Hub : Genes

B4GALT5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0550	0.0240	4.4e-03	0.033	0.022	0.055	0.032	0.052	6.4e-05	9.9e-04	3.0e-07	7.0e-05	5.2e-07
2	GTEx	Cells Transformed fibroblasts	0.1080	0.0410	2.3e-03	0.023	NA	0.023	NA	0.025	7.1e-03	NA	7.1e-03	NA	4.9e-03
3	GTEx	Muscle Skeletal	0.0767	0.0312	4.7e-03	-0.002	NA	0.004	NA	0.001	6.6e-01	NA	1.2e-01	NA	2.4e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.1994	0.0357	6.7e-16	0.109	0.141	0.146	0.156	0.154	8.3e-14	9.9e-18	2.4e-18	1.6e-19	3.0e-19
5	YFS	Blood	0.0343	0.0135	1.8e-03	0.007	0.012	0.007	0.012	0.010	1.6e-03	6.9e-05	1.5e-03	4.1e-05	2.2e-04
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0233	0.0143	6.9e-03	0.006	0.000	-0.001	NA	0.000	7.0e-02	3.2e-01	5.1e-01	NA	3.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.9	1.4	5.7	0.1	-0.4	0.8	0.9	2.4	-1.1
Bipolar Disorder or Schizophrenia	1.5	3.7	15.5	-1.0	0.3	2.2	0.6	3.9	-0.6
Depressed Affect (Nagel 2018)	0.6	1.2	3.7	0.8	-0.7	1.1	-0.0	1.9	-1.2
Depression (Nagel 2018)	0.9	1.4	3.1	0.1	-1.1	1.8	-1.2	0.9	-1.4
Intelligence (Savage-Jansen 2018)	0.6	1.9	5.3	2.0	-0.1	-2.3	-0.4	-1.0	-0.9
Neuroticism (Nagel 2018)	0.5	1.1	3.1	0.7	0.3	1.7	-0.4	1.8	-0.2
Schizophrenia (2018)	1.4	2.9	9.8	-1.5	0.6	2.2	0.0	3.1	0.1
Schizophrenia vs Biploar Disorder	0.9	1.2	4.2	-2.0	0.4	-0.9	0.4	1.2	0.6
Worry (Nagel 2018)	1.0	2.1	7.1	1.3	1.0	2.7	0.3	1.5	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.2	0.4	0.8	0.1	0.0	0.5
Alzheimer’s Disease (in father)	0.8	0.9	2.8	-0.9	0.2	1.0	0.7	1.7	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	5.1	-0.2	-0.2	2.3	-0.1	0.6	-0.2
Crohns Disease (2017)	0.4	0.9	2.2	-1.2	0.7	1.5	-0.4	0.9	-0.0
Irritable Bowel Disease (IBD)	0.5	1.1	2.3	-0.7	1.4	0.5	1.4	1.5	0.3
Ulcerative Colitis (UC)	1.2	2.3	7.0	-0.6	1.6	-0.4	2.6	1.8	0.7
Major Depression (MDD)	1.3	1.6	3.3	1.6	-1.4	1.8	-0.6	1.2	-0.4
Reaction Time	0.3	0.6	1.4	0.6	0.0	1.0	-0.8	1.2	-0.6
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.3	2.5	0.4	-1.9	-0.0	-0.4	-1.1
Breast Cancer	0.8	2.0	6.7	-1.0	2.6	0.5	0.4	-0.8	1.9
Ovarian Cancer	0.5	0.7	4.1	0.2	0.1	2.0	0.1	-0.2	0.4
Prostate Cancer	0.5	0.7	2.4	0.3	-1.5	-0.5	0.4	0.3	-1.2
Age at First Birth	0.1	0.2	0.4	0.6	-0.3	0.5	-0.4	-0.3	0.0
Bipolar Disorder (2011)	1.5	1.5	4.6	-0.9	1.1	2.1	0.6	1.3	0.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.6	0.5	-0.6	-1.1	-0.0	-1.3	-1.2
Coronary Artery Disease (CAD)	0.5	0.6	1.7	1.3	0.5	-0.3	-0.4	-0.7	-1.1
Crohns Disease (2012)	0.5	0.8	3.8	0.4	0.4	2.0	-0.6	-0.0	-0.6
Mean Putamen Volume	6.6	7.5	12.2	3.5	-3.2	-1.2	-2.5	-2.2	-3.2
Fasting Glucose	1.0	1.2	4.0	1.4	0.1	-0.7	-0.4	-0.5	-2.0
HbA1C	0.5	0.6	2.0	-0.6	0.3	0.1	1.4	1.0	0.4
HDL Cholesterol	0.1	0.2	0.5	0.3	0.5	0.1	0.7	0.0	0.6
LDL Cholesterol	0.6	1.0	3.0	1.7	-1.1	-1.0	-0.5	-0.1	-0.6
Lupus	0.2	0.3	0.8	-0.1	0.1	-0.5	0.9	-0.9	0.5
Neuroticism (2016)	0.9	1.3	3.5	-1.9	-0.0	-0.6	0.6	1.8	-0.1
Primary Biliary Cirrhosis	2.0	2.9	8.9	-1.7	3.0	0.6	0.7	-0.7	2.0
Rheumatoid Arthritis	1.4	1.9	6.6	2.6	-1.6	0.4	-0.6	-0.1	-1.3
