Hub : Genes

ASXL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.0920 0.0410 1.6e-03 0.031 NA 0.003 NA 0.020 1.5e-02 NA 2.3e-01 NA 4.3e-02
2 YFS Blood 0.0296 0.0116 3.5e-07 0.021 0.022 0.020 0.022 0.021 1.7e-07 6e-08 2.2e-07 6.5e-08 1.1e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.2 0.3 0.3 0.5
Bipolar Disorder or Schizophrenia 0.0 0.1 0.1 -0.3 0.3
Depressed Affect (Nagel 2018) 0.5 1.1 1.2 -1.1 1.0
Depression (Nagel 2018) 0.7 1.0 1.3 -1.1 0.8
Intelligence (Savage-Jansen 2018) 5.2 16.0 16.7 4.1 -3.9
Neuroticism (Nagel 2018) 0.0 0.1 0.2 0.2 -0.4
Schizophrenia (2018) 0.1 0.2 0.4 -0.7 0.0
Schizophrenia vs Biploar Disorder 0.2 0.3 0.3 -0.4 -0.6
Worry (Nagel 2018) 2.7 5.7 6.7 2.2 -2.6
Alzheimer’s Disease (in mother) 1.0 1.1 1.9 1.4 -0.6
Alzheimer’s Disease (in father) 0.6 0.6 1.1 -1.1 0.3
Alzheimer’s Disease (including proxy) 0.3 0.5 0.5 0.7 -0.7
Crohns Disease (2017) 3.8 8.4 9.4 -3.1 2.7
Irritable Bowel Disease (IBD) 7.6 18.1 18.4 -4.3 4.2
Ulcerative Colitis (UC) 6.6 12.3 13.7 -3.3 3.7
Major Depression (MDD) 1.1 1.4 1.4 -1.2 1.2
Reaction Time 0.8 1.6 1.8 1.2 -1.3
Verbal and Numeric Reasoning (VNR) 6.0 14.3 15.2 3.9 -3.7
Breast Cancer 3.0 7.3 9.1 2.4 -3.0
Ovarian Cancer 0.8 1.0 1.6 -1.3 0.7
Prostate Cancer 0.2 0.2 0.3 0.5 -0.4
Age at First Birth 8.3 12.0 13.3 3.3 -3.7
Bipolar Disorder (2011) 0.7 0.6 1.0 1.0 -0.6
Body Mass Index (BMI) (2010) 1.7 2.3 2.7 1.4 -1.7
Coronary Artery Disease (CAD) 0.3 0.4 0.6 -0.4 0.8
Crohns Disease (2012) 3.5 5.6 6.1 -2.5 2.3
Mean Putamen Volume 2.9 3.3 3.8 -1.7 1.9
Fasting Glucose 0.4 0.4 0.6 0.8 -0.5
HbA1C 1.0 1.1 1.2 -1.1 1.0
HDL Cholesterol 0.2 0.3 0.4 -0.7 0.4
LDL Cholesterol 0.1 0.2 0.2 0.4 -0.5
Lupus 1.2 1.8 3.0 1.7 -0.8
Neuroticism (2016) 1.1 1.6 2.1 -1.4 1.1
Primary Biliary Cirrhosis 2.2 3.2 3.4 -1.7 1.8
Rheumatoid Arthritis 0.7 0.9 1.2 1.1 -0.8
Schizophrenia (2014) 0.0 0.1 0.1 -0.2 -0.3
Triglycerides 0.0 0.0 0.0 0.0 0.1
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.1 0.6 -1.0
Ulcerative Colitis 5.5 8.0 9.2 -2.6 3.0
Blood Eosinophil Count 1.2 9.0 10.8 2.7 -3.3
Blood Platelet Count 0.8 9.1 11.7 3.4 -2.5
Blood Red Count 3.1 30.4 45.7 -3.9 6.8
Blood White Count 0.2 1.6 2.1 -1.5 1.0
Heel T-Score 0.5 3.8 6.0 1.3 -2.4
BMI 0.5 2.6 4.0 2.0 -1.1
Height 0.1 1.7 1.7 -1.3 1.3
Waist Hip Ratio (WHR) 1.7 7.9 10.2 -3.2 2.4
Systolic Blood Pressure 1.0 4.9 7.6 -1.5 2.8
Smoking Status 7.4 17.7 19.3 -4.0 4.4
Allergy or Eczema 0.0 0.1 0.1 0.2 -0.4
Cardiovascular Disease 0.8 2.8 4.1 -1.2 2.0
Hypothyroidism (self reported) 1.3 2.9 3.2 1.6 -1.8
Respiratory disease 0.2 0.4 0.5 0.7 -0.6
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.6 -0.8 0.5
Lung FEV1/FVC ratio 0.8 3.9 4.8 -1.7 2.2
Lung FVC 0.0 0.2 0.5 0.7 0.0
Neuroticism 0.1 0.2 0.3 0.5 -0.5
Chronotype (morning person) 5.7 13.1 13.2 3.6 -3.6
Hair Pigment 0.1 3.1 4.8 -1.2 2.2
Tanning 1.6 20.0 23.9 -4.9 4.0
Hand grip strength (left) 0.3 0.7 0.9 0.8 -0.9
