Hub : Genes

B4GALT5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0550 0.0240 4.4e-03 0.033 0.022 0.055 0.032 0.052 6.4e-05 9.9e-04 3.0e-07 7.0e-05 5.2e-07
2 GTEx Cells Transformed fibroblasts 0.1080 0.0410 2.3e-03 0.023 NA 0.023 NA 0.025 7.1e-03 NA 7.1e-03 NA 4.9e-03
3 GTEx Muscle Skeletal 0.0767 0.0312 4.7e-03 -0.002 NA 0.004 NA 0.001 6.6e-01 NA 1.2e-01 NA 2.4e-01
4 ROSMAP Brain Pre-frontal Cortex 0.1994 0.0357 6.7e-16 0.109 0.141 0.146 0.156 0.154 8.3e-14 9.9e-18 2.4e-18 1.6e-19 3.0e-19
5 YFS Blood 0.0343 0.0135 1.8e-03 0.007 0.012 0.007 0.012 0.010 1.6e-03 6.9e-05 1.5e-03 4.1e-05 2.2e-04
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0233 0.0143 6.9e-03 0.006 0.000 -0.001 NA 0.000 7.0e-02 3.2e-01 5.1e-01 NA 3.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.9 1.4 5.7 0.1 -0.4 0.8 0.9 2.4 -1.1
Bipolar Disorder or Schizophrenia 1.5 3.7 15.5 -1.0 0.3 2.2 0.6 3.9 -0.6
Depressed Affect (Nagel 2018) 0.6 1.2 3.7 0.8 -0.7 1.1 -0.0 1.9 -1.2
Depression (Nagel 2018) 0.9 1.4 3.1 0.1 -1.1 1.8 -1.2 0.9 -1.4
Intelligence (Savage-Jansen 2018) 0.6 1.9 5.3 2.0 -0.1 -2.3 -0.4 -1.0 -0.9
Neuroticism (Nagel 2018) 0.5 1.1 3.1 0.7 0.3 1.7 -0.4 1.8 -0.2
Schizophrenia (2018) 1.4 2.9 9.8 -1.5 0.6 2.2 0.0 3.1 0.1
Schizophrenia vs Biploar Disorder 0.9 1.2 4.2 -2.0 0.4 -0.9 0.4 1.2 0.6
Worry (Nagel 2018) 1.0 2.1 7.1 1.3 1.0 2.7 0.3 1.5 0.6
Alzheimer’s Disease (in mother) 0.2 0.2 0.7 -0.2 0.4 0.8 0.1 0.0 0.5
Alzheimer’s Disease (in father) 0.8 0.9 2.8 -0.9 0.2 1.0 0.7 1.7 0.5
Alzheimer’s Disease (including proxy) 0.6 0.9 5.1 -0.2 -0.2 2.3 -0.1 0.6 -0.2
Crohns Disease (2017) 0.4 0.9 2.2 -1.2 0.7 1.5 -0.4 0.9 -0.0
Irritable Bowel Disease (IBD) 0.5 1.1 2.3 -0.7 1.4 0.5 1.4 1.5 0.3
Ulcerative Colitis (UC) 1.2 2.3 7.0 -0.6 1.6 -0.4 2.6 1.8 0.7
Major Depression (MDD) 1.3 1.6 3.3 1.6 -1.4 1.8 -0.6 1.2 -0.4
Reaction Time 0.3 0.6 1.4 0.6 0.0 1.0 -0.8 1.2 -0.6
Verbal and Numeric Reasoning (VNR) 0.8 1.9 6.3 2.5 0.4 -1.9 -0.0 -0.4 -1.1
Breast Cancer 0.8 2.0 6.7 -1.0 2.6 0.5 0.4 -0.8 1.9
Ovarian Cancer 0.5 0.7 4.1 0.2 0.1 2.0 0.1 -0.2 0.4
Prostate Cancer 0.5 0.7 2.4 0.3 -1.5 -0.5 0.4 0.3 -1.2
Age at First Birth 0.1 0.2 0.4 0.6 -0.3 0.5 -0.4 -0.3 0.0
Bipolar Disorder (2011) 1.5 1.5 4.6 -0.9 1.1 2.1 0.6 1.3 0.3
Body Mass Index (BMI) (2010) 0.6 0.8 1.6 0.5 -0.6 -1.1 -0.0 -1.3 -1.2
Coronary Artery Disease (CAD) 0.5 0.6 1.7 1.3 0.5 -0.3 -0.4 -0.7 -1.1
Crohns Disease (2012) 0.5 0.8 3.8 0.4 0.4 2.0 -0.6 -0.0 -0.6
Mean Putamen Volume 6.6 7.5 12.2 3.5 -3.2 -1.2 -2.5 -2.2 -3.2
Fasting Glucose 1.0 1.2 4.0 1.4 0.1 -0.7 -0.4 -0.5 -2.0
HbA1C 0.5 0.6 2.0 -0.6 0.3 0.1 1.4 1.0 0.4
HDL Cholesterol 0.1 0.2 0.5 0.3 0.5 0.1 0.7 0.0 0.6
LDL Cholesterol 0.6 1.0 3.0 1.7 -1.1 -1.0 -0.5 -0.1 -0.6
Lupus 0.2 0.3 0.8 -0.1 0.1 -0.5 0.9 -0.9 0.5
Neuroticism (2016) 0.9 1.3 3.5 -1.9 -0.0 -0.6 0.6 1.8 -0.1
Primary Biliary Cirrhosis 2.0 2.9 8.9 -1.7 3.0 0.6 0.7 -0.7 2.0
Rheumatoid Arthritis 1.4 1.9 6.6 2.6 -1.6 0.4 -0.6 -0.1 -1.3
Schizophrenia (2014) 1.9 4.1 13.4 -1.8 1.2 2.4 0.2 3.7 0.7
