Hub : Genes

BLZF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0570 0.0250 9.8e-03 0.002 0.017 0.016 0.018 0.012 1.8e-01 0.00350 0.00370 0.0027 0.01100
2 TCGA Bladder Urothelial Carcinoma 0.1960 0.0790 2.1e-06 0.046 0.037 0.039 NA 0.041 8.4e-05 0.00040 0.00031 NA 0.00021
3 TCGA Breast Invasive Carcinoma 0.0687 0.0339 6.7e-04 0.000 0.008 0.008 NA 0.003 3.6e-01 0.00650 0.00580 NA 0.07700
4 TCGA Cervical Squamous Cell Carcinoma 0.2830 0.1120 2.8e-03 -0.005 -0.005 -0.005 NA -0.006 7.0e-01 0.72000 0.69000 NA 0.87000
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0976 0.0516 5.6e-03 0.014 0.001 0.009 NA 0.010 9.9e-03 0.27000 0.03100 NA 0.02600
6 TCGA Brain Lower Grade Glioma 0.0472 0.0270 1.6e-03 0.010 0.026 0.016 NA 0.020 2.4e-02 0.00057 0.00490 NA 0.00190
7 TCGA Lung Squamous Cell Carcinoma 0.1003 0.0529 2.2e-03 0.000 0.018 0.006 NA 0.006 3.2e-01 0.00340 0.05600 NA 0.06300

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 2.4 3.8 8.3 -2.1 -2.9 -1.3 -2.4 1.3 -1.7 -1.2
Bipolar Disorder or Schizophrenia 1.3 3.1 7.2 -2.0 -1.7 -1.4 -2.7 0.4 -1.6 -1.7
Depressed Affect (Nagel 2018) 0.8 1.8 4.1 1.1 -0.4 -1.5 -0.9 -2.0 -0.4 -1.9
Depression (Nagel 2018) 1.2 1.9 4.9 1.4 -1.3 -2.2 0.5 -1.8 0.1 -1.0
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.2 1.1 0.3 0.6 -1.1 0.3 0.0 -0.3
Neuroticism (Nagel 2018) 1.1 2.7 5.4 1.6 -2.0 -2.3 -1.3 -1.4 -0.2 -1.7
Schizophrenia (2018) 0.4 0.8 2.2 -0.9 0.1 -0.7 -1.5 -0.6 -0.7 -1.2
Schizophrenia vs Biploar Disorder 0.4 0.6 1.0 0.3 1.0 1.0 0.5 0.5 0.9 0.9
Worry (Nagel 2018) 0.7 1.6 3.7 1.4 -1.7 -1.9 -0.7 -1.0 -0.0 -1.0
Alzheimer’s Disease (in mother) 1.0 1.2 3.5 -0.6 1.7 0.9 1.9 0.2 -0.2 1.0
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.5 0.6 0.6 0.0 0.2 0.0 0.5
Alzheimer’s Disease (including proxy) 0.8 1.2 3.0 -0.8 1.7 1.1 1.6 0.4 -0.2 0.9
Crohns Disease (2017) 0.1 0.2 0.5 -0.7 -0.5 -0.4 -0.0 0.5 -0.5 -0.1
Irritable Bowel Disease (IBD) 0.2 0.4 0.9 -0.9 -1.0 -0.6 -0.5 0.4 -0.5 -0.4
Ulcerative Colitis (UC) 0.3 0.5 1.4 -1.2 -0.9 -0.5 -0.6 0.2 -0.5 -0.5
Major Depression (MDD) 0.8 1.0 2.5 1.2 1.3 -0.2 1.6 -0.5 0.8 0.5
Reaction Time 0.8 1.4 2.5 -1.4 1.1 1.5 -1.1 1.6 -1.1 0.0
Verbal and Numeric Reasoning (VNR) 0.2 0.5 2.1 0.4 -0.1 -0.0 -1.4 0.3 -0.7 -0.8
Breast Cancer 1.5 3.5 8.8 2.0 2.6 1.7 3.0 0.2 0.1 1.5
