.8	1.0	4.0	0.6	-0.3	0.3	-2.0	0.9	1.2	1.0	0.1	1.1
Illnesses of father: Heart disease	0.8	1.2	5.8	-0.7	-0.4	-0.6	1.0	0.1	-1.5	0.7	-0.1	-2.4
Loneliness, isolation	0.8	1.1	3.6	1.6	0.4	0.9	-1.3	0.3	1.1	1.9	0.5	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.4	1.2	1.3	1.8	-0.2	0.9	1.2	0.3	1.1	1.4
Wears glasses or contact lenses	0.8	1.0	2.7	0.3	1.3	-0.1	0.6	1.6	0.9	-0.1	1.2	1.2
Mother’s age at death	0.8	1.0	2.9	-0.4	-0.8	-1.0	1.7	-0.2	-1.3	-0.8	-0.8	-1.2
Leg fat percentage (left)	0.8	2.9	7.5	2.7	1.3	1.0	-0.5	2.5	2.0	1.4	0.8	1.6
Age started oral contraceptive pill	0.8	1.0	2.9	-1.5	0.2	0.8	0.8	0.1	-1.5	0.3	0.7	-1.7
Bipolar Disorder or Schizophrenia	0.7	1.8	10.4	-1.2	-0.1	-0.5	-3.2	0.9	-0.5	1.4	-0.9	-0.7
Schizophrenia (2018)	0.7	1.5	2.9	-1.5	-0.9	-0.5	-1.7	-0.3	-1.5	0.4	-1.4	-1.6
Schizophrenia vs Biploar Disorder	0.7	0.9	3.2	-0.2	-1.1	-0.1	0.9	0.1	-1.4	-0.0	-0.8	-1.8
Fasting Glucose	0.7	0.8	2.3	1.5	-0.3	-1.5	0.1	-1.0	0.6	0.3	-1.0	0.4
BMI	0.7	3.9	11.3	3.4	1.7	1.8	-0.4	1.1	2.7	1.9	1.3	1.8
Sensitivity / hurt feelings	0.7	1.2	2.6	-1.0	-1.1	-0.2	1.0	-0.9	-1.6	-1.0	-1.0	-1.5
Medication: Metformin	0.7	1.0	3.3	1.4	0.7	0.3	0.8	1.8	0.7	1.1	1.0	0.1
Current tobacco smoking	0.7	1.1	3.7	1.2	-1.3	-0.5	0.6	0.4	-0.9	0.7	-1.2	-1.9
Trunk fat mass	0.7	3.2	8.4	2.9	1.2	1.4	-0.9	1.9	2.4	1.6	1.1	1.8
Medication: Ramipril	0.7	0.9	2.6	-0.4	1.6	1.1	1.1	-1.0	0.2	-0.7	0.8	0.7
Time employed in main current job	0.7	0.8	2.7	-0.5	-1.0	0.6	-0.5	-1.6	-0.1	-1.3	-0.9	0.6
Noisy workplace	0.7	0.9	2.0	1.3	-0.0	1.0	-0.8	0.9	1.1	1.4	0.3	0.4
Breastfed as a baby	0.7	0.9	2.5	1.1	0.5	-0.5	-0.2	0.9	1.1	1.6	1.4	0.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.4	0.9	-0.4	-0.7	-1.6	0.9	1.1	0.6	0.0	0.9
Exposure to tobacco smoke outside home	0.7	0.9	3.1	-1.4	0.5	-0.3	0.9	-1.8	-0.5	-1.2	-0.1	0.3
Worry too long after embarrassment	0.7	1.2	3.1	0.1	-0.9	-1.0	1.7	-1.1	-1.1	-0.2	-0.8	-1.8
Pulse wave peak to peak time	0.7	0.8	2.8	0.9	-1.7	0.6	-0.4	-1.2	0.1	0.2	-1.0	0.2
Emphysema/chronic bronchitis	0.7	0.8	2.4	-1.6	-0.9	-1.4	-1.0	-0.5	-0.7	-0.1	-0.6	-0.5
Whole body fat mass	0.7	3.1	7.2	2.7	1.3	1.2	-0.8	2.1	2.3	1.6	1.2	1.8
Knee pain experienced in last month	0.7	1.1	3.6	0.2	-1.2	-0.3	-0.5	-1.0	-1.0	0.3	-1.4	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.4	0.9	-0.3	-0.3	-1.8	-1.0	0.9	0.8	-0.2	0.6
