TWAS hub - BEST3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0760	0.0260	0.00037	0.034	0.029	0.057	0.032	0.042	4.7e-05	1.6e-04	1.7e-07	7.9e-05	7.4e-06
2	TCGA	Esophageal Carcinoma	0.1490	0.0800	0.00420	0.009	0.026	0.017	NA	0.003	1.6e-01	5.1e-02	9.0e-02	NA	2.4e-01
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0821	0.0337	0.00029	0.026	0.036	0.044	NA	0.039	5.6e-04	6.4e-05	1.1e-05	NA	2.8e-05
4	TCGA	Brain Lower Grade Glioma	0.0392	0.0168	0.00051	0.030	0.020	0.014	NA	0.014	2.2e-04	2.4e-03	8.0e-03	NA	9.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Chronic bronchitis/emphysema (father)	4.4	5.1	11.0	1.8	1.2	3.3	2.2
Osteoporosis (self-reported)	4.4	5.4	9.2	2.5	3.0	2.3	0.9
Vitamin and mineral supplements	3.8	5.1	11.0	-2.2	-0.4	-2.1	-3.3
Commuting to job workplace: Public transport	3.6	4.3	7.2	2.7	2.0	1.9	1.6
Lung FEV1/FVC ratio	3.5	17.9	41.3	4.0	6.4	3.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	3.5	4.3	14.2	-1.6	-3.8	-0.4	0.5
Loud music exposure frequency	3.1	3.4	5.8	-1.7	-0.3	-2.2	-2.4
Ever depressed for a whole week	3.1	3.8	10.4	-1.4	0.0	-3.2	-1.7
Headache pain in last month	2.8	4.8	10.0	-1.5	-2.6	-3.2	-0.2
Townsend deprivation index at recruitment	2.7	3.8	7.2	2.1	2.7	1.5	1.1
Serious illness, injury or assault to yourself	2.7	3.2	9.0	1.8	3.0	0.9	-0.0
Hearing aid user	2.7	3.0	8.6	2.9	1.2	0.7	1.2
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	11.6	-0.6	1.0	-0.4	-3.4
Ovarian Cancer	2.6	3.5	7.0	2.6	2.6	-0.4	0.5
Medication: Omeprazole	2.4	2.9	10.0	-1.0	0.6	-0.3	-3.2
Ever taken oral contraceptive pill	2.4	2.6	8.1	-1.4	-2.8	0.4	0.6
Bipolar Disorder (2018)	2.3	3.7	5.3	1.7	1.3	2.3	2.2
Alcohol drinker status: Previous	2.3	2.6	5.8	1.6	2.4	1.5	0.1
Fasting Glucose	2.2	2.6	5.7	-1.7	-2.4	-1.3	0.6
Mouth/teeth dental problems: Loose teeth	2.2	2.6	6.7	1.9	0.5	0.1	2.6
Pulse wave reflection index	2.1	2.6	6.7	-1.9	-0.2	-0.1	-2.6
Ulcerative Colitis	2.0	2.9	4.5	2.1	0.5	1.9	1.8
Allergy or Eczema	2.0	5.2	10.0	-2.9	-3.2	-1.0	-1.2
Maternal smoking around birth	2.0	2.8	8.2	-2.9	-0.7	-0.7	-1.5
Ever had bowel cancer screening	2.0	2.4	4.1	1.4	2.0	0.9	-1.6
Severe depression (siblings)	1.9	2.1	3.4	1.8	1.2	1.5	1.1
High blood pressure (mother)	1.9	2.7	4.7	-1.3	-1.8	-2.2	-1.1
Number of full brothers	1.9	2.4	4.9	2.2	1.9	1.0	0.6
Knee pain experienced in last month	1.9	3.0	6.2	-1.8	-2.5	-0.8	-1.4
Friendships satisfaction	1.9	2.3	3.3	1.3	1.8	-1.6	-1.3
Alcohol drinker status: Never	1.9	2.2	4.6	1.9	2.1	0.5	0.6
Heart attack	1.8	2.3	4.2	-1.8	0.0	-2.0	-1.2
Commuting to job workplace: Walk	1.8	2.0	2.5	1.6	1.5	0.9	1.6