Triglycerides 0.9 1.5 2.9 -1.1 -1.4 0.7 -1.7 1.2 -1.1
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.9 1.4 -1.3 0.1 -0.6 -0.2 -2.0
Ulcerative Colitis 1.9 2.8 6.6 -0.4 1.6 1.2 2.6 2.2 1.1
Blood Eosinophil Count 0.2 1.3 4.1 -0.1 1.8 2.0 0.4 -0.2 0.8
Blood Platelet Count 0.2 2.0 6.5 1.0 -1.2 2.5 0.2 1.8 0.4
Blood Red Count 0.7 6.5 11.6 2.8 -1.4 -3.3 -1.9 -1.8 -3.4
Blood White Count 0.1 0.5 1.2 -0.0 -0.8 0.6 1.1 0.0 -0.7
Heel T-Score 0.4 2.9 6.9 0.8 1.9 -2.2 -0.2 -2.6 1.4
BMI 1.2 6.7 16.1 1.8 -3.3 -2.4 -2.0 -0.9 -4.0
Height 0.3 5.2 15.2 -2.0 1.7 1.0 3.9 1.8 2.1
Waist Hip Ratio (WHR) 0.2 0.8 1.8 -0.2 -1.3 0.9 -0.1 0.7 -1.3
Systolic Blood Pressure 1.6 7.9 17.3 -2.9 4.2 -0.2 1.8 -1.1 4.1
Smoking Status 0.7 1.8 5.7 -1.3 0.2 2.4 -0.2 1.7 -0.4
Allergy or Eczema 3.1 8.2 13.0 -1.7 3.2 1.7 3.6 3.6 2.7
Cardiovascular Disease 0.3 1.1 2.9 0.1 -1.3 1.3 0.3 1.7 -0.5
Hypothyroidism (self reported) 0.4 0.9 2.5 -0.7 -1.6 -1.1 0.1 1.2 -0.2
Respiratory disease 1.0 2.3 7.7 -0.4 -0.9 2.8 1.0 2.0 -0.5
Type 2 Diabetes (T2D) (2018) 2.7 5.0 13.1 2.5 -3.6 -0.3 -0.9 -0.8 -3.0
Lung FEV1/FVC ratio 3.9 19.6 40.5 6.4 -3.6 -3.0 -3.7 -3.3 -5.5
Lung FVC 0.7 3.6 8.7 -2.9 0.2 -0.5 1.5 3.0 1.4
Neuroticism 0.7 1.6 5.7 0.7 0.3 1.8 0.1 2.4 0.1
Chronotype (morning person) 0.2 0.5 1.0 -0.8 -0.3 -0.9 1.0 0.6 0.3
Hair Pigment 0.1 3.2 8.6 -1.1 1.2 -0.9 2.2 2.9 1.6
Tanning 0.1 1.5 2.7 1.6 -0.9 -0.7 1.1 1.3 -1.4
Hand grip strength (left) 2.4 6.4 12.5 -2.2 3.5 -0.4 3.3 0.2 3.1
Number of treatments/medications taken 0.7 1.3 5.5 -1.0 1.0 0.5 0.3 2.3 0.0
Average weekly spirits intake 2.6 3.2 4.5 2.1 -1.0 -1.8 -1.8 -2.0 -1.8
Sensitivity / hurt feelings 0.7 1.1 3.6 -0.8 0.6 0.7 0.6 1.9 1.2
Frequency of depressed mood in last 2 weeks 1.5 2.0 5.8 0.1 -0.8 2.4 -0.9 2.1 -0.6
Hearing difficulty/problems: Yes 2.9 4.4 11.0 3.3 -1.5 -2.1 -1.4 0.1 -2.6
Relative age of first facial hair 1.1 2.2 3.6 -1.9 -0.0 0.9 1.9 1.5 1.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 3.5 0.3 0.0 -0.2 0.8 1.9 -0.8
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.8 -0.6 -0.1 -0.0 -0.9 -0.0 0.0
Ever had hysterectomy (womb removed) 0.4 0.4 1.0 1.0 0.8 -0.3 -0.3 -0.3 -0.7
Systolic blood pressure, automated reading 0.3 0.8 1.6 -1.2 1.3 -0.5 -0.7 -0.6 0.6
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.9 0.2 0.1 0.1 0.1 -0.9 0.3
Angina 0.3 0.4 0.6 -0.5 -0.8 -0.0 0.7 0.7 0.7
Medication for hormone replacement therapy 0.4 0.4 1.8 0.6 -0.3 1.3 -0.3 0.1 -0.5
Vitamin and mineral supplements 0.9 1.2 3.6 -0.4 0.9 -0.7 1.9 -0.0 1.5
Supplements: Zinc 1.0 1.1 4.1 1.2 0.9 2.0 -0.3 -0.6 0.2
Medication: Co-codamol 2.1 2.5 8.0 1.5 -0.6 -2.8 -1.1 -1.0 -1.4
Medication: Metformin 1.3 1.9 3.6 1.9 -1.6 -0.2 -0.2 -1.3 -1.9
Diabetes (father) 0.9 1.1 3.0 0.2 -1.3 0.3 -1.7 -1.3 -0.4
Diabetes (mother) 4.2 5.3 15.8 0.8 -2.4 0.2 -4.0 -1.7 -2.7
Severe depression (siblings) 0.7 0.8 2.5 -1.1 -0.3 1.0 -0.1 1.6 0.1
Pack years adult smoking proportion 1.0 1.5 3.2 -0.7 -1.8 -0.1 -0.3 1.4 -1.8
Impedance of leg (right) 1.1 5.3 13.2 0.1 2.3 3.4 0.7 -1.2 3.6