Ovarian Cancer 0.2 0.3 1.1 -0.7 0.4 0.2 1.0 0.3 -0.3 0.6
Prostate Cancer 4.5 6.4 12.2 1.9 0.3 -3.0 -0.9 -3.0 -3.1 -3.5
Age at First Birth 0.3 0.5 1.7 0.3 -0.6 -0.6 0.1 0.9 -1.3 0.1
Bipolar Disorder (2011) 0.3 0.3 1.1 0.1 0.2 -0.4 -0.2 -0.2 -1.0 -0.9
Body Mass Index (BMI) (2010) 0.7 0.9 2.0 0.0 0.5 0.7 1.4 -0.1 1.4 1.3
Coronary Artery Disease (CAD) 1.8 2.1 4.4 -0.6 -1.9 -1.9 -0.5 0.2 -2.1 -1.7
Crohns Disease (2012) 0.5 0.9 2.7 -1.4 -0.5 0.9 -0.6 1.6 0.0 0.4
Mean Putamen Volume 0.4 0.4 1.1 0.4 1.0 0.1 0.3 -1.0 0.2 -0.7
Fasting Glucose 1.2 1.5 3.3 1.8 1.5 0.3 1.1 -1.5 1.1 0.4
HbA1C 0.6 0.7 3.1 -0.2 -1.8 -0.3 -0.2 0.4 1.0 0.5
HDL Cholesterol 0.7 1.2 3.4 -0.4 0.9 1.9 0.7 1.4 0.7 1.2
LDL Cholesterol 0.6 0.9 2.5 1.6 1.0 0.3 1.4 -0.6 -0.4 0.2
Lupus 0.5 0.8 2.7 -0.0 -1.4 -0.5 -1.6 0.3 0.0 -0.8
Neuroticism (2016) 1.9 2.8 10.2 1.3 -0.4 -2.2 0.2 -3.2 0.0 -1.6
Primary Biliary Cirrhosis 1.3 1.8 5.5 -1.3 -0.4 -0.7 -2.4 0.1 -1.4 -1.8
Rheumatoid Arthritis 0.9 1.2 3.8 1.2 -0.7 -1.2 0.3 -2.0 0.9 -0.3
Schizophrenia (2014) 0.4 0.8 1.7 -0.8 0.6 -0.5 -1.3 -0.5 -1.0 -1.1
Triglycerides 0.2 0.3 1.3 -0.2 0.5 0.2 1.1 0.3 -0.2 0.3
Type 2 Diabetes (T2D) (2012) 1.3 1.4 5.4 1.2 0.3 -1.0 0.9 -2.3 1.2 -0.1
Ulcerative Colitis 0.8 1.2 2.7 -1.4 -1.1 0.5 -1.2 1.6 -0.6 -0.2
Blood Eosinophil Count 0.3 2.7 6.9 0.9 -0.3 -1.3 -1.6 -0.9 -2.4 -2.6
Blood Platelet Count 0.5 5.5 13.2 -1.7 -3.6 -2.5 -3.1 0.4 -1.7 -1.9
Blood Red Count 0.5 5.2 7.4 2.7 2.0 2.4 2.5 0.4 2.5 2.6
Blood White Count 0.1 0.8 2.5 1.4 -0.6 -0.0 0.5 -0.7 1.6 0.0
Heel T-Score 0.1 0.7 3.0 -1.7 -0.4 0.4 -0.6 0.9 -0.5 0.2
BMI 0.1 0.6 1.7 1.3 0.2 -0.0 1.2 -0.7 0.5 0.2
Height 0.1 2.6 5.1 1.3 1.6 2.3 1.4 1.2 1.1 2.0
Waist Hip Ratio (WHR) 0.1 0.3 1.0 -1.0 0.3 0.3 0.5 0.6 -0.4 0.4
Systolic Blood Pressure 2.9 14.7 37.6 -2.5 -4.7 -2.7 -6.1 1.9 -3.6 -3.6
Smoking Status 0.7 1.6 3.6 -1.3 -1.0 -1.3 -1.3 -0.8 -1.0 -1.9
Allergy or Eczema 0.6 1.5 6.4 -0.5 -0.8 -0.9 -0.9 1.0 -2.5 -0.7
Cardiovascular Disease 0.4 1.3 2.8 0.1 -1.7 -1.5 -0.8 -0.6 -0.8 -1.5
Hypothyroidism (self reported) 0.5 1.1 3.5 0.5 1.1 0.3 1.9 -1.1 1.1 0.5
Respiratory disease 1.5 3.3 8.1 -2.8 -1.9 -0.7 -2.0 1.9 -1.6 -0.5
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.1 -1.4 -0.1 -1.1 1.4 -0.3 -0.7 -0.6
