Hub : Genes

ATF6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0610	0.0220	1.1e-03	0.013	0.010	0.015	0.017	0.014	8.8e-03	1.7e-02	5.5e-03	3.3e-03	7.3e-03
2	GTEx	Artery Aorta	0.1480	0.0490	5.1e-04	0.084	NA	0.082	NA	0.089	2.3e-05	NA	2.7e-05	NA	1.3e-05
3	GTEx	Cells Transformed fibroblasts	0.1590	0.0540	3.0e-04	0.087	NA	0.054	NA	0.066	4.4e-07	NA	7.1e-05	NA	1.0e-05
4	GTEx	Nerve Tibial	0.1166	0.0449	1.1e-03	0.074	NA	0.030	NA	0.044	6.3e-06	NA	3.2e-03	NA	4.6e-04
5	GTEx	Testis	0.2340	0.0840	5.0e-03	0.076	NA	0.031	NA	0.049	3.0e-04	NA	1.6e-02	NA	3.3e-03
6	GTEx	Thyroid	0.1670	0.0410	3.2e-07	0.109	NA	0.144	NA	0.145	1.0e-08	NA	3.9e-11	NA	3.4e-11
7	NTR	Blood	0.0809	0.0163	8.9e-16	0.055	0.057	0.068	0.059	0.063	2.9e-17	7.1e-18	4.5e-21	2.1e-18	1.5e-19
8	YFS	Blood	0.1168	0.0198	0.0e+00	0.084	0.107	0.117	0.122	0.118	3.4e-26	4.8e-33	3.1e-36	1.0e-37	2.1e-36
9	TCGA	Breast Invasive Carcinoma	0.0267	0.0109	5.6e-05	0.014	0.019	0.001	NA	0.012	6.7e-04	6.3e-05	1.7e-01	NA	1.1e-03
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0577	0.0273	9.0e-04	0.004	0.025	0.012	NA	0.011	1.1e-01	7.7e-04	1.6e-02	NA	1.7e-02
11	TCGA	Ovarian Serous Cystadenocarcinoma	0.0540	0.0260	3.7e-03	0.002	0.021	-0.001	NA	0.005	2.2e-01	1.4e-02	3.5e-01	NA	1.3e-01
12	TCGA	Prostate Adenocarcinoma	0.0621	0.0276	7.4e-04	0.021	0.040	0.022	NA	0.022	2.6e-03	4.9e-05	2.1e-03	NA	1.9e-03
13	TCGA	Thyroid Carcinoma	0.0910	0.0330	6.3e-07	0.082	0.064	0.061	NA	0.064	2.1e-08	7.8e-07	1.3e-06	NA	8.3e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.6	1.0	2.7	-0.5	-1.3	-0.4	-1.6	-0.0	-1.2	-0.4	0.9	-1.1	-1.2	-0.7	-0.8	-1.1
Bipolar Disorder or Schizophrenia	0.5	1.1	4.1	-1.3	-0.3	-0.8	-2.0	1.7	-1.1	0.1	1.1	-1.1	-0.8	-0.4	0.0	-0.9
Depressed Affect (Nagel 2018)	0.3	0.6	1.7	-0.5	0.6	0.7	0.7	0.9	0.7	-0.1	0.2	0.3	0.9	0.6	1.2	1.3
Depression (Nagel 2018)	0.8	1.2	4.3	-0.5	0.9	0.4	1.7	1.6	1.0	0.2	0.0	0.4	1.4	0.5	2.1	1.3
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.7	-0.3	-1.3	-0.7	-0.2	-1.6	-1.0	-0.6	-0.6	0.2	0.1	-0.9	-2.2	-0.7
Neuroticism (Nagel 2018)	0.2	0.4	3.0	-1.3	0.2	-0.2	-0.3	1.7	-0.2	-0.3	-0.1	-0.1	0.1	0.1	0.3	0.5
Schizophrenia (2018)	0.4	0.8	4.7	-1.3	0.7	-0.8	-1.3	2.2	-0.5	0.5	0.6	-0.4	-0.1	0.1	0.7	-0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	1.4	0.4	0.5	-1.2	-0.6	0.3	-0.5	-1.0	-0.8	0.3	0.6	0.3	0.3	0.0
Worry (Nagel 2018)	0.3	0.7	3.6	-1.7	-0.2	-0.4	-0.3	1.9	-0.5	-0.2	0.1	-0.6	-0.7	-0.7	-0.2	-0.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	0.8	0.3	0.2	0.6	0.4	0.5	0.7	0.0	0.4	-0.3	0.6	0.7	0.2
Alzheimer’s Disease (in father)	0.8	0.8	5.4	-0.8	0.8	0.3	-1.7	0.5	-0.2	0.6	2.3	-0.4	0.4	-0.1	-0.2	-0.1
Alzheimer’s Disease (including proxy)	0.3	0.4	2.3	-0.2	0.4	0.3	-0.7	1.1	0.1	0.9	1.5	-0.0	-0.2	0.6	0.6	-0.1
Crohns Disease (2017)	1.0	2.2	15.8	-1.5	-0.5	-0.5	-2.6	-4.0	-0.8	-0.4	1.0	-0.9	-0.9	-0.6	-0.2	-0.4
Irritable Bowel Disease (IBD)	1.8	4.3	52.6	-0.5	-1.0	-0.0	-1.1	-7.2	-0.4	-0.7	0.1	0.1	-0.4	-0.2	0.2	0.1
Ulcerative Colitis (UC)	2.2	4.1	45.7	1.4	-0.5	0.5	1.0	-6.8	0.5	-0.5	-0.6	1.3	0.5	0.4	0.5	0.8
Major Depression (MDD)	2.0	2.4	7.0	-0.6	-1.2	-2.4	-0.5	-0.2	-1.9	-2.1	-2.6	-1.1	-0.3	-1.5	-1.6	-1.6
Reaction Time	0.3	0.5	2.7	0.6	0.4	0.1	-0.2	1.6	0.3	1.1	0.6	-0.2	0.5	0.5	1.0	0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	6.4	-0.0	-1.5	-0.8	0.0	-1.9	-1.1	-0.7	-0.9	0.3	-0.2	-0.6	-2.5	-1.2
Breast Cancer	0.2	0.4	2.0	-0.6	-0.9	0.2	1.1	-1.4	-0.1	-0.4	-0.8	0.2	-0.0	-0.1	-0.6	0.0
Ovarian Cancer	0.5	0.7	4.4	0.2	-0.2	-0.7	-2.1	-1.3	-0.9	0.1	0.2	-0.2	0.1	-0.3	-0.9	-0.2
Prostate Cancer	0.7	1.0	2.5	-0.5	1.0	1.6	1.4	-0.4	1.4	0.6	0.8	1.1	-0.4	0.8	0.9	1.1
Age at First Birth	0.4	0.6	3.3	1.8	-0.6	-0.3	-0.2	-0.8	-0.6	-0.8	-0.9	0.2	-0.1	0.1	-1.2	-0.5
Bipolar Disorder (2011)	1.4	1.4	3.8	-0.8	-1.2	-1.1	-1.9	0.3	-1.5	-0.8	0.1	-1.3	-1.6	-1.2	-0.6	-1.2
Body Mass Index (BMI) (2010)	0.3	0.4	4.2	2.0	-0.4	0.3	0.5	-0.5	0.2	0.3	-0.5	0.0	-0.5	0.2	-0.4	0.2
Coronary Artery Disease (CAD)	1.2	1.5	3.1	-0.6	-1.4	-1.5	-0.4	-0.9	-1.3	-1.7	-1.8	-0.7	-1.6	-1.4	-0.8	-0.9
Crohns Disease (2012)	0.9	1.5	9.1	-1.8	-0.9	0.5	-1.4	-3.0	-0.2	0.0	1.2	-0.8	-1.1	-0.6	0.2	-0.3
Mean Putamen Volume	0.8	0.9	3.1	0.9	1.0	0.6	0.2	-1.3	0.9	0.6	0.1	0.5	1.8	1.0	1.2	0.8
Fasting Glucose	0.7	0.9	2.6	0.6	1.1	0.8	0.1	-0.5	0.8	0.5	1.1	1.2	0.2	1.6	1.3	1.1
HbA1C	1.1	1.2	2.7	-0.5	1.1	1.1	-0.2	-0.2	0.9	1.3	1.7	1.3	0.9	1.3	1.1	1.4
HDL Cholesterol	0.1	0.1	0.3	-0.6	-0.4	0.6	0.4	0.0	0.1	-0.5	-0.1	0.1	-0.3	-0.3	0.0	-0.2
LDL Cholesterol	0.5	0.8	1.5	-0.7	0.6	1.1	1.2	-0.5	1.2	1.0	0.8	1.1	0.7	0.3	0.8	0.7
