Hub : Genes

ATP8B1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Transverse 0.2230 0.0780 0.0089 0.002 NA -0.003 NA 0.002 0.260 NA 0.480 NA 0.250
2 TCGA Breast Invasive Carcinoma 0.0312 0.0143 0.0034 0.003 0.013 0.004 NA 0.004 0.057 0.00075 0.051 NA 0.049

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.4 2.2 4.1 2.0 0.5
Bipolar Disorder or Schizophrenia 0.2 0.6 0.9 1.0 -0.5
Depressed Affect (Nagel 2018) 0.0 0.0 0.1 0.1 -0.3
Depression (Nagel 2018) 0.0 0.0 0.0 -0.1 -0.2
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.4 -0.2 1.2
Neuroticism (Nagel 2018) 0.0 0.0 0.0 -0.1 -0.2
Schizophrenia (2018) 0.2 0.4 0.7 -0.4 -0.9
Schizophrenia vs Biploar Disorder 0.5 0.7 1.4 0.1 -1.2
Worry (Nagel 2018) 0.3 0.7 1.1 -1.0 -0.6
Alzheimer’s Disease (in mother) 1.1 1.3 1.7 1.0 1.3
Alzheimer’s Disease (in father) 2.7 3.0 3.3 -1.6 -1.8
Alzheimer’s Disease (including proxy) 0.1 0.2 0.3 -0.5 -0.3
Crohns Disease (2017) 0.1 0.1 0.3 -0.5 0.0
Irritable Bowel Disease (IBD) 0.1 0.3 0.6 -0.8 -0.2
Ulcerative Colitis (UC) 0.3 0.6 0.9 -0.9 -0.6
Major Depression (MDD) 0.9 1.1 2.2 -0.2 -1.5
Reaction Time 1.3 2.5 3.2 1.3 1.8
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.6 -0.7 -0.5
Breast Cancer 0.0 0.1 0.1 -0.1 0.3
Ovarian Cancer 0.4 0.5 0.8 -0.6 -0.9
Prostate Cancer 4.5 6.3 11.8 0.9 3.4
Age at First Birth 1.7 2.5 4.7 2.2 0.4
Bipolar Disorder (2011) 0.4 0.4 0.4 0.6 -0.6
Body Mass Index (BMI) (2010) 0.3 0.4 0.5 0.7 -0.6
Coronary Artery Disease (CAD) 0.4 0.5 0.6 0.7 0.7
Crohns Disease (2012) 0.8 1.2 2.4 -1.6 -0.3
Mean Putamen Volume 1.0 1.2 1.4 1.2 -1.0
Fasting Glucose 1.1 1.3 2.0 1.4 -0.8
HbA1C 0.6 0.7 1.2 -0.4 -1.1
HDL Cholesterol 1.6 2.6 4.0 2.0 1.1
LDL Cholesterol 0.0 0.0 0.0 -0.1 0.1
Lupus 0.3 0.4 0.8 -0.1 -0.9
Neuroticism (2016) 0.3 0.4 0.7 -0.9 -0.3
Primary Biliary Cirrhosis 0.1 0.1 0.1 0.3 -0.3
Rheumatoid Arthritis 1.5 2.1 4.2 -2.0 -0.1
Schizophrenia (2014) 0.1 0.2 0.3 0.5 -0.3
Triglycerides 0.1 0.2 0.3 -0.3 0.5
Type 2 Diabetes (T2D) (2012) 2.0 2.3 4.1 -0.7 -2.0
Ulcerative Colitis 0.7 1.0 2.1 -1.4 -0.1
Blood Eosinophil Count 0.1 0.8 1.6 -0.1 -1.2
Blood Platelet Count 0.2 2.5 4.9 0.2 2.2
Blood Red Count 2.0 19.5 38.8 0.4 -6.2
Blood White Count 0.5 3.5 7.0 -0.4 -2.6
Heel T-Score 0.3 2.3 3.2 -1.2 -1.8
BMI 0.4 2.4 4.9 0.1 -2.2
Height 0.0 0.1 0.1 0.3 -0.2
Waist Hip Ratio (WHR) 0.2 1.0 1.9 1.4 -0.1
Systolic Blood Pressure 0.1 0.3 0.5 0.4 0.7
Smoking Status 0.3 0.7 1.3 1.1 0.3
Allergy or Eczema 0.3 0.8 1.6 1.3 -0.1
Cardiovascular Disease 0.5 1.7 3.1 0.6 1.8
Hypothyroidism (self reported) 2.1 4.8 8.2 -1.2 -2.9
Respiratory disease 0.1 0.2 0.4 0.0 -0.6
Type 2 Diabetes (T2D) (2018) 1.1 2.0 3.6 0.6 -1.9
Lung FEV1/FVC ratio 0.2 0.9 0.9 -0.9 -1.0
Lung FVC 0.0 0.2 0.2 -0.4 0.4
Neuroticism 0.0 0.1 0.2 -0.4 -0.1
Chronotype (morning person) 0.0 0.1 0.2 0.0 0.4
Hair Pigment 0.1 1.5 3.0 -0.1 1.7
Tanning 0.1 1.2 2.4 -0.1 1.5
Hand grip strength (left) 0.3 0.7 0.9 -1.0 -0.8
