Hub : Genes

BLCAP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.1970	0.0810	5.4e-03	-0.006	NA	0.020	NA	-0.008	6.1e-01	NA	6.6e-02	NA	8.8e-01
2	GTEx	Esophagus Mucosa	0.0740	0.0300	3.4e-03	0.077	NA	0.054	NA	0.070	7.8e-06	NA	1.7e-04	NA	2.0e-05
3	NTR	Blood	0.0305	0.0104	1.3e-05	0.027	0.022	0.024	0.025	0.025	3.8e-09	9.8e-08	2.1e-08	1.2e-08	1.2e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	1.1	-0.8	-0.9	1.1
Bipolar Disorder or Schizophrenia	0.8	1.9	2.5	-1.6	-1.2	1.3
Depressed Affect (Nagel 2018)	0.9	2.0	3.1	-1.0	-1.3	1.8
Depression (Nagel 2018)	0.6	0.8	2.3	-1.5	0.4	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	0.9	-0.1	0.4
Neuroticism (Nagel 2018)	2.2	5.2	7.8	-1.2	-2.5	2.8
Schizophrenia (2018)	0.5	1.1	1.8	-1.3	-0.8	0.8
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	-0.7	0.1	0.3
Worry (Nagel 2018)	4.1	8.7	13.1	-0.0	-3.6	3.6
Alzheimer’s Disease (in mother)	2.4	2.9	6.8	-2.6	-1.1	0.7
Alzheimer’s Disease (in father)	0.7	0.7	1.2	0.4	-0.9	1.1
Alzheimer’s Disease (including proxy)	0.7	1.0	1.3	-1.1	-0.9	1.0
Crohns Disease (2017)	0.2	0.5	0.8	-0.3	-0.7	0.9
Irritable Bowel Disease (IBD)	0.4	0.8	1.8	1.4	0.6	-0.5
Ulcerative Colitis (UC)	1.8	3.3	4.9	2.2	1.6	-1.6
Major Depression (MDD)	1.8	2.2	4.5	-2.1	-1.2	0.7
Reaction Time	0.2	0.3	0.9	0.9	0.1	0.3
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	0.2	0.2	-0.2
Breast Cancer	0.3	0.8	1.3	-1.1	-0.8	0.7
Ovarian Cancer	2.2	2.9	8.2	2.9	-0.4	0.5
Prostate Cancer	0.2	0.3	0.4	0.3	-0.6	0.6
Age at First Birth	0.5	0.7	1.0	0.6	0.9	-1.0
Bipolar Disorder (2011)	0.2	0.2	0.3	-0.6	0.1	-0.4
Body Mass Index (BMI) (2010)	0.9	1.2	2.1	-0.0	-1.4	1.2
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.8	0.2	-0.3
Crohns Disease (2012)	0.1	0.2	0.3	-0.6	-0.4	0.2
Mean Putamen Volume	0.6	0.7	0.8	0.7	-0.9	0.8
Fasting Glucose	2.1	2.5	2.7	1.6	1.5	-1.6
HbA1C	0.7	0.7	2.1	-1.4	-0.3	0.1
HDL Cholesterol	0.6	0.9	1.1	-0.8	1.1	-1.0
LDL Cholesterol	0.5	0.8	2.4	1.5	-0.4	0.1
Lupus	0.3	0.5	0.6	0.6	0.7	-0.7
Neuroticism (2016)	0.4	0.6	1.2	-1.1	-0.5	0.5
Primary Biliary Cirrhosis	0.8	1.1	2.1	-1.4	0.7	-0.9
Rheumatoid Arthritis	2.8	3.8	5.7	0.7	2.3	-2.4
Schizophrenia (2014)	0.7	1.6	1.9	-1.1	-1.4	1.4
Triglycerides	0.0	0.0	0.0	0.1	0.1	-0.1
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.5	0.9	-1.6	1.3
Ulcerative Colitis	0.3	0.4	0.8	0.9	0.4	-0.5
Blood Eosinophil Count	0.3	2.5	3.5	-0.8	-1.8	1.9
Blood Platelet Count	0.0	0.5	0.7	0.5	-0.7	0.8
Blood Red Count	0.1	1.0	1.1	-1.0	-0.9	1.1
Blood White Count	0.4	3.1	4.8	-0.6	-2.2	2.0
Heel T-Score	0.1	1.1	3.2	1.8	0.1	-0.0
BMI	0.6	3.4	5.2	-0.4	-2.3	2.2
Height	1.3	25.8	46.2	-6.8	4.0	-3.9
Waist Hip Ratio (WHR)	0.5	2.1	2.7	1.3	-1.4	1.6
Systolic Blood Pressure	0.0	0.2	0.3	0.3	-0.6	0.4
Smoking Status	5.5	13.2	20.2	-1.5	-4.5	4.1
