Hub : Genes

ATP2B4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1640 0.0480 7.3e-04 -0.003 NA -0.002 NA -0.003 7.9e-01 NA 5.5e-01 NA 8.1e-01
2 METSIM Adipose 0.0879 0.0262 1.3e-04 0.070 0.036 0.084 0.059 0.089 9.9e-11 3.3e-06 1.5e-12 3.5e-09 3.0e-13
3 YFS Blood 0.1305 0.0252 1.6e-13 0.079 0.045 0.059 0.072 0.079 1.0e-24 1.7e-14 8.8e-19 1.9e-22 1.0e-24

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.1 0.3 -0.2 0.0 0.5
Bipolar Disorder or Schizophrenia 0.1 0.2 0.5 -0.1 0.0 0.7
Depressed Affect (Nagel 2018) 0.4 0.9 1.8 1.3 0.7 -0.6
Depression (Nagel 2018) 1.0 1.5 2.3 1.4 1.5 0.6
Intelligence (Savage-Jansen 2018) 0.2 0.5 0.9 -0.8 -0.1 -1.0
Neuroticism (Nagel 2018) 0.4 0.9 2.0 1.4 0.5 -0.7
Schizophrenia (2018) 0.0 0.1 0.2 0.1 0.0 0.5
Schizophrenia vs Biploar Disorder 0.5 0.7 2.1 -1.5 0.0 -0.1
Worry (Nagel 2018) 0.1 0.3 0.5 0.7 0.5 0.2
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 -0.5 0.0 0.4
Alzheimer’s Disease (in father) 1.0 1.1 1.8 -1.4 0.9 0.8
Alzheimer’s Disease (including proxy) 0.4 0.6 1.1 -1.0 0.6 0.5
Crohns Disease (2017) 0.5 1.1 2.0 1.4 -0.8 0.8
Irritable Bowel Disease (IBD) 1.0 2.3 5.0 2.2 -1.4 -0.1
Ulcerative Colitis (UC) 1.1 2.0 4.0 2.0 -1.2 -0.8
Major Depression (MDD) 0.3 0.4 0.6 0.3 0.6 -0.8
Reaction Time 0.3 0.6 1.2 -0.8 -0.1 1.1
Verbal and Numeric Reasoning (VNR) 0.7 1.8 4.8 -0.1 -0.7 -2.2
Breast Cancer 1.2 3.0 4.3 1.1 -2.1 -1.9
Ovarian Cancer 2.1 2.8 4.9 -1.7 -0.8 2.2
Prostate Cancer 0.4 0.6 1.0 0.1 0.8 1.0
Age at First Birth 0.9 1.4 4.1 -0.0 -0.1 2.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.2 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.2 0.6 -0.2 0.0 0.8
Coronary Artery Disease (CAD) 0.3 0.3 1.0 1.0 0.0 -0.0
Crohns Disease (2012) 0.6 1.0 2.8 1.7 0.0 0.4
Mean Putamen Volume 1.4 1.6 2.7 -1.4 0.0 1.6
Fasting Glucose 0.9 1.1 1.9 -0.5 -1.0 -1.4
HbA1C 1.7 1.8 3.5 -1.9 -1.4 0.3
HDL Cholesterol 0.2 0.4 0.9 -0.6 0.0 0.9
LDL Cholesterol 0.1 0.1 0.4 0.2 0.0 0.6
Lupus 0.3 0.4 1.1 -1.1 -0.3 0.1
Neuroticism (2016) 0.4 0.6 0.9 0.9 0.9 0.3
Primary Biliary Cirrhosis 1.0 1.4 3.6 1.9 0.0 -0.7
Rheumatoid Arthritis 0.2 0.3 0.6 0.5 0.0 0.8
Schizophrenia (2014) 0.1 0.3 0.7 -0.5 0.0 0.8
Triglycerides 0.1 0.2 0.7 0.8 0.0 -0.3
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.1 1.0 0.0 0.4
Ulcerative Colitis 0.7 1.1 3.2 1.8 0.0 0.1
Blood Eosinophil Count 0.2 1.3 3.6 -1.9 0.4 -0.5
Blood Platelet Count 0.4 4.2 10.3 -1.1 0.9 3.2
Blood Red Count 0.5 4.5 11.2 1.1 -1.0 3.4
Blood White Count 0.2 1.3 3.1 1.8 0.7 0.5
Heel T-Score 0.3 2.3 6.6 -0.1 -0.7 -2.6
BMI 1.2 7.2 20.2 -1.2 4.5 -0.2
Height 0.6 11.2 30.6 -1.4 1.0 5.5
Waist Hip Ratio (WHR) 2.0 9.1 24.5 -1.2 -5.0 1.1
Systolic Blood Pressure 1.4 7.1 9.5 -1.9 -3.1 -2.8
Smoking Status 0.8 1.9 4.2 -1.2 0.3 -2.0