Leg fat-free mass (left) 0.3 1.5 3.5 0.3 -1.1 -1.6 0.9 1.2 -1.9
Trunk fat percentage 1.3 5.4 12.0 2.6 -3.5 -1.5 -1.4 -0.4 -3.0
Hand grip strength (right) 1.7 4.7 11.9 -1.2 3.5 -0.6 2.8 0.2 2.5
Townsend deprivation index at recruitment 0.8 1.2 3.7 -1.9 -0.7 0.7 -0.5 1.4 -0.4
Current tobacco smoking 1.1 1.8 4.8 -2.2 -0.2 1.9 -0.2 1.4 -0.5
Average weekly fortified wine intake 0.4 0.4 1.0 -0.9 0.3 1.0 0.3 -0.8 0.3
Maternal smoking around birth 1.2 1.8 6.4 -0.8 -1.2 -0.3 1.4 2.5 -0.3
Fed-up feelings 0.4 0.8 4.4 0.0 -0.1 0.3 0.6 2.1 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.8 -0.6 -0.8 0.0 -1.3 0.2 -0.4
Relative age voice broke 1.7 2.6 6.6 -2.6 -0.1 0.8 0.5 2.1 1.9
Taking other prescription medications 0.5 0.8 1.8 -1.1 -0.7 0.5 -0.4 1.4 -1.1
Age when periods started (menarche) 0.9 2.2 5.0 0.1 2.0 1.8 0.3 -1.0 2.2
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 2.6 0.7 0.5 -0.7 0.3 1.6 -1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.7 5.5 0.0 2.0 0.0 0.0 -0.8 2.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.5 0.2 0.2 1.6 -0.8 0.5 0.1
Qualifications: CSEs or equivalent 0.3 0.4 1.1 -0.7 -0.1 -1.1 -0.1 0.7 0.6
Serious illness, injury or assault to yourself 0.7 0.8 2.6 0.1 -0.9 -1.6 -0.8 0.8 0.2
High blood pressure 0.2 0.7 2.7 -0.5 0.6 1.6 0.1 0.7 0.3
Hayfever, allergic rhinitis or eczema 2.4 5.2 9.8 -0.9 3.1 1.4 2.9 2.1 2.4
Multivitamins +/- minerals 0.9 1.1 3.0 0.2 -0.6 0.9 -1.7 -0.5 -1.5
Stomach or abdominal pain in last month 0.4 0.5 1.7 -0.1 -0.5 -1.3 -0.3 -0.7 -0.8
Supplements: Glucosamine 4.6 5.9 9.4 1.8 -2.3 -2.6 -3.1 -2.0 -2.7
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 2.9 1.3 -0.5 0.5 -1.6 -1.4 -1.7
Medication: Atenolol 0.4 0.5 1.5 0.4 -0.5 1.0 -0.5 -1.2 0.1
Medication: Levothyroxine sodium 0.8 1.3 4.3 -0.9 -1.0 0.3 1.2 2.1 0.4
Sitting height 1.1 7.6 18.4 -2.6 1.9 -0.2 4.3 3.1 2.7
Chronic bronchitis/emphysema (father) 0.6 0.7 2.2 -0.3 -1.5 -0.7 -0.4 0.5 -1.0
High blood pressure (mother) 0.3 0.5 1.7 -0.8 -0.2 0.3 -0.5 0.3 1.3
Body mass index (BMI) 1.2 5.0 9.7 1.7 -3.1 -2.5 -1.1 0.7 -3.1
Impedance of leg (left) 0.7 3.6 9.2 -0.5 1.4 3.0 0.2 -1.0 3.0
Leg predicted mass (left) 0.3 1.6 3.9 0.4 -1.1 -1.5 0.8 1.1 -2.0
Trunk fat mass 0.8 3.5 8.2 2.0 -2.9 -1.4 -0.6 0.2 -2.6
Waist circumference 0.7 2.5 6.3 0.5 -2.5 -1.8 -0.1 0.8 -2.1
Number of incorrect matches in round 2.2 3.6 9.7 -1.6 0.6 3.1 -0.0 2.9 -0.7
Past tobacco smoking 0.1 0.2 0.5 -0.7 -0.3 -0.1 -0.3 -0.4 0.3
Alcohol usually taken with meals 0.6 1.0 2.4 0.4 0.7 -1.4 0.3 -1.5 1.0
Nervous feelings 0.8 1.5 6.3 0.1 0.5 2.5 0.0 0.6 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 3.4 0.3 -0.8 0.1 -1.3 1.8 -0.7
Hearing difficulty/problems with background noise 1.6 2.6 5.6 2.2 -1.2 -1.1 -1.4 0.5 -2.4
Hair/balding pattern: Pattern 2 1.0 1.2 3.3 -0.8 0.5 -1.4 0.7 1.8 0.7
Had menopause 1.5 1.8 5.3 -0.0 0.8 2.0 -2.3 -0.9 -0.3
Had other major operations 0.2 0.2 0.6 0.7 -0.8 -0.3 0.0 -0.3 0.1
