Hub : Genes

BLZF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0570	0.0250	9.8e-03	0.002	0.017	0.016	0.018	0.012	1.8e-01	0.00350	0.00370	0.0027	0.01100
2	TCGA	Bladder Urothelial Carcinoma	0.1960	0.0790	2.1e-06	0.046	0.037	0.039	NA	0.041	8.4e-05	0.00040	0.00031	NA	0.00021
3	TCGA	Breast Invasive Carcinoma	0.0687	0.0339	6.7e-04	0.000	0.008	0.008	NA	0.003	3.6e-01	0.00650	0.00580	NA	0.07700
4	TCGA	Cervical Squamous Cell Carcinoma	0.2830	0.1120	2.8e-03	-0.005	-0.005	-0.005	NA	-0.006	7.0e-01	0.72000	0.69000	NA	0.87000
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0976	0.0516	5.6e-03	0.014	0.001	0.009	NA	0.010	9.9e-03	0.27000	0.03100	NA	0.02600
6	TCGA	Brain Lower Grade Glioma	0.0472	0.0270	1.6e-03	0.010	0.026	0.016	NA	0.020	2.4e-02	0.00057	0.00490	NA	0.00190
7	TCGA	Lung Squamous Cell Carcinoma	0.1003	0.0529	2.2e-03	0.000	0.018	0.006	NA	0.006	3.2e-01	0.00340	0.05600	NA	0.06300

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.4	3.8	8.3	-2.1	-2.9	-1.3	-2.4	1.3	-1.7	-1.2
Bipolar Disorder or Schizophrenia	1.3	3.1	7.2	-2.0	-1.7	-1.4	-2.7	0.4	-1.6	-1.7
Depressed Affect (Nagel 2018)	0.8	1.8	4.1	1.1	-0.4	-1.5	-0.9	-2.0	-0.4	-1.9
Depression (Nagel 2018)	1.2	1.9	4.9	1.4	-1.3	-2.2	0.5	-1.8	0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.2	1.1	0.3	0.6	-1.1	0.3	0.0	-0.3
Neuroticism (Nagel 2018)	1.1	2.7	5.4	1.6	-2.0	-2.3	-1.3	-1.4	-0.2	-1.7
Schizophrenia (2018)	0.4	0.8	2.2	-0.9	0.1	-0.7	-1.5	-0.6	-0.7	-1.2
Schizophrenia vs Biploar Disorder	0.4	0.6	1.0	0.3	1.0	1.0	0.5	0.5	0.9	0.9
Worry (Nagel 2018)	0.7	1.6	3.7	1.4	-1.7	-1.9	-0.7	-1.0	-0.0	-1.0
Alzheimer’s Disease (in mother)	1.0	1.2	3.5	-0.6	1.7	0.9	1.9	0.2	-0.2	1.0
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.5	0.6	0.6	0.0	0.2	0.0	0.5
Alzheimer’s Disease (including proxy)	0.8	1.2	3.0	-0.8	1.7	1.1	1.6	0.4	-0.2	0.9
Crohns Disease (2017)	0.1	0.2	0.5	-0.7	-0.5	-0.4	-0.0	0.5	-0.5	-0.1
Irritable Bowel Disease (IBD)	0.2	0.4	0.9	-0.9	-1.0	-0.6	-0.5	0.4	-0.5	-0.4
Ulcerative Colitis (UC)	0.3	0.5	1.4	-1.2	-0.9	-0.5	-0.6	0.2	-0.5	-0.5
Major Depression (MDD)	0.8	1.0	2.5	1.2	1.3	-0.2	1.6	-0.5	0.8	0.5
Reaction Time	0.8	1.4	2.5	-1.4	1.1	1.5	-1.1	1.6	-1.1	0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.1	0.4	-0.1	-0.0	-1.4	0.3	-0.7	-0.8
Breast Cancer	1.5	3.5	8.8	2.0	2.6	1.7	3.0	0.2	0.1	1.5
Ovarian Cancer	0.2	0.3	1.1	-0.7	0.4	0.2	1.0	0.3	-0.3	0.6
Prostate Cancer	4.5	6.4	12.2	1.9	0.3	-3.0	-0.9	-3.0	-3.1	-3.5
Age at First Birth	0.3	0.5	1.7	0.3	-0.6	-0.6	0.1	0.9	-1.3	0.1
Bipolar Disorder (2011)	0.3	0.3	1.1	0.1	0.2	-0.4	-0.2	-0.2	-1.0	-0.9
Body Mass Index (BMI) (2010)	0.7	0.9	2.0	0.0	0.5	0.7	1.4	-0.1	1.4	1.3
Coronary Artery Disease (CAD)	1.8	2.1	4.4	-0.6	-1.9	-1.9	-0.5	0.2	-2.1	-1.7
Crohns Disease (2012)	0.5	0.9	2.7	-1.4	-0.5	0.9	-0.6	1.6	0.0	0.4
Mean Putamen Volume	0.4	0.4	1.1	0.4	1.0	0.1	0.3	-1.0	0.2	-0.7
Fasting Glucose	1.2	1.5	3.3	1.8	1.5	0.3	1.1	-1.5	1.1	0.4
HbA1C	0.6	0.7	3.1	-0.2	-1.8	-0.3	-0.2	0.4	1.0	0.5
HDL Cholesterol	0.7	1.2	3.4	-0.4	0.9	1.9	0.7	1.4	0.7	1.2
LDL Cholesterol	0.6	0.9	2.5	1.6	1.0	0.3	1.4	-0.6	-0.4	0.2
Lupus	0.5	0.8	2.7	-0.0	-1.4	-0.5	-1.6	0.3	0.0	-0.8
Neuroticism (2016)	1.9	2.8	10.2	1.3	-0.4	-2.2	0.2	-3.2	0.0	-1.6
Primary Biliary Cirrhosis	1.3	1.8	5.5	-1.3	-0.4	-0.7	-2.4	0.1	-1.4	-1.8
