Hub : Genes

BANK1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0820 0.0360 0.00880 0.006 NA 0.004 NA 0.004 9.3e-02 NA 0.15000 NA 1.4e-01
2 GTEx Adipose Visceral Omentum 0.1940 0.0650 0.00150 0.063 NA 0.070 NA 0.075 3.4e-04 NA 0.00017 NA 9.9e-05
3 GTEx Brain Nucleus accumbens basal ganglia 0.2690 0.0970 0.00300 -0.011 NA -0.011 NA -0.002 9.4e-01 NA 0.94000 NA 3.7e-01
4 METSIM Adipose 0.0436 0.0182 0.00160 0.035 0.011 0.021 0 0.027 4.4e-06 0.0076 0.00035 0.34 5.5e-05
5 TCGA Prostate Adenocarcinoma 0.0448 0.0187 0.00031 0.016 0.023 0.006 NA 0.017 8.0e-03 0.0017 0.06600 NA 6.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.1 0.2 0.4 0.5 0.1 0.5 0.3 -0.6
Bipolar Disorder or Schizophrenia 0.5 1.1 2.2 -1.4 -1.1 0.1 -0.5 1.5
Depressed Affect (Nagel 2018) 1.0 2.1 3.5 -1.9 -1.0 -1.8 -1.7 -0.1
Depression (Nagel 2018) 1.7 2.5 5.5 -2.4 -1.3 -2.0 -1.0 0.4
Intelligence (Savage-Jansen 2018) 0.5 1.6 3.7 1.9 1.4 0.4 0.8 -1.3
Neuroticism (Nagel 2018) 0.4 1.0 2.2 -1.2 -0.2 -1.5 -1.0 0.4
Schizophrenia (2018) 1.3 2.8 5.7 -2.3 -1.5 -0.3 -0.8 2.4
Schizophrenia vs Biploar Disorder 2.3 3.1 7.4 -2.3 -1.5 -0.2 -0.8 2.7
Worry (Nagel 2018) 0.3 0.6 1.1 -1.0 -0.1 -1.0 -0.8 0.5
Alzheimer’s Disease (in mother) 1.4 1.7 3.5 1.9 1.9 0.1 0.9 -0.7
Alzheimer’s Disease (in father) 0.2 0.2 0.6 0.3 0.8 0.2 0.3 0.2
Alzheimer’s Disease (including proxy) 0.4 0.5 1.1 1.0 1.1 0.3 0.3 -0.5
Crohns Disease (2017) 1.2 2.6 8.0 -1.5 -0.6 -0.4 -1.6 2.8
Irritable Bowel Disease (IBD) 1.3 3.1 6.0 -2.4 -0.5 -1.3 -1.3 2.4
Ulcerative Colitis (UC) 1.1 2.1 5.3 -2.3 -0.2 -1.8 -0.4 1.3
Major Depression (MDD) 0.4 0.4 0.9 0.6 0.8 0.4 0.2 -1.0
Reaction Time 0.4 0.8 1.5 1.1 0.6 1.2 0.9 0.1
Verbal and Numeric Reasoning (VNR) 1.0 2.4 6.1 2.5 0.4 1.7 0.0 -1.8
Breast Cancer 0.3 0.8 1.9 -0.5 1.0 -0.2 1.4 -0.7
Ovarian Cancer 1.2 1.6 4.8 0.5 -1.2 0.7 -2.2 -0.8
Prostate Cancer 0.6 0.9 3.2 0.9 0.1 -0.5 -0.5 -1.8
Age at First Birth 0.5 0.7 1.9 -0.7 -1.4 -1.0 -0.2 0.2
Bipolar Disorder (2011) 1.5 1.5 3.3 -1.4 -1.8 -0.2 -1.0 0.9
Body Mass Index (BMI) (2010) 1.6 2.3 4.5 -1.8 -1.7 -0.1 -0.8 2.1
Coronary Artery Disease (CAD) 0.9 1.0 2.5 -1.1 -0.2 0.3 1.6 -1.2
Crohns Disease (2012) 1.1 1.8 5.7 -1.4 0.2 -1.1 -0.4 2.4
Mean Putamen Volume 0.4 0.4 1.7 -0.6 -0.1 1.3 0.2 0.1
Fasting Glucose 0.2 0.2 0.3 -0.5 -0.4 0.6 0.2 0.4
HbA1C 1.4 1.6 3.3 -0.2 -1.1 1.8 -0.5 -1.7
HDL Cholesterol 1.6 2.7 7.1 1.5 -0.1 1.4 -1.5 -2.7
LDL Cholesterol 0.7 1.2 2.6 0.4 1.4 -0.8 1.6 -0.6
Lupus 5.3 8.0 26.7 3.1 1.0 1.6 -0.1 -5.2
Neuroticism (2016) 0.6 0.9 2.8 -1.2 0.2 -1.7 -0.4 -0.2
Primary Biliary Cirrhosis 0.5 0.7 1.3 -1.1 -0.6 1.1 0.3 -0.7
Rheumatoid Arthritis 1.3 1.8 4.0 1.8 0.6 1.3 0.0 -2.0
Schizophrenia (2014) 2.2 4.9 12.8 -3.0 -1.1 -1.2 0.2 3.6
Triglycerides 0.5 0.7 1.6 -1.2 0.0 -0.7 0.5 1.2
Type 2 Diabetes (T2D) (2012) 2.7 3.1 5.6 2.0 1.9 2.4 1.6 -0.2
