TWAS hub - ATP8B1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.2230	0.0780	0.0089	0.002	NA	-0.003	NA	0.002	0.260	NA	0.480	NA	0.250
2	TCGA	Breast Invasive Carcinoma	0.0312	0.0143	0.0034	0.003	0.013	0.004	NA	0.004	0.057	0.00075	0.051	NA	0.049

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Illnesses of father: High blood pressure	5.8	7.2	14.3	0.4	3.8
Alcohol drinker status: Previous	4.6	5.3	10.1	3.2	-0.7
Prostate Cancer	4.5	6.3	11.8	0.9	3.4
Financial situation satisfaction	4.5	5.6	8.1	1.8	2.8
Mouth/teeth dental problems: Bleeding gums	3.6	4.7	9.3	-0.0	-3.1
Medication: Metformin	3.3	4.7	6.2	1.8	-2.5
Average weekly spirits intake	2.8	3.4	3.8	-1.7	2.0
Alzheimer’s Disease (in father)	2.7	3.0	3.3	-1.6	-1.8
Qualifications: CSEs or equivalent	2.7	3.6	6.0	1.1	2.5
Shortness of breath walking on level ground	2.7	3.2	4.7	1.3	-2.2
High cholesterol (Self-reported)	2.7	4.8	9.5	-0.4	3.1
Medication: Ramipril	2.5	3.2	3.2	-1.8	-1.8
Depression (self-reported)	2.5	2.9	4.9	-1.0	2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	4.2	2.0	0.9
Time employed in main current job	2.2	2.5	3.2	1.4	1.8
Noisy workplace	2.2	2.8	4.0	2.0	1.2
Hypothyroidism (self reported)	2.1	4.8	8.2	-1.2	-2.9
Falls in the last year	2.1	2.9	4.6	1.0	-2.1
Type 2 Diabetes (T2D) (2012)	2.0	2.3	4.1	-0.7	-2.0
Blood Red Count	2.0	19.5	38.8	0.4	-6.2
Gout (self-reported)	2.0	2.8	3.6	-1.4	1.9
Number of full sisters	2.0	2.5	2.7	1.6	-1.5
Pulse wave reflection index	1.9	2.4	3.2	1.3	1.8
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	4.8	-1.6	-2.2
Illnesses of father: Heart disease	1.9	2.7	5.2	-2.3	-0.4
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.7	-2.2	-0.1
Irritability	1.8	3.1	5.1	1.1	2.3
Unable to work because of sickness or disability	1.8	2.3	3.4	1.8	1.1
Age at First Birth	1.7	2.5	4.7	2.2	0.4
Ever smoked	1.7	3.0	5.5	0.7	2.4
Supplements: Calcium	1.7	1.8	3.1	1.8	-0.8
HDL Cholesterol	1.6	2.6	4.0	2.0	1.1
Serious illness, injury or assault to yourself	1.6	2.0	3.4	1.8	-0.7
Diabetes (self-reported)	1.6	2.4	4.9	0.1	-2.2
Medication: Simvastatin	1.6	2.3	4.1	-2.0	0.7
Number of children fathered	1.6	1.8	3.2	-0.6	1.8
Migraine (self-reported)	1.6	2.0	3.1	-1.8	0.9
Rheumatoid Arthritis	1.5	2.1	4.2	-2.0	-0.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.2	1.8	0.2
Had other major operations	1.5	1.8	3.5	1.9	-0.3
Medication: Cholesterol lowering	1.5	2.3	3.8	-1.9	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.6	-1.9	0.3
Cholesterol lowering medication	1.5	2.3	4.5	0.1	2.1
Bipolar Disorder (2018)	1.4	2.2	4.1	2.0	0.5
Illnesses of siblings	1.4	2.0	4.1	-2.0	-0.0
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.5	2.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	2.8	1.7	-0.7
Eye problems/disorders: None of the above	1.4	1.6	3.1	-1.8	-0.3
Medication: Allopurinol	1.4	1.8	2.6	-1.6	1.1
Osteoarthritis (self-reported)	1.4	1.8	3.7	0.0	-1.9
