Hub : Genes

BANK1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0820	0.0360	0.00880	0.006	NA	0.004	NA	0.004	9.3e-02	NA	0.15000	NA	1.4e-01
2	GTEx	Adipose Visceral Omentum	0.1940	0.0650	0.00150	0.063	NA	0.070	NA	0.075	3.4e-04	NA	0.00017	NA	9.9e-05
3	GTEx	Brain Nucleus accumbens basal ganglia	0.2690	0.0970	0.00300	-0.011	NA	-0.011	NA	-0.002	9.4e-01	NA	0.94000	NA	3.7e-01
4	METSIM	Adipose	0.0436	0.0182	0.00160	0.035	0.011	0.021	0	0.027	4.4e-06	0.0076	0.00035	0.34	5.5e-05
5	TCGA	Prostate Adenocarcinoma	0.0448	0.0187	0.00031	0.016	0.023	0.006	NA	0.017	8.0e-03	0.0017	0.06600	NA	6.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.2	0.4	0.5	0.1	0.5	0.3	-0.6
Bipolar Disorder or Schizophrenia	0.5	1.1	2.2	-1.4	-1.1	0.1	-0.5	1.5
Depressed Affect (Nagel 2018)	1.0	2.1	3.5	-1.9	-1.0	-1.8	-1.7	-0.1
Depression (Nagel 2018)	1.7	2.5	5.5	-2.4	-1.3	-2.0	-1.0	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.7	1.9	1.4	0.4	0.8	-1.3
Neuroticism (Nagel 2018)	0.4	1.0	2.2	-1.2	-0.2	-1.5	-1.0	0.4
Schizophrenia (2018)	1.3	2.8	5.7	-2.3	-1.5	-0.3	-0.8	2.4
Schizophrenia vs Biploar Disorder	2.3	3.1	7.4	-2.3	-1.5	-0.2	-0.8	2.7
Worry (Nagel 2018)	0.3	0.6	1.1	-1.0	-0.1	-1.0	-0.8	0.5
Alzheimer’s Disease (in mother)	1.4	1.7	3.5	1.9	1.9	0.1	0.9	-0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.3	0.8	0.2	0.3	0.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.1	1.0	1.1	0.3	0.3	-0.5
Crohns Disease (2017)	1.2	2.6	8.0	-1.5	-0.6	-0.4	-1.6	2.8
Irritable Bowel Disease (IBD)	1.3	3.1	6.0	-2.4	-0.5	-1.3	-1.3	2.4
Ulcerative Colitis (UC)	1.1	2.1	5.3	-2.3	-0.2	-1.8	-0.4	1.3
Major Depression (MDD)	0.4	0.4	0.9	0.6	0.8	0.4	0.2	-1.0
Reaction Time	0.4	0.8	1.5	1.1	0.6	1.2	0.9	0.1
Verbal and Numeric Reasoning (VNR)	1.0	2.4	6.1	2.5	0.4	1.7	0.0	-1.8
Breast Cancer	0.3	0.8	1.9	-0.5	1.0	-0.2	1.4	-0.7
Ovarian Cancer	1.2	1.6	4.8	0.5	-1.2	0.7	-2.2	-0.8
Prostate Cancer	0.6	0.9	3.2	0.9	0.1	-0.5	-0.5	-1.8
Age at First Birth	0.5	0.7	1.9	-0.7	-1.4	-1.0	-0.2	0.2
Bipolar Disorder (2011)	1.5	1.5	3.3	-1.4	-1.8	-0.2	-1.0	0.9
Body Mass Index (BMI) (2010)	1.6	2.3	4.5	-1.8	-1.7	-0.1	-0.8	2.1
Coronary Artery Disease (CAD)	0.9	1.0	2.5	-1.1	-0.2	0.3	1.6	-1.2
Crohns Disease (2012)	1.1	1.8	5.7	-1.4	0.2	-1.1	-0.4	2.4
Mean Putamen Volume	0.4	0.4	1.7	-0.6	-0.1	1.3	0.2	0.1
Fasting Glucose	0.2	0.2	0.3	-0.5	-0.4	0.6	0.2	0.4
HbA1C	1.4	1.6	3.3	-0.2	-1.1	1.8	-0.5	-1.7
HDL Cholesterol	1.6	2.7	7.1	1.5	-0.1	1.4	-1.5	-2.7
LDL Cholesterol	0.7	1.2	2.6	0.4	1.4	-0.8	1.6	-0.6
Lupus	5.3	8.0	26.7	3.1	1.0	1.6	-0.1	-5.2
Neuroticism (2016)	0.6	0.9	2.8	-1.2	0.2	-1.7	-0.4	-0.2
Primary Biliary Cirrhosis	0.5	0.7	1.3	-1.1	-0.6	1.1	0.3	-0.7
Rheumatoid Arthritis	1.3	1.8	4.0	1.8	0.6	1.3	0.0	-2.0
Schizophrenia (2014)	2.2	4.9	12.8	-3.0	-1.1	-1.2	0.2	3.6
Triglycerides	0.5	0.7	1.6	-1.2	0.0	-0.7	0.5	1.2
Type 2 Diabetes (T2D) (2012)	2.7	3.1	5.6	2.0	1.9	2.4	1.6	-0.2
