TWAS hub - ATXN2L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0600	0.0330	1.3e-03	0.021	NA	0.015	NA	0.019	7.5e-03	NA	2.1e-02	NA	9.7e-03
2	METSIM	Adipose	0.0553	0.0235	1.6e-07	0.068	0.05	0.060	0.052	0.064	1.9e-10	5e-08	2.2e-09	3e-08	6.2e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Trunk fat percentage	35.2	140.9	171.6	-10.5	-13.1
Arm fat percentage (right)	34.8	137.0	163.8	-10.5	-12.8
Trunk fat mass	34.7	148.9	176.9	-11.0	-13.3
Arm fat percentage (left)	34.2	136.2	166.4	-10.3	-12.9
Waist circumference	32.9	120.2	146.4	-9.7	-12.1
Hip circumference	31.8	137.0	163.8	-10.5	-12.8
Whole body fat mass	31.7	132.4	158.8	-10.3	-12.6
Arm fat mass (left)	31.4	128.9	153.8	-10.2	-12.4
Arm fat mass (right)	31.3	128.7	151.3	-10.3	-12.3
Body fat percentage	30.9	121.9	148.8	-9.7	-12.2
Alcohol intake frequency.	27.6	64.2	74.2	-7.4	-8.6
Weight	25.0	122.8	141.6	-10.2	-11.9
Leg fat mass (left)	24.4	95.3	114.5	-8.7	-10.7
BMI	23.4	135.8	161.3	-10.5	-12.7
Leg fat mass (right)	23.4	90.7	108.2	-8.6	-10.4
Intelligence (Savage-Jansen 2018)	21.8	66.9	83.7	7.1	9.2
Body mass index (BMI)	20.9	89.0	107.5	-8.4	-10.4
Body Mass Index (BMI) (2010)	20.4	28.0	35.7	-4.5	-6.0
Comparative body size at age 10	18.7	51.6	58.7	-6.7	-7.7
Crohns Disease (2012)	17.0	27.3	28.7	-5.1	-5.4
Leg fat percentage (left)	17.0	61.6	78.1	-6.7	-8.8
Leg predicted mass (left)	16.6	88.2	99.4	-8.8	-10.0
Leg fat-free mass (left)	16.3	86.5	97.2	-8.7	-9.9
Leg fat-free mass (right)	15.7	84.0	94.1	-8.6	-9.7
Leg predicted mass (right)	15.7	83.9	94.1	-8.6	-9.7
Crohns Disease (2017)	15.4	33.8	40.1	-5.2	-6.3
Leg fat percentage (right)	15.4	55.9	69.8	-6.5	-8.4
Irritable Bowel Disease (IBD)	14.6	34.8	40.2	-5.4	-6.3
Verbal and Numeric Reasoning (VNR)	14.6	35.1	41.7	5.3	6.5
Qualifications: College or University degree	13.3	41.9	50.7	5.8	7.1
Qualifications: None of the above	12.2	26.1	33.5	-4.3	-5.8
Fluid intelligence score	11.8	24.4	30.1	4.3	5.5
Basal metabolic rate	11.7	65.0	71.6	-7.6	-8.5
Suffer from ‘nerves’	11.1	17.4	18.6	-4.0	-4.3
Number of live births	10.8	15.2	22.1	4.7	2.9
Handedness (chirality/laterality): Left-handed	10.7	12.9	14.3	-3.4	-3.8
Allergy or Eczema	10.5	27.7	31.0	5.6	4.9
Serious illness, injury or assault of a close relative in last 2 years	7.9	9.1	9.4	3.0	3.1
Comparative height size at age 10	7.7	42.2	45.4	-6.7	-6.2
Whole body fat-free mass	7.7	43.8	47.2	-6.4	-6.9
Whole body water mass	7.4	42.1	45.3	-6.2	-6.7
Hayfever, allergic rhinitis or eczema	6.9	14.9	14.9	3.9	3.9
Alcohol usually taken with meals	6.7	10.9	13.9	2.8	3.7
Alcohol drinker status: Never	6.7	8.0	8.4	-2.8	-2.9
Ever taken oral contraceptive pill	6.3	7.1	7.5	2.7	2.6
Eye problems/disorders: None of the above	6.2	7.2	9.2	-3.0	-2.3
Medication: Paracetamol	6.1	9.4	10.9	-2.8	-3.3
Hayfever/allergic rhinitis (self-reported)	6.0	7.9	9.1	3.0	2.6
Arm fat-free mass (left)	6.0	30.3	33.5	-5.2	-5.8
Arm predicted mass (left)	5.9	30.1	34.2	-5.1	-5.8
