Hub : Genes

BAP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0360	0.0170	0.00022	0.018	0.033	0.014	0.032	0.018	0.00250	5.5e-05	0.00600	7.5e-05	0.00270
2	GTEx	Testis	0.1570	0.0840	0.00250	0.052	NA	0.039	NA	0.059	0.00240	NA	0.00770	NA	0.00130
3	TCGA	Breast Invasive Carcinoma	0.0162	0.0090	0.00019	0.016	0.020	0.015	NA	0.016	0.00021	5.1e-05	0.00033	NA	0.00023
4	TCGA	Esophageal Carcinoma	0.1440	0.0910	0.00790	-0.006	0.015	0.005	NA	0.006	0.57000	1.0e-01	0.22000	NA	0.19000
5	TCGA	Prostate Adenocarcinoma	0.0319	0.0204	0.00160	0.036	0.026	0.009	NA	0.032	0.00011	9.4e-04	0.03600	NA	0.00024

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.4	2.1	-0.5	1.2	-1.1	-1.4	-1.4
Bipolar Disorder or Schizophrenia	0.8	2.0	2.6	-0.7	1.6	-1.4	-1.6	-1.6
Depressed Affect (Nagel 2018)	1.0	2.1	3.2	-1.8	-1.1	1.7	0.9	1.6
Depression (Nagel 2018)	1.0	1.5	2.9	-0.1	1.0	-1.3	-1.7	-1.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.4	2.1	0.3	0.0	0.6	-0.0
Neuroticism (Nagel 2018)	0.4	0.8	2.4	-1.5	-0.5	0.8	-0.3	0.9
Schizophrenia (2018)	0.4	0.7	1.1	-0.4	1.1	-1.0	-0.8	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	0.0	-0.7	0.5	0.9	1.0
Worry (Nagel 2018)	0.6	1.3	3.5	-0.6	0.9	-0.9	-1.9	-1.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-0.9	-0.5	0.7	0.6	1.0
Alzheimer’s Disease (in father)	1.3	1.4	2.8	-1.7	-1.1	0.8	1.1	0.8
Alzheimer’s Disease (including proxy)	1.9	2.7	4.3	-2.1	-1.4	1.5	1.6	1.6
Crohns Disease (2017)	0.4	0.8	1.2	-0.8	-1.1	1.0	0.9	0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.6	-0.1	0.7	0.3	0.4
Ulcerative Colitis (UC)	0.1	0.1	0.4	-0.2	0.7	0.2	-0.0	0.1
Major Depression (MDD)	0.3	0.4	1.5	-1.2	-0.3	-0.2	0.0	-0.6
Reaction Time	0.4	0.8	1.0	-1.0	-1.0	0.7	0.9	0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.0	0.8	-0.6	1.2	1.4	1.3
Breast Cancer	0.1	0.2	1.0	0.1	-0.2	0.4	0.2	1.0
Ovarian Cancer	1.9	2.6	3.5	1.0	1.6	-1.7	-1.7	-1.9
Prostate Cancer	0.1	0.1	0.2	-0.5	-0.2	0.1	-0.2	0.4
Age at First Birth	0.1	0.1	0.3	0.1	-0.1	-0.4	0.6	-0.3
Bipolar Disorder (2011)	1.5	1.4	6.2	-2.5	-0.5	0.7	0.3	0.4
Body Mass Index (BMI) (2010)	0.2	0.3	1.2	0.3	-0.1	0.5	-0.1	1.1
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.8	0.3	-0.3	-0.2	0.2
Crohns Disease (2012)	0.2	0.3	0.7	-0.5	-0.8	0.5	0.3	0.4
Mean Putamen Volume	0.1	0.2	0.3	-0.4	-0.2	-0.4	-0.2	-0.6
Fasting Glucose	0.6	0.8	1.7	1.3	1.2	-0.4	-0.7	-0.2
HbA1C	0.4	0.5	0.8	-0.5	-0.7	0.8	0.9	0.4
HDL Cholesterol	9.7	16.2	17.4	-3.9	-4.2	4.0	4.1	4.0
LDL Cholesterol	3.1	4.9	9.9	3.1	1.8	-2.2	-1.8	-1.8
Lupus	0.0	0.0	0.0	0.1	0.1	0.2	0.2	0.1
Neuroticism (2016)	0.2	0.2	0.6	-0.8	0.2	0.6	-0.1	-0.1
Primary Biliary Cirrhosis	0.5	0.7	1.3	1.0	0.7	-0.7	-0.2	-1.1
Rheumatoid Arthritis	0.2	0.3	0.8	-0.2	-0.8	0.0	0.9	-0.4
Schizophrenia (2014)	1.0	2.2	3.7	-0.0	1.9	-1.5	-1.6	-1.5
Triglycerides	4.6	7.5	10.6	2.8	3.2	-2.2	-2.9	-2.3