Ulcerative Colitis	1.2	1.7	3.3	-1.8	0.4	-1.6	0.2	1.7
Blood Eosinophil Count	0.8	5.9	17.5	1.3	1.9	4.2	2.6	-0.2
Blood Platelet Count	0.6	6.4	19.8	-2.1	-0.2	-2.8	0.5	4.5
Blood Red Count	0.3	3.3	11.9	-1.7	0.1	-1.3	0.5	3.5
Blood White Count	0.2	1.8	6.7	-1.4	-0.0	-0.5	0.3	2.6
Heel T-Score	0.2	1.8	3.8	0.9	1.4	1.5	1.9	-0.6
BMI	1.9	10.8	21.8	-4.7	-1.7	-4.0	-1.1	3.5
Height	0.5	10.5	27.7	3.0	2.1	2.8	1.8	-5.3
Waist Hip Ratio (WHR)	1.0	4.7	12.0	3.5	2.2	2.3	0.8	-0.8
Systolic Blood Pressure	3.1	15.6	22.9	4.4	4.3	2.5	3.4	-4.8
Smoking Status	1.2	2.8	6.2	2.2	1.3	0.9	0.1	-2.5
Allergy or Eczema	0.6	1.5	4.1	-1.2	-0.4	-1.2	-0.7	2.0
Cardiovascular Disease	4.4	14.4	24.9	3.6	3.3	5.0	3.1	-3.7
Hypothyroidism (self reported)	3.8	8.7	17.3	3.6	1.8	4.2	0.5	-3.1
Respiratory disease	0.3	0.6	2.2	-0.1	-0.3	-0.8	-0.5	-1.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.4	-0.3	-1.2	1.1	-0.7	1.0
Lung FEV1/FVC ratio	0.5	2.8	8.4	0.0	-1.2	1.9	-2.9	-0.7
Lung FVC	0.8	3.9	8.4	-1.8	-0.4	-2.9	-0.6	2.7
Neuroticism	0.3	0.7	2.6	-0.4	0.4	-1.6	-0.7	0.4
Chronotype (morning person)	0.4	0.9	1.9	0.2	-1.2	-0.7	-0.8	-1.4
Hair Pigment	0.1	1.6	2.5	1.6	1.4	-0.8	1.6	0.8
Tanning	0.0	0.5	1.5	-0.6	0.4	0.5	1.2	0.6
Hand grip strength (left)	4.1	10.9	25.8	5.1	1.7	2.2	-0.2	-4.6
Number of treatments/medications taken	0.4	0.8	2.1	0.0	0.4	1.5	1.3	-0.3
Average weekly spirits intake	0.3	0.3	0.7	-0.4	0.1	0.8	-0.2	-0.8
Sensitivity / hurt feelings	2.0	3.4	9.7	-1.2	0.8	-2.2	0.5	3.1
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.0	-2.0	-1.1	-1.6	-0.6	0.8
Hearing difficulty/problems: Yes	0.4	0.6	1.2	-0.9	-0.7	0.4	-0.4	1.1
Relative age of first facial hair	1.5	3.1	7.0	2.3	2.6	-0.8	1.3	1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.8	-1.7	-0.1	0.6	0.6	-0.6
Ever used hormone-replacement therapy (HRT)	2.4	3.0	7.3	-1.1	-2.3	0.9	-2.7	-0.9
Ever had hysterectomy (womb removed)	1.1	1.2	3.1	-1.7	-0.6	-0.1	-0.4	1.6
Systolic blood pressure, automated reading	1.3	3.9	8.6	2.6	1.8	0.9	0.2	-2.9
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	3.2	-1.8	-0.3	-1.1	0.3	1.3
Angina	1.1	1.5	6.3	0.2	0.2	0.6	0.8	-2.5
Medication for hormone replacement therapy	0.4	0.5	0.9	-0.5	1.0	0.0	0.6	-0.9
Vitamin and mineral supplements	0.4	0.5	2.3	0.4	0.3	0.1	-0.2	-1.5
Supplements: Zinc	0.3	0.3	1.0	-1.0	-0.3	-0.6	-0.1	-0.2
Medication: Co-codamol	1.5	1.7	2.6	1.1	1.6	0.8	1.6	-1.2
Medication: Metformin	0.2	0.3	0.7	-0.4	0.4	-0.2	0.8	0.6
Diabetes (father)	0.4	0.5	1.0	0.6	0.8	0.1	-1.0	-0.8
Diabetes (mother)	0.4	0.6	1.1	-0.4	-0.6	1.1	-0.5	0.9
Severe depression (siblings)	0.6	0.6	2.2	-0.3	-0.7	0.4	-1.5	0.6
Pack years adult smoking proportion	0.6	1.0	2.6	0.6	1.6	-0.4	1.2	-0.5
Impedance of leg (right)	1.5	7.2	17.3	3.8	0.8	4.2	0.1	-1.8
Leg fat-free mass (left)	0.7	3.9	9.3	-3.0	-0.7	-3.0	0.2	1.0
