Hub : Genes

ATRN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.062	0.0220	4.6e-04	0.014	0.034	0.025	0.034	0.015	6.3e-03	4.9e-05	4.0e-04	5e-05	5.7e-03
2	GTEx	Cells Transformed fibroblasts	0.110	0.0340	3.7e-05	0.087	NA	0.088	NA	0.086	4.5e-07	NA	4.2e-07	NA	5.6e-07
3	GTEx	Skin Sun Exposed Lower leg	0.067	0.0300	8.0e-03	0.041	NA	-0.001	NA	0.027	2.3e-04	NA	3.6e-01	NA	2.5e-03
4	GTEx	Spleen	0.334	0.1040	1.0e-03	0.050	NA	0.062	NA	0.075	2.1e-02	NA	1.1e-02	NA	5.7e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.324	0.0437	0.0e+00	0.213	0.192	0.187	0.225	0.217	8.4e-27	3.7e-24	1.9e-23	2e-28	1.9e-27
6	TCGA	Testicular Germ Cell Tumors	0.097	0.0540	5.2e-03	0.040	0.057	-0.008	NA	0.034	1.5e-02	4.4e-03	8.6e-01	NA	2.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.0	3.9	-1.3	-1.2	1.5	1.6	0.4	-2.0
Bipolar Disorder or Schizophrenia	0.6	1.4	2.0	-0.9	-1.1	0.6	1.4	1.4	-1.4
Depressed Affect (Nagel 2018)	1.8	3.8	6.0	2.4	2.1	-1.7	-1.9	-0.5	2.4
Depression (Nagel 2018)	3.1	4.7	9.4	1.6	2.8	-3.1	-1.4	0.9	2.4
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.4	-1.6	0.1	-0.3	-0.2	-1.0	-0.2
Neuroticism (Nagel 2018)	4.4	10.4	16.6	3.8	3.7	-3.1	-2.9	0.0	4.1
Schizophrenia (2018)	0.3	0.6	2.2	-0.1	-0.5	-0.5	0.8	1.5	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	-0.1	-0.3	-0.2	0.4	0.8	0.3
Worry (Nagel 2018)	3.5	7.3	11.4	2.8	3.4	-2.8	-2.4	1.1	3.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	-0.7	-0.6	0.3	-0.4	-0.8	-0.4
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.6	0.2	-0.8	-0.5	0.7	-0.0
Alzheimer’s Disease (including proxy)	0.4	0.6	2.0	-1.4	-0.8	0.2	-0.2	-0.3	-0.8
Crohns Disease (2017)	0.2	0.4	0.9	-0.8	-0.5	0.3	-0.1	0.9	-0.8
Irritable Bowel Disease (IBD)	0.5	1.3	3.9	-2.0	-1.0	0.4	-0.3	1.2	-1.0
Ulcerative Colitis (UC)	0.5	0.9	2.6	-1.6	-0.7	-0.0	-0.9	1.1	-0.2
Major Depression (MDD)	1.8	2.2	5.2	2.3	1.6	-1.0	-1.7	0.2	1.3
Reaction Time	0.5	1.0	2.8	-1.7	-1.2	0.1	0.3	0.7	-1.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	0.2	-0.1	-0.7	-0.6	-0.8	0.3
Breast Cancer	0.3	0.7	2.2	1.5	0.4	-0.6	-0.8	0.2	0.8
Ovarian Cancer	1.0	1.3	5.2	-0.9	1.0	-0.1	2.3	0.8	0.2
Prostate Cancer	2.1	3.0	4.7	0.4	1.8	-1.8	-2.0	2.2	1.5
Age at First Birth	0.3	0.5	2.1	0.3	0.1	-0.7	-1.4	0.4	0.4
Bipolar Disorder (2011)	0.5	0.5	1.3	-1.1	-0.6	0.1	-1.1	-0.1	-0.3
Body Mass Index (BMI) (2010)	0.2	0.2	0.9	0.2	-0.3	0.4	0.9	-0.5	-0.3
Coronary Artery Disease (CAD)	1.8	2.2	4.5	0.7	0.8	-2.1	-1.8	1.7	1.1
Crohns Disease (2012)	0.4	0.6	3.1	-0.7	-0.1	-0.0	-0.2	1.8	-0.0
Mean Putamen Volume	0.3	0.3	0.7	-0.0	0.6	-0.7	0.9	-0.4	-0.3
Fasting Glucose	1.6	1.9	3.3	-0.5	-1.8	1.8	0.2	-1.5	-1.4
HbA1C	0.3	0.3	0.6	-0.3	0.1	-0.8	-0.5	0.8	0.5
HDL Cholesterol	0.2	0.3	1.0	-1.0	-0.4	0.6	-0.1	-0.3	-0.2
LDL Cholesterol	1.6	2.5	3.5	1.5	1.6	-1.7	-1.8	0.6	1.9
Lupus	0.2	0.3	0.8	0.6	0.3	-0.4	0.2	-0.6	0.9
Neuroticism (2016)	1.8	2.6	7.7	1.2	1.2	-1.0	-2.8	0.7	1.9
Primary Biliary Cirrhosis	3.8	5.4	10.8	-0.7	-2.8	3.3	0.8	-2.2	-2.8
Rheumatoid Arthritis	0.7	1.0	2.1	0.9	-0.9	0.4	-1.3	-1.4	-0.4
Schizophrenia (2014)	0.6	1.3	3.6	-0.6	-1.0	-0.2	1.9	1.7	-0.4