Hayfever, allergic rhinitis or eczema	1.7	3.6	7.3	-2.4	-2.7	-0.9	-0.8
Emphysema/chronic bronchitis	1.7	1.9	3.0	1.7	1.1	1.5	1.1
Osteoarthritis (self-reported)	1.7	2.1	7.2	-1.1	-2.7	0.2	0.4
Angina	1.6	2.1	7.3	-0.3	-0.2	-0.9	-2.7
Supplements: Glucosamine	1.6	2.1	4.2	-0.9	-2.0	-0.0	1.9
Angina (self-reported)	1.6	2.1	7.8	-0.2	0.1	-0.8	-2.8
Multivitamins +/- minerals	1.5	1.9	6.3	0.5	-0.7	0.7	2.5
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.3	-0.9	-1.1	-2.1	-0.9
Number of live births	1.5	2.1	4.2	1.3	2.0	1.1	1.1
Back pain experienced in last month	1.5	2.2	2.8	-1.3	-1.4	-1.7	-1.5
Alzheimer’s Disease (in father)	1.4	1.5	3.2	0.6	1.8	1.2	-1.0
Bipolar Disorder (2011)	1.4	1.4	3.0	1.4	0.2	0.6	1.7
Triglycerides	1.4	2.2	5.0	0.2	-2.0	0.1	2.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	5.5	0.9	2.3	-0.1	-0.7
Chronic bronchitis/emphysema (mother)	1.4	1.7	4.1	2.0	1.1	1.1	0.6
Pain type(s) experienced in last month: Hip pain	1.4	1.7	2.1	-1.4	-1.5	0.9	-1.4
Happiness	1.3	1.6	3.0	1.7	1.3	-1.3	0.5
Mouth/teeth dental problems: Dentures	1.3	2.2	3.6	0.1	-1.7	1.5	1.9
Blood clot in the leg (DVT)	1.3	1.7	5.6	-0.1	1.0	-0.4	-2.4
Supplements: Vitamin C	1.3	1.5	3.2	1.8	-0.3	1.7	0.1
Heart attack/myocardial infarction (self-reported)	1.3	1.6	3.4	-1.4	0.0	-1.8	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	5.4	-0.0	1.0	-0.5	-2.3
High blood pressure (siblings)	1.2	1.8	4.3	-1.1	-2.1	-1.2	-0.5
Number of full sisters	1.2	1.4	2.7	1.6	1.6	0.2	0.5
Risk taking	1.2	1.7	2.6	-1.6	-1.1	1.0	1.4
Medication: Atenolol	1.1	1.4	2.3	-1.1	-1.5	-0.5	-1.4
Hearing difficulty/problems with background noise	1.1	1.7	2.4	1.6	1.2	1.2	1.4
Had menopause	1.1	1.4	2.4	1.5	1.6	-0.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.3	1.2	0.9	0.4	1.8
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.2	1.5	1.8	1.2	0.5
Medication: Ventolin 100micrograms inhaler	1.1	1.5	4.5	-0.8	-2.1	-0.9	0.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.4	-1.8	-1.7	0.4	-0.5
Medication for cholesterol	1.1	1.7	6.2	-0.5	0.0	-2.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	5.5	0.6	2.3	1.5	-1.0
Eye problems/disorders: Glaucoma	1.1	1.3	3.4	-1.9	-0.0	0.4	-1.3
Waist Hip Ratio (WHR)	1.0	4.6	8.8	2.5	3.0	1.6	0.9
Diabetes (father)	1.0	1.2	3.5	1.9	0.9	0.5	0.5
Noisy workplace	1.0	1.2	2.2	-0.5	-1.5	-1.0	1.1
Illnesses of mother	1.0	1.3	4.7	-0.3	0.0	-2.2	-0.6
Heart disease (mother)	1.0	1.2	4.2	0.1	0.8	2.0	-0.3
Qualifications: nursing, teaching	1.0	1.5	3.8	-1.1	-1.9	0.8	0.7
Supplements: Calcium	1.0	1.1	2.2	1.0	1.5	-1.1	0.1
Schizophrenia vs Biploar Disorder	0.9	1.1	3.1	-1.0	-0.5	-1.8	-0.3