Ulcerative Colitis 1.2 1.7 3.3 -1.8 0.4 -1.6 0.2 1.7
Blood Eosinophil Count 0.8 5.9 17.5 1.3 1.9 4.2 2.6 -0.2
Blood Platelet Count 0.6 6.4 19.8 -2.1 -0.2 -2.8 0.5 4.5
Blood Red Count 0.3 3.3 11.9 -1.7 0.1 -1.3 0.5 3.5
Blood White Count 0.2 1.8 6.7 -1.4 -0.0 -0.5 0.3 2.6
Heel T-Score 0.2 1.8 3.8 0.9 1.4 1.5 1.9 -0.6
BMI 1.9 10.8 21.8 -4.7 -1.7 -4.0 -1.1 3.5
Height 0.5 10.5 27.7 3.0 2.1 2.8 1.8 -5.3
Waist Hip Ratio (WHR) 1.0 4.7 12.0 3.5 2.2 2.3 0.8 -0.8
Systolic Blood Pressure 3.1 15.6 22.9 4.4 4.3 2.5 3.4 -4.8
Smoking Status 1.2 2.8 6.2 2.2 1.3 0.9 0.1 -2.5
Allergy or Eczema 0.6 1.5 4.1 -1.2 -0.4 -1.2 -0.7 2.0
Cardiovascular Disease 4.4 14.4 24.9 3.6 3.3 5.0 3.1 -3.7
Hypothyroidism (self reported) 3.8 8.7 17.3 3.6 1.8 4.2 0.5 -3.1
Respiratory disease 0.3 0.6 2.2 -0.1 -0.3 -0.8 -0.5 -1.5
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.4 -0.3 -1.2 1.1 -0.7 1.0
Lung FEV1/FVC ratio 0.5 2.8 8.4 0.0 -1.2 1.9 -2.9 -0.7
Lung FVC 0.8 3.9 8.4 -1.8 -0.4 -2.9 -0.6 2.7
Neuroticism 0.3 0.7 2.6 -0.4 0.4 -1.6 -0.7 0.4
Chronotype (morning person) 0.4 0.9 1.9 0.2 -1.2 -0.7 -0.8 -1.4
Hair Pigment 0.1 1.6 2.5 1.6 1.4 -0.8 1.6 0.8
Tanning 0.0 0.5 1.5 -0.6 0.4 0.5 1.2 0.6
Hand grip strength (left) 4.1 10.9 25.8 5.1 1.7 2.2 -0.2 -4.6
Number of treatments/medications taken 0.4 0.8 2.1 0.0 0.4 1.5 1.3 -0.3
Average weekly spirits intake 0.3 0.3 0.7 -0.4 0.1 0.8 -0.2 -0.8
Sensitivity / hurt feelings 2.0 3.4 9.7 -1.2 0.8 -2.2 0.5 3.1
Frequency of depressed mood in last 2 weeks 1.3 1.8 4.0 -2.0 -1.1 -1.6 -0.6 0.8
Hearing difficulty/problems: Yes 0.4 0.6 1.2 -0.9 -0.7 0.4 -0.4 1.1
Relative age of first facial hair 1.5 3.1 7.0 2.3 2.6 -0.8 1.3 1.1
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.8 -1.7 -0.1 0.6 0.6 -0.6
Ever used hormone-replacement therapy (HRT) 2.4 3.0 7.3 -1.1 -2.3 0.9 -2.7 -0.9
Ever had hysterectomy (womb removed) 1.1 1.2 3.1 -1.7 -0.6 -0.1 -0.4 1.6
Systolic blood pressure, automated reading 1.3 3.9 8.6 2.6 1.8 0.9 0.2 -2.9
Eye problems/disorders: Diabetes related eye disease 1.1 1.3 3.2 -1.8 -0.3 -1.1 0.3 1.3
Angina 1.1 1.5 6.3 0.2 0.2 0.6 0.8 -2.5
Medication for hormone replacement therapy 0.4 0.5 0.9 -0.5 1.0 0.0 0.6 -0.9
Vitamin and mineral supplements 0.4 0.5 2.3 0.4 0.3 0.1 -0.2 -1.5
Supplements: Zinc 0.3 0.3 1.0 -1.0 -0.3 -0.6 -0.1 -0.2
Medication: Co-codamol 1.5 1.7 2.6 1.1 1.6 0.8 1.6 -1.2
Medication: Metformin 0.2 0.3 0.7 -0.4 0.4 -0.2 0.8 0.6
Diabetes (father) 0.4 0.5 1.0 0.6 0.8 0.1 -1.0 -0.8
Diabetes (mother) 0.4 0.6 1.1 -0.4 -0.6 1.1 -0.5 0.9
Severe depression (siblings) 0.6 0.6 2.2 -0.3 -0.7 0.4 -1.5 0.6
Pack years adult smoking proportion 0.6 1.0 2.6 0.6 1.6 -0.4 1.2 -0.5
Impedance of leg (right) 1.5 7.2 17.3 3.8 0.8 4.2 0.1 -1.8
Leg fat-free mass (left) 0.7 3.9 9.3 -3.0 -0.7 -3.0 0.2 1.0
Trunk fat percentage 1.9 7.5 16.5 -4.1 -1.5 -2.8 -0.9 3.2
