TWAS hub - ATP6V0B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.363	0.1050	3.4e-03	-0.004	NA	0.006	NA	0.020	5.2e-01	NA	1.6e-01	NA	3.6e-02
2	GTEx	Esophagus Muscularis	0.478	0.0760	9.2e-07	-0.004	NA	0.033	NA	-0.002	8.3e-01	NA	4.3e-03	NA	4.7e-01
3	GTEx	Testis	0.258	0.1050	1.4e-03	-0.004	NA	0.019	NA	0.010	5.3e-01	NA	4.5e-02	NA	1.1e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.315	0.0510	0.0e+00	0.203	0.162	0.190	0.207	0.197	1.6e-25	2.7e-20	8.3e-24	5.0e-26	1.0e-24
5	YFS	Blood	0.405	0.0645	0.0e+00	0.040	0.090	0.122	0.125	0.094	4.5e-13	9.2e-28	9.4e-38	9.2e-39	5.1e-29

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Qualifications: O levels/GCSEs or equivalent	7.2	11.5	18.9	-2.8	-2.7	-3.6	-3.2	-4.3
Medication for hormone replacement therapy	5.7	6.3	11.6	2.3	1.3	2.3	2.8	3.4
Bilateral oophorectomy (both ovaries removed)	5.0	5.7	8.2	2.5	2.9	2.4	2.0	2.2
Current tobacco smoking	4.2	6.8	13.8	2.0	3.7	3.0	1.8	2.0
Illnesses of father: Heart disease	4.2	5.8	10.8	-2.6	-3.3	-1.2	-2.8	-1.6
Smoking status: Current	4.0	6.3	13.5	1.9	3.7	2.9	1.6	1.8
Reason for reducing amount of alcohol drunk: Health precaution	3.8	4.4	6.5	1.9	2.5	2.4	1.3	2.1
Fluid intelligence score	3.5	7.3	12.2	-2.3	-2.1	-3.5	-1.7	-3.4
Had menopause	3.4	4.2	6.6	2.6	1.4	1.9	1.9	2.4
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	6.2	-2.5	-1.8	-2.0	-1.6	-1.9
Family relationship satisfaction	3.2	3.9	9.0	2.0	0.4	1.9	1.7	3.0
Smoking Status	3.1	7.5	9.4	2.2	3.1	2.9	2.4	3.0
Leg pain on walking	3.0	3.8	5.7	1.5	2.4	1.4	2.1	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	6.0	1.6	1.0	2.1	1.9	2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.9	3.8	6.0	2.5	1.9	1.1	1.6	2.3
Chronotype (morning person)	2.7	6.3	9.3	-2.2	-3.0	-1.7	-2.7	-2.7
Qualifications: nursing, teaching	2.7	4.1	7.4	-1.2	-1.3	-2.7	-1.8	-2.6
Ever had hysterectomy (womb removed)	2.6	3.0	4.7	1.9	1.6	2.2	0.7	1.9
Hearing difficulty/problems with background noise	2.6	4.2	7.2	1.3	-0.0	2.4	2.7	2.5
Ever used hormone-replacement therapy (HRT)	2.5	3.2	5.2	1.6	0.3	1.8	2.2	2.3
Intelligence (Savage-Jansen 2018)	2.3	7.0	11.3	-2.9	-2.5	-3.4	-2.0	-2.3
HbA1C	2.3	2.5	4.9	1.7	1.1	1.4	1.3	2.2
Loud music exposure frequency	2.2	2.4	3.8	1.6	0.9	1.9	1.0	2.0
Risk taking	2.2	3.2	4.2	1.6	1.6	2.0	1.7	2.0
Supplements: Calcium	2.2	2.4	7.1	2.7	1.5	1.3	0.9	0.3
Qualifications: None of the above	2.1	4.4	10.1	0.9	1.3	2.9	0.9	3.2
Qualifications: A levels/AS levels or equivalent	2.1	4.6	11.7	-0.7	-1.5	-2.6	-1.4	-3.4
Mouth/teeth dental problems: Dentures	2.1	3.6	5.8	0.8	1.5	2.4	1.8	2.4
Medication: Lisinopril	2.1	2.7	6.7	-1.5	-0.2	-1.4	-1.6	-2.6
Loneliness, isolation	2.0	2.7	7.3	1.1	-0.4	1.3	1.8	2.7
Irritability	2.0	3.4	8.2	2.2	1.1	-0.3	2.9	1.5
Maternal smoking around birth	1.9	2.8	8.9	1.3	1.4	1.1	0.6	3.0