Triglycerides	1.0	1.6	4.6	1.5	1.2	-2.1	-0.1	-0.3	1.2
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.4	-0.3	-0.5	0.2	1.8	-1.8	0.1
Ulcerative Colitis	0.4	0.6	1.5	-1.1	-0.7	-0.1	0.5	1.2	0.2
Blood Eosinophil Count	0.2	1.9	4.3	1.3	2.1	-0.9	-1.7	-0.1	1.3
Blood Platelet Count	0.5	5.7	8.9	1.4	2.1	-2.0	-2.9	3.0	2.6
Blood Red Count	0.3	3.3	7.5	1.6	1.5	-2.7	-0.5	-1.5	2.4
Blood White Count	1.7	12.4	25.0	5.0	2.7	-3.6	-3.8	0.1	3.9
Heel T-Score	0.6	4.8	9.1	3.0	2.8	-1.4	0.5	2.3	2.0
BMI	0.3	1.7	2.8	-0.5	-0.9	1.5	1.6	-1.7	-1.2
Height	0.0	0.9	2.7	-1.6	-0.8	-0.6	1.1	-0.3	-0.3
Waist Hip Ratio (WHR)	0.3	1.5	2.6	0.1	0.5	-1.6	-1.5	1.4	1.3
Systolic Blood Pressure	1.0	5.2	11.0	-0.3	-2.2	3.3	2.7	-1.4	-2.5
Smoking Status	0.2	0.4	2.0	-0.1	0.4	-0.3	-0.4	1.4	-0.2
Allergy or Eczema	0.3	0.8	2.2	0.5	1.5	-0.3	-0.9	-0.1	1.3
Cardiovascular Disease	1.5	5.1	10.7	-1.1	-2.9	3.3	1.4	-1.2	-2.5
Hypothyroidism (self reported)	2.3	5.3	9.7	-2.1	-2.5	2.4	2.1	-1.0	-3.1
Respiratory disease	0.1	0.2	0.5	0.4	0.5	-0.7	-0.4	0.0	0.2
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.9	-1.2	-2.0	1.8	1.2	-0.3	-1.5
Lung FEV1/FVC ratio	0.6	3.0	10.1	1.4	3.2	-1.3	-0.2	-0.1	2.1
Lung FVC	0.2	0.9	2.2	-0.8	1.5	-0.8	-0.7	1.1	0.2
Neuroticism	2.5	6.0	10.1	3.2	2.9	-1.9	-1.9	0.5	3.2
Chronotype (morning person)	0.5	1.2	2.0	0.9	1.3	-0.8	-1.4	-0.9	1.2
Hair Pigment	0.0	0.4	1.1	-0.9	-0.3	-0.1	0.0	1.1	0.6
Tanning	1.4	17.3	25.1	-4.8	-4.9	5.0	2.9	-1.0	-4.7
Hand grip strength (left)	0.3	0.9	3.3	0.0	0.0	-1.8	-0.0	1.3	0.5
Number of treatments/medications taken	0.6	1.1	2.6	-0.8	-1.1	1.6	-0.1	-0.2	-1.4
Average weekly spirits intake	0.9	1.2	4.7	-0.8	0.8	0.5	-0.8	2.2	-0.3
Sensitivity / hurt feelings	1.2	2.0	4.2	1.8	1.3	-0.7	-1.6	0.0	2.1
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.8	1.3	1.9	-1.9	-0.5	-0.5	1.6
Hearing difficulty/problems: Yes	1.3	2.0	6.7	-1.2	-0.7	2.6	1.0	0.1	-1.5
Relative age of first facial hair	0.3	0.5	1.2	-0.3	0.9	0.2	1.0	1.1	-0.1
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	3.4	-1.7	-1.3	1.8	1.6	0.1	-1.9
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.9	0.2	0.5	0.7	0.3	-2.0	-0.1
Ever had hysterectomy (womb removed)	0.1	0.2	0.5	0.3	0.2	0.1	0.3	-0.7	0.4
Systolic blood pressure, automated reading	0.6	1.8	4.3	-0.1	-1.5	1.6	2.1	-1.1	-0.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.4	-1.2	-1.6	1.3	0.8	0.7	-1.1
Angina	0.6	0.7	1.8	0.2	-0.9	0.8	0.0	1.1	-1.4
Medication for hormone replacement therapy	0.2	0.3	0.9	-0.3	0.2	0.1	0.9	0.6	-0.5
Vitamin and mineral supplements	1.4	1.9	3.0	0.9	-0.8	1.7	1.7	-1.7	-1.2
Supplements: Zinc	1.1	1.2	2.5	-1.6	-1.0	0.9	0.3	-0.8	-1.6
Medication: Co-codamol	1.7	2.0	2.9	-1.6	-1.4	1.3	1.4	0.8	-1.7
Medication: Metformin	0.5	0.7	1.7	-0.1	-1.3	0.8	0.6	-0.3	-1.2
Diabetes (father)	0.6	0.7	2.6	1.6	0.1	-0.1	0.2	-1.1	0.4
Diabetes (mother)	0.6	0.8	1.9	1.2	-0.6	0.3	0.8	-1.4	-0.5
Severe depression (siblings)	0.3	0.3	0.4	0.3	-0.6	0.5	0.6	-0.5	-0.6
Pack years adult smoking proportion	0.5	0.7	1.4	1.0	0.6	-0.1	-1.2	-1.2	0.0