Forced vital capacity (FVC) 0.7 2.8 6.5 -2.5 0.3 0.6 2.4 1.2 1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 5.9 -0.8 2.1 0.7 0.6 -0.5 2.4
Ever unenthusiastic/disinterested for a whole week 1.3 1.5 4.7 -0.5 -0.6 1.6 0.7 2.2 -0.9
Qualifications: None of the above 0.3 0.7 2.4 -1.6 0.3 0.0 0.4 -0.3 1.2
Financial difficulties in last 2 years 1.3 1.7 3.6 1.1 -1.9 -0.6 -1.6 0.5 -1.5
Mouth/teeth dental problems 0.5 0.8 2.3 -0.4 1.5 -0.3 0.6 -0.8 1.1
Heart attack 1.4 1.8 5.2 -1.1 1.3 0.5 2.3 1.1 1.0
Allergy 2.9 6.7 10.8 0.9 -2.5 -3.1 -3.1 -3.3 -1.8
Pain all over the body in last month 3.1 3.4 7.3 1.9 -1.5 -1.0 -1.9 -2.7 -1.5
Diabetes (self-reported) 1.6 2.4 4.9 2.1 -2.2 -0.4 -0.1 -1.1 -2.0
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 3.4 -1.0 0.8 1.1 1.9 1.1 1.0
Medication: Ramipril 0.4 0.5 1.6 -0.2 -0.7 -0.1 -0.3 1.3 -1.0
Medication: Simvastatin 1.2 1.7 5.1 1.2 -2.2 -0.6 0.9 0.9 -1.3
Fluid intelligence score 0.4 0.8 1.7 1.3 0.5 -1.1 0.4 -1.2 0.1
Illnesses of siblings 0.4 0.5 1.3 1.1 0.7 0.5 0.8 -0.4 -0.5
Neuroticism score 0.4 0.9 2.6 1.1 -0.3 1.0 -0.5 1.6 -0.2
Weight 0.4 2.0 3.0 0.6 -1.6 -1.6 0.9 1.5 -1.7
Impedance of arm (right) 0.5 2.5 6.0 1.4 -1.3 2.5 -1.2 -2.0 0.5
Arm fat percentage (right) 1.7 6.6 16.5 2.4 -4.1 -1.9 -1.7 -0.3 -3.3
Trunk fat-free mass 0.6 3.6 8.8 -2.1 1.5 -0.5 3.0 2.3 0.7
Hip circumference 0.3 1.5 2.8 0.7 -1.7 -1.4 0.3 1.1 -1.6
Time employed in main current job 0.1 0.1 0.3 -0.4 -0.5 0.4 0.5 0.0 0.0
Alcohol intake versus 10 years previously 0.3 0.4 1.7 -0.3 -0.6 -0.2 0.2 0.5 -1.3
Father’s age at death 0.8 1.1 3.2 0.5 0.4 -1.5 -0.7 -1.8 -0.1
Worrier / anxious feelings 0.3 0.6 1.1 0.6 -0.6 1.0 -0.8 1.0 -0.3
Frequency of tiredness / lethargy in last 2 weeks 2.9 4.8 10.2 1.7 -3.2 -0.6 -1.4 2.5 -2.6
Falls in the last year 0.6 0.9 1.9 0.5 0.4 1.2 -1.4 1.2 -0.1
Hair/balding pattern: Pattern 3 0.3 0.4 1.2 0.5 -1.0 0.2 -0.0 0.4 -1.1
Number of live births 0.6 0.8 3.0 -0.5 0.5 -0.0 1.7 1.1 0.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 1.0 -0.3 -1.0 -1.0 0.8 -0.0 -0.5
Pulse rate 0.3 0.5 1.0 -0.6 -1.0 0.1 0.8 1.0 -0.3
Happiness 0.3 0.4 1.0 -0.5 0.7 1.0 -0.2 0.6 -0.1
Noisy workplace 2.2 2.8 5.0 1.7 -2.2 0.9 -2.0 -0.2 -2.0
Qualifications: A levels/AS levels or equivalent 0.3 0.8 1.8 -0.5 0.7 1.3 0.9 0.1 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.8 0.7 -0.4 -0.7 -0.3 0.7 -0.9
Mouth/teeth dental problems: Dentures 1.5 2.6 6.4 1.1 -2.4 -0.8 -1.3 0.3 -2.5
Asthma 2.1 4.1 10.7 -1.5 -0.1 3.3 1.6 3.1 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.7 -0.1 0.2 0.8 -0.2 0.6 -0.1
Medication: Cholesterol lowering 1.3 2.1 6.3 2.5 -1.2 -1.3 0.4 -0.2 -1.7
Depression (self-reported) 0.3 0.4 1.3 -0.6 0.0 0.7 -0.2 1.1 -0.1
Medication: Lansoprazole 1.2 1.4 1.8 -1.3 1.1 -0.8 1.3 1.1 1.4
Prospective memory result 1.5 1.9 4.9 -2.2 1.0 1.3 0.6 -0.1 1.8
Lung cancer (father) 2.0 2.3 7.3 -2.7 0.1 -1.2 -1.0 2.0 -0.4
Illnesses of mother 1.2 1.5 3.3 -0.8 1.8 -0.8 1.8 -0.2 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 2.3 -0.1 0.1 -0.1 1.5 0.9 0.4
Pulse wave Arterial Stiffness index 0.2 0.2 0.7 -0.3 -0.9 0.4 0.1 0.5 0.3