Lupus	1.3	2.0	19.1	0.0	0.7	-1.3	-1.2	4.4	-0.7	0.2	0.6	-1.3	-0.6	0.2	0.9	-0.0
Neuroticism (2016)	0.7	1.1	2.3	-0.6	0.3	-1.5	-1.3	-0.5	-1.3	-1.2	-0.6	-1.4	-0.2	-1.2	-1.2	-0.9
Primary Biliary Cirrhosis	1.0	1.4	3.1	-0.2	1.3	1.0	1.3	1.1	1.4	0.7	-0.2	1.2	1.8	0.8	1.5	1.5
Rheumatoid Arthritis	0.6	0.9	2.0	1.0	1.4	0.4	0.9	-0.8	0.8	1.2	-0.0	1.4	1.1	0.8	0.3	0.9
Schizophrenia (2014)	0.5	1.1	8.1	-1.1	-0.2	-0.5	-1.2	2.9	-0.7	0.3	0.6	-0.8	-1.0	-0.4	0.0	-0.7
Triglycerides	0.1	0.1	0.5	0.5	0.1	0.3	0.4	-0.6	0.3	0.7	0.4	0.2	0.0	-0.2	-0.2	0.2
Type 2 Diabetes (T2D) (2012)	2.7	3.1	5.5	1.6	1.4	1.6	2.2	1.8	1.9	0.7	0.5	2.1	2.1	2.1	1.4	2.4
Ulcerative Colitis	1.4	2.0	23.2	0.4	-0.5	0.8	0.8	-4.8	0.2	-0.1	0.2	0.7	-0.3	0.2	0.2	0.3
Blood Eosinophil Count	0.1	0.9	3.6	1.0	0.6	1.2	0.1	-1.9	0.8	-0.1	1.3	0.9	0.5	0.8	0.0	0.9
Blood Platelet Count	0.3	3.2	16.1	-0.6	1.6	0.9	-3.5	0.1	0.5	0.4	4.0	0.1	0.4	0.9	2.6	1.3
Blood Red Count	0.2	2.3	8.0	-0.5	0.7	1.4	2.8	-1.2	1.4	1.1	-0.9	2.1	2.6	0.4	-0.4	1.4
Blood White Count	0.6	4.5	31.6	1.4	-1.0	0.7	-3.3	-5.6	-0.5	-0.5	1.8	0.5	-2.2	0.2	-2.1	-0.3
Heel T-Score	0.2	1.4	14.3	-3.8	-0.4	0.1	0.5	0.2	-0.1	0.4	0.1	-0.7	-1.6	-0.4	-0.2	-0.6
BMI	0.2	1.4	4.0	1.9	-0.1	1.6	-0.7	1.6	0.9	1.1	2.0	0.6	0.7	1.0	-0.1	0.8
Height	0.0	0.9	2.5	1.2	0.9	0.3	1.6	1.3	0.8	-0.2	-0.5	1.1	-0.1	1.4	-0.4	0.7
Waist Hip Ratio (WHR)	0.2	0.8	2.6	1.6	1.5	0.1	-0.6	0.1	0.5	1.0	0.6	0.6	0.6	0.7	0.8	1.0
Systolic Blood Pressure	0.2	1.0	2.4	-0.5	-0.9	-0.8	-1.0	-0.2	-1.2	-0.3	-0.4	-1.6	-1.2	-1.4	-1.1	-1.1
Smoking Status	0.4	0.9	2.8	1.2	-1.0	-0.7	0.3	-1.3	-0.5	-1.7	-1.5	-0.6	-0.5	-0.8	0.2	0.1
Allergy or Eczema	0.2	0.4	3.4	-1.1	0.1	-0.3	-0.0	1.8	-0.3	0.2	0.4	-0.0	0.5	0.2	-0.3	-0.1
Cardiovascular Disease	0.1	0.3	1.7	0.2	0.2	0.5	-0.6	0.2	0.0	0.7	1.3	-0.5	-0.3	-0.2	0.3	-0.4
Hypothyroidism (self reported)	0.7	1.5	5.9	-0.8	1.0	0.7	-1.1	2.4	0.4	1.1	2.3	0.7	0.6	0.9	1.2	0.9
Respiratory disease	0.1	0.3	3.1	0.2	-0.0	-0.1	-0.2	1.8	0.0	0.3	-0.2	0.1	0.6	0.0	0.5	0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	2.0	0.3	-0.1	0.3	0.1	0.6	0.4	0.6	0.1	0.3	1.4	0.6	0.4	1.0
Lung FEV1/FVC ratio	1.0	5.1	16.1	-0.9	-2.1	-1.4	-4.0	-2.6	-2.6	-2.0	0.4	-2.4	-1.8	-2.3	-2.2	-2.4
Lung FVC	0.8	4.2	11.3	0.1	-1.7	-2.1	1.5	0.6	-1.5	-2.6	-3.2	-1.1	-3.4	-1.8	-1.9	-2.4
Neuroticism	0.3	0.7	5.6	-1.5	-0.1	-0.1	-0.5	2.4	-0.4	-0.4	0.4	-0.6	-0.7	-0.4	0.3	-0.1
Chronotype (morning person)	0.2	0.5	2.4	-1.5	0.0	0.7	0.9	-1.0	0.4	0.9	0.3	0.3	0.7	-0.2	0.4	0.3
Hair Pigment	0.0	1.1	4.9	0.6	-0.4	-1.1	-0.3	-1.2	-0.9	-2.2	-2.0	0.1	0.4	-0.8	-0.2	-0.2
Tanning	0.1	0.7	2.6	1.6	0.9	0.7	0.7	0.2	1.0	1.4	0.2	0.7	-0.5	1.0	-0.6	0.5
Hand grip strength (left)	0.2	0.6	6.3	-0.7	-0.0	0.6	-0.3	2.5	0.4	0.4	0.5	0.1	0.4	0.5	-0.3	0.3
Number of treatments/medications taken	0.4	0.8	5.1	-0.0	0.9	-1.1	-0.9	-0.2	-0.1	0.5	-0.1	-0.2	0.9	0.2	2.3	0.9
Average weekly spirits intake	0.6	0.7	2.3	1.5	0.9	0.7	0.8	0.1	0.9	0.8	0.6	0.8	1.0	0.7	-0.0	1.2
Sensitivity / hurt feelings	0.1	0.1	0.7	-0.8	-0.1	0.2	0.4	0.2	-0.1	-0.5	-0.0	0.5	-0.3	0.2	-0.3	0.2
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.9	-0.9	1.0	0.8	1.5	1.7	1.1	0.8	0.4	0.4	0.5	0.7	1.3	1.2
Hearing difficulty/problems: Yes	1.0	1.6	4.4	-0.9	-2.1	-0.9	0.1	0.2	-1.0	-1.7	-1.6	-1.2	-1.2	-1.6	-1.2	-1.1
Relative age of first facial hair	0.8	1.6	4.2	-1.5	0.7	2.0	1.2	-0.6	1.6	1.1	1.6	0.7	0.9	0.9	1.5	1.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.7	-0.4	0.7	0.8	0.3	-1.6	0.8	0.6	1.2	0.6	0.9	0.7	1.2	0.9
Ever used hormone-replacement therapy (HRT)	0.9	1.2	3.3	-0.9	-0.6	-1.8	-0.9	-0.7	-1.5	-1.5	-0.9	-1.2	-0.6	-1.4	0.3	-0.8
Ever had hysterectomy (womb removed)	0.2	0.3	0.8	-0.5	0.9	0.3	0.2	0.1	0.3	0.9	0.8	-0.6	-0.2	-0.0	0.7	0.2
Systolic blood pressure, automated reading	0.6	1.8	4.2	-0.9	-1.5	-1.7	-2.1	-0.3	-1.8	-0.7	-0.6	-1.9	-0.4	-2.0	-0.9	-0.9
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.9	-0.5	0.9	1.7	0.7	-0.7	1.4	0.8	1.3	1.0	0.4	1.3	1.7	1.2
Angina	0.7	0.9	2.8	-1.7	-0.3	-1.4	-1.1	-0.3	-1.0	-0.6	-0.9	-1.2	-0.7	-0.8	0.6	-0.7
Medication for hormone replacement therapy	0.4	0.5	1.6	0.6	1.0	-1.3	0.7	0.4	-0.2	-0.3	-1.0	0.2	0.6	-0.1	0.7	0.7
Vitamin and mineral supplements	0.2	0.2	0.6	0.4	0.6	0.1	0.8	-0.5	0.3	0.2	-0.2	0.3	0.8	0.3	0.1	0.7
Supplements: Zinc	2.3	2.5	6.1	-0.1	1.6	0.9	1.1	1.5	1.6	0.6	0.7	2.0	2.5	2.3	2.0	1.8
Medication: Co-codamol	0.5	0.6	3.2	-0.5	0.6	-1.2	-1.8	-0.1	-0.9	-0.4	0.4	-0.1	0.8	0.4	-0.5	0.5
Medication: Metformin	0.2	0.3	1.2	-0.7	-0.5	-0.5	-1.1	0.3	-0.7	-0.2	0.2	-1.0	-0.0	-0.4	0.2	-0.1