Impedance of leg (right)	3.6	17.5	24.5	3.7	3.8	-4.6	-4.4	3.4	5.0
Leg fat-free mass (left)	2.0	10.4	14.3	-2.9	-3.1	3.2	3.8	-2.9	-3.4
Trunk fat percentage	0.5	2.1	5.1	2.3	1.5	-0.6	-1.4	-0.3	1.6
Hand grip strength (right)	0.3	0.9	3.5	-0.3	-0.0	-1.9	0.1	1.2	0.5
Townsend deprivation index at recruitment	0.5	0.7	2.6	-0.4	-0.2	-1.1	-1.6	0.5	-0.2
Current tobacco smoking	0.1	0.2	0.6	0.2	-0.2	0.2	-0.5	-0.6	-0.8
Average weekly fortified wine intake	0.6	0.7	2.3	-0.6	0.0	-0.8	-0.9	1.5	0.5
Maternal smoking around birth	0.5	0.7	1.2	0.7	0.8	-0.5	-1.1	-0.8	1.0
Fed-up feelings	2.6	4.8	7.3	2.4	1.8	-2.2	-2.7	-1.0	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	4.4	1.2	1.8	-2.1	-1.2	0.4	1.6
Relative age voice broke	1.6	2.5	5.4	-1.2	-0.8	2.3	2.3	0.4	-1.4
Taking other prescription medications	2.7	4.1	8.5	-1.0	-1.8	2.9	0.9	-1.6	-2.9
Age when periods started (menarche)	0.2	0.5	1.1	-0.8	-0.3	1.0	0.6	-1.0	-0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.8	-0.2	0.3	0.9	0.4	-1.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	6.8	2.6	1.5	-1.7	0.3	0.5	1.7
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	4.6	0.2	0.7	-2.1	-2.0	2.0	1.0
Qualifications: CSEs or equivalent	1.4	1.9	3.9	0.0	-0.1	2.0	1.7	-1.9	-0.9
Serious illness, injury or assault to yourself	0.9	1.1	2.9	-1.7	-1.2	0.8	0.5	0.2	-1.2
High blood pressure	1.0	2.7	7.5	-0.3	-1.4	2.7	1.7	-1.0	-1.8
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.6	1.0	1.3	-0.8	-0.5	0.0	1.6
Multivitamins +/- minerals	1.3	1.6	2.7	-0.0	1.3	-1.4	-1.6	0.9	1.6
Stomach or abdominal pain in last month	0.5	0.7	1.5	0.7	0.5	-0.6	-1.2	0.8	0.8
Supplements: Glucosamine	0.5	0.6	1.9	-1.4	1.0	0.7	0.0	0.6	-0.1
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.9	-0.2	1.3	-1.5	-0.3	2.2	1.4
Medication: Atenolol	0.2	0.3	1.1	1.1	0.5	-0.3	-0.3	-0.0	-0.2
Medication: Levothyroxine sodium	1.0	1.8	4.2	-0.9	-1.4	1.5	1.0	-0.6	-2.0
Sitting height	0.1	0.8	2.1	-0.6	-1.0	0.2	0.8	-1.4	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.5	1.0	1.0	0.2	0.9	0.6	-0.4	0.5
High blood pressure (mother)	2.9	4.0	6.5	-1.4	-2.6	2.2	0.7	-2.2	-2.3
Body mass index (BMI)	0.4	1.5	2.9	0.1	-0.8	1.6	1.2	-1.7	-1.2
Impedance of leg (left)	4.1	19.8	28.7	4.1	4.2	-4.7	-4.5	3.5	5.4
Leg predicted mass (left)	2.0	10.6	14.6	-2.9	-3.1	3.2	3.8	-3.0	-3.5
Trunk fat mass	0.1	0.6	1.7	1.3	0.5	0.1	-0.3	-1.0	0.6
Waist circumference	0.1	0.5	1.2	0.3	-0.5	0.9	0.4	-1.1	-0.4
Number of incorrect matches in round	0.3	0.5	1.6	-1.1	0.0	-0.2	-0.1	1.3	0.1
Past tobacco smoking	0.3	0.6	1.9	-0.5	-0.4	-0.5	-0.5	-1.4	0.7
Alcohol usually taken with meals	0.4	0.6	1.8	-1.0	0.1	0.6	0.8	1.4	-0.2
Nervous feelings	3.7	6.9	10.5	3.1	3.2	-2.8	-1.3	1.9	2.8
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	4.8	1.7	2.2	-1.4	-1.3	0.4	1.1
Hearing difficulty/problems with background noise	0.8	1.2	3.0	0.2	-0.9	1.5	0.7	-0.8	-1.7
Hair/balding pattern: Pattern 2	0.2	0.3	1.1	0.3	0.2	-0.5	1.0	-0.4	-0.2
Had menopause	0.8	1.0	1.5	-0.1	1.0	-0.8	-1.2	1.2	0.9
Had other major operations	0.5	0.6	1.8	0.3	0.9	-0.4	0.5	1.4	0.5
