Hub : Genes

BCAS2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.046	0.017	9.4e-05	0.017	0.030	0.016	0.029	0.016	0.0029	0.00011	0.0041	0.00015	0.0045
2	GTEx	Esophagus Muscularis	0.096	0.040	4.7e-03	-0.001	NA	-0.003	NA	-0.005	0.3500	NA	0.5100	NA	0.9900
3	TCGA	Breast Invasive Carcinoma	0.015	0.009	4.9e-03	0.012	0.007	0.010	NA	0.008	0.0015	0.01000	0.0033	NA	0.0064

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.2	2.0	2.6	1.5	-1.1	1.6
Bipolar Disorder or Schizophrenia	0.8	1.8	2.3	1.3	-1.5	1.3
Depressed Affect (Nagel 2018)	0.9	1.9	3.1	-1.6	-0.1	-1.8
Depression (Nagel 2018)	2.2	3.3	5.2	-1.5	-1.6	-2.3
Intelligence (Savage-Jansen 2018)	0.0	0.2	0.4	0.3	-0.2	-0.6
Neuroticism (Nagel 2018)	1.1	2.5	3.9	-1.6	-0.9	-2.0
Schizophrenia (2018)	0.2	0.5	1.2	0.4	-1.1	0.3
Schizophrenia vs Biploar Disorder	0.5	0.6	0.9	-0.9	-0.8	-0.6
Worry (Nagel 2018)	0.6	1.2	1.7	-1.2	-0.8	-1.3
Alzheimer’s Disease (in mother)	0.7	0.8	1.0	1.0	0.9	0.9
Alzheimer’s Disease (in father)	0.6	0.7	1.7	-0.0	1.3	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	0.5	1.5	0.5
Crohns Disease (2017)	0.2	0.4	1.1	0.3	-1.0	0.4
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.5	-0.1	0.7
Ulcerative Colitis (UC)	0.4	0.7	1.3	0.3	1.1	0.8
Major Depression (MDD)	1.6	1.9	2.3	-1.3	-1.3	-1.5
Reaction Time	0.9	1.7	3.6	-1.9	0.9	-0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.8	-0.1	0.4	-0.9
Breast Cancer	0.1	0.3	0.6	-0.8	-0.4	-0.2
Ovarian Cancer	0.7	1.0	2.8	0.2	0.2	1.7
Prostate Cancer	0.2	0.3	0.7	0.6	0.0	0.8
Age at First Birth	0.3	0.4	1.0	-0.4	0.3	1.0
Bipolar Disorder (2011)	0.4	0.4	1.1	-0.0	-1.1	0.3
Body Mass Index (BMI) (2010)	0.3	0.3	0.4	-0.7	-0.6	-0.4
Coronary Artery Disease (CAD)	0.6	0.7	1.2	-0.9	1.1	0.2
Crohns Disease (2012)	0.3	0.5	1.0	1.0	-0.6	-0.0
Mean Putamen Volume	0.8	0.9	1.1	0.9	-1.1	0.9
Fasting Glucose	0.7	0.8	1.2	0.7	-1.1	1.0
HbA1C	0.1	0.1	0.2	0.5	0.0	-0.4
HDL Cholesterol	0.1	0.2	0.5	0.2	0.7	0.3
LDL Cholesterol	0.4	0.7	0.9	-0.8	1.0	-0.7
Lupus	0.2	0.2	0.7	-0.2	0.8	-0.0
Neuroticism (2016)	3.1	4.4	6.8	-2.0	-1.5	-2.6
Primary Biliary Cirrhosis	0.4	0.6	0.8	0.9	-0.4	0.9
Rheumatoid Arthritis	0.4	0.6	1.1	0.6	1.1	0.5
Schizophrenia (2014)	0.7	1.5	3.2	0.9	-1.8	0.6
Triglycerides	0.1	0.2	0.5	-0.2	0.7	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.6	-0.6	0.7	-0.6
Ulcerative Colitis	0.2	0.3	0.6	0.4	0.7	0.5
Blood Eosinophil Count	0.5	3.9	7.8	-2.8	1.3	-1.5
Blood Platelet Count	0.1	1.6	4.8	-0.2	2.2	-0.2
Blood Red Count	0.9	9.0	24.6	-1.4	5.0	0.7
Blood White Count	1.1	7.9	12.0	-2.4	-3.5	-2.5
Heel T-Score	0.4	3.2	4.9	-2.1	-0.1	-2.2
BMI	0.2	1.1	2.7	0.8	0.0	1.6
Height	0.4	7.3	9.1	-2.7	-3.0	-2.4
Waist Hip Ratio (WHR)	4.2	18.7	22.9	3.3	4.7	4.8
Systolic Blood Pressure	0.5	2.4	3.5	-1.9	-1.1	-1.6