Trunk fat percentage	1.9	7.5	16.5	-4.1	-1.5	-2.8	-0.9	3.2
Hand grip strength (right)	2.8	7.7	17.9	4.2	0.6	2.6	-0.5	-3.7
Townsend deprivation index at recruitment	0.1	0.2	0.8	-0.9	0.0	-0.0	-0.1	-0.3
Current tobacco smoking	1.0	1.6	3.8	1.5	2.0	0.3	1.1	-0.5
Average weekly fortified wine intake	0.4	0.5	0.9	0.3	0.5	-0.8	1.0	0.6
Maternal smoking around birth	0.7	1.0	2.3	0.6	0.9	-1.1	-0.5	-1.5
Fed-up feelings	0.4	0.8	2.2	-0.9	-0.2	-1.5	-0.9	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.3	-0.7	-0.4	-0.3	-1.0	-1.1
Relative age voice broke	0.3	0.4	1.7	-0.3	0.3	-0.3	0.3	1.3
Taking other prescription medications	0.5	0.8	2.5	-1.6	0.3	0.3	1.2	-0.2
Age when periods started (menarche)	4.0	9.7	21.4	-2.7	0.7	-3.3	2.9	4.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.2	0.4	-0.2	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.3	0.9	0.6	0.1	1.2	0.6
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	6.6	-1.2	-0.5	-2.6	0.2	0.8
Qualifications: CSEs or equivalent	0.7	0.9	2.0	-1.1	-1.4	-0.4	-0.7	0.7
Serious illness, injury or assault to yourself	1.9	2.3	3.5	-1.3	-1.9	1.8	-1.4	1.1
High blood pressure	2.8	7.8	12.2	2.2	2.9	3.5	2.2	-2.9
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.0	-1.1	-0.4	-1.6	-0.9	1.7
Multivitamins +/- minerals	0.1	0.2	0.7	-0.0	0.2	-0.3	0.3	0.8
Stomach or abdominal pain in last month	0.7	0.9	2.1	-1.5	-0.4	0.6	0.1	1.2
Supplements: Glucosamine	1.4	1.9	6.0	-2.5	-0.5	-0.4	0.7	1.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	4.5	0.3	-0.5	0.4	-1.5	-2.1
Medication: Atenolol	1.1	1.4	3.7	1.0	0.2	1.4	0.8	-1.9
Medication: Levothyroxine sodium	1.4	2.4	5.9	1.5	0.5	2.4	0.5	-1.9
Sitting height	0.4	3.0	7.9	-2.8	-1.2	-1.9	-0.1	1.3
Chronic bronchitis/emphysema (father)	0.5	0.6	2.1	-0.5	-0.5	-0.1	0.4	1.5
High blood pressure (mother)	1.1	1.5	3.2	1.8	1.0	1.1	-0.2	-1.5
Body mass index (BMI)	1.8	7.5	18.2	-4.3	-1.6	-3.3	-0.8	2.3
Impedance of leg (left)	1.7	8.0	18.1	4.1	1.3	4.3	0.3	-1.8
Leg predicted mass (left)	0.8	4.0	9.5	-3.1	-0.6	-3.0	0.3	1.0
Trunk fat mass	1.4	6.1	14.2	-3.8	-1.2	-2.9	-0.6	2.5
Waist circumference	0.7	2.4	6.2	-2.5	-0.4	-1.9	-0.2	1.5
Number of incorrect matches in round	0.4	0.6	1.2	-1.0	0.6	-0.3	0.6	-1.1
Past tobacco smoking	0.5	1.0	2.8	0.1	-0.0	1.7	0.2	1.4
Alcohol usually taken with meals	0.3	0.5	0.9	0.7	-0.5	0.6	-0.6	0.9
Nervous feelings	0.2	0.3	1.0	-1.0	0.6	-0.2	0.0	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.5	-0.7	0.2	-0.4	0.1	0.6
Hearing difficulty/problems with background noise	0.5	0.8	1.8	-1.4	0.1	-0.7	0.3	1.3
Hair/balding pattern: Pattern 2	1.0	1.3	2.3	-0.8	-1.5	1.5	-1.1	-0.3
Had menopause	1.1	1.3	3.1	-1.1	-1.8	-0.0	-1.5	0.4
Had other major operations	0.7	0.9	2.7	1.0	0.3	-0.3	-0.7	-1.6
Forced vital capacity (FVC)	0.1	0.5	1.8	-0.0	-0.3	-1.4	-0.4	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.7	1.4	1.5	-0.3	1.9	0.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.2	-0.6	-0.7	-0.1	-1.5	1.0