Diabetes (father)	0.9	1.1	4.5	-0.2	-0.6	-1.9	-0.0	-0.6	-1.1	-1.6	-2.1	-0.8	0.2	-1.1	-0.1	-0.5
Diabetes (mother)	0.6	0.7	1.8	-0.3	-1.3	-0.4	-0.2	-0.4	-0.8	-0.8	-0.6	-1.2	-0.8	-1.3	-0.6	-1.2
Severe depression (siblings)	0.7	0.8	4.4	-0.8	0.6	0.5	-1.6	-0.1	-0.1	1.3	2.1	0.1	-0.6	0.1	0.1	-0.2
Pack years adult smoking proportion	1.3	2.0	3.7	-0.2	-1.3	-1.8	-1.9	1.6	-1.7	-1.8	-1.0	-1.5	-1.5	-1.3	0.4	-1.0
Impedance of leg (right)	0.3	1.3	5.0	-0.3	-0.3	-2.1	-0.4	-1.1	-1.2	-0.6	-2.2	-0.8	-1.0	-1.1	-0.0	-1.2
Leg fat-free mass (left)	0.2	1.1	5.0	1.2	0.2	1.3	0.5	2.2	0.9	0.6	1.2	0.6	0.6	1.1	-0.5	0.8
Trunk fat percentage	0.1	0.4	1.5	0.6	-0.0	0.7	-0.4	1.0	0.3	0.9	1.2	0.1	0.3	0.7	0.5	0.4
Hand grip strength (right)	0.2	0.4	4.5	0.6	-0.1	0.2	-0.2	2.1	-0.0	-0.1	0.1	-0.1	-0.7	0.1	-0.3	-0.5
Townsend deprivation index at recruitment	3.6	5.1	9.8	0.2	2.3	1.9	3.0	1.3	2.7	1.5	-0.0	2.3	2.7	2.4	3.0	3.1
Current tobacco smoking	0.6	1.0	3.6	1.1	-0.6	-1.3	0.3	-1.4	-0.5	-1.8	-1.9	-0.4	-0.7	-0.5	0.2	-0.2
Average weekly fortified wine intake	1.3	1.5	3.7	-0.4	-0.8	-1.9	-1.5	0.4	-1.5	-0.4	-0.7	-1.4	-1.1	-1.8	-1.1	-1.3
Maternal smoking around birth	0.9	1.2	4.2	0.1	0.8	1.0	0.2	0.7	1.1	0.7	1.1	1.5	0.8	1.0	2.0	1.6
Fed-up feelings	0.3	0.6	1.6	-0.3	0.4	0.9	1.3	1.1	0.9	0.4	0.2	0.2	0.3	0.8	0.9	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.7	-1.1	0.2	-0.7	0.2	0.8	-0.2	-1.3	-0.7	-0.5	-0.0	-0.5	0.9	0.0
Relative age voice broke	0.9	1.3	3.4	-1.1	0.7	1.4	1.2	-0.4	1.2	0.6	1.3	1.1	0.9	1.2	1.8	1.2
Taking other prescription medications	0.3	0.5	1.9	-1.0	-0.1	-1.4	-0.7	-0.7	-0.7	-0.4	-0.4	-0.4	-0.2	-0.7	1.1	0.1
Age when periods started (menarche)	0.4	1.0	2.5	-0.2	1.6	0.9	-0.2	0.1	1.1	0.7	1.3	1.1	0.8	1.6	1.1	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.5	-0.6	-0.1	-0.0	0.8	1.0	-0.0	-0.4	-0.1	-0.0	0.4	-0.0	1.2	0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	7.9	0.5	1.8	2.1	2.8	-0.4	2.4	1.5	0.7	2.5	1.3	2.2	2.0	2.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.1	0.7	0.1	1.1	-0.1	0.7	0.4	0.6	1.5	0.2	-0.0	0.4	0.4	0.1
Qualifications: CSEs or equivalent	0.6	0.8	3.5	0.1	0.2	0.5	0.8	1.9	0.7	1.0	-0.1	0.5	0.8	0.4	1.6	0.8
Serious illness, injury or assault to yourself	0.8	1.0	3.1	-1.6	-0.1	1.2	0.3	-1.7	0.6	0.8	1.1	-0.2	0.0	0.0	1.8	0.3
High blood pressure	0.5	1.4	3.2	1.6	1.6	0.5	0.4	1.4	1.1	1.1	0.4	0.2	1.8	0.7	1.7	1.0
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.6	-1.9	-0.2	0.3	-0.8	1.3	-0.2	0.5	1.6	-0.3	-0.2	0.3	-0.5	-0.4
Multivitamins +/- minerals	0.4	0.5	2.0	0.8	0.3	0.8	0.3	0.8	0.6	1.4	0.6	0.7	-0.4	1.0	-0.4	-0.0
Stomach or abdominal pain in last month	0.4	0.5	3.2	-1.8	-0.3	0.1	-0.2	-0.1	-0.1	-0.8	0.0	-0.7	-0.2	-0.9	0.8	-0.2
Supplements: Glucosamine	1.0	1.3	3.0	0.5	-0.8	-1.7	-1.0	-0.9	-1.2	-0.5	-1.0	-1.4	-1.7	-1.1	0.2	-1.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.7	0.1	0.0	-0.4	0.6	0.7	0.3	-0.2	-1.2	0.8	1.3	0.5	0.6	0.4
Medication: Atenolol	0.5	0.7	2.4	1.5	0.5	-0.9	0.9	1.2	0.1	0.4	-1.3	0.1	0.7	0.2	0.4	0.5
Medication: Levothyroxine sodium	0.3	0.4	1.8	0.4	0.2	0.4	0.5	0.8	0.4	-0.1	0.5	0.6	0.6	0.8	1.4	1.0
Sitting height	0.0	0.3	0.8	0.9	0.5	0.2	0.2	0.8	0.2	0.5	0.7	0.5	-0.3	0.8	-0.9	0.1
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	1.0	0.2	0.5	-0.8	0.1	0.3	-0.3	0.9	0.3	0.2	1.0	0.7	0.4
High blood pressure (mother)	0.9	1.2	3.5	-1.1	-0.3	-0.0	-1.9	1.1	-0.8	0.3	1.2	-1.6	-1.1	-0.8	-1.3	-1.3
Body mass index (BMI)	0.3	1.2	3.8	0.8	0.2	1.4	-0.2	1.9	0.8	0.9	1.8	0.6	1.2	1.0	0.6	1.1
Impedance of leg (left)	0.2	1.2	3.9	-0.3	0.0	-2.0	-0.3	-1.5	-1.1	-0.5	-1.8	-0.7	-1.2	-0.9	0.2	-1.2
Leg predicted mass (left)	0.2	1.2	5.2	1.3	0.2	1.4	0.5	2.3	0.9	0.6	1.3	0.7	0.6	1.2	-0.5	0.9
Trunk fat mass	0.2	0.7	3.4	1.1	0.0	0.8	-0.2	1.8	0.5	0.9	1.2	0.4	0.4	0.9	0.3	0.7
Waist circumference	0.2	0.8	3.1	1.2	0.5	0.7	-0.5	1.8	0.5	0.8	1.1	0.3	0.8	0.8	0.6	1.0
Number of incorrect matches in round	0.3	0.6	1.7	0.4	-0.1	-1.1	-0.1	-1.3	-0.6	-0.7	-0.4	-0.7	-0.7	-1.2	-0.2	-0.9
Past tobacco smoking	0.1	0.3	0.9	-0.9	0.3	0.3	0.5	1.0	0.3	0.8	-0.1	0.4	0.1	0.1	-0.4	-0.2
Alcohol usually taken with meals	0.2	0.4	1.3	0.1	-0.5	-0.6	-1.1	-0.1	-0.9	0.2	0.4	0.1	-0.3	-0.3	-1.2	-0.6
Nervous feelings	0.3	0.6	1.5	-1.2	-0.8	-1.0	-0.5	0.9	-0.9	-0.8	-1.2	-0.3	0.1	-0.5	-0.8	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	5.0	-1.2	1.5	-0.1	1.3	2.0	0.9	-0.3	-0.4	0.6	1.1	1.0	2.2	1.4
Hearing difficulty/problems with background noise	0.3	0.4	0.9	-0.6	-0.4	-0.6	0.5	0.8	-0.3	-0.8	-0.6	-0.9	-0.9	-0.9	0.5	-0.3