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	4.1	-0.8	-1.3	-2.0	0.1	-2.0
Allergy	1.9	4.4	8.1	-2.0	-2.7	-0.9	-2.8	-1.2
Chronic bronchitis/emphysema (mother)	1.9	2.2	3.3	1.8	1.2	1.8	1.0	1.4
Mean time to correctly identify matches	1.9	3.6	15.5	0.3	0.0	3.9	0.9	1.3
Crohns Disease (2012)	1.7	2.8	6.2	-2.5	-1.5	0.5	-2.2	-0.8
Financial situation satisfaction	1.7	2.1	4.4	2.1	0.9	0.5	1.8	1.2
Commuting to job workplace: Public transport	1.7	2.0	3.5	-1.6	-0.4	-1.8	-0.8	-1.9
Eye problems/disorders: Glaucoma	1.7	2.0	3.9	1.2	-1.1	-0.2	1.8	2.0
Alcohol drinker status: Never	1.7	2.0	4.2	-1.3	-1.6	2.0	-1.2	-0.2
Reaction Time	1.6	3.0	10.6	0.5	-0.3	3.2	1.4	1.5
Multivitamins +/- minerals	1.6	2.1	3.3	1.2	1.6	1.8	1.1	1.4
Mouth/teeth dental problems	1.6	2.4	3.9	-1.7	-2.0	-0.6	-1.9	-1.1
Length of working week for main job	1.6	1.7	3.9	-2.0	-0.9	-0.9	-1.6	-0.8
Miserableness	1.6	2.8	7.0	-1.9	-1.1	-2.6	-0.8	-1.3
Mother’s age at death	1.6	2.0	5.3	-1.5	-2.3	-0.2	-1.3	-0.9
Average weekly beer plus cider intake	1.6	2.4	4.2	1.0	1.5	1.1	2.0	1.8
Illnesses of siblings: Diabetes	1.5	1.9	6.3	1.1	0.8	2.5	0.6	0.8
Illnesses of father: None of the above (group 1)	1.5	1.8	5.0	1.3	2.2	0.6	1.3	0.6
Supplements: Fish oil (including cod liver oil)	1.5	1.9	5.4	-1.0	-0.4	-1.0	-1.4	-2.3
Heart disease (siblings)	1.5	1.9	3.5	-0.2	-1.0	1.2	-1.8	-1.9
HDL Cholesterol	1.4	2.3	5.4	1.9	0.4	1.2	2.3	0.9
Townsend deprivation index at recruitment	1.4	2.0	6.0	-2.4	-1.3	-0.5	-1.3	-0.6
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.8	1.5	1.9	0.8	2.6	1.2
Noisy workplace	1.4	1.7	6.0	-0.5	-0.1	2.5	-0.1	1.5
Breastfed as a baby	1.4	1.8	4.1	1.6	1.2	0.7	2.0	0.5
Ever highly irritable/argumentative for 2 days	1.4	1.6	4.0	1.2	2.0	1.2	0.8	0.8
Number of children fathered	1.4	1.6	5.1	1.2	0.6	0.1	2.3	1.0
Ever depressed for a whole week	1.4	1.7	4.4	1.0	-0.9	1.0	1.3	2.1
Alzheimer’s Disease (in father)	1.3	1.5	2.7	1.3	0.5	1.5	0.6	1.6
Respiratory disease	1.3	2.9	7.2	1.6	2.7	1.8	1.2	0.5
Asthma	1.3	2.6	7.3	1.9	2.7	1.2	0.6	0.0
Tense / ‘highly strung’	1.3	2.2	4.9	2.2	1.9	0.5	1.4	-0.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	1.8	-1.3	-1.4	-0.8	-1.2	-1.3
Schizophrenia (2018)	1.2	2.6	6.5	1.1	1.8	2.5	0.3	1.4
Ulcerative Colitis (UC)	1.2	2.3	4.6	1.2	1.7	1.1	2.1	1.1
Allergy or Eczema	1.2	3.3	8.9	1.6	1.8	0.6	3.0	1.1
Average weekly spirits intake	1.2	1.5	5.7	-0.3	0.3	2.4	-0.7	0.9
High blood pressure (mother)	1.2	1.7	3.1	-1.3	-1.8	-1.5	-1.0	-0.6
Qualifications: College or University degree	1.2	3.8	10.7	-0.1	-2.0	-3.3	0.2	-2.1
Had major operations	1.2	1.4	4.2	-0.8	-1.3	-2.0	-0.7	-0.1
Asthma (self-reported)	1.2	2.5	7.9	1.8	2.8	1.0	0.3	-0.3
Alzheimer’s Disease (including proxy)	1.1	1.6	3.4	1.1	0.1	0.7	1.7	1.9
Verbal and Numeric Reasoning (VNR)	1.1	2.6	5.3	-1.7	-1.3	-2.3	-1.2	-1.3
Blood Platelet Count	1.1	12.5	34.8	2.3	5.9	4.2	1.9	-1.0
