TWAS hub - ATF7IP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2670	0.0380	0.0e+00	0.252	0.197	0.262	0.251	0.252	2.1e-30	1.7e-23	1.0e-31	2.3e-30	1.8e-30
2	GTEx	Adipose Subcutaneous	0.2440	0.0460	1.4e-08	0.131	NA	0.133	NA	0.172	7.6e-11	NA	5.8e-11	NA	5.7e-14
3	GTEx	Breast Mammary Tissue	0.2620	0.0670	4.8e-04	0.147	NA	0.104	NA	0.125	5.5e-08	NA	5.6e-06	NA	5.5e-07
4	GTEx	Breast Mammary Tissue (Female)	0.2056	0.0894	2.2e-02	0.158	NA	0.023	NA	0.114	1.9e-05	NA	6.7e-02	NA	2.9e-04
5	GTEx	Esophagus Mucosa	0.3750	0.0610	2.2e-08	0.170	NA	0.166	NA	0.163	1.9e-11	NA	3.2e-11	NA	4.8e-11
6	GTEx	Skin Not Sun Exposed Suprapubic	0.3620	0.0770	3.5e-05	0.166	NA	0.085	NA	0.136	2.1e-09	NA	2.0e-05	NA	6.8e-08
7	GTEx	Skin Sun Exposed Lower leg	0.2600	0.0480	7.7e-08	0.175	NA	0.187	NA	0.184	2.1e-14	NA	2.1e-15	NA	4.1e-15
8	GTEx	Spleen	0.3100	0.1010	6.6e-04	0.112	NA	0.156	NA	0.099	8.3e-04	NA	8.2e-05	NA	1.7e-03
9	GTEx	Thyroid	0.2730	0.0750	7.8e-05	0.033	NA	0.079	NA	0.055	1.5e-03	NA	1.2e-06	NA	4.8e-05
10	METSIM	Adipose	0.0974	0.0304	9.1e-04	0.044	0.009	0.033	0.033	0.036	3.3e-07	1.3e-02	8.6e-06	8.2e-06	3.1e-06
11	ROSMAP	Brain Pre-frontal Cortex	0.0778	0.0259	2.7e-04	0.024	0.028	0.026	0.026	0.030	3.7e-04	1.5e-04	2.5e-04	2.3e-04	8.8e-05
12	YFS	Blood	0.1118	0.0233	4.4e-10	0.032	0.045	0.056	0.059	0.054	7.5e-11	1.2e-14	7.3e-18	1.4e-18	4.4e-17
13	TCGA	Thyroid Carcinoma	0.1490	0.0480	3.9e-12	0.100	0.112	0.132	NA	0.135	6.0e-10	4.9e-11	7.6e-13	NA	4.4e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Ever smoked	4.1	7.2	14.6	-3.8	3.8	2.6	2.0	2.5	2.8	2.7	0.5	0.5	2.7	-2.9	-2.0	3.6
Medication for hormone replacement therapy	3.5	3.9	6.7	-2.0	2.3	2.2	2.6	1.9	2.4	1.8	1.2	-0.6	2.3	-0.4	-2.3	2.3
Smoking status: Current	3.3	5.2	9.1	-2.9	3.0	2.2	2.1	2.3	2.2	2.3	1.8	0.4	2.1	-2.2	-1.8	3.0
Medication: Metformin	3.1	4.3	7.4	2.1	-2.6	-2.1	-2.1	-2.7	-1.9	-2.0	1.1	-1.7	-1.9	1.2	2.2	-2.6
Angina (self-reported)	3.0	3.9	7.1	2.6	-2.6	-2.2	-1.5	-1.8	-2.2	-2.0	0.8	-0.3	-2.5	1.5	1.5	-2.7
Financial situation satisfaction	3.0	3.7	6.0	-1.4	2.2	2.4	2.5	2.4	2.4	2.2	0.7	0.9	2.0	-0.3	-2.0	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	13.6	2.1	-2.4	-1.2	-1.2	-1.0	-1.2	-0.9	-3.7	0.3	-1.1	1.8	2.3	-2.0
Medication: Co-codamol	2.7	3.1	5.6	0.1	-0.8	-2.4	-2.2	-2.3	-2.1	-2.0	1.4	-0.7	-2.4	-1.5	2.1	-1.1
Qualifications: nursing, teaching	2.7	4.2	8.1	2.5	-2.3	-1.6	-1.7	-2.3	-1.6	-1.6	2.8	-1.9	-1.8	2.0	1.7	-2.3
Medication: Lansoprazole	2.6	2.9	5.9	2.0	-2.4	-1.6	-1.7	-1.4	-1.9	-1.4	-0.7	-1.4	-1.7	1.2	2.0	-2.1
Emphysema/chronic bronchitis	2.6	3.0	5.7	2.1	-2.1	-1.7	-1.8	-1.3	-1.7	-1.6	0.3	-1.0	-1.5	1.6	2.4	-2.0
Ever had hysterectomy (womb removed)	2.4	2.7	5.8	-0.6	1.2	2.0	2.3	1.5	1.9	1.5	-0.5	1.1	2.4	0.8	-2.3	1.5
Angina	2.4	3.2	5.7	2.3	-2.3	-2.0	-1.4	-1.7	-2.1	-1.8	0.7	-0.1	-2.3	1.2	1.2	-2.4
Ulcerative Colitis (UC)	2.3	4.3	10.0	-3.1	3.2	1.7	2.1	1.9	1.8	1.3	0.2	0.7	1.5	-2.6	-1.8	2.8
HbA1C	2.2	2.4	4.6	1.5	-1.4	-1.6	-1.1	-2.0	-1.8	-1.6	2.1	-0.5	-1.5	0.4	2.2	-1.5
Family relationship satisfaction	2.2	2.8	5.3	-1.6	1.9	1.9	1.8	1.5	1.6	0.9	-2.3	0.9	1.5	-0.8	-2.0	2.1
Medication: Atenolol	2.1	2.6	4.7	1.5	-1.9	-2.2	-1.8	-1.8	-2.0	-1.4	0.9	-1.2	-2.0	-0.1	0.7	-2.0
Glaucoma (self-reported)	2.1	2.5	4.7	1.0	-1.5	-1.8	-1.9	-1.9	-1.8	-2.2	0.4	-1.7	-1.4	0.5	1.6	-1.6
Age at First Birth	2.0	2.9	6.4	-0.5	1.0	2.4	1.8	2.5	2.5	1.9	-1.4	-0.2	2.0	0.9	-1.5	1.5
Current tobacco smoking	2.0	3.2	5.9	-2.4	2.4	1.6	1.5	1.8	1.6	1.8	1.7	0.2	1.6	-1.9	-1.3	2.3
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	4.2	-2.1	2.0	1.4	1.3	1.8	1.5	1.0	0.2	0.7	1.5	-1.3	-0.9	1.9
Father’s age at death	2.0	2.7	6.1	-0.8	1.4	2.1	2.0	2.5	1.9	1.9	0.5	1.5	2.1	-0.0	-1.5	1.5
Pack years adult smoking proportion	1.9	2.9	6.8	0.6	-1.6	-2.3	-2.6	-2.0	-2.3	-1.7	0.7	0.2	-2.2	-0.4	1.5	-1.6
Pain type(s) experienced in last month: Hip pain	1.9	2.3	3.5	-1.9	1.8	1.6	1.4	1.4	1.9	1.4	-0.7	1.7	1.4	-1.1	-1.3	1.9
Serious illness, injury or assault to yourself	1.8	2.2	4.2	1.2	-1.4	-2.0	-2.0	-1.6	-2.1	-1.8	0.2	-1.0	-1.8	-0.1	0.9	-1.6
Supplements: Glucosamine	1.8	2.3	4.5	-0.9	1.4	2.0	1.5	2.1	1.9	2.1	0.2	-0.4	2.0	0.1	-1.2	1.6
Mean time to correctly identify matches	1.7	3.2	7.7	1.8	-2.3	-1.7	-1.7	-2.0	-1.5	-1.8	-0.3	-0.5	-1.6	1.3	2.8	-2.2
Suffer from ‘nerves’	1.7	2.6	4.4	-1.6	1.7	1.9	2.0	1.7	1.6	1.8	0.5	1.1	1.8	-0.3	-2.1	1.8
Mother’s age at death	1.7	2.1	4.1	-1.6	1.7	1.5	0.7	1.6	1.3	1.5	-0.4	2.0	1.1	-1.2	-2.0	1.6
Pack years of smoking	1.7	2.5	6.0	0.3	-1.4	-2.1	-2.4	-1.8	-2.2	-1.5	0.8	0.4	-2.0	-0.6	1.6	-1.4