Number of treatments/medications taken 0.4 0.8 1.6 -1.3 0.1
Average weekly spirits intake 2.8 3.4 3.8 -1.7 2.0
Sensitivity / hurt feelings 1.3 2.2 4.1 0.5 2.0
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.7 1.3 0.6
Hearing difficulty/problems: Yes 0.1 0.2 0.3 0.5 -0.1
Relative age of first facial hair 0.2 0.5 1.0 0.0 1.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.2 0.4 -1.1
Ever used hormone-replacement therapy (HRT) 1.8 2.3 4.7 -2.2 -0.1
Ever had hysterectomy (womb removed) 0.9 1.0 1.9 0.3 -1.4
Systolic blood pressure, automated reading 0.0 0.1 0.2 -0.0 -0.5
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 3.2 1.8 0.2
Angina 0.1 0.1 0.2 -0.1 0.4
Medication for hormone replacement therapy 0.5 0.6 1.0 -1.0 0.4
Vitamin and mineral supplements 0.2 0.3 0.3 0.6 0.5
Supplements: Zinc 0.5 0.6 0.6 0.7 0.8
Medication: Co-codamol 0.4 0.5 0.9 0.4 -0.9
Medication: Metformin 3.3 4.7 6.2 1.8 -2.5
Diabetes (father) 0.1 0.1 0.2 0.2 -0.4
Diabetes (mother) 0.3 0.3 0.4 0.4 -0.7
Severe depression (siblings) 1.1 1.2 2.4 -0.1 1.5
Pack years adult smoking proportion 0.4 0.5 0.7 -0.8 0.6
Impedance of leg (right) 0.1 0.6 1.2 -1.1 -0.0
Leg fat-free mass (left) 0.2 1.0 1.2 1.1 -0.9
Trunk fat percentage 0.4 1.6 3.3 -0.1 -1.8
Hand grip strength (right) 0.1 0.4 0.6 -0.5 -0.7
Townsend deprivation index at recruitment 0.2 0.4 0.5 0.7 0.5
Current tobacco smoking 0.2 0.3 0.6 0.3 -0.8
Average weekly fortified wine intake 0.4 0.4 0.7 -0.9 -0.3
Maternal smoking around birth 0.8 1.1 2.2 -1.5 -0.2
Fed-up feelings 0.4 0.7 1.1 1.1 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 0.9 -0.6 1.0
Relative age voice broke 0.0 0.1 0.1 0.3 0.2
Taking other prescription medications 0.4 0.7 1.0 -1.0 0.6
Age when periods started (menarche) 0.1 0.2 0.2 0.5 0.5
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 0.6 -0.6 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.4 -0.2 -0.6
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.3 0.6 -0.5
Qualifications: CSEs or equivalent 2.7 3.6 6.0 1.1 2.5
Serious illness, injury or assault to yourself 1.6 2.0 3.4 1.8 -0.7
High blood pressure 0.1 0.3 0.3 -0.5 0.5
Hayfever, allergic rhinitis or eczema 0.3 0.6 0.9 0.9 -0.5
Multivitamins +/- minerals 0.1 0.1 0.3 -0.5 -0.1
Stomach or abdominal pain in last month 0.1 0.2 0.3 0.5 0.3
Supplements: Glucosamine 0.7 0.9 1.5 1.2 -0.5
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.1 0.4 0.2
Medication: Atenolol 0.0 0.1 0.1 -0.2 0.3
Medication: Levothyroxine sodium 0.6 0.9 1.9 -1.4 -0.1
Sitting height 0.2 1.4 1.9 1.0 -1.4
Chronic bronchitis/emphysema (father) 0.7 0.8 1.3 0.6 -1.1
High blood pressure (mother) 0.1 0.2 0.3 0.6 0.2
Body mass index (BMI) 0.3 1.4 2.6 0.4 -1.6
Impedance of leg (left) 0.1 0.4 0.8 -0.9 -0.3
Leg predicted mass (left) 0.2 0.9 1.2 1.1 -0.8
Trunk fat mass 0.4 1.6 3.2 -0.2 -1.8
Waist circumference 0.8 2.8 5.4 0.4 -2.3