Allergy or Eczema 0.7 1.8 2.8 0.5 1.6 -1.7
Cardiovascular Disease 1.9 6.1 15.7 -1.4 -0.8 -4.0
Hypothyroidism (self reported) 0.1 0.3 0.7 -0.5 0.8 0.2
Respiratory disease 0.1 0.3 0.5 -0.2 -0.7 -0.5
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.3 -0.5 0.4 -0.6
Lung FEV1/FVC ratio 0.3 1.6 4.7 0.3 -0.2 -2.2
Lung FVC 0.1 0.7 1.8 0.5 1.3 0.4
Neuroticism 0.6 1.5 2.5 1.2 -1.6 -0.7
Chronotype (morning person) 0.9 2.1 4.5 0.7 -2.1 1.1
Hair Pigment 0.1 2.3 5.1 0.3 -2.2 1.3
Tanning 0.3 3.3 4.8 2.2 1.2 -1.9
Hand grip strength (left) 0.1 0.4 0.6 -0.8 0.7 0.1
Number of treatments/medications taken 1.8 3.2 7.4 1.2 -0.8 -2.7
Average weekly spirits intake 0.7 0.8 1.0 -0.9 0.8 -1.0
Sensitivity / hurt feelings 0.3 0.5 0.9 0.3 -0.9 0.7
Frequency of depressed mood in last 2 weeks 1.2 1.7 2.5 1.6 0.7 1.5
Hearing difficulty/problems: Yes 0.1 0.2 0.4 0.5 0.6 -0.0
Relative age of first facial hair 0.8 1.7 2.6 1.3 -1.6 -0.9
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.0 0.6 -0.3 1.4
Ever used hormone-replacement therapy (HRT) 0.9 1.2 2.9 -1.7 0.7 -0.3
Ever had hysterectomy (womb removed) 0.5 0.6 0.7 -0.6 0.8 0.8
Systolic blood pressure, automated reading 1.0 2.8 5.1 -1.2 -2.3 -1.4
Eye problems/disorders: Diabetes related eye disease 3.4 3.7 6.5 -2.1 0.3 -2.5
Angina 0.2 0.3 0.6 0.6 0.8 -0.1
Medication for hormone replacement therapy 0.5 0.6 1.4 -0.0 0.5 -1.2
Vitamin and mineral supplements 0.2 0.3 0.6 0.5 -0.7 -0.2
Supplements: Zinc 1.6 1.7 2.8 1.7 -1.3 -0.8
Medication: Co-codamol 0.3 0.3 0.8 0.9 0.1 -0.2
Medication: Metformin 0.4 0.6 1.7 0.1 -1.3 0.2
Diabetes (father) 0.9 1.2 3.1 -0.1 0.6 1.8
Diabetes (mother) 0.8 1.1 2.6 -0.6 -1.6 0.5
Severe depression (siblings) 0.1 0.1 0.3 -0.4 -0.5 -0.0
Pack years adult smoking proportion 0.2 0.3 0.7 -0.1 0.3 -0.8
Impedance of leg (right) 0.9 4.2 10.8 0.4 1.3 -3.3
Leg fat-free mass (left) 0.8 4.3 7.2 -1.6 1.8 2.7
Trunk fat percentage 3.3 13.2 30.7 -1.8 5.5 -2.3
Hand grip strength (right) 0.3 0.8 1.5 -0.9 1.2 -0.1
Townsend deprivation index at recruitment 1.3 1.8 4.7 0.7 -2.2 0.5
Current tobacco smoking 0.2 0.3 0.6 -0.6 0.8 -0.0
Average weekly fortified wine intake 1.1 1.3 2.3 0.8 1.5 -0.9
Maternal smoking around birth 1.7 2.4 3.0 -1.7 1.7 -1.2
Fed-up feelings 0.0 0.1 0.1 -0.2 0.1 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.6 0.0 0.8 -0.0
Relative age voice broke 2.6 3.9 8.7 0.4 -2.9 -1.7
Taking other prescription medications 0.5 0.8 1.3 1.1 -0.3 -1.0
Age when periods started (menarche) 0.5 1.3 2.6 0.9 0.7 1.6
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 3.2 -0.5 0.6 1.8
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.2 10.1 -2.3 0.4 -3.2
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.7 -0.4 -1.9 1.2