Rheumatoid Arthritis	0.9	1.2	3.8	1.2	-0.7	-1.2	0.3	-2.0	0.9	-0.3
Schizophrenia (2014)	0.4	0.8	1.7	-0.8	0.6	-0.5	-1.3	-0.5	-1.0	-1.1
Triglycerides	0.2	0.3	1.3	-0.2	0.5	0.2	1.1	0.3	-0.2	0.3
Type 2 Diabetes (T2D) (2012)	1.3	1.4	5.4	1.2	0.3	-1.0	0.9	-2.3	1.2	-0.1
Ulcerative Colitis	0.8	1.2	2.7	-1.4	-1.1	0.5	-1.2	1.6	-0.6	-0.2
Blood Eosinophil Count	0.3	2.7	6.9	0.9	-0.3	-1.3	-1.6	-0.9	-2.4	-2.6
Blood Platelet Count	0.5	5.5	13.2	-1.7	-3.6	-2.5	-3.1	0.4	-1.7	-1.9
Blood Red Count	0.5	5.2	7.4	2.7	2.0	2.4	2.5	0.4	2.5	2.6
Blood White Count	0.1	0.8	2.5	1.4	-0.6	-0.0	0.5	-0.7	1.6	0.0
Heel T-Score	0.1	0.7	3.0	-1.7	-0.4	0.4	-0.6	0.9	-0.5	0.2
BMI	0.1	0.6	1.7	1.3	0.2	-0.0	1.2	-0.7	0.5	0.2
Height	0.1	2.6	5.1	1.3	1.6	2.3	1.4	1.2	1.1	2.0
Waist Hip Ratio (WHR)	0.1	0.3	1.0	-1.0	0.3	0.3	0.5	0.6	-0.4	0.4
Systolic Blood Pressure	2.9	14.7	37.6	-2.5	-4.7	-2.7	-6.1	1.9	-3.6	-3.6
Smoking Status	0.7	1.6	3.6	-1.3	-1.0	-1.3	-1.3	-0.8	-1.0	-1.9
Allergy or Eczema	0.6	1.5	6.4	-0.5	-0.8	-0.9	-0.9	1.0	-2.5	-0.7
Cardiovascular Disease	0.4	1.3	2.8	0.1	-1.7	-1.5	-0.8	-0.6	-0.8	-1.5
Hypothyroidism (self reported)	0.5	1.1	3.5	0.5	1.1	0.3	1.9	-1.1	1.1	0.5
Respiratory disease	1.5	3.3	8.1	-2.8	-1.9	-0.7	-2.0	1.9	-1.6	-0.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.1	-1.4	-0.1	-1.1	1.4	-0.3	-0.7	-0.6
Lung FEV1/FVC ratio	0.5	2.6	5.5	2.0	-2.3	-1.0	1.1	-1.1	2.2	0.8
Lung FVC	0.2	0.8	3.6	1.2	-0.5	0.1	-1.9	0.4	-0.1	-0.2
Neuroticism	1.2	2.8	6.5	1.4	-1.9	-2.5	-1.1	-1.5	-1.1	-1.8
Chronotype (morning person)	0.6	1.4	4.3	-1.4	-0.4	0.6	-1.2	2.1	-1.2	0.1
Hair Pigment	0.0	1.1	4.3	-2.1	-0.7	-0.3	0.7	1.1	-1.1	0.3
Tanning	0.1	0.8	2.5	-0.3	0.4	-0.3	-1.5	-0.7	-0.6	-1.6
Hand grip strength (left)	0.1	0.2	0.5	0.0	0.6	-0.2	-0.6	-0.0	-0.7	-0.4
Number of treatments/medications taken	0.3	0.5	1.4	-1.2	-0.6	-0.8	0.9	-0.7	0.0	-0.2
Average weekly spirits intake	0.2	0.2	0.5	0.4	-0.3	-0.1	0.5	0.1	0.7	0.6
Sensitivity / hurt feelings	0.5	0.9	4.0	2.0	-0.6	-0.9	0.1	-0.9	0.5	-0.4
Frequency of depressed mood in last 2 weeks	2.1	2.9	7.5	0.1	-2.0	-2.7	0.0	-2.3	-0.3	-1.9
Hearing difficulty/problems: Yes	0.9	1.4	4.8	-0.3	1.7	0.5	2.2	0.3	-0.3	1.2
Relative age of first facial hair	0.1	0.3	0.6	-0.5	-0.4	0.4	-0.6	0.8	0.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.8	-0.4	-0.7	0.2	1.4	0.7	0.7	1.1
Ever used hormone-replacement therapy (HRT)	1.7	2.2	5.5	-0.3	-0.5	1.6	1.1	1.6	1.7	2.3
Ever had hysterectomy (womb removed)	1.3	1.5	3.9	-1.4	-2.0	-0.3	-1.0	1.6	-0.8	0.1
Systolic blood pressure, automated reading	0.8	2.4	5.4	-1.1	-2.3	-0.2	-2.3	2.0	-0.9	-0.4
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.2	-0.8	-1.0	-0.8	-1.8	0.4	-0.6	-0.8
Angina	3.9	5.1	13.7	-2.8	-3.7	-2.1	-2.3	0.9	-1.2	-1.4
Medication for hormone replacement therapy	0.6	0.6	1.9	-0.6	0.1	0.6	1.4	-0.1	1.1	0.9
Vitamin and mineral supplements	0.2	0.3	0.8	0.7	0.7	0.1	0.9	-0.4	0.3	0.5
Supplements: Zinc	1.7	1.9	4.7	-0.8	-0.2	1.8	0.3	2.2	0.9	1.9
Medication: Co-codamol	1.0	1.2	6.1	-2.5	-0.1	-0.1	1.3	-0.5	0.4	0.1
Medication: Metformin	1.0	1.3	2.8	1.4	0.6	-1.2	1.1	-1.7	-0.7	-1.1
Diabetes (father)	1.0	1.2	2.7	0.9	-0.1	-1.5	-1.0	-1.1	-0.8	-1.6
Diabetes (mother)	0.8	1.0	2.1	0.8	0.9	1.3	1.0	1.5	0.3	0.9
Severe depression (siblings)	0.1	0.1	0.4	0.1	-0.2	-0.6	-0.2	-0.4	0.3	-0.3
