Hub : Genes

BLCAP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.1970 0.0810 5.4e-03 -0.006 NA 0.020 NA -0.008 6.1e-01 NA 6.6e-02 NA 8.8e-01
2 GTEx Esophagus Mucosa 0.0740 0.0300 3.4e-03 0.077 NA 0.054 NA 0.070 7.8e-06 NA 1.7e-04 NA 2.0e-05
3 NTR Blood 0.0305 0.0104 1.3e-05 0.027 0.022 0.024 0.025 0.025 3.8e-09 9.8e-08 2.1e-08 1.2e-08 1.2e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 0.9 1.1 -0.8 -0.9 1.1
Bipolar Disorder or Schizophrenia 0.8 1.9 2.5 -1.6 -1.2 1.3
Depressed Affect (Nagel 2018) 0.9 2.0 3.1 -1.0 -1.3 1.8
Depression (Nagel 2018) 0.6 0.8 2.3 -1.5 0.4 -0.2
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.8 0.9 -0.1 0.4
Neuroticism (Nagel 2018) 2.2 5.2 7.8 -1.2 -2.5 2.8
Schizophrenia (2018) 0.5 1.1 1.8 -1.3 -0.8 0.8
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 -0.7 0.1 0.3
Worry (Nagel 2018) 4.1 8.7 13.1 -0.0 -3.6 3.6
Alzheimer’s Disease (in mother) 2.4 2.9 6.8 -2.6 -1.1 0.7
Alzheimer’s Disease (in father) 0.7 0.7 1.2 0.4 -0.9 1.1
Alzheimer’s Disease (including proxy) 0.7 1.0 1.3 -1.1 -0.9 1.0
Crohns Disease (2017) 0.2 0.5 0.8 -0.3 -0.7 0.9
Irritable Bowel Disease (IBD) 0.4 0.8 1.8 1.4 0.6 -0.5
Ulcerative Colitis (UC) 1.8 3.3 4.9 2.2 1.6 -1.6
Major Depression (MDD) 1.8 2.2 4.5 -2.1 -1.2 0.7
Reaction Time 0.2 0.3 0.9 0.9 0.1 0.3
Verbal and Numeric Reasoning (VNR) 0.0 0.0 0.1 0.2 0.2 -0.2
Breast Cancer 0.3 0.8 1.3 -1.1 -0.8 0.7
Ovarian Cancer 2.2 2.9 8.2 2.9 -0.4 0.5
Prostate Cancer 0.2 0.3 0.4 0.3 -0.6 0.6
Age at First Birth 0.5 0.7 1.0 0.6 0.9 -1.0
Bipolar Disorder (2011) 0.2 0.2 0.3 -0.6 0.1 -0.4
Body Mass Index (BMI) (2010) 0.9 1.2 2.1 -0.0 -1.4 1.2
Coronary Artery Disease (CAD) 0.2 0.3 0.7 -0.8 0.2 -0.3
Crohns Disease (2012) 0.1 0.2 0.3 -0.6 -0.4 0.2
Mean Putamen Volume 0.6 0.7 0.8 0.7 -0.9 0.8
Fasting Glucose 2.1 2.5 2.7 1.6 1.5 -1.6
HbA1C 0.7 0.7 2.1 -1.4 -0.3 0.1
HDL Cholesterol 0.6 0.9 1.1 -0.8 1.1 -1.0
LDL Cholesterol 0.5 0.8 2.4 1.5 -0.4 0.1
Lupus 0.3 0.5 0.6 0.6 0.7 -0.7
Neuroticism (2016) 0.4 0.6 1.2 -1.1 -0.5 0.5
Primary Biliary Cirrhosis 0.8 1.1 2.1 -1.4 0.7 -0.9
Rheumatoid Arthritis 2.8 3.8 5.7 0.7 2.3 -2.4
Schizophrenia (2014) 0.7 1.6 1.9 -1.1 -1.4 1.4
Triglycerides 0.0 0.0 0.0 0.1 0.1 -0.1
Type 2 Diabetes (T2D) (2012) 1.4 1.6 2.5 0.9 -1.6 1.3
Ulcerative Colitis 0.3 0.4 0.8 0.9 0.4 -0.5
Blood Eosinophil Count 0.3 2.5 3.5 -0.8 -1.8 1.9
Blood Platelet Count 0.0 0.5 0.7 0.5 -0.7 0.8
Blood Red Count 0.1 1.0 1.1 -1.0 -0.9 1.1
Blood White Count 0.4 3.1 4.8 -0.6 -2.2 2.0
Heel T-Score 0.1 1.1 3.2 1.8 0.1 -0.0
BMI 0.6 3.4 5.2 -0.4 -2.3 2.2
Height 1.3 25.8 46.2 -6.8 4.0 -3.9
Waist Hip Ratio (WHR) 0.5 2.1 2.7 1.3 -1.4 1.6
Systolic Blood Pressure 0.0 0.2 0.3 0.3 -0.6 0.4
Smoking Status 5.5 13.2 20.2 -1.5 -4.5 4.1
Allergy or Eczema 0.2 0.5 0.8 0.5 -0.9 0.7