Allergy or Eczema	0.2	0.5	0.8	0.5	-0.9	0.7
Cardiovascular Disease	0.0	0.1	0.1	-0.3	-0.3	-0.1
Hypothyroidism (self reported)	0.1	0.3	0.4	0.6	0.6	-0.3
Respiratory disease	1.0	2.2	6.6	2.6	-0.2	0.1
Type 2 Diabetes (T2D) (2018)	1.4	2.6	4.2	-0.1	-2.1	1.9
Lung FEV1/FVC ratio	0.3	1.4	1.9	-1.2	-0.9	1.4
Lung FVC	1.2	6.2	7.2	-2.0	-2.7	2.7
Neuroticism	2.0	4.8	6.2	-1.7	-2.4	2.5
Chronotype (morning person)	0.7	1.6	2.7	1.6	-1.0	1.0
Hair Pigment	0.0	0.5	0.7	-0.9	-0.5	0.8
Tanning	0.4	5.4	8.8	3.0	-2.1	1.7
Hand grip strength (left)	0.5	1.2	3.2	-1.8	0.4	-0.5
Number of treatments/medications taken	0.2	0.3	0.6	-0.4	-0.6	0.8
Average weekly spirits intake	1.4	1.7	1.8	1.2	-1.3	1.3
Sensitivity / hurt feelings	2.1	3.6	4.5	-1.6	-2.1	2.0
Frequency of depressed mood in last 2 weeks	2.1	2.9	8.7	-3.0	0.0	0.2
Hearing difficulty/problems: Yes	7.4	11.3	15.8	1.9	-3.8	4.0
Relative age of first facial hair	0.4	0.8	2.2	-1.5	-0.3	0.3
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	6.1	-2.5	-0.6	0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.4	-0.5	-1.2	0.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	0.2	-0.9	1.0
Systolic blood pressure, automated reading	0.3	0.8	1.1	-0.7	0.9	-1.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.2	-0.4	0.5
Angina	0.1	0.2	0.3	-0.3	0.4	-0.5
Medication for hormone replacement therapy	0.3	0.4	0.5	-0.6	-0.7	0.6
Vitamin and mineral supplements	2.0	2.7	4.2	0.6	2.1	-1.9
Supplements: Zinc	2.9	3.2	7.6	-2.8	-1.0	1.0
Medication: Co-codamol	0.2	0.3	0.8	0.9	0.1	-0.1
Medication: Metformin	0.9	1.3	2.7	-1.6	-0.8	0.8
Diabetes (father)	2.3	2.8	3.3	1.5	-1.8	1.7
Diabetes (mother)	0.1	0.1	0.2	0.0	0.5	-0.3
Severe depression (siblings)	0.9	1.0	1.1	-0.8	-1.0	1.1
Pack years adult smoking proportion	1.4	2.1	3.5	-0.8	-1.9	1.4
Impedance of leg (right)	0.5	2.4	3.5	0.7	1.9	-1.8
Leg fat-free mass (left)	0.3	1.6	4.9	-2.2	0.0	-0.1
Trunk fat percentage	0.2	0.8	1.3	-0.5	-0.9	1.2
Hand grip strength (right)	1.1	3.0	6.9	-2.6	0.9	-1.1
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.2	-0.6	0.5
Current tobacco smoking	4.1	6.7	10.4	-0.4	-3.2	3.1
Average weekly fortified wine intake	0.7	0.8	1.5	-0.6	-1.2	0.8
Maternal smoking around birth	2.8	4.1	4.5	-1.9	-2.1	2.0
Fed-up feelings	0.8	1.5	2.7	-0.7	-1.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.6	-0.1	0.1
Relative age voice broke	0.9	1.3	2.1	-0.6	1.2	-1.4
Taking other prescription medications	0.2	0.3	0.8	-0.9	-0.3	0.3
Age when periods started (menarche)	0.4	0.9	1.3	-0.8	1.1	-0.9
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	4.1	-2.0	0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	2.8	1.6	-1.6	1.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.4	0.4	-0.6	0.5
Qualifications: CSEs or equivalent	0.0	0.0	0.1	-0.2	-0.2	0.0