Prostate Cancer	1.6	2.2	4.2	1.4	-1.5	-1.3	-2.0	-1.4	-1.2	-1.7	-0.1	-1.6	-1.2	1.3	2.0	-1.6
High blood pressure (mother)	1.6	2.3	4.8	-1.4	1.6	1.4	2.2	1.5	1.5	1.9	-0.6	1.1	1.3	-1.3	-1.6	1.7
Diabetes (self-reported)	1.6	2.4	5.3	1.8	-2.0	-1.5	-1.0	-2.3	-1.3	-1.5	1.1	-1.7	-1.3	1.0	1.3	-1.9
Gout (self-reported)	1.6	2.1	4.4	-0.8	1.1	1.7	1.2	1.4	1.7	1.9	0.6	1.6	2.0	-0.1	-2.1	1.3
Alcohol drinker status: Never	1.6	2.0	3.3	-1.1	1.4	1.5	1.8	1.1	1.6	1.2	-0.8	1.8	1.7	-0.1	-1.7	1.6
Townsend deprivation index at recruitment	1.5	2.1	4.8	-1.3	1.9	1.9	1.4	1.4	2.2	1.4	-0.4	-0.9	1.8	0.2	-0.4	1.8
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	2.9	1.7	-1.6	-1.2	-0.6	-1.4	-1.2	-1.2	1.0	-1.4	-0.9	1.5	1.7	-1.6
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.6	1.7	-1.9	-1.1	-1.2	-1.5	-1.0	-0.8	0.9	-1.6	-1.1	1.1	1.8	-1.7
Ovarian Cancer	1.4	1.9	4.3	-1.9	2.1	1.1	0.8	1.2	1.3	1.4	-0.7	0.7	1.4	-1.5	-0.9	1.8
Alcohol usually taken with meals	1.4	2.2	4.4	0.5	-0.0	2.0	1.5	1.8	2.0	1.7	-0.8	-1.4	2.1	2.0	-1.2	0.5
Prospective memory result	1.4	1.8	3.1	1.3	-1.6	-1.4	-1.4	-1.8	-1.3	-1.4	-0.5	-1.4	-1.5	0.5	1.2	-1.5
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.7	-1.9	1.9	1.2	1.0	0.3	1.2	0.7	0.7	0.0	1.1	-1.7	-1.7	1.8
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	12.2	-0.9	1.3	1.3	1.2	1.3	1.0	1.7	3.5	0.1	1.1	-1.2	-0.8	1.4
Medication: Allopurinol	1.4	1.8	5.2	0.1	0.5	1.6	1.3	1.2	1.8	1.8	0.2	1.2	1.9	0.8	-2.3	0.7
Osteoarthritis (self-reported)	1.4	1.8	3.7	-1.2	1.3	1.6	0.9	1.6	1.9	1.8	1.7	0.7	1.0	-0.2	-0.8	1.6
Fractured/broken bones in last 5 years	1.4	1.8	3.9	1.9	-2.0	-1.0	-1.4	-1.1	-0.8	-0.6	0.5	-1.4	-1.1	1.6	0.9	-1.9
Reaction Time	1.3	2.5	7.7	1.4	-2.0	-1.5	-1.4	-1.8	-1.5	-1.4	0.2	-0.7	-1.4	0.9	2.8	-2.0
Breast Cancer	1.3	3.1	7.9	-1.2	1.4	2.5	2.6	1.5	2.6	1.6	0.6	-0.9	2.8	0.2	-1.0	1.7
Smoking Status	1.3	3.1	6.3	-2.5	2.3	1.7	1.1	1.7	1.9	1.9	-0.1	0.3	1.5	-2.2	-1.4	2.2
Hair/balding pattern: Pattern 3	1.3	2.0	7.1	1.1	-1.2	-1.5	-1.6	-1.5	-1.7	-1.0	2.7	-0.4	-1.2	-0.1	1.4	-1.2
Hearing aid user	1.3	1.4	3.4	0.8	-1.3	-1.5	-1.7	-1.5	-1.3	-0.9	-0.8	0.2	-1.9	0.0	0.5	-1.4
Relative age voice broke	1.2	1.8	4.1	-2.0	1.7	1.5	0.7	1.3	1.4	1.4	-0.9	-0.3	1.9	-0.8	-0.8	1.6
Age when periods started (menarche)	1.2	2.8	6.2	1.3	-2.0	-1.7	-1.8	-1.4	-1.6	-1.4	-2.5	-1.3	-2.0	1.1	1.1	-2.0
Past tobacco smoking	1.2	2.2	6.3	2.5	-2.2	-1.2	-0.6	-0.9	-1.4	-1.4	0.2	-0.4	-1.2	2.2	0.9	-1.9
Worrier / anxious feelings	1.2	2.2	3.6	-1.3	1.3	1.7	1.4	1.6	1.7	1.3	-1.5	1.4	1.9	0.1	-1.9	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.3	0.8	-1.1	-1.4	-1.5	-1.5	-1.4	-1.0	1.3	-0.8	-1.5	0.6	0.2	-1.2
Medication: Amlodipine	1.2	1.7	3.3	1.2	-1.5	-1.7	-1.8	-1.7	-1.4	-0.8	1.1	-0.6	-1.5	0.3	0.6	-1.6
Arm fat percentage (left)	1.2	4.6	7.8	1.1	-1.7	-2.7	-2.7	-2.8	-2.4	-2.4	2.3	-1.6	-2.5	-0.4	2.1	-2.0
Ulcerative Colitis	1.1	1.5	5.0	-2.2	2.0	0.8	1.0	0.9	1.0	0.3	-0.3	0.3	0.7	-1.7	-0.8	1.7
Impedance of leg (left)	1.1	5.3	26.1	-1.0	1.5	2.5	2.5	2.4	2.2	1.1	-5.1	0.7	2.7	1.0	-1.7	1.7
Hair/balding pattern: Pattern 2	1.1	1.4	3.6	0.3	-0.5	-1.3	-0.7	-1.6	-1.2	-1.7	-0.6	-1.9	-1.4	0.1	1.7	-0.7
Pain all over the body in last month	1.1	1.2	2.6	-1.1	1.4	1.4	1.1	0.6	1.3	0.8	-1.2	0.1	1.4	-0.2	-0.9	1.6
Exposure to tobacco smoke at home	1.1	1.2	3.0	-1.4	1.7	1.0	0.5	0.7	1.0	0.7	0.1	0.4	1.2	-1.3	-1.1	1.6
Diabetes diagnosed by doctor	1.1	1.7	4.5	1.4	-1.6	-1.2	-1.0	-2.1	-0.9	-1.0	1.6	-1.4	-1.0	0.8	0.9	-1.5
Medication: Aspirin	1.1	1.4	3.1	1.7	-1.7	-1.3	-0.2	-1.5	-1.0	-1.2	0.3	0.4	-1.2	0.7	0.8	-1.8
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.6	1.1	-1.1	-1.4	-1.4	-1.5	-1.6	-0.9	0.1	0.6	-1.2	0.1	0.7	-1.1
Supplements: Zinc	1.0	1.1	11.9	-0.4	0.5	0.6	-0.1	0.8	0.5	0.1	-3.5	-0.4	0.5	-0.2	-0.0	0.5
Diabetes (mother)	1.0	1.3	3.3	-0.7	0.2	-1.4	-1.4	-0.8	-1.3	-1.4	-0.7	0.3	-1.7	-1.8	0.7	-0.2
Trunk fat percentage	1.0	3.9	7.2	1.1	-1.7	-2.5	-2.6	-2.7	-2.3	-2.5	0.6	-1.1	-2.3	-0.1	1.9	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.4	2.1	-2.1	-1.0	-1.3	-0.6	-1.1	-0.7	-1.7	1.8	-1.0	2.1	-0.4	-2.0
Qualifications: CSEs or equivalent	1.0	1.3	3.2	0.1	-0.3	-1.5	-0.5	-1.2	-1.4	-1.3	1.7	0.2	-1.4	-1.8	0.9	-0.7
Number of incorrect matches in round	1.0	1.6	16.8	0.6	-0.7	0.3	0.2	0.0	0.3	-0.2	-4.1	1.4	0.1	0.9	-0.1	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.9	-0.2	0.3	1.4	0.9	1.3	1.4	1.3	-1.2	0.2	1.2	1.3	-1.7	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.0	-1.7	1.5	1.2	1.1	1.1	0.9	0.7	0.5	-0.6	1.1	-1.0	-1.2	1.6
Medication: Blood pressure	1.0	1.7	3.0	1.2	-1.6	-1.5	-1.7	-1.6	-1.3	-0.6	1.3	-1.4	-1.5	0.4	0.3	-1.5