Smoking Status	0.6	1.5	2.8	-0.9	1.7	-1.0
Allergy or Eczema	0.8	2.1	4.3	-2.1	-0.3	-1.4
Cardiovascular Disease	0.4	1.2	3.5	-0.2	1.9	0.2
Hypothyroidism (self reported)	0.3	0.8	1.9	1.4	0.3	0.6
Respiratory disease	0.1	0.2	0.4	-0.5	-0.1	-0.6
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.0	1.4	-0.3	1.4
Lung FEV1/FVC ratio	0.8	4.2	11.2	-0.2	3.4	1.1
Lung FVC	1.7	8.4	15.2	3.9	-0.9	3.0
Neuroticism	1.5	3.6	5.6	-2.0	-1.0	-2.4
Chronotype (morning person)	5.9	13.7	34.5	2.5	-5.9	0.5
Hair Pigment	0.1	1.7	4.0	1.0	0.3	2.0
Tanning	0.1	0.9	1.9	-1.4	0.8	0.4
Hand grip strength (left)	0.1	0.3	0.6	-0.3	-0.7	-0.5
Number of treatments/medications taken	0.2	0.3	0.7	-0.4	0.8	-0.1
Average weekly spirits intake	0.0	0.0	0.1	0.3	0.1	0.1
Sensitivity / hurt feelings	0.7	1.1	2.5	-1.6	-0.3	-0.9
Frequency of depressed mood in last 2 weeks	2.0	2.8	3.8	-1.8	-1.2	-1.9
Hearing difficulty/problems: Yes	0.1	0.2	0.2	-0.3	-0.5	-0.4
Relative age of first facial hair	1.2	2.5	3.2	1.4	-1.5	1.8
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.1	-1.4	-0.4	-1.8
Ever used hormone-replacement therapy (HRT)	0.0	0.1	0.1	-0.1	-0.3	-0.3
Ever had hysterectomy (womb removed)	1.9	2.2	6.4	0.0	-2.5	-0.3
Systolic blood pressure, automated reading	1.0	2.8	5.4	-1.2	-2.3	-1.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	0.1	0.8	0.3
Angina	0.3	0.4	1.1	-0.5	-0.1	-1.0
Medication for hormone replacement therapy	1.1	1.2	2.0	1.1	1.4	0.4
Vitamin and mineral supplements	0.5	0.7	1.7	1.3	-0.0	0.6
Supplements: Zinc	0.6	0.6	1.4	0.6	1.2	0.3
Medication: Co-codamol	1.2	1.4	3.4	0.7	-1.8	-0.5
Medication: Metformin	0.5	0.7	1.2	1.0	-0.1	1.1
Diabetes (father)	2.0	2.5	3.3	1.7	1.1	1.8
Diabetes (mother)	0.1	0.1	0.2	-0.2	-0.4	-0.3
Severe depression (siblings)	0.1	0.2	0.2	0.1	-0.5	0.5
Pack years adult smoking proportion	0.3	0.4	0.6	0.7	-0.8	0.5
Impedance of leg (right)	0.0	0.2	0.5	0.0	0.7	-0.3
Leg fat-free mass (left)	0.3	1.7	2.7	-1.4	-1.6	-0.8
Trunk fat percentage	0.0	0.1	0.4	0.0	-0.1	0.6
Hand grip strength (right)	0.2	0.6	1.3	-0.2	-1.1	-0.6
Townsend deprivation index at recruitment	0.6	0.8	1.3	-0.5	-0.9	-1.1
Current tobacco smoking	0.0	0.0	0.0	0.1	-0.0	0.0
Average weekly fortified wine intake	2.6	3.0	5.7	-2.4	1.4	-1.2
Maternal smoking around birth	0.4	0.6	1.8	-0.2	1.4	0.1
Fed-up feelings	1.6	3.0	3.3	-1.7	-1.8	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.5	-0.8	-1.2	-1.6
Relative age voice broke	0.2	0.3	0.7	-0.2	-0.8	-0.4
Taking other prescription medications	2.5	3.8	7.7	-1.9	0.3	-2.8
Age when periods started (menarche)	1.6	3.8	6.6	-2.6	-0.9	-2.0
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.3	-0.9	-1.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	-0.6	1.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.9	0.1	0.4