Pack years adult smoking proportion	1.5	2.2	5.4	-0.8	-2.1	-2.3	0.1	-0.2	-1.8	-1.3
Impedance of leg (right)	0.1	0.7	2.8	-1.7	-0.1	0.3	0.6	1.1	-0.5	0.5
Leg fat-free mass (left)	0.2	1.1	4.2	2.0	-0.1	-0.8	-0.5	-1.3	-0.1	-0.9
Trunk fat percentage	0.2	0.8	3.0	1.7	-0.0	-0.1	0.9	-0.9	0.8	0.3
Hand grip strength (right)	0.4	1.0	2.7	-0.2	-0.5	-0.8	-1.4	0.7	-1.6	-1.1
Townsend deprivation index at recruitment	0.6	0.8	3.5	-0.6	-1.9	-0.5	-0.7	0.4	0.8	0.3
Current tobacco smoking	1.2	2.0	4.1	0.7	-2.0	-1.9	-0.8	-1.4	-0.2	-1.7
Average weekly fortified wine intake	2.8	3.3	8.5	1.5	-2.1	-1.8	-2.9	-1.4	0.2	-1.6
Maternal smoking around birth	0.4	0.6	2.0	0.1	-0.7	0.7	-0.1	1.4	0.7	0.9
Fed-up feelings	1.0	1.8	4.1	1.3	-1.1	-1.9	-0.3	-2.0	-0.3	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.4	0.4	-1.6	-1.9	0.1	-1.0	0.3	-0.9
Relative age voice broke	1.0	1.5	4.4	-0.6	-0.5	0.8	1.3	1.1	1.4	2.1
Taking other prescription medications	0.7	1.1	3.6	-1.9	0.3	0.6	1.5	0.7	0.5	0.8
Age when periods started (menarche)	0.4	1.0	3.4	-0.8	1.0	1.8	-0.7	1.0	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.4	-0.2	-1.8	-0.7	-0.6	-0.1	0.6	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	-0.9	-0.2	0.2	0.7	0.3	0.6	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.8	-0.1	0.5	-0.1	0.5	0.4	-0.9	0.1
Qualifications: CSEs or equivalent	0.4	0.5	1.5	0.5	0.3	-0.9	1.2	-0.9	-0.0	-0.6
Serious illness, injury or assault to yourself	1.3	1.5	5.9	-1.6	0.4	-0.3	-0.0	1.3	-2.4	-0.5
High blood pressure	0.5	1.3	3.6	0.2	-1.9	-1.4	-1.4	-0.1	-0.5	-1.2
Hayfever, allergic rhinitis or eczema	1.2	2.6	9.6	-0.4	-1.2	-1.5	-1.4	0.7	-3.1	-1.5
Multivitamins +/- minerals	0.2	0.3	0.5	-0.3	-0.7	-0.3	-0.7	0.7	-0.7	-0.4
Stomach or abdominal pain in last month	1.8	2.3	5.7	-0.9	0.0	1.2	1.8	1.1	1.9	2.4
Supplements: Glucosamine	0.4	0.5	2.2	0.0	1.5	0.7	0.6	0.1	-0.6	-0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	3.1	-0.7	-1.8	-1.3	-0.1	0.1	-0.2	-0.1
Medication: Atenolol	1.0	1.3	2.4	-0.6	-0.8	-1.2	-1.0	-0.9	-1.6	-1.4
Medication: Levothyroxine sodium	0.1	0.2	0.6	-0.5	0.2	0.1	0.8	-0.3	0.4	0.1
Sitting height	0.2	1.6	3.3	1.8	1.8	0.1	1.6	-1.6	0.1	0.0
Chronic bronchitis/emphysema (father)	0.8	0.9	1.6	-0.3	1.1	1.0	1.2	-0.4	1.3	0.8
High blood pressure (mother)	1.2	1.6	3.6	0.8	-0.4	-1.9	-0.5	-1.4	-1.5	-1.6
Body mass index (BMI)	0.2	0.9	3.4	1.9	-0.1	-0.2	0.6	-1.0	1.1	0.3
Impedance of leg (left)	0.1	0.6	2.2	-1.5	0.1	0.2	1.1	0.6	-0.4	0.5
Leg predicted mass (left)	0.2	1.1	4.2	2.0	-0.1	-0.8	-0.5	-1.3	-0.1	-0.9
Trunk fat mass	0.2	1.0	4.3	2.1	0.1	-0.3	0.9	-1.2	0.6	0.1
Waist circumference	0.1	0.3	1.0	1.0	-0.4	-0.5	0.7	-0.5	0.3	0.1
Number of incorrect matches in round	0.2	0.3	0.6	0.5	-0.6	-0.5	-0.6	-0.5	-0.1	-0.8
Past tobacco smoking	1.0	1.9	7.0	2.6	-0.1	-0.4	1.1	-1.5	1.5	0.6
Alcohol usually taken with meals	2.0	3.2	7.1	2.2	2.6	0.5	2.7	-1.1	0.3	1.4
Nervous feelings	0.6	1.1	2.4	1.6	-0.3	-1.2	1.0	-1.5	0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.0	-0.1	-0.8	-0.8	1.4	-0.6	1.1	0.8
Hearing difficulty/problems with background noise	0.2	0.4	1.5	-0.8	0.2	-0.1	1.2	0.4	-0.1	0.5
Hair/balding pattern: Pattern 2	0.4	0.4	1.0	0.5	0.5	0.8	0.6	0.8	0.2	1.0
Had menopause	0.6	0.7	1.4	-0.9	-0.7	0.9	0.5	1.2	0.8	0.9
Had other major operations	0.6	0.8	3.2	-1.1	-1.8	-0.3	-0.6	0.6	-0.1	-0.1