Coronary Artery Disease (CAD)	0.9	1.1	4.0	-0.3	-0.5	2.0	-0.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.9	1.0	-0.7	-0.6	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.2	-0.9	-1.5	-1.2	0.6
Alcohol usually taken with meals	0.9	1.5	3.0	0.1	-0.3	1.7	1.7
Mouth/teeth dental problems	0.9	1.3	3.7	0.1	1.3	-0.3	-1.9
Length of working week for main job	0.9	0.9	1.8	0.8	0.3	1.1	1.4
Medication: Paracetamol	0.9	1.6	2.7	-1.6	-1.6	-0.9	0.5
Number of children fathered	0.9	1.1	2.5	-1.6	-0.9	-1.0	0.0
Migraine (self-reported)	0.9	1.1	1.9	-0.6	-1.4	-1.3	0.5
Medication: Ibuprofen	0.9	1.1	2.4	0.9	0.7	0.7	1.6
Mean time to correctly identify matches	0.9	1.7	2.9	1.1	1.7	1.6	0.2
Eye problems/disorders: Cataract	0.9	1.1	2.4	1.6	0.3	1.3	0.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.6	1.6	1.2	-0.4	-0.2
Depression (Nagel 2018)	0.8	1.2	2.3	-0.0	-1.2	-0.8	1.5
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.9	-1.3	-0.3	2.2	-1.0
Mean Putamen Volume	0.8	0.9	1.5	-1.2	-1.2	0.3	-0.8
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.6	0.1	-1.2	0.8	1.3
Hearing difficulty/problems: Yes	0.8	1.2	2.6	1.6	0.1	0.8	1.3
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.0	1.3	1.4	-0.5	-0.5
Impedance of leg (right)	0.8	3.9	4.6	1.6	2.0	2.1	2.1
Qualifications: CSEs or equivalent	0.8	1.0	2.1	-0.0	-1.1	-0.9	-1.5
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.1	1.4	0.7	1.0	0.7
Financial difficulties in last 2 years	0.8	1.1	1.7	-1.1	-0.7	-1.3	-1.1
Hair/balding pattern: Pattern 4	0.8	1.9	3.5	-1.4	-1.4	-1.9	-0.3
Peak expiratory flow (PEF)	0.8	1.9	5.4	0.3	2.3	0.7	-1.2
Wheeze or whistling in the chest in last year	0.8	1.4	2.8	-1.4	-1.7	-0.8	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.6	0.6	0.9	1.0	1.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.8	-1.3	-1.0	-0.5	-0.7
Number of self-reported non-cancer illnesses	0.8	1.3	4.1	0.9	0.4	2.0	-0.4
Average weekly champagne plus white wine intake	0.8	1.1	2.5	-0.4	-1.6	-0.2	1.4
Medication: Blood pressure	0.8	1.5	3.7	0.7	-1.3	1.9	0.1
Pack years of smoking	0.8	1.2	3.1	0.9	0.9	1.8	0.2
Bipolar Disorder or Schizophrenia	0.7	1.8	4.5	0.5	0.5	1.4	2.1
Medication: Co-codamol	0.7	0.8	1.6	0.6	-1.3	-0.5	0.9
Diabetes (mother)	0.7	0.9	1.7	-0.9	-1.3	-0.6	-0.9
Pack years adult smoking proportion	0.7	1.0	2.3	0.7	1.1	1.5	-0.1
Relative age voice broke	0.7	1.1	2.6	0.1	0.5	-1.6	-1.3
Hair/balding pattern: Pattern 2	0.7	0.8	1.2	-1.1	-0.2	1.0	-1.1
Forced vital capacity (FVC)	0.7	2.6	4.5	-1.8	-0.3	-1.6	-2.1
Allergy	0.7	1.6	2.2	1.5	1.4	1.0	1.0
Diabetes (self-reported)	0.7	1.0	2.6	-0.1	-1.6	0.0	1.2
Depression (self-reported)	0.7	0.8	1.6	1.2	1.3	0.3	0.3