Qualifications: CSEs or equivalent	1.5	2.0	5.4	0.1	-2.3	-0.7
Serious illness, injury or assault to yourself	2.3	2.8	5.9	-1.5	0.7	-2.4
High blood pressure	0.3	0.8	1.2	-1.0	1.1	0.3
Hayfever, allergic rhinitis or eczema	0.9	1.9	4.0	-2.0	0.1	-1.3
Multivitamins +/- minerals	0.5	0.6	1.3	-1.1	0.4	-0.6
Stomach or abdominal pain in last month	1.1	1.3	2.6	-1.0	0.6	-1.6
Supplements: Glucosamine	1.7	2.2	3.6	-1.6	-0.6	-1.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	-0.9	-0.6	-0.3
Medication: Atenolol	1.2	1.5	2.2	-1.3	1.5	-0.7
Medication: Levothyroxine sodium	0.8	1.3	1.8	1.3	0.5	1.3
Sitting height	0.8	6.0	8.4	-1.5	-2.7	-2.9
Chronic bronchitis/emphysema (father)	0.8	0.9	2.1	-0.1	-1.4	-0.8
High blood pressure (mother)	0.3	0.4	0.7	-0.0	-0.9	-0.6
Body mass index (BMI)	0.1	0.3	0.4	-0.6	-0.4	0.6
Impedance of leg (left)	0.1	0.3	0.6	-0.1	0.7	-0.7
Leg predicted mass (left)	0.3	1.6	2.5	-1.4	-1.6	-0.7
Trunk fat mass	0.1	0.3	0.6	-0.8	-0.4	0.2
Waist circumference	0.4	1.6	3.4	0.3	1.2	1.8
Number of incorrect matches in round	1.1	1.8	2.5	-1.3	1.6	-1.1
Past tobacco smoking	0.2	0.3	0.6	0.6	-0.3	0.7
Alcohol usually taken with meals	0.2	0.3	0.5	-0.7	0.3	-0.5
Nervous feelings	0.6	1.1	2.0	-1.4	-0.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.0	5.4	-0.3	-2.3	-1.9
Hearing difficulty/problems with background noise	0.3	0.4	0.9	0.6	1.0	0.1
Hair/balding pattern: Pattern 2	0.9	1.1	2.7	-0.7	-1.7	-0.4
Had menopause	0.1	0.2	0.4	-0.1	-0.6	0.3
Had other major operations	1.3	1.6	2.0	1.4	-1.0	1.3
Forced vital capacity (FVC)	0.6	2.2	3.1	1.6	-1.8	1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	6.4	-0.9	2.5	-0.6
Ever unenthusiastic/disinterested for a whole week	0.9	1.2	1.7	1.2	-1.3	0.5
Qualifications: None of the above	0.5	1.0	1.2	-1.1	-1.1	-0.9
Financial difficulties in last 2 years	0.9	1.2	1.6	1.0	-1.2	-1.1
Mouth/teeth dental problems	0.7	1.0	1.5	1.2	0.4	1.2
Heart attack	0.6	0.7	2.1	-0.1	1.4	-0.2
Allergy	0.7	1.5	3.1	1.8	-0.6	1.0
Pain all over the body in last month	0.3	0.3	0.5	-0.7	-0.5	-0.3
Diabetes (self-reported)	0.6	1.0	2.4	0.4	-0.6	1.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.4	-1.5	1.2	-0.8
Medication: Ramipril	0.4	0.5	0.9	-0.0	0.9	0.9
Medication: Simvastatin	0.3	0.5	0.9	-0.7	1.0	-0.1
Fluid intelligence score	0.1	0.2	0.4	0.1	0.6	-0.4
Illnesses of siblings	6.8	9.6	15.8	2.4	2.7	4.0
Neuroticism score	0.8	1.7	2.3	-1.5	-1.0	-1.4
Weight	0.3	1.5	2.6	-1.6	-1.3	-0.6
Impedance of arm (right)	0.3	1.3	3.2	1.8	0.6	0.5
Arm fat percentage (right)	0.0	0.2	0.5	-0.1	0.1	0.7
Trunk fat-free mass	0.7	4.1	7.9	-2.8	-1.3	-1.7
Hip circumference	0.2	0.8	1.6	-1.3	-0.8	-0.1
Time employed in main current job	0.2	0.2	0.4	-0.3	0.6	0.4
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.6	0.1	-0.7