Lung FEV1/FVC ratio 0.5 2.6 5.5 2.0 -2.3 -1.0 1.1 -1.1 2.2 0.8
Lung FVC 0.2 0.8 3.6 1.2 -0.5 0.1 -1.9 0.4 -0.1 -0.2
Neuroticism 1.2 2.8 6.5 1.4 -1.9 -2.5 -1.1 -1.5 -1.1 -1.8
Chronotype (morning person) 0.6 1.4 4.3 -1.4 -0.4 0.6 -1.2 2.1 -1.2 0.1
Hair Pigment 0.0 1.1 4.3 -2.1 -0.7 -0.3 0.7 1.1 -1.1 0.3
Tanning 0.1 0.8 2.5 -0.3 0.4 -0.3 -1.5 -0.7 -0.6 -1.6
Hand grip strength (left) 0.1 0.2 0.5 0.0 0.6 -0.2 -0.6 -0.0 -0.7 -0.4
Number of treatments/medications taken 0.3 0.5 1.4 -1.2 -0.6 -0.8 0.9 -0.7 0.0 -0.2
Average weekly spirits intake 0.2 0.2 0.5 0.4 -0.3 -0.1 0.5 0.1 0.7 0.6
Sensitivity / hurt feelings 0.5 0.9 4.0 2.0 -0.6 -0.9 0.1 -0.9 0.5 -0.4
Frequency of depressed mood in last 2 weeks 2.1 2.9 7.5 0.1 -2.0 -2.7 0.0 -2.3 -0.3 -1.9
Hearing difficulty/problems: Yes 0.9 1.4 4.8 -0.3 1.7 0.5 2.2 0.3 -0.3 1.2
Relative age of first facial hair 0.1 0.3 0.6 -0.5 -0.4 0.4 -0.6 0.8 0.6 0.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.8 -0.4 -0.7 0.2 1.4 0.7 0.7 1.1
Ever used hormone-replacement therapy (HRT) 1.7 2.2 5.5 -0.3 -0.5 1.6 1.1 1.6 1.7 2.3
Ever had hysterectomy (womb removed) 1.3 1.5 3.9 -1.4 -2.0 -0.3 -1.0 1.6 -0.8 0.1
Systolic blood pressure, automated reading 0.8 2.4 5.4 -1.1 -2.3 -0.2 -2.3 2.0 -0.9 -0.4
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 3.2 -0.8 -1.0 -0.8 -1.8 0.4 -0.6 -0.8
Angina 3.9 5.1 13.7 -2.8 -3.7 -2.1 -2.3 0.9 -1.2 -1.4
Medication for hormone replacement therapy 0.6 0.6 1.9 -0.6 0.1 0.6 1.4 -0.1 1.1 0.9
Vitamin and mineral supplements 0.2 0.3 0.8 0.7 0.7 0.1 0.9 -0.4 0.3 0.5
Supplements: Zinc 1.7 1.9 4.7 -0.8 -0.2 1.8 0.3 2.2 0.9 1.9
Medication: Co-codamol 1.0 1.2 6.1 -2.5 -0.1 -0.1 1.3 -0.5 0.4 0.1
Medication: Metformin 1.0 1.3 2.8 1.4 0.6 -1.2 1.1 -1.7 -0.7 -1.1
Diabetes (father) 1.0 1.2 2.7 0.9 -0.1 -1.5 -1.0 -1.1 -0.8 -1.6
Diabetes (mother) 0.8 1.0 2.1 0.8 0.9 1.3 1.0 1.5 0.3 0.9
Severe depression (siblings) 0.1 0.1 0.4 0.1 -0.2 -0.6 -0.2 -0.4 0.3 -0.3
Pack years adult smoking proportion 1.5 2.2 5.4 -0.8 -2.1 -2.3 0.1 -0.2 -1.8 -1.3
Impedance of leg (right) 0.1 0.7 2.8 -1.7 -0.1 0.3 0.6 1.1 -0.5 0.5
Leg fat-free mass (left) 0.2 1.1 4.2 2.0 -0.1 -0.8 -0.5 -1.3 -0.1 -0.9
Trunk fat percentage 0.2 0.8 3.0 1.7 -0.0 -0.1 0.9 -0.9 0.8 0.3
Hand grip strength (right) 0.4 1.0 2.7 -0.2 -0.5 -0.8 -1.4 0.7 -1.6 -1.1