Qualifications: CSEs or equivalent 1.1 1.5 2.5 -0.6 1.6 -1.3
Serious illness, injury or assault to yourself 0.6 0.7 1.0 1.0 -0.9 -0.7
High blood pressure 1.8 5.0 14.7 -0.3 -0.5 -3.8
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.8 0.3 1.0 -1.7
Multivitamins +/- minerals 0.4 0.5 0.8 -0.8 0.2 -0.9
Stomach or abdominal pain in last month 0.2 0.3 0.6 -0.8 0.5 0.1
Supplements: Glucosamine 0.6 0.8 0.8 0.9 0.9 0.9
Diverticular disease/diverticulitis (self-reported) 2.6 3.1 5.7 0.9 -1.6 -2.4
Medication: Atenolol 3.3 4.1 10.8 -0.3 -1.2 -3.3
Medication: Levothyroxine sodium 0.7 1.3 2.1 1.3 0.2 1.5
Sitting height 0.7 4.9 13.3 -0.8 -0.9 3.6
Chronic bronchitis/emphysema (father) 0.1 0.2 0.3 0.3 -0.6 -0.2
High blood pressure (mother) 0.0 0.0 0.1 -0.1 -0.4 -0.1
Body mass index (BMI) 1.3 5.4 12.0 -2.0 3.5 -0.6
Impedance of leg (left) 0.8 4.0 10.3 0.7 1.1 -3.2
Leg predicted mass (left) 0.9 4.6 7.9 -1.6 1.8 2.8
Trunk fat mass 2.4 10.2 25.9 -1.8 5.1 -1.1
Waist circumference 1.8 6.7 16.2 -2.0 4.0 0.1
Number of incorrect matches in round 0.3 0.5 1.2 1.1 -0.3 0.2
Past tobacco smoking 0.1 0.2 0.2 -0.3 0.4 0.5
Alcohol usually taken with meals 0.3 0.5 1.5 -0.1 0.1 -1.2
Nervous feelings 0.1 0.3 0.5 0.6 -0.7 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.0 0.9 1.0 -0.2
Hearing difficulty/problems with background noise 0.2 0.3 0.9 0.9 -0.0 -0.4
Hair/balding pattern: Pattern 2 0.5 0.7 1.7 0.1 -1.3 -0.5
Had menopause 0.1 0.1 0.3 -0.2 0.5 -0.0
Had other major operations 0.5 0.6 1.4 -0.7 0.1 1.2
Forced vital capacity (FVC) 0.3 1.1 2.3 0.5 0.8 1.5
Heel bone mineral density (BMD) T-score, automated (right) 2.1 4.7 11.2 -1.6 0.5 -3.3
Ever unenthusiastic/disinterested for a whole week 1.8 2.1 3.3 0.9 -1.5 -1.8
Qualifications: None of the above 0.3 0.6 1.2 0.4 -1.1 0.6
Financial difficulties in last 2 years 0.7 1.0 2.0 0.9 -0.5 1.4
Mouth/teeth dental problems 0.6 0.9 2.2 -0.1 1.5 -0.6
Heart attack 0.1 0.1 0.2 0.4 0.3 -0.2
Allergy 0.7 1.7 5.1 0.2 0.1 2.2
Pain all over the body in last month 0.4 0.4 1.0 0.1 -1.0 0.4
Diabetes (self-reported) 0.3 0.5 1.0 -0.3 -1.0 -0.4
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.9 -0.0 -0.1 -1.4
Medication: Ramipril 0.4 0.5 0.8 -0.4 -0.9 -0.7
Medication: Simvastatin 1.1 1.6 2.4 1.6 -0.9 -1.2
Fluid intelligence score 0.9 1.9 5.1 0.8 0.2 -2.3
Illnesses of siblings 0.6 0.8 1.4 1.2 1.1 -0.1
Neuroticism score 0.5 1.1 2.3 1.5 -0.7 -0.7
Weight 1.2 6.0 11.7 -2.3 3.4 1.0
Impedance of arm (right) 1.3 6.2 10.0 1.1 2.7 -3.2
Arm fat percentage (right) 2.2 8.8 19.0 -1.5 4.4 -2.3
Trunk fat-free mass 0.8 4.8 12.7 -1.4 -0.1 3.6
Hip circumference 3.7 16.0 44.2 -1.9 6.7 -0.4
Time employed in main current job 0.0 0.0 0.1 0.2 0.1 -0.2
Alcohol intake versus 10 years previously 0.5 0.7 1.6 -0.4 1.2 0.6