Father’s age at death	0.5	0.7	1.3	0.8	0.4	1.1
Worrier / anxious feelings	0.1	0.3	0.8	-0.1	-0.9	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	6.9	0.4	-1.3	-2.6
Falls in the last year	0.2	0.3	0.5	0.6	-0.1	-0.7
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	-0.7	0.9	0.3
Number of live births	0.7	1.1	1.6	-1.1	-0.5	-1.3
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.3	1.8	-0.8	1.4
Pulse rate	1.1	1.9	3.9	2.0	0.4	1.3
Happiness	1.1	1.3	2.6	1.0	-1.6	-0.7
Noisy workplace	0.8	0.9	1.8	1.3	-0.6	0.8
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	0.1	0.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.2	-1.5	0.0	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.3	-0.3	-0.4
Asthma	0.2	0.4	0.6	-0.8	0.6	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.5	0.7	-1.2	-0.6
Medication: Cholesterol lowering	0.4	0.7	1.3	0.8	0.4	1.1
Depression (self-reported)	0.3	0.4	0.4	0.6	0.5	0.6
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	0.4	0.1
Prospective memory result	3.6	4.4	6.8	-2.3	2.6	-1.1
Lung cancer (father)	0.4	0.5	1.0	-1.0	0.2	-0.6
Illnesses of mother	0.5	0.7	1.0	0.2	1.0	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.1	2.0	0.2	1.3
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.1	0.1	0.2
Impedance of arm (left)	0.5	2.2	4.5	2.1	0.9	1.1
Arm fat mass (right)	0.1	0.4	0.7	-0.7	-0.8	0.3
Trunk predicted mass	0.8	4.3	8.2	-2.9	-1.3	-1.7
Standing height	0.5	4.7	6.0	-2.3	-1.6	-2.5
Length of working week for main job	0.8	0.9	1.5	0.7	1.2	0.9
Exposure to tobacco smoke at home	0.8	0.9	1.7	-0.7	-0.8	-1.3
Breastfed as a baby	3.6	4.4	6.3	-2.5	-1.4	-2.3
Tense / ‘highly strung’	0.4	0.7	1.9	0.4	-1.4	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.5	0.9	-1.9	-0.7
Hair/balding pattern: Pattern 4	1.2	3.0	3.8	1.5	2.0	1.7
Birth weight of first child	0.1	0.2	0.3	-0.6	0.4	-0.3
Peak expiratory flow (PEF)	0.1	0.3	0.6	0.8	-0.3	0.3
Pulse wave reflection index	0.2	0.3	0.7	-0.2	-0.3	0.9
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	-0.1	-0.6	-0.4
Loud music exposure frequency	0.6	0.7	2.0	1.4	-0.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.2	1.5	0.0	0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.5	0.0	0.6
Blood clot in the leg (DVT)	1.2	1.6	3.2	1.8	0.5	1.2
Medication: Paracetamol	1.1	1.8	3.6	0.9	-1.9	0.9
Headache pain in last month	0.8	1.4	3.7	-0.5	-0.4	-1.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.7	0.3	-1.9	-0.4
Glaucoma (self-reported)	1.2	1.4	3.3	-1.0	-0.1	-1.8
Gout (self-reported)	0.6	0.8	2.0	-0.5	1.4	-0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.8	0.9	0.4	0.3
Medication: Amlodipine	1.6	2.2	3.2	1.8	0.3	1.8
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.0	-0.6	-0.5