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.1	-1.4	-1.1
Reaction Time	1.3	2.5	3.2	1.3	1.8
Sensitivity / hurt feelings	1.3	2.2	4.1	0.5	2.0
Hair/balding pattern: Pattern 4	1.3	3.2	4.9	-1.2	-2.2
Diabetes diagnosed by doctor	1.3	2.1	4.2	0.1	-2.0
Eye problems/disorders: Cataract	1.3	1.5	2.3	1.5	0.8
Average weekly beer plus cider intake	1.3	1.9	3.1	0.9	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	3.7	-1.9	-0.3
Medication for cholesterol	1.2	1.8	2.9	0.8	-1.7
Alzheimer’s Disease (in mother)	1.1	1.3	1.7	1.0	1.3
Fasting Glucose	1.1	1.3	2.0	1.4	-0.8
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.6	0.6	-1.9
Severe depression (siblings)	1.1	1.2	2.4	-0.1	1.5
Past tobacco smoking	1.1	2.1	4.0	-0.4	-2.0
Alcohol usually taken with meals	1.1	1.8	3.1	-0.7	-1.7
Mean time to correctly identify matches	1.1	2.0	3.4	0.8	1.8
Heart disease (mother)	1.1	1.4	1.8	-1.3	-1.0
Friendships satisfaction	1.1	1.3	2.4	-0.4	-1.6
Ever taken oral contraceptive pill	1.1	1.3	2.3	-1.5	-0.4
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.8	-0.3	-1.7
Mean Putamen Volume	1.0	1.2	1.4	1.2	-1.0
Number of live births	1.0	1.5	1.9	1.0	-1.4
Prospective memory result	1.0	1.3	1.6	1.3	-1.0
Medication: Amlodipine	1.0	1.4	2.6	-1.6	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.4	-1.5	-0.5
Supplements: Vitamin C	1.0	1.2	1.8	-0.7	-1.4
Average weekly red wine intake	1.0	1.5	1.6	-1.2	-1.3
Osteoporosis (self-reported)	1.0	1.2	2.3	1.5	-0.3
Major Depression (MDD)	0.9	1.1	2.2	-0.2	-1.5
Ever had hysterectomy (womb removed)	0.9	1.0	1.9	0.3	-1.4
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.3	1.5	-0.4
Medication for pain relief, constipation, heartburn	0.9	1.6	2.9	1.7	0.5
Breast cancer (self-reported)	0.9	1.0	1.3	-1.2	-0.8
Illnesses of father: None of the above (group 1)	0.9	1.2	1.9	0.6	-1.4
Average weekly champagne plus white wine intake	0.9	1.3	2.5	-1.6	-0.2
Medication: Blood pressure	0.9	1.7	2.0	-1.2	1.4
Ever depressed for a whole week	0.9	1.1	2.1	0.1	-1.5
Crohns Disease (2012)	0.8	1.2	2.4	-1.6	-0.3
Maternal smoking around birth	0.8	1.1	2.2	-1.5	-0.2
Waist circumference	0.8	2.8	5.4	0.4	-2.3
Tense / ‘highly strung’	0.8	1.4	2.8	-1.7	-0.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.0	0.6	1.4
Neck or shoulder pain in last month	0.8	1.1	1.2	1.1	1.0
Alcohol intake frequency.	0.8	1.8	2.1	1.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.6	1.3	0.5
Ever had bowel cancer screening	0.8	1.0	1.4	-1.2	0.8
Medication: Aspirin	0.8	1.1	1.3	-1.2	0.9
Eye problems/disorders: Glaucoma	0.8	1.0	1.7	1.3	0.5
Leg fat percentage (left)	0.8	3.0	5.5	-0.7	-2.3
Ulcerative Colitis	0.7	1.0	2.1	-1.4	-0.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.7	1.3	0.6
Supplements: Glucosamine	0.7	0.9	1.5	1.2	-0.5
Chronic bronchitis/emphysema (father)	0.7	0.8	1.3	0.6	-1.1
Number of incorrect matches in round	0.7	1.1	2.2	-1.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.8	0.7	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.0	0.8	1.0