Forced vital capacity (FVC)	0.2	0.6	2.0	-0.6	0.7	-1.4	-0.3	-0.0	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.8	2.2	1.2	-1.4	0.3	0.3	1.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.8	1.5	0.5	-0.7	-0.4	-1.7	0.4
Qualifications: None of the above	1.1	2.3	4.1	0.2	2.0	-1.5	-1.2	1.9	1.5
Financial difficulties in last 2 years	0.8	1.1	1.5	-0.9	-1.2	1.0	1.2	0.7	-1.1
Mouth/teeth dental problems	0.7	1.0	2.8	0.4	0.6	-1.7	-0.8	0.0	1.5
Heart attack	1.7	2.2	6.2	1.6	1.3	-0.6	-2.5	1.5	0.7
Allergy	0.4	0.8	2.4	-0.8	-0.9	1.0	-0.2	-0.5	-1.5
Pain all over the body in last month	1.1	1.2	3.3	-1.1	-0.7	1.8	1.0	0.8	-0.8
Diabetes (self-reported)	0.9	1.4	3.3	-0.2	-1.4	1.8	1.1	-0.8	-1.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	0.7	-0.4	0.3	0.9	-0.1	0.2
Medication: Ramipril	0.6	0.7	2.5	-0.4	-0.6	0.8	0.9	0.1	-1.6
Medication: Simvastatin	0.2	0.4	1.0	-0.2	0.0	0.8	-0.3	1.0	-0.6
Fluid intelligence score	0.3	0.5	1.1	0.9	0.4	-0.6	-1.1	0.4	0.7
Illnesses of siblings	0.5	0.7	1.6	0.4	0.1	-0.9	-1.3	-0.4	1.2
Neuroticism score	1.9	4.1	7.1	2.7	2.2	-1.4	-1.8	0.1	2.6
Weight	0.4	1.8	3.5	-0.5	-1.2	1.3	1.6	-1.9	-1.2
Impedance of arm (right)	1.2	5.4	10.1	1.8	2.1	-2.4	-3.2	1.0	2.8
Arm fat percentage (right)	0.2	0.8	2.5	0.9	-0.0	1.1	-0.2	-1.6	-0.4
Trunk fat-free mass	1.5	8.5	10.8	-3.0	-3.0	2.6	3.3	-2.3	-3.2
Hip circumference	0.6	2.6	5.3	-0.3	-1.4	2.1	1.3	-2.3	-1.5
Time employed in main current job	3.7	4.2	6.9	0.7	1.6	-2.0	-2.5	2.6	2.3
Alcohol intake versus 10 years previously	1.5	2.2	6.1	0.4	1.2	-1.6	-2.5	1.6	0.8
Father’s age at death	0.3	0.4	1.1	0.5	-0.7	0.3	-0.1	-1.1	-0.6
Worrier / anxious feelings	2.9	5.4	8.5	1.4	2.6	-2.5	-2.8	1.1	2.9
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.1	0.2	0.2	0.4	0.2	-0.4
Falls in the last year	0.5	0.7	3.1	-1.8	-0.4	0.3	-0.0	0.3	-0.9
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	0.8	0.6	-0.4	-1.3	1.2	0.6
Number of live births	0.5	0.7	2.1	-0.1	-0.5	0.8	-0.0	-1.4	-1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.6	-0.1	1.9	-1.8	-0.5	0.5	1.8
Pulse rate	0.5	0.8	3.1	0.3	-1.0	0.6	-0.3	-1.8	-0.2
Happiness	1.2	1.5	4.0	0.4	1.2	-2.0	-1.1	-0.2	1.4
Noisy workplace	1.2	1.5	3.6	-0.7	-1.0	1.9	0.8	-0.9	-1.5
Qualifications: A levels/AS levels or equivalent	1.7	3.7	5.5	-1.4	-1.7	2.3	2.2	-1.8	-2.0
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.1	-1.3	-0.9	0.9	0.6	1.5	-1.4
Mouth/teeth dental problems: Dentures	0.9	1.4	3.4	-0.3	-1.7	1.8	1.0	-0.5	-1.0
Asthma	0.2	0.4	0.7	-0.1	-0.4	0.8	0.9	-0.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	0.1	0.2	-0.1	-0.7	0.5	0.7
Medication: Cholesterol lowering	0.5	0.7	2.5	-0.1	0.6	-0.5	-1.6	1.0	-0.0
Depression (self-reported)	0.6	0.8	1.1	1.1	1.0	-0.9	-0.9	-0.8	0.4
Medication: Lansoprazole	0.3	0.3	0.8	0.4	-0.4	0.7	0.2	-0.9	-0.5
Prospective memory result	0.3	0.4	0.8	0.7	0.1	0.3	-0.8	0.9	0.7
Lung cancer (father)	1.7	1.9	3.6	1.5	1.6	-0.7	-1.9	1.0	1.2
Illnesses of mother	1.7	2.1	4.1	1.7	2.0	-1.4	-0.4	0.9	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.4	-0.6	1.2	-1.6	-0.1	-0.1	1.4