Serious illness, injury or assault to yourself	1.0	1.2	1.7	-0.9	1.1	-1.3
High blood pressure	0.7	2.0	2.8	-0.6	-1.7	1.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	1.0	-0.6	0.5
Multivitamins +/- minerals	3.0	3.8	5.7	-0.5	-2.4	2.3
Stomach or abdominal pain in last month	3.3	4.1	4.7	-1.9	1.9	-2.2
Supplements: Glucosamine	3.0	4.0	5.8	-0.7	-2.4	2.3
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.1	-0.8	-1.0	1.0
Medication: Atenolol	0.8	1.0	1.1	1.0	1.1	-0.9
Medication: Levothyroxine sodium	0.6	1.0	1.5	-0.3	-1.2	1.1
Sitting height	0.9	6.4	8.6	-1.7	2.8	-2.9
Chronic bronchitis/emphysema (father)	0.7	0.8	2.1	-1.4	-0.3	0.6
High blood pressure (mother)	0.1	0.1	0.1	-0.3	0.1	-0.4
Body mass index (BMI)	0.7	2.9	4.1	-0.9	-1.9	2.0
Impedance of leg (left)	0.5	2.4	3.7	0.2	1.9	-1.8
Leg predicted mass (left)	0.3	1.7	5.0	-2.2	0.0	-0.1
Trunk fat mass	0.2	1.0	1.5	-1.2	-0.8	1.0
Waist circumference	0.7	2.5	3.6	-0.6	-1.8	1.9
Number of incorrect matches in round	0.1	0.1	0.1	-0.4	0.1	0.4
Past tobacco smoking	0.6	1.2	1.6	0.7	1.3	-1.2
Alcohol usually taken with meals	1.7	2.8	4.1	-0.7	2.0	-1.9
Nervous feelings	1.3	2.4	4.0	0.2	-1.8	2.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.7	-0.6	-1.0	1.3
Hearing difficulty/problems with background noise	2.1	3.4	5.0	0.2	-2.2	2.2
Hair/balding pattern: Pattern 2	0.3	0.3	0.5	0.5	-0.7	0.5
Had menopause	0.1	0.1	0.2	0.3	0.4	-0.2
Had other major operations	0.7	0.8	1.0	0.8	-0.9	1.0
Forced vital capacity (FVC)	0.6	2.3	6.9	-2.6	0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.0	1.0	-1.0	1.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.6	-0.5	0.1
Qualifications: None of the above	0.1	0.3	0.4	-0.5	-0.6	0.5
Financial difficulties in last 2 years	0.2	0.2	0.3	-0.6	-0.4	0.5
Mouth/teeth dental problems	1.4	2.2	3.7	-0.7	1.5	-1.9
Heart attack	0.0	0.0	0.1	-0.1	-0.2	0.2
Allergy	0.7	1.5	2.7	-1.6	1.0	-0.9
Pain all over the body in last month	0.2	0.2	0.4	0.6	0.3	-0.3
Diabetes (self-reported)	1.6	2.4	3.6	0.4	-1.8	1.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	0.6	-0.5	0.5
Medication: Ramipril	1.8	2.4	3.3	-0.8	1.8	-1.8
Medication: Simvastatin	0.6	0.9	2.0	-1.4	-0.6	0.7
Fluid intelligence score	0.0	0.0	0.0	-0.1	-0.0	-0.1
Illnesses of siblings	0.8	1.2	1.6	1.3	0.8	-1.1
Neuroticism score	2.5	5.2	7.3	-1.3	-2.5	2.7
Weight	0.4	2.1	5.6	-2.4	-0.5	0.6
Impedance of arm (right)	0.1	0.6	1.3	1.1	0.6	-0.4
Arm fat percentage (right)	0.7	3.0	4.6	-0.7	-1.9	2.2
Trunk fat-free mass	0.7	4.2	12.1	-3.5	0.4	-0.6
Hip circumference	0.0	0.1	0.2	-0.4	0.0	0.0
Time employed in main current job	3.5	4.0	6.6	0.8	2.6	-2.2
Alcohol intake versus 10 years previously	0.1	0.1	0.1	-0.2	0.3	-0.4
Father’s age at death	0.7	0.9	1.2	0.7	1.0	-1.1