Cardiovascular Disease 0.0 0.1 0.1 -0.3 -0.3 -0.1
Hypothyroidism (self reported) 0.1 0.3 0.4 0.6 0.6 -0.3
Respiratory disease 1.0 2.2 6.6 2.6 -0.2 0.1
Type 2 Diabetes (T2D) (2018) 1.4 2.6 4.2 -0.1 -2.1 1.9
Lung FEV1/FVC ratio 0.3 1.4 1.9 -1.2 -0.9 1.4
Lung FVC 1.2 6.2 7.2 -2.0 -2.7 2.7
Neuroticism 2.0 4.8 6.2 -1.7 -2.4 2.5
Chronotype (morning person) 0.7 1.6 2.7 1.6 -1.0 1.0
Hair Pigment 0.0 0.5 0.7 -0.9 -0.5 0.8
Tanning 0.4 5.4 8.8 3.0 -2.1 1.7
Hand grip strength (left) 0.5 1.2 3.2 -1.8 0.4 -0.5
Number of treatments/medications taken 0.2 0.3 0.6 -0.4 -0.6 0.8
Average weekly spirits intake 1.4 1.7 1.8 1.2 -1.3 1.3
Sensitivity / hurt feelings 2.1 3.6 4.5 -1.6 -2.1 2.0
Frequency of depressed mood in last 2 weeks 2.1 2.9 8.7 -3.0 0.0 0.2
Hearing difficulty/problems: Yes 7.4 11.3 15.8 1.9 -3.8 4.0
Relative age of first facial hair 0.4 0.8 2.2 -1.5 -0.3 0.3
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 6.1 -2.5 -0.6 0.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.4 -0.5 -1.2 0.9
Ever had hysterectomy (womb removed) 0.6 0.7 1.1 0.2 -0.9 1.0
Systolic blood pressure, automated reading 0.3 0.8 1.1 -0.7 0.9 -1.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 0.2 -0.4 0.5
Angina 0.1 0.2 0.3 -0.3 0.4 -0.5
Medication for hormone replacement therapy 0.3 0.4 0.5 -0.6 -0.7 0.6
Vitamin and mineral supplements 2.0 2.7 4.2 0.6 2.1 -1.9
Supplements: Zinc 2.9 3.2 7.6 -2.8 -1.0 1.0
Medication: Co-codamol 0.2 0.3 0.8 0.9 0.1 -0.1
Medication: Metformin 0.9 1.3 2.7 -1.6 -0.8 0.8
Diabetes (father) 2.3 2.8 3.3 1.5 -1.8 1.7
Diabetes (mother) 0.1 0.1 0.2 0.0 0.5 -0.3
Severe depression (siblings) 0.9 1.0 1.1 -0.8 -1.0 1.1
Pack years adult smoking proportion 1.4 2.1 3.5 -0.8 -1.9 1.4
Impedance of leg (right) 0.5 2.4 3.5 0.7 1.9 -1.8
Leg fat-free mass (left) 0.3 1.6 4.9 -2.2 0.0 -0.1
Trunk fat percentage 0.2 0.8 1.3 -0.5 -0.9 1.2
Hand grip strength (right) 1.1 3.0 6.9 -2.6 0.9 -1.1
Townsend deprivation index at recruitment 0.1 0.2 0.3 0.2 -0.6 0.5
Current tobacco smoking 4.1 6.7 10.4 -0.4 -3.2 3.1
Average weekly fortified wine intake 0.7 0.8 1.5 -0.6 -1.2 0.8
Maternal smoking around birth 2.8 4.1 4.5 -1.9 -2.1 2.0
Fed-up feelings 0.8 1.5 2.7 -0.7 -1.2 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.3 -0.6 -0.1 0.1
Relative age voice broke 0.9 1.3 2.1 -0.6 1.2 -1.4
Taking other prescription medications 0.2 0.3 0.8 -0.9 -0.3 0.3
Age when periods started (menarche) 0.4 0.9 1.3 -0.8 1.1 -0.9
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 4.1 -2.0 0.7 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 2.8 1.6 -1.6 1.7
Tinnitus: Yes, but not now, but have in the past 0.2 0.3 0.4 0.4 -0.6 0.5
Qualifications: CSEs or equivalent 0.0 0.0 0.1 -0.2 -0.2 0.0
