Hub : Genes

ATP2B4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1640	0.0480	7.3e-04	-0.003	NA	-0.002	NA	-0.003	7.9e-01	NA	5.5e-01	NA	8.1e-01
2	METSIM	Adipose	0.0879	0.0262	1.3e-04	0.070	0.036	0.084	0.059	0.089	9.9e-11	3.3e-06	1.5e-12	3.5e-09	3.0e-13
3	YFS	Blood	0.1305	0.0252	1.6e-13	0.079	0.045	0.059	0.072	0.079	1.0e-24	1.7e-14	8.8e-19	1.9e-22	1.0e-24

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.2	0.0	0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.1	0.0	0.7
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	1.3	0.7	-0.6
Depression (Nagel 2018)	1.0	1.5	2.3	1.4	1.5	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	-0.8	-0.1	-1.0
Neuroticism (Nagel 2018)	0.4	0.9	2.0	1.4	0.5	-0.7
Schizophrenia (2018)	0.0	0.1	0.2	0.1	0.0	0.5
Schizophrenia vs Biploar Disorder	0.5	0.7	2.1	-1.5	0.0	-0.1
Worry (Nagel 2018)	0.1	0.3	0.5	0.7	0.5	0.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.5	0.0	0.4
Alzheimer’s Disease (in father)	1.0	1.1	1.8	-1.4	0.9	0.8
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	-1.0	0.6	0.5
Crohns Disease (2017)	0.5	1.1	2.0	1.4	-0.8	0.8
Irritable Bowel Disease (IBD)	1.0	2.3	5.0	2.2	-1.4	-0.1
Ulcerative Colitis (UC)	1.1	2.0	4.0	2.0	-1.2	-0.8
Major Depression (MDD)	0.3	0.4	0.6	0.3	0.6	-0.8
Reaction Time	0.3	0.6	1.2	-0.8	-0.1	1.1
Verbal and Numeric Reasoning (VNR)	0.7	1.8	4.8	-0.1	-0.7	-2.2
Breast Cancer	1.2	3.0	4.3	1.1	-2.1	-1.9
Ovarian Cancer	2.1	2.8	4.9	-1.7	-0.8	2.2
Prostate Cancer	0.4	0.6	1.0	0.1	0.8	1.0
Age at First Birth	0.9	1.4	4.1	-0.0	-0.1	2.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.2	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.2	0.0	0.8
Coronary Artery Disease (CAD)	0.3	0.3	1.0	1.0	0.0	-0.0
Crohns Disease (2012)	0.6	1.0	2.8	1.7	0.0	0.4
Mean Putamen Volume	1.4	1.6	2.7	-1.4	0.0	1.6
Fasting Glucose	0.9	1.1	1.9	-0.5	-1.0	-1.4
HbA1C	1.7	1.8	3.5	-1.9	-1.4	0.3
HDL Cholesterol	0.2	0.4	0.9	-0.6	0.0	0.9
LDL Cholesterol	0.1	0.1	0.4	0.2	0.0	0.6
Lupus	0.3	0.4	1.1	-1.1	-0.3	0.1
Neuroticism (2016)	0.4	0.6	0.9	0.9	0.9	0.3
Primary Biliary Cirrhosis	1.0	1.4	3.6	1.9	0.0	-0.7
Rheumatoid Arthritis	0.2	0.3	0.6	0.5	0.0	0.8
Schizophrenia (2014)	0.1	0.3	0.7	-0.5	0.0	0.8
Triglycerides	0.1	0.2	0.7	0.8	0.0	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.1	1.0	0.0	0.4
Ulcerative Colitis	0.7	1.1	3.2	1.8	0.0	0.1
Blood Eosinophil Count	0.2	1.3	3.6	-1.9	0.4	-0.5
Blood Platelet Count	0.4	4.2	10.3	-1.1	0.9	3.2
Blood Red Count	0.5	4.5	11.2	1.1	-1.0	3.4
Blood White Count	0.2	1.3	3.1	1.8	0.7	0.5
Heel T-Score	0.3	2.3	6.6	-0.1	-0.7	-2.6
BMI	1.2	7.2	20.2	-1.2	4.5	-0.2
Height	0.6	11.2	30.6	-1.4	1.0	5.5
Waist Hip Ratio (WHR)	2.0	9.1	24.5	-1.2	-5.0	1.1
Systolic Blood Pressure	1.4	7.1	9.5	-1.9	-3.1	-2.8
Smoking Status	0.8	1.9	4.2	-1.2	0.3	-2.0