Impedance of arm (left) 0.3 1.4 2.6 1.6 -1.0 1.4 -0.6 -1.6 0.4
Arm fat mass (right) 1.0 4.1 10.2 1.7 -3.2 -1.5 -0.8 0.7 -2.8
Trunk predicted mass 0.7 3.7 9.0 -2.1 1.5 -0.5 3.0 2.4 0.8
Standing height 0.8 7.9 18.7 -2.2 3.0 1.9 4.3 1.8 2.8
Length of working week for main job 2.0 2.3 5.7 1.5 -1.5 -1.4 -1.1 -0.2 -2.4
Exposure to tobacco smoke at home 0.2 0.3 1.2 0.0 0.2 -0.2 -0.5 0.0 1.1
Breastfed as a baby 0.8 1.1 4.2 0.4 -0.7 -1.1 -0.3 -2.0 -0.4
Tense / ‘highly strung’ 1.5 2.5 3.7 0.1 1.6 1.9 1.3 1.9 1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.8 1.5 -1.2 2.0 -0.9 0.8 -0.7
Hair/balding pattern: Pattern 4 0.7 1.8 3.3 1.6 -0.9 -0.9 -1.4 -1.8 -1.2
Birth weight of first child 0.7 1.2 3.9 1.3 -1.1 2.0 -0.1 0.8 0.2
Peak expiratory flow (PEF) 0.9 2.0 5.4 1.1 -0.6 -2.3 0.5 -2.1 -0.6
Pulse wave reflection index 0.3 0.4 1.1 -0.1 -0.3 -1.1 -0.4 -0.8 -0.2
Ever highly irritable/argumentative for 2 days 1.3 1.6 5.2 0.5 -2.3 1.0 -1.2 0.9 -0.9
Loud music exposure frequency 1.4 1.6 3.1 1.0 -1.3 1.4 -1.2 0.4 -1.8
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.3 -1.1 0.2 1.0 -0.1 1.1 0.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.1 0.2 -1.1 0.7 -0.8 0.3 -0.2
Blood clot in the leg (DVT) 0.7 0.9 2.4 1.6 -0.7 0.5 -0.8 1.0 -0.6
Medication: Paracetamol 0.3 0.5 1.8 -0.5 -0.1 0.9 0.3 1.4 -0.1
Headache pain in last month 3.1 5.4 10.6 3.1 -2.6 -0.8 -2.0 -0.8 -3.3
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 4.0 -1.9 1.3 0.0 0.8 0.7 2.0
Glaucoma (self-reported) 0.4 0.5 0.8 -0.9 -0.9 -0.2 0.8 0.7 0.3
Gout (self-reported) 2.7 3.7 11.5 -3.4 1.5 -0.3 1.6 1.5 1.9
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 2.7 -1.2 -1.4 0.1 0.8 1.6 0.1
Medication: Amlodipine 0.1 0.2 0.5 -0.4 0.6 -0.7 0.3 -0.3 -0.3
Medication: Ventolin 100micrograms inhaler 0.8 1.0 4.0 0.3 -0.4 1.3 0.2 0.6 -2.0
Birth weight 0.9 2.0 4.7 -2.2 1.1 1.0 0.8 0.4 2.0
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.8 -0.7 -1.4 0.5 -0.1 0.4 0.3
High blood pressure (siblings) 0.3 0.4 1.0 -0.3 -0.4 -1.0 -0.3 0.8 0.7
Forced vital capacity (FVC), Best measure 1.4 5.2 9.0 -2.6 1.6 1.4 3.0 2.3 2.3
Body fat percentage 1.5 5.8 13.2 2.6 -3.6 -1.8 -1.5 -0.5 -3.0
Leg fat percentage (right) 0.7 2.7 6.6 2.2 -2.6 -1.4 -0.5 0.1 -1.6
Arm fat-free mass (right) 0.4 2.0 4.5 -1.2 1.0 -1.1 2.0 2.1 -0.1
Exposure to tobacco smoke outside home 0.7 0.9 2.8 -0.3 -0.8 -1.0 0.8 1.7 -0.0
Comparative body size at age 10 0.2 0.6 1.7 -0.6 -0.5 0.7 0.6 0.7 -1.3
Number of full brothers 0.5 0.6 1.9 -0.6 -1.4 0.4 -1.2 0.1 -0.1
Worry too long after embarrassment 0.8 1.3 4.1 1.4 0.0 -0.6 -2.0 -0.9 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 2.8 3.6 4.8 2.2 -2.1 2.0 -2.0 0.8 -1.9
Wheeze or whistling in the chest in last year 1.4 2.5 7.7 0.3 -1.8 2.8 -0.8 1.4 -1.3
Number of children fathered 1.9 2.1 5.8 1.4 -1.5 -0.1 -0.9 -2.4 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 -0.5 0.1 -0.2 0.1 0.4 -0.4
Age at first live birth 0.9 1.6 3.7 -1.2 1.9 1.6 0.9 0.1 1.0