Hair/balding pattern: Pattern 2	0.2	0.3	1.7	1.3	-0.6	-0.4	-0.1	0.5	-0.2	-0.8	-0.7	-0.1	0.4	-0.4	-0.2	0.1
Had menopause	0.3	0.4	1.8	1.3	0.5	-0.6	0.6	-1.4	-0.0	-0.2	-0.8	0.2	0.4	-0.4	0.4	0.1
Had other major operations	0.5	0.7	2.8	-0.2	-0.3	-1.2	-1.7	-0.4	-1.1	-0.9	-0.4	-0.8	-0.3	-0.3	0.5	-0.9
Forced vital capacity (FVC)	0.4	1.7	6.1	1.0	-0.9	-1.0	1.6	2.0	-0.5	-1.4	-2.5	0.4	-1.3	0.0	-1.6	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	8.0	0.6	1.6	2.0	2.8	-0.5	2.2	1.5	0.9	2.3	0.9	2.1	1.7	2.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.5	0.1	-0.1	0.4	0.5	0.4	0.3	-0.0	0.3	0.7	-0.1	0.7	0.5	0.4
Qualifications: None of the above	0.5	1.0	3.3	1.5	1.4	0.2	0.2	0.7	0.7	0.7	0.2	1.0	1.3	1.0	0.9	1.8
Financial difficulties in last 2 years	0.5	0.7	2.7	-1.6	-0.6	0.2	-1.0	1.6	-0.3	-0.3	0.7	-0.5	-0.8	-0.3	1.0	-0.1
Mouth/teeth dental problems	1.3	2.0	5.6	1.5	0.1	2.2	2.4	1.9	1.6	0.9	0.2	1.8	0.2	1.5	-0.5	0.4
Heart attack	1.3	1.7	4.4	-0.1	-0.7	-2.1	-1.0	-1.5	-1.6	-1.1	-1.6	-1.5	-1.5	-1.1	-0.1	-1.4
Allergy	0.2	0.5	2.2	1.0	-0.3	-0.5	0.4	-1.2	-0.3	-0.7	-1.5	-0.5	-0.4	-0.7	-0.3	-0.3
Pain all over the body in last month	0.3	0.3	1.2	-0.6	0.4	0.2	-0.7	0.9	0.1	0.8	1.1	-0.1	-0.4	0.1	0.4	0.1
Diabetes (self-reported)	0.1	0.2	0.7	-0.1	0.2	0.3	0.6	0.1	0.5	0.2	-0.1	0.2	0.7	0.4	0.9	0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.7	-1.6	-0.1	0.9	-1.3	-0.4	0.1	0.8	1.6	0.0	-0.4	0.1	-0.6	-0.1
Medication: Ramipril	0.5	0.7	2.6	0.6	-0.4	-1.4	-1.6	-0.0	-1.1	-0.1	-0.7	-1.2	0.1	-0.9	-0.0	-0.1
Medication: Simvastatin	3.4	4.9	12.1	0.8	3.0	2.0	-1.0	-2.3	2.0	3.0	3.5	1.3	1.7	2.5	2.1	2.1
Fluid intelligence score	0.6	1.3	7.1	-0.1	-1.4	-0.6	0.0	-1.9	-1.0	-0.2	-0.7	0.2	-0.8	-0.7	-2.7	-1.3
Illnesses of siblings	0.3	0.4	1.9	-1.1	-0.3	0.8	0.7	-1.4	0.4	0.2	0.2	-0.0	-0.2	-0.4	-0.2	0.3
Neuroticism score	0.2	0.5	3.4	-1.4	-0.3	-0.0	-0.3	1.8	-0.1	-0.6	0.2	-0.3	-0.7	-0.3	0.4	0.0
Weight	0.3	1.3	5.9	1.6	0.4	1.1	0.2	2.4	0.8	0.8	1.2	0.8	1.0	1.3	0.0	1.0
Impedance of arm (right)	0.2	0.8	4.1	0.6	0.2	-1.7	-0.4	-2.0	-0.8	-0.1	-1.2	-0.4	-0.4	-0.2	-0.4	-0.7
Arm fat percentage (right)	0.2	0.7	2.7	0.8	0.3	0.7	-0.7	1.2	0.4	0.9	1.6	0.3	1.0	0.8	0.6	0.8
Trunk fat-free mass	0.2	1.1	8.7	1.5	-0.0	0.4	0.9	3.0	0.4	-0.3	-0.1	0.7	0.3	0.7	-0.8	0.5
Hip circumference	0.1	0.6	4.1	0.8	-1.0	-0.0	-0.1	2.0	-0.4	-0.6	-0.2	-0.2	0.2	0.1	-0.8	-0.2
Time employed in main current job	0.8	0.9	4.0	2.0	1.3	0.3	0.5	0.4	0.7	0.7	0.5	1.2	0.8	1.3	-0.5	0.4
Alcohol intake versus 10 years previously	0.5	0.8	4.3	-2.1	-0.6	-0.1	-0.8	-0.1	-0.7	-0.4	0.5	-1.4	-0.4	-1.0	-0.1	-1.0
Father’s age at death	0.2	0.3	1.4	0.3	-0.5	-0.1	-0.1	0.6	-0.3	-0.6	-0.4	0.2	-0.7	-0.4	-1.2	-0.6
Worrier / anxious feelings	1.7	3.3	5.4	-1.8	-1.1	-2.2	-1.6	2.1	-2.1	-1.8	-1.2	-1.8	-2.0	-1.8	-1.3	-2.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	7.8	-0.4	-0.5	-1.3	0.3	2.8	-0.6	-0.9	-1.4	-0.9	-0.5	-0.4	0.5	-0.1
Falls in the last year	1.0	1.3	4.7	-2.1	0.2	0.2	-1.3	0.1	-0.3	-0.5	2.2	-0.4	-1.0	-0.3	2.2	-0.3
Hair/balding pattern: Pattern 3	1.0	1.5	3.3	-1.5	-0.9	-1.1	-1.2	-1.8	-1.4	-0.9	-0.4	-1.4	-0.6	-1.2	-1.4	-1.1
Number of live births	0.2	0.3	1.7	1.3	0.1	-0.2	0.7	0.3	0.1	-0.7	-0.7	0.5	0.3	0.6	-0.3	0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.8	1.2	-1.2	-0.8	1.1	1.2	-0.7	-1.4	-2.2	0.1	-1.2	-0.2	-2.1	-1.2
Pulse rate	0.9	1.6	5.4	2.1	0.7	1.2	0.5	-0.5	1.2	1.2	0.4	1.5	2.3	1.0	-0.3	1.3
Happiness	0.4	0.5	1.4	0.6	-0.8	-0.5	0.4	-0.5	-0.3	-1.2	-0.9	-0.5	-1.1	-0.4	-0.8	-0.8
Noisy workplace	1.0	1.2	3.7	1.2	1.5	0.1	1.0	0.5	1.1	0.5	0.1	0.9	1.9	0.8	1.7	1.1
Qualifications: A levels/AS levels or equivalent	1.0	2.3	8.9	0.7	-2.0	-1.1	-0.5	1.4	-1.5	-1.3	-1.2	-0.9	-1.5	-1.1	-3.0	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	-0.1	-0.4	-1.1	-0.8	0.0	-1.0	0.2	-0.8	-1.4	-1.0	-0.9	-0.9	-1.1
Mouth/teeth dental problems: Dentures	0.7	1.2	5.7	-1.3	0.1	-1.0	-1.7	-2.4	-0.7	-0.5	0.5	-0.8	1.1	-0.6	0.7	0.5
Asthma	0.1	0.1	0.7	0.3	-0.6	-0.2	-0.4	0.8	-0.2	-0.1	-0.0	0.2	0.2	-0.1	0.3	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	3.9	2.0	0.0	-0.4	-0.2	1.5	-0.2	0.0	0.3	0.5	-0.3	0.1	-0.0	-0.2
Medication: Cholesterol lowering	0.7	1.0	4.8	-1.3	1.0	-0.7	-1.2	-1.7	-0.1	0.1	0.5	-0.6	0.2	0.3	2.2	0.5
Depression (self-reported)	0.4	0.5	1.6	-1.0	1.3	-0.2	0.1	0.0	0.5	-0.1	0.0	0.8	1.1	0.6	1.0	0.5
Medication: Lansoprazole	0.7	0.7	2.2	0.0	-0.3	-0.9	0.8	1.4	-0.4	-1.3	-1.5	-0.9	0.4	-1.1	-0.1	0.1
Prospective memory result	0.5	0.6	2.2	1.3	0.4	0.2	0.3	-0.5	0.4	0.9	-0.6	0.3	1.5	0.3	-1.2	0.3