Allergy or Eczema	0.7	1.8	2.8	0.5	1.6	-1.7
Cardiovascular Disease	1.9	6.1	15.7	-1.4	-0.8	-4.0
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.5	0.8	0.2
Respiratory disease	0.1	0.3	0.5	-0.2	-0.7	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	-0.5	0.4	-0.6
Lung FEV1/FVC ratio	0.3	1.6	4.7	0.3	-0.2	-2.2
Lung FVC	0.1	0.7	1.8	0.5	1.3	0.4
Neuroticism	0.6	1.5	2.5	1.2	-1.6	-0.7
Chronotype (morning person)	0.9	2.1	4.5	0.7	-2.1	1.1
Hair Pigment	0.1	2.3	5.1	0.3	-2.2	1.3
Tanning	0.3	3.3	4.8	2.2	1.2	-1.9
Hand grip strength (left)	0.1	0.4	0.6	-0.8	0.7	0.1
Number of treatments/medications taken	1.8	3.2	7.4	1.2	-0.8	-2.7
Average weekly spirits intake	0.7	0.8	1.0	-0.9	0.8	-1.0
Sensitivity / hurt feelings	0.3	0.5	0.9	0.3	-0.9	0.7
Frequency of depressed mood in last 2 weeks	1.2	1.7	2.5	1.6	0.7	1.5
Hearing difficulty/problems: Yes	0.1	0.2	0.4	0.5	0.6	-0.0
Relative age of first facial hair	0.8	1.7	2.6	1.3	-1.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	0.6	-0.3	1.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.9	-1.7	0.7	-0.3
Ever had hysterectomy (womb removed)	0.5	0.6	0.7	-0.6	0.8	0.8
Systolic blood pressure, automated reading	1.0	2.8	5.1	-1.2	-2.3	-1.4
Eye problems/disorders: Diabetes related eye disease	3.4	3.7	6.5	-2.1	0.3	-2.5
Angina	0.2	0.3	0.6	0.6	0.8	-0.1
Medication for hormone replacement therapy	0.5	0.6	1.4	-0.0	0.5	-1.2
Vitamin and mineral supplements	0.2	0.3	0.6	0.5	-0.7	-0.2
Supplements: Zinc	1.6	1.7	2.8	1.7	-1.3	-0.8
Medication: Co-codamol	0.3	0.3	0.8	0.9	0.1	-0.2
Medication: Metformin	0.4	0.6	1.7	0.1	-1.3	0.2
Diabetes (father)	0.9	1.2	3.1	-0.1	0.6	1.8
Diabetes (mother)	0.8	1.1	2.6	-0.6	-1.6	0.5
Severe depression (siblings)	0.1	0.1	0.3	-0.4	-0.5	-0.0
Pack years adult smoking proportion	0.2	0.3	0.7	-0.1	0.3	-0.8
Impedance of leg (right)	0.9	4.2	10.8	0.4	1.3	-3.3
Leg fat-free mass (left)	0.8	4.3	7.2	-1.6	1.8	2.7
Trunk fat percentage	3.3	13.2	30.7	-1.8	5.5	-2.3
Hand grip strength (right)	0.3	0.8	1.5	-0.9	1.2	-0.1
Townsend deprivation index at recruitment	1.3	1.8	4.7	0.7	-2.2	0.5
Current tobacco smoking	0.2	0.3	0.6	-0.6	0.8	-0.0
Average weekly fortified wine intake	1.1	1.3	2.3	0.8	1.5	-0.9
Maternal smoking around birth	1.7	2.4	3.0	-1.7	1.7	-1.2
Fed-up feelings	0.0	0.1	0.1	-0.2	0.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	0.0	0.8	-0.0
Relative age voice broke	2.6	3.9	8.7	0.4	-2.9	-1.7
Taking other prescription medications	0.5	0.8	1.3	1.1	-0.3	-1.0
Age when periods started (menarche)	0.5	1.3	2.6	0.9	0.7	1.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	3.2	-0.5	0.6	1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	10.1	-2.3	0.4	-3.2
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.7	-0.4	-1.9	1.2