Worrier / anxious feelings	4.2	8.0	12.0	-0.0	-3.5	3.4
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	4.0	-1.9	-1.8	2.0
Falls in the last year	2.5	3.4	4.8	-1.4	-1.9	2.2
Hair/balding pattern: Pattern 3	0.8	1.2	2.0	-1.4	0.9	-0.9
Number of live births	0.4	0.5	0.8	0.7	0.9	-0.5
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	8.3	-2.9	-0.2	0.3
Pulse rate	0.9	1.5	2.0	-0.8	-1.4	1.4
Happiness	0.2	0.3	0.5	-0.3	-0.7	0.5
Noisy workplace	3.0	3.7	5.5	-0.5	-2.3	2.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	-0.8	-0.2	0.1
Serious illness, injury or assault of a close relative in last 2 years	3.0	3.5	6.4	-2.5	-1.5	1.3
Mouth/teeth dental problems: Dentures	1.2	2.0	2.6	-1.4	-1.2	1.6
Asthma	1.0	2.0	5.8	2.4	-0.4	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.1	0.5	0.0
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.5	0.2	-0.2
Depression (self-reported)	1.7	2.0	5.5	-2.3	-0.5	0.5
Medication: Lansoprazole	0.1	0.1	0.2	-0.4	-0.2	0.5
Prospective memory result	1.1	1.4	3.8	-2.0	0.5	-0.4
Lung cancer (father)	0.7	0.8	1.2	-0.7	-1.1	0.8
Illnesses of mother	0.2	0.3	0.8	0.9	0.3	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	11.2	-3.3	0.6	-0.5
Pulse wave Arterial Stiffness index	1.7	2.0	2.5	-1.6	-1.4	1.3
Impedance of arm (left)	0.1	0.7	1.0	1.0	0.8	-0.6
Arm fat mass (right)	0.5	2.1	2.3	-1.4	-1.4	1.5
Trunk predicted mass	0.7	4.0	11.6	-3.4	0.4	-0.6
Standing height	1.1	10.6	13.9	-3.7	3.0	-3.0
Length of working week for main job	0.0	0.0	0.0	0.2	-0.2	0.1
Exposure to tobacco smoke at home	1.4	1.6	2.5	1.6	-1.0	1.1
Breastfed as a baby	0.7	0.9	1.0	-0.9	1.0	-1.0
Tense / ‘highly strung’	2.1	3.5	5.4	-0.1	-2.3	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.0	-1.4	-1.1	1.0
Hair/balding pattern: Pattern 4	0.9	2.2	3.8	0.1	-1.7	1.9
Birth weight of first child	0.6	1.1	1.3	-1.1	-1.0	1.0
Peak expiratory flow (PEF)	0.5	1.2	3.2	-1.8	-0.4	0.5
Pulse wave reflection index	0.8	1.0	1.6	0.0	-1.3	1.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	0.8	-0.8	-0.9	0.7
Loud music exposure frequency	0.4	0.4	1.0	-1.0	-0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.3	0.9	-1.2	1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	0.9	0.3	-1.0	1.0
Blood clot in the leg (DVT)	0.3	0.4	0.7	-0.2	-0.8	0.7
Medication: Paracetamol	0.2	0.3	0.5	0.4	-0.5	0.7
Headache pain in last month	1.7	3.0	4.6	-2.1	-1.4	1.6
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	0.3	-0.3	0.1
Glaucoma (self-reported)	2.6	3.1	6.1	2.5	1.2	-1.3
Gout (self-reported)	0.2	0.2	0.6	-0.8	-0.0	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	0.1	-0.6	0.7
Medication: Amlodipine	1.5	2.1	3.2	0.4	-1.8	1.7
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.2	0.0	0.4	-0.1
Birth weight	0.4	0.9	2.7	-1.6	-0.2	0.3