Serious illness, injury or assault to yourself 1.0 1.2 1.7 -0.9 1.1 -1.3
High blood pressure 0.7 2.0 2.8 -0.6 -1.7 1.7
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.0 1.0 -0.6 0.5
Multivitamins +/- minerals 3.0 3.8 5.7 -0.5 -2.4 2.3
Stomach or abdominal pain in last month 3.3 4.1 4.7 -1.9 1.9 -2.2
Supplements: Glucosamine 3.0 4.0 5.8 -0.7 -2.4 2.3
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.1 -0.8 -1.0 1.0
Medication: Atenolol 0.8 1.0 1.1 1.0 1.1 -0.9
Medication: Levothyroxine sodium 0.6 1.0 1.5 -0.3 -1.2 1.1
Sitting height 0.9 6.4 8.6 -1.7 2.8 -2.9
Chronic bronchitis/emphysema (father) 0.7 0.8 2.1 -1.4 -0.3 0.6
High blood pressure (mother) 0.1 0.1 0.1 -0.3 0.1 -0.4
Body mass index (BMI) 0.7 2.9 4.1 -0.9 -1.9 2.0
Impedance of leg (left) 0.5 2.4 3.7 0.2 1.9 -1.8
Leg predicted mass (left) 0.3 1.7 5.0 -2.2 0.0 -0.1
Trunk fat mass 0.2 1.0 1.5 -1.2 -0.8 1.0
Waist circumference 0.7 2.5 3.6 -0.6 -1.8 1.9
Number of incorrect matches in round 0.1 0.1 0.1 -0.4 0.1 0.4
Past tobacco smoking 0.6 1.2 1.6 0.7 1.3 -1.2
Alcohol usually taken with meals 1.7 2.8 4.1 -0.7 2.0 -1.9
Nervous feelings 1.3 2.4 4.0 0.2 -1.8 2.0
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 1.7 -0.6 -1.0 1.3
Hearing difficulty/problems with background noise 2.1 3.4 5.0 0.2 -2.2 2.2
Hair/balding pattern: Pattern 2 0.3 0.3 0.5 0.5 -0.7 0.5
Had menopause 0.1 0.1 0.2 0.3 0.4 -0.2
Had other major operations 0.7 0.8 1.0 0.8 -0.9 1.0
Forced vital capacity (FVC) 0.6 2.3 6.9 -2.6 0.1 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.0 1.0 -1.0 1.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.4 0.6 -0.5 0.1
Qualifications: None of the above 0.1 0.3 0.4 -0.5 -0.6 0.5
Financial difficulties in last 2 years 0.2 0.2 0.3 -0.6 -0.4 0.5
Mouth/teeth dental problems 1.4 2.2 3.7 -0.7 1.5 -1.9
Heart attack 0.0 0.0 0.1 -0.1 -0.2 0.2
Allergy 0.7 1.5 2.7 -1.6 1.0 -0.9
Pain all over the body in last month 0.2 0.2 0.4 0.6 0.3 -0.3
Diabetes (self-reported) 1.6 2.4 3.6 0.4 -1.8 1.9
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.4 0.6 -0.5 0.5
Medication: Ramipril 1.8 2.4 3.3 -0.8 1.8 -1.8
Medication: Simvastatin 0.6 0.9 2.0 -1.4 -0.6 0.7
Fluid intelligence score 0.0 0.0 0.0 -0.1 -0.0 -0.1
Illnesses of siblings 0.8 1.2 1.6 1.3 0.8 -1.1
Neuroticism score 2.5 5.2 7.3 -1.3 -2.5 2.7
Weight 0.4 2.1 5.6 -2.4 -0.5 0.6
Impedance of arm (right) 0.1 0.6 1.3 1.1 0.6 -0.4
Arm fat percentage (right) 0.7 3.0 4.6 -0.7 -1.9 2.2
Trunk fat-free mass 0.7 4.2 12.1 -3.5 0.4 -0.6
Hip circumference 0.0 0.1 0.2 -0.4 0.0 0.0
Time employed in main current job 3.5 4.0 6.6 0.8 2.6 -2.2
Alcohol intake versus 10 years previously 0.1 0.1 0.1 -0.2 0.3 -0.4
Father’s age at death 0.7 0.9 1.2 0.7 1.0 -1.1
Worrier / anxious feelings 4.2 8.0 12.0 -0.0 -3.5 3.4