Townsend deprivation index at recruitment 0.6 0.8 3.5 -0.6 -1.9 -0.5 -0.7 0.4 0.8 0.3
Current tobacco smoking 1.2 2.0 4.1 0.7 -2.0 -1.9 -0.8 -1.4 -0.2 -1.7
Average weekly fortified wine intake 2.8 3.3 8.5 1.5 -2.1 -1.8 -2.9 -1.4 0.2 -1.6
Maternal smoking around birth 0.4 0.6 2.0 0.1 -0.7 0.7 -0.1 1.4 0.7 0.9
Fed-up feelings 1.0 1.8 4.1 1.3 -1.1 -1.9 -0.3 -2.0 -0.3 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.4 0.4 -1.6 -1.9 0.1 -1.0 0.3 -0.9
Relative age voice broke 1.0 1.5 4.4 -0.6 -0.5 0.8 1.3 1.1 1.4 2.1
Taking other prescription medications 0.7 1.1 3.6 -1.9 0.3 0.6 1.5 0.7 0.5 0.8
Age when periods started (menarche) 0.4 1.0 3.4 -0.8 1.0 1.8 -0.7 1.0 0.3 0.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 3.4 -0.2 -1.8 -0.7 -0.6 -0.1 0.6 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.9 -0.9 -0.2 0.2 0.7 0.3 0.6 0.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.8 -0.1 0.5 -0.1 0.5 0.4 -0.9 0.1
Qualifications: CSEs or equivalent 0.4 0.5 1.5 0.5 0.3 -0.9 1.2 -0.9 -0.0 -0.6
Serious illness, injury or assault to yourself 1.3 1.5 5.9 -1.6 0.4 -0.3 -0.0 1.3 -2.4 -0.5
High blood pressure 0.5 1.3 3.6 0.2 -1.9 -1.4 -1.4 -0.1 -0.5 -1.2
Hayfever, allergic rhinitis or eczema 1.2 2.6 9.6 -0.4 -1.2 -1.5 -1.4 0.7 -3.1 -1.5
Multivitamins +/- minerals 0.2 0.3 0.5 -0.3 -0.7 -0.3 -0.7 0.7 -0.7 -0.4
Stomach or abdominal pain in last month 1.8 2.3 5.7 -0.9 0.0 1.2 1.8 1.1 1.9 2.4
Supplements: Glucosamine 0.4 0.5 2.2 0.0 1.5 0.7 0.6 0.1 -0.6 -0.3
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 3.1 -0.7 -1.8 -1.3 -0.1 0.1 -0.2 -0.1
Medication: Atenolol 1.0 1.3 2.4 -0.6 -0.8 -1.2 -1.0 -0.9 -1.6 -1.4
Medication: Levothyroxine sodium 0.1 0.2 0.6 -0.5 0.2 0.1 0.8 -0.3 0.4 0.1
Sitting height 0.2 1.6 3.3 1.8 1.8 0.1 1.6 -1.6 0.1 0.0
Chronic bronchitis/emphysema (father) 0.8 0.9 1.6 -0.3 1.1 1.0 1.2 -0.4 1.3 0.8
High blood pressure (mother) 1.2 1.6 3.6 0.8 -0.4 -1.9 -0.5 -1.4 -1.5 -1.6
Body mass index (BMI) 0.2 0.9 3.4 1.9 -0.1 -0.2 0.6 -1.0 1.1 0.3
Impedance of leg (left) 0.1 0.6 2.2 -1.5 0.1 0.2 1.1 0.6 -0.4 0.5
Leg predicted mass (left) 0.2 1.1 4.2 2.0 -0.1 -0.8 -0.5 -1.3 -0.1 -0.9
Trunk fat mass 0.2 1.0 4.3 2.1 0.1 -0.3 0.9 -1.2 0.6 0.1
Waist circumference 0.1 0.3 1.0 1.0 -0.4 -0.5 0.7 -0.5 0.3 0.1