Type 2 Diabetes (T2D) (2012)	3.4	3.9	4.6	1.3	2.2	-2.1	-2.1	-2.0
Ulcerative Colitis	0.3	0.4	0.8	-0.8	-0.3	0.6	0.2	0.9
Blood Eosinophil Count	0.7	5.1	7.3	2.4	2.5	-2.2	-1.3	-2.7
Blood Platelet Count	0.2	1.9	5.1	2.3	-0.8	0.4	1.7	0.9
Blood Red Count	0.7	6.8	10.0	0.1	2.7	-2.6	-3.1	-3.2
Blood White Count	2.1	15.6	16.0	4.0	3.9	-4.0	-4.0	-3.9
Heel T-Score	0.2	1.6	3.2	1.8	0.8	-1.4	-0.8	-1.2
BMI	0.6	3.5	7.2	0.6	-0.3	2.7	1.7	2.6
Height	1.6	30.5	79.4	-8.9	-4.6	5.0	3.1	4.2
Waist Hip Ratio (WHR)	15.5	69.8	85.2	4.8	8.9	-8.8	-9.2	-9.2
Systolic Blood Pressure	0.3	1.7	5.6	2.4	1.0	-1.0	-0.4	-0.8
Smoking Status	1.0	2.5	8.2	2.9	1.4	-1.0	-0.9	-0.4
Allergy or Eczema	0.2	0.5	1.4	-1.2	-0.5	0.6	0.8	0.2
Cardiovascular Disease	0.2	0.8	2.6	1.6	1.0	-0.2	-0.4	-0.3
Hypothyroidism (self reported)	1.3	2.9	4.1	-1.0	-2.0	1.6	2.0	1.7
Respiratory disease	0.5	1.0	2.4	-1.5	-0.5	1.0	1.0	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.4	1.2	0.4	-0.1	-0.0	0.1
Lung FEV1/FVC ratio	0.1	0.3	1.2	1.1	-0.4	-0.1	0.4	0.0
Lung FVC	0.9	4.7	8.1	2.8	1.2	-2.5	-0.9	-2.7
Neuroticism	0.5	1.2	4.1	-2.0	-0.4	1.0	-0.1	0.9
Chronotype (morning person)	1.6	3.8	7.9	2.8	2.5	-1.1	-1.8	-0.1
Hair Pigment	0.0	0.3	0.4	-0.5	0.4	0.5	0.7	-0.4
Tanning	0.3	3.3	6.4	0.1	-1.6	1.8	2.0	2.5
Hand grip strength (left)	1.2	3.2	5.3	-2.3	-1.8	1.7	1.4	1.6
Number of treatments/medications taken	2.2	4.0	8.7	2.9	2.3	-1.2	-1.7	-1.2
Average weekly spirits intake	0.9	1.1	2.1	-0.7	-0.5	1.5	1.3	1.1
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.3	0.3	0.0	-0.3	-0.3
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.5	-0.0	1.4	-1.2	-1.9	-1.2
Hearing difficulty/problems: Yes	3.7	5.6	8.4	1.7	2.1	-2.7	-2.3	-2.9
Relative age of first facial hair	0.2	0.3	0.7	-0.6	-0.6	0.2	0.8	-0.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.3	0.5	0.9	-1.5	-1.2	-1.1
Ever used hormone-replacement therapy (HRT)	6.2	7.9	11.9	3.5	3.0	-2.5	-3.1	-1.7
Ever had hysterectomy (womb removed)	5.7	6.4	8.9	2.5	3.0	-2.3	-2.6	-2.1
Systolic blood pressure, automated reading	0.1	0.4	1.1	1.0	-0.2	0.2	0.9	0.2
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	1.9	1.1	1.0	-1.3	-1.4	-1.2
Angina	0.1	0.2	0.3	0.6	0.0	-0.6	-0.5	0.4
Medication for hormone replacement therapy	4.8	5.4	6.6	2.3	2.2	-2.3	-2.2	-2.6
Vitamin and mineral supplements	0.0	0.0	0.1	-0.2	-0.1	-0.3	-0.1	-0.2
Supplements: Zinc	1.9	2.1	2.4	1.3	1.5	-1.5	-1.4	-1.6
Medication: Co-codamol	4.3	5.0	6.3	2.0	2.0	-2.5	-2.2	-2.4
Medication: Metformin	0.1	0.2	0.2	0.2	-0.4	0.5	0.4	0.5
Diabetes (father)	0.5	0.7	1.5	0.7	1.2	-0.7	-0.7	-0.7
Diabetes (mother)	0.2	0.2	0.4	0.1	0.5	-0.4	-0.6	-0.5
Severe depression (siblings)	2.9	3.3	4.4	1.0	1.8	-1.9	-2.1	-2.0
Pack years adult smoking proportion	1.5	2.2	2.9	1.2	1.4	-1.7	-1.6	-1.5
Impedance of leg (right)	0.8	3.7	7.0	0.3	0.8	-2.6	-2.4	-2.2