Smoking status: Current	0.7	1.1	2.9	1.2	-1.5	-0.5	0.2	0.1	-0.7	0.8	-1.3	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.4	1.7	-1.1	-1.9	0.1	-1.7	0.1	0.8	-1.5	-0.8
Arm fat mass (left)	0.7	3.1	5.7	2.4	1.3	1.6	-0.5	2.2	2.2	1.4	1.5	1.8
Miserableness	0.7	1.2	4.4	-1.0	0.6	-1.2	1.7	0.2	-0.8	-2.1	0.2	0.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	4.4	-0.2	0.1	-1.0	-2.1	0.7	0.6	0.8	0.1	0.9
Pain experienced in last month	0.7	1.1	5.2	-2.3	0.4	-1.1	0.8	0.4	-0.9	-1.0	0.9	0.2
Irritable Bowel Disease (IBD)	0.6	1.3	5.1	0.3	0.9	0.2	-2.2	-0.2	1.4	-0.2	0.5	1.9
Breast Cancer	0.6	1.5	3.5	-0.6	-1.2	-1.9	-0.0	-0.9	-1.5	0.1	-1.4	-1.8
HDL Cholesterol	0.6	0.9	3.1	-0.7	-0.1	0.1	1.1	-1.0	-1.2	-1.8	-0.9	-0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.2	5.4	2.3	-0.7	-0.5	0.7	0.4	0.2	1.4	-0.8	-1.1
Lung FVC	0.6	3.0	7.2	-1.8	-1.3	-1.5	1.4	-1.5	-2.2	-2.7	-1.8	-0.9
Systolic blood pressure, automated reading	0.6	1.9	4.9	0.2	2.2	0.3	-0.7	2.2	1.3	0.7	1.6	1.3
Vitamin and mineral supplements	0.6	0.8	2.2	0.2	1.5	0.0	0.8	0.5	0.7	-1.1	0.7	1.4
Fed-up feelings	0.6	1.1	3.1	1.3	1.4	0.4	-0.1	-0.1	1.4	-0.5	0.9	1.8
Medication: Levothyroxine sodium	0.6	1.0	3.5	0.3	0.2	1.9	1.2	1.6	-0.1	-0.1	1.1	-0.6
Diabetes (self-reported)	0.6	1.0	4.3	2.1	-0.1	0.3	-0.3	0.8	1.0	1.6	0.1	-0.1
Illnesses of siblings	0.6	0.8	2.7	-1.6	-0.2	1.3	0.3	-0.3	-0.0	-1.3	0.1	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.3	0.9	0.6	0.9	-0.5	1.5	1.4	0.7	1.5	0.6
Asthma	0.6	1.1	3.4	-0.9	1.3	1.8	-0.9	0.9	0.2	-0.2	0.9	1.2
Medication: Cholesterol lowering	0.6	0.9	3.5	0.4	-0.8	-0.4	-1.4	-0.3	-0.1	1.9	-0.7	-1.0
Pulse wave Arterial Stiffness index	0.6	0.7	2.1	-1.0	1.4	-0.8	0.3	1.1	-0.2	-0.1	1.0	-0.3
Exposure to tobacco smoke at home	0.6	0.7	2.3	0.8	1.4	-0.4	-0.4	0.2	1.1	0.1	0.1	1.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.6	-0.2	-0.4	-1.6	0.2	-1.1	-0.7	0.4	-0.6	-1.2
Health satisfaction	0.6	0.7	2.9	1.0	0.1	-0.1	-1.1	-0.3	0.2	1.7	-0.2	-1.1
Qualifications: College or University degree	0.6	1.7	8.7	-0.3	-0.7	0.8	0.6	-2.9	-1.3	-1.0	-1.4	-0.9
Leg fat mass (right)	0.6	2.1	6.4	2.5	1.0	0.7	-0.5	1.7	1.9	1.6	0.8	1.3
Alcohol intake frequency.	0.6	1.5	3.9	1.3	0.8	0.2	-1.2	2.0	1.4	0.1	0.4	1.9
Mood swings	0.6	1.1	3.2	-0.5	1.1	0.2	0.2	1.4	0.6	-1.4	1.1	1.8
Medication for cholesterol	0.6	0.9	5.0	0.2	-0.6	-2.2	-0.6	-1.1	0.2	0.6	-0.6	-0.2