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.1	1.0	-0.7	0.6
High blood pressure (siblings)	0.6	0.9	1.0	-1.0	-0.9	1.0
Forced vital capacity (FVC), Best measure	0.7	2.7	7.9	-2.8	0.2	-0.3
Body fat percentage	0.3	1.3	2.3	-0.4	-1.2	1.5
Leg fat percentage (right)	0.4	1.3	2.3	-0.3	-1.2	1.5
Arm fat-free mass (right)	0.6	2.9	8.0	-2.8	0.5	-0.7
Exposure to tobacco smoke outside home	0.2	0.3	0.4	-0.7	-0.5	0.5
Comparative body size at age 10	1.3	3.5	4.3	2.1	-1.7	1.8
Number of full brothers	0.2	0.2	0.5	-0.0	0.7	-0.4
Worry too long after embarrassment	1.9	3.1	3.7	-1.9	-1.6	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.0	-0.7	-1.7	1.4
Wheeze or whistling in the chest in last year	1.5	2.7	3.8	1.0	-1.8	1.9
Number of children fathered	0.6	0.6	1.1	-1.0	-0.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.2	1.1	0.9	-1.0
Age at first live birth	0.1	0.2	0.2	0.4	0.4	-0.4
Pulse wave peak to peak time	1.7	2.0	2.2	1.4	1.5	-1.4
Health satisfaction	2.8	3.6	6.1	-2.5	-1.5	1.5
Shortness of breath walking on level ground	2.0	2.4	6.4	2.5	-0.6	0.7
Qualifications: College or University degree	0.4	1.2	2.2	0.0	1.2	-1.5
Eye problems/disorders: None of the above	1.2	1.4	2.1	-0.5	-1.4	1.4
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.0	-0.1	0.2
Emphysema/chronic bronchitis	3.6	4.0	5.0	1.7	-2.1	2.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.6	0.3	-0.4
Neck or shoulder pain in last month	4.0	5.7	9.3	-0.7	-2.7	3.1
Medication: Blood pressure	0.2	0.4	1.1	-1.0	0.4	-0.1
Angina (self-reported)	0.2	0.3	0.4	-0.4	0.5	-0.6
Migraine (self-reported)	1.4	1.7	2.0	1.4	-1.2	1.3
Medication: Ibuprofen	0.4	0.4	0.8	0.5	0.9	-0.5
Medication: Allopurinol	1.3	1.7	2.7	-0.9	-1.3	1.6
Medication: Omeprazole	0.1	0.2	0.3	0.2	-0.6	0.4
Medication: Seretide 50 evohaler	2.4	2.7	3.6	1.3	-1.9	1.7
Mean time to correctly identify matches	0.2	0.4	0.6	0.6	0.8	-0.4
Heart disease (mother)	0.2	0.3	0.5	-0.7	-0.5	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	0.6	0.2	0.0
Whole body fat mass	0.3	1.4	1.9	-1.4	-1.0	1.2
Leg fat mass (right)	0.2	0.9	1.7	-1.3	-0.6	0.8
Arm predicted mass (right)	0.5	2.8	7.1	-2.7	0.7	-0.8
Pulse rate, automated reading	1.0	3.4	4.4	-2.1	-1.8	1.6
Alcohol intake frequency.	0.0	0.1	0.2	-0.4	0.0	-0.2
Comparative height size at age 10	1.4	7.5	13.0	-3.6	2.0	-2.4
Number of full sisters	0.6	0.7	1.1	0.1	1.0	-1.1
Suffer from ‘nerves’	2.1	3.3	5.2	-0.7	-2.1	2.3
Overall health rating	1.0	2.2	3.1	-1.8	-1.2	1.4
Chest pain or discomfort	0.3	0.4	0.7	-0.8	-0.7	0.4
Had major operations	0.5	0.6	0.8	-0.2	-0.9	0.9
Age at last live birth	1.3	1.8	2.9	0.0	1.7	-1.6
Family relationship satisfaction	0.1	0.1	0.2	-0.4	-0.2	0.1
Leg pain on walking	0.5	0.6	0.8	-0.9	-0.7	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.6	-1.3	-1.0	1.1