Leg fat-free mass (left)	0.6	3.3	5.9	-1.8	-0.7	2.4	1.4	2.2
Trunk fat percentage	0.1	0.4	0.8	-0.6	-0.0	0.8	0.1	0.9
Hand grip strength (right)	4.6	12.4	14.0	-3.6	-3.7	3.6	3.2	3.5
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.5	0.3	-0.5	-0.3	0.0
Current tobacco smoking	0.5	0.9	1.8	1.4	0.6	-1.1	-0.8	-0.6
Average weekly fortified wine intake	2.1	2.5	3.9	-2.0	-1.7	1.5	1.3	1.3
Maternal smoking around birth	0.8	1.2	2.3	0.6	0.9	-1.5	-1.1	-1.3
Fed-up feelings	0.1	0.2	0.6	0.0	0.2	-0.0	-0.8	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	2.4	0.2	1.2	-1.3	-1.6	-1.4
Relative age voice broke	0.1	0.2	0.8	0.9	-0.1	-0.1	0.4	-0.0
Taking other prescription medications	2.2	3.3	4.3	2.0	1.8	-1.8	-2.1	-1.4
Age when periods started (menarche)	6.2	14.9	25.2	-2.2	-4.3	3.5	5.0	3.7
Bilateral oophorectomy (both ovaries removed)	5.6	6.5	10.1	2.6	3.2	-2.2	-2.8	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	5.2	2.3	1.6	-1.6	-1.5	-1.4
Tinnitus: Yes, but not now, but have in the past	0.0	0.1	0.1	-0.3	-0.2	0.3	0.2	-0.0
Qualifications: CSEs or equivalent	1.9	2.5	4.2	-2.0	-1.6	1.5	1.3	1.5
Serious illness, injury or assault to yourself	5.0	6.1	7.5	2.0	2.6	-2.5	-2.7	-2.4
High blood pressure	0.4	1.0	1.8	0.2	-0.9	1.2	1.4	1.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.8	-0.6	0.5	-0.1	-0.1	-0.9
Multivitamins +/- minerals	0.0	0.0	0.1	0.3	-0.0	-0.1	0.1	-0.1
Stomach or abdominal pain in last month	2.1	2.7	4.2	0.9	1.9	-1.4	-2.0	-1.6
Supplements: Glucosamine	1.4	1.8	2.6	1.4	1.6	-1.1	-1.1	-1.4
Diverticular disease/diverticulitis (self-reported)	4.7	5.6	7.9	2.0	1.8	-2.8	-2.6	-2.5
Medication: Atenolol	0.2	0.3	1.4	1.2	-0.3	-0.2	-0.1	0.2
Medication: Levothyroxine sodium	1.8	3.1	5.3	-1.1	-2.3	1.4	2.0	1.9
Sitting height	1.4	10.0	23.9	-4.9	-2.4	3.0	1.9	2.9
Chronic bronchitis/emphysema (father)	0.9	1.0	1.7	-1.3	-1.3	0.5	1.1	0.6
High blood pressure (mother)	1.4	2.0	3.8	1.5	1.5	-1.0	-1.9	-0.7
Body mass index (BMI)	0.2	0.9	2.3	1.5	0.9	0.7	0.3	0.7
Impedance of leg (left)	1.0	4.8	8.4	0.3	1.1	-2.9	-2.7	-2.6
Leg predicted mass (left)	0.6	3.3	5.9	-1.8	-0.7	2.4	1.4	2.2
Trunk fat mass	0.2	1.0	2.0	-1.1	-0.2	1.4	0.4	1.4
Waist circumference	1.5	5.6	9.9	1.9	3.1	-1.9	-2.6	-2.2
Number of incorrect matches in round	2.5	4.2	6.1	-1.9	-1.9	2.2	1.7	2.5
Past tobacco smoking	0.2	0.3	1.3	-1.1	-0.1	-0.1	-0.3	-0.3
Alcohol usually taken with meals	0.2	0.3	0.9	0.4	0.3	-0.3	-1.0	0.3
Nervous feelings	0.2	0.4	1.4	-1.2	0.2	-0.2	-0.7	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.4	-0.5	0.2	-0.1	-1.2	0.1
Hearing difficulty/problems with background noise	1.2	1.9	2.8	0.5	1.5	-1.4	-1.5	-1.7
Hair/balding pattern: Pattern 2	1.1	1.4	3.6	-0.6	-0.6	1.3	0.9	1.9
Had menopause	0.1	0.2	0.6	0.8	-0.4	0.0	0.2	0.2
Had other major operations	1.4	1.7	2.4	1.3	1.5	-1.1	-1.5	-0.9