Forced vital capacity (FVC)	0.2	0.7	3.3	0.5	-0.4	-0.4	-1.8	0.2	-0.8	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.4	0.1	0.6	0.4	0.2	0.9	0.8
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	14.6	1.2	0.0	0.6	1.4	-1.3	3.8	1.5
Qualifications: None of the above	0.8	1.7	4.8	-2.2	-0.3	1.4	0.4	1.4	1.3	1.2
Financial difficulties in last 2 years	5.3	7.1	14.1	-1.7	-3.6	-3.8	-2.4	-1.3	-2.0	-2.9
Mouth/teeth dental problems	1.6	2.4	8.2	2.9	-0.8	-1.5	-0.7	-2.0	0.1	-0.9
Heart attack	0.6	0.8	2.8	-1.2	-1.7	-0.6	-0.5	0.7	-0.3	-0.1
Allergy	1.5	3.4	6.1	0.4	2.5	2.1	2.1	-0.5	2.3	1.7
Pain all over the body in last month	3.3	3.6	5.6	-1.9	-2.2	-2.1	-1.8	-0.4	-1.8	-2.4
Diabetes (self-reported)	0.3	0.4	1.3	-0.3	-0.4	-1.1	0.8	-0.3	-0.6	-0.6
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.1	-1.2	-1.2	-0.8	-1.5	0.9	-1.8	-1.3
Medication: Ramipril	0.9	1.1	2.8	-1.0	-1.7	-1.3	-0.8	0.3	-0.9	-0.8
Medication: Simvastatin	0.2	0.2	0.6	-0.6	-0.5	-0.0	-0.7	0.0	0.6	0.1
Fluid intelligence score	0.6	1.2	1.9	1.0	-0.5	-1.3	-0.9	-1.3	-0.8	-1.4
Illnesses of siblings	2.0	2.7	6.2	-0.7	-1.2	-1.4	-2.5	-0.6	-2.0	-2.1
Neuroticism score	1.5	3.1	7.1	1.5	-2.4	-2.7	-1.2	-1.4	-0.3	-1.6
Weight	0.2	1.0	4.7	2.2	-0.1	-0.4	0.7	-1.1	0.7	0.2
Impedance of arm (right)	0.1	0.6	1.5	-0.8	-0.2	-0.4	-1.0	0.3	-1.2	-0.8
Arm fat percentage (right)	0.2	0.7	3.8	2.0	-0.2	-0.4	0.2	-0.9	0.4	-0.1
Trunk fat-free mass	0.1	0.7	3.4	1.8	0.6	-0.2	0.3	-0.9	0.0	-0.1
Hip circumference	0.4	1.6	5.9	2.4	0.2	-0.9	1.0	-1.7	0.2	-0.5
Time employed in main current job	1.2	1.4	3.9	2.0	1.9	0.6	0.8	-1.1	0.6	0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.3	-0.7	-0.7	-0.7	0.5	-1.1	1.0	-0.5
Father’s age at death	1.0	1.4	3.8	-0.7	0.6	1.3	-1.9	1.4	-1.1	0.1
Worrier / anxious feelings	0.9	1.8	4.1	1.1	-0.8	-2.0	-0.4	-1.0	-1.6	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	6.2	0.4	-2.5	-1.7	-0.0	-0.1	0.5	-0.3
Falls in the last year	0.8	1.1	5.0	-0.5	-2.2	-1.2	-0.3	-0.8	0.8	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.2	0.1	-0.7	-0.1	-0.4	-0.7	-0.2
Number of live births	1.1	1.5	3.7	-1.2	0.6	1.0	1.1	0.1	1.9	1.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.9	0.9	-0.4	0.0	-1.0	0.2	0.2	0.2
Pulse rate	1.3	2.1	5.6	2.2	-0.0	-1.5	1.4	-2.4	0.6	-0.4
Happiness	0.9	1.1	4.1	-0.4	-1.3	-0.1	-2.0	1.0	-0.5	-0.7
Noisy workplace	0.9	1.2	3.0	-1.3	-1.0	0.2	-1.5	1.7	-0.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.7	0.1	0.2	-0.3	0.5	0.4	0.8
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	6.6	-0.7	-2.3	-2.6	-1.0	-0.3	-2.3	-1.9
Mouth/teeth dental problems: Dentures	2.2	3.6	6.0	-0.7	2.0	2.5	2.4	0.9	1.9	2.2
Asthma	2.4	4.8	10.2	-3.2	-3.0	-2.0	-2.3	1.1	-1.5	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.8	1.2	-0.1	-0.1	1.3	-1.3	1.3	0.7
Medication: Cholesterol lowering	0.3	0.4	1.8	0.8	-0.2	0.3	-0.1	-0.4	1.3	0.5
Depression (self-reported)	0.8	1.0	3.6	0.5	0.6	0.7	1.2	-0.6	1.9	0.6
Medication: Lansoprazole	2.8	3.2	6.6	-1.3	1.1	1.8	2.6	2.4	-0.1	1.9
Prospective memory result	0.3	0.4	1.0	-0.7	0.0	0.7	0.2	1.0	0.5	0.8
Lung cancer (father)	0.8	0.9	2.4	-1.5	0.3	0.9	0.2	1.5	-0.3	0.9
Illnesses of mother	0.7	0.8	1.8	-0.6	-0.9	1.0	-0.8	0.8	1.4	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.7	0.9	-0.8	-0.7	-1.7	0.2	-1.0	-0.6