Schizophrenia (2014)	1.9	4.1	13.4	-1.8	1.2	2.4	0.2	3.7	0.7
Triglycerides	0.9	1.5	2.9	-1.1	-1.4	0.7	-1.7	1.2	-1.1
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.9	1.4	-1.3	0.1	-0.6	-0.2	-2.0
Ulcerative Colitis	1.9	2.8	6.6	-0.4	1.6	1.2	2.6	2.2	1.1
Blood Eosinophil Count	0.2	1.3	4.1	-0.1	1.8	2.0	0.4	-0.2	0.8
Blood Platelet Count	0.2	2.0	6.5	1.0	-1.2	2.5	0.2	1.8	0.4
Blood Red Count	0.7	6.5	11.6	2.8	-1.4	-3.3	-1.9	-1.8	-3.4
Blood White Count	0.1	0.5	1.2	-0.0	-0.8	0.6	1.1	0.0	-0.7
Heel T-Score	0.4	2.9	6.9	0.8	1.9	-2.2	-0.2	-2.6	1.4
BMI	1.2	6.7	16.1	1.8	-3.3	-2.4	-2.0	-0.9	-4.0
Height	0.3	5.2	15.2	-2.0	1.7	1.0	3.9	1.8	2.1
Waist Hip Ratio (WHR)	0.2	0.8	1.8	-0.2	-1.3	0.9	-0.1	0.7	-1.3
Systolic Blood Pressure	1.6	7.9	17.3	-2.9	4.2	-0.2	1.8	-1.1	4.1
Smoking Status	0.7	1.8	5.7	-1.3	0.2	2.4	-0.2	1.7	-0.4
Allergy or Eczema	3.1	8.2	13.0	-1.7	3.2	1.7	3.6	3.6	2.7
Cardiovascular Disease	0.3	1.1	2.9	0.1	-1.3	1.3	0.3	1.7	-0.5
Hypothyroidism (self reported)	0.4	0.9	2.5	-0.7	-1.6	-1.1	0.1	1.2	-0.2
Respiratory disease	1.0	2.3	7.7	-0.4	-0.9	2.8	1.0	2.0	-0.5
Type 2 Diabetes (T2D) (2018)	2.7	5.0	13.1	2.5	-3.6	-0.3	-0.9	-0.8	-3.0
Lung FEV1/FVC ratio	3.9	19.6	40.5	6.4	-3.6	-3.0	-3.7	-3.3	-5.5
Lung FVC	0.7	3.6	8.7	-2.9	0.2	-0.5	1.5	3.0	1.4
Neuroticism	0.7	1.6	5.7	0.7	0.3	1.8	0.1	2.4	0.1
Chronotype (morning person)	0.2	0.5	1.0	-0.8	-0.3	-0.9	1.0	0.6	0.3
Hair Pigment	0.1	3.2	8.6	-1.1	1.2	-0.9	2.2	2.9	1.6
Tanning	0.1	1.5	2.7	1.6	-0.9	-0.7	1.1	1.3	-1.4
Hand grip strength (left)	2.4	6.4	12.5	-2.2	3.5	-0.4	3.3	0.2	3.1
Number of treatments/medications taken	0.7	1.3	5.5	-1.0	1.0	0.5	0.3	2.3	0.0
Average weekly spirits intake	2.6	3.2	4.5	2.1	-1.0	-1.8	-1.8	-2.0	-1.8
Sensitivity / hurt feelings	0.7	1.1	3.6	-0.8	0.6	0.7	0.6	1.9	1.2
Frequency of depressed mood in last 2 weeks	1.5	2.0	5.8	0.1	-0.8	2.4	-0.9	2.1	-0.6
Hearing difficulty/problems: Yes	2.9	4.4	11.0	3.3	-1.5	-2.1	-1.4	0.1	-2.6
Relative age of first facial hair	1.1	2.2	3.6	-1.9	-0.0	0.9	1.9	1.5	1.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.5	0.3	0.0	-0.2	0.8	1.9	-0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.8	-0.6	-0.1	-0.0	-0.9	-0.0	0.0
Ever had hysterectomy (womb removed)	0.4	0.4	1.0	1.0	0.8	-0.3	-0.3	-0.3	-0.7
Systolic blood pressure, automated reading	0.3	0.8	1.6	-1.2	1.3	-0.5	-0.7	-0.6	0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.9	0.2	0.1	0.1	0.1	-0.9	0.3
Angina	0.3	0.4	0.6	-0.5	-0.8	-0.0	0.7	0.7	0.7
Medication for hormone replacement therapy	0.4	0.4	1.8	0.6	-0.3	1.3	-0.3	0.1	-0.5
Vitamin and mineral supplements	0.9	1.2	3.6	-0.4	0.9	-0.7	1.9	-0.0	1.5
Supplements: Zinc	1.0	1.1	4.1	1.2	0.9	2.0	-0.3	-0.6	0.2
Medication: Co-codamol	2.1	2.5	8.0	1.5	-0.6	-2.8	-1.1	-1.0	-1.4
Medication: Metformin	1.3	1.9	3.6	1.9	-1.6	-0.2	-0.2	-1.3	-1.9
Diabetes (father)	0.9	1.1	3.0	0.2	-1.3	0.3	-1.7	-1.3	-0.4
Diabetes (mother)	4.2	5.3	15.8	0.8	-2.4	0.2	-4.0	-1.7	-2.7
Severe depression (siblings)	0.7	0.8	2.5	-1.1	-0.3	1.0	-0.1	1.6	0.1
Pack years adult smoking proportion	1.0	1.5	3.2	-0.7	-1.8	-0.1	-0.3	1.4	-1.8