Hand grip strength (right) 2.8 7.7 17.9 4.2 0.6 2.6 -0.5 -3.7
Townsend deprivation index at recruitment 0.1 0.2 0.8 -0.9 0.0 -0.0 -0.1 -0.3
Current tobacco smoking 1.0 1.6 3.8 1.5 2.0 0.3 1.1 -0.5
Average weekly fortified wine intake 0.4 0.5 0.9 0.3 0.5 -0.8 1.0 0.6
Maternal smoking around birth 0.7 1.0 2.3 0.6 0.9 -1.1 -0.5 -1.5
Fed-up feelings 0.4 0.8 2.2 -0.9 -0.2 -1.5 -0.9 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.3 -0.7 -0.4 -0.3 -1.0 -1.1
Relative age voice broke 0.3 0.4 1.7 -0.3 0.3 -0.3 0.3 1.3
Taking other prescription medications 0.5 0.8 2.5 -1.6 0.3 0.3 1.2 -0.2
Age when periods started (menarche) 4.0 9.7 21.4 -2.7 0.7 -3.3 2.9 4.6
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 0.2 0.4 -0.2 -0.5 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.3 0.9 0.6 0.1 1.2 0.6
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 6.6 -1.2 -0.5 -2.6 0.2 0.8
Qualifications: CSEs or equivalent 0.7 0.9 2.0 -1.1 -1.4 -0.4 -0.7 0.7
Serious illness, injury or assault to yourself 1.9 2.3 3.5 -1.3 -1.9 1.8 -1.4 1.1
High blood pressure 2.8 7.8 12.2 2.2 2.9 3.5 2.2 -2.9
Hayfever, allergic rhinitis or eczema 0.7 1.5 3.0 -1.1 -0.4 -1.6 -0.9 1.7
Multivitamins +/- minerals 0.1 0.2 0.7 -0.0 0.2 -0.3 0.3 0.8
Stomach or abdominal pain in last month 0.7 0.9 2.1 -1.5 -0.4 0.6 0.1 1.2
Supplements: Glucosamine 1.4 1.9 6.0 -2.5 -0.5 -0.4 0.7 1.6
Diverticular disease/diverticulitis (self-reported) 1.2 1.5 4.5 0.3 -0.5 0.4 -1.5 -2.1
Medication: Atenolol 1.1 1.4 3.7 1.0 0.2 1.4 0.8 -1.9
Medication: Levothyroxine sodium 1.4 2.4 5.9 1.5 0.5 2.4 0.5 -1.9
Sitting height 0.4 3.0 7.9 -2.8 -1.2 -1.9 -0.1 1.3
Chronic bronchitis/emphysema (father) 0.5 0.6 2.1 -0.5 -0.5 -0.1 0.4 1.5
High blood pressure (mother) 1.1 1.5 3.2 1.8 1.0 1.1 -0.2 -1.5
Body mass index (BMI) 1.8 7.5 18.2 -4.3 -1.6 -3.3 -0.8 2.3
Impedance of leg (left) 1.7 8.0 18.1 4.1 1.3 4.3 0.3 -1.8
Leg predicted mass (left) 0.8 4.0 9.5 -3.1 -0.6 -3.0 0.3 1.0
Trunk fat mass 1.4 6.1 14.2 -3.8 -1.2 -2.9 -0.6 2.5
Waist circumference 0.7 2.4 6.2 -2.5 -0.4 -1.9 -0.2 1.5
Number of incorrect matches in round 0.4 0.6 1.2 -1.0 0.6 -0.3 0.6 -1.1
Past tobacco smoking 0.5 1.0 2.8 0.1 -0.0 1.7 0.2 1.4
Alcohol usually taken with meals 0.3 0.5 0.9 0.7 -0.5 0.6 -0.6 0.9
Nervous feelings 0.2 0.3 1.0 -1.0 0.6 -0.2 0.0 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.2 0.5 -0.7 0.2 -0.4 0.1 0.6
Hearing difficulty/problems with background noise 0.5 0.8 1.8 -1.4 0.1 -0.7 0.3 1.3
Hair/balding pattern: Pattern 2 1.0 1.3 2.3 -0.8 -1.5 1.5 -1.1 -0.3
Had menopause 1.1 1.3 3.1 -1.1 -1.8 -0.0 -1.5 0.4
Had other major operations 0.7 0.9 2.7 1.0 0.3 -0.3 -0.7 -1.6
Forced vital capacity (FVC) 0.1 0.5 1.8 -0.0 -0.3 -1.4 -0.4 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 3.7 1.4 1.5 -0.3 1.9 0.0