Blood Red Count	5.8	56.2	74.6	6.1	8.6
Birth weight of first child	5.8	10.6	13.1	-3.6	-2.8
Mean Putamen Volume	5.7	6.5	7.9	2.8	2.2
Impedance of leg (right)	5.7	27.5	31.6	4.8	5.6
Hand grip strength (right)	5.4	14.6	22.5	2.6	4.7
Pulse wave peak to peak time	5.4	6.3	6.4	-2.5	-2.5
Breastfed as a baby	5.3	6.6	8.5	2.2	2.9
Impedance of leg (left)	5.2	25.3	28.3	4.7	5.3
Pack years adult smoking proportion	5.1	7.8	10.6	-2.2	-3.3
Arm fat-free mass (right)	5.1	26.2	29.8	-4.8	-5.5
Fed-up feelings	5.0	9.1	12.6	-2.4	-3.5
Arm predicted mass (right)	5.0	25.6	28.4	-4.8	-5.3
Average weekly champagne plus white wine intake	4.9	6.7	6.9	2.6	2.6
Rheumatoid Arthritis	4.8	6.6	9.2	-2.0	-3.0
Ulcerative Colitis (UC)	4.7	8.9	10.7	-2.7	-3.3
Miserableness	4.7	8.2	9.3	-2.7	-3.0
Supplements: Calcium	4.5	5.0	5.4	2.2	2.3
Qualifications: A levels/AS levels or equivalent	4.4	9.8	13.2	2.5	3.6
Medication: Co-codamol	4.2	4.9	7.0	-1.7	-2.7
Medication: Paracetamol	4.2	7.0	8.9	-2.3	-3.0
Number of children fathered	4.2	4.7	5.0	2.2	2.1
Ulcerative Colitis	4.1	6.0	6.1	-2.5	-2.4
Cardiovascular Disease	4.1	13.5	18.9	-2.8	-4.3
Medication: Metformin	4.1	5.7	7.8	-1.9	-2.8
Average weekly red wine intake	4.0	5.9	8.4	1.8	2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.0	8.4	12.4	2.1	3.5
Ever smoked	3.9	6.8	8.0	2.4	2.8
Happiness	3.8	4.6	6.0	1.8	2.4
Birth weight	3.8	8.2	9.9	-2.6	-3.1
Pack years of smoking	3.8	5.6	7.4	-1.9	-2.7
Type 2 Diabetes (T2D) (2018)	3.7	6.8	11.5	-1.5	-3.4
Illnesses of siblings: Diabetes	3.7	4.6	6.4	-1.7	-2.5
Pulse wave Arterial Stiffness index	3.6	4.2	4.2	2.1	2.0
Myopia	3.6	5.2	5.9	2.1	2.4
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	5.4	1.7	2.3
Age when periods started (menarche)	3.4	8.1	8.8	2.7	3.0
Allergy	3.4	7.9	8.5	-2.7	-2.9
Trunk fat-free mass	3.4	19.4	19.5	-4.4	-4.4
Lung cancer (father)	3.3	3.9	4.9	-2.2	-1.7
Trunk predicted mass	3.3	19.0	19.1	-4.3	-4.4
Hypertension (Self-reported)	3.3	9.1	12.7	-2.3	-3.6
Diabetes (self-reported)	3.2	4.9	7.9	-1.4	-2.8
Loneliness, isolation	3.2	4.4	5.4	-2.3	-1.8
Qualifications: CSEs or equivalent	3.1	4.1	6.4	-1.3	-2.5
Heart disease (mother)	3.1	3.8	5.5	2.3	1.4
Mean time to correctly identify matches	3.0	5.8	8.6	2.9	1.7
Friendships satisfaction	3.0	3.7	4.1	2.0	1.8
Medication: Gliclazide	3.0	3.4	4.6	-1.5	-2.2
Risk taking	3.0	4.4	7.7	1.0	2.8
Alcohol intake versus 10 years previously	2.9	4.3	5.4	-1.8	-2.3
Mouth/teeth dental problems: Loose teeth	2.9	3.5	6.2	-0.9	-2.5
Eye problems/disorders: Cataract	2.9	3.3	3.5	1.9	1.8
Eye problems/disorders: Glaucoma	2.9	3.4	3.8	2.0	1.7
Bipolar Disorder (2018)	2.8	4.5	5.8	-1.8	-2.4
Hypothyroidism (self reported)	2.8	6.4	8.8	-2.0	-3.0
High blood pressure	2.8	7.8	10.7	-2.2	-3.3
Hair/balding pattern: Pattern 4	2.8	6.8	9.1	3.0	2.1
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.8	7.8	-2.8	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	4.7	-2.2	-1.4
Medication: Amlodipine	2.7	3.8	5.3	-1.5	-2.3