Emphysema/chronic bronchitis	0.7	0.7	1.4	-1.2	-0.2
Medication: Aspirin	0.7	1.0	1.9	-1.4	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.4	0.5	1.2
Risk taking	0.7	1.0	1.1	-1.1	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.4	-1.2	0.5
HbA1C	0.6	0.7	1.2	-0.4	-1.1
Medication: Levothyroxine sodium	0.6	0.9	1.9	-1.4	-0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	0.8	-0.9	-0.9
Illnesses of mother	0.6	0.8	0.8	0.9	0.9
Pulse wave Arterial Stiffness index	0.6	0.6	0.9	0.7	0.9
Leg fat percentage (right)	0.6	2.2	3.9	-0.8	-2.0
Number of full brothers	0.6	0.7	1.4	-0.2	1.2
Age at first live birth	0.6	1.0	1.2	-1.1	-0.9
Pulse wave peak to peak time	0.6	0.7	1.1	-0.6	-1.0
Medication: Blood pressure	0.6	1.1	1.7	-1.3	-0.7
Leg fat mass (right)	0.6	2.3	4.4	-0.5	-2.1
Chest pain or discomfort	0.6	0.9	1.1	0.8	-1.1
Smoking status: Previous	0.6	1.0	1.9	0.1	1.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	0.8	-0.9	0.9
Asthma (self-reported)	0.6	1.2	2.3	1.5	0.1
Medication: Gliclazide	0.6	0.7	1.3	0.1	-1.1
Commuting to job workplace: Public transport	0.6	0.7	1.3	-1.1	0.2
Medication: Atorvastatin	0.6	0.8	1.6	-1.3	0.1
Heart disease (siblings)	0.6	0.7	1.4	1.2	-0.0
Leg fat mass (left)	0.6	2.4	4.7	-0.3	-2.2
Schizophrenia vs Biploar Disorder	0.5	0.7	1.4	0.1	-1.2
Blood White Count	0.5	3.5	7.0	-0.4	-2.6
Cardiovascular Disease	0.5	1.7	3.1	0.6	1.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.2	0.4	-1.1
Medication for hormone replacement therapy	0.5	0.6	1.0	-1.0	0.4
Supplements: Zinc	0.5	0.6	0.6	0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	0.9	-0.6	1.0
Hair/balding pattern: Pattern 2	0.5	0.6	0.7	0.9	0.7
Financial difficulties in last 2 years	0.5	0.7	1.3	-0.0	1.2
Hip circumference	0.5	2.3	4.4	0.4	-2.1
Father’s age at death	0.5	0.6	1.2	1.1	0.1
Happiness	0.5	0.6	1.0	-1.0	0.5
Asthma	0.5	0.9	1.8	1.4	-0.1
Lung cancer (father)	0.5	0.6	1.1	1.0	0.4
Body fat percentage	0.5	1.9	3.6	-0.5	-1.9
Worry too long after embarrassment	0.5	0.9	1.7	-1.3	-0.3
Qualifications: nursing, teaching	0.5	0.7	1.4	1.2	0.2
Diastolic blood pressure, automated reading	0.5	1.5	2.7	1.6	0.5
Commuting to job workplace: Cycle	0.5	0.6	0.7	0.8	0.8
Pack years of smoking	0.5	0.8	0.9	-0.9	0.8
Ovarian Cancer	0.4	0.5	0.8	-0.6	-0.9
Bipolar Disorder (2011)	0.4	0.4	0.4	0.6	-0.6
Coronary Artery Disease (CAD)	0.4	0.5	0.6	0.7	0.7
BMI	0.4	2.4	4.9	0.1	-2.2
Number of treatments/medications taken	0.4	0.8	1.6	-1.3	0.1
Medication: Co-codamol	0.4	0.5	0.9	0.4	-0.9
Pack years adult smoking proportion	0.4	0.5	0.7	-0.8	0.6
Trunk fat percentage	0.4	1.6	3.3	-0.1	-1.8
Average weekly fortified wine intake	0.4	0.4	0.7	-0.9	-0.3
Fed-up feelings	0.4	0.7	1.1	1.1	0.5
Taking other prescription medications	0.4	0.7	1.0	-1.0	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.6	-0.6	-0.8
Trunk fat mass	0.4	1.6	3.2	-0.2	-1.8