Back pain experienced in last month	0.6	0.8	1.7	1.0	-1.3	1.2	-0.4	0.3	-0.4	0.2	-1.3	-1.1
Financial situation satisfaction	0.6	0.7	2.7	1.4	-0.4	0.3	-0.8	-0.2	0.4	1.6	-0.3	-1.0
Ulcerative Colitis	0.5	0.7	2.5	0.4	0.5	0.3	-1.6	0.7	0.9	0.0	0.8	1.4
Diabetes (mother)	0.5	0.7	4.9	0.2	0.0	-0.5	0.5	2.2	0.2	-0.1	0.6	0.2
Taking other prescription medications	0.5	0.8	2.1	-0.2	-1.5	-0.6	-1.3	1.2	-0.3	0.7	-0.5	-1.0
Chronic bronchitis/emphysema (father)	0.5	0.6	2.1	0.0	1.3	0.1	-0.9	0.1	0.8	-0.3	0.1	1.5
Nervous feelings	0.5	1.0	2.6	-0.1	1.5	-0.4	-0.2	1.6	0.5	-0.3	1.4	1.2
Qualifications: None of the above	0.5	1.1	2.8	-1.5	-1.0	-0.2	-0.4	-0.6	-0.9	-1.5	-1.7	0.0
Falls in the last year	0.5	0.7	2.7	0.6	0.3	1.6	-1.2	0.5	0.7	0.5	0.3	0.9
Lung cancer (father)	0.5	0.6	1.8	0.3	1.2	0.7	-1.3	-0.1	0.8	0.3	0.1	0.9
Glaucoma (self-reported)	0.5	0.6	1.9	-1.0	-0.5	-1.4	-0.6	0.1	-0.7	0.5	-0.2	-1.0
Number of full brothers	0.5	0.6	3.8	0.3	-0.3	1.9	-0.4	-1.0	-0.2	0.2	-0.3	-0.4
Wheeze or whistling in the chest in last year	0.5	1.0	2.0	-0.9	0.5	1.3	1.1	1.4	-0.6	-0.9	1.2	0.2
Age at first live birth	0.5	0.9	2.8	-0.9	0.1	-1.4	1.5	0.4	-0.5	-1.7	-0.1	0.3
Mean time to correctly identify matches	0.5	0.9	5.9	-0.7	0.4	0.0	-2.4	-0.1	0.7	0.1	-0.2	1.0
Overall health rating	0.5	1.0	2.8	1.7	0.6	0.5	-1.1	1.2	1.0	1.3	0.3	0.2
Leg pain on walking	0.5	0.6	2.1	0.4	-0.0	1.0	-1.5	-0.5	0.9	0.3	-0.3	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	3.0	-0.9	0.1	0.4	-1.7	0.8	0.4	0.2	0.0	0.6
Long-standing illness, disability or infirmity	0.5	0.8	2.2	0.4	-1.4	-0.8	-1.5	0.1	0.2	0.8	-1.1	-0.4
Qualifications: nursing, teaching	0.5	0.7	2.7	0.5	-0.9	-0.5	1.6	0.4	-0.7	-0.2	0.1	-1.3
Asthma (self-reported)	0.5	1.0	2.9	-0.6	1.3	1.7	-1.1	0.9	0.4	0.1	0.9	1.2
Osteoarthritis (self-reported)	0.5	0.6	2.1	-0.2	-1.2	0.2	-1.5	-1.0	0.2	-0.1	-0.9	0.2
High cholesterol (Self-reported)	0.5	0.8	3.0	0.1	0.7	0.4	-1.7	1.1	0.8	0.9	0.5	1.0
Medication: Atorvastatin	0.5	0.6	2.5	0.6	0.6	0.0	-1.0	1.6	0.3	1.0	0.6	0.4
Ever depressed for a whole week	0.5	0.7	2.5	0.6	-0.2	-0.1	-0.3	1.6	-0.0	1.3	0.1	-1.1
Leg fat mass (left)	0.5	2.1	6.0	2.4	0.9	0.6	-0.6	1.7	1.9	1.6	0.7	1.3
Depressed Affect (Nagel 2018)	0.4	0.9	2.2	1.1	1.5	-0.0	0.1	0.2	1.1	0.0	1.5	0.9
Depression (Nagel 2018)	0.4	0.7	2.9	1.7	0.5	-0.3	-0.9	-0.4	1.0	0.5	-0.4	0.7
Reaction Time	0.4	0.8	3.4	-1.2	-0.1	-0.1	-1.8	1.0	0.3	-0.6	-0.5	0.9