Pulse wave Arterial Stiffness index	0.6	0.7	1.7	0.2	0.0	-1.1	-1.3	0.1	1.0
Impedance of arm (left)	1.6	7.4	12.2	2.7	2.5	-2.8	-3.5	0.9	3.1
Arm fat mass (right)	0.2	0.8	2.5	0.4	-0.3	1.2	0.5	-1.6	-0.7
Trunk predicted mass	1.5	8.5	10.6	-3.0	-3.0	2.6	3.3	-2.4	-3.1
Standing height	0.0	0.5	1.2	-1.1	-0.6	-0.7	0.4	-0.7	0.1
Length of working week for main job	0.4	0.5	1.1	-0.8	-0.1	0.5	1.1	0.5	-0.7
Exposure to tobacco smoke at home	1.4	1.5	7.6	-0.5	-0.7	0.9	-0.1	-2.8	-0.4
Breastfed as a baby	0.4	0.5	2.9	-1.7	0.4	-0.1	0.1	0.0	0.1
Tense / ‘highly strung’	0.7	1.1	2.0	1.4	1.4	-0.7	-0.7	0.6	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.8	1.5	1.7	-1.3	-0.8	0.0	0.8
Hair/balding pattern: Pattern 4	0.2	0.6	1.5	-0.3	-0.4	1.1	1.2	-0.3	-0.4
Birth weight of first child	1.2	2.2	7.6	0.3	0.9	-1.8	-2.8	0.7	0.9
Peak expiratory flow (PEF)	2.0	4.7	8.4	0.8	2.9	-2.3	-1.1	2.3	2.7
Pulse wave reflection index	1.2	1.4	4.3	0.3	1.1	-2.1	-0.6	0.9	1.4
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.5	-0.5	-1.3	1.9	1.7	-0.4	-1.2
Loud music exposure frequency	1.4	1.5	2.8	-1.2	-0.8	0.9	1.7	-1.1	-1.4
Qualifications: O levels/GCSEs or equivalent	3.2	5.2	8.9	-2.5	-3.0	2.3	1.5	-1.5	-2.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.8	0.2	-0.0	-0.1	-0.6	0.4	-0.9
Blood clot in the leg (DVT)	1.3	1.7	4.7	1.5	0.9	-2.2	-1.0	-0.5	1.1
Medication: Paracetamol	0.2	0.3	1.0	-0.7	-0.1	-0.3	-1.0	0.6	0.3
Headache pain in last month	0.3	0.6	1.4	-0.8	0.1	1.0	-0.5	1.2	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.2	0.3	0.8	-1.0	1.0	-0.3	1.1
Glaucoma (self-reported)	0.7	0.8	2.9	-1.7	-0.8	0.0	-0.3	0.9	-0.8
Gout (self-reported)	0.3	0.4	0.9	0.5	0.7	-0.8	-0.6	-0.2	0.9
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	6.8	-1.4	-1.8	2.2	1.1	-0.7	-2.6
Medication: Amlodipine	2.8	4.0	9.6	-0.8	-2.0	3.1	1.9	0.6	-2.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.4	-0.1	0.6	0.9	0.1	1.2	-0.4
Birth weight	0.3	0.6	2.8	0.8	0.1	-0.0	0.3	-1.7	-0.1
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.6	-1.3	-0.4	0.7	-0.5	-0.3	-0.2
High blood pressure (siblings)	2.0	2.8	6.4	-1.9	-1.7	1.4	1.3	0.4	-2.5
Forced vital capacity (FVC), Best measure	0.2	0.6	2.5	-1.6	0.1	-1.1	0.3	-0.1	0.2
Body fat percentage	0.4	1.7	5.2	2.3	1.3	-0.5	-1.1	-0.2	1.4
Leg fat percentage (right)	0.3	1.1	3.8	2.0	1.0	-0.6	-0.5	0.1	1.1
Arm fat-free mass (right)	1.1	5.5	9.0	-2.1	-2.4	2.3	3.0	-1.6	-2.4
Exposure to tobacco smoke outside home	0.9	1.3	3.9	-0.4	-1.5	0.6	0.3	-2.0	-0.9
Comparative body size at age 10	1.1	3.0	9.0	-0.3	-2.1	0.8	1.1	-3.0	-1.6
Number of full brothers	2.4	3.1	5.7	-2.0	-2.0	1.9	0.8	-0.4	-2.4
Worry too long after embarrassment	3.9	6.6	11.0	3.2	3.3	-1.7	-2.8	-0.4	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.3	-0.3	-0.4	0.7	0.6	-0.4
Wheeze or whistling in the chest in last year	0.2	0.4	2.1	-0.2	0.2	-0.1	-1.5	0.3	-0.5
Number of children fathered	0.4	0.4	2.2	1.5	0.1	0.3	0.2	0.4	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.1	0.1	-1.6	1.8	1.5	-1.6	-1.3
Age at first live birth	0.7	1.2	2.4	-1.4	-1.6	0.7	1.1	0.8	-0.7