Pulse wave peak to peak time 0.2 0.2 1.0 0.2 1.0 -0.3 0.1 -0.6 -0.1
Health satisfaction 0.4 0.5 1.4 -0.7 -1.0 -0.1 -0.4 1.2 0.2
Shortness of breath walking on level ground 1.0 1.2 3.8 -1.9 -0.8 0.1 0.7 1.6 0.1
Qualifications: College or University degree 0.8 2.5 4.6 -0.4 2.1 0.7 2.1 1.7 1.5
Eye problems/disorders: None of the above 1.8 2.0 6.0 -0.3 2.4 -0.7 1.4 1.5 1.2
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.5 0.2 -0.4 -0.7 0.4 0.7 -0.6
Emphysema/chronic bronchitis 1.3 1.4 4.1 0.4 -1.4 1.0 -0.4 1.2 -2.0
Medication for pain relief, constipation, heartburn 0.2 0.3 0.4 0.5 -0.5 -0.5 -0.4 -0.6 -0.7
Neck or shoulder pain in last month 0.1 0.2 0.9 0.1 -0.1 0.4 -0.3 1.0 -0.2
Medication: Blood pressure 0.3 0.5 1.6 0.7 -0.6 0.5 -0.2 -0.3 -1.3
Angina (self-reported) 0.2 0.3 0.9 -0.2 -1.0 -0.3 0.6 0.5 0.6
Migraine (self-reported) 2.1 2.7 6.2 1.8 -1.4 -2.0 -0.6 -0.4 -2.5
Medication: Ibuprofen 0.3 0.3 0.8 0.8 -0.0 0.9 -0.4 0.3 -0.3
Medication: Allopurinol 1.9 2.6 4.3 -2.1 1.5 -0.1 2.1 1.6 1.4
Medication: Omeprazole 1.6 1.9 4.7 0.7 -1.6 -2.2 -0.8 -0.6 -1.7
Medication: Seretide 50 evohaler 0.6 0.7 2.5 -0.1 1.6 1.0 0.8 0.3 -0.2
Mean time to correctly identify matches 0.3 0.6 2.1 -0.3 0.4 0.6 -0.7 1.5 -0.4
Heart disease (mother) 0.7 0.8 2.8 -0.5 -0.8 0.7 0.4 1.7 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.2 0.2 -1.3 -1.5 -0.4 -1.5 -1.2
Whole body fat mass 0.9 3.8 8.9 2.0 -3.0 -1.4 -0.6 0.4 -2.7
Leg fat mass (right) 0.8 3.1 8.1 1.9 -2.8 -1.4 -0.6 0.3 -2.2
Arm predicted mass (right) 0.4 2.1 4.0 -1.5 1.1 -0.9 2.0 2.0 -0.1
Pulse rate, automated reading 0.4 1.4 4.0 -2.0 -0.3 0.4 1.4 1.4 0.6
Alcohol intake frequency. 3.2 7.5 12.8 1.9 -2.9 -3.4 -2.9 -0.8 -3.6
Comparative height size at age 10 0.1 0.5 1.5 -0.6 0.7 1.2 0.3 0.5 -0.1
Number of full sisters 1.5 1.8 4.2 -0.8 -2.1 -0.9 -1.7 0.1 -1.6
Suffer from ‘nerves’ 2.3 3.6 10.6 0.3 1.1 2.1 1.8 3.2 1.6
Overall health rating 0.5 1.2 4.3 0.3 -1.1 0.5 -0.7 2.1 -0.8
Chest pain or discomfort 0.0 0.1 0.2 0.1 -0.2 -0.3 0.1 0.5 -0.2
Had major operations 1.0 1.2 4.8 -1.3 0.2 2.2 -0.7 0.2 0.5
Age at last live birth 0.8 1.2 2.6 -0.8 1.6 1.0 1.3 0.5 0.9
Family relationship satisfaction 0.3 0.4 0.9 0.8 0.6 0.8 0.1 0.1 1.0
Leg pain on walking 2.0 2.5 6.5 -2.0 0.7 -0.8 1.5 2.5 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 3.2 0.9 -0.2 1.8 0.2 0.2 0.2
Commuting to job workplace: Car/motor vehicle 0.4 0.5 2.2 0.3 -0.0 0.1 0.4 -1.5 0.6
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.0 -0.5 1.5 0.4 1.7 -0.6 0.6
Medication: Aspirin 0.3 0.4 0.9 -0.2 0.2 1.0 0.9 0.9 0.1
Supplements: Vitamin C 0.5 0.6 2.2 0.4 -0.4 1.5 -0.9 -0.4 0.2
Knee pain experienced in last month 0.8 1.3 4.2 -1.4 -0.3 -0.4 1.1 2.1 -0.0
Hypertension (Self-reported) 0.2 0.7 3.2 -0.2 -0.0 1.8 -0.2 0.8 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.3 -0.1 -0.2 0.0 -1.2 -1.5 0.3
Illnesses of father: Heart disease 1.4 1.9 5.6 -0.3 0.5 -2.4 2.3 0.1 0.7
Illnesses of siblings: Diabetes 2.8 3.4 8.2 1.6 -2.3 0.4 -1.9 -0.4 -2.9