Number of treatments/medications taken 3.1 5.6 5.7 -2.4 2.4
Average weekly spirits intake 1.4 1.7 1.8 -1.3 1.4
Sensitivity / hurt feelings 0.0 0.1 0.1 0.2 -0.3
Frequency of depressed mood in last 2 weeks 0.3 0.5 0.9 -0.9 0.2
Hearing difficulty/problems: Yes 3.8 5.8 6.5 -2.6 2.2
Relative age of first facial hair 0.3 0.7 0.9 0.6 -1.0
Other serious medical condition/disability diagnosed by doctor 8.8 11.4 14.1 -3.8 3.0
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 -0.5 0.3
Ever had hysterectomy (womb removed) 6.5 7.4 10.0 -3.2 2.2
Systolic blood pressure, automated reading 0.2 0.5 0.9 0.3 1.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.5 0.2
Angina 0.1 0.1 0.1 -0.4 -0.1
Medication for hormone replacement therapy 7.7 8.6 11.7 -3.4 2.4
Vitamin and mineral supplements 0.1 0.1 0.1 -0.3 -0.3
Supplements: Zinc 0.7 0.7 1.3 -0.4 1.2
Medication: Co-codamol 4.5 5.2 6.0 -2.5 2.1
Medication: Metformin 0.4 0.6 0.8 -0.9 0.6
Diabetes (father) 0.1 0.1 0.2 -0.5 -0.0
Diabetes (mother) 0.4 0.5 0.9 -0.2 0.9
Severe depression (siblings) 0.4 0.5 0.6 -0.8 0.6
Pack years adult smoking proportion 2.8 4.2 4.4 -2.0 2.1
Impedance of leg (right) 2.3 11.3 12.4 -3.5 3.2
Leg fat-free mass (left) 0.3 1.8 2.4 1.6 -1.1
Trunk fat percentage 0.1 0.4 0.7 0.8 -0.2
Hand grip strength (right) 0.1 0.2 0.4 0.6 -0.3
Townsend deprivation index at recruitment 6.6 9.3 10.9 -2.8 3.3
Current tobacco smoking 5.5 8.9 9.7 -2.9 3.1
Average weekly fortified wine intake 4.8 5.6 7.1 2.0 -2.7
Maternal smoking around birth 4.2 6.0 8.1 -2.0 2.8
Fed-up feelings 0.2 0.4 0.4 -0.6 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 3.0 -1.7 1.3
Relative age voice broke 0.3 0.4 0.5 -0.7 0.6
Taking other prescription medications 7.4 11.4 15.8 -4.0 2.7
Age when periods started (menarche) 2.4 5.8 6.9 2.1 -2.6
Bilateral oophorectomy (both ovaries removed) 3.3 3.8 4.8 -2.2 1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 0.8 0.9 -0.9
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 0.8 -0.4 0.9
Qualifications: CSEs or equivalent 13.1 17.2 18.7 -4.3 4.0
Serious illness, injury or assault to yourself 3.0 3.7 4.4 -1.7 2.1
High blood pressure 0.1 0.2 0.3 0.1 0.6
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.0 0.1 0.0
Multivitamins +/- minerals 0.3 0.4 0.7 0.8 0.0
Stomach or abdominal pain in last month 2.8 3.5 4.1 -1.7 2.0
Supplements: Glucosamine 2.1 2.7 4.0 -1.2 2.0
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 0.0 -0.4
Medication: Atenolol 0.1 0.2 0.3 0.5 -0.3
Medication: Levothyroxine sodium 2.2 3.7 5.0 1.6 -2.2
Sitting height 0.7 5.0 5.2 -2.3 2.2
Chronic bronchitis/emphysema (father) 1.1 1.3 2.4 -0.5 1.6
High blood pressure (mother) 0.3 0.5 0.5 -0.7 0.6
Body mass index (BMI) 0.7 2.9 4.4 2.1 -1.2
Impedance of leg (left) 4.2 20.4 22.6 -4.8 4.3
Leg predicted mass (left) 0.3 1.7 2.4 1.6 -1.0
Trunk fat mass 0.1 0.4 0.8 0.9 -0.3
Waist circumference 0.0 0.1 0.2 0.5 0.1
Number of incorrect matches in round 5.7 9.4 10.3 -3.2 2.9