Impedance of leg (right)	1.1	5.3	13.2	0.1	2.3	3.4	0.7	-1.2	3.6
Leg fat-free mass (left)	0.3	1.5	3.5	0.3	-1.1	-1.6	0.9	1.2	-1.9
Trunk fat percentage	1.3	5.4	12.0	2.6	-3.5	-1.5	-1.4	-0.4	-3.0
Hand grip strength (right)	1.7	4.7	11.9	-1.2	3.5	-0.6	2.8	0.2	2.5
Townsend deprivation index at recruitment	0.8	1.2	3.7	-1.9	-0.7	0.7	-0.5	1.4	-0.4
Current tobacco smoking	1.1	1.8	4.8	-2.2	-0.2	1.9	-0.2	1.4	-0.5
Average weekly fortified wine intake	0.4	0.4	1.0	-0.9	0.3	1.0	0.3	-0.8	0.3
Maternal smoking around birth	1.2	1.8	6.4	-0.8	-1.2	-0.3	1.4	2.5	-0.3
Fed-up feelings	0.4	0.8	4.4	0.0	-0.1	0.3	0.6	2.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.8	-0.6	-0.8	0.0	-1.3	0.2	-0.4
Relative age voice broke	1.7	2.6	6.6	-2.6	-0.1	0.8	0.5	2.1	1.9
Taking other prescription medications	0.5	0.8	1.8	-1.1	-0.7	0.5	-0.4	1.4	-1.1
Age when periods started (menarche)	0.9	2.2	5.0	0.1	2.0	1.8	0.3	-1.0	2.2
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.6	0.7	0.5	-0.7	0.3	1.6	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	5.5	0.0	2.0	0.0	0.0	-0.8	2.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.5	0.2	0.2	1.6	-0.8	0.5	0.1
Qualifications: CSEs or equivalent	0.3	0.4	1.1	-0.7	-0.1	-1.1	-0.1	0.7	0.6
Serious illness, injury or assault to yourself	0.7	0.8	2.6	0.1	-0.9	-1.6	-0.8	0.8	0.2
High blood pressure	0.2	0.7	2.7	-0.5	0.6	1.6	0.1	0.7	0.3
Hayfever, allergic rhinitis or eczema	2.4	5.2	9.8	-0.9	3.1	1.4	2.9	2.1	2.4
Multivitamins +/- minerals	0.9	1.1	3.0	0.2	-0.6	0.9	-1.7	-0.5	-1.5
Stomach or abdominal pain in last month	0.4	0.5	1.7	-0.1	-0.5	-1.3	-0.3	-0.7	-0.8
Supplements: Glucosamine	4.6	5.9	9.4	1.8	-2.3	-2.6	-3.1	-2.0	-2.7
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	2.9	1.3	-0.5	0.5	-1.6	-1.4	-1.7
Medication: Atenolol	0.4	0.5	1.5	0.4	-0.5	1.0	-0.5	-1.2	0.1
Medication: Levothyroxine sodium	0.8	1.3	4.3	-0.9	-1.0	0.3	1.2	2.1	0.4
Sitting height	1.1	7.6	18.4	-2.6	1.9	-0.2	4.3	3.1	2.7
Chronic bronchitis/emphysema (father)	0.6	0.7	2.2	-0.3	-1.5	-0.7	-0.4	0.5	-1.0
High blood pressure (mother)	0.3	0.5	1.7	-0.8	-0.2	0.3	-0.5	0.3	1.3
Body mass index (BMI)	1.2	5.0	9.7	1.7	-3.1	-2.5	-1.1	0.7	-3.1
Impedance of leg (left)	0.7	3.6	9.2	-0.5	1.4	3.0	0.2	-1.0	3.0
Leg predicted mass (left)	0.3	1.6	3.9	0.4	-1.1	-1.5	0.8	1.1	-2.0
Trunk fat mass	0.8	3.5	8.2	2.0	-2.9	-1.4	-0.6	0.2	-2.6
Waist circumference	0.7	2.5	6.3	0.5	-2.5	-1.8	-0.1	0.8	-2.1
Number of incorrect matches in round	2.2	3.6	9.7	-1.6	0.6	3.1	-0.0	2.9	-0.7
Past tobacco smoking	0.1	0.2	0.5	-0.7	-0.3	-0.1	-0.3	-0.4	0.3
Alcohol usually taken with meals	0.6	1.0	2.4	0.4	0.7	-1.4	0.3	-1.5	1.0
Nervous feelings	0.8	1.5	6.3	0.1	0.5	2.5	0.0	0.6	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.4	0.3	-0.8	0.1	-1.3	1.8	-0.7
Hearing difficulty/problems with background noise	1.6	2.6	5.6	2.2	-1.2	-1.1	-1.4	0.5	-2.4
Hair/balding pattern: Pattern 2	1.0	1.2	3.3	-0.8	0.5	-1.4	0.7	1.8	0.7
Had menopause	1.5	1.8	5.3	-0.0	0.8	2.0	-2.3	-0.9	-0.3
Had other major operations	0.2	0.2	0.6	0.7	-0.8	-0.3	0.0	-0.3	0.1