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.6 4.0 -1.9 -1.8 2.0
Falls in the last year 2.5 3.4 4.8 -1.4 -1.9 2.2
Hair/balding pattern: Pattern 3 0.8 1.2 2.0 -1.4 0.9 -0.9
Number of live births 0.4 0.5 0.8 0.7 0.9 -0.5
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 8.3 -2.9 -0.2 0.3
Pulse rate 0.9 1.5 2.0 -0.8 -1.4 1.4
Happiness 0.2 0.3 0.5 -0.3 -0.7 0.5
Noisy workplace 3.0 3.7 5.5 -0.5 -2.3 2.3
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.7 -0.8 -0.2 0.1
Serious illness, injury or assault of a close relative in last 2 years 3.0 3.5 6.4 -2.5 -1.5 1.3
Mouth/teeth dental problems: Dentures 1.2 2.0 2.6 -1.4 -1.2 1.6
Asthma 1.0 2.0 5.8 2.4 -0.4 0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 -0.1 0.5 0.0
Medication: Cholesterol lowering 0.1 0.1 0.3 -0.5 0.2 -0.2
Depression (self-reported) 1.7 2.0 5.5 -2.3 -0.5 0.5
Medication: Lansoprazole 0.1 0.1 0.2 -0.4 -0.2 0.5
Prospective memory result 1.1 1.4 3.8 -2.0 0.5 -0.4
Lung cancer (father) 0.7 0.8 1.2 -0.7 -1.1 0.8
Illnesses of mother 0.2 0.3 0.8 0.9 0.3 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.9 11.2 -3.3 0.6 -0.5
Pulse wave Arterial Stiffness index 1.7 2.0 2.5 -1.6 -1.4 1.3
Impedance of arm (left) 0.1 0.7 1.0 1.0 0.8 -0.6
Arm fat mass (right) 0.5 2.1 2.3 -1.4 -1.4 1.5
Trunk predicted mass 0.7 4.0 11.6 -3.4 0.4 -0.6
Standing height 1.1 10.6 13.9 -3.7 3.0 -3.0
Length of working week for main job 0.0 0.0 0.0 0.2 -0.2 0.1
Exposure to tobacco smoke at home 1.4 1.6 2.5 1.6 -1.0 1.1
Breastfed as a baby 0.7 0.9 1.0 -0.9 1.0 -1.0
Tense / ‘highly strung’ 2.1 3.5 5.4 -0.1 -2.3 2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.0 -1.4 -1.1 1.0
Hair/balding pattern: Pattern 4 0.9 2.2 3.8 0.1 -1.7 1.9
Birth weight of first child 0.6 1.1 1.3 -1.1 -1.0 1.0
Peak expiratory flow (PEF) 0.5 1.2 3.2 -1.8 -0.4 0.5
Pulse wave reflection index 0.8 1.0 1.6 0.0 -1.3 1.2
Ever highly irritable/argumentative for 2 days 0.6 0.7 0.8 -0.8 -0.9 0.7
Loud music exposure frequency 0.4 0.4 1.0 -1.0 -0.3 0.4
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 1.3 0.9 -1.2 1.0
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 0.9 0.3 -1.0 1.0
Blood clot in the leg (DVT) 0.3 0.4 0.7 -0.2 -0.8 0.7
Medication: Paracetamol 0.2 0.3 0.5 0.4 -0.5 0.7
Headache pain in last month 1.7 3.0 4.6 -2.1 -1.4 1.6
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 0.3 -0.3 0.1
Glaucoma (self-reported) 2.6 3.1 6.1 2.5 1.2 -1.3
Gout (self-reported) 0.2 0.2 0.6 -0.8 -0.0 0.3
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.4 0.1 -0.6 0.7
Medication: Amlodipine 1.5 2.1 3.2 0.4 -1.8 1.7
Medication: Ventolin 100micrograms inhaler 0.0 0.1 0.2 0.0 0.4 -0.1
Birth weight 0.4 0.9 2.7 -1.6 -0.2 0.3