Number of incorrect matches in round 0.7 1.1 2.2 -1.5 -0.3
Past tobacco smoking 1.1 2.1 4.0 -0.4 -2.0
Alcohol usually taken with meals 1.1 1.8 3.1 -0.7 -1.7
Nervous feelings 0.1 0.2 0.4 0.0 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.7 0.5 0.8
Hearing difficulty/problems with background noise 0.4 0.7 1.2 1.1 -0.3
Hair/balding pattern: Pattern 2 0.5 0.6 0.7 0.9 0.7
Had menopause 0.4 0.5 0.6 -0.7 -0.8
Had other major operations 1.5 1.8 3.5 1.9 -0.3
Forced vital capacity (FVC) 0.3 1.1 2.0 0.4 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.7 0.0 -0.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 0.8 -0.9 -0.9
Qualifications: None of the above 0.2 0.4 0.9 0.9 -0.1
Financial difficulties in last 2 years 0.5 0.7 1.3 -0.0 1.2
Mouth/teeth dental problems 0.2 0.3 0.7 -0.1 0.8
Heart attack 0.2 0.3 0.6 -0.8 0.2
Allergy 0.2 0.6 1.0 -1.0 0.4
Pain all over the body in last month 0.2 0.2 0.2 0.4 0.5
Diabetes (self-reported) 1.6 2.4 4.9 0.1 -2.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.1 1.0 -0.2
Medication: Ramipril 2.5 3.2 3.2 -1.8 -1.8
Medication: Simvastatin 1.6 2.3 4.1 -2.0 0.7
Fluid intelligence score 0.4 0.9 1.3 -1.2 -0.7
Illnesses of siblings 1.4 2.0 4.1 -2.0 -0.0
Neuroticism score 0.1 0.2 0.3 0.4 0.5
Weight 0.3 1.6 2.9 0.6 -1.7
Impedance of arm (right) 0.0 0.2 0.5 -0.0 0.7
Arm fat percentage (right) 0.2 0.8 1.6 -0.3 -1.2
Trunk fat-free mass 0.1 0.3 0.7 0.8 -0.1
Hip circumference 0.5 2.3 4.4 0.4 -2.1
Time employed in main current job 2.2 2.5 3.2 1.4 1.8
Alcohol intake versus 10 years previously 0.0 0.0 0.0 -0.1 -0.0
Father’s age at death 0.5 0.6 1.2 1.1 0.1
Worrier / anxious feelings 0.3 0.6 1.1 -1.0 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 1.8 0.7 1.3
Falls in the last year 2.1 2.9 4.6 1.0 -2.1
Hair/balding pattern: Pattern 3 0.3 0.5 1.0 -1.0 -0.1
Number of live births 1.0 1.5 1.9 1.0 -1.4
Forced expiratory volume in 1-second (FEV1) 0.2 0.5 0.9 0.5 0.9
Pulse rate 0.0 0.0 0.0 0.0 -0.2
Happiness 0.5 0.6 1.0 -1.0 0.5
Noisy workplace 2.2 2.8 4.0 2.0 1.2
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.3 0.3 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.0 0.8 1.0
Mouth/teeth dental problems: Dentures 0.1 0.2 0.2 0.5 0.4
Asthma 0.5 0.9 1.8 1.4 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.2 -0.5 -0.3
Medication: Cholesterol lowering 1.5 2.3 3.8 -1.9 0.9
Depression (self-reported) 2.5 2.9 4.9 -1.0 2.2
Medication: Lansoprazole 0.4 0.5 0.9 0.3 0.9
Prospective memory result 1.0 1.3 1.6 1.3 -1.0
Lung cancer (father) 0.5 0.6 1.1 1.0 0.4
Illnesses of mother 0.6 0.8 0.8 0.9 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.7 -0.0 0.9
Pulse wave Arterial Stiffness index 0.6 0.6 0.9 0.7 0.9
Impedance of arm (left) 0.1 0.6 1.1 -0.4 1.0
Arm fat mass (right) 0.3 1.3 2.6 0.1 -1.6
Trunk predicted mass 0.1 0.3 0.6 0.8 -0.2
Standing height 0.0 0.1 0.1 0.3 -0.2
Length of working week for main job 0.0 0.0 0.0 -0.2 0.2