Alcohol drinker status: Previous	2.7	3.1	4.2	-1.4	-2.0
Medication: Blood pressure	2.5	4.4	7.8	-1.0	-2.8
Overall health rating	2.5	5.3	9.4	-1.1	-3.1
Commuting to job workplace: Car/motor vehicle	2.5	2.9	3.1	-1.6	-1.8
Commuting to job workplace: Public transport	2.5	2.9	3.5	1.5	1.9
HDL Cholesterol	2.4	3.9	7.6	0.5	2.8
Long-standing illness, disability or infirmity	2.4	3.6	6.6	-0.8	-2.6
Respiratory disease	2.3	5.1	6.7	2.6	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	4.4	-1.3	-2.1
Standing height	2.3	23.2	25.3	-5.0	-4.6
Diabetes diagnosed by doctor	2.3	3.7	7.0	-0.6	-2.7
Depressed Affect (Nagel 2018)	2.2	4.7	6.2	-1.8	-2.5
Lung FVC	2.2	11.4	20.2	1.6	4.5
Gout (self-reported)	2.2	3.0	3.7	-1.9	-1.5
Qualifications: nursing, teaching	2.2	3.4	3.5	1.9	1.8
Vascular/heart problems diagnosed by doctor	2.2	6.1	8.5	1.9	2.9
Bipolar Disorder or Schizophrenia	2.1	5.1	5.8	-2.4	-2.1
Ever had hysterectomy (womb removed)	2.1	2.4	4.1	2.0	0.8
Multivitamins +/- minerals	2.1	2.7	3.6	1.3	1.9
Blood Platelet Count	2.0	22.9	45.8	6.8	0.2
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	4.0	1.6	2.0
Unable to work because of sickness or disability	2.0	2.6	3.1	-1.8	-1.5
Mouth/teeth dental problems	1.9	2.9	2.9	1.7	1.7
Pulse rate	1.9	3.2	4.5	2.1	1.3
Pulse wave reflection index	1.9	2.3	3.4	1.1	1.9
Medication: Aspirin	1.9	2.5	4.1	2.0	0.9
Smoking status: Current	1.9	3.1	4.3	-1.3	-2.1
Medication for hormone replacement therapy	1.8	2.1	2.3	1.5	1.3
Current tobacco smoking	1.8	3.0	4.3	-1.3	-2.1
Hearing difficulty/problems with background noise	1.8	2.8	3.6	1.9	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	4.3	-1.2	-2.1
Exposure to tobacco smoke outside home	1.8	2.4	2.6	-1.6	-1.4
Smoking status: Previous	1.8	2.6	4.9	0.6	2.2
Diastolic blood pressure, automated reading	1.8	5.5	6.5	-2.1	-2.6
Father’s age at death	1.7	2.3	3.0	1.7	1.3
Mouth/teeth dental problems: Dentures	1.7	2.9	3.8	-2.0	-1.4
Prospective memory result	1.7	2.1	2.5	-1.6	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	2.2	-1.5	-1.4
Mood swings	1.7	3.0	5.5	-0.7	-2.4
Medication: Atorvastatin	1.7	2.1	3.1	1.8	1.1
Ever depressed for a whole week	1.7	2.1	3.3	0.9	1.8
Angina	1.6	2.2	2.8	1.2	1.7
Medication: Lisinopril	1.6	2.1	2.7	-1.2	-1.6
Reaction Time	1.5	2.9	4.7	2.2	1.0
HbA1C	1.5	1.7	1.9	-1.2	-1.4
Number of treatments/medications taken	1.5	2.8	5.2	-0.6	-2.3
Medication: Ramipril	1.5	1.9	3.3	-0.7	-1.8
Emphysema/chronic bronchitis	1.5	1.7	2.4	-1.6	-1.0
Systolic blood pressure, automated reading	1.4	4.1	4.3	-2.1	-2.0
Past tobacco smoking	1.4	2.5	4.1	-0.9	-2.0
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	2.2	1.5	1.5
Impedance of arm (right)	1.4	6.6	7.5	-2.4	-2.7
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.5	-1.1	-1.6
Number of full sisters	1.4	1.7	2.5	1.6	0.9
Medication: Aspirin	1.4	1.8	3.3	1.8	0.5
Medication: Bendroflumethiazide	1.4	2.1	4.1	-0.4	-2.0
LDL Cholesterol	1.3	2.0	2.0	1.4	1.4
Chronotype (morning person)	1.3	3.0	5.5	-0.8	-2.4