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.2 -0.6 -0.7 -0.1 -1.5 1.0
Qualifications: None of the above 1.0 2.2 7.0 -1.7 -0.5 -0.8 -0.6 -2.6
Financial difficulties in last 2 years 1.2 1.6 4.8 -0.9 0.5 -2.2 -0.3 1.5
Mouth/teeth dental problems 0.9 1.4 3.2 1.0 1.2 -0.7 0.9 1.8
Heart attack 0.2 0.3 1.1 0.3 0.1 -0.3 0.4 -1.1
Allergy 0.8 1.9 5.1 1.1 -0.1 2.3 -0.0 -1.7
Pain all over the body in last month 1.4 1.6 4.0 -1.2 1.0 -1.1 2.0 0.1
Diabetes (self-reported) 0.2 0.4 0.7 -0.8 -0.4 0.6 0.4 0.6
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.1 1.5 1.0 0.4 -0.6 -0.9
Medication: Ramipril 3.5 4.5 8.9 2.4 2.0 3.0 1.9 0.6
Medication: Simvastatin 0.6 0.9 2.6 1.6 0.3 1.2 0.0 -0.8
Fluid intelligence score 1.2 2.6 6.2 1.8 0.1 1.8 -0.1 -2.5
Illnesses of siblings 0.3 0.5 1.3 1.1 0.0 -0.1 0.2 1.0
Neuroticism score 0.4 0.9 2.5 -0.7 -0.3 -1.6 -1.1 0.1
Weight 0.8 4.1 11.8 -3.4 -0.9 -2.5 -0.2 1.1
Impedance of arm (right) 0.3 1.2 2.2 1.5 0.3 1.5 -0.4 1.2
Arm fat percentage (right) 2.1 8.2 17.7 -4.2 -1.6 -3.3 -1.1 2.9
Trunk fat-free mass 0.1 0.8 1.8 -0.9 0.0 -1.2 0.4 -1.3
Hip circumference 1.8 7.7 18.3 -4.3 -2.0 -3.0 -0.9 2.5
Time employed in main current job 0.4 0.5 1.4 -1.2 0.6 -0.2 0.8 -0.3
Alcohol intake versus 10 years previously 0.2 0.4 1.0 -1.0 -0.6 0.5 -0.2 0.4
Father’s age at death 0.4 0.5 2.0 0.6 -0.1 1.4 -0.6 0.1
Worrier / anxious feelings 1.2 2.2 7.7 -1.0 -0.7 -2.8 -1.0 0.9
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.2 8.3 -2.6 -0.0 -2.9 0.2 1.0
Falls in the last year 0.7 1.0 2.7 -1.6 -0.1 1.3 0.3 0.5
Hair/balding pattern: Pattern 3 1.2 1.7 5.1 0.9 2.3 0.6 1.5 -0.4
Number of live births 1.0 1.4 4.7 -0.9 0.8 -0.6 2.2 -0.5
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.7 -0.4 -0.6 -0.8 -0.7 0.5
Pulse rate 0.8 1.4 2.8 -1.1 0.9 -1.7 1.2 0.8
Happiness 2.1 2.5 5.6 -0.1 2.4 -2.2 1.5 0.2
Noisy workplace 0.4 0.5 1.6 -0.9 -1.2 0.0 0.2 0.2
Qualifications: A levels/AS levels or equivalent 0.5 1.0 2.5 -0.8 -1.3 -0.1 -1.6 -0.5
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.1 3.9 -1.8 -2.0 0.1 -1.3 1.3
Mouth/teeth dental problems: Dentures 0.3 0.6 1.4 0.8 -0.1 0.4 -0.8 -1.2
Asthma 0.6 1.2 5.5 -0.7 0.4 -2.3 0.2 0.0
Medication: Ibuprofen (e.g. Nurofen) 1.5 2.0 4.3 -2.1 -2.1 0.3 -0.9 0.6
Medication: Cholesterol lowering 0.6 1.0 2.2 1.5 -0.0 0.8 -0.3 -1.4
Depression (self-reported) 0.5 0.6 1.6 0.0 0.2 1.3 -0.4 -1.0
Medication: Lansoprazole 0.8 0.9 1.6 -1.3 -1.3 0.2 -1.1 -0.2
Prospective memory result 3.3 4.1 9.4 -2.5 -0.1 -3.1 0.8 2.1
Lung cancer (father) 0.5 0.6 1.7 -0.9 0.4 -1.3 0.1 0.2
Illnesses of mother 0.5 0.6 2.4 -0.2 0.2 -1.5 -0.2 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.0 -0.4 0.1 -1.0 -0.3 1.0
Pulse wave Arterial Stiffness index 1.5 1.8 3.2 -1.2 1.2 -0.4 1.6 1.8
Impedance of arm (left) 0.3 1.4 2.9 1.7 0.2 1.7 -0.6 0.8