Exposure to tobacco smoke at home 0.2 0.3 0.5 0.2 -0.7
Breastfed as a baby 0.2 0.2 0.4 -0.2 -0.6
Tense / ‘highly strung’ 0.8 1.4 2.8 -1.7 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 3.7 -1.9 -0.3
Hair/balding pattern: Pattern 4 1.3 3.2 4.9 -1.2 -2.2
Birth weight of first child 0.4 0.8 0.9 0.9 0.9
Peak expiratory flow (PEF) 0.3 0.6 1.2 -0.2 -1.1
Pulse wave reflection index 1.9 2.4 3.2 1.3 1.8
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 0.3 -0.3
Loud music exposure frequency 0.1 0.1 0.2 -0.5 0.3
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 2.0 0.6 1.4
Mouth/teeth dental problems: Bleeding gums 3.6 4.7 9.3 -0.0 -3.1
Blood clot in the leg (DVT) 0.0 0.0 0.0 -0.0 -0.0
Medication: Paracetamol 0.4 0.7 1.4 -1.2 0.3
Headache pain in last month 0.2 0.4 0.5 -0.6 0.7
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 4.5 2.1 -0.2
Glaucoma (self-reported) 0.1 0.1 0.1 0.2 0.3
Gout (self-reported) 2.0 2.8 3.6 -1.4 1.9
Hypothyroidism/myxoedema (self-reported) 1.9 3.7 4.8 -1.6 -2.2
Medication: Amlodipine 1.0 1.4 2.6 -1.6 -0.4
Medication: Ventolin 100micrograms inhaler 0.9 1.2 2.3 1.5 -0.4
Birth weight 0.0 0.0 0.1 0.1 -0.3
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.7 -0.8 0.2
High blood pressure (siblings) 0.3 0.4 0.8 0.9 0.3
Forced vital capacity (FVC), Best measure 0.2 0.6 1.2 0.1 1.1
Body fat percentage 0.5 1.9 3.6 -0.5 -1.9
Leg fat percentage (right) 0.6 2.2 3.9 -0.8 -2.0
Arm fat-free mass (right) 0.2 1.1 1.5 0.8 -1.2
Exposure to tobacco smoke outside home 0.0 0.0 0.1 -0.2 -0.1
Comparative body size at age 10 0.3 0.7 1.3 1.1 -0.3
Number of full brothers 0.6 0.7 1.4 -0.2 1.2
Worry too long after embarrassment 0.5 0.9 1.7 -1.3 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.4 -1.5 -0.5
Wheeze or whistling in the chest in last year 0.3 0.6 1.0 0.5 1.0
Number of children fathered 1.6 1.8 3.2 -0.6 1.8
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.7 2.8 1.7 -0.7
Age at first live birth 0.6 1.0 1.2 -1.1 -0.9
Pulse wave peak to peak time 0.6 0.7 1.1 -0.6 -1.0
Health satisfaction 0.1 0.1 0.2 0.1 -0.5
Shortness of breath walking on level ground 2.7 3.2 4.7 1.3 -2.2
Qualifications: College or University degree 0.2 0.5 0.7 -0.9 -0.6
Eye problems/disorders: None of the above 1.4 1.6 3.1 -1.8 -0.3
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.6 0.3 -0.8
Emphysema/chronic bronchitis 0.7 0.7 1.4 -1.2 -0.2
Medication for pain relief, constipation, heartburn 0.9 1.6 2.9 1.7 0.5
Neck or shoulder pain in last month 0.8 1.1 1.2 1.1 1.0
Medication: Blood pressure 0.6 1.1 1.7 -1.3 -0.7
Angina (self-reported) 0.0 0.0 0.1 0.0 0.3
Migraine (self-reported) 1.6 2.0 3.1 -1.8 0.9
Medication: Ibuprofen 0.2 0.2 0.5 -0.7 -0.0
Medication: Allopurinol 1.4 1.8 2.6 -1.6 1.1
Medication: Omeprazole 0.1 0.1 0.1 -0.3 -0.1
Medication: Seretide 50 evohaler 0.2 0.3 0.3 -0.5 -0.5
Mean time to correctly identify matches 1.1 2.0 3.4 0.8 1.8