Qualifications: CSEs or equivalent	1.1	1.5	2.5	-0.6	1.6	-1.3
Serious illness, injury or assault to yourself	0.6	0.7	1.0	1.0	-0.9	-0.7
High blood pressure	1.8	5.0	14.7	-0.3	-0.5	-3.8
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.8	0.3	1.0	-1.7
Multivitamins +/- minerals	0.4	0.5	0.8	-0.8	0.2	-0.9
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.8	0.5	0.1
Supplements: Glucosamine	0.6	0.8	0.8	0.9	0.9	0.9
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	5.7	0.9	-1.6	-2.4
Medication: Atenolol	3.3	4.1	10.8	-0.3	-1.2	-3.3
Medication: Levothyroxine sodium	0.7	1.3	2.1	1.3	0.2	1.5
Sitting height	0.7	4.9	13.3	-0.8	-0.9	3.6
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	0.3	-0.6	-0.2
High blood pressure (mother)	0.0	0.0	0.1	-0.1	-0.4	-0.1
Body mass index (BMI)	1.3	5.4	12.0	-2.0	3.5	-0.6
Impedance of leg (left)	0.8	4.0	10.3	0.7	1.1	-3.2
Leg predicted mass (left)	0.9	4.6	7.9	-1.6	1.8	2.8
Trunk fat mass	2.4	10.2	25.9	-1.8	5.1	-1.1
Waist circumference	1.8	6.7	16.2	-2.0	4.0	0.1
Number of incorrect matches in round	0.3	0.5	1.2	1.1	-0.3	0.2
Past tobacco smoking	0.1	0.2	0.2	-0.3	0.4	0.5
Alcohol usually taken with meals	0.3	0.5	1.5	-0.1	0.1	-1.2
Nervous feelings	0.1	0.3	0.5	0.6	-0.7	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.0	0.9	1.0	-0.2
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.9	-0.0	-0.4
Hair/balding pattern: Pattern 2	0.5	0.7	1.7	0.1	-1.3	-0.5
Had menopause	0.1	0.1	0.3	-0.2	0.5	-0.0
Had other major operations	0.5	0.6	1.4	-0.7	0.1	1.2
Forced vital capacity (FVC)	0.3	1.1	2.3	0.5	0.8	1.5
Heel bone mineral density (BMD) T-score, automated (right)	2.1	4.7	11.2	-1.6	0.5	-3.3
Ever unenthusiastic/disinterested for a whole week	1.8	2.1	3.3	0.9	-1.5	-1.8
Qualifications: None of the above	0.3	0.6	1.2	0.4	-1.1	0.6
Financial difficulties in last 2 years	0.7	1.0	2.0	0.9	-0.5	1.4
Mouth/teeth dental problems	0.6	0.9	2.2	-0.1	1.5	-0.6
Heart attack	0.1	0.1	0.2	0.4	0.3	-0.2
Allergy	0.7	1.7	5.1	0.2	0.1	2.2
Pain all over the body in last month	0.4	0.4	1.0	0.1	-1.0	0.4
Diabetes (self-reported)	0.3	0.5	1.0	-0.3	-1.0	-0.4
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.9	-0.0	-0.1	-1.4
Medication: Ramipril	0.4	0.5	0.8	-0.4	-0.9	-0.7
Medication: Simvastatin	1.1	1.6	2.4	1.6	-0.9	-1.2
Fluid intelligence score	0.9	1.9	5.1	0.8	0.2	-2.3
Illnesses of siblings	0.6	0.8	1.4	1.2	1.1	-0.1
Neuroticism score	0.5	1.1	2.3	1.5	-0.7	-0.7
Weight	1.2	6.0	11.7	-2.3	3.4	1.0
Impedance of arm (right)	1.3	6.2	10.0	1.1	2.7	-3.2
Arm fat percentage (right)	2.2	8.8	19.0	-1.5	4.4	-2.3
Trunk fat-free mass	0.8	4.8	12.7	-1.4	-0.1	3.6
Hip circumference	3.7	16.0	44.2	-1.9	6.7	-0.4
Time employed in main current job	0.0	0.0	0.1	0.2	0.1	-0.2
Alcohol intake versus 10 years previously	0.5	0.7	1.6	-0.4	1.2	0.6