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.0	-1.3	-1.3	0.8	-1.7	0.1
Had other major operations	1.1	1.3	2.7	-1.0	-1.6	-1.6	0.6	-0.4
Blood clot in the leg (DVT)	1.1	1.5	3.5	0.7	1.1	-0.0	1.9	1.5
Number of full brothers	1.1	1.4	3.0	-1.0	-0.8	0.1	-1.5	-1.7
Age at last live birth	1.1	1.6	5.4	2.3	0.6	-0.3	1.0	-1.0
Guilty feelings	1.1	1.7	2.8	-0.2	-1.6	1.6	-1.7	0.7
Medication: Bendroflumethiazide	1.1	1.6	2.7	1.4	1.2	1.6	1.3	0.5
Medication: Paracetamol	1.1	1.8	4.0	2.0	0.3	1.9	0.2	1.0
Sitting height	1.0	7.1	12.8	-1.4	-3.3	-3.6	-2.2	-2.2
Alcohol intake versus 10 years previously	1.0	1.5	3.8	0.1	0.1	1.9	-1.2	1.5
Glaucoma (self-reported)	1.0	1.1	3.6	0.1	-1.9	-0.5	0.9	1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.2	3.7	0.9	1.9	0.0	0.2	-1.3
High blood pressure (siblings)	1.0	1.4	3.0	-1.3	-1.7	-0.6	-1.1	-0.7
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.7	-0.4	0.2	1.9	-0.6	1.2
Fractured/broken bones in last 5 years	1.0	1.3	3.6	-0.7	-1.9	-1.3	-0.5	-0.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.7	-0.3	-0.6	-1.2	-1.0	-1.3
Serious illness, injury or assault to yourself	0.9	1.1	4.2	0.3	-0.8	2.0	-0.7	-0.2
Financial difficulties in last 2 years	0.9	1.2	4.1	0.7	2.0	1.1	0.3	-0.1
Medication: Ramipril	0.9	1.1	2.4	1.0	1.5	0.9	-0.2	-1.1
Hair/balding pattern: Pattern 3	0.9	1.3	2.4	-0.8	-1.6	-1.1	-0.6	-1.4
Worry too long after embarrassment	0.9	1.6	5.8	0.0	-2.4	-0.2	-1.2	-0.8
Age at first live birth	0.9	1.7	3.0	1.7	0.3	-1.6	0.8	-1.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.8	1.1	1.3	0.0	0.8	1.3
Breast cancer (self-reported)	0.9	1.1	1.5	1.2	1.1	-0.7	1.0	1.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.7	0.5	1.0	-0.2	1.7	1.4
Alcohol drinker status: Previous	0.9	1.0	2.2	1.3	0.1	0.4	1.1	1.5
Ovarian Cancer	0.8	1.0	3.2	1.0	0.9	0.3	1.8	0.1
Age at First Birth	0.8	1.2	2.8	1.7	-0.4	0.2	1.6	0.4
Mean Putamen Volume	0.8	0.9	2.1	-0.6	-0.6	-0.4	-1.5	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.5	1.1	1.6	0.6	0.8	0.6
Worrier / anxious feelings	0.8	1.6	3.3	-0.5	-1.5	-1.0	-1.0	-1.8
Happiness	0.8	0.9	1.8	-1.3	-1.4	-0.8	-0.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.1	-0.5	-0.7	-0.8	-0.0	-1.8
Hair/balding pattern: Pattern 4	0.8	1.9	6.5	1.0	0.2	0.5	1.4	2.5
Pulse wave peak to peak time	0.8	0.9	2.9	0.2	0.2	-1.7	-0.2	-1.3
Migraine (self-reported)	0.8	1.0	3.2	0.7	-0.2	0.0	1.1	-1.8
Eye problems/disorders: Cataract	0.8	0.9	2.2	0.8	0.8	0.6	1.5	0.9
Osteoporosis (self-reported)	0.8	1.0	1.6	-1.0	-1.1	-0.8	-1.3	-0.9
Pack years of smoking	0.8	1.1	3.3	0.8	0.9	0.9	0.4	1.8
Coronary Artery Disease (CAD)	0.7	0.9	1.4	-1.1	-0.7	-1.2	-0.9	-0.6
Neuroticism (2016)	0.7	0.9	3.3	1.0	0.4	0.5	1.8	0.4
Triglycerides	0.7	1.2	2.6	-1.1	-1.6	-1.4	-0.1	0.6
Lung FEV1/FVC ratio	0.7	3.8	6.8	2.0	2.1	1.5	2.6	1.1
Vitamin and mineral supplements	0.7	1.0	2.5	-0.8	-1.2	-1.6	-0.5	-0.4