Pulse wave peak to peak time	0.4	0.5	1.6	0.1	0.3	0.8	1.3	-0.2	-0.7
Health satisfaction	0.7	0.9	1.6	-1.1	-1.2	0.2	0.7	-0.7	-1.3
Shortness of breath walking on level ground	0.4	0.5	2.1	0.5	0.0	-0.1	-1.4	-0.4	0.6
Qualifications: College or University degree	0.3	1.1	3.3	0.6	0.1	0.4	1.6	-1.8	0.2
Eye problems/disorders: None of the above	1.6	1.9	4.8	0.9	1.7	-2.2	-0.2	-0.0	1.6
Mouth/teeth dental problems: Loose teeth	1.4	1.7	4.5	-0.6	-1.3	1.2	1.4	-0.2	-2.1
Emphysema/chronic bronchitis	0.5	0.5	1.2	-0.8	-0.6	0.8	0.2	1.1	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.2	3.8	0.1	-0.5	0.8	1.9	-1.5	-0.5
Neck or shoulder pain in last month	0.7	0.9	1.4	-0.1	1.1	-1.2	-0.9	1.1	0.9
Medication: Blood pressure	0.2	0.4	1.3	0.4	0.1	0.8	-1.1	0.7	-0.2
Angina (self-reported)	0.6	0.8	2.2	-0.0	-0.9	0.8	0.0	1.1	-1.5
Migraine (self-reported)	0.3	0.4	0.9	-0.1	-0.9	0.7	-0.9	0.1	-0.4
Medication: Ibuprofen	0.1	0.1	0.3	-0.3	-0.3	0.5	0.2	0.3	-0.0
Medication: Allopurinol	1.5	2.0	3.3	1.6	1.4	-1.6	-1.2	-0.1	1.8
Medication: Omeprazole	0.2	0.3	0.9	-0.6	-0.9	-0.3	0.1	0.3	-0.5
Medication: Seretide 50 evohaler	0.3	0.4	0.9	-0.8	0.2	0.6	0.6	0.9	0.0
Mean time to correctly identify matches	0.4	0.7	2.2	-1.2	-0.2	-0.3	-0.1	1.5	-0.7
Heart disease (mother)	0.3	0.4	1.5	-1.2	-0.0	0.5	0.3	0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	5.6	1.5	2.1	-2.2	-2.1	2.1	2.4
Whole body fat mass	0.1	0.4	1.2	1.1	0.4	0.4	0.0	-1.0	0.3
Leg fat mass (right)	0.1	0.2	0.6	0.8	0.1	0.5	0.5	-0.6	-0.1
Arm predicted mass (right)	1.1	5.7	8.4	-1.9	-2.4	2.3	2.9	-2.2	-2.5
Pulse rate, automated reading	0.9	2.8	5.8	-2.4	-1.8	1.9	1.3	0.5	-1.6
Alcohol intake frequency.	0.2	0.5	1.3	-1.1	-0.4	0.8	-0.0	0.5	-0.8
Comparative height size at age 10	0.1	0.5	1.2	-0.2	-0.0	-1.1	-0.5	-1.0	0.6
Number of full sisters	0.7	0.9	4.2	0.1	-0.6	-0.5	0.6	-2.0	-0.4
Suffer from ‘nerves’	3.2	5.0	9.5	2.9	3.1	-2.3	-0.8	1.3	2.1
Overall health rating	0.2	0.4	0.9	-0.1	-0.5	0.9	0.1	0.5	-1.0
Chest pain or discomfort	0.3	0.4	1.0	0.6	-0.2	-0.2	-0.8	1.0	-0.6
Had major operations	0.3	0.4	1.3	-0.7	0.0	0.5	-0.4	1.1	-0.2
Age at last live birth	0.8	1.1	4.7	-0.7	-2.2	0.2	0.2	-0.2	-1.1
Family relationship satisfaction	0.9	1.1	4.7	-0.5	-1.0	-0.6	0.4	-2.2	-0.4
Leg pain on walking	0.6	0.7	1.8	-0.5	0.6	0.5	1.4	1.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.5	-0.8	0.1	-1.0	-0.7	-0.8
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.2	0.1	-0.9	1.4	1.8	-1.4	-1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.2	1.5	0.6	0.1	0.3	-0.7	0.4
Medication: Aspirin	2.5	3.3	8.2	0.8	0.7	-1.8	-2.5	2.9	1.0
Supplements: Vitamin C	0.5	0.6	2.1	-0.9	-0.6	-0.5	-0.3	1.4	-0.3
Knee pain experienced in last month	0.4	0.6	1.1	0.8	1.1	-0.7	-1.0	0.5	-0.2
Hypertension (Self-reported)	1.0	2.8	8.0	-0.4	-1.5	2.8	1.3	-1.0	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.4	4.0	7.7	-2.3	-2.3	2.2	1.0	0.5	-2.8
Illnesses of father: Heart disease	0.8	1.2	6.0	-0.4	0.8	-0.2	0.0	2.4	0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.7	0.9	0.7	-0.1	-0.3	0.5	0.3