Arm fat mass (right) 1.7 6.9 16.3 -4.0 -1.5 -3.2 -0.8 2.3
Trunk predicted mass 0.1 0.8 1.8 -0.9 -0.0 -1.2 0.3 -1.3
Standing height 0.2 1.8 4.2 1.2 1.0 1.2 1.0 -2.0
Length of working week for main job 0.6 0.6 2.1 1.5 0.3 0.9 -0.2 -0.2
Exposure to tobacco smoke at home 0.6 0.7 2.4 -0.1 -0.3 1.6 -0.9 0.3
Breastfed as a baby 0.9 1.1 3.2 0.1 -1.4 0.6 -0.1 1.8
Tense / ‘highly strung’ 0.6 1.0 2.9 0.0 0.7 -1.7 -0.5 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.3 -0.4 -0.6 0.1 -1.1 -1.1
Hair/balding pattern: Pattern 4 0.2 0.6 1.3 0.4 1.0 -0.3 1.2 0.5
Birth weight of first child 0.3 0.5 0.9 -0.2 0.6 -0.7 1.0 0.7
Peak expiratory flow (PEF) 0.4 0.8 2.0 -0.6 -1.4 -0.2 -1.3 -0.1
Pulse wave reflection index 0.5 0.7 2.5 0.6 0.5 1.6 0.3 0.3
Ever highly irritable/argumentative for 2 days 0.6 0.7 3.1 -0.0 0.4 -1.8 -0.1 0.7
Loud music exposure frequency 0.4 0.5 1.6 1.3 -0.0 0.9 -0.2 -0.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.6 0.3 -0.5 0.1 0.3 1.6
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 3.9 -2.0 -1.3 -1.3 -0.8 -0.5
Blood clot in the leg (DVT) 0.2 0.3 1.0 0.4 -0.2 -1.0 0.2 0.2
Medication: Paracetamol 0.9 1.5 4.6 -2.1 -1.5 0.0 0.1 0.8
Headache pain in last month 0.3 0.5 1.3 -0.4 -0.2 -1.2 -0.8 0.4
Medication for cholesterol, blood pressure or diabetes 1.5 2.4 4.8 -1.6 -1.3 -2.2 -1.4 0.9
Glaucoma (self-reported) 0.4 0.5 0.9 -0.9 -0.1 -0.9 0.3 0.8
Gout (self-reported) 1.2 1.6 3.8 1.9 1.0 0.8 0.4 -1.6
Hypothyroidism/myxoedema (self-reported) 2.0 3.9 9.1 2.2 1.0 3.0 0.6 -2.1
Medication: Amlodipine 1.0 1.5 5.8 0.8 0.7 2.4 0.5 -0.4
Medication: Ventolin 100micrograms inhaler 1.5 1.9 5.1 -2.3 0.1 -1.3 1.5 0.8
Birth weight 0.1 0.2 0.3 -0.1 0.4 -0.5 0.5 0.5
Chronic bronchitis/emphysema (mother) 1.1 1.3 2.8 0.8 1.2 1.2 1.7 -0.5
High blood pressure (siblings) 0.4 0.5 1.6 -0.9 -0.1 -0.2 -0.1 -1.3
Forced vital capacity (FVC), Best measure 0.2 0.6 1.6 -0.2 0.2 -1.3 0.3 1.0
Body fat percentage 1.6 6.2 13.8 -3.7 -1.5 -2.5 -1.0 2.8
Leg fat percentage (right) 0.8 3.0 6.6 -2.6 -1.2 -1.7 -1.1 1.8
Arm fat-free mass (right) 0.3 1.4 3.7 -1.9 -0.4 -1.6 0.4 -0.7
Exposure to tobacco smoke outside home 0.5 0.6 2.4 -1.5 0.3 -0.7 0.3 0.0
Comparative body size at age 10 1.0 2.8 5.5 -1.1 -1.8 -1.6 -2.4 1.3
Number of full brothers 0.2 0.3 1.0 -1.0 -0.5 -0.3 0.0 0.3
Worry too long after embarrassment 0.7 1.2 3.0 0.4 0.8 -1.7 0.5 1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 7.7 0.9 -0.1 1.0 -0.8 -2.8
Wheeze or whistling in the chest in last year 1.0 1.8 3.9 -2.0 0.1 -1.3 1.3 1.3
Number of children fathered 1.0 1.2 4.8 0.9 0.1 2.2 -0.0 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.5 0.6 -0.3 0.8 -1.6 -1.9
Age at first live birth 0.6 1.1 3.2 -0.1 0.0 -1.8 0.5 1.4
Pulse wave peak to peak time 1.6 1.9 3.9 1.4 -1.1 0.5 -1.5 -2.0
Health satisfaction 3.1 4.0 7.4 -2.4 0.6 -2.7 1.8 1.7