Average weekly red wine intake	1.0	1.5	3.8	-0.9	0.6	1.4	0.8	1.9	1.5	1.6	-1.7	-0.6	1.5	0.3	-0.7	0.9
Medication: Gliclazide	1.0	1.1	3.6	1.2	-1.9	-0.8	-0.5	-1.2	-0.6	-0.8	0.3	0.5	-0.9	0.8	1.2	-1.5
Arm fat mass (left)	1.0	4.0	6.9	0.6	-1.2	-2.5	-2.5	-2.5	-2.3	-2.1	2.6	-1.1	-2.5	-1.1	1.7	-1.6
Medication: Paracetamol	1.0	1.5	2.6	-1.5	1.2	1.3	1.5	0.8	1.4	1.2	-0.0	1.6	1.3	-1.2	-1.0	1.4
Medication: Lisinopril	1.0	1.3	2.8	1.5	-1.5	-0.8	-0.7	-1.1	-0.8	-0.7	-0.1	-1.0	-0.3	1.5	1.7	-1.5
Irritability	1.0	1.7	3.4	-1.6	1.8	1.4	0.9	1.4	1.3	1.4	0.2	-0.9	1.2	-0.8	-1.5	1.8
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	-1.2	0.9	0.9	0.9	1.1	1.2	0.9	-1.5	1.3	1.2	-1.0	-0.3	1.0
Alcohol drinker status: Previous	1.0	1.2	2.9	-1.7	1.3	1.0	0.9	0.5	1.1	0.7	-0.2	-1.3	1.2	-1.1	-0.7	1.3
Schizophrenia vs Biploar Disorder	0.9	1.1	3.9	-2.0	1.7	0.8	0.6	0.8	0.6	0.8	0.6	0.1	0.5	-1.6	-0.6	1.5
Type 2 Diabetes (T2D) (2018)	0.9	1.6	4.9	1.3	-1.4	-1.0	-1.1	-1.6	-0.7	-0.8	1.4	-2.2	-0.6	1.0	1.0	-1.3
Impedance of leg (right)	0.9	4.4	27.0	-0.9	1.4	2.1	2.0	2.1	1.8	0.6	-5.2	0.2	2.4	1.0	-1.3	1.5
Taking other prescription medications	0.9	1.5	4.7	0.0	-0.7	-1.5	-1.8	-2.2	-1.4	-0.9	1.1	-0.3	-1.5	-1.3	0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.2	0.3	-0.9	-1.2	-1.5	-1.4	-1.0	-1.3	-0.2	-0.1	-1.3	0.1	1.4	-1.0
Medication: Ramipril	0.9	1.1	2.3	1.1	-1.2	-1.1	-1.5	-0.6	-1.0	-0.9	0.2	-1.4	-1.1	1.2	-0.2	-1.3
Falls in the last year	0.9	1.3	4.7	0.2	0.2	1.3	1.0	1.1	1.4	1.1	1.1	-2.2	1.4	1.1	0.2	0.5
Qualifications: A levels/AS levels or equivalent	0.9	2.1	17.1	-0.6	1.2	0.8	0.2	1.0	0.7	1.1	4.1	-0.8	0.5	-0.5	-1.6	1.0
Arm fat mass (right)	0.9	3.5	6.2	0.6	-1.1	-2.4	-2.5	-2.3	-2.1	-2.0	2.4	-1.2	-2.3	-1.0	1.5	-1.5
Medication: Paracetamol	0.9	1.5	3.2	-1.4	1.0	1.2	1.6	0.7	1.3	1.2	0.3	1.8	1.2	-0.9	-1.2	1.2
Exposure to tobacco smoke outside home	0.9	1.1	4.0	0.1	0.3	1.2	0.6	1.3	1.3	1.4	0.3	1.0	1.1	0.9	-2.0	0.7
Medication: Ibuprofen	0.9	1.0	3.4	-0.3	0.3	1.2	0.9	1.4	1.2	1.4	0.0	0.3	1.0	1.0	-1.8	0.4
Medication: Aspirin	0.9	1.1	2.2	1.4	-1.4	-1.3	-0.4	-1.3	-1.0	-1.3	0.7	0.3	-1.2	0.4	0.2	-1.5
Depression (Nagel 2018)	0.8	1.2	3.2	1.5	-1.3	-0.9	-0.8	-1.3	-1.0	-0.7	1.8	-0.7	-0.7	0.9	1.0	-1.3
Major Depression (MDD)	0.8	1.0	6.0	1.4	-1.0	-0.2	0.0	-0.5	-0.1	-0.6	2.4	0.3	-0.1	1.3	0.6	-0.8
Trunk fat mass	0.8	3.4	6.1	0.7	-1.3	-2.3	-2.5	-2.5	-2.2	-2.3	1.5	-0.9	-2.2	-0.7	1.7	-1.7
Waist circumference	0.8	3.0	5.0	1.2	-1.5	-2.1	-2.1	-2.1	-1.8	-1.9	1.7	-1.4	-2.2	-0.2	1.6	-1.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.6	-1.3	1.4	0.8	1.2	0.7	0.7	0.6	0.9	-0.7	1.0	-1.6	-0.3	1.5
Arm fat percentage (right)	0.8	3.0	5.6	0.5	-1.0	-2.2	-2.4	-2.2	-1.9	-1.9	2.0	-1.2	-2.1	-0.9	1.5	-1.4
Depression (self-reported)	0.8	0.9	2.9	-0.2	0.1	-0.9	-0.8	-1.2	-1.0	-0.8	1.7	-0.3	-1.2	-1.4	0.8	0.1
Loud music exposure frequency	0.8	0.9	1.8	0.4	-0.7	-1.1	-1.3	-1.1	-1.3	-0.8	0.7	-1.1	-1.3	-0.2	0.3	-0.8
Number of children fathered	0.8	0.9	3.2	1.7	-1.4	-0.4	0.1	-0.8	-0.2	-0.8	0.4	-0.7	-0.4	1.8	0.4	-1.3
Guilty feelings	0.8	1.2	2.3	-1.0	1.1	1.5	0.8	1.4	1.4	1.4	-0.4	0.6	1.4	-0.1	-1.0	1.3
Lupus	0.7	1.0	2.8	1.1	-0.6	0.8	1.2	0.5	0.8	0.7	-1.7	1.0	1.1	1.7	-0.4	-0.4
Blood Red Count	0.7	7.2	21.3	4.4	-3.9	-1.9	-1.6	-1.6	-2.1	-2.6	-0.1	-0.7	-1.9	4.6	0.7	-3.7
Blood White Count	0.7	5.0	9.7	2.3	-3.0	-2.2	-2.2	-1.8	-2.2	-2.0	0.6	-2.1	-1.9	2.1	2.6	-3.1
Vitamin and mineral supplements	0.7	1.0	3.9	1.1	-0.7	-0.1	0.1	0.1	-0.0	0.1	2.0	1.7	-0.5	0.9	-1.6	-0.6
Body mass index (BMI)	0.7	3.0	11.1	0.8	-1.2	-2.0	-2.0	-2.1	-1.7	-1.6	3.3	-0.9	-2.0	-0.6	0.9	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.7	2.2	-1.9	-0.3	-0.3	-0.0	-0.3	0.1	-1.3	2.1	-0.4	2.2	-0.8	-1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.2	-1.6	1.3	0.2	0.6	-0.5	0.1	0.0	1.0	-0.2	-0.1	-1.8	-0.8	1.4
Heart attack	0.7	0.9	3.0	1.4	-1.2	-0.0	0.4	-0.4	0.2	-0.1	-1.3	-1.4	0.1	1.7	0.2	-1.1
Weight	0.7	3.4	8.5	0.2	-0.8	-2.2	-2.2	-2.2	-2.2	-1.9	2.9	-0.4	-2.5	-1.6	1.2	-1.2
Happiness	0.7	0.9	2.5	-1.5	1.4	0.3	0.3	0.3	0.0	0.1	1.1	1.0	-0.3	-1.6	-0.8	1.2
Mouth/teeth dental problems: Dentures	0.7	1.2	2.0	1.3	-1.4	-1.1	-1.2	-0.9	-0.8	-0.9	-1.1	-0.1	-1.1	1.4	0.6	-1.4
Impedance of arm (left)	0.7	3.1	15.8	1.1	-1.5	-1.2	-1.0	-1.2	-1.4	-1.7	-4.0	-1.5	-0.9	1.3	2.2	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.1	-1.4	1.1	0.7	1.2	0.8	0.6	0.6	1.8	0.9	1.0	-1.2	0.2	1.1
Comparative body size at age 10	0.7	1.8	7.5	0.8	-0.9	-1.5	-0.9	-1.4	-1.2	-1.6	2.7	-1.4	-1.5	-0.4	0.8	-1.0