HbA1C	0.4	0.4	1.7	-0.8	0.7	-1.3	0.2	-0.4	-0.6	-0.1	0.3	-0.4
LDL Cholesterol	0.4	0.6	3.4	-0.3	-0.7	-0.8	-1.8	-0.7	-0.1	0.5	-0.5	0.2
Neuroticism (2016)	0.4	0.6	1.4	1.2	0.7	-0.7	-0.7	-0.4	1.2	0.8	0.3	0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	0.7	0.9	1.0	-0.7	1.1	0.3	0.2	0.5	0.5
Respiratory disease	0.4	0.8	3.7	-1.2	-0.6	1.0	-1.9	-0.1	-0.3	0.3	-0.9	0.1
Medication for hormone replacement therapy	0.4	0.4	1.5	0.9	0.3	1.2	-0.3	0.6	0.6	0.0	0.4	0.6
Diabetes (father)	0.4	0.5	1.1	0.5	0.6	1.1	0.9	0.2	0.6	-0.1	0.8	0.7
Townsend deprivation index at recruitment	0.4	0.5	1.8	0.8	0.6	0.4	-0.3	-0.3	1.3	0.8	-0.1	1.0
Maternal smoking around birth	0.4	0.6	2.0	0.7	0.7	0.1	-1.0	0.7	0.9	1.4	0.6	-0.0
Sitting height	0.4	2.6	5.4	0.8	-2.3	-1.3	1.8	-1.9	-1.2	0.4	-1.4	-2.3
Allergy	0.4	0.9	3.8	-1.9	-0.0	-1.2	0.4	0.1	-1.0	-1.4	-0.2	-0.3
Weight	0.4	1.9	5.4	2.3	0.3	0.2	-0.9	1.3	1.7	2.2	0.7	0.7
Impedance of arm (right)	0.4	1.9	5.8	-0.2	0.6	2.4	2.0	-0.5	-0.5	-2.4	0.3	0.5
Impedance of arm (left)	0.4	1.9	6.5	-0.6	0.4	2.4	1.9	-0.3	-0.8	-2.5	0.3	0.3
Hair/balding pattern: Pattern 4	0.4	1.1	3.0	-1.7	0.2	-1.0	0.4	1.0	-0.4	-1.7	0.9	0.8
Birth weight of first child	0.4	0.6	4.2	-0.4	-0.9	-0.5	-0.1	-2.1	-0.3	-0.3	-0.3	0.3
Loud music exposure frequency	0.4	0.5	1.3	-0.1	0.6	0.6	0.5	0.3	0.4	-1.1	0.8	1.1
Comparative body size at age 10	0.4	1.1	2.8	-1.7	-1.2	-0.9	-0.1	-0.0	-1.5	-0.2	-0.9	-1.2
Number of children fathered	0.4	0.5	2.2	-1.5	-0.2	-0.9	-0.7	-0.1	-0.8	-0.3	0.5	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	-1.1	0.9	-1.0	0.6	-0.6	-0.4	-0.3	0.5	0.2
Diabetes diagnosed by doctor	0.4	0.6	3.1	1.8	-0.2	0.1	0.1	0.4	0.5	1.2	-0.2	-0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.4	-0.1	0.1	-0.5	1.1	1.0	0.3	0.7	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.8	0.6	-0.5	0.0	-1.3	0.1	0.8	0.9	-0.2	0.5
Arm predicted mass (left)	0.4	1.9	7.6	1.6	-0.3	-1.3	-1.7	0.4	1.4	2.8	0.4	-0.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.4	1.3	0.5	0.6	1.5	0.8	0.1	1.3	1.1	-0.9
Worry (Nagel 2018)	0.3	0.6	1.5	-0.0	1.2	-0.3	-1.0	0.4	0.6	0.3	1.1	0.6
Primary Biliary Cirrhosis	0.3	0.5	1.4	-1.1	-0.0	-0.1	0.7	0.8	-0.4	-1.2	-0.0	0.4
Blood Red Count	0.3	2.7	9.6	3.1	0.9	1.5	0.2	-0.2	2.5	1.1	0.8	1.8
Systolic Blood Pressure	0.3	1.7	6.0	-1.1	2.5	0.8	0.5	0.5	0.5	-1.1	1.6	1.8