Forced vital capacity (FVC)	0.7	2.8	6.5	-2.5	0.3	0.6	2.4	1.2	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.9	-0.8	2.1	0.7	0.6	-0.5	2.4
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	4.7	-0.5	-0.6	1.6	0.7	2.2	-0.9
Qualifications: None of the above	0.3	0.7	2.4	-1.6	0.3	0.0	0.4	-0.3	1.2
Financial difficulties in last 2 years	1.3	1.7	3.6	1.1	-1.9	-0.6	-1.6	0.5	-1.5
Mouth/teeth dental problems	0.5	0.8	2.3	-0.4	1.5	-0.3	0.6	-0.8	1.1
Heart attack	1.4	1.8	5.2	-1.1	1.3	0.5	2.3	1.1	1.0
Allergy	2.9	6.7	10.8	0.9	-2.5	-3.1	-3.1	-3.3	-1.8
Pain all over the body in last month	3.1	3.4	7.3	1.9	-1.5	-1.0	-1.9	-2.7	-1.5
Diabetes (self-reported)	1.6	2.4	4.9	2.1	-2.2	-0.4	-0.1	-1.1	-2.0
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.4	-1.0	0.8	1.1	1.9	1.1	1.0
Medication: Ramipril	0.4	0.5	1.6	-0.2	-0.7	-0.1	-0.3	1.3	-1.0
Medication: Simvastatin	1.2	1.7	5.1	1.2	-2.2	-0.6	0.9	0.9	-1.3
Fluid intelligence score	0.4	0.8	1.7	1.3	0.5	-1.1	0.4	-1.2	0.1
Illnesses of siblings	0.4	0.5	1.3	1.1	0.7	0.5	0.8	-0.4	-0.5
Neuroticism score	0.4	0.9	2.6	1.1	-0.3	1.0	-0.5	1.6	-0.2
Weight	0.4	2.0	3.0	0.6	-1.6	-1.6	0.9	1.5	-1.7
Impedance of arm (right)	0.5	2.5	6.0	1.4	-1.3	2.5	-1.2	-2.0	0.5
Arm fat percentage (right)	1.7	6.6	16.5	2.4	-4.1	-1.9	-1.7	-0.3	-3.3
Trunk fat-free mass	0.6	3.6	8.8	-2.1	1.5	-0.5	3.0	2.3	0.7
Hip circumference	0.3	1.5	2.8	0.7	-1.7	-1.4	0.3	1.1	-1.6
Time employed in main current job	0.1	0.1	0.3	-0.4	-0.5	0.4	0.5	0.0	0.0
Alcohol intake versus 10 years previously	0.3	0.4	1.7	-0.3	-0.6	-0.2	0.2	0.5	-1.3
Father’s age at death	0.8	1.1	3.2	0.5	0.4	-1.5	-0.7	-1.8	-0.1
Worrier / anxious feelings	0.3	0.6	1.1	0.6	-0.6	1.0	-0.8	1.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	2.9	4.8	10.2	1.7	-3.2	-0.6	-1.4	2.5	-2.6
Falls in the last year	0.6	0.9	1.9	0.5	0.4	1.2	-1.4	1.2	-0.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.2	0.5	-1.0	0.2	-0.0	0.4	-1.1
Number of live births	0.6	0.8	3.0	-0.5	0.5	-0.0	1.7	1.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.0	-0.3	-1.0	-1.0	0.8	-0.0	-0.5
Pulse rate	0.3	0.5	1.0	-0.6	-1.0	0.1	0.8	1.0	-0.3
Happiness	0.3	0.4	1.0	-0.5	0.7	1.0	-0.2	0.6	-0.1
Noisy workplace	2.2	2.8	5.0	1.7	-2.2	0.9	-2.0	-0.2	-2.0
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.8	-0.5	0.7	1.3	0.9	0.1	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.8	0.7	-0.4	-0.7	-0.3	0.7	-0.9
Mouth/teeth dental problems: Dentures	1.5	2.6	6.4	1.1	-2.4	-0.8	-1.3	0.3	-2.5
Asthma	2.1	4.1	10.7	-1.5	-0.1	3.3	1.6	3.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.1	0.2	0.8	-0.2	0.6	-0.1
Medication: Cholesterol lowering	1.3	2.1	6.3	2.5	-1.2	-1.3	0.4	-0.2	-1.7
Depression (self-reported)	0.3	0.4	1.3	-0.6	0.0	0.7	-0.2	1.1	-0.1
Medication: Lansoprazole	1.2	1.4	1.8	-1.3	1.1	-0.8	1.3	1.1	1.4
Prospective memory result	1.5	1.9	4.9	-2.2	1.0	1.3	0.6	-0.1	1.8
Lung cancer (father)	2.0	2.3	7.3	-2.7	0.1	-1.2	-1.0	2.0	-0.4
Illnesses of mother	1.2	1.5	3.3	-0.8	1.8	-0.8	1.8	-0.2	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.3	-0.1	0.1	-0.1	1.5	0.9	0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	-0.3	-0.9	0.4	0.1	0.5	0.3