Hearing difficulty/problems with background noise	0.4	0.7	1.2	1.1	-0.3
Had menopause	0.4	0.5	0.6	-0.7	-0.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.1	1.0	-0.2
Fluid intelligence score	0.4	0.9	1.3	-1.2	-0.7
Medication: Lansoprazole	0.4	0.5	0.9	0.3	0.9
Birth weight of first child	0.4	0.8	0.9	0.9	0.9
Medication: Paracetamol	0.4	0.7	1.4	-1.2	0.3
Whole body fat mass	0.4	1.8	3.7	-0.1	-1.9
Overall health rating	0.4	0.9	1.6	1.3	0.5
Illnesses of siblings: Diabetes	0.4	0.5	0.9	1.0	0.3
Commuting to job workplace: Walk	0.4	0.4	0.9	-0.1	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.5	0.7	-0.7
Back pain experienced in last month	0.4	0.5	0.9	0.4	1.0
Number of operations (self-reported)	0.4	0.6	1.2	1.1	-0.3
Age started oral contraceptive pill	0.4	0.4	0.9	-0.1	-0.9
Worry (Nagel 2018)	0.3	0.7	1.1	-1.0	-0.6
Ulcerative Colitis (UC)	0.3	0.6	0.9	-0.9	-0.6
Body Mass Index (BMI) (2010)	0.3	0.4	0.5	0.7	-0.6
Lupus	0.3	0.4	0.8	-0.1	-0.9
Neuroticism (2016)	0.3	0.4	0.7	-0.9	-0.3
Heel T-Score	0.3	2.3	3.2	-1.2	-1.8
Smoking Status	0.3	0.7	1.3	1.1	0.3
Allergy or Eczema	0.3	0.8	1.6	1.3	-0.1
Hand grip strength (left)	0.3	0.7	0.9	-1.0	-0.8
Diabetes (mother)	0.3	0.3	0.4	0.4	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.3	0.6	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.9	0.9	-0.5
Body mass index (BMI)	0.3	1.4	2.6	0.4	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	0.5	0.8
Forced vital capacity (FVC)	0.3	1.1	2.0	0.4	1.4
Weight	0.3	1.6	2.9	0.6	-1.7
Worrier / anxious feelings	0.3	0.6	1.1	-1.0	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	1.0	-1.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	0.3	-1.1
Arm fat mass (right)	0.3	1.3	2.6	0.1	-1.6
Peak expiratory flow (PEF)	0.3	0.6	1.2	-0.2	-1.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	-0.8	0.2
High blood pressure (siblings)	0.3	0.4	0.8	0.9	0.3
Comparative body size at age 10	0.3	0.7	1.3	1.1	-0.3
Wheeze or whistling in the chest in last year	0.3	0.6	1.0	0.5	1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	0.3	-0.8
Knee pain experienced in last month	0.3	0.5	0.9	-1.0	-0.1
Mood swings	0.3	0.5	0.6	0.6	-0.8
Long-standing illness, disability or infirmity	0.3	0.5	0.5	0.7	-0.6
Smoking status: Current	0.3	0.5	0.6	0.6	-0.8
Leg predicted mass (right)	0.3	1.4	2.0	1.4	-0.9
Arm fat mass (left)	0.3	1.1	2.2	0.2	-1.5
Mother’s age at death	0.3	0.3	0.6	-0.8	0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.7	0.0	-0.8
Medication: Bendroflumethiazide	0.3	0.5	1.0	-1.0	0.2
Fractured/broken bones in last 5 years	0.3	0.4	0.6	-0.8	-0.4
Myopia	0.3	0.4	0.7	-0.3	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.6	0.9	1.0	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.4	-0.2	1.2
Schizophrenia (2018)	0.2	0.4	0.7	-0.4	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.6	-0.7	-0.5
Blood Platelet Count	0.2	2.5	4.9	0.2	2.2