Chronotype (morning person)	0.3	0.6	2.8	0.9	0.1	-0.2	-1.1	-0.5	0.8	1.7	-0.1	-0.3
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.4	1.2	0.4	0.2	-0.9	0.3	1.0	0.5	0.0	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.3	1.5	-0.4	0.1	-0.2	-0.1	0.3	0.8	-0.5	-0.4
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.1	0.4	-0.3	-0.7	0.8	0.5	0.1	0.6	0.8
Angina	0.3	0.4	1.1	0.0	-1.1	0.7	-0.7	-0.5	-0.2	0.6	-0.7	-0.7
Average weekly fortified wine intake	0.3	0.4	0.7	-0.9	0.5	0.4	0.2	0.9	-0.8	-0.2	-0.1	-0.8
Relative age voice broke	0.3	0.5	0.9	0.4	0.8	0.6	0.3	0.4	0.4	-0.8	0.9	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.0	0.7	-0.8	-0.9	0.4	-0.7	-0.3	0.4	-0.8	-1.4
Serious illness, injury or assault to yourself	0.3	0.3	1.0	0.8	-0.5	-0.3	0.3	0.0	-0.5	0.1	-0.9	-1.0
Stomach or abdominal pain in last month	0.3	0.3	1.1	0.3	-0.2	0.8	-1.0	0.3	0.6	0.5	0.1	0.5
Alcohol intake versus 10 years previously	0.3	0.5	2.3	0.7	0.0	0.5	0.3	1.5	0.3	0.7	0.5	0.3
Pulse rate	0.3	0.4	1.6	0.1	1.1	1.3	-0.1	0.6	0.2	-0.1	0.5	0.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.8	1.3	-0.4	-0.3	1.0	-1.2	-0.1	0.3	-0.5	-0.6
Prospective memory result	0.3	0.4	1.7	0.2	0.2	-0.7	-1.3	-0.1	0.6	1.0	0.1	0.1
Standing height	0.3	2.6	6.4	0.0	-2.2	-1.8	-0.5	-2.5	-0.9	1.1	-1.3	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.1	-0.5	-0.3	0.9	0.5	0.8	-0.8	-1.1	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.4	0.6	0.3	-0.3	-0.8	0.7	0.7	0.6	1.2	0.6
Headache pain in last month	0.3	0.5	2.9	1.7	-0.3	0.3	-0.1	-0.6	0.7	0.7	-0.4	-0.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.7	0.2	-0.2	0.4	1.6	-0.3	-0.5	-1.0	-0.0	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.0	-1.0	-0.3	0.8	0.8	0.6	-0.7	-0.8	0.3	-0.7
Medication: Amlodipine	0.3	0.4	1.9	-0.5	0.1	1.4	0.5	0.2	-0.2	-0.7	-0.0	0.5
Arm fat-free mass (right)	0.3	1.5	6.1	1.0	-0.9	-1.4	-1.6	-0.1	0.7	2.5	-0.3	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.5	0.4	0.3	0.1	-0.7	-1.2	0.3	0.8	-0.2	-0.1
Medication: Blood pressure	0.3	0.5	1.6	-1.3	0.6	-0.3	-1.0	0.3	0.2	-0.3	0.1	1.1
Angina (self-reported)	0.3	0.4	1.0	0.1	-1.0	0.9	-0.5	-0.5	-0.2	0.5	-0.5	-0.7
Arm predicted mass (right)	0.3	1.7	5.7	1.1	-0.9	-1.8	-1.6	-0.4	0.8	2.4	-0.4	-0.6
Suffer from ‘nerves’	0.3	0.5	2.0	-0.6	0.0	-1.4	-0.7	0.4	-0.6	-0.3	-0.6	-0.7
Smoking status: Previous	0.3	0.4	1.4	-0.4	0.6	-0.4	0.1	1.1	0.2	0.2	1.2	0.3