Number of full brothers	0.7	0.9	2.3	0.3	-0.4	-1.2	-0.7	-1.2	-1.0	-1.5	-1.3	0.3	-1.1	0.1	1.1	-0.8
Migraine (self-reported)	0.7	0.9	2.5	0.6	-0.3	1.1	1.0	1.0	1.1	1.3	-0.7	-0.7	1.2	1.6	0.2	0.1
Whole body fat mass	0.7	3.0	5.2	0.6	-1.1	-2.2	-2.3	-2.2	-2.0	-2.1	1.8	-0.8	-2.2	-0.8	1.4	-1.5
Had major operations	0.7	0.8	5.1	1.2	-1.2	0.1	-0.5	-0.2	0.0	-0.1	-0.9	0.7	0.1	2.3	0.4	-1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	-0.5	1.0	0.8	0.9	1.3	0.9	0.6	0.5	0.7	0.6	-0.5	-1.5	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.8	0.3	0.2	0.9	0.7	0.4	1.0	1.3	0.0	1.0	0.6	1.2	-1.7	0.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.0	-0.5	0.9	0.9	0.9	1.1	0.8	1.0	-0.9	1.4	1.2	-0.2	-0.3	1.0
Risk taking	0.7	1.0	4.5	0.8	-1.1	-0.7	-0.5	-0.9	-0.6	-0.4	-0.5	-2.1	-0.9	0.8	1.1	-0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.0	1.4	-1.2	0.1	0.5	-0.3	0.3	-0.0	-1.2	-1.4	0.3	1.7	0.2	-1.0
Bipolar Disorder (2011)	0.6	0.6	3.7	0.8	-0.7	-0.5	-0.3	-0.6	-0.4	-0.7	-1.9	0.4	-0.4	0.6	0.5	-0.6
Mean Putamen Volume	0.6	0.7	1.6	-0.4	0.7	1.0	0.8	1.1	0.9	1.3	0.8	0.1	1.2	0.2	0.1	0.8
Waist Hip Ratio (WHR)	0.6	2.9	8.3	2.5	-2.2	-0.5	-0.9	-0.6	-0.2	-0.1	-2.3	-2.5	-0.6	2.9	1.0	-1.9
Cardiovascular Disease	0.6	2.0	4.7	1.2	-1.3	-1.6	-1.7	-1.3	-1.6	-0.9	1.5	-2.2	-1.4	0.4	1.3	-1.4
Leg fat-free mass (left)	0.6	3.3	16.8	0.1	-0.5	-1.9	-1.7	-1.8	-2.0	-1.3	4.1	0.0	-2.3	-1.8	1.2	-1.0
Average weekly fortified wine intake	0.6	0.7	2.6	-1.0	0.9	0.6	0.3	0.4	0.6	0.7	1.6	-1.2	0.5	-0.5	1.1	0.9
Leg predicted mass (left)	0.6	3.2	16.8	0.1	-0.4	-1.9	-1.7	-1.8	-1.9	-1.2	4.1	0.1	-2.2	-1.8	1.0	-0.9
Financial difficulties in last 2 years	0.6	0.8	3.7	-1.8	1.1	-0.2	-0.4	-0.3	-0.1	0.4	-1.2	0.4	-0.3	-1.9	0.0	0.9
Time employed in main current job	0.6	0.6	2.0	0.9	-0.7	-0.6	-0.7	-0.4	-0.5	-0.6	1.4	-1.4	-0.8	0.2	-0.6	-0.7
Illnesses of mother	0.6	0.8	2.6	0.2	-0.4	-0.7	-1.4	-0.9	-0.7	-1.0	1.6	-1.0	-0.8	-0.3	0.5	-0.5
Hair/balding pattern: Pattern 4	0.6	1.6	3.4	0.4	-0.1	1.4	1.3	1.8	1.4	1.6	-1.0	1.6	1.4	0.5	-1.6	0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.6	-0.1	0.8	1.3	1.6	1.5	1.1	0.4	-0.9	1.1	1.2	0.5	-0.3	0.8
Body fat percentage	0.6	2.2	4.4	0.7	-1.2	-1.9	-2.0	-2.1	-1.7	-2.0	1.1	-0.8	-1.7	-0.3	1.3	-1.5
Medication: Seretide 50 evohaler	0.6	0.7	2.3	0.8	-0.9	-0.6	-0.4	-1.4	-0.4	-0.6	-1.5	-0.1	-0.6	0.5	0.8	-0.9
Leg fat mass (right)	0.6	2.4	6.6	0.5	-0.9	-1.9	-1.9	-2.0	-1.7	-1.9	2.6	-0.5	-1.9	-0.7	0.8	-1.3
Supplements: Vitamin C	0.6	0.7	2.7	-1.2	0.8	0.5	0.4	0.6	0.6	0.4	-1.2	-1.6	0.6	-0.3	0.4	0.8
Leg fat-free mass (right)	0.6	3.1	18.7	-0.1	-0.3	-1.7	-1.5	-1.6	-1.7	-1.0	4.3	0.3	-2.1	-1.9	1.0	-0.8
Handedness (chirality/laterality): Left-handed	0.6	0.7	3.6	0.1	0.0	-0.5	-1.3	-0.4	-0.3	-0.5	1.4	-1.9	-0.9	-0.1	-0.2	-0.2
Loneliness, isolation	0.6	0.8	2.5	0.2	-0.3	-0.8	-1.0	-1.4	-0.8	-1.0	0.3	-1.6	-1.1	-0.2	0.8	-0.6
Friendships satisfaction	0.6	0.7	1.5	-1.2	1.2	0.7	0.5	0.9	0.5	-0.1	1.2	-0.2	0.7	-1.0	-0.3	1.2
Breast cancer (self-reported)	0.6	0.7	2.8	-1.1	0.6	-0.5	-0.3	-0.8	-0.6	-0.8	0.4	0.2	-0.1	-1.7	1.5	0.5
Leg predicted mass (right)	0.6	3.2	17.9	0.0	-0.4	-1.8	-1.6	-1.8	-1.9	-1.1	4.2	0.2	-2.2	-1.9	1.1	-0.9
Eye problems/disorders: Glaucoma	0.6	0.7	2.1	0.4	-0.6	-0.9	-1.0	-1.0	-1.0	-1.3	0.0	-1.5	-0.6	0.1	0.8	-0.7
Ever had prostate specific antigen (PSA) test	0.6	0.6	4.8	0.2	-0.7	-0.5	-0.6	-0.8	-0.3	-0.4	-2.2	0.9	-0.1	0.6	-0.1	-0.4
Bipolar Disorder or Schizophrenia	0.5	1.3	3.0	0.3	-0.6	-1.1	-1.0	-1.6	-1.3	-1.5	-1.5	-0.2	-1.2	-0.5	1.7	-0.7
Schizophrenia (2018)	0.5	1.0	2.8	-0.0	-0.3	-1.1	-0.8	-1.4	-1.2	-1.5	-0.7	-0.7	-1.0	-0.6	1.7	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.2	-1.0	0.9	0.5	0.4	0.1	0.5	0.6	1.4	1.5	0.6	-0.9	-0.5	0.8
Irritable Bowel Disease (IBD)	0.5	1.1	3.5	-1.9	1.6	0.7	1.4	0.8	0.8	0.3	-0.4	-0.5	0.8	-1.4	-0.6	1.3
Verbal and Numeric Reasoning (VNR)	0.5	1.1	12.1	0.5	-0.4	-0.1	-0.5	0.7	-0.1	0.7	3.5	0.2	-0.4	0.4	-0.4	-0.6
Fasting Glucose	0.5	0.5	3.4	0.2	-0.2	-0.2	-0.3	-0.4	-0.3	-0.4	1.7	-1.8	-0.2	0.2	0.5	-0.1
Respiratory disease	0.5	1.0	2.5	1.5	-1.2	-0.4	-0.6	-0.2	-0.4	-0.6	0.0	-1.6	-0.3	1.5	1.6	-1.1
Hand grip strength (left)	0.5	1.3	10.0	-0.6	1.0	-0.2	-0.0	-0.3	-0.4	-0.6	3.2	-0.9	-0.4	-1.7	-0.5	0.7
Sensitivity / hurt feelings	0.5	0.8	2.8	-0.5	0.4	0.8	0.3	0.8	1.0	1.3	1.4	1.0	0.5	-0.2	-1.7	0.4
Hearing difficulty/problems: Yes	0.5	0.7	1.4	0.7	-1.1	-0.9	-1.1	-0.7	-0.7	-0.5	-0.5	-0.3	-1.0	0.8	1.2	-1.0
Hand grip strength (right)	0.5	1.3	6.8	-0.6	0.7	-0.7	-0.3	-1.1	-1.0	-1.3	2.6	-0.9	-0.7	-1.7	0.5	0.3