Heart disease (mother) 1.1 1.4 1.8 -1.3 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 3.6 -1.9 0.3
Whole body fat mass 0.4 1.8 3.7 -0.1 -1.9
Leg fat mass (right) 0.6 2.3 4.4 -0.5 -2.1
Arm predicted mass (right) 0.1 0.7 1.0 0.6 -1.0
Pulse rate, automated reading 0.1 0.5 0.9 0.9 -0.2
Alcohol intake frequency. 0.8 1.8 2.1 1.3 -1.4
Comparative height size at age 10 0.2 1.3 1.5 -1.1 -1.2
Number of full sisters 2.0 2.5 2.7 1.6 -1.5
Suffer from ‘nerves’ 0.2 0.3 0.6 0.1 0.8
Overall health rating 0.4 0.9 1.6 1.3 0.5
Chest pain or discomfort 0.6 0.9 1.1 0.8 -1.1
Had major operations 0.1 0.1 0.2 0.3 -0.4
Age at last live birth 0.0 0.0 0.1 -0.0 -0.3
Family relationship satisfaction 0.0 0.0 0.0 -0.2 0.0
Leg pain on walking 0.2 0.3 0.4 0.6 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.6 1.3 0.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 -0.5 -0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.5 -0.2
Medication: Aspirin 0.7 1.0 1.9 -1.4 0.3
Supplements: Vitamin C 1.0 1.2 1.8 -0.7 -1.4
Knee pain experienced in last month 0.3 0.5 0.9 -1.0 -0.1
Hypertension (Self-reported) 0.1 0.2 0.3 -0.5 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.4 0.5 1.2
Illnesses of father: Heart disease 1.9 2.7 5.2 -2.3 -0.4
Illnesses of siblings: Diabetes 0.4 0.5 0.9 1.0 0.3
Smoking status: Previous 0.6 1.0 1.9 0.1 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.0 1.0 0.0
Whole body fat-free mass 0.1 0.7 1.0 1.0 -0.7
Leg fat-free mass (right) 0.2 1.3 1.8 1.3 -0.9
Arm fat percentage (left) 0.2 0.8 1.5 -0.3 -1.2
Average weekly red wine intake 1.0 1.5 1.6 -1.2 -1.3
Handedness (chirality/laterality): Left-handed 0.6 0.7 0.8 -0.9 0.9
Mood swings 0.3 0.5 0.6 0.6 -0.8
Loneliness, isolation 0.2 0.3 0.6 0.8 0.3
Long-standing illness, disability or infirmity 0.3 0.5 0.5 0.7 -0.6
Ever had bowel cancer screening 0.8 1.0 1.4 -1.2 0.8
Diabetes diagnosed by doctor 1.3 2.1 4.2 0.1 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.5 4.2 2.0 0.9
Friendships satisfaction 1.1 1.3 2.4 -0.4 -1.6
Qualifications: nursing, teaching 0.5 0.7 1.4 1.2 0.2
Commuting to job workplace: Walk 0.4 0.4 0.9 -0.1 -0.9
Eye problems/disorders: Cataract 1.3 1.5 2.3 1.5 0.8
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 -0.5 0.3
Medication for cholesterol 1.2 1.8 2.9 0.8 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.5 0.7 -0.7
Back pain experienced in last month 0.4 0.5 0.9 0.4 1.0
Mineral and other dietary supplements 0.2 0.2 0.4 -0.7 0.1
Breast cancer (self-reported) 0.9 1.0 1.3 -1.2 -0.8
Asthma (self-reported) 0.6 1.2 2.3 1.5 0.1
Osteoporosis (self-reported) 1.0 1.2 2.3 1.5 -0.3
Osteoarthritis (self-reported) 1.4 1.8 3.7 0.0 -1.9
Medication: Aspirin 0.8 1.1 1.3 -1.2 0.9
Medication: Gliclazide 0.6 0.7 1.3 0.1 -1.1
Illnesses of father: None of the above (group 1) 0.9 1.2 1.9 0.6 -1.4
Smoking status: Current 0.3 0.5 0.6 0.6 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.3 -0.1 0.5