Pack years adult smoking proportion	0.7	1.0	2.0	0.6	1.1	1.2	0.2	1.4
Age when periods started (menarche)	0.7	1.7	4.9	0.2	2.2	1.1	-0.5	1.4
Medication: Atenolol	0.7	0.9	2.8	1.1	0.6	-0.3	1.7	-0.4
Alcohol usually taken with meals	0.7	1.2	3.5	0.3	-1.9	-1.1	1.0	0.4
Falls in the last year	0.7	1.0	1.9	0.8	0.7	1.0	1.4	0.9
Prospective memory result	0.7	0.8	1.9	1.4	0.3	0.2	0.7	1.3
Pulse wave Arterial Stiffness index	0.7	0.8	2.7	-0.4	-0.3	1.6	-0.0	0.9
Medication: Paracetamol	0.7	1.2	3.1	1.8	0.9	1.5	0.0	-0.2
Overall health rating	0.7	1.5	3.9	1.6	0.4	2.0	0.6	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.6	0.2	0.6	1.9	-0.2	-0.2
Wears glasses or contact lenses	0.7	0.8	1.5	-0.6	-1.0	-1.0	-0.1	1.2
Medication: Atorvastatin	0.7	0.9	2.6	-0.0	-0.7	-0.1	1.1	1.6
Schizophrenia vs Biploar Disorder	0.6	0.8	2.5	1.6	0.9	0.9	-0.2	0.0
Breast Cancer	0.6	1.5	7.3	-0.0	-0.2	2.7	-0.2	0.0
Prostate Cancer	0.6	0.8	1.6	-1.1	-0.6	-0.8	-0.6	-1.3
Relative age of first facial hair	0.6	1.2	3.0	-0.4	-0.9	1.2	-0.7	1.7
Relative age voice broke	0.6	1.0	3.6	-0.4	-0.3	1.0	0.2	1.9
Qualifications: CSEs or equivalent	0.6	0.8	2.5	0.4	0.5	1.6	-0.6	-0.7
Supplements: Glucosamine	0.6	0.8	2.5	-0.7	-1.6	-0.6	-0.5	-0.5
Past tobacco smoking	0.6	1.1	3.5	-0.3	-0.5	-1.9	-0.2	-1.2
Forced vital capacity (FVC)	0.6	2.5	5.2	-1.1	-2.0	-2.3	-1.2	0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.6	-0.6	-0.9	1.0	0.1	1.3
Pain all over the body in last month	0.6	0.6	1.7	0.6	1.3	0.7	-0.2	0.7
Medication: Simvastatin	0.6	0.8	1.6	-0.7	0.9	0.3	-1.1	-1.3
Arm fat percentage (right)	0.6	2.4	9.1	0.7	1.5	3.0	-0.2	0.2
Pulse rate	0.6	1.0	3.1	-0.8	0.2	0.1	-1.2	1.8
Depression (self-reported)	0.6	0.7	1.9	-0.8	0.7	0.4	-0.7	-1.4
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.4	0.2	-0.4	-0.2	1.9	1.0
Gout (self-reported)	0.6	0.9	1.7	0.2	1.3	0.9	1.1	0.8
Body fat percentage	0.6	2.5	9.7	0.7	1.3	3.1	0.5	0.5
Wheeze or whistling in the chest in last year	0.6	1.1	3.0	0.8	0.7	0.3	1.7	1.2
Medication: Allopurinol	0.6	0.8	2.9	-0.1	1.7	1.0	0.3	0.3
Suffer from ‘nerves’	0.6	1.0	2.4	1.0	0.8	1.0	1.5	0.2
Supplements: Vitamin C	0.6	0.8	1.3	1.1	-0.0	1.0	0.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.0	-0.6	-1.7	-1.4	-0.8	-0.4
Arm fat percentage (left)	0.6	2.3	7.8	0.8	1.7	2.8	0.3	0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	0.6	0.7	-1.4	-0.1	-0.9
Mood swings	0.6	1.1	2.5	1.6	-0.4	0.4	1.4	0.9
Ever had bowel cancer screening	0.6	0.7	2.3	-0.4	-0.3	-1.5	-0.7	-0.7
Number of self-reported non-cancer illnesses	0.6	1.1	2.0	1.1	1.4	1.0	1.1	-0.0
Average weekly champagne plus white wine intake	0.6	0.9	1.4	1.2	-0.1	-1.1	0.7	-1.2
High cholesterol (Self-reported)	0.6	1.1	3.5	-1.9	-1.2	-0.4	-0.3	-0.0
Leg fat percentage (left)	0.6	2.3	9.1	0.4	1.1	3.0	0.6	0.7
Cholesterol lowering medication	0.6	0.9	2.5	-1.6	-1.1	-0.3	-0.8	-0.4