Shortness of breath walking on level ground 1.2 1.5 3.4 -1.3 0.5 -1.9 1.3 -0.5
Qualifications: College or University degree 0.3 1.0 2.8 1.2 0.3 1.7 -0.7 -0.0
Eye problems/disorders: None of the above 1.5 1.7 5.2 0.7 -0.8 2.3 0.1 -1.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 1.0 -0.0 -0.1 -1.0 -0.4 -0.2
Emphysema/chronic bronchitis 1.5 1.6 4.1 1.8 0.3 -0.5 -0.7 -2.0
Medication for pain relief, constipation, heartburn 1.4 2.4 4.6 2.1 2.2 0.2 0.4 -1.5
Neck or shoulder pain in last month 1.0 1.4 5.0 -2.2 -0.7 -1.0 -0.4 0.6
Medication: Blood pressure 2.0 3.5 6.2 1.0 2.3 2.2 2.5 -0.3
Angina (self-reported) 1.0 1.3 4.9 0.2 0.4 0.5 1.1 -2.2
Migraine (self-reported) 1.3 1.6 4.1 1.0 2.0 -1.5 0.9 0.3
Medication: Ibuprofen 1.3 1.6 4.1 -1.6 -2.0 0.8 -0.7 0.2
Medication: Allopurinol 2.4 3.1 5.4 2.3 1.2 1.9 0.4 -2.3
Medication: Omeprazole 0.9 1.1 2.3 -0.2 -1.2 -0.9 -1.5 -0.7
Medication: Seretide 50 evohaler 0.4 0.5 1.3 -1.1 -0.5 -0.2 0.5 0.7
Mean time to correctly identify matches 0.3 0.5 1.0 0.6 0.6 0.1 1.0 0.9
Heart disease (mother) 0.9 1.1 4.1 -2.0 -0.9 -0.0 0.2 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 2.8 1.7 1.1 -0.0 0.8 -0.3
Whole body fat mass 1.4 5.7 13.2 -3.6 -1.2 -2.8 -0.6 2.3
Leg fat mass (right) 0.9 3.3 8.9 -3.0 -0.9 -2.2 -0.5 1.3
Arm predicted mass (right) 0.3 1.3 3.8 -2.0 -0.3 -1.4 0.4 -0.6
Pulse rate, automated reading 0.1 0.2 0.8 -0.5 -0.2 -0.1 -0.9 -0.1
Alcohol intake frequency. 0.4 0.8 1.9 -1.1 -0.8 -0.7 -0.0 1.4
Comparative height size at age 10 1.0 5.7 15.5 2.2 -0.3 2.8 -0.4 -3.9
Number of full sisters 1.3 1.6 4.6 -2.1 -1.6 0.1 -0.4 0.6
Suffer from ‘nerves’ 0.3 0.5 1.1 -1.1 0.4 -1.0 -0.2 0.7
Overall health rating 1.0 2.2 7.1 -2.7 -1.2 -1.6 -0.1 -0.4
Chest pain or discomfort 0.9 1.3 3.0 0.3 1.7 -1.2 1.4 -0.1
Had major operations 0.6 0.8 3.6 -0.0 -0.4 -0.2 -0.2 -1.9
Age at last live birth 0.9 1.3 2.4 -1.5 0.2 -1.4 0.9 1.1
Family relationship satisfaction 1.6 1.9 5.2 1.0 1.7 -2.3 0.8 -0.1
Leg pain on walking 3.1 3.9 10.9 -2.6 -0.3 -3.3 1.1 0.9
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.6 11.1 -1.1 -0.4 -0.4 0.7 3.3
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.7 0.7 1.0 0.3 1.2 1.6
Illness, injury, bereavement, stress in last 2 years 2.4 3.0 6.7 2.6 2.2 0.7 0.9 -1.3
Medication: Aspirin 0.4 0.5 1.2 -0.2 0.3 -1.0 1.1 -0.4
Supplements: Vitamin C 0.2 0.2 0.4 -0.5 0.3 -0.4 0.4 0.6
Knee pain experienced in last month 1.7 2.6 6.5 -2.6 1.0 -1.4 1.0 1.5
Hypertension (Self-reported) 3.3 9.2 13.9 2.5 3.1 3.7 2.2 -3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.8 0.3 -0.2 -0.6 -0.9 -0.4
Illnesses of father: Heart disease 1.6 2.2 5.0 -2.2 -0.3 -0.6 0.8 2.2
Illnesses of siblings: Diabetes 1.1 1.3 4.6 -2.2 -1.3 0.4 0.3 0.4
Smoking status: Previous 0.5 0.7 2.8 -0.2 0.1 -1.7 -0.0 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.0 1.4 0.9 0.1 1.1 -1.1