Father’s age at death	0.2	0.3	0.6	0.8	-0.3	-0.2
Worrier / anxious feelings	0.3	0.6	1.0	1.0	0.5	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.5	0.1	-0.6
Falls in the last year	0.4	0.6	1.2	1.1	-0.5	0.6
Hair/balding pattern: Pattern 3	0.7	1.1	1.6	-1.2	0.1	1.3
Number of live births	0.4	0.6	1.2	-0.6	1.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.5	0.5	1.2	1.2
Pulse rate	1.0	1.7	4.0	2.0	1.0	-0.2
Happiness	1.1	1.3	3.1	1.8	0.8	0.5
Noisy workplace	0.2	0.3	0.4	-0.4	0.5	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.5	-0.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.6	-1.6	-0.2	0.0
Mouth/teeth dental problems: Dentures	0.8	1.4	3.2	-1.8	0.3	0.9
Asthma	0.9	1.8	3.5	-0.9	-1.1	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.7	0.0	-0.1	-1.3
Medication: Cholesterol lowering	1.2	1.8	4.0	2.0	-1.0	-0.7
Depression (self-reported)	1.2	1.4	3.6	0.3	1.9	-0.8
Medication: Lansoprazole	0.2	0.3	0.4	0.2	0.6	-0.6
Prospective memory result	2.2	2.7	4.3	2.1	-1.0	1.6
Lung cancer (father)	0.7	0.8	1.1	1.0	1.0	0.6
Illnesses of mother	0.0	0.1	0.1	0.2	0.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.2	0.7	1.5	0.9
Pulse wave Arterial Stiffness index	2.9	3.4	8.6	0.2	-1.2	2.9
Impedance of arm (left)	1.4	6.4	11.2	0.8	2.7	-3.3
Arm fat mass (right)	1.3	5.6	12.7	-1.7	3.6	-1.0
Trunk predicted mass	0.8	4.7	12.5	-1.3	-0.1	3.5
Standing height	0.5	4.8	14.0	-0.6	0.4	3.7
Length of working week for main job	0.6	0.6	1.3	-0.2	-0.7	-1.1
Exposure to tobacco smoke at home	0.7	0.8	1.9	0.8	1.4	0.0
Breastfed as a baby	0.6	0.7	1.8	0.1	-0.5	1.4
Tense / ‘highly strung’	3.1	5.2	11.6	3.4	-0.5	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	4.6	1.8	2.1	-0.2
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	-1.1	-0.0	0.7
Birth weight of first child	0.3	0.5	1.2	0.4	1.1	0.1
Peak expiratory flow (PEF)	0.5	1.1	3.3	-0.3	1.8	0.1
Pulse wave reflection index	1.7	2.1	4.1	0.5	-1.4	2.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	-0.2	0.2	-1.0
Loud music exposure frequency	0.4	0.4	0.9	0.4	-0.3	-1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.2	0.2	1.5	-0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	-0.3	-1.1	-1.0
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.9	0.3	0.5
Medication: Paracetamol	0.9	1.4	3.5	0.7	-0.5	-1.9
Headache pain in last month	0.5	0.8	2.1	0.3	1.4	-0.5
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	4.6	-2.0	-0.5	2.1
Glaucoma (self-reported)	1.1	1.3	2.7	1.1	0.2	1.6
Gout (self-reported)	0.6	0.9	2.5	-0.0	1.6	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.5	0.1	1.2	1.0
Medication: Amlodipine	0.5	0.6	1.8	0.4	-0.1	-1.3
Medication: Ventolin 100micrograms inhaler	1.2	1.6	3.2	-0.8	-1.8	0.9