Qualifications: None of the above	1.0	2.2	7.0	-1.7	-0.5	-0.8	-0.6	-2.6
Financial difficulties in last 2 years	1.2	1.6	4.8	-0.9	0.5	-2.2	-0.3	1.5
Mouth/teeth dental problems	0.9	1.4	3.2	1.0	1.2	-0.7	0.9	1.8
Heart attack	0.2	0.3	1.1	0.3	0.1	-0.3	0.4	-1.1
Allergy	0.8	1.9	5.1	1.1	-0.1	2.3	-0.0	-1.7
Pain all over the body in last month	1.4	1.6	4.0	-1.2	1.0	-1.1	2.0	0.1
Diabetes (self-reported)	0.2	0.4	0.7	-0.8	-0.4	0.6	0.4	0.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.1	1.5	1.0	0.4	-0.6	-0.9
Medication: Ramipril	3.5	4.5	8.9	2.4	2.0	3.0	1.9	0.6
Medication: Simvastatin	0.6	0.9	2.6	1.6	0.3	1.2	0.0	-0.8
Fluid intelligence score	1.2	2.6	6.2	1.8	0.1	1.8	-0.1	-2.5
Illnesses of siblings	0.3	0.5	1.3	1.1	0.0	-0.1	0.2	1.0
Neuroticism score	0.4	0.9	2.5	-0.7	-0.3	-1.6	-1.1	0.1
Weight	0.8	4.1	11.8	-3.4	-0.9	-2.5	-0.2	1.1
Impedance of arm (right)	0.3	1.2	2.2	1.5	0.3	1.5	-0.4	1.2
Arm fat percentage (right)	2.1	8.2	17.7	-4.2	-1.6	-3.3	-1.1	2.9
Trunk fat-free mass	0.1	0.8	1.8	-0.9	0.0	-1.2	0.4	-1.3
Hip circumference	1.8	7.7	18.3	-4.3	-2.0	-3.0	-0.9	2.5
Time employed in main current job	0.4	0.5	1.4	-1.2	0.6	-0.2	0.8	-0.3
Alcohol intake versus 10 years previously	0.2	0.4	1.0	-1.0	-0.6	0.5	-0.2	0.4
Father’s age at death	0.4	0.5	2.0	0.6	-0.1	1.4	-0.6	0.1
Worrier / anxious feelings	1.2	2.2	7.7	-1.0	-0.7	-2.8	-1.0	0.9
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	8.3	-2.6	-0.0	-2.9	0.2	1.0
Falls in the last year	0.7	1.0	2.7	-1.6	-0.1	1.3	0.3	0.5
Hair/balding pattern: Pattern 3	1.2	1.7	5.1	0.9	2.3	0.6	1.5	-0.4
Number of live births	1.0	1.4	4.7	-0.9	0.8	-0.6	2.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.7	-0.4	-0.6	-0.8	-0.7	0.5
Pulse rate	0.8	1.4	2.8	-1.1	0.9	-1.7	1.2	0.8
Happiness	2.1	2.5	5.6	-0.1	2.4	-2.2	1.5	0.2
Noisy workplace	0.4	0.5	1.6	-0.9	-1.2	0.0	0.2	0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.5	-0.8	-1.3	-0.1	-1.6	-0.5
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	3.9	-1.8	-2.0	0.1	-1.3	1.3
Mouth/teeth dental problems: Dentures	0.3	0.6	1.4	0.8	-0.1	0.4	-0.8	-1.2
Asthma	0.6	1.2	5.5	-0.7	0.4	-2.3	0.2	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.5	2.0	4.3	-2.1	-2.1	0.3	-0.9	0.6
Medication: Cholesterol lowering	0.6	1.0	2.2	1.5	-0.0	0.8	-0.3	-1.4
Depression (self-reported)	0.5	0.6	1.6	0.0	0.2	1.3	-0.4	-1.0
Medication: Lansoprazole	0.8	0.9	1.6	-1.3	-1.3	0.2	-1.1	-0.2
Prospective memory result	3.3	4.1	9.4	-2.5	-0.1	-3.1	0.8	2.1
Lung cancer (father)	0.5	0.6	1.7	-0.9	0.4	-1.3	0.1	0.2
Illnesses of mother	0.5	0.6	2.4	-0.2	0.2	-1.5	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.0	-0.4	0.1	-1.0	-0.3	1.0
Pulse wave Arterial Stiffness index	1.5	1.8	3.2	-1.2	1.2	-0.4	1.6	1.8
Impedance of arm (left)	0.3	1.4	2.9	1.7	0.2	1.7	-0.6	0.8