Multivitamins +/- minerals	0.5	0.6	4.2	-0.6	0.8	0.4	0.5	0.4	0.3	0.4	-2.0	-0.3	0.8	-0.5	1.0	0.7
Stomach or abdominal pain in last month	0.5	0.6	2.9	-0.8	0.9	0.8	0.9	0.1	0.8	0.5	-1.7	-0.6	0.8	-0.3	-0.1	0.9
Number of live births	0.5	0.8	3.8	0.2	-0.5	-0.8	-1.5	-0.6	-0.6	-0.6	-1.9	-0.2	-1.1	0.7	-0.2	-0.4
Lung cancer (father)	0.5	0.6	2.2	0.4	-0.6	-0.9	-0.7	-1.5	-0.5	-0.7	0.1	-1.2	-0.6	0.2	0.7	-0.7
Birth weight of first child	0.5	0.9	2.8	-1.1	1.2	0.7	0.7	0.1	0.7	0.6	0.4	1.7	0.6	-1.2	-0.9	1.3
Pulse wave reflection index	0.5	0.6	2.0	-0.3	0.4	0.7	1.1	1.4	0.5	0.5	-1.1	1.1	0.5	-0.0	-0.2	0.5
Blood clot in the leg (DVT)	0.5	0.6	2.1	-0.2	0.3	0.8	0.2	0.8	0.8	0.9	-1.3	0.9	0.7	-0.0	-1.4	0.5
Pulse rate, automated reading	0.5	1.7	3.6	0.3	-0.6	-1.4	-1.7	-1.9	-1.3	-1.2	1.8	-1.6	-1.5	-0.4	1.0	-1.0
Comparative height size at age 10	0.5	2.8	5.6	0.2	-0.8	-2.1	-2.0	-1.5	-2.3	-2.3	-1.0	-0.0	-2.3	-1.1	2.4	-1.1
Age at last live birth	0.5	0.8	9.0	-0.1	0.0	0.2	0.1	0.4	0.1	0.6	-3.0	-0.0	-0.1	0.1	-0.5	0.2
Illnesses of siblings: Diabetes	0.5	0.6	3.1	-1.0	0.4	-0.5	-0.6	-0.6	-0.2	-0.6	-0.9	0.8	-0.4	-1.8	0.1	0.3
Wears glasses or contact lenses	0.5	0.6	2.9	-1.2	0.9	-0.1	-0.3	-0.3	-0.1	0.2	1.0	0.5	0.2	-1.7	0.3	0.9
Ever taken oral contraceptive pill	0.5	0.5	2.7	-0.8	0.7	-0.1	0.3	-0.3	-0.2	0.5	1.6	-0.2	0.2	-1.2	0.7	0.6
Number of operations (self-reported)	0.5	0.7	1.6	-0.5	0.5	1.1	0.9	1.0	1.0	1.0	-0.9	0.4	1.3	0.7	-0.6	0.7
Average weekly beer plus cider intake	0.5	0.7	6.1	-0.1	0.2	-0.5	-0.1	-0.1	-0.5	-0.1	2.5	1.1	-1.0	-0.5	-0.2	-0.2
Diastolic blood pressure, automated reading	0.5	1.5	4.4	1.7	-0.8	1.1	0.9	0.5	1.3	1.2	1.3	-1.4	0.8	2.1	-1.1	-0.7
Impedance of whole body	0.5	2.5	25.8	0.4	-0.4	0.5	0.5	0.5	0.2	-0.5	-5.1	-0.9	0.8	1.7	0.7	-0.2
Leg fat mass (left)	0.5	2.1	6.9	0.4	-0.8	-1.6	-1.7	-1.8	-1.5	-1.7	2.6	-0.3	-1.7	-0.7	0.6	-1.1
Bipolar Disorder (2018)	0.4	0.6	3.4	0.5	-0.5	-0.5	-0.5	-0.8	-0.6	-0.4	-1.8	0.7	-0.6	-0.0	0.7	-0.7
Neuroticism (2016)	0.4	0.6	3.0	0.4	-0.4	-0.5	-0.7	-0.7	-0.7	-0.1	1.1	1.7	-0.4	-0.2	0.6	-0.6
Triglycerides	0.4	0.7	1.8	0.1	-0.6	-1.1	-1.1	-0.4	-1.0	-0.9	1.4	-1.0	-0.9	-0.2	0.5	-0.7
Heel T-Score	0.4	3.6	11.3	3.4	-2.7	-1.1	-0.3	-2.0	-1.2	-1.4	-0.3	0.6	-1.6	3.2	0.6	-2.4
Hypothyroidism (self reported)	0.4	1.0	3.2	-0.2	-0.3	-1.3	-1.8	-1.1	-1.4	-0.8	0.1	-1.5	-1.2	-0.8	0.0	-0.5
Chronotype (morning person)	0.4	0.8	3.3	0.8	-0.9	-0.0	-0.2	0.0	0.4	-0.3	-1.6	-1.8	-0.1	1.5	0.6	-0.8
Relative age of first facial hair	0.4	0.8	2.5	-0.7	0.6	1.2	0.9	0.3	1.2	0.7	-0.1	-1.3	1.6	0.5	-0.5	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.0	0.9	-0.9	-0.5	-0.6	-0.7	-0.5	-0.4	1.4	-0.1	-0.5	0.6	0.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	1.2	-1.0	-0.5	-0.2	-1.0	-0.7	-0.1	0.6	0.1	-0.7	1.1	-0.3	-0.9
Fluid intelligence score	0.4	0.8	5.2	-0.4	0.6	0.7	0.5	0.8	0.6	1.1	2.3	0.8	0.7	0.4	-1.0	0.3
Neuroticism score	0.4	0.8	2.7	-0.7	1.0	0.9	0.6	0.7	0.8	1.2	0.9	0.3	0.6	-0.1	-1.7	0.9
Hip circumference	0.4	1.6	6.2	-0.2	-0.3	-1.4	-1.3	-1.5	-1.3	-1.3	2.5	-0.2	-1.4	-1.3	0.9	-0.6
Pulse rate	0.4	0.6	2.7	-0.8	0.6	-0.4	-0.7	-0.8	-0.3	-0.0	1.3	-1.6	-0.4	-0.9	0.7	0.1
Noisy workplace	0.4	0.5	1.1	0.3	-0.4	-1.0	-1.0	-0.2	-0.9	-0.7	0.5	0.7	-1.0	0.1	0.6	-0.6
Tense / ‘highly strung’	0.4	0.7	5.1	-0.2	0.4	0.4	0.5	0.2	0.1	1.1	2.3	0.3	0.3	0.3	-1.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	-0.3	0.5	0.8	0.5	0.7	0.9	0.9	0.4	-1.0	0.9	0.7	0.1	0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.8	-0.6	0.1	-0.5	-0.1	-0.5	-0.5	-0.5	-1.4	-0.6	-0.5	-0.6	1.3	0.0
Wheeze or whistling in the chest in last year	0.4	0.8	2.1	1.1	-1.2	-0.4	-0.8	-0.6	-0.3	-0.9	0.5	-1.5	-0.4	1.3	0.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.0	0.9	-0.7	-0.1	-0.5	-0.0	-0.0	0.6	-1.0	1.0	-0.2	0.6	-0.9	-0.6
Heart disease (mother)	0.4	0.5	3.2	0.9	-0.7	0.4	0.1	0.7	0.5	0.6	-0.7	-0.5	0.6	1.8	-0.2	-0.4
Number of full sisters	0.4	0.5	1.9	-0.1	0.6	-0.4	-0.1	-0.6	-0.3	-0.9	1.1	-1.4	-0.5	-0.2	0.8	0.3
Chest pain or discomfort	0.4	0.5	2.3	-0.2	0.5	1.0	1.5	0.5	0.8	0.2	-0.5	-0.2	1.0	0.2	-0.4	0.7
Knee pain experienced in last month	0.4	0.7	2.4	-0.9	0.9	0.8	0.5	0.4	1.0	0.9	0.1	1.1	0.4	-0.2	-1.6	0.8
Medication for cholesterol	0.4	0.6	1.4	-0.5	0.2	-0.5	-1.1	-0.6	-0.5	-0.8	-1.1	1.2	-0.9	-1.0	0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.4	-0.7	0.6	0.7	0.6	0.7	0.5	0.7	1.2	-0.0	0.4	-0.4	-0.6	0.7
Back pain experienced in last month	0.4	0.6	1.5	0.4	-0.8	-0.7	-0.7	-0.7	-0.7	-0.7	-0.7	-0.6	-0.9	0.6	1.2	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	-0.3	-0.1	-0.8	-1.0	-0.6	-0.8	-0.5	-1.1	0.7	-0.7	-0.8	0.3	-0.2