Waist Hip Ratio (WHR)	0.2	1.0	1.9	1.4	-0.1
Lung FEV1/FVC ratio	0.2	0.9	0.9	-0.9	-1.0
Relative age of first facial hair	0.2	0.5	1.0	0.0	1.0
Vitamin and mineral supplements	0.2	0.3	0.3	0.6	0.5
Leg fat-free mass (left)	0.2	1.0	1.2	1.1	-0.9
Townsend deprivation index at recruitment	0.2	0.4	0.5	0.7	0.5
Current tobacco smoking	0.2	0.3	0.6	0.3	-0.8
Sitting height	0.2	1.4	1.9	1.0	-1.4
Leg predicted mass (left)	0.2	0.9	1.2	1.1	-0.8
Qualifications: None of the above	0.2	0.4	0.9	0.9	-0.1
Mouth/teeth dental problems	0.2	0.3	0.7	-0.1	0.8
Heart attack	0.2	0.3	0.6	-0.8	0.2
Allergy	0.2	0.6	1.0	-1.0	0.4
Pain all over the body in last month	0.2	0.2	0.2	0.4	0.5
Arm fat percentage (right)	0.2	0.8	1.6	-0.3	-1.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	0.9	0.5	0.9
Exposure to tobacco smoke at home	0.2	0.3	0.5	0.2	-0.7
Breastfed as a baby	0.2	0.2	0.4	-0.2	-0.6
Headache pain in last month	0.2	0.4	0.5	-0.6	0.7
Forced vital capacity (FVC), Best measure	0.2	0.6	1.2	0.1	1.1
Arm fat-free mass (right)	0.2	1.1	1.5	0.8	-1.2
Qualifications: College or University degree	0.2	0.5	0.7	-0.9	-0.6
Medication: Ibuprofen	0.2	0.2	0.5	-0.7	-0.0
Medication: Seretide 50 evohaler	0.2	0.3	0.3	-0.5	-0.5
Comparative height size at age 10	0.2	1.3	1.5	-1.1	-1.2
Suffer from ‘nerves’	0.2	0.3	0.6	0.1	0.8
Leg pain on walking	0.2	0.3	0.4	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	1.0	0.0
Leg fat-free mass (right)	0.2	1.3	1.8	1.3	-0.9
Arm fat percentage (left)	0.2	0.8	1.5	-0.3	-1.2
Loneliness, isolation	0.2	0.3	0.6	0.8	0.3
Mineral and other dietary supplements	0.2	0.2	0.4	-0.7	0.1
Guilty feelings	0.2	0.3	0.4	0.5	-0.6
Medication: Paracetamol	0.2	0.4	0.6	-0.8	-0.4
Alcohol drinker status: Never	0.2	0.3	0.3	-0.5	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.7	0.8	0.9	-0.7
Pain experienced in last month	0.2	0.4	0.8	0.9	0.2
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	0.1	0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	-0.8	0.2
Arm predicted mass (left)	0.2	1.0	1.0	1.0	-1.0
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.5	-0.3
Crohns Disease (2017)	0.1	0.1	0.3	-0.5	0.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	-0.8	-0.2
Primary Biliary Cirrhosis	0.1	0.1	0.1	0.3	-0.3
Schizophrenia (2014)	0.1	0.2	0.3	0.5	-0.3
Triglycerides	0.1	0.2	0.3	-0.3	0.5
Blood Eosinophil Count	0.1	0.8	1.6	-0.1	-1.2
Systolic Blood Pressure	0.1	0.3	0.5	0.4	0.7
Respiratory disease	0.1	0.2	0.4	0.0	-0.6
Hair Pigment	0.1	1.5	3.0	-0.1	1.7
Tanning	0.1	1.2	2.4	-0.1	1.5
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.5	-0.1
Angina	0.1	0.1	0.2	-0.1	0.4
Diabetes (father)	0.1	0.1	0.2	0.2	-0.4
Impedance of leg (right)	0.1	0.6	1.2	-1.1	-0.0
Hand grip strength (right)	0.1	0.4	0.6	-0.5	-0.7
Age when periods started (menarche)	0.1	0.2	0.2	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	-0.2	-0.6
High blood pressure	0.1	0.3	0.3	-0.5	0.5
Multivitamins +/- minerals	0.1	0.1	0.3	-0.5	-0.1