Lung cancer (father)	0.4	0.5	1.6	0.7	-0.6	-0.9	-0.9	0.0	-0.8	-1.2	-0.7	-0.4	0.4	-0.8	-0.7	-0.2
Illnesses of mother	0.5	0.6	1.6	0.5	0.5	0.8	0.9	-0.6	0.8	0.8	0.1	1.2	0.9	1.0	0.4	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.7	1.5	-0.5	-0.7	1.6	1.4	-0.4	-1.3	-2.2	0.3	-0.8	-0.1	-1.9	-0.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	0.2	0.4	-0.4	0.4	0.8	-0.1	0.1	-0.2	-0.6	0.2	-0.6	0.4	0.3
Impedance of arm (left)	0.2	0.9	4.7	-0.2	-0.1	-1.5	-0.8	-2.2	-1.0	-0.1	-0.8	-0.6	-0.7	-0.3	-0.7	-0.9
Arm fat mass (right)	0.2	0.9	3.8	1.2	0.2	0.7	-0.4	1.9	0.5	0.7	1.3	0.4	1.0	0.9	0.3	0.8
Trunk predicted mass	0.2	1.1	8.7	1.6	-0.2	0.3	0.9	3.0	0.3	-0.4	-0.3	0.6	0.3	0.5	-0.9	0.4
Standing height	0.1	0.7	2.2	1.5	0.2	-0.9	0.6	1.4	-0.2	-0.4	-1.1	0.2	-0.6	0.5	-1.3	-0.3
Length of working week for main job	0.4	0.4	2.3	1.5	-0.0	0.0	-0.3	1.3	0.0	-0.4	-0.3	0.6	0.3	0.5	0.2	0.3
Exposure to tobacco smoke at home	1.3	1.5	5.0	-0.1	2.2	0.6	0.8	0.1	1.1	0.6	0.9	0.9	1.7	1.1	2.1	1.2
Breastfed as a baby	0.7	0.9	2.1	-0.4	1.0	1.0	1.3	0.0	1.0	0.9	0.1	0.6	1.0	0.8	1.4	1.2
Tense / ‘highly strung’	1.3	2.1	4.8	-2.2	-0.4	-2.0	-1.6	1.0	-1.6	-1.0	-0.8	-1.7	-2.0	-1.6	-0.1	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.8	-1.4	-0.7	-1.5	0.4	0.4	-0.8	-1.1	-2.2	-0.2	-1.0	-0.7	-0.3	-0.8
Hair/balding pattern: Pattern 4	0.1	0.3	2.1	-1.4	-0.8	-0.2	0.3	0.2	-0.3	-0.2	-0.8	-0.5	-0.3	-0.5	0.1	-0.6
Birth weight of first child	0.5	0.9	2.6	0.6	-1.1	-1.0	-0.9	-0.3	-1.0	-1.6	-1.1	-0.4	-0.7	-0.5	-1.1	-1.1
Peak expiratory flow (PEF)	0.3	0.6	2.1	1.4	-0.7	0.2	0.8	0.5	0.1	-0.6	-1.4	0.7	0.1	0.6	-1.0	-0.2
Pulse wave reflection index	1.0	1.2	3.3	-1.0	-0.7	-1.4	-0.5	1.1	-1.4	-1.2	-0.4	-1.8	-1.3	-1.1	-0.3	-1.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.4	-0.6	-0.1	0.1	-0.6	0.4	0.0	-0.3	0.7	-0.1	-0.2	-0.2	0.5	-0.1
Loud music exposure frequency	0.9	1.0	3.1	-1.8	-0.1	0.0	-0.6	0.8	-0.2	-0.5	1.5	-0.9	-1.5	-0.7	1.6	-0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	-0.9	-0.4	-1.1	-0.5	0.9	-0.8	-0.7	-0.8	-0.4	-0.5	-0.5	-1.2	-0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	4.0	-2.0	-0.3	-0.5	-0.9	-1.3	-0.6	-0.5	0.2	-1.5	-1.2	-1.2	0.9	-0.7
Blood clot in the leg (DVT)	0.9	1.2	2.2	0.4	0.9	1.4	1.2	0.7	1.0	1.5	1.3	1.4	1.1	1.3	0.0	1.0
Medication: Paracetamol	1.8	3.0	9.2	-1.3	1.8	2.0	0.2	2.4	1.5	1.5	3.0	0.8	0.4	1.2	2.6	1.2
Headache pain in last month	0.3	0.5	4.2	-0.3	-0.3	-0.0	-0.9	2.0	-0.4	-0.9	0.5	-0.3	0.1	0.0	-0.4	-0.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	3.3	0.4	-1.0	0.6	0.2	0.9	-0.1	-0.2	0.4	0.8	-0.4	-0.1	-1.8	-0.4
Glaucoma (self-reported)	0.8	0.9	4.1	-2.0	-1.0	-0.5	-1.1	-0.3	-0.9	-0.8	0.2	-1.4	-1.1	-0.7	0.2	-0.5
Gout (self-reported)	0.5	0.6	3.2	-0.4	-0.3	-0.8	-1.8	0.2	-0.9	-0.0	0.6	-0.9	-0.6	-0.7	-0.4	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.3	-1.1	-0.1	-0.3	-1.1	1.1	-0.5	0.0	1.1	-0.0	-0.2	0.1	0.9	0.1
Medication: Amlodipine	0.3	0.4	0.9	-1.0	0.0	-0.8	-0.1	0.4	-0.4	-0.4	-0.7	-0.7	-0.2	-0.8	0.8	-0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	4.9	-0.5	0.2	-0.9	-2.2	-0.0	-0.9	-0.4	0.7	0.2	1.1	0.1	-0.1	0.3
Birth weight	0.5	1.0	2.7	0.0	-0.7	-1.6	-1.0	0.3	-1.3	-1.6	-1.1	-0.8	-1.3	-0.3	-0.1	-0.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.0	-0.2	0.6	0.8	1.6	1.7	1.1	0.1	-0.0	0.7	0.9	0.5	1.0	0.8
High blood pressure (siblings)	0.4	0.6	2.7	-0.1	0.5	0.1	-1.6	1.6	-0.3	0.3	1.4	0.1	0.2	0.5	0.6	-0.2
Forced vital capacity (FVC), Best measure	0.4	1.4	4.4	1.5	-0.0	-0.7	2.0	2.0	0.0	-0.9	-2.1	0.6	-0.7	0.4	-1.3	-0.4
Body fat percentage	0.1	0.6	2.1	0.6	-0.0	0.8	-0.6	1.4	0.3	1.0	1.4	0.1	0.4	0.6	0.6	0.5
Leg fat percentage (right)	0.2	0.6	3.1	0.8	0.2	0.4	-0.6	1.8	0.3	0.8	0.8	0.2	0.8	0.5	0.7	0.8
Arm fat-free mass (right)	0.2	0.9	8.0	0.9	-0.1	1.0	0.6	2.8	0.5	0.2	0.7	0.5	0.0	0.6	-0.6	0.4
Exposure to tobacco smoke outside home	0.6	0.8	3.1	0.8	-0.3	1.1	1.8	0.9	0.9	0.3	-0.3	1.0	0.9	0.9	0.7	0.9
Comparative body size at age 10	0.3	0.8	2.7	1.1	-0.6	1.6	0.9	1.1	0.8	0.5	0.4	0.6	-0.2	0.8	-1.1	0.3
Number of full brothers	0.9	1.2	4.3	-2.1	-0.0	-1.0	-1.8	0.5	-1.0	-1.2	0.1	-1.0	-1.3	-0.5	-0.4	-0.9
Worry too long after embarrassment	0.7	1.2	7.0	0.6	-0.3	-1.5	-0.7	2.6	-1.0	-1.0	-1.5	-0.5	-0.1	-0.4	-0.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	6.6	-2.6	0.4	-1.2	-0.9	-0.0	-0.8	-0.1	-0.2	-1.3	-0.6	-1.5	0.5	-0.8
Wheeze or whistling in the chest in last year	0.3	0.6	1.8	0.8	-0.5	-0.8	-1.3	0.4	-0.6	-1.2	0.0	-0.5	1.0	-0.1	0.5	0.6