Chronic bronchitis/emphysema (mother) 0.6 0.6 1.1 1.0 -0.7 0.6
High blood pressure (siblings) 0.6 0.9 1.0 -1.0 -0.9 1.0
Forced vital capacity (FVC), Best measure 0.7 2.7 7.9 -2.8 0.2 -0.3
Body fat percentage 0.3 1.3 2.3 -0.4 -1.2 1.5
Leg fat percentage (right) 0.4 1.3 2.3 -0.3 -1.2 1.5
Arm fat-free mass (right) 0.6 2.9 8.0 -2.8 0.5 -0.7
Exposure to tobacco smoke outside home 0.2 0.3 0.4 -0.7 -0.5 0.5
Comparative body size at age 10 1.3 3.5 4.3 2.1 -1.7 1.8
Number of full brothers 0.2 0.2 0.5 -0.0 0.7 -0.4
Worry too long after embarrassment 1.9 3.1 3.7 -1.9 -1.6 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 3.0 -0.7 -1.7 1.4
Wheeze or whistling in the chest in last year 1.5 2.7 3.8 1.0 -1.8 1.9
Number of children fathered 0.6 0.6 1.1 -1.0 -0.6 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.2 1.1 0.9 -1.0
Age at first live birth 0.1 0.2 0.2 0.4 0.4 -0.4
Pulse wave peak to peak time 1.7 2.0 2.2 1.4 1.5 -1.4
Health satisfaction 2.8 3.6 6.1 -2.5 -1.5 1.5
Shortness of breath walking on level ground 2.0 2.4 6.4 2.5 -0.6 0.7
Qualifications: College or University degree 0.4 1.2 2.2 0.0 1.2 -1.5
Eye problems/disorders: None of the above 1.2 1.4 2.1 -0.5 -1.4 1.4
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 0.0 -0.1 0.2
Emphysema/chronic bronchitis 3.6 4.0 5.0 1.7 -2.1 2.2
Medication for pain relief, constipation, heartburn 0.1 0.2 0.4 -0.6 0.3 -0.4
Neck or shoulder pain in last month 4.0 5.7 9.3 -0.7 -2.7 3.1
Medication: Blood pressure 0.2 0.4 1.1 -1.0 0.4 -0.1
Angina (self-reported) 0.2 0.3 0.4 -0.4 0.5 -0.6
Migraine (self-reported) 1.4 1.7 2.0 1.4 -1.2 1.3
Medication: Ibuprofen 0.4 0.4 0.8 0.5 0.9 -0.5
Medication: Allopurinol 1.3 1.7 2.7 -0.9 -1.3 1.6
Medication: Omeprazole 0.1 0.2 0.3 0.2 -0.6 0.4
Medication: Seretide 50 evohaler 2.4 2.7 3.6 1.3 -1.9 1.7
Mean time to correctly identify matches 0.2 0.4 0.6 0.6 0.8 -0.4
Heart disease (mother) 0.2 0.3 0.5 -0.7 -0.5 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.4 0.6 0.2 0.0
Whole body fat mass 0.3 1.4 1.9 -1.4 -1.0 1.2
Leg fat mass (right) 0.2 0.9 1.7 -1.3 -0.6 0.8
Arm predicted mass (right) 0.5 2.8 7.1 -2.7 0.7 -0.8
Pulse rate, automated reading 1.0 3.4 4.4 -2.1 -1.8 1.6
Alcohol intake frequency. 0.0 0.1 0.2 -0.4 0.0 -0.2
Comparative height size at age 10 1.4 7.5 13.0 -3.6 2.0 -2.4
Number of full sisters 0.6 0.7 1.1 0.1 1.0 -1.1
Suffer from ‘nerves’ 2.1 3.3 5.2 -0.7 -2.1 2.3
Overall health rating 1.0 2.2 3.1 -1.8 -1.2 1.4
Chest pain or discomfort 0.3 0.4 0.7 -0.8 -0.7 0.4
Had major operations 0.5 0.6 0.8 -0.2 -0.9 0.9
Age at last live birth 1.3 1.8 2.9 0.0 1.7 -1.6
Family relationship satisfaction 0.1 0.1 0.2 -0.4 -0.2 0.1
Leg pain on walking 0.5 0.6 0.8 -0.9 -0.7 0.8
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 1.6 -1.3 -1.0 1.1