Smoking status: Previous	0.4	0.6	3.0	-0.3	0.1	0.4	0.4	1.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	-0.6	0.3	-0.4	0.9	-0.9	0.4
Whole body fat-free mass	1.7	9.6	12.8	-2.9	-3.1	2.9	3.6	-2.8	-3.3
Leg fat-free mass (right)	2.1	11.5	15.0	-3.1	-3.3	3.3	3.9	-3.0	-3.6
Arm fat percentage (left)	0.2	0.9	2.6	1.3	0.1	0.9	-0.1	-1.6	-0.2
Average weekly red wine intake	0.2	0.3	1.5	-0.4	-0.4	0.4	-0.0	-1.2	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.6	-0.6	0.2	-0.3	0.7	-0.1
Mood swings	2.0	3.6	7.2	2.7	1.4	-0.7	-1.5	-2.6	1.8
Loneliness, isolation	2.0	2.8	4.4	1.6	1.7	-2.1	-1.2	0.8	2.1
Long-standing illness, disability or infirmity	0.3	0.5	1.1	0.1	0.3	0.8	0.6	1.1	-0.8
Ever had bowel cancer screening	2.1	2.5	4.7	1.2	2.2	-1.6	-1.7	-0.4	1.9
Diabetes diagnosed by doctor	1.0	1.7	3.8	-0.6	-1.5	1.9	0.9	-0.9	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.8	-0.0	-1.9	1.4	1.5	-1.2	-1.4
Friendships satisfaction	1.2	1.5	8.4	-0.0	0.5	-0.5	-0.6	-2.9	0.0
Qualifications: nursing, teaching	0.5	0.8	2.5	0.3	-0.9	1.0	0.1	-1.6	-0.7
Commuting to job workplace: Walk	0.8	0.8	1.9	-1.4	-0.7	0.0	-0.5	1.1	-1.1
Eye problems/disorders: Cataract	1.7	2.0	4.8	-0.4	-2.0	2.2	0.1	-0.2	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.5	-1.3	-0.4	1.6	0.7	-1.2	-1.1
Medication for cholesterol	2.5	3.8	10.1	0.3	1.1	-2.5	-3.2	0.2	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.3	4.7	-2.2	-1.2	1.3	1.6	-0.8	-1.7
Back pain experienced in last month	0.3	0.5	1.0	-0.6	0.1	-0.7	1.0	1.0	0.4
Mineral and other dietary supplements	1.6	2.1	5.2	0.7	-1.9	1.1	2.3	-0.8	-1.2
Breast cancer (self-reported)	0.2	0.2	0.9	0.4	-0.5	-0.0	0.2	-0.9	0.0
Asthma (self-reported)	0.1	0.2	0.4	0.2	-0.0	0.5	0.6	-0.1	-0.6
Osteoporosis (self-reported)	0.8	1.0	5.4	-0.3	0.6	-0.4	0.3	2.3	0.3
Osteoarthritis (self-reported)	0.8	1.0	2.3	1.3	0.8	-0.7	0.3	1.5	0.8
Medication: Aspirin	3.2	4.2	11.0	0.8	1.2	-2.0	-2.5	3.3	1.3
Medication: Gliclazide	0.2	0.2	0.7	-0.3	-0.2	0.8	0.4	-0.3	-0.4
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.2	-0.1	-0.5	-0.0	-0.3	0.2
Smoking status: Current	0.1	0.2	0.5	0.3	-0.0	0.2	-0.3	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	4.3	0.4	2.1	-1.5	-0.8	-0.2	1.3
Whole body water mass	1.8	10.0	12.4	-3.0	-3.2	3.0	3.5	-2.8	-3.4
Leg predicted mass (right)	2.1	11.3	14.8	-3.0	-3.2	3.4	3.9	-3.0	-3.6
Arm fat mass (left)	0.2	0.7	1.8	0.3	-0.3	1.2	0.7	-1.3	-0.7
Number of self-reported non-cancer illnesses	0.8	1.4	4.3	-0.1	-1.0	1.5	0.9	0.0	-2.1
Average weekly champagne plus white wine intake	3.2	4.4	6.8	-2.2	-2.2	2.3	2.6	-0.7	-2.1
Miserableness	0.2	0.3	1.1	0.2	0.0	0.8	0.1	-1.1	-0.0
Guilty feelings	2.1	3.2	5.2	1.8	1.8	-1.5	-2.3	0.1	2.3
Wears glasses or contact lenses	1.2	1.4	3.0	1.7	0.3	-0.6	-1.6	0.2	1.6
Ever taken oral contraceptive pill	0.3	0.4	1.6	0.1	0.3	-0.4	-1.3	-0.6	0.3
Hearing aid user	2.4	2.7	6.8	-1.6	-0.6	2.6	1.5	0.6	-1.9
Mother’s age at death	1.6	2.0	4.2	1.8	1.2	-2.1	-0.9	-0.1	1.5
Financial situation satisfaction	1.3	1.6	4.7	-1.3	-0.7	0.7	0.7	-2.2	-1.4
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.5	0.5	1.6	-0.2	-0.3	1.2	1.2