Pulse wave Arterial Stiffness index	0.7	0.8	2.6	0.1	-1.6	-0.2	0.4	0.2	1.6	0.7
Impedance of arm (left)	0.1	0.3	1.0	-0.9	-0.1	-0.1	-0.1	0.7	-1.0	-0.3
Arm fat mass (right)	0.2	0.8	4.5	2.1	-0.0	-0.3	0.6	-0.9	0.3	-0.0
Trunk predicted mass	0.1	0.7	3.4	1.8	0.6	-0.3	0.3	-0.9	-0.1	-0.2
Standing height	0.0	0.3	1.3	1.1	0.6	0.1	0.6	-0.2	-0.5	0.0
Length of working week for main job	0.8	0.8	2.5	-1.6	-0.4	1.1	-0.6	1.0	0.6	0.6
Exposure to tobacco smoke at home	0.7	0.8	2.1	0.3	0.2	-1.0	0.7	-1.4	-0.9	-1.1
Breastfed as a baby	0.5	0.6	1.3	1.1	-1.1	0.0	-1.1	0.6	0.2	0.0
Tense / ‘highly strung’	1.2	1.9	4.0	-0.0	-2.0	-2.0	-1.2	-0.7	-1.0	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.2	-1.2	-2.0	-1.1	-0.2	-0.4	1.6	-0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.4	-1.2	1.1	0.2	0.7	-0.6	-0.1	-0.3
Birth weight of first child	0.4	0.8	2.8	-0.5	0.4	-0.3	-1.7	-1.1	-0.2	-1.1
Peak expiratory flow (PEF)	0.2	0.5	1.4	0.6	-0.4	0.5	0.3	0.4	1.2	1.1
Pulse wave reflection index	0.6	0.7	1.7	-0.9	-0.7	0.6	-0.3	1.3	0.7	0.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.7	0.8	-1.3	-1.6	0.1	-1.4	0.4	-0.5
Loud music exposure frequency	1.5	1.7	3.2	0.8	-0.9	-1.7	-0.8	-1.6	-0.8	-1.8
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.1	1.2	-1.2	-1.9	-2.0	-1.0	-1.6	-1.8
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.0	-1.7	-0.8	-0.4	-1.3	0.9	-1.2	-0.8
Blood clot in the leg (DVT)	5.2	6.8	25.2	5.0	-1.6	-1.1	-0.7	-2.8	3.2	-0.4
Medication: Paracetamol	0.9	1.5	4.9	0.8	-1.0	-1.7	0.4	-2.2	0.6	-0.8
Headache pain in last month	0.3	0.5	1.3	0.2	0.6	0.6	1.1	0.3	0.2	1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.0	-1.1	0.4	0.1	-0.2	0.8	-1.4	-0.3
Glaucoma (self-reported)	0.7	0.9	1.5	-0.2	-1.1	-1.1	-1.0	-0.2	-1.0	-1.2
Gout (self-reported)	2.1	2.9	4.9	1.6	1.9	0.9	2.2	-1.8	2.2	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.6	-0.6	0.6	0.2	1.2	-0.5	0.8	0.4
Medication: Amlodipine	0.9	1.2	2.7	-1.6	-0.8	0.8	0.2	1.2	1.4	1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	6.0	-2.5	-1.3	-0.4	0.0	1.2	0.1	0.1
Birth weight	0.8	1.6	3.5	-1.6	0.7	1.0	0.9	1.9	-1.7	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.8	-0.1	0.9	0.3	0.5	0.1	0.1	0.9
High blood pressure (siblings)	2.1	3.0	6.0	0.1	0.4	1.9	1.7	1.8	2.2	2.5
Forced vital capacity (FVC), Best measure	0.3	1.0	2.9	0.6	-0.2	-0.6	-1.7	0.4	-1.6	-0.8
Body fat percentage	0.2	0.8	3.1	1.8	-0.4	-0.5	0.9	-1.0	0.6	0.2
Leg fat percentage (right)	0.2	0.7	1.8	1.3	-0.4	-0.3	1.2	-0.6	0.7	0.6
Arm fat-free mass (right)	0.1	0.6	2.3	1.5	-0.5	-0.6	0.3	-0.9	0.4	-0.1
Exposure to tobacco smoke outside home	1.1	1.5	4.0	-2.0	-0.5	0.5	1.0	1.9	0.2	1.1
Comparative body size at age 10	0.4	1.0	3.1	1.8	0.1	0.2	-0.3	-0.9	1.8	-0.0
Number of full brothers	0.8	1.0	2.0	0.8	0.8	0.6	1.3	-0.2	1.2	1.4
Worry too long after embarrassment	0.9	1.5	2.7	1.6	-1.2	-1.6	-1.3	-0.7	-0.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.5	-0.5	-1.2	-1.2	0.7	-1.1	1.1	-0.3
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	-1.0	-1.1	-0.8	0.9	0.2	-0.4	-0.0
Number of children fathered	0.7	0.8	1.4	0.9	1.2	0.7	0.8	0.8	0.1	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.6	0.5	-0.2	-0.1	-0.5	0.2	-0.8	0.0
Age at first live birth	0.4	0.6	3.2	0.1	1.8	0.9	0.2	-0.0	-0.6	0.2