Number of children fathered	0.8	0.9	3.9	-1.0	0.1	1.6	-0.5	-0.7	0.5	0.7	2.0	0.3	0.1	1.0	-0.7	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.9	0.2	0.4	-0.2	0.7	0.9	0.1	0.3	0.1	-0.4	0.1	-0.5	-0.2	-0.3
Age at first live birth	1.2	2.1	7.1	2.5	-1.4	-0.8	0.9	0.1	-0.8	-0.9	-1.8	-0.5	-1.7	-0.8	-2.7	-1.5
Pulse wave peak to peak time	0.2	0.2	0.6	-0.2	-0.6	0.1	-0.5	-0.8	-0.2	-0.4	-0.2	0.4	-0.6	0.3	-0.8	-0.7
Health satisfaction	0.4	0.5	2.3	0.5	0.5	-0.0	0.9	-0.9	0.5	-0.2	0.1	0.6	0.8	0.8	1.5	0.4
Shortness of breath walking on level ground	0.3	0.3	1.6	0.6	0.1	0.4	0.5	1.0	0.4	-0.2	0.1	0.1	0.3	0.2	1.3	0.6
Qualifications: College or University degree	0.4	1.2	4.3	1.8	-0.8	-0.1	0.7	-1.0	-0.3	-0.1	-0.9	0.2	-1.5	-0.6	-2.1	-1.4
Eye problems/disorders: None of the above	0.4	0.5	3.1	0.5	-0.4	0.1	-0.5	0.1	-0.5	0.2	0.7	-0.3	-0.8	-0.4	-1.8	-1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.1	-0.4	-1.0	-0.2	-0.9	-0.4	-0.4	-0.3	0.2	-0.6	0.0	-0.5	-0.9	-0.0
Emphysema/chronic bronchitis	2.1	2.3	6.0	-0.2	1.8	1.4	1.1	-0.2	1.8	0.4	0.5	1.4	2.1	1.9	2.1	2.4
Medication for pain relief, constipation, heartburn	0.8	1.4	8.9	0.3	-1.6	0.0	1.0	-1.4	-0.3	-0.5	-1.8	-0.3	-0.2	-0.4	-3.0	-0.4
Neck or shoulder pain in last month	0.5	0.7	4.0	-1.3	0.6	0.8	-0.1	2.0	0.5	0.4	1.4	0.1	0.3	0.2	-0.1	0.3
Medication: Blood pressure	0.3	0.5	2.8	0.8	0.2	-1.2	-0.0	-0.7	-0.3	-0.1	-1.7	-0.8	0.4	-0.1	0.5	-0.1
Angina (self-reported)	0.7	0.9	2.6	-1.4	-0.2	-1.6	-1.1	-0.2	-1.0	-0.7	-1.0	-1.2	-0.5	-0.8	0.5	-0.6
Migraine (self-reported)	2.5	3.2	6.1	-2.0	-1.7	-2.2	-1.4	0.6	-2.1	-2.1	-0.8	-2.1	-2.5	-1.9	-0.1	-1.9
Medication: Ibuprofen	0.7	0.8	4.8	2.2	0.8	0.0	0.1	1.5	0.3	0.7	0.6	1.1	0.4	0.8	0.4	0.3
Medication: Allopurinol	0.1	0.2	0.7	-0.8	0.3	-0.2	-0.4	-0.2	0.0	-0.0	0.1	-0.4	0.2	-0.6	0.7	-0.1
Medication: Omeprazole	0.4	0.4	2.6	-0.5	0.3	-0.7	0.2	-0.1	-0.1	-0.0	-0.7	-0.5	0.9	-0.7	1.6	0.3
Medication: Seretide 50 evohaler	0.4	0.4	1.4	-0.3	-1.0	-0.1	-1.2	0.2	-0.8	0.0	1.0	-0.5	-0.5	-0.2	-0.4	-0.9
Mean time to correctly identify matches	0.1	0.2	0.8	0.3	0.3	-0.4	-0.4	0.9	-0.0	0.6	0.1	-0.5	0.7	0.2	0.8	0.2
Heart disease (mother)	0.6	0.8	2.2	-1.2	-1.5	-0.3	-0.2	-0.8	-0.6	-1.1	-0.3	-0.9	-0.8	-1.1	-0.6	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	4.6	2.1	0.1	0.8	1.2	-0.9	1.1	0.7	-1.0	1.6	1.6	1.7	0.5	1.5
Whole body fat mass	0.2	0.9	5.1	1.1	0.2	0.9	-0.3	2.3	0.5	0.9	1.4	0.3	0.5	0.8	0.5	0.7
Leg fat mass (right)	0.2	1.0	4.6	1.3	0.3	0.8	-0.3	2.1	0.6	0.9	1.1	0.4	0.9	0.8	0.6	0.9
Arm predicted mass (right)	0.2	1.1	8.9	0.9	-0.2	1.1	0.8	3.0	0.6	0.3	0.7	0.5	0.1	0.6	-0.7	0.4
Pulse rate, automated reading	0.2	0.6	2.2	1.5	-0.1	0.9	0.6	0.3	0.7	-0.4	0.3	0.5	1.3	0.5	0.1	0.9
Alcohol intake frequency.	1.3	3.0	6.3	-0.8	1.4	2.5	1.0	1.1	2.0	1.8	2.0	1.6	1.5	2.2	1.7	1.9
Comparative height size at age 10	0.1	0.6	3.2	1.8	0.7	0.2	1.2	0.6	0.6	0.3	-0.3	0.9	0.4	0.9	-0.2	0.2
Number of full sisters	0.3	0.4	2.2	-1.1	-0.1	-0.1	-0.5	-1.5	-0.2	0.2	0.3	-0.7	-0.5	-0.3	0.7	0.0
Suffer from ‘nerves’	0.7	1.0	8.8	-3.0	0.7	0.3	-0.6	1.0	0.2	0.7	1.3	-0.1	0.0	0.0	0.8	0.0
Overall health rating	0.2	0.5	2.7	-0.5	0.6	-0.3	-0.7	0.6	-0.1	0.3	1.1	-0.9	0.3	-0.1	1.6	0.5
Chest pain or discomfort	1.2	1.7	4.1	-2.0	-0.5	-1.6	-0.8	1.8	-1.2	-1.0	-0.4	-1.9	-0.9	-1.6	0.7	-1.0
Had major operations	0.6	0.7	4.8	-0.2	-0.8	-0.7	-2.2	-1.1	-0.9	-0.5	0.4	-0.6	0.0	-0.1	-0.7	0.1
Age at last live birth	1.4	2.0	9.4	3.1	-1.4	-0.9	1.0	-0.2	-0.7	-1.4	-2.4	-0.1	-0.5	-0.1	-2.1	-0.7
Family relationship satisfaction	1.3	1.6	3.9	-1.7	-1.7	-0.5	0.5	-0.4	-0.8	-1.5	-1.4	-1.1	-2.0	-1.5	-0.1	-1.3
Leg pain on walking	0.5	0.6	2.7	-0.9	0.1	-0.0	-0.8	1.6	-0.2	-0.1	1.1	-0.6	-0.1	-0.2	1.1	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.1	0.4	0.1	0.5	0.6	-0.1	0.5	0.5	0.4	0.4	0.3	0.4	1.0	0.3
Commuting to job workplace: Car/motor vehicle	1.6	1.8	4.3	1.4	-2.0	-1.0	-0.2	0.1	-1.2	-1.2	-1.4	-0.7	-2.1	-1.0	-1.8	-1.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.1	-0.0	0.4	-0.1	0.7	-1.1	0.3	-0.4	0.4	0.1	-0.4	-0.2	-0.1	-0.6
Medication: Aspirin	0.5	0.7	3.6	0.2	1.2	-1.1	-1.3	0.4	-0.2	-0.0	0.2	-0.4	0.3	0.2	1.9	0.1
Supplements: Vitamin C	0.5	0.6	2.4	-0.1	0.8	0.5	0.0	1.6	0.5	0.9	0.8	0.7	0.9	0.6	1.1	0.6
Knee pain experienced in last month	0.3	0.5	1.7	0.8	-0.5	-0.3	-0.7	1.3	-0.6	0.6	0.6	-1.2	-0.5	-0.7	-0.6	-0.7
Hypertension (Self-reported)	0.3	0.8	2.0	1.3	1.4	0.0	-0.0	1.0	0.7	0.8	0.2	-0.2	1.4	0.2	1.3	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	4.5	-0.5	-0.7	-1.4	1.1	0.8	-0.6	-1.2	-2.1	-0.8	0.1	-1.2	0.7	-0.1
Illnesses of father: Heart disease	0.2	0.3	1.0	0.8	0.2	0.3	0.7	-0.3	0.5	1.0	-0.0	0.3	0.3	0.1	0.6	0.5