Bipolar Disorder (2018)	0.5	0.8	3.1	-1.8	-0.3	-0.7	-0.4	0.4
Bipolar Disorder or Schizophrenia	0.5	1.2	2.4	-0.3	1.2	1.5	-0.0	1.4
Depression (Nagel 2018)	0.5	0.8	2.0	0.8	1.4	0.3	0.7	0.8
Worry (Nagel 2018)	0.5	1.0	1.9	1.4	-0.3	-1.4	0.6	-0.9
Alzheimer’s Disease (in mother)	0.5	0.6	2.0	0.3	0.1	0.2	1.4	0.8
Bipolar Disorder (2011)	0.5	0.5	0.9	0.2	0.7	0.6	0.9	0.7
Rheumatoid Arthritis	0.5	0.7	1.3	-1.1	0.3	0.7	-1.1	-0.7
Blood Red Count	0.5	5.3	13.6	-1.4	-2.9	3.7	-1.5	-0.3
Sensitivity / hurt feelings	0.5	0.9	2.0	-0.6	-1.3	0.4	-1.4	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.4	0.8	1.6	0.6	0.1	-0.5
Hearing difficulty/problems: Yes	0.5	0.7	1.7	0.0	0.0	1.2	1.3	0.8
Supplements: Zinc	0.5	0.5	1.0	1.0	1.0	0.4	0.5	-0.2
Trunk fat percentage	0.5	2.1	7.9	0.7	1.3	2.8	0.6	0.2
Heart attack	0.5	0.6	1.6	-1.0	0.0	0.4	-1.3	-0.6
Diabetes (self-reported)	0.5	0.8	1.3	1.1	0.9	-0.8	0.2	-1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.3	0.5	0.9	0.4	1.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	-0.4	0.3	-0.7	-0.9	-1.2
Illnesses of mother	0.5	0.6	1.3	1.1	0.7	0.4	1.1	0.0
Birth weight of first child	0.5	0.9	2.7	-0.5	-0.6	-0.4	-1.2	-1.6
Peak expiratory flow (PEF)	0.5	1.1	3.1	-0.4	-1.4	-1.8	-0.2	0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	1.1	-1.0	-0.6	0.4	-0.5
Headache pain in last month	0.5	0.9	1.7	1.3	-0.3	0.9	1.0	-0.8
Shortness of breath walking on level ground	0.5	0.6	1.7	-0.1	-0.0	1.2	-0.4	1.3
Long-standing illness, disability or infirmity	0.5	0.8	2.2	-0.5	-0.0	0.5	-1.1	-1.5
Diabetes diagnosed by doctor	0.5	0.8	2.1	0.8	1.4	-0.4	-0.2	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	-0.6	-0.6	0.3	-1.1	-0.8
Commuting to job workplace: Walk	0.5	0.5	1.2	-0.1	1.1	-0.5	-0.1	-1.0
Medication for cholesterol	0.5	0.8	2.0	-0.4	0.4	-1.1	-1.4	-0.8
Mineral and other dietary supplements	0.5	0.7	2.0	0.4	0.5	0.6	0.9	1.4
Osteoarthritis (self-reported)	0.5	0.7	2.5	0.4	-0.4	0.6	1.6	0.7
Basal cell carcinoma (self-reported)	0.5	0.6	1.9	-0.4	-1.0	-1.4	0.1	-0.3
Crohns Disease (2017)	0.4	1.0	2.2	-1.1	0.1	1.0	-1.5	-0.7
Major Depression (MDD)	0.4	0.5	0.8	-0.6	0.9	0.8	-0.3	-0.6
Fasting Glucose	0.4	0.5	1.9	-0.3	-0.5	-1.4	0.1	-0.6
LDL Cholesterol	0.4	0.7	1.5	-0.6	-0.7	-1.2	-1.0	0.2
Schizophrenia (2014)	0.4	0.9	1.9	-0.5	1.3	1.4	-0.8	0.1
Blood Eosinophil Count	0.4	3.1	6.8	-1.2	-1.4	2.6	-1.8	-1.4
Neuroticism	0.4	1.0	2.8	0.8	-1.7	-1.0	-0.1	-0.9
Severe depression (siblings)	0.4	0.5	2.2	0.1	0.1	0.3	-0.2	-1.5
High blood pressure	0.4	1.2	2.9	1.7	0.4	1.5	0.9	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.8	0.4	0.4	-0.2	0.9	1.3
Illnesses of siblings	0.4	0.6	1.1	0.5	0.9	-1.0	0.9	0.4
Trunk fat-free mass	0.4	2.1	4.3	-0.5	-1.7	-1.4	-2.1	-1.1
Number of live births	0.4	0.5	1.6	-0.3	-1.0	-0.0	-1.3	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.6	-0.6	-1.6	-1.6	-0.4	1.2