Pulse wave peak to peak time	0.9	1.0	3.5	-0.1	1.5	0.2	-0.6	0.0	-1.9	-0.9
Health satisfaction	0.3	0.4	1.8	-0.1	-1.4	-0.4	-0.3	0.3	0.5	-0.1
Shortness of breath walking on level ground	0.9	1.0	4.8	0.1	-2.2	-1.2	-0.6	0.2	0.7	-0.2
Qualifications: College or University degree	0.2	0.7	2.2	1.5	1.3	0.2	-0.3	-0.5	-0.6	0.2
Eye problems/disorders: None of the above	0.1	0.2	0.5	0.2	0.2	0.5	0.5	0.2	0.1	0.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.0	-1.0	-1.7	-1.5	-0.2	-0.4	-0.4	-0.9
Emphysema/chronic bronchitis	0.8	0.9	2.4	-1.6	-0.9	-0.3	1.0	0.7	0.5	0.9
Medication for pain relief, constipation, heartburn	0.7	1.2	3.1	-0.7	1.7	0.8	-0.5	1.0	-1.8	-0.4
Neck or shoulder pain in last month	0.7	1.0	2.2	0.6	-1.5	-1.4	-0.6	-1.0	1.0	-0.1
Medication: Blood pressure	0.3	0.6	1.8	0.5	-1.4	-0.9	-1.1	-0.2	0.2	-0.4
Angina (self-reported)	3.5	4.6	11.6	-3.0	-3.4	-1.9	-2.0	1.0	-1.3	-1.2
Migraine (self-reported)	1.2	1.4	4.9	0.9	-1.5	-0.8	-2.2	-0.2	-0.6	-1.0
Medication: Ibuprofen	0.7	0.9	3.3	0.9	-0.4	-1.1	0.6	-1.8	0.4	-0.4
Medication: Allopurinol	0.6	0.8	2.3	0.6	1.2	0.4	1.5	-1.1	0.7	0.1
Medication: Omeprazole	0.4	0.5	0.9	0.8	-0.3	-0.5	0.8	-0.8	1.0	0.4
Medication: Seretide 50 evohaler	0.7	0.8	1.9	-1.2	-1.1	0.4	-0.8	1.4	0.3	0.4
Mean time to correctly identify matches	1.0	2.0	4.7	-1.5	1.2	2.0	-0.4	2.2	-0.5	1.1
Heart disease (mother)	0.7	0.8	2.3	-0.7	-1.2	-1.5	-0.1	-0.6	-0.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	4.2	-1.4	-2.0	-1.3	-1.9	0.6	-2.0	-1.4
Whole body fat mass	0.3	1.1	4.6	2.1	-0.1	-0.4	0.9	-1.2	0.8	0.1
Leg fat mass (right)	0.2	0.9	3.4	1.8	-0.1	-0.3	1.1	-0.9	0.6	0.3
Arm predicted mass (right)	0.2	0.9	4.0	2.0	-0.4	-0.6	0.3	-1.1	0.4	-0.2
Pulse rate, automated reading	0.7	2.3	7.7	1.6	0.1	-1.8	1.3	-2.8	0.3	-1.0
Alcohol intake frequency.	0.4	0.8	2.9	0.1	-1.7	-1.0	-0.5	-0.4	1.2	-0.4
Comparative height size at age 10	0.2	1.4	2.8	1.7	-0.9	-1.3	-0.6	-0.2	-1.7	-1.0
Number of full sisters	0.6	0.8	2.2	-0.7	-0.9	-1.5	0.4	-0.9	-0.5	-0.9
Suffer from ‘nerves’	0.9	1.4	4.4	2.1	-1.3	-0.8	0.7	-0.5	1.5	0.8
Overall health rating	1.0	2.2	6.7	-0.3	-2.4	-2.6	-0.0	-1.4	-0.4	-1.1
Chest pain or discomfort	0.9	1.4	4.9	-1.2	-2.2	-1.2	-0.8	-0.1	-0.4	-0.9
Had major operations	0.9	1.1	2.5	-1.6	0.3	0.8	1.2	0.2	1.3	1.1
Age at last live birth	0.2	0.3	1.4	-0.1	1.2	0.6	-0.2	-0.3	-0.3	0.1
Family relationship satisfaction	1.4	1.8	6.1	-1.2	-2.5	-0.7	-1.5	1.4	-0.5	-0.3
Leg pain on walking	4.1	5.1	13.0	0.3	-2.7	-3.6	-1.3	-2.4	-0.9	-2.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.2	0.3	-0.2	0.3	0.5	1.1	-0.5	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.0	1.0	0.3	-0.4	-0.7	-0.1	-0.3	0.0
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	7.3	1.3	1.1	1.5	0.3	-0.4	2.7	1.4
Medication: Aspirin	2.4	3.2	12.2	0.4	-3.5	-2.1	-1.9	-0.2	-0.3	-1.4
Supplements: Vitamin C	0.6	0.7	2.3	-0.8	-0.7	-0.3	-1.5	0.1	-0.7	-0.9
Knee pain experienced in last month	0.7	1.2	3.8	1.1	0.5	-0.4	1.0	-1.9	1.3	0.1
Hypertension (Self-reported)	0.5	1.5	4.3	0.2	-2.1	-1.6	-1.4	-0.2	-0.5	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.4	0.6	0.9	0.7	1.6	-0.6	1.4	0.9
Illnesses of father: Heart disease	0.3	0.5	2.3	-1.5	-0.5	-0.2	-0.5	0.7	-0.1	-0.2
Illnesses of siblings: Diabetes	1.2	1.5	4.4	0.9	1.8	1.1	2.1	0.2	0.1	0.8