Birth weight of first child	0.7	1.3	3.2	0.6	1.8	-1.0	-0.9
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.5	1.6	1.1	1.2	0.7
Medication: Amlodipine	0.7	0.9	2.1	-1.2	-1.5	-0.1	-0.1
Medication: Blood pressure	0.7	1.3	2.6	-1.2	-1.6	-0.9	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.5	-1.0	0.7	-0.2	-1.2
Illnesses of father: None of the above (group 1)	0.7	0.8	1.9	-0.8	0.0	-1.4	-0.9
Medication: Bendroflumethiazide	0.7	1.1	2.4	-1.0	-0.8	1.6	-0.5
Unable to work because of sickness or disability	0.7	0.9	3.1	-0.3	0.5	1.8	-0.1
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.2	-1.8	-1.3	0.9	-1.1
Worry (Nagel 2018)	0.6	1.2	4.2	0.5	0.6	0.5	2.0
Body Mass Index (BMI) (2010)	0.6	0.9	2.9	-0.3	-1.7	-0.0	0.7
Lupus	0.6	0.9	1.4	1.2	1.1	-0.4	-0.9
Primary Biliary Cirrhosis	0.6	0.8	1.8	-0.5	-1.3	-0.6	-0.9
Rheumatoid Arthritis	0.6	0.9	1.4	-0.6	-0.7	-1.2	-1.1
Ever had hysterectomy (womb removed)	0.6	0.7	1.6	0.3	0.0	1.1	-1.3
Systolic blood pressure, automated reading	0.6	1.7	4.0	-1.2	-2.0	-0.1	-1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	0.8	0.5	0.5	-1.1
Impedance of leg (left)	0.6	2.7	4.6	1.2	2.2	1.7	1.3
Nervous feelings	0.6	1.1	2.8	1.1	0.4	0.4	1.7
Pain all over the body in last month	0.6	0.6	2.0	-0.5	-0.4	1.4	-0.1
Alcohol intake versus 10 years previously	0.6	0.9	2.9	1.7	0.5	0.5	0.3
Leg fat percentage (right)	0.6	2.2	3.9	2.0	0.9	1.9	0.6
Health satisfaction	0.6	0.8	1.1	1.0	0.4	-0.8	1.1
Shortness of breath walking on level ground	0.6	0.7	1.8	0.6	-0.3	-0.6	1.4
Pulse rate, automated reading	0.6	2.0	3.3	1.8	0.9	0.7	1.8
Alcohol intake frequency.	0.6	1.5	5.3	2.3	0.7	0.4	0.1
Family relationship satisfaction	0.6	0.8	1.9	1.4	0.8	-0.7	-0.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.7	0.6	-1.3	0.2	0.9
Medication: Aspirin	0.6	0.8	2.5	0.0	-0.2	-0.9	-1.6
Medication: Aspirin	0.6	0.7	2.0	0.4	0.3	-0.9	-1.4
Medication: Atorvastatin	0.6	0.8	1.5	-0.4	0.3	1.1	-1.2
Fractured/broken bones in last 5 years	0.6	0.7	2.6	1.6	0.6	-0.1	-0.0
Myopia	0.6	0.9	1.6	-0.8	-0.0	-1.1	-1.3
Cholesterol lowering medication	0.6	0.9	2.8	0.8	0.3	1.7	0.1
Pain experienced in last month	0.6	1.0	2.9	0.6	1.7	0.6	-0.7
Ulcerative Colitis (UC)	0.5	1.0	1.7	1.1	-0.3	1.1	1.3
Major Depression (MDD)	0.5	0.6	1.0	-0.0	0.8	1.0	-0.9
Neuroticism (2016)	0.5	0.7	1.7	0.4	0.4	-1.3	0.9
Blood Eosinophil Count	0.5	3.8	10.0	-3.2	-2.3	-0.0	-0.3
Blood Red Count	0.5	4.9	10.8	1.6	3.3	0.3	-2.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.7	0.4	-0.8	-0.2	1.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	-0.0	-0.8	-1.4	0.2
Number of incorrect matches in round	0.5	0.8	1.9	-1.0	0.4	0.1	-1.4