Father’s age at death 0.2 0.3 0.6 0.8 -0.3 -0.2
Worrier / anxious feelings 0.3 0.6 1.0 1.0 0.5 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 -0.5 0.1 -0.6
Falls in the last year 0.4 0.6 1.2 1.1 -0.5 0.6
Hair/balding pattern: Pattern 3 0.7 1.1 1.6 -1.2 0.1 1.3
Number of live births 0.4 0.6 1.2 -0.6 1.1 0.3
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 1.5 0.5 1.2 1.2
Pulse rate 1.0 1.7 4.0 2.0 1.0 -0.2
Happiness 1.1 1.3 3.1 1.8 0.8 0.5
Noisy workplace 0.2 0.3 0.4 -0.4 0.5 -0.6
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.2 -0.5 -0.2 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.6 -1.6 -0.2 0.0
Mouth/teeth dental problems: Dentures 0.8 1.4 3.2 -1.8 0.3 0.9
Asthma 0.9 1.8 3.5 -0.9 -1.1 -1.9
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.6 1.7 0.0 -0.1 -1.3
Medication: Cholesterol lowering 1.2 1.8 4.0 2.0 -1.0 -0.7
Depression (self-reported) 1.2 1.4 3.6 0.3 1.9 -0.8
Medication: Lansoprazole 0.2 0.3 0.4 0.2 0.6 -0.6
Prospective memory result 2.2 2.7 4.3 2.1 -1.0 1.6
Lung cancer (father) 0.7 0.8 1.1 1.0 1.0 0.6
Illnesses of mother 0.0 0.1 0.1 0.2 0.0 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 2.2 0.7 1.5 0.9
Pulse wave Arterial Stiffness index 2.9 3.4 8.6 0.2 -1.2 2.9
Impedance of arm (left) 1.4 6.4 11.2 0.8 2.7 -3.3
Arm fat mass (right) 1.3 5.6 12.7 -1.7 3.6 -1.0
Trunk predicted mass 0.8 4.7 12.5 -1.3 -0.1 3.5
Standing height 0.5 4.8 14.0 -0.6 0.4 3.7
Length of working week for main job 0.6 0.6 1.3 -0.2 -0.7 -1.1
Exposure to tobacco smoke at home 0.7 0.8 1.9 0.8 1.4 0.0
Breastfed as a baby 0.6 0.7 1.8 0.1 -0.5 1.4
Tense / ‘highly strung’ 3.1 5.2 11.6 3.4 -0.5 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 4.6 1.8 2.1 -0.2
Hair/balding pattern: Pattern 4 0.2 0.6 1.3 -1.1 -0.0 0.7
Birth weight of first child 0.3 0.5 1.2 0.4 1.1 0.1
Peak expiratory flow (PEF) 0.5 1.1 3.3 -0.3 1.8 0.1
Pulse wave reflection index 1.7 2.1 4.1 0.5 -1.4 2.0
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.1 -0.2 0.2 -1.0
Loud music exposure frequency 0.4 0.4 0.9 0.4 -0.3 -1.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.2 0.2 1.5 -0.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.3 -0.3 -1.1 -1.0
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.9 0.3 0.5
Medication: Paracetamol 0.9 1.4 3.5 0.7 -0.5 -1.9
Headache pain in last month 0.5 0.8 2.1 0.3 1.4 -0.5
Medication for cholesterol, blood pressure or diabetes 1.8 3.0 4.6 -2.0 -0.5 2.1
Glaucoma (self-reported) 1.1 1.3 2.7 1.1 0.2 1.6
Gout (self-reported) 0.6 0.9 2.5 -0.0 1.6 -0.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.5 0.1 1.2 1.0
Medication: Amlodipine 0.5 0.6 1.8 0.4 -0.1 -1.3
Medication: Ventolin 100micrograms inhaler 1.2 1.6 3.2 -0.8 -1.8 0.9
Birth weight 1.1 2.3 5.3 -0.8 2.3 1.0