Ever used hormone-replacement therapy (HRT)	1.3	1.7	1.8	1.2	1.4
Supplements: Zinc	1.3	1.5	1.7	1.3	1.1
Heart attack	1.3	1.6	2.2	-1.0	-1.5
Impedance of arm (left)	1.3	6.1	8.4	-2.0	-2.9
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	3.5	-1.2	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.8	0.6	2.0
Hand grip strength (left)	1.2	3.2	5.9	0.7	2.4
Townsend deprivation index at recruitment	1.2	1.7	1.8	-1.3	-1.3
Glaucoma (self-reported)	1.2	1.4	1.9	1.4	0.9
Worry too long after embarrassment	1.2	1.9	2.4	1.5	1.2
Wheeze or whistling in the chest in last year	1.2	2.2	2.8	-1.3	-1.7
Angina (self-reported)	1.2	1.6	2.1	1.1	1.4
Family relationship satisfaction	1.2	1.5	2.7	0.6	1.6
Number of self-reported non-cancer illnesses	1.2	2.0	3.8	-0.5	-1.9
Height	1.1	22.0	23.9	-4.9	-4.5
Number of full brothers	1.1	1.4	2.3	1.5	0.7
Ever had bowel cancer screening	1.1	1.3	1.4	1.2	1.1
Neuroticism (Nagel 2018)	1.0	2.3	2.5	-1.4	-1.6
Nervous feelings	1.0	1.9	3.1	-0.9	-1.8
Asthma	1.0	1.9	2.0	1.4	1.3
Headache pain in last month	1.0	1.8	1.9	-1.4	-1.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.2	-0.2	1.8
Migraine (self-reported)	1.0	1.2	1.3	1.1	1.1
Heart attack/myocardial infarction (self-reported)	1.0	1.3	1.9	-0.8	-1.4
Worry (Nagel 2018)	0.9	1.9	2.7	-1.7	-1.0
Illnesses of siblings	0.9	1.3	2.3	0.6	1.5
Medication: Lansoprazole	0.9	1.0	1.3	-1.1	-0.9
Age at first live birth	0.9	1.7	2.8	-1.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.0	-0.2	1.4
Asthma (self-reported)	0.9	1.8	2.0	1.3	1.4
Average weekly beer plus cider intake	0.9	1.3	1.4	-1.2	-1.2
Fractured/broken bones in last 5 years	0.9	1.1	1.1	-1.0	-1.1
Schizophrenia (2018)	0.8	1.7	2.7	-1.6	-0.8
Relative age of first facial hair	0.8	1.7	2.4	1.5	1.1
Relative age voice broke	0.8	1.2	1.7	0.9	1.3
Stomach or abdominal pain in last month	0.8	1.0	1.8	0.4	1.4
Medication: Levothyroxine sodium	0.8	1.3	2.4	-0.4	-1.5
Medication: Simvastatin	0.8	1.2	2.4	0.1	-1.6
Illnesses of mother	0.8	1.0	1.4	-1.2	-0.7
Exposure to tobacco smoke at home	0.8	0.9	1.2	1.1	-0.8
Neck or shoulder pain in last month	0.8	1.2	1.3	1.0	1.1
Supplements: Vitamin C	0.8	1.0	1.0	-1.0	-1.0
Osteoporosis (self-reported)	0.8	1.0	1.0	1.0	1.0
Cholesterol lowering medication	0.8	1.1	1.9	1.4	0.6
Heel T-Score	0.7	5.2	5.4	2.3	2.2
Diabetes (father)	0.7	0.8	1.4	0.5	-1.2
High blood pressure (mother)	0.7	1.0	1.1	1.0	-1.1
Pain all over the body in last month	0.7	0.7	1.4	-1.2	-0.1
Peak expiratory flow (PEF)	0.7	1.7	2.9	-1.7	-0.7
Medication for pain relief, constipation, heartburn	0.7	1.3	2.3	0.5	1.5
Commuting to job workplace: Walk	0.7	0.8	1.3	1.1	0.5
Medication: Blood pressure	0.7	1.4	2.4	-0.5	-1.6
Alzheimer’s Disease (in father)	0.6	0.7	1.3	0.2	1.1
Schizophrenia (2014)	0.6	1.4	2.0	-0.9	-1.4
Waist Hip Ratio (WHR)	0.6	2.8	3.4	-1.5	-1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	0.8	0.9	0.9
Neuroticism score	0.6	1.4	1.5	-1.1	-1.2
Loud music exposure frequency	0.6	0.6	1.2	-1.1	-0.1