Forced vital capacity (FVC)	0.1	0.3	1.2	-1.1	-0.3	-0.0	-0.0	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.5	6.5	2.5	2.2	-2.0	-1.7	-2.0
Ever unenthusiastic/disinterested for a whole week	2.7	3.4	4.1	1.7	2.0	-1.8	-1.9	-1.6
Qualifications: None of the above	0.8	1.7	3.0	-0.6	-1.1	1.3	1.4	1.7
Financial difficulties in last 2 years	3.2	4.4	4.9	1.8	2.2	-2.2	-2.2	-2.1
Mouth/teeth dental problems	0.1	0.1	0.2	0.5	0.1	0.4	0.2	0.5
Heart attack	0.3	0.3	0.6	0.7	-0.7	-0.1	0.1	0.8
Allergy	0.2	0.5	1.9	1.4	-0.0	-0.6	-0.3	0.2
Pain all over the body in last month	0.1	0.1	0.2	-0.3	-0.3	-0.0	-0.4	0.2
Diabetes (self-reported)	0.1	0.2	0.7	0.8	-0.3	-0.3	0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.2	-0.4	-0.4	0.4	0.5	0.3
Medication: Ramipril	0.1	0.1	0.4	-0.1	-0.6	0.1	0.4	0.3
Medication: Simvastatin	0.8	1.2	2.5	-0.2	-0.8	1.4	0.9	1.6
Fluid intelligence score	0.1	0.1	0.5	0.7	0.1	-0.0	0.3	-0.3
Illnesses of siblings	0.1	0.1	0.2	0.1	0.3	-0.3	-0.3	-0.5
Neuroticism score	0.2	0.4	1.3	-1.1	0.1	0.5	-0.6	0.4
Weight	0.3	1.6	3.3	-1.1	-0.2	1.8	0.8	1.7
Impedance of arm (right)	0.3	1.6	5.2	-2.3	-0.7	-0.9	-0.8	-0.8
Arm fat percentage (right)	0.1	0.3	0.6	0.4	0.6	0.7	0.2	0.8
Trunk fat-free mass	0.4	2.4	4.2	-1.7	-0.7	2.1	1.2	1.6
Hip circumference	0.7	2.9	5.4	-0.9	-1.1	2.3	1.9	2.0
Time employed in main current job	1.2	1.4	2.3	1.3	1.5	-1.1	-1.1	-0.8
Alcohol intake versus 10 years previously	0.9	1.3	2.6	-0.6	-1.4	0.9	1.6	0.9
Father’s age at death	0.4	0.6	0.9	-1.0	-0.9	0.6	0.8	0.3
Worrier / anxious feelings	1.0	1.9	4.4	0.5	1.1	-1.5	-2.1	-1.2
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.1	7.3	1.4	2.2	-1.8	-2.7	-1.8
Falls in the last year	2.3	3.1	3.6	1.6	1.9	-1.6	-1.8	-1.9
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.9	0.4	-0.6	-0.6	-0.1
Number of live births	0.3	0.5	1.4	1.2	0.2	-0.8	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.5	-0.1	-0.3	-0.2	-0.3
Pulse rate	2.5	4.2	5.8	0.8	2.2	-2.1	-2.4	-2.3
Happiness	3.4	4.1	5.8	-2.4	-1.8	2.2	1.2	2.3
Noisy workplace	0.6	0.7	1.3	-0.6	-1.1	0.7	1.1	0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	0.0	-0.3	0.2	0.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	2.6	0.8	1.3	-1.3	-1.6	-1.4
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.1	0.0
Asthma	0.2	0.4	1.3	0.2	1.1	-0.5	-0.6	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.8	0.2	0.2	0.9	-0.2	0.9
Medication: Cholesterol lowering	1.2	1.8	3.9	0.3	-1.4	1.5	1.0	2.0
Depression (self-reported)	0.6	0.7	2.0	0.5	0.7	-0.7	-1.4	-0.3
Medication: Lansoprazole	2.8	3.2	4.5	1.8	2.1	-1.4	-2.0	-1.5
Prospective memory result	0.3	0.4	1.3	-1.2	-0.3	0.4	-0.5	0.6
Lung cancer (father)	0.1	0.1	0.3	-0.3	-0.3	0.3	0.5	0.0
Illnesses of mother	0.1	0.1	0.3	0.1	-0.1	-0.5	0.1	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	0.0	0.4	-0.7	-0.7	-0.7
Pulse wave Arterial Stiffness index	0.5	0.6	0.9	0.8	0.6	-0.7	-0.7	-1.0