Illnesses of siblings: Diabetes	0.6	0.8	3.6	-0.3	-1.1	-0.9	-0.5	1.9	-0.8	-0.9	-0.6	-0.9	-0.5	-0.4	-0.7	-0.8
Smoking status: Previous	0.2	0.2	0.7	0.1	-0.8	-0.1	-0.8	-0.7	-0.4	-0.8	0.3	-0.3	-0.2	-0.2	0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.7	0.7	-0.3	-0.1	0.7	0.4	-0.0	-0.2	-0.7	0.3	-0.4	-0.1	-0.8	-0.5
Whole body fat-free mass	0.2	1.2	7.7	1.5	0.2	1.0	0.9	2.8	0.8	0.2	0.5	0.8	0.5	0.9	-0.6	0.8
Leg fat-free mass (right)	0.2	1.2	4.8	1.1	0.4	1.4	0.5	2.2	0.9	0.7	1.6	0.7	0.4	1.2	-0.5	0.8
Arm fat percentage (left)	0.2	0.6	3.0	0.4	-0.1	0.8	-0.9	1.1	0.2	0.8	1.7	0.1	0.6	0.6	0.3	0.6
Average weekly red wine intake	0.5	0.7	1.9	-0.4	-1.2	-0.6	-0.9	-0.2	-0.9	-1.4	-0.5	-0.5	-1.0	-0.5	-1.3	-0.7
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.3	-1.4	-0.1	-1.5	-0.1	-0.3	-0.5	-1.0	-1.5	-0.2	0.8	-1.1	0.3	0.1
Mood swings	0.3	0.5	1.5	0.5	0.3	-0.5	0.9	0.4	0.3	-0.9	-1.1	0.6	0.4	0.4	1.2	1.0
Loneliness, isolation	0.7	0.9	3.3	-0.8	-1.2	-0.7	0.5	0.5	-0.6	-1.8	-1.4	-1.0	0.0	-1.2	-0.8	-0.6
Long-standing illness, disability or infirmity	0.5	0.8	3.7	-0.7	0.5	-0.7	-1.0	-1.7	-0.2	0.5	0.4	-0.8	0.5	-0.3	1.9	0.2
Ever had bowel cancer screening	2.9	3.4	10.2	-1.1	-0.9	-3.2	-2.0	-1.2	-2.4	-2.1	-1.8	-2.1	-0.6	-2.3	-0.6	-1.8
Diabetes diagnosed by doctor	0.1	0.2	0.7	0.5	-0.4	0.0	0.6	0.1	0.2	-0.3	-0.8	0.3	0.8	0.3	0.6	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.0	-1.3	0.3	1.4	1.4	0.3	1.0	0.2	0.4	1.0	0.4	0.7	0.6	0.6
Friendships satisfaction	1.1	1.3	4.0	-0.0	-1.6	0.2	1.1	0.7	-0.4	-1.0	-0.9	-1.0	-2.0	-1.1	-1.5	-1.5
Qualifications: nursing, teaching	0.9	1.3	2.6	1.4	1.1	1.2	0.7	1.5	1.0	1.6	1.5	1.2	0.8	1.2	-0.1	0.7
Commuting to job workplace: Walk	0.7	0.7	2.8	0.0	1.0	1.0	0.3	1.0	0.8	1.7	1.2	-0.0	0.8	0.5	-0.4	0.7
Eye problems/disorders: Cataract	0.8	0.9	2.5	-0.5	1.2	0.8	0.2	-0.5	1.1	0.5	0.7	0.4	1.2	1.1	1.6	1.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.9	-1.7	0.8	-0.1	-0.5	1.4	-0.0	0.7	1.5	-0.6	0.1	-0.1	0.9	0.0
Medication for cholesterol	0.6	0.8	2.2	0.0	-1.4	-0.4	-0.6	1.1	-0.8	-1.1	-0.4	-0.2	-1.5	-0.2	-1.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.4	-1.2	-0.1	-0.2	-0.6	-0.3	-0.4	-0.7	0.8	-0.4	-0.3	-0.1	0.7	0.0
Back pain experienced in last month	0.3	0.4	1.5	-1.0	0.6	-0.1	-0.6	1.2	-0.2	0.4	1.0	-0.6	-0.5	-0.4	0.3	-0.2
Mineral and other dietary supplements	0.3	0.4	1.8	-0.3	0.3	0.3	1.2	1.4	0.2	-0.4	-0.7	0.7	0.4	0.0	-0.1	0.5
Breast cancer (self-reported)	0.3	0.3	1.6	1.3	-0.4	-0.1	-0.3	-0.9	-0.1	-0.9	-0.5	0.2	-0.3	0.3	0.0	0.1
Asthma (self-reported)	0.1	0.2	1.6	0.3	-0.5	-0.3	-0.4	1.3	-0.3	-0.0	-0.1	0.2	0.3	-0.2	0.2	0.1
Osteoporosis (self-reported)	0.7	0.8	2.0	0.6	-1.1	-1.3	-0.8	-0.0	-1.1	-1.4	-1.4	-0.6	-0.2	-0.6	-0.8	-0.7
Osteoarthritis (self-reported)	2.2	2.9	5.9	-2.1	-1.9	-1.2	-2.4	-0.3	-1.8	-1.2	0.2	-2.3	-2.4	-1.7	-1.0	-1.8
Medication: Aspirin	0.5	0.6	2.6	0.6	1.0	-1.2	-1.6	-0.2	-0.5	0.0	0.3	-0.6	-0.2	-0.1	1.3	-0.4
Medication: Gliclazide	0.4	0.4	1.6	-0.0	0.6	0.4	0.0	0.8	0.6	0.3	0.6	-0.2	1.3	0.6	1.1	0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	1.6	-0.4	-0.1	0.3	0.1	1.3	0.0	0.4	0.2	0.4	0.5	0.2	-1.1	-0.1
Smoking status: Current	0.5	0.7	2.4	0.7	-0.5	-0.9	0.4	-1.5	-0.3	-1.4	-1.5	-0.4	-0.9	-0.5	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	2.1	0.8	0.0	0.6	1.1	1.5	0.6	0.4	-0.2	0.7	0.2	0.3	-0.5	0.1
Whole body water mass	0.2	1.3	7.9	1.4	0.3	1.2	0.9	2.8	0.9	0.2	0.8	0.9	0.6	1.1	-0.5	0.8
Leg predicted mass (right)	0.2	1.2	4.7	1.1	0.4	1.5	0.5	2.2	0.9	0.7	1.5	0.7	0.5	1.2	-0.5	0.9
Arm fat mass (left)	0.1	0.6	3.0	0.9	-0.0	0.6	-0.5	1.7	0.3	0.6	1.2	0.2	0.7	0.6	0.1	0.7
Number of self-reported non-cancer illnesses	0.8	1.3	4.7	-0.1	-0.4	-2.2	-1.5	-1.6	-1.3	-0.8	-0.9	-1.2	0.3	-1.1	1.0	-0.8
Average weekly champagne plus white wine intake	0.6	0.8	3.9	-0.0	-1.2	-1.0	-1.0	-0.5	-1.4	-0.4	-0.2	-0.2	-0.1	-0.8	-2.0	-0.9
Miserableness	0.2	0.4	1.4	-0.7	-0.3	-0.5	0.2	1.2	-0.3	-0.6	-0.3	-1.0	-0.3	-1.1	-0.0	-0.2
Guilty feelings	0.4	0.6	3.6	-1.1	0.1	-0.1	-1.1	1.9	-0.3	0.0	0.7	-0.3	0.2	-0.2	-0.7	0.2
Wears glasses or contact lenses	1.6	1.8	4.8	0.7	1.7	0.4	1.1	-1.0	1.4	0.1	-0.2	1.5	1.7	1.3	2.2	2.1
Ever taken oral contraceptive pill	0.8	0.9	2.5	0.8	0.3	0.4	1.6	0.1	0.7	0.4	-0.8	1.0	1.6	0.8	1.3	1.3
Hearing aid user	0.4	0.4	2.8	-0.3	-0.4	-0.7	-0.5	1.7	-0.5	-0.6	-0.1	-0.6	-0.2	-0.2	0.6	-0.2
Mother’s age at death	1.3	1.6	3.8	-0.4	1.3	1.3	0.6	1.7	1.6	0.6	0.7	0.9	2.0	1.0	1.6	1.6