Medication for cholesterol	0.6	0.9	1.7	-1.3	-0.1
Illnesses of father: High blood pressure	0.6	0.8	1.5	1.2	0.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.4	-1.2	0.1
Schizophrenia vs Biploar Disorder	0.5	0.7	1.0	0.6	1.0
Alzheimer’s Disease (including proxy)	0.5	0.8	1.5	0.2	1.2
Blood Eosinophil Count	0.5	3.5	5.3	-1.3	-2.3
Sensitivity / hurt feelings	0.5	0.9	1.1	-1.1	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	1.9	-0.7	-1.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.9	0.4	-1.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	-0.1	-1.1
Had other major operations	0.5	0.6	0.9	-0.5	-1.0
Shortness of breath walking on level ground	0.5	0.6	0.6	-0.8	-0.8
Medication: Allopurinol	0.5	0.7	1.2	-0.4	-1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.9	-0.9	-0.6
Knee pain experienced in last month	0.5	0.8	1.5	0.4	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.5	0.7	0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.3	0.0	1.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	0.4	1.0
Neuroticism (2016)	0.4	0.5	0.9	-0.4	-1.0
Lung FEV1/FVC ratio	0.4	1.8	2.1	1.5	1.3
Maternal smoking around birth	0.4	0.6	0.7	0.7	0.8
Serious illness, injury or assault to yourself	0.4	0.5	0.7	0.8	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	0.4	-0.9
Sitting height	0.4	2.5	5.0	-2.2	-0.3
Worrier / anxious feelings	0.4	0.8	1.3	-1.2	-0.5
Medication: Cholesterol lowering	0.4	0.6	1.3	0.1	-1.1
Depression (self-reported)	0.4	0.4	0.4	-0.7	-0.7
Medication: Ibuprofen	0.4	0.5	1.0	1.0	0.0
Chest pain or discomfort	0.4	0.6	0.7	-0.7	-0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.4	0.6	0.8	-0.6
Fasting Glucose	0.3	0.4	0.5	-0.5	-0.7
Lupus	0.3	0.4	0.5	-0.6	-0.7
Blood White Count	0.3	2.1	3.7	0.7	-1.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.8	-0.1
Diabetes (mother)	0.3	0.4	0.5	-0.7	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	0.5	-0.8
Medication: Atenolol	0.3	0.4	0.5	0.5	-0.7
Forced vital capacity (FVC)	0.3	1.3	2.6	-1.6	0.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.3	-0.8	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.5	-0.7	1.2
Tense / ‘highly strung’	0.3	0.5	0.9	-0.4	0.9
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.3	0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.4	-0.5	0.6
High blood pressure (siblings)	0.3	0.4	0.4	0.6	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.3	2.4	-1.6	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.0	0.8
Medication: Omeprazole	0.3	0.4	0.5	-0.7	0.5
Pulse rate, automated reading	0.3	1.1	1.3	1.1	-0.9
Age at last live birth	0.3	0.4	0.7	-0.8	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.3	0.6	-0.8	0.3
Wears glasses or contact lenses	0.3	0.4	0.7	0.8	0.1
Number of operations (self-reported)	0.3	0.5	0.6	0.8	0.7
Age started oral contraceptive pill	0.3	0.4	0.7	0.8	0.4
Heart disease (siblings)	0.3	0.3	0.4	0.6	0.5
Impedance of whole body	0.3	1.3	1.5	1.2	1.1