Impedance of arm (left)	0.3	1.4	2.6	1.6	-1.0	1.4	-0.6	-1.6	0.4
Arm fat mass (right)	1.0	4.1	10.2	1.7	-3.2	-1.5	-0.8	0.7	-2.8
Trunk predicted mass	0.7	3.7	9.0	-2.1	1.5	-0.5	3.0	2.4	0.8
Standing height	0.8	7.9	18.7	-2.2	3.0	1.9	4.3	1.8	2.8
Length of working week for main job	2.0	2.3	5.7	1.5	-1.5	-1.4	-1.1	-0.2	-2.4
Exposure to tobacco smoke at home	0.2	0.3	1.2	0.0	0.2	-0.2	-0.5	0.0	1.1
Breastfed as a baby	0.8	1.1	4.2	0.4	-0.7	-1.1	-0.3	-2.0	-0.4
Tense / ‘highly strung’	1.5	2.5	3.7	0.1	1.6	1.9	1.3	1.9	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.8	1.5	-1.2	2.0	-0.9	0.8	-0.7
Hair/balding pattern: Pattern 4	0.7	1.8	3.3	1.6	-0.9	-0.9	-1.4	-1.8	-1.2
Birth weight of first child	0.7	1.2	3.9	1.3	-1.1	2.0	-0.1	0.8	0.2
Peak expiratory flow (PEF)	0.9	2.0	5.4	1.1	-0.6	-2.3	0.5	-2.1	-0.6
Pulse wave reflection index	0.3	0.4	1.1	-0.1	-0.3	-1.1	-0.4	-0.8	-0.2
Ever highly irritable/argumentative for 2 days	1.3	1.6	5.2	0.5	-2.3	1.0	-1.2	0.9	-0.9
Loud music exposure frequency	1.4	1.6	3.1	1.0	-1.3	1.4	-1.2	0.4	-1.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	-1.1	0.2	1.0	-0.1	1.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.2	-1.1	0.7	-0.8	0.3	-0.2
Blood clot in the leg (DVT)	0.7	0.9	2.4	1.6	-0.7	0.5	-0.8	1.0	-0.6
Medication: Paracetamol	0.3	0.5	1.8	-0.5	-0.1	0.9	0.3	1.4	-0.1
Headache pain in last month	3.1	5.4	10.6	3.1	-2.6	-0.8	-2.0	-0.8	-3.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.0	-1.9	1.3	0.0	0.8	0.7	2.0
Glaucoma (self-reported)	0.4	0.5	0.8	-0.9	-0.9	-0.2	0.8	0.7	0.3
Gout (self-reported)	2.7	3.7	11.5	-3.4	1.5	-0.3	1.6	1.5	1.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	-1.2	-1.4	0.1	0.8	1.6	0.1
Medication: Amlodipine	0.1	0.2	0.5	-0.4	0.6	-0.7	0.3	-0.3	-0.3
Medication: Ventolin 100micrograms inhaler	0.8	1.0	4.0	0.3	-0.4	1.3	0.2	0.6	-2.0
Birth weight	0.9	2.0	4.7	-2.2	1.1	1.0	0.8	0.4	2.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.8	-0.7	-1.4	0.5	-0.1	0.4	0.3
High blood pressure (siblings)	0.3	0.4	1.0	-0.3	-0.4	-1.0	-0.3	0.8	0.7
Forced vital capacity (FVC), Best measure	1.4	5.2	9.0	-2.6	1.6	1.4	3.0	2.3	2.3
Body fat percentage	1.5	5.8	13.2	2.6	-3.6	-1.8	-1.5	-0.5	-3.0
Leg fat percentage (right)	0.7	2.7	6.6	2.2	-2.6	-1.4	-0.5	0.1	-1.6
Arm fat-free mass (right)	0.4	2.0	4.5	-1.2	1.0	-1.1	2.0	2.1	-0.1
Exposure to tobacco smoke outside home	0.7	0.9	2.8	-0.3	-0.8	-1.0	0.8	1.7	-0.0
Comparative body size at age 10	0.2	0.6	1.7	-0.6	-0.5	0.7	0.6	0.7	-1.3
Number of full brothers	0.5	0.6	1.9	-0.6	-1.4	0.4	-1.2	0.1	-0.1
Worry too long after embarrassment	0.8	1.3	4.1	1.4	0.0	-0.6	-2.0	-0.9	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.8	3.6	4.8	2.2	-2.1	2.0	-2.0	0.8	-1.9
Wheeze or whistling in the chest in last year	1.4	2.5	7.7	0.3	-1.8	2.8	-0.8	1.4	-1.3
Number of children fathered	1.9	2.1	5.8	1.4	-1.5	-0.1	-0.9	-2.4	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.5	0.1	-0.2	0.1	0.4	-0.4
Age at first live birth	0.9	1.6	3.7	-1.2	1.9	1.6	0.9	0.1	1.0