Lung cancer (father)	0.4	0.4	0.9	-0.3	0.9	-0.9	0.5	-0.1
Trunk predicted mass	0.4	2.2	4.5	-0.6	-1.8	-1.3	-2.1	-1.2
Birth weight	0.4	1.0	3.1	-0.0	0.7	-1.1	0.2	-1.8
Forced vital capacity (FVC), Best measure	0.4	1.6	5.4	-0.7	-1.1	-2.3	-0.9	-0.1
Leg fat percentage (right)	0.4	1.5	6.9	0.1	0.7	2.6	0.1	0.4
Eye problems/disorders: None of the above	0.4	0.5	0.9	-0.6	0.4	-0.3	-0.9	-0.9
Emphysema/chronic bronchitis	0.4	0.5	0.8	0.5	0.9	0.4	-0.8	-0.6
Medication for pain relief, constipation, heartburn	0.4	0.6	1.3	-1.0	-1.2	-0.4	-0.1	0.7
Medication: Blood pressure	0.4	0.8	1.3	1.1	1.1	0.4	-0.9	-0.6
Medication: Omeprazole	0.4	0.5	1.6	0.1	0.6	1.3	0.1	0.8
Heart disease (mother)	0.4	0.5	1.5	-0.4	-0.7	-0.2	-1.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.6	1.3	0.9	0.4	0.0	0.1
Pulse rate, automated reading	0.4	1.2	2.8	-1.0	-0.2	-1.1	-1.7	0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.4	-0.8	-0.3	-0.4	-1.2	0.2
Smoking status: Previous	0.4	0.6	1.5	-0.0	-0.3	1.2	0.1	1.2
Ever smoked	0.4	0.7	2.8	0.4	0.6	1.7	0.0	0.2
Diastolic blood pressure, automated reading	0.4	1.3	4.2	-0.6	-2.0	0.6	-1.2	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.7	-1.4	-0.2	-1.6	-0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	0.4	0.6	1.2	0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.5	-0.8	-0.1	0.5	-1.2	-0.6
Leg fat mass (left)	0.4	1.5	6.0	0.6	0.7	2.5	0.2	0.6
Neuroticism (Nagel 2018)	0.3	0.6	1.4	0.9	-1.2	-0.9	0.2	-0.4
Primary Biliary Cirrhosis	0.3	0.5	1.0	-0.5	-1.0	0.3	-0.7	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.3	-0.7	0.1	-0.4	-1.1	0.0
Systolic Blood Pressure	0.3	1.4	3.2	-0.4	-1.8	-1.2	-1.1	-1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.0	0.5	0.6	-0.8	0.0	-1.4
Lung FVC	0.3	1.5	5.4	0.7	0.1	-0.5	1.2	2.3
Diabetes (father)	0.3	0.4	1.1	0.7	0.3	1.0	0.7	-0.2
Average weekly fortified wine intake	0.3	0.3	1.3	0.2	1.1	-0.6	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.8	-0.2	-0.7	-1.3	-1.0	0.2
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.3	0.4	-0.8	1.0	0.2
Body mass index (BMI)	0.3	1.1	3.9	0.8	0.8	2.0	0.3	0.7
Trunk fat mass	0.3	1.2	4.9	0.5	0.7	2.2	-0.1	-0.1
Number of incorrect matches in round	0.3	0.6	1.1	-0.9	-0.3	0.4	-1.0	-0.8
Nervous feelings	0.3	0.6	1.1	1.1	-0.9	-0.5	0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.9	-0.4	-0.9	-0.9	-1.4	-0.0
Neuroticism score	0.3	0.5	2.3	0.4	-1.5	-0.1	-0.3	-0.2
Impedance of arm (right)	0.3	1.2	3.2	0.5	1.5	1.8	-0.1	-0.5
Arm fat mass (right)	0.3	1.3	5.4	0.7	0.7	2.3	-0.5	0.2
Standing height	0.3	3.0	4.4	-0.3	-2.0	-1.7	-2.1	-2.0
Exposure to tobacco smoke at home	0.3	0.3	1.1	1.0	0.5	0.1	0.4	0.1
Whole body fat mass	0.3	1.2	5.2	0.5	0.6	2.3	-0.2	0.2
Leg fat mass (right)	0.3	1.1	5.1	0.3	0.4	2.2	-0.3	0.3
Alcohol intake frequency.	0.3	0.8	1.3	-1.1	-0.9	0.8	-0.9	0.5