Whole body fat-free mass 0.3 1.7 4.5 -1.9 -0.1 -2.1 0.5 -0.3
Leg fat-free mass (right) 0.7 3.7 8.9 -3.0 -0.5 -2.9 0.4 0.9
Arm fat percentage (left) 1.9 7.7 16.7 -4.1 -1.8 -3.0 -1.4 2.7
Average weekly red wine intake 2.3 3.4 6.4 1.6 2.5 0.1 2.4 1.4
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.0 -0.8 -1.4 -0.1 -0.8 0.4
Mood swings 0.6 1.1 2.0 -1.0 -0.5 -1.1 -1.1 -1.4
Loneliness, isolation 1.5 2.1 5.0 -2.2 -1.9 0.9 -1.0 0.1
Long-standing illness, disability or infirmity 1.4 2.2 9.1 -3.0 -0.6 -0.5 0.3 1.1
Ever had bowel cancer screening 1.1 1.3 3.0 0.1 -1.1 1.7 -1.0 -1.2
Diabetes diagnosed by doctor 0.4 0.7 1.6 -1.2 -0.9 0.2 0.2 1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 1.9 -1.1 -1.2 1.4 -0.7 -0.8
Friendships satisfaction 1.4 1.7 4.3 0.2 1.4 -2.1 0.5 1.4
Qualifications: nursing, teaching 0.1 0.1 0.2 0.5 0.5 -0.2 -0.0 -0.3
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.4 -0.5 0.2 -0.2 -0.2
Eye problems/disorders: Cataract 1.0 1.2 4.0 0.1 0.3 -1.2 -0.6 2.0
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 3.8 0.6 -0.6 1.9 -0.9 -1.3
Medication for cholesterol 1.6 2.4 4.4 -0.9 -1.4 -2.1 -0.9 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.3 3.8 8.3 -1.5 -2.7 0.4 -2.9 -1.1
Back pain experienced in last month 2.0 2.9 8.4 -2.9 -1.9 -1.4 -0.5 0.7
Mineral and other dietary supplements 0.2 0.3 0.6 0.6 0.8 -0.8 0.1 -0.2
Breast cancer (self-reported) 0.5 0.6 1.4 1.2 0.9 0.5 0.2 -0.8
Asthma (self-reported) 0.5 1.0 4.5 -0.7 0.3 -2.1 0.2 -0.1
Osteoporosis (self-reported) 0.2 0.3 1.0 -1.0 -0.1 0.3 -0.0 -0.6
Osteoarthritis (self-reported) 1.7 2.3 5.3 -2.3 -0.9 -0.6 -0.1 2.2
Medication: Aspirin 0.5 0.6 1.4 -0.7 -0.1 -1.2 1.0 -0.4
Medication: Gliclazide 0.5 0.5 1.2 -0.4 0.6 -0.6 1.1 0.7
Illnesses of father: None of the above (group 1) 1.0 1.2 4.5 2.1 1.1 0.2 -0.1 -0.6
Smoking status: Current 0.7 1.1 2.5 1.4 1.6 0.2 0.8 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 5.4 -2.1 -1.9 -1.1 -1.1 2.3
Whole body water mass 0.3 1.7 4.5 -2.0 -0.3 -2.1 0.4 -0.4
Leg predicted mass (right) 0.7 3.8 9.2 -3.0 -0.5 -3.0 0.3 0.8
Arm fat mass (left) 1.5 6.0 13.8 -3.7 -1.3 -3.2 -0.8 1.9
Number of self-reported non-cancer illnesses 0.8 1.3 3.3 0.4 1.0 1.8 0.7 -1.2
Average weekly champagne plus white wine intake 1.6 2.3 4.1 0.1 -2.0 1.4 -1.6 -1.6
Miserableness 0.2 0.4 1.1 -0.0 1.1 -0.8 -0.5 0.0
Guilty feelings 0.4 0.6 2.0 0.8 0.4 0.2 -0.3 -1.4
Wears glasses or contact lenses 4.0 4.6 13.3 -3.6 -1.0 -1.0 -0.1 2.8
Ever taken oral contraceptive pill 2.8 3.1 5.2 0.8 -2.3 1.5 -2.2 -1.6
Hearing aid user 2.2 2.4 4.3 0.4 -1.4 1.9 -2.1 -1.5
Mother’s age at death 0.9 1.1 4.2 -0.4 0.6 -0.7 2.0 0.7
Financial situation satisfaction 0.5 0.6 2.0 0.4 0.8 -1.4 0.7 0.0
Tinnitus: Yes, now most or all of the time 2.8 3.3 6.9 -2.2 -1.2 -1.8 -0.3 2.6