Average weekly champagne plus white wine intake	0.4	0.5	1.6	-0.7	0.8	0.7	0.4	0.9	0.5	1.3	0.8	0.2	0.8	-0.6	-0.1	0.8
Illnesses of father: High blood pressure	0.4	0.5	2.4	-0.7	0.9	0.5	1.0	0.5	0.5	0.4	1.6	-0.0	0.6	-0.6	-0.1	0.6
Basal metabolic rate	0.4	2.2	13.0	-0.5	0.3	-1.3	-1.2	-1.2	-1.4	-0.9	3.6	0.4	-1.7	-2.3	0.4	-0.2
Age started oral contraceptive pill	0.4	0.5	1.0	0.5	-0.1	0.9	0.6	0.5	0.9	0.9	-0.6	0.4	0.7	1.0	-0.9	0.2
Myopia	0.4	0.6	5.5	-0.1	-0.4	0.3	-0.1	0.4	0.2	0.0	-2.4	0.5	0.6	1.2	0.3	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.5	-0.9	1.0	1.3	1.5	1.6	1.1	0.6	-1.5	0.7	1.2	0.2	0.3	1.1
Cholesterol lowering medication	0.4	0.6	2.6	1.1	-0.5	0.5	0.4	0.6	0.5	1.2	0.5	-0.1	0.8	1.6	-0.5	-0.5
Supplements: Calcium	0.4	0.4	1.3	-0.9	0.7	0.5	0.4	0.1	0.6	0.3	0.2	-1.1	0.4	-0.8	-0.6	0.8
Heart disease (siblings)	0.4	0.5	1.8	1.3	-1.0	-0.2	-0.2	0.0	-0.2	0.1	-1.2	-0.2	-0.1	1.3	-0.3	-0.8
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.2	-1.1	0.9	0.5	0.3	0.9	0.5	1.1	1.8	1.2	0.4	-1.0	-1.0	0.7
Worry (Nagel 2018)	0.3	0.7	1.8	-0.5	0.7	0.8	0.4	0.7	0.7	0.9	1.4	-0.2	1.1	0.1	-1.2	0.7
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	0.4	-0.5	-0.4	-0.5	-1.0	-0.5	-0.4	0.6	1.1	-0.3	0.2	0.2	-0.6
Alzheimer’s Disease (in father)	0.3	0.3	0.8	-0.9	0.8	0.5	0.7	0.1	0.4	0.5	0.3	0.1	0.7	-0.8	-0.3	0.8
LDL Cholesterol	0.3	0.4	3.8	-0.6	0.3	0.1	0.1	0.4	0.2	0.4	1.9	0.6	-0.1	-0.5	-0.5	0.4
Primary Biliary Cirrhosis	0.3	0.4	2.0	0.6	-0.4	0.5	0.6	0.2	0.6	0.1	0.7	-0.3	0.3	1.4	-0.6	-0.2
BMI	0.3	1.7	15.0	0.4	-0.4	-0.9	-0.6	-1.1	-0.9	-1.2	3.9	-0.8	-0.9	-0.3	0.4	-0.7
Average weekly spirits intake	0.3	0.4	2.2	-0.4	0.1	-0.6	-0.8	-0.0	-0.5	0.0	1.5	0.6	-0.8	-0.5	0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.9	-0.6	0.3	-0.2	-0.7	-0.3	-0.0	-0.8	0.9	-0.9	-0.1	-0.8	-0.3	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	-0.6	0.6	0.7	0.8	0.5	0.9	0.2	0.2	-0.2	1.1	0.4	-0.2	0.7
Diabetes (father)	0.3	0.4	1.6	0.6	-0.1	0.7	0.4	0.7	0.7	0.9	-0.5	0.7	0.1	1.2	-0.6	-0.1
Sitting height	0.3	2.4	7.6	-2.6	2.3	0.7	0.9	0.7	0.1	0.6	-1.6	1.7	0.5	-2.8	0.1	1.9
Chronic bronchitis/emphysema (father)	0.3	0.4	4.3	0.1	-0.1	-0.2	-0.0	-0.2	0.1	-0.2	2.1	0.6	-0.2	-0.0	0.3	-0.0
Had menopause	0.3	0.4	1.2	-1.0	0.7	0.4	0.5	0.5	0.6	0.1	-0.6	0.2	0.4	-0.5	-1.1	0.8
Qualifications: None of the above	0.3	0.6	1.8	0.7	-1.1	-0.8	-0.7	-0.4	-0.4	-0.6	-0.7	1.3	-0.6	0.9	-0.3	-1.1
Impedance of arm (right)	0.3	1.4	14.7	-0.0	-0.2	-0.3	-0.2	0.1	-0.4	-0.7	-3.8	-0.8	0.0	0.5	1.1	-0.2
Trunk fat-free mass	0.3	1.8	9.5	-1.2	1.2	-0.3	-0.2	-0.2	-0.5	0.0	3.1	1.1	-0.8	-2.7	-0.5	0.9
Asthma	0.3	0.5	1.8	0.4	-0.5	-0.6	-1.1	-0.7	-0.6	-0.4	1.4	-0.6	-0.7	-0.1	0.9	-0.4
Medication: Cholesterol lowering	0.3	0.4	1.5	0.2	-0.8	-0.7	-0.9	-1.2	-0.6	-0.3	0.5	0.2	-0.7	0.1	0.0	-0.7
Trunk predicted mass	0.3	1.7	9.8	-1.1	1.1	-0.3	-0.3	-0.2	-0.5	-0.0	3.1	1.0	-0.8	-2.6	-0.4	0.8
High blood pressure (siblings)	0.3	0.4	2.2	0.6	-0.5	0.3	0.6	-0.2	0.3	0.3	0.4	-1.5	0.3	0.9	-0.8	-0.6
Leg fat percentage (right)	0.3	1.0	2.8	0.3	-0.6	-1.1	-1.2	-1.5	-1.0	-1.6	1.7	-0.3	-1.0	-0.3	0.4	-0.7
Worry too long after embarrassment	0.3	0.5	1.5	-1.1	1.2	0.4	0.3	0.4	0.3	-0.0	-1.1	-0.0	-0.1	-1.2	-0.6	1.0
Pulse wave peak to peak time	0.3	0.3	1.6	-0.3	0.2	-0.0	-0.2	-0.6	-0.0	-0.1	1.3	0.2	0.0	-0.8	-1.0	0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	-0.9	1.0	0.1	-0.3	0.4	-0.2	-0.1	0.8	-1.1	0.3	-0.7	1.1	0.8
Alcohol intake frequency.	0.3	0.6	4.4	-0.9	0.6	0.4	0.5	0.0	0.5	-0.1	-2.1	-0.2	1.0	-0.5	-0.1	0.4
Leg pain on walking	0.3	0.4	1.2	0.1	-0.2	-0.5	-0.7	-0.7	-0.6	-0.8	0.9	-1.1	-0.8	-0.2	0.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.3	0.7	-0.6	-0.4	-0.2	-0.5	-0.3	-0.6	-1.1	0.5	-0.3	0.5	0.2	-0.5
Hypertension (Self-reported)	0.3	0.8	2.0	1.0	-0.9	-0.9	-1.1	-1.2	-0.8	-0.1	1.4	-0.4	-0.8	0.2	-0.5	-1.0
Whole body fat-free mass	0.3	1.9	12.7	-0.7	0.6	-0.9	-0.8	-0.8	-1.0	-0.4	3.6	0.8	-1.4	-2.4	0.0	0.2
Mood swings	0.3	0.6	2.2	-0.2	0.4	0.4	0.3	0.4	0.6	0.9	0.9	1.4	0.1	-0.1	-1.5	0.5
Commuting to job workplace: Walk	0.3	0.4	1.1	0.4	-0.8	0.2	0.2	-0.3	0.2	0.4	-0.2	-0.9	0.3	1.1	1.0	-0.7
Mineral and other dietary supplements	0.3	0.4	1.0	0.8	-0.9	-0.6	0.0	-1.0	-0.6	-0.6	0.3	0.1	-0.8	0.6	0.1	-1.0
Osteoporosis (self-reported)	0.3	0.3	3.2	0.2	-0.5	-0.2	0.0	-0.1	-0.3	-0.4	-0.1	-1.8	-0.1	0.2	0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	3.8	-0.1	0.5	0.4	0.3	1.0	0.1	0.8	2.0	-0.0	0.3	-0.4	-0.8	0.5
Whole body water mass	0.3	1.9	12.2	-0.8	0.6	-0.9	-0.8	-0.8	-1.0	-0.4	3.5	0.7	-1.3	-2.4	0.0	0.2