Comparative height size at age 10	0.3	1.6	3.8	0.5	-1.4	-1.1	-0.9	-1.9
Chest pain or discomfort	0.3	0.4	1.2	0.5	0.5	-1.1	-0.1	-0.7
Medication: Aspirin	0.3	0.4	0.9	0.1	0.9	0.1	-0.4	-0.8
Knee pain experienced in last month	0.3	0.4	0.9	0.9	0.4	0.1	0.7	0.8
Hypertension (Self-reported)	0.3	0.8	2.4	1.6	0.3	1.0	0.8	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	-0.7	-0.8	-0.2	0.5	0.4
Average weekly red wine intake	0.3	0.4	1.1	0.4	-0.9	-1.1	0.1	-0.3
Friendships satisfaction	0.3	0.4	0.7	0.8	0.5	0.8	0.3	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	-0.2	0.4	-1.2	-0.8	-0.5
Arm fat mass (left)	0.3	1.3	4.5	0.9	1.0	2.1	-0.2	0.3
Ever taken oral contraceptive pill	0.3	0.4	1.1	-1.1	-0.4	-0.5	0.2	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.6	-0.4	0.7	-0.8	0.6	-0.1
Illnesses of father: High blood pressure	0.3	0.4	1.4	-0.2	0.0	-0.5	-0.6	-1.2
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	0.7	-0.7	-0.4	0.8	0.3
Irritable Bowel Disease (IBD)	0.2	0.6	1.6	0.1	1.1	1.2	0.5	0.1
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	-0.0	-0.5	0.7	-1.0	0.2
Ulcerative Colitis	0.2	0.3	0.8	0.2	0.9	0.4	0.6	0.2
Heel T-Score	0.2	1.3	5.5	-0.4	-0.5	-0.5	-0.7	2.3
BMI	0.2	1.2	3.4	-0.4	-1.8	1.3	-0.9	0.1
Waist Hip Ratio (WHR)	0.2	0.9	1.4	1.2	0.7	0.4	1.0	1.2
Cardiovascular Disease	0.2	0.7	2.4	-0.5	-1.6	0.1	-0.2	-0.9
Hand grip strength (left)	0.2	0.4	1.5	-0.4	-0.1	-1.2	-0.5	0.4
Systolic blood pressure, automated reading	0.2	0.4	1.5	0.0	-1.2	0.3	-0.8	-0.1
Angina	0.2	0.2	0.7	0.2	-0.5	0.8	0.1	0.0
Medication: Metformin	0.2	0.3	0.9	-0.0	0.9	-0.8	0.1	-0.1
Taking other prescription medications	0.2	0.3	0.6	-0.5	0.8	-0.3	0.2	-0.8
Medication: Levothyroxine sodium	0.2	0.4	1.0	0.1	-0.6	0.6	-1.0	-0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.3	-0.6	0.2	0.5	0.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	0.6	0.3	-0.5	0.2	-0.7
Medication: Cholesterol lowering	0.2	0.3	0.9	0.1	0.7	1.0	-0.3	0.2
Medication: Lansoprazole	0.2	0.2	0.6	0.4	-0.3	0.3	0.8	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.9	-0.0	-0.5	-1.7	-0.5	0.1
Impedance of arm (left)	0.2	0.7	1.9	0.3	1.4	1.1	0.6	-0.3
Pulse wave reflection index	0.2	0.2	1.0	0.1	-0.0	1.0	0.2	0.0
Medication: Amlodipine	0.2	0.2	0.6	0.3	-0.1	-0.8	-0.5	-0.6
Exposure to tobacco smoke outside home	0.2	0.3	0.7	0.0	0.8	-0.2	0.7	0.4
Comparative body size at age 10	0.2	0.5	1.0	-0.1	1.0	0.6	0.3	1.0
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.6	0.2	0.4	-0.6	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.1	0.8	-0.3	0.5	-0.4
Medication: Aspirin	0.2	0.2	0.5	0.2	0.7	0.2	0.1	-0.7
Medication: Blood pressure	0.2	0.4	1.3	-0.3	-1.1	0.0	0.8	-0.0
Number of operations (self-reported)	0.2	0.3	0.6	0.4	0.4	-0.3	0.8	0.6
Age started oral contraceptive pill	0.2	0.3	0.7	-0.4	-0.8	-0.6	0.5	-0.3