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.0	0.8	-1.4	0.9
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.7	1.3	-0.9	1.0
Medication: Aspirin	0.4	0.5	0.8	-0.4	0.7	-0.9
Supplements: Vitamin C	1.6	1.8	3.0	-0.4	-1.7	1.6
Knee pain experienced in last month	3.1	4.9	5.3	-2.0	-2.3	2.3
Hypertension (Self-reported)	0.6	1.8	2.6	-0.6	-1.6	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.9	4.5	7.0	-0.4	2.5	-2.6
Illnesses of father: Heart disease	1.4	2.0	3.4	1.9	-1.1	1.1
Illnesses of siblings: Diabetes	0.5	0.6	0.7	-0.9	-0.8	0.7
Smoking status: Previous	0.8	1.3	2.1	-1.5	-1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.7	-1.1	1.0	-1.3
Whole body fat-free mass	0.6	3.2	9.1	-3.0	0.4	-0.6
Leg fat-free mass (right)	0.4	1.9	5.8	-2.4	-0.1	-0.0
Arm fat percentage (left)	0.7	2.7	4.3	-0.7	-1.9	2.1
Average weekly red wine intake	1.0	1.4	1.8	1.1	1.2	-1.3
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.4	0.3	-0.9	1.2
Mood swings	0.8	1.4	3.4	-1.8	0.6	-0.6
Loneliness, isolation	5.3	7.3	11.5	-0.1	-3.2	3.4
Long-standing illness, disability or infirmity	0.5	0.8	1.2	-1.1	-0.8	0.8
Ever had bowel cancer screening	0.2	0.2	0.4	0.1	-0.6	0.6
Diabetes diagnosed by doctor	1.7	2.8	4.1	-0.4	-2.0	2.0
Ever had stillbirth, spontaneous miscarriage or termination	3.7	3.9	6.1	0.5	-2.5	2.3
Friendships satisfaction	0.3	0.3	1.0	-1.0	-0.1	0.0
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.2	-0.8	0.6
Commuting to job workplace: Walk	3.3	3.6	5.2	0.9	2.3	-2.2
Eye problems/disorders: Cataract	0.5	0.6	0.9	-0.2	0.9	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.6	1.6	-0.8	0.9
Medication for cholesterol	1.9	2.8	3.7	1.2	1.9	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.3	1.5	-0.2	0.2
Back pain experienced in last month	3.6	5.2	7.0	-1.6	-2.4	2.6
Mineral and other dietary supplements	0.8	1.0	1.4	0.9	1.2	-0.9
Breast cancer (self-reported)	1.2	1.4	2.2	0.4	1.4	-1.5
Asthma (self-reported)	0.9	1.7	5.1	2.3	0.0	-0.2
Osteoporosis (self-reported)	2.1	2.6	3.9	0.5	-2.0	1.9
Osteoarthritis (self-reported)	2.8	3.6	5.6	-0.7	-2.2	2.4
Medication: Aspirin	0.3	0.4	0.7	-0.1	0.7	-0.8
Medication: Gliclazide	1.2	1.3	3.3	-1.8	-0.5	0.7
Illnesses of father: None of the above (group 1)	4.2	5.2	6.2	-2.1	2.2	-2.5
Smoking status: Current	4.4	6.9	10.7	-0.6	-3.3	3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	4.8	-2.2	0.6	-0.4
Whole body water mass	0.6	3.5	10.2	-3.2	0.3	-0.5
Leg predicted mass (right)	0.4	2.1	6.2	-2.5	0.0	-0.1
Arm fat mass (left)	0.5	1.9	2.4	-1.5	-1.2	1.4
Number of self-reported non-cancer illnesses	0.4	0.8	2.1	-1.4	-0.3	0.4
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.1	-0.0	-0.5
Miserableness	0.4	0.6	1.7	-1.3	-0.1	0.4
Guilty feelings	1.5	2.2	3.1	-1.2	-1.5	1.7