Impedance of arm (left)	0.4	1.8	6.9	-2.6	-1.1	-0.5	-0.5	-0.3
Arm fat mass (right)	0.1	0.4	1.0	0.0	0.6	1.0	0.3	0.9
Trunk predicted mass	0.4	2.5	4.3	-1.8	-0.7	2.1	1.3	1.7
Standing height	0.8	8.4	28.6	-5.3	-2.0	2.2	0.9	1.9
Length of working week for main job	0.3	0.3	1.0	-0.7	0.0	0.4	0.3	1.0
Exposure to tobacco smoke at home	1.3	1.5	2.4	-1.6	-1.1	1.3	1.0	0.9
Breastfed as a baby	4.9	6.1	9.5	-2.2	-2.9	2.2	3.1	1.8
Tense / ‘highly strung’	0.1	0.2	0.6	-0.8	0.0	0.4	-0.6	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	0.4	0.3	-0.6	-0.0
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.3	-0.7	0.6	0.7	0.6
Birth weight of first child	0.4	0.7	1.7	-1.3	-0.5	0.7	0.7	0.6
Peak expiratory flow (PEF)	0.3	0.7	1.4	-1.2	-0.9	0.7	0.6	0.6
Pulse wave reflection index	0.2	0.3	0.7	0.1	-0.1	0.8	0.4	0.8
Ever highly irritable/argumentative for 2 days	1.4	1.6	2.5	1.6	1.1	-1.2	-1.2	-1.3
Loud music exposure frequency	0.2	0.3	0.6	-0.3	-0.8	0.5	0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.2	-1.5	-0.8	1.0	0.8	0.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.8	-0.3	0.5	-1.2	-1.1	-1.7
Blood clot in the leg (DVT)	0.3	0.3	0.7	-0.3	0.6	-0.4	-0.8	-0.6
Medication: Paracetamol	3.5	5.8	8.6	1.6	2.9	-2.2	-2.7	-2.4
Headache pain in last month	0.3	0.5	1.4	-0.8	0.7	-0.1	-1.2	0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.3	-0.0	1.0	-1.1	-1.0	-1.8
Glaucoma (self-reported)	2.2	2.5	3.0	1.3	1.5	-1.7	-1.7	-1.7
Gout (self-reported)	0.6	0.8	1.5	0.5	0.9	-0.6	-0.9	-1.2
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	4.1	-1.0	-2.0	1.7	2.0	1.7
Medication: Amlodipine	0.8	1.2	3.4	1.9	0.7	-1.1	-0.8	-0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.2	1.9	1.3	1.4	-0.8	-1.1	-0.8
Birth weight	0.4	0.8	2.9	-1.7	-0.5	0.8	0.5	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.8	-0.9	-0.5	-0.1	0.3	-0.2
High blood pressure (siblings)	0.2	0.3	0.3	0.6	0.6	-0.6	-0.4	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.3	0.6	-0.8	0.3	-0.5	-0.5	-0.6
Body fat percentage	0.1	0.2	0.5	0.2	0.5	0.5	-0.1	0.7
Leg fat percentage (right)	0.2	0.9	2.8	1.7	1.2	-0.1	-0.5	0.3
Arm fat-free mass (right)	0.4	2.2	4.2	-1.4	-0.4	2.1	1.1	1.8
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.6	-0.2	0.8	0.6	0.8
Comparative body size at age 10	1.0	2.8	3.6	1.7	1.9	-1.4	-1.6	-1.7
Number of full brothers	0.2	0.3	1.2	0.5	-0.1	0.2	0.0	1.1
Worry too long after embarrassment	3.2	5.4	8.7	1.7	2.5	-2.3	-3.0	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.3	4.7	0.6	1.6	-1.4	-2.2	-1.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	-0.5	0.8	-0.3	-0.9	0.1
Number of children fathered	0.3	0.3	0.7	0.8	0.6	-0.2	-0.6	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.7	-1.6	-0.4	0.7	0.3	0.9
Age at first live birth	0.4	0.7	1.3	-1.1	-1.1	0.6	0.9	0.2
Pulse wave peak to peak time	0.8	1.0	1.5	-1.2	-0.8	0.9	0.8	1.2