Arm fat mass (right)	1.7	6.9	16.3	-4.0	-1.5	-3.2	-0.8	2.3
Trunk predicted mass	0.1	0.8	1.8	-0.9	-0.0	-1.2	0.3	-1.3
Standing height	0.2	1.8	4.2	1.2	1.0	1.2	1.0	-2.0
Length of working week for main job	0.6	0.6	2.1	1.5	0.3	0.9	-0.2	-0.2
Exposure to tobacco smoke at home	0.6	0.7	2.4	-0.1	-0.3	1.6	-0.9	0.3
Breastfed as a baby	0.9	1.1	3.2	0.1	-1.4	0.6	-0.1	1.8
Tense / ‘highly strung’	0.6	1.0	2.9	0.0	0.7	-1.7	-0.5	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	-0.4	-0.6	0.1	-1.1	-1.1
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	0.4	1.0	-0.3	1.2	0.5
Birth weight of first child	0.3	0.5	0.9	-0.2	0.6	-0.7	1.0	0.7
Peak expiratory flow (PEF)	0.4	0.8	2.0	-0.6	-1.4	-0.2	-1.3	-0.1
Pulse wave reflection index	0.5	0.7	2.5	0.6	0.5	1.6	0.3	0.3
Ever highly irritable/argumentative for 2 days	0.6	0.7	3.1	-0.0	0.4	-1.8	-0.1	0.7
Loud music exposure frequency	0.4	0.5	1.6	1.3	-0.0	0.9	-0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.6	0.3	-0.5	0.1	0.3	1.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.9	-2.0	-1.3	-1.3	-0.8	-0.5
Blood clot in the leg (DVT)	0.2	0.3	1.0	0.4	-0.2	-1.0	0.2	0.2
Medication: Paracetamol	0.9	1.5	4.6	-2.1	-1.5	0.0	0.1	0.8
Headache pain in last month	0.3	0.5	1.3	-0.4	-0.2	-1.2	-0.8	0.4
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.8	-1.6	-1.3	-2.2	-1.4	0.9
Glaucoma (self-reported)	0.4	0.5	0.9	-0.9	-0.1	-0.9	0.3	0.8
Gout (self-reported)	1.2	1.6	3.8	1.9	1.0	0.8	0.4	-1.6
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	9.1	2.2	1.0	3.0	0.6	-2.1
Medication: Amlodipine	1.0	1.5	5.8	0.8	0.7	2.4	0.5	-0.4
Medication: Ventolin 100micrograms inhaler	1.5	1.9	5.1	-2.3	0.1	-1.3	1.5	0.8
Birth weight	0.1	0.2	0.3	-0.1	0.4	-0.5	0.5	0.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.8	0.8	1.2	1.2	1.7	-0.5
High blood pressure (siblings)	0.4	0.5	1.6	-0.9	-0.1	-0.2	-0.1	-1.3
Forced vital capacity (FVC), Best measure	0.2	0.6	1.6	-0.2	0.2	-1.3	0.3	1.0
Body fat percentage	1.6	6.2	13.8	-3.7	-1.5	-2.5	-1.0	2.8
Leg fat percentage (right)	0.8	3.0	6.6	-2.6	-1.2	-1.7	-1.1	1.8
Arm fat-free mass (right)	0.3	1.4	3.7	-1.9	-0.4	-1.6	0.4	-0.7
Exposure to tobacco smoke outside home	0.5	0.6	2.4	-1.5	0.3	-0.7	0.3	0.0
Comparative body size at age 10	1.0	2.8	5.5	-1.1	-1.8	-1.6	-2.4	1.3
Number of full brothers	0.2	0.3	1.0	-1.0	-0.5	-0.3	0.0	0.3
Worry too long after embarrassment	0.7	1.2	3.0	0.4	0.8	-1.7	0.5	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	7.7	0.9	-0.1	1.0	-0.8	-2.8
Wheeze or whistling in the chest in last year	1.0	1.8	3.9	-2.0	0.1	-1.3	1.3	1.3
Number of children fathered	1.0	1.2	4.8	0.9	0.1	2.2	-0.0	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.5	0.6	-0.3	0.8	-1.6	-1.9
Age at first live birth	0.6	1.1	3.2	-0.1	0.0	-1.8	0.5	1.4
Pulse wave peak to peak time	1.6	1.9	3.9	1.4	-1.1	0.5	-1.5	-2.0
Health satisfaction	3.1	4.0	7.4	-2.4	0.6	-2.7	1.8	1.7