Average weekly red wine intake	0.3	0.5	1.3	0.5	0.4	-1.0	0.7	-1.2	-0.4	0.5	0.3	-0.7
Medication: Lisinopril	0.3	0.4	1.3	-0.1	-0.3	0.8	1.1	-0.4	-0.6	0.1	-0.5	-0.7
Arm fat-free mass (left)	0.3	1.7	7.2	1.6	-0.5	-1.2	-1.5	0.2	1.2	2.7	0.0	-0.3
Average weekly beer plus cider intake	0.3	0.5	1.2	-0.6	-0.4	1.1	0.7	0.9	-0.5	-0.6	0.6	-0.1
Fractured/broken bones in last 5 years	0.3	0.3	1.0	0.5	-0.6	-0.0	0.5	-0.7	-0.4	-0.3	-1.0	-0.5
Crohns Disease (2017)	0.2	0.5	2.4	-0.3	0.8	0.3	-1.5	-0.3	0.7	0.1	0.2	0.4
Blood Platelet Count	0.2	2.7	7.7	-2.8	-1.0	-0.8	0.6	0.8	-2.7	-0.6	-0.9	-2.3
Height	0.2	4.6	14.0	0.9	-1.5	-2.9	-3.7	0.3	1.4	3.7	0.9	-0.6
Cardiovascular Disease	0.2	0.6	1.8	-0.3	1.3	0.7	0.3	0.8	0.3	-0.2	1.1	0.8
Neuroticism	0.2	0.6	2.6	0.5	0.8	-1.6	-0.8	-0.2	0.6	0.5	0.5	0.1
Relative age of first facial hair	0.2	0.5	1.2	-0.5	0.7	0.1	1.1	-0.4	-0.2	-1.1	0.9	0.4
Severe depression (siblings)	0.2	0.2	0.8	0.1	-0.4	0.2	-0.8	0.9	-0.2	-0.2	-0.6	-0.3
Leg fat-free mass (left)	0.2	0.8	3.5	1.2	0.1	-0.5	-0.9	0.3	1.1	1.9	0.6	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.8	-0.5	-0.1	0.2	-0.5	-0.0	0.5	-0.7	-0.5
High blood pressure	0.2	0.6	1.4	-1.1	1.0	1.2	0.1	0.0	-0.2	-0.7	0.9	0.8
Leg predicted mass (left)	0.2	0.8	3.4	1.2	0.1	-0.5	-0.9	0.4	1.0	1.9	0.6	0.0
Past tobacco smoking	0.2	0.3	1.5	-0.1	-0.0	0.9	0.1	-1.2	-0.2	-0.4	-0.7	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.3	0.6	0.1	0.2	-1.1	-0.2	0.4	0.2	-0.2	0.5
Trunk fat-free mass	0.2	1.3	4.5	0.5	-0.8	-1.9	-1.2	-0.5	0.4	2.1	-0.2	-0.9
Worrier / anxious feelings	0.2	0.3	1.3	-0.5	1.1	0.0	-0.2	-0.3	0.1	-0.4	0.4	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.4	-0.1	-0.2	-0.3	0.6	1.2	-0.3	0.0	0.1	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.4	1.7	0.3	-0.3	-1.3	0.5	0.4	-0.5	-0.7	-0.6	-0.4
Trunk predicted mass	0.2	1.3	4.7	0.6	-0.9	-1.8	-1.2	-0.6	0.4	2.2	-0.2	-0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.2	0.1	-0.1	-0.3	-0.7	1.1	0.5	-0.1	-0.1	0.6
Gout (self-reported)	0.2	0.3	0.8	-0.6	0.4	-0.5	-0.4	0.9	0.3	0.2	0.8	0.5
Migraine (self-reported)	0.2	0.3	0.7	0.5	-0.1	0.6	-0.8	0.0	0.5	0.4	-0.6	0.5
Comparative height size at age 10	0.2	1.2	3.2	0.4	-1.8	-0.5	-1.7	-1.0	0.8	1.6	-0.3	-0.2
Chest pain or discomfort	0.2	0.3	1.2	1.1	-0.2	0.9	0.4	0.1	0.2	0.7	0.3	-0.4
Hypertension (Self-reported)	0.2	0.6	1.6	-1.3	0.8	1.0	0.7	-0.4	-0.7	-1.0	0.5	0.4