Smoking status: Previous 0.1 0.2 0.9 1.0 0.4 -0.2 0.2 -0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 5.5 -1.6 1.1 0.9 2.3 0.5 1.3
Whole body fat-free mass 0.4 2.0 5.0 -1.3 0.5 -1.0 2.2 2.1 -0.4
Leg fat-free mass (right) 0.3 1.8 4.1 -0.1 -1.3 -1.7 0.7 1.3 -2.0
Arm fat percentage (left) 1.9 7.4 17.3 2.6 -4.2 -2.4 -1.6 -0.2 -3.5
Average weekly red wine intake 1.3 1.9 5.5 -0.9 1.4 0.0 1.8 0.2 2.3
Handedness (chirality/laterality): Left-handed 0.5 0.6 3.0 -0.5 0.5 -0.1 1.7 -0.3 0.3
Mood swings 0.2 0.3 1.2 0.3 0.1 -0.1 0.5 1.1 -0.3
Loneliness, isolation 1.9 2.6 5.7 0.7 -2.4 1.0 -1.8 1.7 -1.7
Long-standing illness, disability or infirmity 1.0 1.5 4.6 0.3 -1.3 -0.2 -0.2 1.6 -2.1
Ever had bowel cancer screening 0.6 0.7 2.0 -1.1 -1.0 -1.4 0.5 0.2 0.1
Diabetes diagnosed by doctor 1.7 2.7 6.4 1.9 -2.5 -0.7 0.2 -0.8 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.0 -0.1 -0.9 0.1 -0.1 -0.5 -1.0
Friendships satisfaction 0.7 0.8 1.6 -0.1 1.1 1.2 0.4 -0.8 1.2
Qualifications: nursing, teaching 1.1 1.7 3.7 -0.9 1.2 -1.9 1.3 -0.5 1.6
Commuting to job workplace: Walk 2.7 3.0 9.5 -1.7 0.9 1.2 1.0 3.1 1.4
Eye problems/disorders: Cataract 0.4 0.4 1.1 -0.3 -0.9 0.2 -0.8 -1.1 0.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.8 -0.5 0.0 -0.0 0.9 0.4 0.2
Medication for cholesterol 0.6 0.9 3.1 0.8 0.5 -1.0 -0.7 -1.8 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 6.7 0.3 -0.8 0.9 -2.6 -1.4 -1.1
Back pain experienced in last month 0.4 0.6 2.2 0.1 -0.8 1.5 0.7 0.6 0.0
Mineral and other dietary supplements 0.3 0.5 2.1 0.1 -0.5 0.5 1.4 0.1 0.4
Breast cancer (self-reported) 0.1 0.2 0.4 0.5 -0.3 -0.1 -0.3 -0.6 -0.3
Asthma (self-reported) 1.9 3.8 9.8 -1.6 0.0 3.1 1.6 2.8 0.1
Osteoporosis (self-reported) 0.5 0.6 1.6 0.9 0.8 -0.6 0.0 -1.3 0.5
Osteoarthritis (self-reported) 1.4 1.8 5.4 -0.4 -1.8 -2.3 -0.5 1.0 -0.9
Medication: Aspirin 0.5 0.6 1.6 -0.3 0.2 1.1 1.3 0.9 0.3
Medication: Gliclazide 1.1 1.2 3.4 0.2 -1.8 -0.6 -0.5 -0.4 -1.8
Illnesses of father: None of the above (group 1) 0.9 1.1 4.8 -0.2 2.2 1.1 0.0 0.2 0.8
Smoking status: Current 1.1 1.8 4.7 -2.2 -0.2 1.8 -0.0 1.5 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.4 -0.1 -0.9 -1.2 0.8 0.4 0.0
Whole body water mass 0.3 1.8 4.2 -1.2 0.5 -0.9 2.0 2.0 -0.4
Leg predicted mass (right) 0.3 1.8 4.0 -0.1 -1.2 -1.7 0.8 1.3 -2.0
Arm fat mass (left) 0.9 3.6 8.1 1.7 -2.8 -1.8 -0.6 0.7 -2.6
Number of self-reported non-cancer illnesses 1.6 2.7 5.0 0.8 -2.1 1.2 -0.2 2.2 -2.2
Average weekly champagne plus white wine intake 0.7 1.0 2.2 -0.4 0.2 -1.2 1.0 -1.0 1.5
Miserableness 1.7 2.9 15.0 -0.0 -0.5 0.9 0.7 3.9 -1.0
Guilty feelings 1.1 1.7 5.6 1.1 -0.4 -0.4 -2.4 -1.5 -0.8
Wears glasses or contact lenses 0.9 1.0 3.3 0.9 -0.3 -1.2 -0.3 -0.6 -1.8
Ever taken oral contraceptive pill 1.3 1.5 3.7 -1.9 1.3 0.7 0.7 0.8 1.3
Hearing aid user 0.5 0.5 2.3 0.2 1.5 -0.7 -0.4 -0.5 0.1
Mother’s age at death 0.4 0.5 1.1 -0.8 0.8 -0.3 -0.2 -1.1 0.6
Financial situation satisfaction 2.5 3.1 9.9 1.0 -3.1 -1.1 -0.8 0.3 -2.4