Shortness of breath walking on level ground	1.2	1.5	3.4	-1.3	0.5	-1.9	1.3	-0.5
Qualifications: College or University degree	0.3	1.0	2.8	1.2	0.3	1.7	-0.7	-0.0
Eye problems/disorders: None of the above	1.5	1.7	5.2	0.7	-0.8	2.3	0.1	-1.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.0	-0.0	-0.1	-1.0	-0.4	-0.2
Emphysema/chronic bronchitis	1.5	1.6	4.1	1.8	0.3	-0.5	-0.7	-2.0
Medication for pain relief, constipation, heartburn	1.4	2.4	4.6	2.1	2.2	0.2	0.4	-1.5
Neck or shoulder pain in last month	1.0	1.4	5.0	-2.2	-0.7	-1.0	-0.4	0.6
Medication: Blood pressure	2.0	3.5	6.2	1.0	2.3	2.2	2.5	-0.3
Angina (self-reported)	1.0	1.3	4.9	0.2	0.4	0.5	1.1	-2.2
Migraine (self-reported)	1.3	1.6	4.1	1.0	2.0	-1.5	0.9	0.3
Medication: Ibuprofen	1.3	1.6	4.1	-1.6	-2.0	0.8	-0.7	0.2
Medication: Allopurinol	2.4	3.1	5.4	2.3	1.2	1.9	0.4	-2.3
Medication: Omeprazole	0.9	1.1	2.3	-0.2	-1.2	-0.9	-1.5	-0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.3	-1.1	-0.5	-0.2	0.5	0.7
Mean time to correctly identify matches	0.3	0.5	1.0	0.6	0.6	0.1	1.0	0.9
Heart disease (mother)	0.9	1.1	4.1	-2.0	-0.9	-0.0	0.2	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.8	1.7	1.1	-0.0	0.8	-0.3
Whole body fat mass	1.4	5.7	13.2	-3.6	-1.2	-2.8	-0.6	2.3
Leg fat mass (right)	0.9	3.3	8.9	-3.0	-0.9	-2.2	-0.5	1.3
Arm predicted mass (right)	0.3	1.3	3.8	-2.0	-0.3	-1.4	0.4	-0.6
Pulse rate, automated reading	0.1	0.2	0.8	-0.5	-0.2	-0.1	-0.9	-0.1
Alcohol intake frequency.	0.4	0.8	1.9	-1.1	-0.8	-0.7	-0.0	1.4
Comparative height size at age 10	1.0	5.7	15.5	2.2	-0.3	2.8	-0.4	-3.9
Number of full sisters	1.3	1.6	4.6	-2.1	-1.6	0.1	-0.4	0.6
Suffer from ‘nerves’	0.3	0.5	1.1	-1.1	0.4	-1.0	-0.2	0.7
Overall health rating	1.0	2.2	7.1	-2.7	-1.2	-1.6	-0.1	-0.4
Chest pain or discomfort	0.9	1.3	3.0	0.3	1.7	-1.2	1.4	-0.1
Had major operations	0.6	0.8	3.6	-0.0	-0.4	-0.2	-0.2	-1.9
Age at last live birth	0.9	1.3	2.4	-1.5	0.2	-1.4	0.9	1.1
Family relationship satisfaction	1.6	1.9	5.2	1.0	1.7	-2.3	0.8	-0.1
Leg pain on walking	3.1	3.9	10.9	-2.6	-0.3	-3.3	1.1	0.9
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	11.1	-1.1	-0.4	-0.4	0.7	3.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.7	0.7	1.0	0.3	1.2	1.6
Illness, injury, bereavement, stress in last 2 years	2.4	3.0	6.7	2.6	2.2	0.7	0.9	-1.3
Medication: Aspirin	0.4	0.5	1.2	-0.2	0.3	-1.0	1.1	-0.4
Supplements: Vitamin C	0.2	0.2	0.4	-0.5	0.3	-0.4	0.4	0.6
Knee pain experienced in last month	1.7	2.6	6.5	-2.6	1.0	-1.4	1.0	1.5
Hypertension (Self-reported)	3.3	9.2	13.9	2.5	3.1	3.7	2.2	-3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	0.3	-0.2	-0.6	-0.9	-0.4
Illnesses of father: Heart disease	1.6	2.2	5.0	-2.2	-0.3	-0.6	0.8	2.2
Illnesses of siblings: Diabetes	1.1	1.3	4.6	-2.2	-1.3	0.4	0.3	0.4
Smoking status: Previous	0.5	0.7	2.8	-0.2	0.1	-1.7	-0.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.0	1.4	0.9	0.1	1.1	-1.1