Past tobacco smoking 4.2 7.7 9.7 2.4 -3.1
Alcohol usually taken with meals 1.9 3.1 4.3 1.4 -2.1
Nervous feelings 0.6 1.1 1.6 0.8 -1.3
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.8 2.7 -1.6 1.0
Hearing difficulty/problems with background noise 0.0 0.1 0.1 -0.3 0.3
Hair/balding pattern: Pattern 2 0.2 0.2 0.4 -0.1 -0.6
Had menopause 0.6 0.8 1.4 1.2 -0.5
Had other major operations 0.0 0.0 0.1 -0.0 -0.3
Forced vital capacity (FVC) 0.9 3.4 4.2 -1.6 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.5 0.7 -0.5
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 2.5 -0.9 1.6
Qualifications: None of the above 0.1 0.1 0.2 0.2 0.4
Financial difficulties in last 2 years 10.5 14.1 15.7 -4.0 3.5
Mouth/teeth dental problems 4.6 7.1 9.6 3.1 -2.1
Heart attack 1.2 1.6 2.2 -1.5 1.0
Allergy 0.0 0.0 0.0 0.0 -0.1
Pain all over the body in last month 0.2 0.2 0.3 0.5 -0.2
Diabetes (self-reported) 0.2 0.3 0.6 -0.8 -0.0
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.0 0.1 -0.1
Medication: Ramipril 0.3 0.4 0.7 -0.8 0.2
Medication: Simvastatin 0.7 1.0 1.0 -1.0 1.0
Fluid intelligence score 3.4 7.1 7.6 2.8 -2.6
Illnesses of siblings 0.1 0.2 0.3 0.6 0.2
Neuroticism score 0.0 0.1 0.2 -0.4 0.2
Weight 0.3 1.3 2.3 1.5 -0.6
Impedance of arm (right) 0.4 1.9 1.9 -1.4 1.4
Arm fat percentage (right) 0.7 2.8 4.3 2.1 -1.1
Trunk fat-free mass 0.1 0.4 0.7 0.8 -0.2
Hip circumference 0.4 1.8 3.1 1.8 -0.7
Time employed in main current job 2.4 2.7 2.7 1.6 -1.7
Alcohol intake versus 10 years previously 1.3 2.0 3.2 1.8 -0.8
Father’s age at death 6.5 8.8 9.6 3.1 -2.8
Worrier / anxious feelings 3.0 5.6 5.8 2.3 -2.4
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 2.3 -1.3 1.5
Falls in the last year 2.8 3.8 3.9 -2.0 1.9
Hair/balding pattern: Pattern 3 4.1 6.1 7.6 2.1 -2.8
Number of live births 0.3 0.4 0.9 -0.1 0.9
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 4.2 -1.5 2.1
Pulse rate 0.0 0.0 0.1 -0.2 0.1
Happiness 1.7 2.1 2.2 -1.4 1.5
Noisy workplace 0.7 0.9 1.1 -0.8 1.0
Qualifications: A levels/AS levels or equivalent 2.4 5.4 6.5 2.0 -2.6
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 0.8 -0.7 0.9
Mouth/teeth dental problems: Dentures 3.3 5.5 6.0 -2.5 2.2
Asthma 0.2 0.5 0.5 0.7 -0.7
Medication: Ibuprofen (e.g. Nurofen) 6.6 8.4 9.3 -2.7 3.1
Medication: Cholesterol lowering 0.7 1.1 1.2 -1.1 1.0
Depression (self-reported) 2.3 2.7 3.8 -1.9 1.3
Medication: Lansoprazole 0.4 0.4 0.5 -0.7 0.6
Prospective memory result 2.2 2.8 3.7 1.3 -1.9
Lung cancer (father) 0.0 0.0 0.1 0.1 0.3
Illnesses of mother 0.0 0.0 0.0 -0.2 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 3.8 -1.7 2.0
Pulse wave Arterial Stiffness index 2.1 2.5 2.5 1.6 -1.6
Impedance of arm (left) 0.5 2.2 2.6 -1.4 1.6
Arm fat mass (right) 0.5 1.9 3.2 1.8 -0.8
Trunk predicted mass 0.1 0.4 0.7 0.8 -0.2
Standing height 0.1 0.9 1.0 -0.9 1.0
Length of working week for main job 4.7 5.2 5.2 -2.3 2.3