Smoking status: Previous	1.1	1.6	5.2	-2.3	0.9	1.0	-0.7	1.7	-0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.1	-1.4	0.0	-0.4	-0.4	0.8	-1.8	-0.7
Whole body fat-free mass	0.1	0.8	4.1	2.0	0.2	-0.5	-0.1	-1.1	-0.1	-0.5
Leg fat-free mass (right)	0.2	1.2	4.2	2.1	0.2	-0.8	-0.2	-1.5	-0.2	-0.9
Arm fat percentage (left)	0.2	0.7	3.5	1.9	-0.3	-0.4	0.6	-0.8	0.4	0.1
Average weekly red wine intake	1.4	2.1	9.7	3.1	1.0	-0.8	-0.6	-1.6	-0.2	-0.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.8	0.3	1.7	0.7	1.2	-0.2	-0.3	0.5
Mood swings	0.6	1.1	3.1	0.6	-0.6	-1.3	-0.7	-1.8	0.4	-1.2
Loneliness, isolation	0.6	0.8	1.7	-0.1	-1.1	-1.1	-0.6	-1.3	0.3	-0.9
Long-standing illness, disability or infirmity	1.3	1.9	6.9	-2.6	-1.5	-1.3	1.2	0.5	-0.9	0.1
Ever had bowel cancer screening	1.8	2.1	4.0	-2.0	1.4	1.7	1.4	1.4	0.2	1.4
Diabetes diagnosed by doctor	0.3	0.5	1.1	-0.8	-0.3	-1.1	1.0	-0.1	-0.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.3	-1.5	-1.2	-0.2	-1.0	1.1	-1.0	-0.5
Friendships satisfaction	1.7	2.1	4.7	-0.9	-2.2	-1.7	-1.6	0.2	-1.5	-1.4
Qualifications: nursing, teaching	0.4	0.7	1.2	1.0	0.2	-1.1	-0.8	-0.7	-1.1	-0.6
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.7	-0.0	0.1	0.2	-0.4	0.3	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.5	-0.3	-0.1	-0.3	0.0	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.2	-1.7	-0.7	-0.1	-0.7	1.8	-1.4	-0.1
Medication for cholesterol	0.4	0.5	2.1	1.4	1.0	0.5	-0.6	0.1	-0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.8	5.0	-0.3	1.7	2.2	0.7	1.7	0.4	1.2
Back pain experienced in last month	0.4	0.6	1.5	-0.8	-0.8	-0.4	1.2	0.6	0.6	0.5
Mineral and other dietary supplements	1.1	1.4	3.5	0.3	-1.6	-1.9	-0.9	-1.4	0.4	-1.0
Breast cancer (self-reported)	2.8	3.4	5.9	1.6	-1.8	-2.4	-1.5	-1.5	-1.2	-2.4
Asthma (self-reported)	2.4	4.7	8.8	-2.9	-3.0	-2.0	-2.4	1.0	-1.6	-1.6
Osteoporosis (self-reported)	1.3	1.6	7.2	-2.7	0.0	0.8	1.1	0.8	0.5	1.0
Osteoarthritis (self-reported)	0.7	0.9	3.2	-1.8	-1.3	-0.4	0.3	-0.2	1.1	-0.1
Medication: Aspirin	2.2	2.9	11.2	-0.4	-3.3	-1.7	-1.8	0.6	-0.8	-1.3
Medication: Gliclazide	0.4	0.4	0.9	-0.8	-0.8	-0.6	-0.4	0.1	-0.6	-1.0
Illnesses of father: None of the above (group 1)	1.6	1.9	3.7	-0.3	0.4	1.8	1.4	1.9	0.9	1.9
Smoking status: Current	1.5	2.4	4.9	0.6	-2.2	-2.2	-0.9	-1.7	-0.3	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.1	0.9	-0.7	0.4	-0.8	-0.0	1.4	0.7
Whole body water mass	0.2	0.9	3.8	2.0	0.1	-0.7	-0.1	-1.3	-0.0	-0.6
Leg predicted mass (right)	0.2	1.2	4.3	2.1	0.1	-0.9	-0.3	-1.5	-0.2	-1.0
Arm fat mass (left)	0.2	0.9	4.6	2.1	0.1	-0.2	0.8	-0.9	0.6	0.2
Number of self-reported non-cancer illnesses	3.0	5.2	16.2	-3.0	-4.0	-1.9	-2.0	1.3	-0.6	-1.3
Average weekly champagne plus white wine intake	0.6	0.8	2.9	-0.7	0.3	0.8	-0.4	1.7	-0.3	1.1
Miserableness	0.8	1.3	2.2	0.9	-0.9	-1.5	-1.2	-1.3	-0.5	-1.4
Guilty feelings	0.7	1.0	4.6	0.2	-2.1	-1.3	-0.5	0.3	0.3	-0.2
Wears glasses or contact lenses	0.7	0.8	1.4	1.2	0.9	0.2	1.1	-1.1	0.9	0.4
Ever taken oral contraceptive pill	0.8	0.9	1.8	0.6	1.4	-0.3	0.3	-0.9	-1.2	-1.3
Hearing aid user	0.4	0.5	2.5	-0.1	-1.6	-0.7	0.1	0.7	-0.2	0.1
Mother’s age at death	1.5	1.8	4.4	2.1	2.1	1.4	1.3	-0.1	-0.2	0.7
Financial situation satisfaction	1.2	1.5	3.2	-1.0	-1.1	-1.3	-1.0	-0.0	-1.8	-1.7
Tinnitus: Yes, now most or all of the time	3.1	3.6	7.0	-1.6	-1.6	-1.3	-2.6	0.6	-2.5	-2.1