Whole body fat-free mass	0.3	1.7	4.5	-1.9	-0.1	-2.1	0.5	-0.3
Leg fat-free mass (right)	0.7	3.7	8.9	-3.0	-0.5	-2.9	0.4	0.9
Arm fat percentage (left)	1.9	7.7	16.7	-4.1	-1.8	-3.0	-1.4	2.7
Average weekly red wine intake	2.3	3.4	6.4	1.6	2.5	0.1	2.4	1.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.0	-0.8	-1.4	-0.1	-0.8	0.4
Mood swings	0.6	1.1	2.0	-1.0	-0.5	-1.1	-1.1	-1.4
Loneliness, isolation	1.5	2.1	5.0	-2.2	-1.9	0.9	-1.0	0.1
Long-standing illness, disability or infirmity	1.4	2.2	9.1	-3.0	-0.6	-0.5	0.3	1.1
Ever had bowel cancer screening	1.1	1.3	3.0	0.1	-1.1	1.7	-1.0	-1.2
Diabetes diagnosed by doctor	0.4	0.7	1.6	-1.2	-0.9	0.2	0.2	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.9	-1.1	-1.2	1.4	-0.7	-0.8
Friendships satisfaction	1.4	1.7	4.3	0.2	1.4	-2.1	0.5	1.4
Qualifications: nursing, teaching	0.1	0.1	0.2	0.5	0.5	-0.2	-0.0	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	-0.5	0.2	-0.2	-0.2
Eye problems/disorders: Cataract	1.0	1.2	4.0	0.1	0.3	-1.2	-0.6	2.0
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.8	0.6	-0.6	1.9	-0.9	-1.3
Medication for cholesterol	1.6	2.4	4.4	-0.9	-1.4	-2.1	-0.9	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.3	3.8	8.3	-1.5	-2.7	0.4	-2.9	-1.1
Back pain experienced in last month	2.0	2.9	8.4	-2.9	-1.9	-1.4	-0.5	0.7
Mineral and other dietary supplements	0.2	0.3	0.6	0.6	0.8	-0.8	0.1	-0.2
Breast cancer (self-reported)	0.5	0.6	1.4	1.2	0.9	0.5	0.2	-0.8
Asthma (self-reported)	0.5	1.0	4.5	-0.7	0.3	-2.1	0.2	-0.1
Osteoporosis (self-reported)	0.2	0.3	1.0	-1.0	-0.1	0.3	-0.0	-0.6
Osteoarthritis (self-reported)	1.7	2.3	5.3	-2.3	-0.9	-0.6	-0.1	2.2
Medication: Aspirin	0.5	0.6	1.4	-0.7	-0.1	-1.2	1.0	-0.4
Medication: Gliclazide	0.5	0.5	1.2	-0.4	0.6	-0.6	1.1	0.7
Illnesses of father: None of the above (group 1)	1.0	1.2	4.5	2.1	1.1	0.2	-0.1	-0.6
Smoking status: Current	0.7	1.1	2.5	1.4	1.6	0.2	0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	5.4	-2.1	-1.9	-1.1	-1.1	2.3
Whole body water mass	0.3	1.7	4.5	-2.0	-0.3	-2.1	0.4	-0.4
Leg predicted mass (right)	0.7	3.8	9.2	-3.0	-0.5	-3.0	0.3	0.8
Arm fat mass (left)	1.5	6.0	13.8	-3.7	-1.3	-3.2	-0.8	1.9
Number of self-reported non-cancer illnesses	0.8	1.3	3.3	0.4	1.0	1.8	0.7	-1.2
Average weekly champagne plus white wine intake	1.6	2.3	4.1	0.1	-2.0	1.4	-1.6	-1.6
Miserableness	0.2	0.4	1.1	-0.0	1.1	-0.8	-0.5	0.0
Guilty feelings	0.4	0.6	2.0	0.8	0.4	0.2	-0.3	-1.4
Wears glasses or contact lenses	4.0	4.6	13.3	-3.6	-1.0	-1.0	-0.1	2.8
Ever taken oral contraceptive pill	2.8	3.1	5.2	0.8	-2.3	1.5	-2.2	-1.6
Hearing aid user	2.2	2.4	4.3	0.4	-1.4	1.9	-2.1	-1.5
Mother’s age at death	0.9	1.1	4.2	-0.4	0.6	-0.7	2.0	0.7
Financial situation satisfaction	0.5	0.6	2.0	0.4	0.8	-1.4	0.7	0.0
Tinnitus: Yes, now most or all of the time	2.8	3.3	6.9	-2.2	-1.2	-1.8	-0.3	2.6