Whole body fat-free mass	0.2	1.2	5.3	1.0	-0.5	-1.3	-1.2	-0.1	0.8	2.3	0.1	-0.6
Medication: Gliclazide	0.2	0.2	0.6	0.3	0.1	0.4	0.4	0.5	-0.1	0.8	0.3	-0.4
Whole body water mass	0.2	1.1	5.0	0.9	-0.5	-1.3	-1.2	-0.1	0.7	2.2	0.1	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.1	-0.1	-0.5	-0.7	0.5	0.5	0.2	0.1	0.5
Ever smoked	0.2	0.3	1.6	-0.4	-0.4	-1.3	0.4	0.9	-0.2	-0.2	0.2	-0.2
Basal metabolic rate	0.2	1.2	5.4	1.4	-0.3	-0.8	-1.2	0.3	1.1	2.3	0.3	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.8	0.9	0.6	0.1	0.6	0.2	0.1	0.2	0.8	-0.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.2	1.1	-0.9	-0.8	0.2	-0.5	0.2	0.2	-0.9	-0.5
Cholesterol lowering medication	0.2	0.3	2.0	0.0	0.1	0.3	-0.6	1.4	0.2	-0.1	0.2	0.5
Impedance of whole body	0.2	1.0	3.2	0.1	-0.3	1.6	1.4	-0.9	-0.6	-1.8	-0.5	0.0
Neuroticism (Nagel 2018)	0.1	0.3	0.8	0.1	0.9	-0.7	-0.0	-0.1	0.4	-0.2	0.8	0.4
Crohns Disease (2012)	0.1	0.2	1.1	0.5	0.1	0.5	-0.5	-1.1	0.4	-0.1	-0.3	0.1
Lupus	0.1	0.2	0.8	-0.1	0.4	0.6	0.1	0.6	0.3	0.1	0.9	0.2
Blood White Count	0.1	0.8	3.1	1.8	-0.2	0.7	1.7	0.6	0.2	0.2	-0.3	-0.4
Tanning	0.1	1.3	4.3	1.8	-0.0	1.5	1.2	-2.1	0.4	0.1	-0.5	-0.3
Impedance of leg (right)	0.1	0.7	1.3	0.6	-0.8	0.5	1.0	-1.1	-0.6	-0.9	-1.1	-0.6
Age when periods started (menarche)	0.1	0.2	0.5	-0.5	0.0	-0.7	-0.4	-0.5	0.3	-0.3	0.6	0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.1	-0.2	-0.1	0.5	-0.3	-0.2	0.2	0.3	-0.6
Impedance of leg (left)	0.1	0.5	0.9	0.5	-0.7	0.7	0.7	-0.9	-0.6	-0.8	-0.9	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.2	1.1	-0.0	-0.9	0.0	0.1	0.7	0.5	0.1	0.1
Medication: Simvastatin	0.1	0.1	0.3	0.1	-0.6	-0.1	-0.4	0.0	-0.0	0.5	-0.2	-0.3
Neuroticism score	0.1	0.3	1.1	0.1	1.0	-0.1	-0.1	0.8	0.4	-0.2	0.8	0.5
Hip circumference	0.1	0.6	1.8	1.4	0.7	0.3	0.8	0.9	0.7	0.1	0.4	0.9
Illnesses of siblings: Diabetes	0.1	0.1	0.5	0.3	0.4	-0.3	-0.2	-0.7	0.4	0.3	0.2	0.4
Leg fat-free mass (right)	0.1	0.8	3.5	1.0	0.0	-0.4	-1.0	0.3	0.9	1.9	0.6	-0.0
Leg predicted mass (right)	0.1	0.7	3.6	1.0	0.0	-0.3	-1.0	0.2	0.9	1.9	0.6	-0.1
Blood Eosinophil Count	0.0	0.4	1.0	-0.6	-1.0	0.7	-1.0	0.4	-0.1	0.5	0.2	-0.2
Heel T-Score	0.0	0.4	0.8	0.7	-0.4	0.9	0.9	-0.4	-0.1	-0.3	0.3	-0.7
Hair Pigment	0.0	0.5	1.5	1.2	0.5	0.4	-0.7	0.2	0.9	0.6	0.8	0.8

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