Birth weight	0.2	0.4	1.0	0.3	-1.0	-0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.3	-0.3	-0.6
High blood pressure (siblings)	3.6	5.2	8.5	-1.1	-2.9	-2.5
Forced vital capacity (FVC), Best measure	0.4	1.5	2.8	1.7	-1.0	0.7
Body fat percentage	0.0	0.1	0.3	-0.3	0.1	0.5
Leg fat percentage (right)	0.1	0.3	0.9	-1.0	0.0	0.3
Arm fat-free mass (right)	0.6	3.3	6.0	-2.5	-1.4	-1.4
Exposure to tobacco smoke outside home	2.9	3.9	4.6	-2.1	-1.6	-2.1
Comparative body size at age 10	0.5	1.3	3.5	0.2	-1.9	-0.7
Number of full brothers	1.5	1.9	3.2	-1.2	-1.0	-1.8
Worry too long after embarrassment	0.3	0.5	1.2	-1.1	-0.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.7	-0.8	-0.7	-1.3
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	-0.5	-0.1	-1.4
Number of children fathered	2.8	3.1	6.1	-1.7	-0.4	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.5	0.3	-0.3
Age at first live birth	1.4	2.5	5.5	0.6	2.3	1.3
Pulse wave peak to peak time	0.0	0.1	0.1	-0.2	0.1	-0.3
Health satisfaction	0.3	0.4	0.6	0.8	0.4	-0.7
Shortness of breath walking on level ground	0.1	0.2	0.4	0.1	0.7	-0.2
Qualifications: College or University degree	0.4	1.2	3.1	-0.5	1.8	0.4
Eye problems/disorders: None of the above	0.5	0.6	1.3	-0.5	-1.1	-0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.7	-0.8	-1.6	-1.0
Emphysema/chronic bronchitis	2.4	2.7	3.4	1.8	1.7	1.3
Medication for pain relief, constipation, heartburn	0.9	1.6	2.0	1.1	1.3	1.4
Neck or shoulder pain in last month	3.4	4.8	10.2	-0.8	-1.9	-3.2
Medication: Blood pressure	1.0	1.7	3.0	0.1	1.7	1.4
Angina (self-reported)	0.2	0.3	0.7	-0.4	-0.1	-0.8
Migraine (self-reported)	0.2	0.2	0.5	0.7	-0.4	0.2
Medication: Ibuprofen	0.3	0.3	0.6	0.5	-0.2	-0.8
Medication: Allopurinol	0.2	0.2	0.4	-0.4	0.3	-0.6
Medication: Omeprazole	0.2	0.2	0.4	0.4	0.7	-0.1
Medication: Seretide 50 evohaler	1.0	1.1	1.9	1.1	0.5	1.4
Mean time to correctly identify matches	0.5	1.0	2.0	-1.4	0.7	-0.7
Heart disease (mother)	0.2	0.2	0.4	0.4	-0.7	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	0.9	0.1	0.5
Whole body fat mass	0.1	0.4	0.8	-0.9	-0.6	0.1
Leg fat mass (right)	0.2	0.6	1.1	-1.1	-0.8	0.2
Arm predicted mass (right)	0.5	2.7	5.2	-2.3	-1.1	-1.2
Pulse rate, automated reading	0.8	2.6	4.8	1.6	-2.2	0.8
Alcohol intake frequency.	0.4	1.0	2.1	-0.3	-1.4	-0.9
Comparative height size at age 10	0.2	1.2	1.9	-1.4	0.8	-0.9
Number of full sisters	0.6	0.7	1.8	0.5	-1.3	-0.1
Suffer from ‘nerves’	1.1	1.8	4.3	-1.0	-0.1	-2.1
Overall health rating	0.2	0.5	0.7	0.8	-0.6	-0.8
Chest pain or discomfort	1.0	1.4	3.8	-0.5	0.3	-1.9
Had major operations	3.0	3.5	5.1	-2.3	1.8	-1.4
Age at last live birth	2.5	3.7	9.9	-0.8	3.1	0.7
Family relationship satisfaction	0.1	0.1	0.2	0.4	-0.1	-0.4
Leg pain on walking	1.0	1.2	3.5	0.1	-1.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.9	-0.4	-1.1	-1.4