Unable to work because of sickness or disability	0.2	0.3	0.7	0.0	0.8	0.6	0.5	0.6
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.4	0.7	0.5	0.7	-0.1
Myopia	0.2	0.3	1.1	-0.2	-0.2	-1.0	-0.5	-0.3
Arm predicted mass (left)	0.2	0.9	2.0	0.0	-1.4	-0.7	-1.2	-0.7
Lupus	0.1	0.2	0.3	0.5	-0.2	0.1	0.5	0.5
Blood White Count	0.1	0.5	0.9	0.5	-0.7	-0.9	0.5	-0.9
Height	0.1	2.6	7.0	-0.3	-2.6	-0.6	-2.2	-0.9
Hypothyroidism (self reported)	0.1	0.2	0.3	-0.1	-0.4	0.5	-0.5	-0.3
Hair Pigment	0.1	1.8	6.1	0.8	0.5	0.4	1.4	2.5
Tanning	0.1	1.5	4.6	0.8	-0.3	2.1	0.8	1.3
Number of treatments/medications taken	0.1	0.2	0.8	0.5	0.2	0.2	-0.1	-0.9
Medication: Co-codamol	0.1	0.2	0.4	0.6	0.3	0.2	-0.0	0.5
Diabetes (mother)	0.1	0.2	0.4	-0.1	0.1	0.5	-0.6	-0.4
Impedance of leg (right)	0.1	0.3	0.7	-0.8	-0.3	0.6	-0.6	-0.5
Hand grip strength (right)	0.1	0.2	0.3	-0.5	-0.5	-0.4	-0.4	0.4
Fed-up feelings	0.1	0.2	0.7	0.2	0.2	0.6	0.2	-0.8
Waist circumference	0.1	0.4	1.2	0.6	0.4	1.1	-0.4	0.5
Weight	0.1	0.4	1.4	0.5	0.0	1.2	-0.6	-0.2
Hip circumference	0.1	0.3	0.7	0.5	0.3	0.8	-0.4	0.4
Time employed in main current job	0.1	0.1	0.2	0.5	0.1	0.4	0.5	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.3	0.4	-0.0	0.7	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	0.3	0.1	0.8	-0.4	-0.6
Arm fat-free mass (right)	0.1	0.6	1.0	0.0	-1.0	-0.9	-0.9	-0.5
Health satisfaction	0.1	0.1	0.3	-0.0	0.1	0.5	-0.4	-0.0
Angina (self-reported)	0.1	0.1	0.3	0.1	-0.5	0.4	0.0	-0.1
Medication: Ibuprofen	0.1	0.2	0.4	0.0	-0.4	0.0	-0.5	-0.6
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.4	0.0	-0.5	-0.2	0.3
Arm predicted mass (right)	0.1	0.7	1.3	0.0	-1.1	-1.1	-0.7	-0.6
Number of full sisters	0.1	0.1	0.3	0.2	-0.4	0.0	-0.1	-0.5
Whole body fat-free mass	0.1	0.8	1.7	-0.0	-1.0	-0.9	-1.3	-0.8
Back pain experienced in last month	0.1	0.1	0.3	0.5	-0.1	0.4	0.5	0.2
Medication: Gliclazide	0.1	0.1	0.4	-0.3	-0.2	-0.6	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.8	0.5	0.0	-0.9	0.3	0.5
Whole body water mass	0.1	0.8	1.6	0.1	-1.1	-0.9	-1.3	-0.7
Hearing aid user	0.1	0.2	0.4	-0.6	-0.3	0.3	-0.5	-0.1
Basal metabolic rate	0.1	0.4	1.2	0.2	-0.7	-0.3	-1.1	-0.6
Arm fat-free mass (left)	0.1	0.8	1.8	0.0	-1.4	-0.5	-1.1	-0.6
Pain experienced in last month	0.1	0.2	0.5	-0.2	0.7	0.5	-0.4	0.4
Impedance of whole body	0.1	0.5	1.3	-0.1	0.8	1.1	0.6	-0.2
Leg fat-free mass (left)	0.0	0.1	0.3	0.3	-0.4	-0.1	-0.5	-0.3
Impedance of leg (left)	0.0	0.2	1.0	-0.3	0.2	1.0	0.1	-0.0
Leg predicted mass (left)	0.0	0.1	0.3	0.3	-0.4	-0.0	-0.6	-0.4
Father’s age at death	0.0	0.1	0.2	0.1	-0.4	-0.1	0.4	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.2	0.3	-0.2	0.1	0.5	-0.0
Leg fat-free mass (right)	0.0	0.1	0.5	0.7	-0.0	-0.1	-0.1	-0.1
Leg predicted mass (right)	0.0	0.1	0.5	0.7	-0.0	-0.0	-0.2	-0.2

Hub : Genes

ATP6V0B

Models

Trait associations