Exposure to tobacco smoke at home 1.6 1.8 2.2 -1.2 1.5
Breastfed as a baby 0.5 0.7 0.8 0.9 -0.7
Tense / ‘highly strung’ 0.0 0.1 0.2 -0.1 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.3 -1.1 1.0
Hair/balding pattern: Pattern 4 4.4 10.7 13.4 -2.8 3.7
Birth weight of first child 0.4 0.8 1.4 -0.4 1.2
Peak expiratory flow (PEF) 0.0 0.1 0.2 0.5 0.1
Pulse wave reflection index 0.2 0.2 0.4 -0.2 0.6
Ever highly irritable/argumentative for 2 days 0.5 0.6 0.9 -0.9 0.6
Loud music exposure frequency 1.9 2.1 2.6 -1.6 1.2
Qualifications: O levels/GCSEs or equivalent 3.1 5.0 6.5 2.5 -1.9
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.3 0.1 -0.6
Blood clot in the leg (DVT) 1.9 2.4 3.2 -1.3 1.8
Medication: Paracetamol 4.8 7.9 9.7 -2.5 3.1
Headache pain in last month 10.4 17.9 20.2 -3.9 4.5
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 1.4 1.2 -0.9
Glaucoma (self-reported) 0.1 0.1 0.1 -0.3 -0.3
Gout (self-reported) 1.8 2.5 2.9 -1.7 1.5
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 4.3 1.5 -2.1
Medication: Amlodipine 0.3 0.4 0.4 0.7 -0.6
Medication: Ventolin 100micrograms inhaler 1.5 2.0 2.6 1.2 -1.6
Birth weight 0.2 0.4 0.8 0.9 -0.3
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 -0.4 0.1
High blood pressure (siblings) 0.6 0.8 1.6 0.1 -1.3
Forced vital capacity (FVC), Best measure 0.6 2.0 2.0 -1.4 1.4
Body fat percentage 0.1 0.3 0.5 0.7 -0.1
Leg fat percentage (right) 0.1 0.2 0.4 0.6 -0.1
Arm fat-free mass (right) 0.0 0.2 0.5 0.7 0.0
Exposure to tobacco smoke outside home 0.1 0.1 0.3 -0.1 0.5
Comparative body size at age 10 3.7 10.3 11.9 3.5 -3.0
Number of full brothers 1.5 1.9 2.6 -1.1 1.6
Worry too long after embarrassment 0.0 0.1 0.1 -0.2 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.3 3.8 -1.7 1.9
Wheeze or whistling in the chest in last year 0.4 0.8 1.1 -0.7 1.1
Number of children fathered 0.2 0.2 0.3 -0.5 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.6 1.3 -0.3
Age at first live birth 4.4 7.9 8.9 2.6 -3.0
Pulse wave peak to peak time 2.4 2.8 3.0 -1.7 1.6
Health satisfaction 0.0 0.0 0.1 -0.2 0.2
Shortness of breath walking on level ground 0.1 0.1 0.1 0.3 0.2
Qualifications: College or University degree 0.9 2.8 4.6 1.0 -2.2
Eye problems/disorders: None of the above 1.8 2.1 2.9 -1.2 1.7
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 -0.1 0.1
Emphysema/chronic bronchitis 0.3 0.3 0.5 0.4 -0.7
Medication for pain relief, constipation, heartburn 7.1 12.2 14.6 3.1 -3.8
Neck or shoulder pain in last month 6.5 9.3 9.7 -3.0 3.1
Medication: Blood pressure 0.5 0.9 1.1 -1.0 0.9
Angina (self-reported) 0.1 0.1 0.2 -0.3 -0.4
Migraine (self-reported) 4.8 6.0 6.4 -2.5 2.4
Medication: Ibuprofen 5.4 6.4 6.7 -2.5 2.6
Medication: Allopurinol 2.9 3.9 4.0 -1.9 2.0
Medication: Omeprazole 0.5 0.6 1.2 -1.1 0.1
Medication: Seretide 50 evohaler 0.2 0.2 0.4 0.6 -0.2
Mean time to correctly identify matches 1.3 2.4 2.7 1.5 -1.6