Had other major operations	0.5	0.6	1.3	-0.7	-0.3	0.8	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.5	-0.7	1.6	-0.7	-0.9
Qualifications: None of the above	0.5	1.1	3.5	0.8	1.9	0.3	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.6	0.3	0.5	1.3	-0.9
Illnesses of siblings	0.5	0.7	1.9	0.6	1.4	0.0	-0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.5	-0.7	1.6	0.1	-2.1
Medication: Cholesterol lowering	0.5	0.7	1.5	-0.8	-0.1	-1.2	-0.8
Prospective memory result	0.5	0.6	1.9	-0.2	-0.4	-0.7	1.4
Breastfed as a baby	0.5	0.6	1.1	-0.5	0.7	0.6	-1.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.8	0.4	0.5	-1.3	0.5
Birth weight	0.5	1.0	2.8	0.9	1.7	0.7	-0.4
Eye problems/disorders: None of the above	0.5	0.6	1.4	-0.9	-0.5	-1.2	0.0
Illnesses of father: Heart disease	0.5	0.7	1.3	0.3	-1.2	-0.9	0.6
Leg fat-free mass (right)	0.5	2.6	4.7	-0.7	-2.1	-2.2	-0.9
Mood swings	0.5	0.9	3.0	0.5	-0.3	-0.6	1.7
Loneliness, isolation	0.5	0.7	1.4	1.1	0.2	-0.1	1.2
Medication: Gliclazide	0.5	0.6	1.9	-1.4	-0.1	0.2	0.6
Leg predicted mass (right)	0.5	2.6	4.5	-0.7	-2.1	-2.1	-0.9
Illnesses of father: High blood pressure	0.5	0.7	1.7	-0.0	-0.7	-1.3	-0.6
Average weekly beer plus cider intake	0.5	0.7	2.0	-0.7	-1.4	-0.2	0.5
Irritability	0.5	0.8	2.4	-0.4	-0.9	-1.5	0.0
Neuroticism (Nagel 2018)	0.4	0.8	2.5	0.8	0.2	-0.2	1.6
Alzheimer’s Disease (including proxy)	0.4	0.6	1.3	0.0	1.1	1.0	-0.4
Heel T-Score	0.4	3.3	9.0	-0.9	3.0	1.2	-1.4
Height	0.4	7.5	22.8	0.1	-2.6	-4.8	-0.5
Systolic Blood Pressure	0.4	2.0	3.6	-1.7	-1.2	-0.3	-1.9
Lung FVC	0.4	2.0	3.5	-0.5	1.9	1.4	-1.5
Neuroticism	0.4	0.9	2.0	-0.2	-0.4	-1.4	1.2
Supplements: Zinc	0.4	0.4	0.7	0.8	0.4	0.5	0.8
Leg fat-free mass (left)	0.4	2.1	4.3	-0.3	-2.1	-2.0	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	0.6	0.5	0.7	1.0
High blood pressure	0.4	1.0	2.1	0.5	-1.4	1.4	0.0
Stomach or abdominal pain in last month	0.4	0.5	1.6	-0.0	0.1	0.6	1.2
Medication: Levothyroxine sodium	0.4	0.8	2.4	1.6	0.6	0.5	0.2
Leg predicted mass (left)	0.4	2.1	4.2	-0.3	-2.1	-2.0	-0.5
Worrier / anxious feelings	0.4	0.7	1.2	1.1	0.0	0.6	1.1
Falls in the last year	0.4	0.5	0.7	0.7	0.7	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.9	0.1	2.0	0.3	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.8	-0.3	-0.5	-0.3	1.4
Exposure to tobacco smoke outside home	0.4	0.5	1.9	0.2	-1.4	0.1	0.2
Worry too long after embarrassment	0.4	0.6	2.3	0.4	-0.1	-1.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	0.4	0.8	0.2	1.1
Age at first live birth	0.4	0.7	2.5	0.3	-0.2	0.3	1.6