Health satisfaction	1.2	1.5	2.3	1.3	1.2	-1.1	-1.5	-1.0
Shortness of breath walking on level ground	0.1	0.2	0.5	-0.2	-0.2	0.7	0.3	0.5
Qualifications: College or University degree	0.7	2.1	3.5	0.1	1.4	-1.4	-1.9	-1.7
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.1	-0.7	0.2	0.7	-0.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.4	-0.4	0.2	0.2	0.4
Emphysema/chronic bronchitis	1.0	1.1	2.1	-1.1	-1.4	0.7	1.2	0.5
Medication for pain relief, constipation, heartburn	1.8	3.0	5.7	-1.6	-2.1	1.1	2.4	1.0
Neck or shoulder pain in last month	2.1	2.9	3.7	1.5	1.8	-1.7	-1.6	-1.9
Medication: Blood pressure	1.0	1.7	3.0	-0.4	-1.4	1.3	1.3	1.7
Angina (self-reported)	0.2	0.3	0.6	0.8	0.1	-0.7	-0.6	0.3
Migraine (self-reported)	2.0	2.5	5.2	-2.3	-1.5	1.4	1.6	0.9
Medication: Ibuprofen	0.3	0.4	0.7	0.6	0.3	0.8	-0.0	0.8
Medication: Allopurinol	0.4	0.5	0.7	0.5	0.8	-0.6	-0.7	-0.8
Medication: Omeprazole	6.7	8.0	10.6	2.9	3.3	-2.5	-2.8	-2.6
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.4	0.6	-0.4	-0.3	-0.6
Mean time to correctly identify matches	1.1	2.2	3.0	-1.1	-1.7	1.2	1.6	1.5
Heart disease (mother)	0.3	0.4	1.2	1.1	0.8	-0.0	-0.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	0.5	-0.7	0.3	0.7	0.4
Whole body fat mass	0.1	0.4	1.0	-0.3	0.4	0.9	0.2	1.0
Leg fat mass (right)	0.1	0.5	0.8	0.7	0.8	0.7	-0.0	0.9
Arm predicted mass (right)	0.4	2.2	4.0	-1.4	-0.6	2.0	1.2	1.8
Pulse rate, automated reading	4.9	15.7	23.5	2.7	3.9	-4.1	-4.0	-4.8
Alcohol intake frequency.	0.3	0.6	0.8	0.5	0.8	-0.8	-0.9	-0.9
Comparative height size at age 10	0.3	1.8	6.9	-2.6	0.6	-0.2	-1.1	-0.4
Number of full sisters	0.1	0.2	0.2	-0.4	-0.5	0.1	0.4	0.4
Suffer from ‘nerves’	0.8	1.3	4.3	-2.1	-0.7	1.1	0.3	0.6
Overall health rating	2.6	5.5	7.7	2.0	2.2	-2.7	-2.8	-2.0
Chest pain or discomfort	0.1	0.2	0.8	-0.9	-0.2	-0.0	-0.1	-0.5
Had major operations	0.3	0.3	1.1	0.3	-0.3	-0.5	0.2	-1.1
Age at last live birth	0.2	0.2	0.4	-0.6	-0.6	0.1	0.6	-0.1
Family relationship satisfaction	0.4	0.5	1.8	-1.3	-0.4	0.4	-0.5	-0.2
Leg pain on walking	0.3	0.3	0.7	0.8	0.2	-0.6	-0.5	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	0.7	0.5	-0.5	-0.4	-0.7
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.2	-0.9	-0.9	1.5	1.4	1.4
Illness, injury, bereavement, stress in last 2 years	3.6	4.3	6.4	-1.5	-2.3	1.9	2.5	2.1
Medication: Aspirin	0.5	0.6	1.5	0.5	-0.4	1.0	0.2	1.2
Supplements: Vitamin C	0.1	0.1	0.6	0.7	-0.0	-0.1	-0.3	-0.1
Knee pain experienced in last month	0.8	1.3	2.7	1.6	1.1	-0.9	-1.2	-0.7
Hypertension (Self-reported)	0.3	0.9	1.6	0.5	-0.9	1.0	1.3	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.6	0.1	0.7	-0.5	-0.2	-0.8
Illnesses of father: Heart disease	0.2	0.3	1.5	1.2	-0.2	-0.1	0.0	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.1	-0.3	-0.4	0.0	-0.5