Commuting to job workplace: Public transport	0.5	0.6	1.3	-0.5	1.2	-0.4	-0.9	0.9	0.7
Eye problems/disorders: Glaucoma	1.1	1.3	4.2	-2.1	-0.6	-0.1	-0.6	1.5	-0.6
Medication: Blood pressure	1.8	3.4	6.7	-0.3	-1.5	2.6	2.3	-1.1	-2.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.1	-1.3	0.4	-0.5	0.4	1.7	-0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.2	5.2	-0.2	1.2	-0.1	-2.3	-0.0	0.8
High cholesterol (Self-reported)	0.7	1.2	3.7	1.0	0.4	-0.8	-1.9	1.1	0.6
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.3	-0.0	0.6	0.7	0.2	-0.2
Medication: Paracetamol	0.3	0.5	1.6	-0.8	-0.3	-0.5	-0.4	1.3	0.2
Medication: Lisinopril	0.4	0.5	1.2	1.1	0.2	-0.7	-0.3	-0.4	1.1
Medication: Atorvastatin	0.4	0.5	1.5	0.2	-0.8	-0.6	-0.6	-1.2	-0.3
Illnesses of father: High blood pressure	1.5	1.9	4.1	0.3	-1.2	2.0	-0.2	-1.8	-1.6
Alcohol drinker status: Never	5.4	6.5	12.0	-2.3	-3.5	2.1	2.7	-1.1	-2.9
Ever smoked	0.2	0.3	0.6	0.8	0.5	0.2	-0.4	0.3	-0.7
Basal metabolic rate	1.4	7.8	10.3	-2.4	-2.8	2.8	3.2	-2.6	-3.0
Leg fat percentage (left)	0.4	1.5	4.8	2.2	1.3	-0.6	-0.6	0.2	1.4
Arm fat-free mass (left)	0.9	4.7	6.2	-1.9	-2.1	2.0	2.5	-2.2	-2.2
Number of operations (self-reported)	0.4	0.6	1.4	0.3	0.7	-0.8	-1.2	0.9	0.5
Average weekly beer plus cider intake	2.9	4.2	9.3	3.1	2.0	-2.1	-1.7	-0.5	2.0
Irritability	0.6	1.0	2.3	1.5	0.9	-0.4	0.9	-0.2	1.4
Risk taking	0.6	0.9	2.0	-0.3	-1.4	1.2	0.8	-0.7	-0.9
Ever had prostate specific antigen (PSA) test	2.7	3.2	5.3	-1.6	-1.9	2.3	1.4	0.4	-2.3
Fractured/broken bones in last 5 years	3.0	3.9	6.7	-1.7	-2.2	1.5	2.0	-1.6	-2.6
Age started oral contraceptive pill	7.3	9.2	17.1	1.7	2.7	-3.5	-3.7	1.1	4.1
Diastolic blood pressure, automated reading	0.5	1.7	3.8	-0.5	-1.1	1.7	0.9	-2.0	-0.9
Ever depressed for a whole week	0.8	1.0	1.9	1.4	0.8	-1.4	-0.6	-0.4	0.9
Unable to work because of sickness or disability	0.1	0.2	0.5	-0.7	-0.4	0.0	-0.1	0.5	-0.3
Commuting to job workplace: Cycle	2.1	2.5	3.8	-1.8	-1.9	1.7	1.4	-0.6	-1.7
Myopia	0.2	0.3	1.3	1.1	0.3	-0.3	0.4	-0.3	0.2
Vascular/heart problems diagnosed by doctor	0.7	2.0	6.4	-0.1	1.1	-2.5	-0.9	0.9	1.7
Cholesterol lowering medication	0.8	1.1	2.8	-0.4	-1.2	1.7	0.5	0.1	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.6	-0.9	-1.3	-0.1	-0.2	0.1	-0.9
Pain experienced in last month	0.2	0.3	1.2	0.4	-0.5	-0.2	0.3	-1.1	0.0
Supplements: Calcium	0.9	1.0	2.4	-1.5	0.4	-0.9	-0.6	1.5	-0.2
Basal cell carcinoma (self-reported)	0.1	0.2	0.7	-0.1	0.3	0.1	-0.2	-0.8	-0.1
Heart attack/myocardial infarction (self-reported)	1.9	2.4	6.5	1.6	1.3	-0.7	-2.5	1.6	0.8
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.9	1.6	0.9	-2.0	-0.8	-0.5	1.2
Heart disease (siblings)	1.4	1.8	5.3	0.1	-0.1	2.1	2.3	0.5	-0.9
Alcohol drinker status: Previous	0.3	0.3	1.1	0.7	0.1	0.4	-0.2	-1.0	-0.2
Pack years of smoking	0.5	0.7	2.0	1.0	0.9	-0.4	-1.4	-0.4	0.4
Impedance of whole body	3.2	16.3	23.7	3.8	3.9	-4.2	-4.5	2.5	4.9
Leg fat mass (left)	0.1	0.3	0.8	0.9	0.2	0.4	0.5	-0.7	0.1
Arm predicted mass (left)	1.1	5.7	9.0	-2.2	-2.4	2.3	3.0	-1.9	-2.5