Medication: Allopurinol	0.4	0.5	1.1	-0.1	0.6	1.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	-0.2	-0.9	-0.4	-0.9
Chest pain or discomfort	0.4	0.5	0.9	0.1	1.0	0.9	-0.6
Leg pain on walking	0.4	0.5	0.9	-1.0	-0.3	-0.7	0.8
Hypertension (Self-reported)	0.4	1.2	3.7	-0.0	-1.9	1.1	-0.1
Average weekly red wine intake	0.4	0.6	1.4	-0.4	0.1	1.0	1.2
Diabetes diagnosed by doctor	0.4	0.7	1.4	-0.4	-1.2	-0.5	1.0
Mineral and other dietary supplements	0.4	0.5	1.6	0.0	0.6	0.2	-1.3
Smoking status: Current	0.4	0.6	1.8	-0.4	-0.7	-1.3	0.2
Miserableness	0.4	0.6	2.1	-0.1	-0.1	-0.7	-1.4
Wears glasses or contact lenses	0.4	0.5	1.3	-0.2	-1.1	-0.6	0.6
Medication: Paracetamol	0.4	0.7	1.4	-1.0	-1.2	-0.6	0.3
Ever smoked	0.4	0.7	2.3	-0.6	-1.5	-0.2	-0.1
Leg fat percentage (left)	0.4	1.4	2.5	1.5	0.9	1.6	-0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	0.7	-0.5	-0.5	1.0
Impedance of whole body	0.4	1.9	3.7	1.0	1.4	1.1	1.9
Depressed Affect (Nagel 2018)	0.3	0.7	2.1	0.5	-0.6	-0.3	1.5
HbA1C	0.3	0.3	0.5	0.7	0.4	0.4	0.7
Hypothyroidism (self reported)	0.3	0.6	1.3	1.1	0.7	0.7	0.3
Hand grip strength (left)	0.3	0.9	1.4	-0.5	1.0	-0.9	-1.2
Sensitivity / hurt feelings	0.3	0.5	1.1	-0.7	-1.1	-0.6	0.1
Average weekly fortified wine intake	0.3	0.4	0.8	-0.8	0.9	-0.1	-0.3
Taking other prescription medications	0.3	0.4	1.0	0.6	0.5	1.0	-0.1
Age when periods started (menarche)	0.3	0.8	1.7	0.8	-1.3	-0.4	0.8
Sitting height	0.3	2.0	3.6	1.8	-0.4	-0.9	1.9
Past tobacco smoking	0.3	0.5	1.8	-0.2	1.3	0.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	-0.4	1.0	-0.2	-0.7
Neuroticism score	0.3	0.6	1.7	-0.1	-0.7	-1.3	0.4
Time employed in main current job	0.3	0.3	0.5	0.6	0.6	0.7	0.3
Father’s age at death	0.3	0.4	1.0	-0.0	-0.1	0.7	1.0
Pulse rate	0.3	0.5	0.8	0.7	0.8	0.0	0.9
Medication: Lansoprazole	0.3	0.3	1.0	-0.1	-0.4	-0.2	-1.0
Lung cancer (father)	0.3	0.3	0.9	-0.9	-0.2	0.2	-0.7
Tense / ‘highly strung’	0.3	0.5	1.2	-0.7	-0.3	-1.1	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.5	-0.1	-1.2	0.5	0.3
Glaucoma (self-reported)	0.3	0.4	0.6	-0.6	0.2	0.8	-0.7
Gout (self-reported)	0.3	0.4	0.7	0.6	0.6	0.8	-0.2
Comparative body size at age 10	0.3	0.7	2.5	1.6	0.5	-0.0	-0.3
Medication: Seretide 50 evohaler	0.3	0.4	1.1	0.2	-0.3	0.5	1.0
Comparative height size at age 10	0.3	1.8	6.6	0.2	-0.3	-2.6	0.6
Had major operations	0.3	0.4	0.9	-0.1	-0.0	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.7	0.1	-1.3	0.4	0.9
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	-0.3	0.5	-0.4	-0.9
Whole body water mass	0.3	1.6	3.1	-0.2	-1.6	-1.8	-0.9
Financial situation satisfaction	0.3	0.4	1.1	-0.1	0.1	-1.0	-0.7
High cholesterol (Self-reported)	0.3	0.5	0.8	0.5	0.9	0.5	-0.9