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.2 1.5 0.8 0.2
High blood pressure (siblings) 0.4 0.6 0.7 -0.8 -0.7 -0.7
Forced vital capacity (FVC), Best measure 0.4 1.4 1.9 0.7 1.3 1.4
Body fat percentage 3.1 12.3 27.5 -2.0 5.2 -2.4
Leg fat percentage (right) 2.9 10.4 21.5 -2.0 4.6 -2.4
Arm fat-free mass (right) 0.9 4.4 10.5 -1.6 0.2 3.2
Exposure to tobacco smoke outside home 0.3 0.4 0.7 0.7 -0.8 -0.3
Comparative body size at age 10 2.1 5.9 9.1 -3.0 0.6 2.9
Number of full brothers 0.7 0.9 1.5 -0.0 1.2 1.1
Worry too long after embarrassment 0.5 0.8 1.8 0.7 -0.2 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 5.2 2.3 -0.2 1.0
Wheeze or whistling in the chest in last year 0.4 0.7 1.9 0.1 -0.4 -1.4
Number of children fathered 0.4 0.5 1.1 -1.0 0.4 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.4 0.3 1.2 -0.0
Age at first live birth 0.3 0.5 1.0 -0.7 -1.0 -0.1
Pulse wave peak to peak time 2.2 2.6 6.4 -0.5 1.2 -2.5
Health satisfaction 1.4 1.9 5.3 -0.4 2.3 0.3
Shortness of breath walking on level ground 0.3 0.3 0.9 -0.2 1.0 -0.2
Qualifications: College or University degree 1.0 3.3 4.6 -1.7 1.5 -2.1
Eye problems/disorders: None of the above 0.0 0.0 0.1 -0.2 0.2 0.3
Mouth/teeth dental problems: Loose teeth 0.9 1.0 2.7 -0.6 1.6 -0.3
Emphysema/chronic bronchitis 0.0 0.0 0.1 -0.3 0.0 -0.2
Medication for pain relief, constipation, heartburn 0.8 1.3 2.3 -0.3 1.2 1.5
Neck or shoulder pain in last month 0.2 0.2 0.6 0.1 0.2 -0.8
Medication: Blood pressure 2.2 3.8 6.9 1.9 1.0 -2.6
Angina (self-reported) 0.4 0.6 1.1 0.7 1.0 -0.3
Migraine (self-reported) 0.7 0.8 2.2 -0.6 1.5 0.1
Medication: Ibuprofen 1.2 1.4 4.2 0.3 0.1 -2.0
Medication: Allopurinol 0.8 1.0 1.6 -0.8 0.9 -1.3
Medication: Omeprazole 0.1 0.1 0.2 0.5 0.3 -0.1
Medication: Seretide 50 evohaler 0.7 0.8 2.2 -1.5 0.3 0.0
Mean time to correctly identify matches 0.8 1.5 2.6 -1.3 -0.0 1.6
Heart disease (mother) 0.9 1.1 2.7 -0.8 0.2 1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.1 3.9 1.5 -0.2 -2.0
Whole body fat mass 2.1 8.9 22.6 -1.8 4.8 -1.0
Leg fat mass (right) 1.9 7.5 18.7 -1.8 4.3 -0.7
Arm predicted mass (right) 0.8 4.2 9.9 -1.6 0.3 3.1
Pulse rate, automated reading 0.9 2.8 7.8 2.8 0.5 0.4
Alcohol intake frequency. 0.1 0.3 0.7 0.9 -0.5 0.0
Comparative height size at age 10 0.5 2.5 2.9 -1.7 1.5 1.5
Number of full sisters 0.3 0.4 1.1 -0.4 -1.0 -0.1
Suffer from ‘nerves’ 0.8 1.3 2.3 1.5 -1.0 -0.7
Overall health rating 0.1 0.2 0.3 -0.4 -0.1 -0.5
Chest pain or discomfort 1.5 2.2 3.8 1.1 1.2 -1.9
Had major operations 1.2 1.4 2.4 -0.8 1.5 1.1
Age at last live birth 1.1 1.6 4.4 0.7 -2.1 -0.0
Family relationship satisfaction 0.4 0.5 1.3 0.1 -1.1 -0.4
Leg pain on walking 0.8 1.0 1.6 -1.3 1.2 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.6 0.8 -0.1 1.3