Wears glasses or contact lenses	0.4	0.5	0.7	-0.8	-0.6	0.7
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.1	-0.6	0.3
Hearing aid user	0.9	1.0	3.0	1.7	-0.1	0.2
Mother’s age at death	0.8	1.0	1.3	1.2	1.0	-0.9
Financial situation satisfaction	0.6	0.7	1.4	-1.2	-0.5	0.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	1.2	-0.4	0.6
Commuting to job workplace: Public transport	0.8	1.0	1.4	-1.1	1.2	-0.7
Eye problems/disorders: Glaucoma	0.7	0.8	1.4	1.2	0.7	-0.7
Medication: Blood pressure	1.0	2.0	2.5	1.0	-1.6	1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.1	-0.9	-0.9	1.1
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.2	-0.5	-2.1	1.9
High cholesterol (Self-reported)	1.0	1.8	3.7	-1.9	-0.8	1.0
Medication: Bendroflumethiazide	0.5	0.8	1.7	0.1	-0.8	1.3
Medication: Paracetamol	0.2	0.3	0.5	0.7	-0.3	0.4
Medication: Lisinopril	0.0	0.0	0.1	-0.1	-0.1	0.2
Medication: Atorvastatin	0.2	0.2	0.4	0.6	-0.4	0.5
Illnesses of father: High blood pressure	0.5	0.6	0.7	0.9	-0.8	0.6
Alcohol drinker status: Never	0.7	0.8	2.4	-1.5	0.2	-0.2
Ever smoked	0.7	1.3	1.9	0.3	-1.4	1.4
Basal metabolic rate	0.5	2.8	8.3	-2.9	0.2	-0.3
Leg fat percentage (left)	0.5	2.0	3.2	-0.6	-1.5	1.8
Arm fat-free mass (left)	0.5	2.6	7.6	-2.8	0.3	-0.4
Number of operations (self-reported)	1.1	1.6	1.9	-1.4	-1.2	1.3
Average weekly beer plus cider intake	1.1	1.6	2.1	-1.0	-1.4	1.4
Irritability	0.1	0.2	0.5	-0.7	-0.0	-0.0
Risk taking	2.4	3.6	10.6	-3.2	-0.3	0.0
Ever had prostate specific antigen (PSA) test	3.8	4.4	6.7	-0.1	2.6	-2.5
Fractured/broken bones in last 5 years	0.6	0.8	2.1	1.5	0.4	-0.2
Age started oral contraceptive pill	0.4	0.4	0.8	0.2	0.9	-0.7
Diastolic blood pressure, automated reading	0.5	1.5	2.1	-1.4	-1.3	0.8
Ever depressed for a whole week	0.2	0.2	0.6	0.8	-0.1	-0.2
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.3	0.9	-0.7
Commuting to job workplace: Cycle	0.8	1.0	1.0	1.0	1.0	-1.0
Myopia	2.3	3.3	4.9	-2.2	-1.5	1.6
Vascular/heart problems diagnosed by doctor	0.4	1.0	1.4	0.7	1.1	-1.2
Cholesterol lowering medication	1.1	1.6	4.1	-2.0	-0.6	0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.8	0.5	-1.3	1.1
Pain experienced in last month	3.2	5.3	9.8	3.1	1.7	-1.9
Supplements: Calcium	4.4	4.9	5.8	-2.4	-2.2	2.0
Basal cell carcinoma (self-reported)	3.4	4.0	4.9	-1.8	-2.0	2.2
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	0.0	-0.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.5	-0.3	-0.7	0.7
Heart disease (siblings)	0.0	0.0	0.0	0.0	0.0	0.1
Alcohol drinker status: Previous	1.1	1.2	1.7	1.3	-0.9	1.0
Pack years of smoking	1.0	1.5	2.2	-1.1	-1.5	1.1
Impedance of whole body	0.4	1.9	2.4	1.2	1.6	-1.3
Leg fat mass (left)	0.3	1.3	2.5	-1.6	-0.7	0.9
Arm predicted mass (left)	0.6	2.8	8.0	-2.8	0.4	-0.6