Birth weight	1.1	2.3	5.3	-0.8	2.3	1.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.2	1.5	0.8	0.2
High blood pressure (siblings)	0.4	0.6	0.7	-0.8	-0.7	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.4	1.9	0.7	1.3	1.4
Body fat percentage	3.1	12.3	27.5	-2.0	5.2	-2.4
Leg fat percentage (right)	2.9	10.4	21.5	-2.0	4.6	-2.4
Arm fat-free mass (right)	0.9	4.4	10.5	-1.6	0.2	3.2
Exposure to tobacco smoke outside home	0.3	0.4	0.7	0.7	-0.8	-0.3
Comparative body size at age 10	2.1	5.9	9.1	-3.0	0.6	2.9
Number of full brothers	0.7	0.9	1.5	-0.0	1.2	1.1
Worry too long after embarrassment	0.5	0.8	1.8	0.7	-0.2	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.2	2.3	-0.2	1.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	0.1	-0.4	-1.4
Number of children fathered	0.4	0.5	1.1	-1.0	0.4	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.4	0.3	1.2	-0.0
Age at first live birth	0.3	0.5	1.0	-0.7	-1.0	-0.1
Pulse wave peak to peak time	2.2	2.6	6.4	-0.5	1.2	-2.5
Health satisfaction	1.4	1.9	5.3	-0.4	2.3	0.3
Shortness of breath walking on level ground	0.3	0.3	0.9	-0.2	1.0	-0.2
Qualifications: College or University degree	1.0	3.3	4.6	-1.7	1.5	-2.1
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.2	0.2	0.3
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.7	-0.6	1.6	-0.3
Emphysema/chronic bronchitis	0.0	0.0	0.1	-0.3	0.0	-0.2
Medication for pain relief, constipation, heartburn	0.8	1.3	2.3	-0.3	1.2	1.5
Neck or shoulder pain in last month	0.2	0.2	0.6	0.1	0.2	-0.8
Medication: Blood pressure	2.2	3.8	6.9	1.9	1.0	-2.6
Angina (self-reported)	0.4	0.6	1.1	0.7	1.0	-0.3
Migraine (self-reported)	0.7	0.8	2.2	-0.6	1.5	0.1
Medication: Ibuprofen	1.2	1.4	4.2	0.3	0.1	-2.0
Medication: Allopurinol	0.8	1.0	1.6	-0.8	0.9	-1.3
Medication: Omeprazole	0.1	0.1	0.2	0.5	0.3	-0.1
Medication: Seretide 50 evohaler	0.7	0.8	2.2	-1.5	0.3	0.0
Mean time to correctly identify matches	0.8	1.5	2.6	-1.3	-0.0	1.6
Heart disease (mother)	0.9	1.1	2.7	-0.8	0.2	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.1	3.9	1.5	-0.2	-2.0
Whole body fat mass	2.1	8.9	22.6	-1.8	4.8	-1.0
Leg fat mass (right)	1.9	7.5	18.7	-1.8	4.3	-0.7
Arm predicted mass (right)	0.8	4.2	9.9	-1.6	0.3	3.1
Pulse rate, automated reading	0.9	2.8	7.8	2.8	0.5	0.4
Alcohol intake frequency.	0.1	0.3	0.7	0.9	-0.5	0.0
Comparative height size at age 10	0.5	2.5	2.9	-1.7	1.5	1.5
Number of full sisters	0.3	0.4	1.1	-0.4	-1.0	-0.1
Suffer from ‘nerves’	0.8	1.3	2.3	1.5	-1.0	-0.7
Overall health rating	0.1	0.2	0.3	-0.4	-0.1	-0.5
Chest pain or discomfort	1.5	2.2	3.8	1.1	1.2	-1.9
Had major operations	1.2	1.4	2.4	-0.8	1.5	1.1
Age at last live birth	1.1	1.6	4.4	0.7	-2.1	-0.0
Family relationship satisfaction	0.4	0.5	1.3	0.1	-1.1	-0.4
Leg pain on walking	0.8	1.0	1.6	-1.3	1.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	0.8	-0.1	1.3