Commuting to job workplace: Car/motor vehicle 2.2 2.6 7.7 0.1 -0.2 -2.8
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.3 0.4 0.4 -1.1
Medication: Aspirin 0.2 0.3 0.4 0.1 -0.6 -0.7
Supplements: Vitamin C 0.1 0.1 0.2 -0.2 -0.4 -0.4
Knee pain experienced in last month 0.8 1.3 3.5 0.6 1.9 0.1
Hypertension (Self-reported) 2.0 5.5 16.1 0.1 -0.6 -4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 3.6 -0.8 -1.2 -1.9
Illnesses of father: Heart disease 0.9 1.2 2.0 -1.4 1.2 0.1
Illnesses of siblings: Diabetes 0.6 0.8 1.2 -0.9 -0.6 -1.1
Smoking status: Previous 0.1 0.1 0.2 -0.2 -0.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.8 0.6 1.1 1.3
Whole body fat-free mass 0.9 5.1 12.4 -1.6 0.5 3.5
Leg fat-free mass (right) 1.0 5.2 11.6 -1.4 1.4 3.4
Arm fat percentage (left) 2.4 9.5 19.6 -1.7 4.4 -2.5
Average weekly red wine intake 0.6 0.8 1.5 -1.2 -0.8 0.5
Handedness (chirality/laterality): Left-handed 1.1 1.4 2.4 1.6 -0.7 -1.1
Mood swings 0.8 1.5 2.2 1.5 0.9 -1.2
Loneliness, isolation 0.1 0.2 0.3 0.3 0.4 0.6
Long-standing illness, disability or infirmity 0.8 1.3 2.5 1.6 0.6 -1.0
Ever had bowel cancer screening 0.9 1.1 3.0 0.5 -1.7 -0.1
Diabetes diagnosed by doctor 0.4 0.7 1.9 -0.2 -1.4 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 3.4 1.0 -1.8 -0.3
Friendships satisfaction 0.2 0.2 0.3 -0.5 -0.5 -0.4
Qualifications: nursing, teaching 0.7 1.1 2.2 -1.5 0.4 1.0
Commuting to job workplace: Walk 1.1 1.2 1.7 -0.9 -1.0 1.3
Eye problems/disorders: Cataract 0.4 0.5 1.0 0.6 0.2 -1.0
Mouth/teeth dental problems: Mouth ulcers 4.3 6.8 14.9 3.9 -2.4 -0.1
Medication for cholesterol 1.5 2.2 4.5 0.6 1.3 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 5.5 0.5 -0.1 2.3
Back pain experienced in last month 1.3 1.9 4.9 0.8 2.2 -0.2
Mineral and other dietary supplements 0.6 0.8 2.0 -0.6 -0.2 -1.4
Breast cancer (self-reported) 1.1 1.3 2.6 -1.6 -0.1 1.1
Asthma (self-reported) 0.9 1.7 2.7 -1.1 -1.1 -1.6
Osteoporosis (self-reported) 1.3 1.6 4.8 2.2 -0.3 -0.0
Osteoarthritis (self-reported) 0.1 0.2 0.3 0.5 -0.5 -0.3
Medication: Aspirin 0.5 0.7 1.2 -0.3 -0.9 -1.1
Medication: Gliclazide 0.1 0.1 0.2 -0.2 -0.5 0.3
Illnesses of father: None of the above (group 1) 0.3 0.4 1.0 0.4 -1.0 -0.3
Smoking status: Current 0.2 0.4 0.5 -0.6 0.5 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.0 0.2 1.0 0.6
Whole body water mass 0.8 4.6 11.3 -1.6 0.5 3.4
Leg predicted mass (right) 1.0 5.2 11.6 -1.5 1.4 3.4
Arm fat mass (left) 1.6 6.4 14.8 -1.8 3.8 -1.1
Number of self-reported non-cancer illnesses 1.4 2.4 6.2 0.9 -0.7 -2.5
Average weekly champagne plus white wine intake 0.5 0.7 1.3 -1.1 -0.7 0.6
Miserableness 0.6 1.1 1.8 1.1 0.3 -1.3
Guilty feelings 0.4 0.6 1.1 -0.8 -1.0 -0.4