Diastolic blood pressure, automated reading	0.3	1.1	2.0	0.1	-1.0	1.4	-1.1
Heart disease (siblings)	0.3	0.3	1.1	-0.3	-0.3	1.0	0.3
Schizophrenia (2018)	0.2	0.5	0.9	-0.8	-0.5	-0.0	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.8	-0.1	0.2	0.2
Crohns Disease (2017)	0.2	0.4	0.9	1.0	-0.6	-0.4	-0.1
Irritable Bowel Disease (IBD)	0.2	0.6	0.9	1.0	-0.7	0.4	0.8
Reaction Time	0.2	0.4	1.0	0.4	1.0	0.5	0.3
Age at First Birth	0.2	0.2	0.8	-0.9	-0.0	0.0	-0.4
Crohns Disease (2012)	0.2	0.3	0.7	0.7	-0.8	-0.1	0.4
HDL Cholesterol	0.2	0.3	0.5	0.0	0.6	0.7	0.6
Schizophrenia (2014)	0.2	0.5	1.0	-1.0	-0.8	-0.6	0.4
BMI	0.2	0.9	1.5	0.6	-1.2	1.2	0.4
Smoking Status	0.2	0.6	1.5	-0.2	-1.2	-0.6	0.6
Cardiovascular Disease	0.2	0.7	1.5	-0.1	-1.2	1.1	0.3
Respiratory disease	0.2	0.5	0.9	0.9	1.0	-0.6	0.2
Tanning	0.2	1.9	3.8	-0.1	1.8	2.0	0.5
Number of treatments/medications taken	0.2	0.4	0.8	0.2	-0.7	0.9	0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.6	0.3	0.3	0.8
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.1	0.7	-0.6	0.3
Trunk fat percentage	0.2	0.6	1.4	1.2	0.3	0.8	0.6
Current tobacco smoking	0.2	0.3	0.9	0.1	-0.4	-0.9	0.5
Fed-up feelings	0.2	0.3	0.7	0.8	0.3	-0.7	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.3	-0.6	1.1	0.2	-0.3
Waist circumference	0.2	0.7	2.1	1.5	0.8	0.3	-0.2
Medication: Ramipril	0.2	0.3	0.7	-0.4	-0.3	-0.5	-0.8
Fluid intelligence score	0.2	0.4	0.7	-0.8	-0.4	0.7	-0.6
Impedance of arm (right)	0.2	0.9	3.5	0.1	0.3	0.3	1.9
Trunk fat-free mass	0.2	1.1	2.3	0.1	-1.3	-1.5	-0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.9	-0.0	-0.1	0.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.3	-0.8	-0.2	0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	-0.3	-0.1	0.8	0.2
Impedance of arm (left)	0.2	1.1	3.9	0.2	0.3	0.6	2.0
Trunk predicted mass	0.2	1.1	2.2	0.1	-1.3	-1.5	-0.8
Standing height	0.2	2.0	6.2	0.5	-1.1	-2.5	0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	1.1	-0.8	0.3	-0.8	-1.0
Body fat percentage	0.2	0.9	2.0	1.4	0.4	1.1	0.4
Arm fat-free mass (right)	0.2	0.9	1.8	0.5	-0.8	-1.3	-1.0
Pulse wave peak to peak time	0.2	0.3	1.0	0.3	-0.1	-1.0	-0.1
Qualifications: College or University degree	0.2	0.7	1.4	0.8	0.8	1.2	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	0.0	1.0	0.3	-0.6
Leg fat mass (right)	0.2	0.7	2.1	1.5	-0.1	0.9	0.3
Arm predicted mass (right)	0.2	0.8	1.4	0.2	-0.9	-1.1	-1.2
Age at last live birth	0.2	0.2	0.7	-0.8	-0.1	-0.4	0.3
Smoking status: Previous	0.2	0.3	0.9	0.4	-0.9	0.1	0.5
Whole body fat-free mass	0.2	1.4	2.7	-0.1	-1.5	-1.6	-0.8
Breast cancer (self-reported)	0.2	0.3	0.6	0.8	-0.8	-0.1	0.1