Commuting to job workplace: Car/motor vehicle	2.2	2.6	7.7	0.1	-0.2	-2.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	0.4	0.4	-1.1
Medication: Aspirin	0.2	0.3	0.4	0.1	-0.6	-0.7
Supplements: Vitamin C	0.1	0.1	0.2	-0.2	-0.4	-0.4
Knee pain experienced in last month	0.8	1.3	3.5	0.6	1.9	0.1
Hypertension (Self-reported)	2.0	5.5	16.1	0.1	-0.6	-4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	3.6	-0.8	-1.2	-1.9
Illnesses of father: Heart disease	0.9	1.2	2.0	-1.4	1.2	0.1
Illnesses of siblings: Diabetes	0.6	0.8	1.2	-0.9	-0.6	-1.1
Smoking status: Previous	0.1	0.1	0.2	-0.2	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.8	0.6	1.1	1.3
Whole body fat-free mass	0.9	5.1	12.4	-1.6	0.5	3.5
Leg fat-free mass (right)	1.0	5.2	11.6	-1.4	1.4	3.4
Arm fat percentage (left)	2.4	9.5	19.6	-1.7	4.4	-2.5
Average weekly red wine intake	0.6	0.8	1.5	-1.2	-0.8	0.5
Handedness (chirality/laterality): Left-handed	1.1	1.4	2.4	1.6	-0.7	-1.1
Mood swings	0.8	1.5	2.2	1.5	0.9	-1.2
Loneliness, isolation	0.1	0.2	0.3	0.3	0.4	0.6
Long-standing illness, disability or infirmity	0.8	1.3	2.5	1.6	0.6	-1.0
Ever had bowel cancer screening	0.9	1.1	3.0	0.5	-1.7	-0.1
Diabetes diagnosed by doctor	0.4	0.7	1.9	-0.2	-1.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.4	1.0	-1.8	-0.3
Friendships satisfaction	0.2	0.2	0.3	-0.5	-0.5	-0.4
Qualifications: nursing, teaching	0.7	1.1	2.2	-1.5	0.4	1.0
Commuting to job workplace: Walk	1.1	1.2	1.7	-0.9	-1.0	1.3
Eye problems/disorders: Cataract	0.4	0.5	1.0	0.6	0.2	-1.0
Mouth/teeth dental problems: Mouth ulcers	4.3	6.8	14.9	3.9	-2.4	-0.1
Medication for cholesterol	1.5	2.2	4.5	0.6	1.3	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	5.5	0.5	-0.1	2.3
Back pain experienced in last month	1.3	1.9	4.9	0.8	2.2	-0.2
Mineral and other dietary supplements	0.6	0.8	2.0	-0.6	-0.2	-1.4
Breast cancer (self-reported)	1.1	1.3	2.6	-1.6	-0.1	1.1
Asthma (self-reported)	0.9	1.7	2.7	-1.1	-1.1	-1.6
Osteoporosis (self-reported)	1.3	1.6	4.8	2.2	-0.3	-0.0
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.5	-0.5	-0.3
Medication: Aspirin	0.5	0.7	1.2	-0.3	-0.9	-1.1
Medication: Gliclazide	0.1	0.1	0.2	-0.2	-0.5	0.3
Illnesses of father: None of the above (group 1)	0.3	0.4	1.0	0.4	-1.0	-0.3
Smoking status: Current	0.2	0.4	0.5	-0.6	0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.0	0.2	1.0	0.6
Whole body water mass	0.8	4.6	11.3	-1.6	0.5	3.4
Leg predicted mass (right)	1.0	5.2	11.6	-1.5	1.4	3.4
Arm fat mass (left)	1.6	6.4	14.8	-1.8	3.8	-1.1
Number of self-reported non-cancer illnesses	1.4	2.4	6.2	0.9	-0.7	-2.5
Average weekly champagne plus white wine intake	0.5	0.7	1.3	-1.1	-0.7	0.6
Miserableness	0.6	1.1	1.8	1.1	0.3	-1.3
Guilty feelings	0.4	0.6	1.1	-0.8	-1.0	-0.4