Heart disease (mother) 0.9 1.1 1.7 0.7 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 2.6 1.6 -0.9
Whole body fat mass 0.1 0.4 0.7 0.8 -0.2
Leg fat mass (right) 0.1 0.4 0.7 0.8 -0.3
Arm predicted mass (right) 0.0 0.1 0.1 0.4 0.2
Pulse rate, automated reading 0.1 0.4 0.5 -0.6 0.7
Alcohol intake frequency. 0.0 0.1 0.1 0.2 0.3
Comparative height size at age 10 0.7 3.7 3.8 -1.9 1.9
Number of full sisters 0.1 0.1 0.1 -0.2 -0.2
Suffer from ‘nerves’ 1.2 1.9 2.5 1.1 -1.6
Overall health rating 2.5 5.3 5.5 -2.3 2.3
Chest pain or discomfort 1.6 2.3 3.4 1.1 -1.9
Had major operations 0.3 0.3 0.6 -0.8 0.3
Age at last live birth 2.0 2.8 3.2 1.6 -1.8
Family relationship satisfaction 0.3 0.3 0.6 -0.2 0.8
Leg pain on walking 2.4 2.9 3.2 -1.8 1.6
Qualifications: NVQ or HND or HNC or equivalent 10.0 12.0 12.9 -3.6 3.3
Commuting to job workplace: Car/motor vehicle 0.8 1.0 1.7 -1.3 0.5
Illness, injury, bereavement, stress in last 2 years 3.7 4.5 5.3 1.9 -2.3
Medication: Aspirin 0.8 1.1 1.3 -1.1 0.9
Supplements: Vitamin C 0.6 0.7 1.3 -0.0 1.2
Knee pain experienced in last month 3.4 5.3 5.8 -2.2 2.4
Hypertension (Self-reported) 0.0 0.1 0.1 0.3 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 1.6 -0.5 -1.3
Illnesses of father: Heart disease 0.8 1.2 1.2 1.1 -1.1
Illnesses of siblings: Diabetes 1.2 1.5 1.9 -1.1 1.4
Smoking status: Previous 2.1 3.1 3.8 -1.5 1.9
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 3.2 -1.4 1.8
Whole body fat-free mass 0.1 0.5 0.9 0.9 -0.3
Leg fat-free mass (right) 0.2 0.8 1.2 1.1 -0.7
Arm fat percentage (left) 0.7 2.8 4.5 2.1 -1.1
Average weekly red wine intake 0.9 1.3 1.5 1.2 -1.0
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 0.1 -0.1
Mood swings 0.5 1.0 1.2 -0.9 1.1
Loneliness, isolation 0.1 0.2 0.2 -0.3 0.5
Long-standing illness, disability or infirmity 6.4 9.7 11.0 -3.3 2.9
Ever had bowel cancer screening 0.2 0.2 0.4 -0.7 0.1
Diabetes diagnosed by doctor 0.2 0.4 0.7 -0.9 0.1
Ever had stillbirth, spontaneous miscarriage or termination 3.4 3.7 5.8 -1.3 2.4
Friendships satisfaction 0.3 0.4 0.5 -0.5 0.7
Qualifications: nursing, teaching 0.5 0.7 0.9 -1.0 0.7
Commuting to job workplace: Walk 0.2 0.2 0.4 0.6 -0.3
Eye problems/disorders: Cataract 4.5 5.2 5.5 2.3 -2.2
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 4.6 -2.2 0.9
Medication for cholesterol 0.2 0.3 0.3 0.6 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 0.9 -0.9 1.0
Back pain experienced in last month 2.8 4.1 4.6 -1.9 2.1
Mineral and other dietary supplements 1.5 2.0 3.6 0.6 -1.9
Breast cancer (self-reported) 0.7 0.8 1.1 -0.6 1.1
Asthma (self-reported) 0.3 0.6 0.6 0.8 -0.8
Osteoporosis (self-reported) 0.4 0.5 0.6 0.8 -0.7
Osteoarthritis (self-reported) 0.3 0.4 0.7 -0.8 0.4
Medication: Aspirin 0.3 0.4 0.5 -0.7 0.4
Medication: Gliclazide 0.1 0.1 0.1 -0.4 0.2
Illnesses of father: None of the above (group 1) 0.4 0.5 0.7 -0.8 0.5
Smoking status: Current 4.9 7.7 8.5 -2.6 2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.6 0.8 -0.6