Smoking status: Previous	0.2	0.2	0.8	0.9	0.3	0.1	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	8.2	-2.9	-1.1	1.1	1.0	0.7
Whole body fat-free mass	0.5	2.6	4.7	-1.8	-0.6	2.2	1.2	1.8
Leg fat-free mass (right)	0.5	2.6	4.9	-1.8	-0.4	2.2	1.2	1.8
Arm fat percentage (left)	0.1	0.4	1.0	0.1	0.4	0.9	0.4	1.0
Average weekly red wine intake	0.7	1.0	3.0	-0.4	-0.3	1.3	0.4	1.7
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.2	-0.0	-0.1	0.4	0.1	-0.1
Mood swings	1.0	1.8	4.1	-2.0	-1.0	1.3	0.5	1.3
Loneliness, isolation	0.8	1.0	2.3	-1.5	-0.6	1.0	0.4	1.2
Long-standing illness, disability or infirmity	5.7	8.8	9.5	3.0	3.1	-2.9	-3.1	-2.8
Ever had bowel cancer screening	0.1	0.2	0.4	0.6	0.3	-0.3	-0.5	-0.2
Diabetes diagnosed by doctor	0.3	0.4	1.9	1.4	0.1	-0.4	-0.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.0	1.0	0.9	-0.9	-0.9	-0.6
Friendships satisfaction	3.3	4.1	7.8	-2.8	-2.0	2.0	1.4	1.6
Qualifications: nursing, teaching	0.6	0.9	1.4	1.0	1.1	-0.6	-1.2	-0.7
Commuting to job workplace: Walk	1.7	1.9	3.4	1.2	0.9	-1.6	-1.0	-1.8
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.5	0.1	-0.1	-0.5	0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	-0.2	0.3	-0.1	-0.0	-0.4
Medication for cholesterol	7.7	11.8	14.6	-3.8	-3.5	3.3	2.8	3.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.0	-1.3	-0.8	1.1	0.4	1.4
Back pain experienced in last month	1.7	2.4	3.3	1.4	1.7	-1.6	-1.0	-1.8
Mineral and other dietary supplements	1.1	1.5	2.6	-1.6	-1.6	0.7	1.1	1.0
Breast cancer (self-reported)	0.2	0.2	0.4	0.6	0.3	-0.3	-0.3	-0.5
Asthma (self-reported)	0.2	0.3	1.1	-0.0	1.1	-0.4	-0.5	-0.4
Osteoporosis (self-reported)	0.4	0.5	1.1	0.6	0.1	-1.0	-0.6	-0.7
Osteoarthritis (self-reported)	1.0	1.3	2.3	1.5	1.4	-0.7	-1.2	-0.5
Medication: Aspirin	0.5	0.6	1.5	0.5	-0.6	1.0	0.3	1.2
Medication: Gliclazide	0.1	0.1	0.3	0.5	0.2	-0.2	-0.5	0.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.8	0.5	1.3	-0.6	-1.2	-0.7
Smoking status: Current	0.5	0.7	1.7	1.3	0.5	-1.0	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.9	1.4	0.3	-1.2	-0.7	-0.9
Whole body water mass	0.4	2.5	4.6	-1.7	-0.5	2.1	1.2	1.8
Leg predicted mass (right)	0.4	2.4	4.6	-1.7	-0.4	2.1	1.1	1.8
Arm fat mass (left)	0.2	0.7	1.6	-0.1	0.4	1.3	0.5	1.2
Number of self-reported non-cancer illnesses	0.6	1.0	1.9	1.4	1.2	-0.8	-0.8	-0.5
Average weekly champagne plus white wine intake	1.3	1.8	3.0	-0.1	-1.6	1.4	1.4	1.7
Miserableness	0.3	0.6	1.0	-0.5	-0.3	1.0	0.7	1.0
Guilty feelings	0.3	0.5	1.6	-1.3	-0.6	0.5	0.1	0.5
Wears glasses or contact lenses	5.2	6.0	9.9	-1.3	-2.7	2.5	3.1	2.2
Ever taken oral contraceptive pill	0.6	0.6	1.4	0.8	1.2	-0.4	-0.8	-0.5
Hearing aid user	0.3	0.4	1.1	1.0	0.7	-0.5	-0.1	-0.2
Mother’s age at death	3.5	4.4	6.2	-2.5	-2.4	1.8	2.4	1.1
Financial situation satisfaction	0.0	0.0	0.1	0.0	-0.0	-0.0	-0.2	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.6	0.1	0.3	0.2	-0.2