Pulse wave peak to peak time	0.2	0.2	1.0	0.2	1.0	-0.3	0.1	-0.6	-0.1
Health satisfaction	0.4	0.5	1.4	-0.7	-1.0	-0.1	-0.4	1.2	0.2
Shortness of breath walking on level ground	1.0	1.2	3.8	-1.9	-0.8	0.1	0.7	1.6	0.1
Qualifications: College or University degree	0.8	2.5	4.6	-0.4	2.1	0.7	2.1	1.7	1.5
Eye problems/disorders: None of the above	1.8	2.0	6.0	-0.3	2.4	-0.7	1.4	1.5	1.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.2	-0.4	-0.7	0.4	0.7	-0.6
Emphysema/chronic bronchitis	1.3	1.4	4.1	0.4	-1.4	1.0	-0.4	1.2	-2.0
Medication for pain relief, constipation, heartburn	0.2	0.3	0.4	0.5	-0.5	-0.5	-0.4	-0.6	-0.7
Neck or shoulder pain in last month	0.1	0.2	0.9	0.1	-0.1	0.4	-0.3	1.0	-0.2
Medication: Blood pressure	0.3	0.5	1.6	0.7	-0.6	0.5	-0.2	-0.3	-1.3
Angina (self-reported)	0.2	0.3	0.9	-0.2	-1.0	-0.3	0.6	0.5	0.6
Migraine (self-reported)	2.1	2.7	6.2	1.8	-1.4	-2.0	-0.6	-0.4	-2.5
Medication: Ibuprofen	0.3	0.3	0.8	0.8	-0.0	0.9	-0.4	0.3	-0.3
Medication: Allopurinol	1.9	2.6	4.3	-2.1	1.5	-0.1	2.1	1.6	1.4
Medication: Omeprazole	1.6	1.9	4.7	0.7	-1.6	-2.2	-0.8	-0.6	-1.7
Medication: Seretide 50 evohaler	0.6	0.7	2.5	-0.1	1.6	1.0	0.8	0.3	-0.2
Mean time to correctly identify matches	0.3	0.6	2.1	-0.3	0.4	0.6	-0.7	1.5	-0.4
Heart disease (mother)	0.7	0.8	2.8	-0.5	-0.8	0.7	0.4	1.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.2	0.2	-1.3	-1.5	-0.4	-1.5	-1.2
Whole body fat mass	0.9	3.8	8.9	2.0	-3.0	-1.4	-0.6	0.4	-2.7
Leg fat mass (right)	0.8	3.1	8.1	1.9	-2.8	-1.4	-0.6	0.3	-2.2
Arm predicted mass (right)	0.4	2.1	4.0	-1.5	1.1	-0.9	2.0	2.0	-0.1
Pulse rate, automated reading	0.4	1.4	4.0	-2.0	-0.3	0.4	1.4	1.4	0.6
Alcohol intake frequency.	3.2	7.5	12.8	1.9	-2.9	-3.4	-2.9	-0.8	-3.6
Comparative height size at age 10	0.1	0.5	1.5	-0.6	0.7	1.2	0.3	0.5	-0.1
Number of full sisters	1.5	1.8	4.2	-0.8	-2.1	-0.9	-1.7	0.1	-1.6
Suffer from ‘nerves’	2.3	3.6	10.6	0.3	1.1	2.1	1.8	3.2	1.6
Overall health rating	0.5	1.2	4.3	0.3	-1.1	0.5	-0.7	2.1	-0.8
Chest pain or discomfort	0.0	0.1	0.2	0.1	-0.2	-0.3	0.1	0.5	-0.2
Had major operations	1.0	1.2	4.8	-1.3	0.2	2.2	-0.7	0.2	0.5
Age at last live birth	0.8	1.2	2.6	-0.8	1.6	1.0	1.3	0.5	0.9
Family relationship satisfaction	0.3	0.4	0.9	0.8	0.6	0.8	0.1	0.1	1.0
Leg pain on walking	2.0	2.5	6.5	-2.0	0.7	-0.8	1.5	2.5	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.2	0.9	-0.2	1.8	0.2	0.2	0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	2.2	0.3	-0.0	0.1	0.4	-1.5	0.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.0	-0.5	1.5	0.4	1.7	-0.6	0.6
Medication: Aspirin	0.3	0.4	0.9	-0.2	0.2	1.0	0.9	0.9	0.1
Supplements: Vitamin C	0.5	0.6	2.2	0.4	-0.4	1.5	-0.9	-0.4	0.2
Knee pain experienced in last month	0.8	1.3	4.2	-1.4	-0.3	-0.4	1.1	2.1	-0.0
Hypertension (Self-reported)	0.2	0.7	3.2	-0.2	-0.0	1.8	-0.2	0.8	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.3	-0.1	-0.2	0.0	-1.2	-1.5	0.3
Illnesses of father: Heart disease	1.4	1.9	5.6	-0.3	0.5	-2.4	2.3	0.1	0.7
Illnesses of siblings: Diabetes	2.8	3.4	8.2	1.6	-2.3	0.4	-1.9	-0.4	-2.9