Whole body water mass 0.1 0.6 1.1 1.0 -0.4
Leg predicted mass (right) 0.2 0.9 1.3 1.1 -0.7
Arm fat mass (left) 0.5 1.9 3.2 1.8 -0.8
Number of self-reported non-cancer illnesses 1.2 2.1 2.3 -1.5 1.4
Average weekly champagne plus white wine intake 0.3 0.4 0.7 -0.2 -0.8
Miserableness 1.2 2.0 2.1 -1.4 1.5
Guilty feelings 1.4 2.2 2.8 -1.2 1.7
Wears glasses or contact lenses 0.2 0.2 0.2 -0.4 -0.5
Ever taken oral contraceptive pill 1.4 1.6 2.6 -1.6 0.8
Hearing aid user 0.7 0.7 0.8 -0.9 0.8
Mother’s age at death 1.9 2.4 3.3 1.8 -1.2
Financial situation satisfaction 6.0 7.4 9.2 -2.4 3.0
Tinnitus: Yes, now most or all of the time 3.6 4.2 4.8 2.2 -1.9
Commuting to job workplace: Public transport 0.5 0.6 1.1 1.0 -0.2
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 0.5 -0.3
Medication: Blood pressure 0.1 0.3 0.4 0.7 -0.3
Pain type(s) experienced in last month: Hip pain 3.1 3.9 4.9 -2.2 1.7
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.0 0.5 1.0
High cholesterol (Self-reported) 2.7 4.9 5.0 -2.2 2.2
Medication: Bendroflumethiazide 0.4 0.6 0.7 -0.7 0.9
Medication: Paracetamol 4.5 6.9 8.4 -2.3 2.9
Medication: Lisinopril 0.2 0.3 0.5 -0.7 0.2
Medication: Atorvastatin 2.0 2.5 2.6 -1.5 1.6
Illnesses of father: High blood pressure 2.1 2.6 4.3 -0.9 2.1
Alcohol drinker status: Never 0.4 0.5 0.6 0.8 -0.7
Ever smoked 2.3 4.1 5.4 -1.7 2.3
Basal metabolic rate 0.1 0.6 1.1 1.0 -0.4
Leg fat percentage (left) 0.0 0.1 0.2 0.0 0.4
Arm fat-free mass (left) 0.1 0.5 0.9 1.0 -0.3
Number of operations (self-reported) 0.5 0.7 0.9 -0.9 0.7
Average weekly beer plus cider intake 0.2 0.2 0.3 0.6 -0.3
Irritability 0.0 0.1 0.1 0.2 -0.3
Risk taking 0.7 1.1 1.4 -0.9 1.2
Ever had prostate specific antigen (PSA) test 4.3 4.9 6.0 2.0 -2.4
Fractured/broken bones in last 5 years 1.3 1.7 2.1 -1.1 1.5
Age started oral contraceptive pill 4.1 5.1 5.2 2.2 -2.3
Diastolic blood pressure, automated reading 0.9 2.7 4.2 -1.1 2.1
Ever depressed for a whole week 3.5 4.3 4.7 -2.0 2.2
Unable to work because of sickness or disability 5.3 6.8 7.9 -2.8 2.4
Commuting to job workplace: Cycle 1.4 1.7 2.3 1.5 -1.0
Myopia 0.5 0.7 1.1 -1.0 0.6
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.1 0.3 -1.1
Cholesterol lowering medication 0.0 0.1 0.1 -0.1 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 -0.1 -0.5
Pain experienced in last month 16.2 27.1 30.2 4.9 -5.5
Supplements: Calcium 1.2 1.3 1.4 -1.2 1.1
Basal cell carcinoma (self-reported) 0.1 0.1 0.1 0.3 -0.2
Heart attack/myocardial infarction (self-reported) 1.2 1.5 2.1 -1.5 1.0
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 3.1 -1.2 1.8
Heart disease (siblings) 0.5 0.6 1.1 0.4 -1.0
Alcohol drinker status: Previous 3.4 3.9 5.3 -1.6 2.3
Pack years of smoking 1.6 2.4 2.6 -1.5 1.6
Impedance of whole body 1.9 9.8 10.7 -3.3 3.0
Leg fat mass (left) 0.0 0.1 0.2 0.4 0.1
Arm predicted mass (left) 0.1 0.3 0.6 0.7 0.1