Commuting to job workplace: Public transport	0.3	0.4	1.3	1.1	-0.9	-0.2	-0.1	-0.4	0.4	-0.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.6	0.1	-0.4	-1.1	-0.6	-1.0	-0.5	-1.3
Medication: Blood pressure	1.1	2.0	3.8	-0.4	-1.9	-1.9	-0.9	-0.1	-1.7	-1.7
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.2	-1.1	-0.5	0.7	0.8	1.8	0.4	1.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	2.0	0.3	0.6	0.2	-0.2	0.4	-1.4	-0.4
High cholesterol (Self-reported)	0.4	0.6	1.9	-0.8	-0.6	0.5	0.2	1.4	0.4	1.1
Medication: Bendroflumethiazide	1.4	2.1	3.4	1.7	-0.5	-1.3	-1.7	-1.2	-1.3	-1.8
Medication: Paracetamol	1.3	2.0	5.7	0.7	-1.1	-2.1	0.3	-2.4	-0.2	-1.2
Medication: Lisinopril	0.6	0.8	2.1	-0.3	-1.4	-0.4	-1.4	-0.2	0.5	-0.8
Medication: Atorvastatin	1.9	2.3	5.2	-1.0	-0.5	0.8	2.3	2.3	0.0	2.0
Illnesses of father: High blood pressure	3.6	4.5	8.1	1.0	-2.5	-2.9	-2.2	-2.3	-0.7	-2.3
Alcohol drinker status: Never	1.1	1.3	2.5	0.7	-1.3	-1.6	-1.4	-0.8	-0.7	-1.2
Ever smoked	0.4	0.8	2.2	-1.5	0.6	0.1	-0.2	0.3	-1.4	-0.8
Basal metabolic rate	0.1	0.8	3.9	2.0	0.2	-0.5	0.1	-1.1	0.1	-0.4
Leg fat percentage (left)	0.3	0.9	2.2	1.5	-0.3	-0.3	1.5	-0.9	0.9	0.7
Arm fat-free mass (left)	0.1	0.6	2.6	1.6	-0.2	-0.6	-0.0	-1.1	0.2	-0.4
Number of operations (self-reported)	1.8	2.7	8.8	-3.0	-1.8	0.8	-0.2	2.0	0.9	1.1
Average weekly beer plus cider intake	0.6	0.9	3.9	-2.0	-1.1	0.3	-0.4	0.9	-0.0	-0.3
Irritability	1.5	2.5	4.0	2.0	-1.7	-1.9	-1.5	-1.7	0.2	-1.3
Risk taking	1.0	1.5	5.6	-0.0	-0.4	1.1	0.4	0.4	2.4	1.8
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.4	-0.3	-1.4	-1.9	-1.1	-1.0	-1.4	-1.5
Fractured/broken bones in last 5 years	0.1	0.2	0.5	-0.3	-0.2	-0.4	-0.3	0.2	-0.7	-0.5
Age started oral contraceptive pill	0.2	0.2	0.4	-0.5	0.3	0.6	-0.1	0.6	-0.2	0.4
Diastolic blood pressure, automated reading	0.4	1.3	4.5	0.7	2.1	1.0	1.0	-1.0	0.6	0.7
Ever depressed for a whole week	1.4	1.7	9.4	-0.3	0.3	0.9	0.4	-0.8	3.1	0.9
Unable to work because of sickness or disability	1.7	2.2	5.6	0.1	-1.7	-2.4	-0.1	-2.2	-0.2	-1.4
Commuting to job workplace: Cycle	0.6	0.7	1.8	1.4	-0.8	-0.7	-1.1	-0.4	-0.6	-0.6
Myopia	1.0	1.5	3.0	1.2	0.6	-0.7	-1.5	-0.6	-1.6	-1.7
Vascular/heart problems diagnosed by doctor	0.6	1.6	5.8	0.5	2.4	1.4	1.1	-0.5	0.7	1.0
Cholesterol lowering medication	0.9	1.4	2.7	-1.4	-0.7	0.8	0.7	1.6	0.9	1.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.0	0.8	-0.6	-1.0	0.3	-0.8	0.1	-0.4
Pain experienced in last month	0.5	0.8	2.0	0.7	0.1	-0.4	-1.1	-0.4	-1.4	-1.1
Supplements: Calcium	1.4	1.5	4.0	-2.0	-0.2	1.0	0.1	2.0	-1.1	0.6
Basal cell carcinoma (self-reported)	1.0	1.1	1.8	1.1	0.5	-1.1	0.9	-1.3	-1.2	-1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.2	-1.2	-1.8	-0.6	-0.6	0.8	-0.4	-0.1
Deep venous thrombosis (DVT) (self-reported)	6.0	7.7	29.0	5.4	-1.6	-1.2	-0.8	-3.0	3.3	-0.4
Heart disease (siblings)	1.0	1.2	4.4	-0.2	-0.2	0.7	1.1	-0.1	2.1	1.4
Alcohol drinker status: Previous	1.3	1.4	6.1	-0.8	-2.5	-1.1	-0.8	0.2	1.2	-0.0
Pack years of smoking	0.7	1.0	2.6	-0.5	-1.3	-1.6	0.5	-0.2	-1.1	-0.8
Impedance of whole body	0.1	0.5	2.0	-1.4	-0.2	0.0	0.4	0.8	-0.7	0.1
Leg fat mass (left)	0.3	1.2	4.5	2.1	-0.0	-0.3	1.3	-1.1	0.7	0.4
Arm predicted mass (left)	0.2	0.8	3.5	1.9	-0.1	-0.6	0.4	-1.2	0.4	-0.3