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	0.1	-0.2
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	2.8	1.3	1.4	1.7
Medication: Aspirin	1.1	1.4	2.5	-1.6	-0.1	-1.3
Supplements: Vitamin C	0.7	0.9	1.1	-1.0	-1.0	-0.8
Knee pain experienced in last month	0.6	1.0	2.0	1.0	-1.4	-0.1
Hypertension (Self-reported)	0.2	0.7	1.1	-0.7	1.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.8	-0.2	1.9	-0.4
Illnesses of father: Heart disease	0.4	0.6	0.8	0.5	-0.8	-0.9
Illnesses of siblings: Diabetes	0.9	1.1	1.5	-1.2	-0.7	-1.1
Smoking status: Previous	0.4	0.5	0.9	-0.9	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.1	0.7	1.1	0.5
Whole body fat-free mass	0.6	3.3	5.7	-2.4	-1.5	-1.4
Leg fat-free mass (right)	0.3	1.9	2.5	-1.5	-1.6	-0.9
Arm fat percentage (left)	0.1	0.4	1.1	0.1	0.1	1.1
Average weekly red wine intake	2.1	3.1	4.7	1.5	2.2	1.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.2	-1.1	0.8	-0.7
Mood swings	0.3	0.6	1.2	-1.1	-0.2	-0.7
Loneliness, isolation	2.9	4.0	8.8	-1.6	-0.7	-3.0
Long-standing illness, disability or infirmity	2.1	3.3	5.5	-2.1	-0.1	-2.3
Ever had bowel cancer screening	0.4	0.4	1.1	-1.0	0.5	0.2
Diabetes diagnosed by doctor	0.6	0.9	2.0	0.8	-0.5	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	0.3	0.8	0.6
Friendships satisfaction	0.8	1.0	2.0	-1.0	-0.1	-1.4
Qualifications: nursing, teaching	0.3	0.5	1.1	-0.3	0.6	1.0
Commuting to job workplace: Walk	2.5	2.7	3.7	-1.6	1.9	-1.4
Eye problems/disorders: Cataract	0.7	0.9	1.9	-0.7	-0.5	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	2.1	-0.8	1.4	-0.6
Medication for cholesterol	0.6	0.9	1.3	1.2	0.2	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.8	4.5	5.6	-1.6	-2.3	-2.4
Back pain experienced in last month	3.4	5.0	10.6	-2.0	-0.6	-3.2
Mineral and other dietary supplements	0.2	0.2	0.6	0.0	0.8	-0.1
Breast cancer (self-reported)	1.7	2.0	3.3	-0.5	-1.6	-1.8
Asthma (self-reported)	0.2	0.3	0.6	-0.8	0.6	0.2
Osteoporosis (self-reported)	0.4	0.5	0.9	-1.0	-0.2	0.7
Osteoarthritis (self-reported)	0.6	0.8	1.5	-0.5	-1.2	-0.7
Medication: Aspirin	0.9	1.2	2.2	-1.5	0.1	-1.1
Medication: Gliclazide	1.9	2.1	4.2	1.2	0.8	2.0
Illnesses of father: None of the above (group 1)	0.0	0.1	0.1	-0.4	0.2	0.1
Smoking status: Current	0.0	0.0	0.1	-0.1	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	6.6	2.6	-0.7	1.9
Whole body water mass	0.7	3.8	6.5	-2.5	-1.6	-1.6
Leg predicted mass (right)	0.3	1.8	2.6	-1.4	-1.6	-0.9
Arm fat mass (left)	0.1	0.4	0.5	-0.7	-0.7	0.5
Number of self-reported non-cancer illnesses	1.9	3.3	4.0	-2.0	1.4	-2.0
Average weekly champagne plus white wine intake	3.0	4.1	8.8	0.5	3.0	1.8
Miserableness	0.3	0.5	0.9	-0.6	0.3	-1.0
Guilty feelings	0.7	1.1	2.2	-0.1	-1.5	-1.0