Financial situation satisfaction	0.3	0.4	1.9	-0.2	-0.1	-0.4	0.4	0.6	0.2	-0.9	-0.8	0.2	0.6	0.5	1.4	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.2	-1.5	0.0	-0.9	-0.8	-0.8	-0.8	-0.2	0.5	-1.0	-0.3	-0.7	0.1	-0.6
Commuting to job workplace: Public transport	0.7	0.8	3.1	-0.9	0.5	0.0	-1.5	-1.8	-0.3	1.2	1.1	-0.5	0.6	-0.3	-0.6	-0.2
Eye problems/disorders: Glaucoma	0.3	0.4	1.5	-0.8	-0.0	0.5	0.1	0.8	0.4	-0.0	0.3	0.2	0.8	0.3	1.2	0.8
Medication: Blood pressure	0.3	0.5	1.5	-0.7	0.9	0.7	0.1	0.2	0.6	1.2	1.0	-0.2	1.1	-0.2	0.8	0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.2	-1.1	-0.3	1.2	1.0	-0.2	0.8	0.1	0.7	0.6	0.4	1.1	1.5	0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.0	4.0	-0.3	-0.0	-0.3	-2.0	-0.8	-0.5	0.6	1.8	-1.6	-0.5	-0.5	-0.7	-1.0
High cholesterol (Self-reported)	1.7	3.0	10.0	-0.9	2.2	1.5	-1.3	-1.9	1.2	1.9	3.2	0.3	1.2	1.6	2.2	1.3
Medication: Bendroflumethiazide	1.5	2.2	5.2	0.8	2.1	1.2	0.3	-0.4	1.5	1.7	1.3	1.7	2.3	2.1	1.2	1.3
Medication: Paracetamol	1.6	2.4	5.4	-0.1	1.8	1.7	0.2	2.2	1.5	1.2	2.3	1.1	0.5	1.4	2.3	1.5
Medication: Lisinopril	0.2	0.3	1.5	-0.0	0.2	-1.2	-0.8	-0.2	-0.8	-0.2	-0.5	-0.6	-0.1	-0.4	0.3	-0.5
Medication: Atorvastatin	1.0	1.3	2.6	-1.5	-1.4	-1.2	0.1	-1.0	-1.1	-1.6	-1.6	-0.9	-0.9	-0.8	0.9	-1.1
Illnesses of father: High blood pressure	0.4	0.5	2.7	1.3	0.7	-0.1	0.3	1.6	0.4	0.3	-0.5	0.1	0.0	0.4	0.3	0.3
Alcohol drinker status: Never	0.9	1.1	3.5	-0.2	1.3	1.2	0.0	-0.3	1.0	0.7	1.1	1.3	0.6	1.9	1.5	1.0
Ever smoked	0.2	0.4	1.8	1.0	-0.3	-1.0	-0.5	-0.5	-0.6	-1.3	-0.6	-0.6	-0.4	-0.3	0.1	-0.1
Basal metabolic rate	0.2	1.3	8.1	1.4	0.3	1.1	0.7	2.8	0.9	0.4	0.9	0.8	0.6	1.1	-0.4	0.8
Leg fat percentage (left)	0.1	0.5	2.0	0.6	0.1	0.5	-0.7	1.4	0.2	0.7	1.1	0.1	0.4	0.4	0.7	0.5
Arm fat-free mass (left)	0.2	1.1	11.0	1.2	-0.2	0.5	0.7	3.3	0.3	-0.2	0.1	0.4	0.1	0.4	-0.6	0.2
Number of operations (self-reported)	2.8	4.2	9.2	-0.0	-2.0	-3.0	-2.1	-0.9	-2.6	-3.0	-2.4	-1.5	-2.2	-1.8	-1.1	-1.8
Average weekly beer plus cider intake	0.8	1.2	3.5	-0.8	-1.5	-0.5	-0.2	0.7	-0.9	-0.1	-0.4	-1.8	-1.9	-1.3	-0.6	-1.5
Irritability	1.1	1.8	4.4	-2.1	-1.4	-0.7	-1.7	0.2	-1.3	-1.2	0.4	-1.9	-1.9	-1.5	-0.4	-1.2
Risk taking	0.3	0.4	1.2	-1.0	0.1	0.9	0.2	1.1	0.6	0.4	0.6	0.2	0.5	-0.1	0.9	0.8
Ever had prostate specific antigen (PSA) test	2.5	2.9	8.1	1.3	1.9	1.1	2.8	0.7	2.1	1.4	-0.4	1.3	2.5	1.5	1.4	2.1
Fractured/broken bones in last 5 years	1.7	2.2	9.2	-1.1	-0.8	-2.1	0.8	-0.5	-1.0	-3.0	-2.8	-0.1	-0.2	-1.0	1.5	-0.5
Age started oral contraceptive pill	0.4	0.6	2.7	0.5	0.3	-1.4	0.0	-0.8	-0.4	-0.9	-1.6	-0.1	0.3	-0.5	0.5	-0.3
Diastolic blood pressure, automated reading	0.4	1.3	2.4	1.4	-1.5	-1.1	-1.1	1.4	-1.3	-0.9	-0.9	-0.9	0.3	-1.3	-1.5	-0.7
Ever depressed for a whole week	0.2	0.2	0.9	-0.6	0.2	-0.6	-1.0	-0.4	-0.5	-0.8	0.5	0.1	-0.2	0.0	0.3	0.0
Unable to work because of sickness or disability	0.7	0.9	4.0	-0.6	0.6	1.3	0.1	0.3	0.9	0.2	2.0	0.2	0.4	0.8	1.7	0.9
Commuting to job workplace: Cycle	0.2	0.2	0.7	0.5	0.4	-0.8	0.2	-0.3	-0.4	-0.5	-0.8	0.3	0.3	0.3	-0.5	0.0
Myopia	1.0	1.5	4.1	-2.0	-1.3	-1.4	-1.5	-1.0	-1.5	-1.2	-0.9	-0.9	-0.9	-0.7	-0.7	-1.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.2	-1.5	-1.4	0.1	-0.2	-0.3	-0.6	-1.0	-0.2	0.3	-1.2	-0.2	-1.4	-0.5
Cholesterol lowering medication	1.4	2.0	8.1	-0.1	1.3	1.7	-0.7	-2.0	1.1	2.2	2.9	0.2	0.6	1.1	0.8	0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	6.8	-0.1	0.8	-0.3	0.7	0.7	0.4	0.2	-0.4	-0.3	1.0	-0.5	2.6	0.8
Pain experienced in last month	0.4	0.7	2.1	1.4	0.4	0.4	1.5	-0.8	0.7	0.1	-0.7	1.1	0.7	0.8	0.3	0.5
Supplements: Calcium	0.1	0.1	0.8	0.2	0.4	-0.4	0.2	-0.4	-0.0	-0.9	-0.3	-0.1	-0.0	0.1	0.6	0.1
Basal cell carcinoma (self-reported)	0.5	0.6	2.5	0.0	-0.1	-0.1	-1.3	-1.3	-0.5	-0.4	0.5	-0.3	-1.0	-0.4	-1.6	-0.6
Heart attack/myocardial infarction (self-reported)	1.4	1.9	5.2	-0.1	-0.8	-2.3	-1.0	-1.1	-1.8	-1.3	-1.9	-1.4	-1.6	-1.1	-0.2	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	3.7	1.0	1.6	1.9	1.8	0.9	1.6	1.9	1.3	1.9	1.5	1.9	0.4	1.5
Heart disease (siblings)	0.5	0.6	2.1	1.5	0.4	0.5	1.3	0.1	0.7	1.3	-0.5	1.0	0.1	0.9	-0.2	-0.0
Alcohol drinker status: Previous	0.9	1.0	3.0	-0.3	-0.5	1.3	1.7	1.6	1.1	0.1	-0.8	1.1	0.8	0.6	-0.3	1.3
Pack years of smoking	1.0	1.5	2.8	-0.1	-0.8	-1.7	-1.7	1.6	-1.4	-1.6	-1.0	-1.1	-1.3	-1.0	0.7	-0.5
Impedance of whole body	0.2	1.0	3.3	-0.3	-0.3	-1.6	-0.6	-1.8	-1.0	-0.1	-1.2	-0.8	-1.2	-0.7	-0.4	-1.2
Leg fat mass (left)	0.2	0.8	3.4	1.1	0.2	0.8	-0.5	1.8	0.5	0.8	1.4	0.2	0.6	0.7	0.5	0.7
Arm predicted mass (left)	0.2	0.9	8.3	1.3	-0.1	0.7	0.6	2.9	0.4	-0.1	0.2	0.5	0.3	0.6	-0.5	0.4