Smoking status: Previous	0.1	0.2	0.9	1.0	0.4	-0.2	0.2	-0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	5.5	-1.6	1.1	0.9	2.3	0.5	1.3
Whole body fat-free mass	0.4	2.0	5.0	-1.3	0.5	-1.0	2.2	2.1	-0.4
Leg fat-free mass (right)	0.3	1.8	4.1	-0.1	-1.3	-1.7	0.7	1.3	-2.0
Arm fat percentage (left)	1.9	7.4	17.3	2.6	-4.2	-2.4	-1.6	-0.2	-3.5
Average weekly red wine intake	1.3	1.9	5.5	-0.9	1.4	0.0	1.8	0.2	2.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.0	-0.5	0.5	-0.1	1.7	-0.3	0.3
Mood swings	0.2	0.3	1.2	0.3	0.1	-0.1	0.5	1.1	-0.3
Loneliness, isolation	1.9	2.6	5.7	0.7	-2.4	1.0	-1.8	1.7	-1.7
Long-standing illness, disability or infirmity	1.0	1.5	4.6	0.3	-1.3	-0.2	-0.2	1.6	-2.1
Ever had bowel cancer screening	0.6	0.7	2.0	-1.1	-1.0	-1.4	0.5	0.2	0.1
Diabetes diagnosed by doctor	1.7	2.7	6.4	1.9	-2.5	-0.7	0.2	-0.8	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	-0.1	-0.9	0.1	-0.1	-0.5	-1.0
Friendships satisfaction	0.7	0.8	1.6	-0.1	1.1	1.2	0.4	-0.8	1.2
Qualifications: nursing, teaching	1.1	1.7	3.7	-0.9	1.2	-1.9	1.3	-0.5	1.6
Commuting to job workplace: Walk	2.7	3.0	9.5	-1.7	0.9	1.2	1.0	3.1	1.4
Eye problems/disorders: Cataract	0.4	0.4	1.1	-0.3	-0.9	0.2	-0.8	-1.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.8	-0.5	0.0	-0.0	0.9	0.4	0.2
Medication for cholesterol	0.6	0.9	3.1	0.8	0.5	-1.0	-0.7	-1.8	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	6.7	0.3	-0.8	0.9	-2.6	-1.4	-1.1
Back pain experienced in last month	0.4	0.6	2.2	0.1	-0.8	1.5	0.7	0.6	0.0
Mineral and other dietary supplements	0.3	0.5	2.1	0.1	-0.5	0.5	1.4	0.1	0.4
Breast cancer (self-reported)	0.1	0.2	0.4	0.5	-0.3	-0.1	-0.3	-0.6	-0.3
Asthma (self-reported)	1.9	3.8	9.8	-1.6	0.0	3.1	1.6	2.8	0.1
Osteoporosis (self-reported)	0.5	0.6	1.6	0.9	0.8	-0.6	0.0	-1.3	0.5
Osteoarthritis (self-reported)	1.4	1.8	5.4	-0.4	-1.8	-2.3	-0.5	1.0	-0.9
Medication: Aspirin	0.5	0.6	1.6	-0.3	0.2	1.1	1.3	0.9	0.3
Medication: Gliclazide	1.1	1.2	3.4	0.2	-1.8	-0.6	-0.5	-0.4	-1.8
Illnesses of father: None of the above (group 1)	0.9	1.1	4.8	-0.2	2.2	1.1	0.0	0.2	0.8
Smoking status: Current	1.1	1.8	4.7	-2.2	-0.2	1.8	-0.0	1.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.4	-0.1	-0.9	-1.2	0.8	0.4	0.0
Whole body water mass	0.3	1.8	4.2	-1.2	0.5	-0.9	2.0	2.0	-0.4
Leg predicted mass (right)	0.3	1.8	4.0	-0.1	-1.2	-1.7	0.8	1.3	-2.0
Arm fat mass (left)	0.9	3.6	8.1	1.7	-2.8	-1.8	-0.6	0.7	-2.6
Number of self-reported non-cancer illnesses	1.6	2.7	5.0	0.8	-2.1	1.2	-0.2	2.2	-2.2
Average weekly champagne plus white wine intake	0.7	1.0	2.2	-0.4	0.2	-1.2	1.0	-1.0	1.5
Miserableness	1.7	2.9	15.0	-0.0	-0.5	0.9	0.7	3.9	-1.0
Guilty feelings	1.1	1.7	5.6	1.1	-0.4	-0.4	-2.4	-1.5	-0.8
Wears glasses or contact lenses	0.9	1.0	3.3	0.9	-0.3	-1.2	-0.3	-0.6	-1.8
Ever taken oral contraceptive pill	1.3	1.5	3.7	-1.9	1.3	0.7	0.7	0.8	1.3
Hearing aid user	0.5	0.5	2.3	0.2	1.5	-0.7	-0.4	-0.5	0.1
Mother’s age at death	0.4	0.5	1.1	-0.8	0.8	-0.3	-0.2	-1.1	0.6
Financial situation satisfaction	2.5	3.1	9.9	1.0	-3.1	-1.1	-0.8	0.3	-2.4
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.6	0.5	-2.4	1.9	-1.3	-0.8	-0.7