Wears glasses or contact lenses	0.3	0.4	0.6	-0.2	0.8	0.7
Ever taken oral contraceptive pill	1.9	2.2	3.8	-1.0	2.0	-1.3
Hearing aid user	1.0	1.1	1.8	-1.4	0.6	1.1
Mother’s age at death	0.3	0.4	0.7	0.8	-0.3	-0.5
Financial situation satisfaction	0.1	0.2	0.4	0.1	0.3	0.6
Tinnitus: Yes, now most or all of the time	2.2	2.6	7.3	0.7	-0.2	2.7
Commuting to job workplace: Public transport	0.5	0.6	1.2	0.8	0.2	1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	0.7	-0.6	1.1
Medication: Blood pressure	2.3	4.3	6.0	-1.4	-2.2	-2.4
Pain type(s) experienced in last month: Hip pain	1.4	1.8	4.2	-0.1	1.0	-2.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.6	-0.5	-0.4	1.6
High cholesterol (Self-reported)	1.6	2.9	6.1	0.8	-2.5	-1.4
Medication: Bendroflumethiazide	1.9	2.8	7.7	-0.9	0.2	-2.8
Medication: Paracetamol	1.1	1.8	3.7	1.2	-0.3	-1.9
Medication: Lisinopril	0.9	1.1	2.4	1.6	-0.2	-0.9
Medication: Atorvastatin	0.6	0.8	1.6	-0.6	-1.3	-0.5
Illnesses of father: High blood pressure	0.3	0.4	1.1	-0.3	-1.1	0.1
Alcohol drinker status: Never	0.9	1.1	2.0	1.4	0.8	0.7
Ever smoked	0.2	0.4	0.5	0.7	-0.7	0.4
Basal metabolic rate	0.8	4.2	7.6	-1.8	1.3	2.8
Leg fat percentage (left)	2.5	9.1	18.8	-2.0	4.3	-2.1
Arm fat-free mass (left)	0.8	4.0	9.4	-1.5	0.5	3.1
Number of operations (self-reported)	1.0	1.5	3.8	0.8	0.1	1.9
Average weekly beer plus cider intake	3.9	5.7	8.2	2.9	-2.3	-1.9
Irritability	1.0	1.7	2.9	1.4	-0.6	-1.7
Risk taking	0.0	0.0	0.1	0.3	-0.1	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.4	-0.1	0.2
Fractured/broken bones in last 5 years	0.8	1.0	2.2	-0.7	-0.7	-1.5
Age started oral contraceptive pill	0.3	0.4	0.9	0.9	-0.3	0.3
Diastolic blood pressure, automated reading	1.4	4.3	11.8	-0.8	0.8	-3.4
Ever depressed for a whole week	0.7	0.9	2.4	1.6	-0.4	-0.3
Unable to work because of sickness or disability	1.7	2.2	6.1	2.5	0.6	0.1
Commuting to job workplace: Cycle	0.6	0.7	1.5	-0.2	-1.2	-0.8
Myopia	0.7	1.1	1.4	-0.7	-1.2	-1.1
Vascular/heart problems diagnosed by doctor	1.6	4.3	12.7	0.3	0.1	3.6
Cholesterol lowering medication	0.7	1.1	3.1	0.2	-1.8	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	0.3	0.2	-0.2
Pain experienced in last month	1.0	1.7	4.6	-0.3	-2.1	0.6
Supplements: Calcium	4.0	4.4	8.6	2.9	-1.5	1.5
Basal cell carcinoma (self-reported)	0.7	0.8	1.8	0.1	-0.9	1.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	0.6	0.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	-1.1	-0.0	-0.1
Heart disease (siblings)	0.6	0.7	1.7	-1.3	-0.5	-0.5
Alcohol drinker status: Previous	0.8	0.9	1.8	-0.8	-1.3	-0.7
Pack years of smoking	0.2	0.2	0.4	-0.1	0.5	-0.6
Impedance of whole body	1.1	5.6	11.9	1.0	2.0	-3.5
Leg fat mass (left)	1.8	7.0	17.4	-1.8	4.2	-0.6
Arm predicted mass (left)	0.7	3.7	8.6	-1.6	0.2	2.9