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.0 0.8 -1.4 0.9
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.7 1.3 -0.9 1.0
Medication: Aspirin 0.4 0.5 0.8 -0.4 0.7 -0.9
Supplements: Vitamin C 1.6 1.8 3.0 -0.4 -1.7 1.6
Knee pain experienced in last month 3.1 4.9 5.3 -2.0 -2.3 2.3
Hypertension (Self-reported) 0.6 1.8 2.6 -0.6 -1.6 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.9 4.5 7.0 -0.4 2.5 -2.6
Illnesses of father: Heart disease 1.4 2.0 3.4 1.9 -1.1 1.1
Illnesses of siblings: Diabetes 0.5 0.6 0.7 -0.9 -0.8 0.7
Smoking status: Previous 0.8 1.3 2.1 -1.5 -1.0 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 1.7 -1.1 1.0 -1.3
Whole body fat-free mass 0.6 3.2 9.1 -3.0 0.4 -0.6
Leg fat-free mass (right) 0.4 1.9 5.8 -2.4 -0.1 -0.0
Arm fat percentage (left) 0.7 2.7 4.3 -0.7 -1.9 2.1
Average weekly red wine intake 1.0 1.4 1.8 1.1 1.2 -1.3
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.4 0.3 -0.9 1.2
Mood swings 0.8 1.4 3.4 -1.8 0.6 -0.6
Loneliness, isolation 5.3 7.3 11.5 -0.1 -3.2 3.4
Long-standing illness, disability or infirmity 0.5 0.8 1.2 -1.1 -0.8 0.8
Ever had bowel cancer screening 0.2 0.2 0.4 0.1 -0.6 0.6
Diabetes diagnosed by doctor 1.7 2.8 4.1 -0.4 -2.0 2.0
Ever had stillbirth, spontaneous miscarriage or termination 3.7 3.9 6.1 0.5 -2.5 2.3
Friendships satisfaction 0.3 0.3 1.0 -1.0 -0.1 0.0
Qualifications: nursing, teaching 0.2 0.3 0.6 -0.2 -0.8 0.6
Commuting to job workplace: Walk 3.3 3.6 5.2 0.9 2.3 -2.2
Eye problems/disorders: Cataract 0.5 0.6 0.9 -0.2 0.9 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 2.6 1.6 -0.8 0.9
Medication for cholesterol 1.9 2.8 3.7 1.2 1.9 -1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.3 1.5 -0.2 0.2
Back pain experienced in last month 3.6 5.2 7.0 -1.6 -2.4 2.6
Mineral and other dietary supplements 0.8 1.0 1.4 0.9 1.2 -0.9
Breast cancer (self-reported) 1.2 1.4 2.2 0.4 1.4 -1.5
Asthma (self-reported) 0.9 1.7 5.1 2.3 0.0 -0.2
Osteoporosis (self-reported) 2.1 2.6 3.9 0.5 -2.0 1.9
Osteoarthritis (self-reported) 2.8 3.6 5.6 -0.7 -2.2 2.4
Medication: Aspirin 0.3 0.4 0.7 -0.1 0.7 -0.8
Medication: Gliclazide 1.2 1.3 3.3 -1.8 -0.5 0.7
Illnesses of father: None of the above (group 1) 4.2 5.2 6.2 -2.1 2.2 -2.5
Smoking status: Current 4.4 6.9 10.7 -0.6 -3.3 3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 4.8 -2.2 0.6 -0.4
Whole body water mass 0.6 3.5 10.2 -3.2 0.3 -0.5
Leg predicted mass (right) 0.4 2.1 6.2 -2.5 0.0 -0.1
Arm fat mass (left) 0.5 1.9 2.4 -1.5 -1.2 1.4
Number of self-reported non-cancer illnesses 0.4 0.8 2.1 -1.4 -0.3 0.4
Average weekly champagne plus white wine intake 0.1 0.1 0.2 -0.1 -0.0 -0.5
Miserableness 0.4 0.6 1.7 -1.3 -0.1 0.4
Guilty feelings 1.5 2.2 3.1 -1.2 -1.5 1.7