Commuting to job workplace: Public transport 1.8 2.1 5.0 -0.5 -1.3 -2.2 -1.6 -1.1
Eye problems/disorders: Glaucoma 0.6 0.8 1.6 -1.2 -1.1 0.1 -0.7 0.7
Medication: Blood pressure 0.6 1.2 3.6 0.0 0.7 1.9 1.0 -1.0
Pain type(s) experienced in last month: Hip pain 3.7 4.7 11.1 -3.3 -1.2 -2.4 -0.2 2.2
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.1 -0.6 -1.4 0.5 -0.8 -0.2
High cholesterol (Self-reported) 1.2 2.2 3.8 1.9 0.5 1.7 -0.4 -1.9
Medication: Bendroflumethiazide 0.8 1.3 2.8 -0.1 1.3 1.0 1.7 -0.9
Medication: Paracetamol 1.0 1.6 4.9 -2.2 -1.4 -0.5 0.4 0.8
Medication: Lisinopril 1.0 1.3 2.4 0.7 -1.3 1.6 -1.3 -0.7
Medication: Atorvastatin 0.3 0.3 1.0 -0.0 -0.5 1.0 -0.5 -0.2
Illnesses of father: High blood pressure 0.7 0.8 2.8 -1.1 0.1 -1.7 -0.2 -0.1
Alcohol drinker status: Never 0.7 0.9 2.6 0.9 0.4 1.6 0.4 -0.7
Ever smoked 0.6 1.1 1.9 1.2 1.1 -0.9 0.3 -1.4
Basal metabolic rate 0.4 2.0 4.9 -2.2 -0.3 -2.2 0.3 -0.0
Leg fat percentage (left) 0.8 3.0 6.3 -2.5 -1.0 -1.8 -1.1 1.9
Arm fat-free mass (left) 0.3 1.6 3.5 -1.9 0.1 -1.9 0.7 -0.5
Number of operations (self-reported) 0.8 1.2 3.3 0.2 -0.4 -0.1 -1.8 -1.5
Average weekly beer plus cider intake 1.8 2.6 3.9 1.6 2.0 0.3 1.7 -1.9
Irritability 0.8 1.4 3.0 1.1 -0.9 0.4 -1.7 -1.4
Risk taking 0.2 0.3 1.0 0.0 0.6 -0.4 1.0 -0.2
Ever had prostate specific antigen (PSA) test 2.3 2.6 6.7 -0.5 -2.6 1.3 -2.1 0.6
Fractured/broken bones in last 5 years 1.0 1.3 3.1 -1.7 0.6 -1.8 0.4 -0.1
Age started oral contraceptive pill 1.4 1.8 5.2 -0.6 0.3 -2.3 0.2 1.8
Diastolic blood pressure, automated reading 3.0 9.3 18.4 4.1 3.0 1.0 0.9 -4.3
Ever depressed for a whole week 0.6 0.8 2.5 0.1 -0.9 0.2 -1.6 0.7
Unable to work because of sickness or disability 0.2 0.2 0.9 -0.2 0.3 -0.1 -0.2 -0.9
Commuting to job workplace: Cycle 1.2 1.4 3.8 -1.4 -0.4 -2.0 1.1 0.1
Myopia 0.4 0.6 1.2 1.1 -0.7 0.8 -0.9 -0.0
Vascular/heart problems diagnosed by doctor 2.8 7.6 12.0 -2.2 -2.6 -3.5 -2.2 3.1
Cholesterol lowering medication 0.4 0.6 1.1 0.7 -0.5 0.7 -0.9 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.6 -0.2 -0.9 -0.5 -1.6 -0.6
Pain experienced in last month 2.6 4.4 11.1 3.3 0.4 2.6 -0.7 -1.8
Supplements: Calcium 0.5 0.5 1.2 1.1 0.8 -0.0 0.3 -0.9
Basal cell carcinoma (self-reported) 0.5 0.5 1.3 -0.5 -1.1 -0.6 -0.8 0.5
Heart attack/myocardial infarction (self-reported) 0.3 0.3 1.5 0.3 -0.0 -0.1 0.3 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.8 0.9 -0.1 -0.8 -0.1 -0.0
Heart disease (siblings) 0.9 1.1 2.9 -1.7 -1.1 -0.4 -0.7 -0.9
Alcohol drinker status: Previous 0.2 0.2 0.9 -0.1 0.0 0.1 -0.2 -1.0
Pack years of smoking 0.3 0.5 1.0 0.3 1.0 -0.2 0.7 -0.8
Impedance of whole body 0.6 3.1 8.6 2.6 0.6 2.9 -0.2 -0.0
Leg fat mass (left) 0.8 3.2 8.4 -2.9 -0.8 -2.2 -0.4 1.4
Arm predicted mass (left) 0.4 1.8 4.6 -2.1 -0.3 -2.0 0.5 -0.4