Tinnitus: Yes, now most or all of the time 1.7 2.0 5.6 0.5 -2.4 1.9 -1.3 -0.8 -0.7
Commuting to job workplace: Public transport 0.4 0.5 1.6 0.3 -0.1 0.7 -1.3 0.1 -0.8
Eye problems/disorders: Glaucoma 0.9 1.0 2.4 -1.5 -0.1 -1.0 1.2 0.5 1.1
Medication: Blood pressure 0.6 1.2 2.3 -1.5 0.7 0.8 0.8 1.2 1.4
Pain type(s) experienced in last month: Hip pain 0.8 1.1 5.1 -0.6 0.4 0.2 0.8 2.3 0.2
Supplements: Fish oil (including cod liver oil) 1.3 1.7 4.6 -1.6 2.1 0.3 0.2 0.5 1.6
High cholesterol (Self-reported) 1.7 3.0 6.7 2.6 -2.3 -1.6 -0.2 -0.2 -1.8
Medication: Bendroflumethiazide 0.9 1.4 2.5 0.5 1.1 0.7 1.6 1.2 1.5
Medication: Paracetamol 0.8 1.2 2.8 0.1 -1.0 1.4 -0.5 1.7 -1.1
Medication: Lisinopril 0.4 0.6 1.2 -1.0 0.8 0.1 0.2 0.6 1.1
Medication: Atorvastatin 0.8 1.0 3.1 1.8 -1.1 -0.1 0.1 0.3 -1.4
Illnesses of father: High blood pressure 0.4 0.4 1.7 0.1 -1.3 0.2 -0.6 -0.5 -0.5
Alcohol drinker status: Never 0.6 0.7 2.3 -0.5 0.7 -0.9 1.5 0.7 0.1
Ever smoked 0.1 0.2 0.6 0.7 0.3 0.0 -0.3 -0.2 -0.8
Basal metabolic rate 0.3 1.6 4.0 -0.8 -0.1 -1.1 1.8 2.0 -0.7
Leg fat percentage (left) 0.9 3.2 9.1 1.6 -3.0 -1.6 -0.9 0.2 -2.0
Arm fat-free mass (left) 0.4 1.9 4.3 -1.5 1.1 -0.4 1.9 2.1 0.2
Number of operations (self-reported) 0.3 0.4 1.4 -0.2 -0.6 -1.2 -0.1 -0.0 -0.9
Average weekly beer plus cider intake 2.0 3.0 5.9 -2.1 0.6 2.4 0.9 2.0 1.4
Irritability 0.5 0.9 3.9 0.6 -0.1 1.0 0.2 2.0 -0.1
Risk taking 0.4 0.6 1.8 1.3 -0.4 0.4 0.4 -0.9 -0.6
Ever had prostate specific antigen (PSA) test 1.5 1.8 4.2 -1.9 1.2 0.3 2.0 0.2 1.1
Fractured/broken bones in last 5 years 0.5 0.6 1.2 -1.1 0.6 0.0 0.8 0.9 0.8
Age started oral contraceptive pill 1.1 1.4 4.7 -1.1 2.2 -0.3 0.4 -0.1 1.4
Diastolic blood pressure, automated reading 0.2 0.7 2.3 0.1 1.5 -0.1 0.7 -1.1 0.7
Ever depressed for a whole week 1.0 1.2 2.3 1.0 -1.5 1.3 -0.6 0.9 -1.2
Unable to work because of sickness or disability 0.3 0.4 1.4 0.4 -0.6 0.1 -0.6 1.2 -0.2
Commuting to job workplace: Cycle 0.3 0.3 1.1 0.5 1.1 -0.0 -0.1 0.6 -0.6
Myopia 0.6 0.8 3.5 -0.1 1.9 -0.5 -0.1 -0.6 1.0
Vascular/heart problems diagnosed by doctor 0.4 1.0 3.9 0.2 0.0 -2.0 -0.3 -1.3 -0.4
Cholesterol lowering medication 1.3 1.9 6.3 -0.3 -2.5 0.6 0.3 1.9 -1.1
Medication: Omeprazole (e.g. Zanprol) 1.9 2.4 5.3 1.4 -1.7 -2.3 -0.7 -0.2 -1.9
Pain experienced in last month 0.5 0.8 2.2 -0.6 1.5 -0.1 0.8 -0.0 1.3
Supplements: Calcium 0.5 0.5 2.1 -0.1 0.8 1.5 0.0 0.5 -0.4
Basal cell carcinoma (self-reported) 0.5 0.6 1.1 0.7 0.2 1.0 0.4 1.0 -1.0
Heart attack/myocardial infarction (self-reported) 1.1 1.5 4.7 -1.0 1.0 0.4 2.2 1.2 0.7
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.2 1.5 -1.0 0.3 -0.8 1.2 -0.9
Heart disease (siblings) 0.3 0.3 0.7 -0.6 -0.8 -0.1 -0.8 -0.4 0.1
Alcohol drinker status: Previous 0.4 0.5 1.7 0.6 -0.0 0.2 -1.3 -0.8 -0.1
Pack years of smoking 0.8 1.2 2.2 -1.0 -1.4 -0.6 -0.1 1.2 -1.5
Impedance of whole body 0.4 2.3 7.1 0.9 0.2 2.7 -0.3 -1.4 1.9
Leg fat mass (left) 1.0 3.9 10.3 1.7 -3.2 -1.5 -0.9 0.3 -2.6
Arm predicted mass (left) 0.4 2.1 4.2 -1.6 1.3 -0.6 2.0 2.1 0.3