Wears glasses or contact lenses 0.4 0.5 0.7 -0.8 -0.6 0.7
Ever taken oral contraceptive pill 0.2 0.2 0.4 0.1 -0.6 0.3
Hearing aid user 0.9 1.0 3.0 1.7 -0.1 0.2
Mother’s age at death 0.8 1.0 1.3 1.2 1.0 -0.9
Financial situation satisfaction 0.6 0.7 1.4 -1.2 -0.5 0.6
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.5 1.2 -0.4 0.6
Commuting to job workplace: Public transport 0.8 1.0 1.4 -1.1 1.2 -0.7
Eye problems/disorders: Glaucoma 0.7 0.8 1.4 1.2 0.7 -0.7
Medication: Blood pressure 1.0 2.0 2.5 1.0 -1.6 1.5
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.1 -0.9 -0.9 1.1
Supplements: Fish oil (including cod liver oil) 2.1 2.7 4.2 -0.5 -2.1 1.9
High cholesterol (Self-reported) 1.0 1.8 3.7 -1.9 -0.8 1.0
Medication: Bendroflumethiazide 0.5 0.8 1.7 0.1 -0.8 1.3
Medication: Paracetamol 0.2 0.3 0.5 0.7 -0.3 0.4
Medication: Lisinopril 0.0 0.0 0.1 -0.1 -0.1 0.2
Medication: Atorvastatin 0.2 0.2 0.4 0.6 -0.4 0.5
Illnesses of father: High blood pressure 0.5 0.6 0.7 0.9 -0.8 0.6
Alcohol drinker status: Never 0.7 0.8 2.4 -1.5 0.2 -0.2
Ever smoked 0.7 1.3 1.9 0.3 -1.4 1.4
Basal metabolic rate 0.5 2.8 8.3 -2.9 0.2 -0.3
Leg fat percentage (left) 0.5 2.0 3.2 -0.6 -1.5 1.8
Arm fat-free mass (left) 0.5 2.6 7.6 -2.8 0.3 -0.4
Number of operations (self-reported) 1.1 1.6 1.9 -1.4 -1.2 1.3
Average weekly beer plus cider intake 1.1 1.6 2.1 -1.0 -1.4 1.4
Irritability 0.1 0.2 0.5 -0.7 -0.0 -0.0
Risk taking 2.4 3.6 10.6 -3.2 -0.3 0.0
Ever had prostate specific antigen (PSA) test 3.8 4.4 6.7 -0.1 2.6 -2.5
Fractured/broken bones in last 5 years 0.6 0.8 2.1 1.5 0.4 -0.2
Age started oral contraceptive pill 0.4 0.4 0.8 0.2 0.9 -0.7
Diastolic blood pressure, automated reading 0.5 1.5 2.1 -1.4 -1.3 0.8
Ever depressed for a whole week 0.2 0.2 0.6 0.8 -0.1 -0.2
Unable to work because of sickness or disability 0.3 0.4 0.7 -0.3 0.9 -0.7
Commuting to job workplace: Cycle 0.8 1.0 1.0 1.0 1.0 -1.0
Myopia 2.3 3.3 4.9 -2.2 -1.5 1.6
Vascular/heart problems diagnosed by doctor 0.4 1.0 1.4 0.7 1.1 -1.2
Cholesterol lowering medication 1.1 1.6 4.1 -2.0 -0.6 0.5
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 1.8 0.5 -1.3 1.1
Pain experienced in last month 3.2 5.3 9.8 3.1 1.7 -1.9
Supplements: Calcium 4.4 4.9 5.8 -2.4 -2.2 2.0
Basal cell carcinoma (self-reported) 3.4 4.0 4.9 -1.8 -2.0 2.2
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.1 0.0 -0.3 0.3
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.5 -0.3 -0.7 0.7
Heart disease (siblings) 0.0 0.0 0.0 0.0 0.0 0.1
Alcohol drinker status: Previous 1.1 1.2 1.7 1.3 -0.9 1.0
Pack years of smoking 1.0 1.5 2.2 -1.1 -1.5 1.1
Impedance of whole body 0.4 1.9 2.4 1.2 1.6 -1.3
Leg fat mass (left) 0.3 1.3 2.5 -1.6 -0.7 0.9
Arm predicted mass (left) 0.6 2.8 8.0 -2.8 0.4 -0.6