Commuting to job workplace: Public transport	1.8	2.1	5.0	-0.5	-1.3	-2.2	-1.6	-1.1
Eye problems/disorders: Glaucoma	0.6	0.8	1.6	-1.2	-1.1	0.1	-0.7	0.7
Medication: Blood pressure	0.6	1.2	3.6	0.0	0.7	1.9	1.0	-1.0
Pain type(s) experienced in last month: Hip pain	3.7	4.7	11.1	-3.3	-1.2	-2.4	-0.2	2.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	-0.6	-1.4	0.5	-0.8	-0.2
High cholesterol (Self-reported)	1.2	2.2	3.8	1.9	0.5	1.7	-0.4	-1.9
Medication: Bendroflumethiazide	0.8	1.3	2.8	-0.1	1.3	1.0	1.7	-0.9
Medication: Paracetamol	1.0	1.6	4.9	-2.2	-1.4	-0.5	0.4	0.8
Medication: Lisinopril	1.0	1.3	2.4	0.7	-1.3	1.6	-1.3	-0.7
Medication: Atorvastatin	0.3	0.3	1.0	-0.0	-0.5	1.0	-0.5	-0.2
Illnesses of father: High blood pressure	0.7	0.8	2.8	-1.1	0.1	-1.7	-0.2	-0.1
Alcohol drinker status: Never	0.7	0.9	2.6	0.9	0.4	1.6	0.4	-0.7
Ever smoked	0.6	1.1	1.9	1.2	1.1	-0.9	0.3	-1.4
Basal metabolic rate	0.4	2.0	4.9	-2.2	-0.3	-2.2	0.3	-0.0
Leg fat percentage (left)	0.8	3.0	6.3	-2.5	-1.0	-1.8	-1.1	1.9
Arm fat-free mass (left)	0.3	1.6	3.5	-1.9	0.1	-1.9	0.7	-0.5
Number of operations (self-reported)	0.8	1.2	3.3	0.2	-0.4	-0.1	-1.8	-1.5
Average weekly beer plus cider intake	1.8	2.6	3.9	1.6	2.0	0.3	1.7	-1.9
Irritability	0.8	1.4	3.0	1.1	-0.9	0.4	-1.7	-1.4
Risk taking	0.2	0.3	1.0	0.0	0.6	-0.4	1.0	-0.2
Ever had prostate specific antigen (PSA) test	2.3	2.6	6.7	-0.5	-2.6	1.3	-2.1	0.6
Fractured/broken bones in last 5 years	1.0	1.3	3.1	-1.7	0.6	-1.8	0.4	-0.1
Age started oral contraceptive pill	1.4	1.8	5.2	-0.6	0.3	-2.3	0.2	1.8
Diastolic blood pressure, automated reading	3.0	9.3	18.4	4.1	3.0	1.0	0.9	-4.3
Ever depressed for a whole week	0.6	0.8	2.5	0.1	-0.9	0.2	-1.6	0.7
Unable to work because of sickness or disability	0.2	0.2	0.9	-0.2	0.3	-0.1	-0.2	-0.9
Commuting to job workplace: Cycle	1.2	1.4	3.8	-1.4	-0.4	-2.0	1.1	0.1
Myopia	0.4	0.6	1.2	1.1	-0.7	0.8	-0.9	-0.0
Vascular/heart problems diagnosed by doctor	2.8	7.6	12.0	-2.2	-2.6	-3.5	-2.2	3.1
Cholesterol lowering medication	0.4	0.6	1.1	0.7	-0.5	0.7	-0.9	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.6	-0.2	-0.9	-0.5	-1.6	-0.6
Pain experienced in last month	2.6	4.4	11.1	3.3	0.4	2.6	-0.7	-1.8
Supplements: Calcium	0.5	0.5	1.2	1.1	0.8	-0.0	0.3	-0.9
Basal cell carcinoma (self-reported)	0.5	0.5	1.3	-0.5	-1.1	-0.6	-0.8	0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.5	0.3	-0.0	-0.1	0.3	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.8	0.9	-0.1	-0.8	-0.1	-0.0
Heart disease (siblings)	0.9	1.1	2.9	-1.7	-1.1	-0.4	-0.7	-0.9
Alcohol drinker status: Previous	0.2	0.2	0.9	-0.1	0.0	0.1	-0.2	-1.0
Pack years of smoking	0.3	0.5	1.0	0.3	1.0	-0.2	0.7	-0.8
Impedance of whole body	0.6	3.1	8.6	2.6	0.6	2.9	-0.2	-0.0
Leg fat mass (left)	0.8	3.2	8.4	-2.9	-0.8	-2.2	-0.4	1.4
Arm predicted mass (left)	0.4	1.8	4.6	-2.1	-0.3	-2.0	0.5	-0.4