Commuting to job workplace: Public transport	0.7	0.9	1.8	0.5	1.1	-0.7	-1.4	-0.8
Eye problems/disorders: Glaucoma	0.6	0.7	1.7	0.5	0.7	-1.0	-0.5	-1.3
Medication: Blood pressure	0.9	1.8	3.4	1.8	1.3	-1.0	-0.4	-1.6
Pain type(s) experienced in last month: Hip pain	3.8	4.8	6.7	2.4	2.6	-1.5	-2.4	-1.8
Supplements: Fish oil (including cod liver oil)	0.6	0.7	2.0	1.4	1.0	-0.3	-0.7	-0.4
High cholesterol (Self-reported)	0.2	0.3	0.5	0.7	0.1	0.6	0.5	0.6
Medication: Bendroflumethiazide	0.3	0.4	1.7	1.3	0.2	-0.5	-0.1	-0.3
Medication: Paracetamol	1.8	2.8	4.8	1.3	2.2	-1.3	-1.7	-1.7
Medication: Lisinopril	0.2	0.2	0.9	1.0	0.2	0.2	0.0	0.3
Medication: Atorvastatin	0.9	1.1	2.0	1.4	0.8	-1.0	-0.6	-1.2
Illnesses of father: High blood pressure	0.8	1.0	2.6	-0.8	-1.2	0.5	1.6	0.0
Alcohol drinker status: Never	0.3	0.3	0.5	0.7	0.5	-0.2	-0.7	0.6
Ever smoked	0.3	0.5	1.4	0.6	-0.5	0.6	1.2	0.4
Basal metabolic rate	0.4	2.1	4.0	-1.5	-0.3	2.0	1.0	1.7
Leg fat percentage (left)	0.2	0.8	2.3	1.5	1.2	-0.1	-0.5	0.2
Arm fat-free mass (left)	0.3	1.3	2.9	-1.1	0.0	1.7	0.7	1.4
Number of operations (self-reported)	0.8	1.1	1.5	0.9	1.2	-1.1	-1.1	-0.9
Average weekly beer plus cider intake	1.3	1.9	2.9	-1.7	-1.5	1.0	1.7	0.5
Irritability	1.5	2.6	5.7	-0.8	-1.0	2.1	1.1	2.4
Risk taking	1.9	2.8	4.9	1.4	2.1	-1.3	-2.2	-1.1
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.9	-0.8	-1.1	1.8	1.4	2.0
Fractured/broken bones in last 5 years	0.2	0.2	0.7	0.2	0.1	-0.7	-0.1	-0.8
Age started oral contraceptive pill	0.1	0.2	0.3	-0.6	-0.3	0.4	0.5	-0.0
Diastolic blood pressure, automated reading	1.0	3.0	4.4	1.1	2.0	-1.6	-1.6	-2.1
Ever depressed for a whole week	1.0	1.3	1.8	0.9	1.1	-1.0	-1.3	-1.2
Unable to work because of sickness or disability	1.6	2.1	3.8	0.9	1.3	-1.7	-1.1	-1.9
Commuting to job workplace: Cycle	1.5	1.8	3.6	-0.5	-1.8	1.0	1.9	0.9
Myopia	0.3	0.4	0.8	0.9	0.3	-0.7	-0.4	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.8	-0.5	0.6	-0.7	-0.8	-0.9
Cholesterol lowering medication	0.8	1.1	1.7	1.1	1.3	-0.9	-0.8	-1.2
Medication: Omeprazole (e.g. Zanprol)	6.7	8.1	10.6	2.8	3.2	-2.4	-2.8	-2.8
Pain experienced in last month	2.4	4.1	6.5	-1.6	-2.6	1.7	2.1	2.0
Supplements: Calcium	0.1	0.1	0.2	0.3	0.4	-0.4	-0.4	-0.4
Basal cell carcinoma (self-reported)	2.7	3.2	5.0	0.9	2.1	-1.6	-2.2	-1.8
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	0.9	-0.4	-0.3	-0.3	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.6	-0.5	0.6	-0.4	-0.8	-0.6
Heart disease (siblings)	0.1	0.1	0.4	0.2	-0.1	0.3	-0.2	0.7
Alcohol drinker status: Previous	0.7	0.8	1.5	1.2	1.0	-0.4	-1.1	-0.4
Pack years of smoking	0.5	0.8	1.0	0.8	0.8	-1.0	-0.9	-0.8
Impedance of whole body	0.4	2.1	2.9	-1.6	-0.2	-1.7	-1.7	-1.5
Leg fat mass (left)	0.1	0.5	0.8	0.6	0.9	0.7	-0.1	0.9
Arm predicted mass (left)	0.2	1.0	2.5	-0.9	0.1	1.6	0.7	1.2