Whole body water mass 0.1 0.6 0.8 0.9 -0.6
Leg predicted mass (right) 0.3 1.4 2.0 1.4 -0.9
Arm fat mass (left) 0.3 1.1 2.2 0.2 -1.5
Number of self-reported non-cancer illnesses 0.1 0.2 0.5 -0.7 0.2
Average weekly champagne plus white wine intake 0.9 1.3 2.5 -1.6 -0.2
Miserableness 0.0 0.0 0.1 -0.2 0.0
Guilty feelings 0.2 0.3 0.4 0.5 -0.6
Wears glasses or contact lenses 0.0 0.0 0.1 -0.1 0.2
Ever taken oral contraceptive pill 1.1 1.3 2.3 -1.5 -0.4
Hearing aid user 0.1 0.1 0.1 -0.3 -0.2
Mother’s age at death 0.3 0.3 0.6 -0.8 0.3
Financial situation satisfaction 4.5 5.6 8.1 1.8 2.8
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 0.4 -0.1
Commuting to job workplace: Public transport 0.6 0.7 1.3 -1.1 0.2
Eye problems/disorders: Glaucoma 0.8 1.0 1.7 1.3 0.5
Medication: Blood pressure 0.9 1.7 2.0 -1.2 1.4
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.8 -0.3 -1.7
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.7 0.0 -0.8
High cholesterol (Self-reported) 2.7 4.8 9.5 -0.4 3.1
Medication: Bendroflumethiazide 0.3 0.5 1.0 -1.0 0.2
Medication: Paracetamol 0.2 0.4 0.6 -0.8 -0.4
Medication: Lisinopril 0.1 0.2 0.3 -0.6 -0.1
Medication: Atorvastatin 0.6 0.8 1.6 -1.3 0.1
Illnesses of father: High blood pressure 5.8 7.2 14.3 0.4 3.8
Alcohol drinker status: Never 0.2 0.3 0.3 -0.5 0.6
Ever smoked 1.7 3.0 5.5 0.7 2.4
Basal metabolic rate 0.1 0.8 1.0 1.0 -0.8
Leg fat percentage (left) 0.8 3.0 5.5 -0.7 -2.3
Arm fat-free mass (left) 0.1 0.7 0.9 0.7 -1.0
Number of operations (self-reported) 0.4 0.6 1.2 1.1 -0.3
Average weekly beer plus cider intake 1.3 1.9 3.1 0.9 1.8
Irritability 1.8 3.1 5.1 1.1 2.3
Risk taking 0.7 1.0 1.1 -1.1 -0.9
Ever had prostate specific antigen (PSA) test 1.4 1.6 2.1 -1.4 -1.1
Fractured/broken bones in last 5 years 0.3 0.4 0.6 -0.8 -0.4
Age started oral contraceptive pill 0.4 0.4 0.9 -0.1 -0.9
Diastolic blood pressure, automated reading 0.5 1.5 2.7 1.6 0.5
Ever depressed for a whole week 0.9 1.1 2.1 0.1 -1.5
Unable to work because of sickness or disability 1.8 2.3 3.4 1.8 1.1
Commuting to job workplace: Cycle 0.5 0.6 0.7 0.8 0.8
Myopia 0.3 0.4 0.7 -0.3 -0.8
Vascular/heart problems diagnosed by doctor 0.2 0.7 0.8 0.9 -0.7
Cholesterol lowering medication 1.5 2.3 4.5 0.1 2.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.4 -1.2 0.5
Pain experienced in last month 0.2 0.4 0.8 0.9 0.2
Supplements: Calcium 1.7 1.8 3.1 1.8 -0.8
Basal cell carcinoma (self-reported) 0.2 0.3 0.5 0.1 0.7
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.6 -0.8 0.2
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.0 0.1 0.2
Heart disease (siblings) 0.6 0.7 1.4 1.2 -0.0
Alcohol drinker status: Previous 4.6 5.3 10.1 3.2 -0.7
Pack years of smoking 0.5 0.8 0.9 -0.9 0.8
Impedance of whole body 0.1 0.5 0.7 -0.8 0.5
Leg fat mass (left) 0.6 2.4 4.7 -0.3 -2.2
Arm predicted mass (left) 0.2 1.0 1.0 1.0 -1.0