Number of self-reported non-cancer illnesses	0.3	0.5	2.3	-0.0	-0.5	-0.7	-1.5	-0.8	-0.7	0.0	0.7	-0.1	-0.8	-0.7	0.6	-0.4
High cholesterol (Self-reported)	0.3	0.5	1.9	0.5	-0.1	0.9	0.5	0.7	0.8	1.4	0.2	-0.1	1.1	1.1	-0.3	0.1
Medication: Atorvastatin	0.3	0.3	2.0	0.5	-0.5	-0.2	0.0	-0.4	-0.4	-0.6	-0.4	-1.4	-0.4	0.5	0.2	-0.5
Arm fat-free mass (left)	0.3	1.4	9.1	-0.9	0.9	-0.4	-0.5	-0.4	-0.5	-0.2	3.0	0.8	-0.8	-2.1	-0.5	0.5
Ever depressed for a whole week	0.3	0.4	1.0	-0.9	0.8	0.1	0.6	-0.1	0.0	-0.3	1.0	0.4	0.3	-0.8	-0.2	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	2.5	0.1	-0.0	0.5	-0.1	0.7	0.5	0.6	-1.6	0.5	0.6	0.1	-1.0	0.1
Neuroticism (Nagel 2018)	0.2	0.5	1.4	-0.5	0.6	0.8	0.4	0.6	1.2	1.0	0.6	0.1	0.8	-0.1	-1.2	0.7
Crohns Disease (2017)	0.2	0.4	2.2	0.0	-0.5	-0.5	0.4	-0.5	-0.4	-0.5	-0.5	-1.5	-0.1	0.2	0.9	-0.5
Coronary Artery Disease (CAD)	0.2	0.3	1.3	0.9	-0.3	0.0	0.5	-0.2	0.0	0.4	0.2	-0.4	0.1	1.1	-0.8	-0.6
Rheumatoid Arthritis	0.2	0.2	0.6	-0.6	0.5	0.3	-0.2	0.8	0.3	0.4	-0.8	0.3	0.5	0.2	-0.3	0.4
Schizophrenia (2014)	0.2	0.5	3.4	-0.0	-0.0	-0.6	-0.3	-0.7	-0.6	-1.0	-1.9	-0.3	-0.7	-0.3	0.7	-0.3
Lung FEV1/FVC ratio	0.2	0.9	4.9	-0.1	-0.0	0.1	0.2	-0.5	0.3	0.1	2.2	-2.0	0.4	-0.2	1.4	-0.1
Lung FVC	0.2	1.1	7.8	-0.1	-0.1	-0.3	-0.0	0.1	-0.5	1.0	2.8	1.8	-0.6	-0.0	-1.2	-0.1
Neuroticism	0.2	0.5	1.1	-1.0	1.1	0.7	0.4	0.3	0.7	1.0	0.7	-0.1	0.7	-0.5	-0.6	0.9
Number of treatments/medications taken	0.2	0.3	1.1	-0.4	-0.0	-0.2	-0.1	-0.5	-0.1	0.3	0.8	-1.1	-0.1	-0.9	-0.8	0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.4	-0.6	0.5	0.2	0.3	0.0	0.2	0.5	1.2	0.4	0.2	-0.6	0.0	0.5
High blood pressure	0.2	0.5	1.3	0.7	-0.6	-0.7	-0.8	-1.0	-0.6	0.0	1.1	-0.3	-0.6	-0.1	-0.6	-0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	4.5	-0.1	0.3	0.4	0.7	0.3	0.4	0.4	2.1	-0.3	0.5	-0.1	-0.7	0.4
Medication: Levothyroxine sodium	0.2	0.3	1.4	0.4	-0.6	-0.4	-1.2	-0.0	-0.4	-0.0	-0.5	-1.0	-0.5	0.2	-0.3	-0.5
Nervous feelings	0.2	0.3	1.7	0.4	-0.5	-0.3	-0.6	-0.3	-0.5	-0.4	0.7	-1.3	0.0	0.7	-0.0	-0.6
Hearing difficulty/problems with background noise	0.2	0.3	1.4	-0.4	-0.3	-0.4	-0.4	-0.4	-0.3	-0.2	0.8	-1.1	-0.1	0.1	1.2	-0.1
Had other major operations	0.2	0.2	2.4	-0.0	-0.1	0.2	0.2	0.0	0.3	-0.1	0.4	-1.5	-0.0	-0.0	-0.0	0.2
Mouth/teeth dental problems	0.2	0.4	1.0	-0.6	0.6	0.5	0.6	0.5	0.3	0.5	0.7	1.0	0.4	-0.9	-0.3	0.8
Allergy	0.2	0.6	4.3	-0.5	0.4	0.6	0.7	0.3	0.6	0.3	-2.1	0.8	0.7	-0.0	0.0	0.4
Medication: Simvastatin	0.2	0.3	1.5	0.5	-0.3	0.5	0.1	0.0	0.6	1.2	-0.1	-0.1	0.8	1.1	-0.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.3	0.2	-0.3	-0.3	-0.9	-0.4	-0.4	-0.8	0.7	-0.2	-0.9	0.1	0.1
Pulse wave Arterial Stiffness index	0.2	0.2	1.3	0.1	-0.1	0.0	0.2	0.5	0.0	0.2	-1.2	-0.1	-0.0	0.6	1.0	-0.2
Breastfed as a baby	0.2	0.2	1.5	-0.4	-0.0	-0.0	-0.3	0.8	-0.3	0.2	1.2	0.1	-0.5	-0.0	-0.3	-0.1
Headache pain in last month	0.2	0.3	1.2	-0.3	0.4	0.5	1.1	0.3	0.6	0.6	-0.2	0.4	0.9	0.1	-0.5	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	-0.9	0.5	-0.1	-0.8	0.2	-0.1	0.4	-0.0	-1.1	-0.2	-1.0	-0.9	0.5
Arm fat-free mass (right)	0.2	1.1	8.0	-0.2	0.2	-0.7	-0.7	-0.7	-0.8	-0.4	2.8	0.7	-1.0	-1.5	-0.2	-0.1
Age at first live birth	0.2	0.4	2.7	0.6	-0.7	0.1	0.0	0.4	-0.2	0.5	-1.6	-0.6	0.1	0.6	0.2	-0.5
Health satisfaction	0.2	0.3	1.3	-0.2	0.4	0.6	0.8	0.3	0.5	0.1	0.9	-1.2	0.0	-0.1	-0.2	0.5
Shortness of breath walking on level ground	0.2	0.3	1.1	-0.5	0.3	-0.3	0.0	-0.7	-0.4	-0.7	0.0	-0.6	-0.3	-1.1	0.3	0.4
Eye problems/disorders: None of the above	0.2	0.2	1.9	-0.4	0.4	0.0	0.4	-0.2	0.1	-0.2	-1.4	0.4	0.1	-0.1	0.0	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.5	0.8	-0.5	0.2	0.1	0.4	0.2	0.3	0.8	-0.4	0.3	1.2	0.2	-0.4
Medication: Omeprazole	0.2	0.3	0.6	0.6	-0.6	-0.4	-0.3	-0.7	-0.2	-0.3	-0.7	-0.1	-0.5	0.8	0.6	-0.6
Arm predicted mass (right)	0.2	1.3	11.0	-0.3	0.3	-0.6	-0.5	-0.6	-0.7	-0.4	3.3	0.7	-0.9	-1.6	-0.2	-0.0
Overall health rating	0.2	0.4	2.1	-0.4	0.1	-0.1	0.1	-0.3	-0.1	-0.5	1.4	-1.1	-0.3	-0.8	0.4	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	-0.3	0.2	0.3	0.5	0.6	0.5	0.1	-0.8	-0.6	0.7	-0.3	-0.1	0.4
Illnesses of father: Heart disease	0.2	0.3	1.3	1.0	-0.9	0.1	0.1	-0.6	0.1	-0.2	-0.5	-0.3	0.1	1.1	-0.3	-0.6
Smoking status: Previous	0.2	0.3	1.3	-0.9	0.5	-0.2	-0.8	-0.4	0.0	-0.1	-1.1	-0.0	-0.1	-0.9	0.5	0.1
Ever had bowel cancer screening	0.2	0.2	1.2	-0.3	-0.1	-0.1	-0.2	0.3	0.3	-0.0	-1.1	0.9	0.1	0.2	0.5	0.0
Eye problems/disorders: Cataract	0.2	0.3	2.4	-0.3	-0.3	0.0	-0.2	0.4	-0.2	0.2	1.5	-0.4	-0.1	-0.4	0.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	2.2	-0.2	0.3	0.3	0.6	-0.2	0.3	-0.4	-0.4	-1.5	0.6	0.0	0.1	0.1