Mother’s age at death	0.2	0.3	0.6	-0.4	-0.2	-0.4	0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	0.0	0.3	0.7	0.8
Basal metabolic rate	0.2	1.2	2.3	0.1	-1.4	-1.5	-0.8
Number of operations (self-reported)	0.2	0.3	0.8	-0.2	-0.1	0.5	-0.9
Age started oral contraceptive pill	0.2	0.3	0.9	-0.1	0.3	0.2	-1.0
Commuting to job workplace: Cycle	0.2	0.3	0.4	-0.6	-0.6	-0.4	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.1	-0.4	1.0	-0.9	0.4
Arm predicted mass (left)	0.2	0.8	1.4	0.7	-0.6	-1.2	-1.0
LDL Cholesterol	0.1	0.2	0.6	0.3	0.3	0.8	-0.0
Blood Platelet Count	0.1	0.7	2.4	-1.5	-0.4	0.4	0.2
Blood White Count	0.1	0.8	1.5	1.2	-0.2	-1.1	0.7
Chronotype (morning person)	0.1	0.2	0.4	-0.7	0.6	0.1	0.3
Average weekly spirits intake	0.1	0.1	0.2	-0.3	-0.2	-0.4	-0.4
Medication: Metformin	0.1	0.1	0.3	0.3	-0.2	-0.4	0.6
Body mass index (BMI)	0.1	0.3	0.4	0.5	-0.5	0.5	-0.6
Trunk fat mass	0.1	0.3	1.0	1.0	-0.2	0.2	0.3
Medication: Simvastatin	0.1	0.2	0.6	0.1	-0.2	-0.8	0.1
Weight	0.1	0.6	1.1	0.6	-1.1	-0.8	-0.5
Arm fat percentage (right)	0.1	0.4	0.9	0.9	-0.1	1.0	0.2
Hip circumference	0.1	0.3	0.7	0.8	-0.7	-0.3	0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.4	-0.4	-0.7	-0.0
Asthma	0.1	0.1	0.4	0.2	0.1	-0.3	0.6
Arm fat mass (right)	0.1	0.3	0.8	0.9	-0.4	0.5	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.0	0.5	0.4	-0.1
Neck or shoulder pain in last month	0.1	0.2	0.3	0.5	0.6	0.3	0.2
Whole body fat mass	0.1	0.4	1.5	1.2	-0.2	0.4	0.2
Overall health rating	0.1	0.2	0.4	0.3	-0.6	-0.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	-0.1	-0.2	-0.6	-0.4
Illnesses of siblings: Diabetes	0.1	0.2	0.5	-0.0	-0.2	0.4	0.7
Arm fat percentage (left)	0.1	0.6	1.5	0.8	-0.3	1.2	0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.1	0.1	0.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	0.2	-0.6	0.3	0.4
Asthma (self-reported)	0.1	0.2	0.4	0.3	0.4	-0.2	0.7
Arm fat mass (left)	0.1	0.4	0.6	0.8	-0.6	0.7	0.1
Guilty feelings	0.1	0.2	0.7	-0.2	-0.1	-0.8	-0.3
Medication: Lisinopril	0.1	0.1	0.3	-0.2	-0.2	0.6	-0.2
Arm fat-free mass (left)	0.1	0.6	0.8	0.3	-0.8	-0.9	-0.8
Leg fat mass (left)	0.1	0.4	1.3	1.1	-0.2	0.5	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.2	0.6	-0.7	-0.4	0.4	-0.2
Relative age of first facial hair	0.0	0.1	0.2	0.2	0.3	0.0	-0.4
Hand grip strength (right)	0.0	0.0	0.1	-0.2	0.1	-0.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.2	-0.1	0.5	-0.0	-0.1
Suffer from ‘nerves’	0.0	0.0	0.1	-0.1	0.3	0.2	0.2
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	-0.0	0.0	-0.4	-0.1

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