Commuting to job workplace: Public transport	0.4	0.5	1.6	0.3	-0.1	0.7	-1.3	0.1	-0.8
Eye problems/disorders: Glaucoma	0.9	1.0	2.4	-1.5	-0.1	-1.0	1.2	0.5	1.1
Medication: Blood pressure	0.6	1.2	2.3	-1.5	0.7	0.8	0.8	1.2	1.4
Pain type(s) experienced in last month: Hip pain	0.8	1.1	5.1	-0.6	0.4	0.2	0.8	2.3	0.2
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.6	-1.6	2.1	0.3	0.2	0.5	1.6
High cholesterol (Self-reported)	1.7	3.0	6.7	2.6	-2.3	-1.6	-0.2	-0.2	-1.8
Medication: Bendroflumethiazide	0.9	1.4	2.5	0.5	1.1	0.7	1.6	1.2	1.5
Medication: Paracetamol	0.8	1.2	2.8	0.1	-1.0	1.4	-0.5	1.7	-1.1
Medication: Lisinopril	0.4	0.6	1.2	-1.0	0.8	0.1	0.2	0.6	1.1
Medication: Atorvastatin	0.8	1.0	3.1	1.8	-1.1	-0.1	0.1	0.3	-1.4
Illnesses of father: High blood pressure	0.4	0.4	1.7	0.1	-1.3	0.2	-0.6	-0.5	-0.5
Alcohol drinker status: Never	0.6	0.7	2.3	-0.5	0.7	-0.9	1.5	0.7	0.1
Ever smoked	0.1	0.2	0.6	0.7	0.3	0.0	-0.3	-0.2	-0.8
Basal metabolic rate	0.3	1.6	4.0	-0.8	-0.1	-1.1	1.8	2.0	-0.7
Leg fat percentage (left)	0.9	3.2	9.1	1.6	-3.0	-1.6	-0.9	0.2	-2.0
Arm fat-free mass (left)	0.4	1.9	4.3	-1.5	1.1	-0.4	1.9	2.1	0.2
Number of operations (self-reported)	0.3	0.4	1.4	-0.2	-0.6	-1.2	-0.1	-0.0	-0.9
Average weekly beer plus cider intake	2.0	3.0	5.9	-2.1	0.6	2.4	0.9	2.0	1.4
Irritability	0.5	0.9	3.9	0.6	-0.1	1.0	0.2	2.0	-0.1
Risk taking	0.4	0.6	1.8	1.3	-0.4	0.4	0.4	-0.9	-0.6
Ever had prostate specific antigen (PSA) test	1.5	1.8	4.2	-1.9	1.2	0.3	2.0	0.2	1.1
Fractured/broken bones in last 5 years	0.5	0.6	1.2	-1.1	0.6	0.0	0.8	0.9	0.8
Age started oral contraceptive pill	1.1	1.4	4.7	-1.1	2.2	-0.3	0.4	-0.1	1.4
Diastolic blood pressure, automated reading	0.2	0.7	2.3	0.1	1.5	-0.1	0.7	-1.1	0.7
Ever depressed for a whole week	1.0	1.2	2.3	1.0	-1.5	1.3	-0.6	0.9	-1.2
Unable to work because of sickness or disability	0.3	0.4	1.4	0.4	-0.6	0.1	-0.6	1.2	-0.2
Commuting to job workplace: Cycle	0.3	0.3	1.1	0.5	1.1	-0.0	-0.1	0.6	-0.6
Myopia	0.6	0.8	3.5	-0.1	1.9	-0.5	-0.1	-0.6	1.0
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.9	0.2	0.0	-2.0	-0.3	-1.3	-0.4
Cholesterol lowering medication	1.3	1.9	6.3	-0.3	-2.5	0.6	0.3	1.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	5.3	1.4	-1.7	-2.3	-0.7	-0.2	-1.9
Pain experienced in last month	0.5	0.8	2.2	-0.6	1.5	-0.1	0.8	-0.0	1.3
Supplements: Calcium	0.5	0.5	2.1	-0.1	0.8	1.5	0.0	0.5	-0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	0.7	0.2	1.0	0.4	1.0	-1.0
Heart attack/myocardial infarction (self-reported)	1.1	1.5	4.7	-1.0	1.0	0.4	2.2	1.2	0.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.2	1.5	-1.0	0.3	-0.8	1.2	-0.9
Heart disease (siblings)	0.3	0.3	0.7	-0.6	-0.8	-0.1	-0.8	-0.4	0.1
Alcohol drinker status: Previous	0.4	0.5	1.7	0.6	-0.0	0.2	-1.3	-0.8	-0.1
Pack years of smoking	0.8	1.2	2.2	-1.0	-1.4	-0.6	-0.1	1.2	-1.5
Impedance of whole body	0.4	2.3	7.1	0.9	0.2	2.7	-0.3	-1.4	1.9
Leg fat mass (left)	1.0	3.9	10.3	1.7	-3.2	-1.5	-0.9	0.3	-2.6
Arm predicted mass (left)	0.4	2.1	4.2	-1.6	1.3	-0.6	2.0	2.1	0.3