Wears glasses or contact lenses 0.3 0.4 0.6 -0.2 0.8 0.7
Ever taken oral contraceptive pill 1.9 2.2 3.8 -1.0 2.0 -1.3
Hearing aid user 1.0 1.1 1.8 -1.4 0.6 1.1
Mother’s age at death 0.3 0.4 0.7 0.8 -0.3 -0.5
Financial situation satisfaction 0.1 0.2 0.4 0.1 0.3 0.6
Tinnitus: Yes, now most or all of the time 2.2 2.6 7.3 0.7 -0.2 2.7
Commuting to job workplace: Public transport 0.5 0.6 1.2 0.8 0.2 1.1
Eye problems/disorders: Glaucoma 0.6 0.7 1.2 0.7 -0.6 1.1
Medication: Blood pressure 2.3 4.3 6.0 -1.4 -2.2 -2.4
Pain type(s) experienced in last month: Hip pain 1.4 1.8 4.2 -0.1 1.0 -2.0
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.6 -0.5 -0.4 1.6
High cholesterol (Self-reported) 1.6 2.9 6.1 0.8 -2.5 -1.4
Medication: Bendroflumethiazide 1.9 2.8 7.7 -0.9 0.2 -2.8
Medication: Paracetamol 1.1 1.8 3.7 1.2 -0.3 -1.9
Medication: Lisinopril 0.9 1.1 2.4 1.6 -0.2 -0.9
Medication: Atorvastatin 0.6 0.8 1.6 -0.6 -1.3 -0.5
Illnesses of father: High blood pressure 0.3 0.4 1.1 -0.3 -1.1 0.1
Alcohol drinker status: Never 0.9 1.1 2.0 1.4 0.8 0.7
Ever smoked 0.2 0.4 0.5 0.7 -0.7 0.4
Basal metabolic rate 0.8 4.2 7.6 -1.8 1.3 2.8
Leg fat percentage (left) 2.5 9.1 18.8 -2.0 4.3 -2.1
Arm fat-free mass (left) 0.8 4.0 9.4 -1.5 0.5 3.1
Number of operations (self-reported) 1.0 1.5 3.8 0.8 0.1 1.9
Average weekly beer plus cider intake 3.9 5.7 8.2 2.9 -2.3 -1.9
Irritability 1.0 1.7 2.9 1.4 -0.6 -1.7
Risk taking 0.0 0.0 0.1 0.3 -0.1 0.1
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.4 -0.1 0.2
Fractured/broken bones in last 5 years 0.8 1.0 2.2 -0.7 -0.7 -1.5
Age started oral contraceptive pill 0.3 0.4 0.9 0.9 -0.3 0.3
Diastolic blood pressure, automated reading 1.4 4.3 11.8 -0.8 0.8 -3.4
Ever depressed for a whole week 0.7 0.9 2.4 1.6 -0.4 -0.3
Unable to work because of sickness or disability 1.7 2.2 6.1 2.5 0.6 0.1
Commuting to job workplace: Cycle 0.6 0.7 1.5 -0.2 -1.2 -0.8
Myopia 0.7 1.1 1.4 -0.7 -1.2 -1.1
Vascular/heart problems diagnosed by doctor 1.6 4.3 12.7 0.3 0.1 3.6
Cholesterol lowering medication 0.7 1.1 3.1 0.2 -1.8 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.0 0.1 0.1 0.3 0.2 -0.2
Pain experienced in last month 1.0 1.7 4.6 -0.3 -2.1 0.6
Supplements: Calcium 4.0 4.4 8.6 2.9 -1.5 1.5
Basal cell carcinoma (self-reported) 0.7 0.8 1.8 0.1 -0.9 1.3
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.4 0.6 0.4 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.1 -1.1 -0.0 -0.1
Heart disease (siblings) 0.6 0.7 1.7 -1.3 -0.5 -0.5
Alcohol drinker status: Previous 0.8 0.9 1.8 -0.8 -1.3 -0.7
Pack years of smoking 0.2 0.2 0.4 -0.1 0.5 -0.6
Impedance of whole body 1.1 5.6 11.9 1.0 2.0 -3.5
Leg fat mass (left) 1.8 7.0 17.4 -1.8 4.2 -0.6
Arm predicted mass (left) 0.7 3.7 8.6 -1.6 0.2 2.9