Wears glasses or contact lenses	0.1	0.1	0.1	-0.4	0.2	-0.2
Ever taken oral contraceptive pill	0.6	0.7	2.0	-0.4	1.4	-0.2
Hearing aid user	0.2	0.3	0.4	-0.5	-0.6	-0.3
Mother’s age at death	0.2	0.3	0.5	0.7	0.4	0.5
Financial situation satisfaction	0.3	0.4	1.1	0.0	-1.1	-0.3
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.7	1.2	-1.6	-0.2
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.3	-0.7	0.6
Eye problems/disorders: Glaucoma	1.2	1.4	2.1	-1.0	-1.1	-1.4
Medication: Blood pressure	1.2	2.3	3.9	-2.0	-1.2	-1.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.3	-0.2	-1.1	-0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.2	0.6	-0.8	1.1
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.1	-0.3	0.0
Medication: Bendroflumethiazide	0.3	0.4	1.2	-0.2	-0.1	1.1
Medication: Paracetamol	0.6	1.0	2.3	0.3	-1.5	0.7
Medication: Lisinopril	0.3	0.4	0.7	-0.6	-0.8	-0.4
Medication: Atorvastatin	0.6	0.7	1.1	0.9	1.0	0.5
Illnesses of father: High blood pressure	2.5	3.1	4.5	-1.4	-1.6	-2.1
Alcohol drinker status: Never	0.5	0.6	1.0	0.7	-1.0	-0.5
Ever smoked	0.5	0.8	2.1	-0.6	1.5	-0.2
Basal metabolic rate	0.5	2.9	4.8	-2.2	-1.5	-1.2
Leg fat percentage (left)	0.1	0.4	1.1	-1.0	0.2	0.1
Arm fat-free mass (left)	0.9	4.5	7.7	-2.8	-1.6	-1.8
Number of operations (self-reported)	0.0	0.0	0.1	-0.1	0.2	-0.0
Average weekly beer plus cider intake	0.1	0.2	0.6	-0.8	-0.2	-0.0
Irritability	0.2	0.3	0.4	-0.7	-0.6	-0.3
Risk taking	0.8	1.2	3.2	-0.1	-1.8	-0.6
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.5	-1.4	1.9	-0.8
Fractured/broken bones in last 5 years	0.3	0.4	0.9	1.0	-0.6	0.0
Age started oral contraceptive pill	0.4	0.5	1.0	-0.6	-1.0	-0.2
Diastolic blood pressure, automated reading	0.3	0.8	2.2	-1.5	-0.1	-0.5
Ever depressed for a whole week	0.6	0.8	1.9	-0.2	-0.7	-1.4
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.1	-0.3	-0.2
Commuting to job workplace: Cycle	1.1	1.3	2.3	0.9	1.5	0.8
Myopia	0.5	0.7	0.9	0.8	0.7	1.0
Vascular/heart problems diagnosed by doctor	0.6	1.6	2.8	1.4	-1.7	0.2
Cholesterol lowering medication	0.2	0.3	0.7	-0.8	0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.9	0.9	0.8	0.3
Pain experienced in last month	4.5	7.5	17.7	2.1	0.7	4.2
Supplements: Calcium	0.5	0.5	1.1	-0.7	1.1	0.0
Basal cell carcinoma (self-reported)	1.1	1.3	2.8	0.4	-1.7	1.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	-0.1	1.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.0	1.4	0.3	0.6
Heart disease (siblings)	2.8	3.4	5.1	-0.6	-2.3	-2.2
Alcohol drinker status: Previous	1.0	1.1	2.1	1.1	0.3	1.4
Pack years of smoking	0.3	0.4	0.7	0.6	-0.8	0.3
Impedance of whole body	0.2	1.1	1.7	1.3	1.2	0.2
Leg fat mass (left)	0.1	0.5	1.2	-1.1	-0.6	0.2
Arm predicted mass (left)	0.7	3.7	6.2	-2.5	-1.6	-1.5