Asthma (self-reported)	0.2	0.4	1.2	0.4	-0.5	-0.4	-0.8	-0.6	-0.4	-0.2	1.1	-0.8	-0.5	-0.0	0.7	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	0.3	-0.5	-0.6	-0.5	-0.7	-0.6	-0.2	0.3	0.9	-0.5	-0.3	0.0	-0.6
Commuting to job workplace: Public transport	0.2	0.2	1.0	-0.2	0.2	0.6	0.3	-0.2	0.7	0.5	1.0	-0.3	0.5	0.4	-0.2	0.3
Medication: Bendroflumethiazide	0.2	0.3	0.8	-0.3	-0.0	-0.7	-0.5	-0.7	-0.6	-0.5	0.2	-0.1	-0.8	-0.9	-0.4	-0.1
Leg fat percentage (left)	0.2	0.7	3.2	0.2	-0.4	-0.8	-0.9	-1.2	-0.6	-1.1	1.8	0.0	-0.7	-0.3	0.1	-0.5
Pain experienced in last month	0.2	0.4	2.5	0.9	-0.5	-0.2	0.2	0.3	-0.5	-0.2	1.6	-0.7	-0.2	0.4	0.0	-0.4
Arm predicted mass (left)	0.2	1.3	8.1	-1.0	1.0	-0.2	-0.2	-0.1	-0.2	0.1	2.9	0.9	-0.6	-2.0	-0.7	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	-0.1	0.4	0.3	0.3	-0.1	0.5	0.7	0.6	0.3	0.3	-0.0	-0.6	0.2
Body Mass Index (BMI) (2010)	0.1	0.1	0.5	0.5	-0.2	-0.0	0.3	0.2	-0.1	0.3	0.7	0.2	0.2	0.5	-0.4	-0.2
Crohns Disease (2012)	0.1	0.1	0.5	-0.6	0.3	-0.3	0.2	0.1	0.0	-0.3	0.1	0.2	-0.0	-0.7	0.3	0.2
HDL Cholesterol	0.1	0.2	0.6	-0.6	0.7	0.3	-0.2	-0.4	0.6	0.5	-0.4	0.2	0.0	-0.4	0.1	0.8
Blood Eosinophil Count	0.1	0.9	3.7	-0.1	0.3	0.7	0.9	1.4	1.0	0.3	1.9	0.6	1.2	0.0	-1.1	0.5
Height	0.1	2.2	5.2	0.7	-0.8	-1.8	-1.4	-2.3	-2.2	-1.9	-0.6	0.3	-2.0	-1.0	1.5	-1.2
Systolic Blood Pressure	0.1	0.7	3.5	1.2	-0.5	0.4	0.5	0.3	0.6	0.6	0.6	-1.9	0.2	1.5	-0.2	-0.4
Allergy or Eczema	0.1	0.1	1.1	0.0	0.1	-0.2	0.2	0.1	-0.2	-0.3	1.1	-0.2	-0.1	-0.3	-0.5	0.1
Hair Pigment	0.1	2.7	6.0	-2.3	2.4	1.8	1.3	1.7	1.6	1.0	1.0	-1.1	1.8	-1.3	-0.6	2.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.9	0.2	-0.2	-0.3	-0.2	-0.7	-0.5	-0.1	1.0	-0.3	-0.6	0.1	0.1	-0.3
Systolic blood pressure, automated reading	0.1	0.4	0.9	0.8	-0.3	0.6	0.4	0.4	0.9	1.0	0.6	-0.0	0.5	0.7	-0.9	-0.2
Severe depression (siblings)	0.1	0.1	0.5	-0.5	0.1	0.1	-0.1	-0.5	0.1	-0.4	-0.3	-0.6	-0.3	-0.0	0.7	0.2
Fed-up feelings	0.1	0.3	1.2	0.2	0.0	-0.2	-0.5	-0.9	-0.3	-0.0	1.1	0.4	-0.6	-0.2	-0.8	-0.1
Forced vital capacity (FVC)	0.1	0.4	1.9	0.2	-0.1	-0.8	-0.8	-0.2	-1.4	-0.4	0.7	0.2	-1.1	-0.6	0.4	-0.4
Illnesses of siblings	0.1	0.2	0.6	0.2	-0.1	-0.3	-0.3	-0.0	-0.5	-0.4	-0.6	0.6	-0.4	0.3	0.8	-0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.8	0.2	-0.0	-0.4	-0.4	-0.5	-0.3	-0.9	-0.6	0.4	-0.2	-0.0	0.7	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.5	-0.2	0.3	-0.3	0.0	0.1	-0.8	0.1	1.2	-0.4	-0.5	-0.7	0.5	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.9	-0.2	0.3	-0.2	-0.2	0.1	-0.8	0.1	1.4	-0.3	-0.3	-0.7	0.1	0.0
Standing height	0.1	0.9	3.4	-0.9	0.5	-0.8	-0.6	-0.4	-1.3	-1.0	-0.9	0.6	-1.1	-1.9	1.1	0.1
Length of working week for main job	0.1	0.1	0.7	-0.0	0.2	0.1	-0.1	0.5	0.2	0.0	-0.6	-0.9	0.2	0.3	-0.4	0.1
Peak expiratory flow (PEF)	0.1	0.2	1.3	0.1	0.3	0.2	0.3	0.6	0.1	0.5	1.1	-0.1	0.2	0.0	0.1	0.2
Birth weight	0.1	0.2	0.7	0.7	-0.2	-0.1	0.0	-0.3	-0.2	-0.6	-0.2	0.2	-0.5	0.2	0.8	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.3	1.6	0.2	-0.0	-0.5	-0.5	-0.1	-1.2	-0.3	1.2	-0.2	-0.7	-0.4	0.0	-0.3
Qualifications: College or University degree	0.1	0.2	1.2	0.2	0.2	0.0	0.1	-0.2	-0.2	-0.2	0.7	-1.1	-0.4	0.0	0.8	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.5	0.1	0.2	0.4	-0.3	0.3	0.7	0.5	-0.1	-0.3	0.4	0.2	-0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.6	0.4	0.4	0.4	0.3	0.2	0.0	0.1	-0.3	0.4	-0.2	-0.1	-0.8	0.3
Long-standing illness, disability or infirmity	0.1	0.2	0.8	0.0	-0.1	-0.2	-0.6	-0.9	-0.0	-0.5	-0.1	-0.2	-0.5	-0.3	-0.7	0.2
Miserableness	0.1	0.2	1.1	-0.6	0.5	-0.3	-0.3	-0.3	-0.3	0.1	0.3	0.6	-0.4	-1.1	-0.6	0.2
Medication: Blood pressure	0.1	0.3	1.5	-0.0	0.2	0.2	0.5	0.1	0.2	0.6	1.2	-0.8	0.5	0.3	-0.4	0.0
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.7	0.4	0.2	0.5	-0.4	-0.0	-0.4	-0.4	0.3	-0.0	-0.6	-0.2	0.5
Commuting to job workplace: Cycle	0.1	0.2	0.8	-0.1	-0.0	0.5	0.6	0.4	0.5	0.0	0.5	0.2	-0.0	0.3	-0.9	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.8	0.3	-0.0	0.4	0.6	0.1	0.5	0.1	-0.9	-0.1	0.2	0.6	0.3	0.1
Blood Platelet Count	0.0	0.4	1.7	0.7	-1.0	-0.1	-0.6	-0.5	-0.0	0.2	-0.6	0.4	-0.5	1.3	-0.1	-0.8
Tanning	0.0	0.5	2.0	1.4	-0.9	-0.4	0.1	-0.5	-0.3	-0.3	0.4	0.7	-0.6	1.2	-0.3	-0.9
Maternal smoking around birth	0.0	0.0	0.1	-0.0	0.1	-0.3	-0.1	-0.2	-0.3	-0.3	0.2	-0.1	-0.1	-0.1	0.4	-0.0
Neck or shoulder pain in last month	0.0	0.1	0.4	-0.6	0.2	0.1	0.0	-0.3	0.4	0.2	0.0	-0.3	0.1	0.0	0.1	0.3

Hub : Genes

ATF7IP2

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Trait associations