Stomach or abdominal pain in last month	0.1	0.2	0.3	0.5	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.4	0.2
High blood pressure (mother)	0.1	0.2	0.3	0.6	0.2
Impedance of leg (left)	0.1	0.4	0.8	-0.9	-0.3
Nervous feelings	0.1	0.2	0.4	0.0	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.0	-0.8
Neuroticism score	0.1	0.2	0.3	0.4	0.5
Trunk fat-free mass	0.1	0.3	0.7	0.8	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	0.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.2	-0.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	-0.0	0.9
Impedance of arm (left)	0.1	0.6	1.1	-0.4	1.0
Trunk predicted mass	0.1	0.3	0.6	0.8	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.3	-0.3
Loud music exposure frequency	0.1	0.1	0.2	-0.5	0.3
Glaucoma (self-reported)	0.1	0.1	0.1	0.2	0.3
Health satisfaction	0.1	0.1	0.2	0.1	-0.5
Medication: Omeprazole	0.1	0.1	0.1	-0.3	-0.1
Arm predicted mass (right)	0.1	0.7	1.0	0.6	-1.0
Pulse rate, automated reading	0.1	0.5	0.9	0.9	-0.2
Had major operations	0.1	0.1	0.2	0.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.5	-0.2
Hypertension (Self-reported)	0.1	0.2	0.3	-0.5	0.5
Whole body fat-free mass	0.1	0.7	1.0	1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	-0.1	0.5
Whole body water mass	0.1	0.6	0.8	0.9	-0.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.7	0.2
Hearing aid user	0.1	0.1	0.1	-0.3	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.4	-0.1
Medication: Lisinopril	0.1	0.2	0.3	-0.6	-0.1
Basal metabolic rate	0.1	0.8	1.0	1.0	-0.8
Arm fat-free mass (left)	0.1	0.7	0.9	0.7	-1.0
Impedance of whole body	0.1	0.5	0.7	-0.8	0.5
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	0.1	-0.3
Depression (Nagel 2018)	0.0	0.0	0.0	-0.1	-0.2
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.1	-0.2
Breast Cancer	0.0	0.1	0.1	-0.1	0.3
LDL Cholesterol	0.0	0.0	0.0	-0.1	0.1
Height	0.0	0.1	0.1	0.3	-0.2
Lung FVC	0.0	0.2	0.2	-0.4	0.4
Neuroticism	0.0	0.1	0.2	-0.4	-0.1
Chronotype (morning person)	0.0	0.1	0.2	0.0	0.4
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.0	-0.5
Relative age voice broke	0.0	0.1	0.1	0.3	0.2
Medication: Atenolol	0.0	0.1	0.1	-0.2	0.3
Impedance of arm (right)	0.0	0.2	0.5	-0.0	0.7
Alcohol intake versus 10 years previously	0.0	0.0	0.0	-0.1	-0.0
Pulse rate	0.0	0.0	0.0	0.0	-0.2
Standing height	0.0	0.1	0.1	0.3	-0.2
Length of working week for main job	0.0	0.0	0.0	-0.2	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.0	-0.0
Birth weight	0.0	0.0	0.1	0.1	-0.3
Exposure to tobacco smoke outside home	0.0	0.0	0.1	-0.2	-0.1
Angina (self-reported)	0.0	0.0	0.1	0.0	0.3
Age at last live birth	0.0	0.0	0.1	-0.0	-0.3
Family relationship satisfaction	0.0	0.0	0.0	-0.2	0.0
Miserableness	0.0	0.0	0.1	-0.2	0.0
Wears glasses or contact lenses	0.0	0.0	0.1	-0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.1	0.2

Hub : Genes

ATP8B1

Models

Trait associations