Depression (Nagel 2018)	0.2	0.3	0.5	-0.3	-0.7
Ovarian Cancer	0.2	0.3	0.5	0.2	0.7
Primary Biliary Cirrhosis	0.2	0.2	0.3	0.5	0.4
Hair Pigment	0.2	4.4	6.8	2.6	1.4
Average weekly spirits intake	0.2	0.3	0.5	0.3	0.7
Vitamin and mineral supplements	0.2	0.2	0.5	0.1	-0.7
Taking other prescription medications	0.2	0.3	0.4	0.4	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	0.6	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	-0.7	-0.1
Health satisfaction	0.2	0.3	0.4	0.7	0.4
Medication: Seretide 50 evohaler	0.2	0.3	0.4	0.6	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.2	0.5	-0.5
Had major operations	0.2	0.2	0.3	0.6	0.3
Mineral and other dietary supplements	0.2	0.3	0.4	0.5	-0.6
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.4	-0.7
Mother’s age at death	0.2	0.3	0.5	0.0	0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.7	-0.0
Irritability	0.2	0.3	0.6	0.2	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.1	0.7
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.2	0.3
Prostate Cancer	0.1	0.1	0.1	-0.4	0.2
Triglycerides	0.1	0.1	0.2	-0.2	-0.5
Systolic Blood Pressure	0.1	0.4	0.8	-0.9	0.1
Smoking Status	0.1	0.1	0.2	-0.5	0.0
Neuroticism	0.1	0.1	0.2	-0.3	-0.5
Tanning	0.1	0.9	1.8	0.0	1.3
Hearing difficulty/problems: Yes	0.1	0.2	0.2	0.4	-0.4
Severe depression (siblings)	0.1	0.1	0.1	-0.2	-0.3
Number of incorrect matches in round	0.1	0.1	0.2	-0.5	-0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.3	0.3
Had menopause	0.1	0.1	0.2	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	-0.4	-0.7
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.4	-0.2
Time employed in main current job	0.1	0.1	0.1	0.3	0.3
Falls in the last year	0.1	0.2	0.3	0.5	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	-0.1	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	-0.4	-0.2
Leg pain on walking	0.1	0.1	0.1	-0.2	0.3
Back pain experienced in last month	0.1	0.1	0.1	-0.3	-0.4
Breast cancer (self-reported)	0.1	0.1	0.1	-0.4	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.3	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.5	0.3
Major Depression (MDD)	0.0	0.1	0.1	0.1	0.3
Breast Cancer	0.0	0.0	0.0	-0.0	0.1
Age at First Birth	0.0	0.0	0.0	0.0	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.3	-0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.2	0.0
Average weekly fortified wine intake	0.0	0.0	0.1	-0.1	-0.2
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	-0.0
Noisy workplace	0.0	0.0	0.1	-0.0	-0.3
Length of working week for main job	0.0	0.0	0.1	0.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.3	0.2
Illnesses of father: Heart disease	0.0	0.1	0.1	-0.1	0.3
Guilty feelings	0.0	0.0	0.0	0.2	-0.2
Hearing aid user	0.0	0.0	0.0	-0.1	0.1
Financial situation satisfaction	0.0	0.1	0.1	0.3	0.0
High cholesterol (Self-reported)	0.0	0.1	0.1	-0.0	-0.3
Pain experienced in last month	0.0	0.0	0.0	-0.0	0.1

Hub : Genes

ATXN2L

Models

Trait associations