Number of incorrect matches in round 0.2 0.3 0.6 0.5 -0.6 -0.5 -0.6 -0.5 -0.1 -0.8
Past tobacco smoking 1.0 1.9 7.0 2.6 -0.1 -0.4 1.1 -1.5 1.5 0.6
Alcohol usually taken with meals 2.0 3.2 7.1 2.2 2.6 0.5 2.7 -1.1 0.3 1.4
Nervous feelings 0.6 1.1 2.4 1.6 -0.3 -1.2 1.0 -1.5 0.5 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.0 -0.1 -0.8 -0.8 1.4 -0.6 1.1 0.8
Hearing difficulty/problems with background noise 0.2 0.4 1.5 -0.8 0.2 -0.1 1.2 0.4 -0.1 0.5
Hair/balding pattern: Pattern 2 0.4 0.4 1.0 0.5 0.5 0.8 0.6 0.8 0.2 1.0
Had menopause 0.6 0.7 1.4 -0.9 -0.7 0.9 0.5 1.2 0.8 0.9
Had other major operations 0.6 0.8 3.2 -1.1 -1.8 -0.3 -0.6 0.6 -0.1 -0.1
Forced vital capacity (FVC) 0.2 0.7 3.3 0.5 -0.4 -0.4 -1.8 0.2 -0.8 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.7 -0.4 0.1 0.6 0.4 0.2 0.9 0.8
Ever unenthusiastic/disinterested for a whole week 2.6 3.2 14.6 1.2 0.0 0.6 1.4 -1.3 3.8 1.5
Qualifications: None of the above 0.8 1.7 4.8 -2.2 -0.3 1.4 0.4 1.4 1.3 1.2
Financial difficulties in last 2 years 5.3 7.1 14.1 -1.7 -3.6 -3.8 -2.4 -1.3 -2.0 -2.9
Mouth/teeth dental problems 1.6 2.4 8.2 2.9 -0.8 -1.5 -0.7 -2.0 0.1 -0.9
Heart attack 0.6 0.8 2.8 -1.2 -1.7 -0.6 -0.5 0.7 -0.3 -0.1
Allergy 1.5 3.4 6.1 0.4 2.5 2.1 2.1 -0.5 2.3 1.7
Pain all over the body in last month 3.3 3.6 5.6 -1.9 -2.2 -2.1 -1.8 -0.4 -1.8 -2.4
Diabetes (self-reported) 0.3 0.4 1.3 -0.3 -0.4 -1.1 0.8 -0.3 -0.6 -0.6
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 3.1 -1.2 -1.2 -0.8 -1.5 0.9 -1.8 -1.3
Medication: Ramipril 0.9 1.1 2.8 -1.0 -1.7 -1.3 -0.8 0.3 -0.9 -0.8
Medication: Simvastatin 0.2 0.2 0.6 -0.6 -0.5 -0.0 -0.7 0.0 0.6 0.1
Fluid intelligence score 0.6 1.2 1.9 1.0 -0.5 -1.3 -0.9 -1.3 -0.8 -1.4
Illnesses of siblings 2.0 2.7 6.2 -0.7 -1.2 -1.4 -2.5 -0.6 -2.0 -2.1
Neuroticism score 1.5 3.1 7.1 1.5 -2.4 -2.7 -1.2 -1.4 -0.3 -1.6
Weight 0.2 1.0 4.7 2.2 -0.1 -0.4 0.7 -1.1 0.7 0.2
Impedance of arm (right) 0.1 0.6 1.5 -0.8 -0.2 -0.4 -1.0 0.3 -1.2 -0.8
Arm fat percentage (right) 0.2 0.7 3.8 2.0 -0.2 -0.4 0.2 -0.9 0.4 -0.1
Trunk fat-free mass 0.1 0.7 3.4 1.8 0.6 -0.2 0.3 -0.9 0.0 -0.1
Hip circumference 0.4 1.6 5.9 2.4 0.2 -0.9 1.0 -1.7 0.2 -0.5
Time employed in main current job 1.2 1.4 3.9 2.0 1.9 0.6 0.8 -1.1 0.6 0.2
Alcohol intake versus 10 years previously 0.4 0.6 1.3 -0.7 -0.7 -0.7 0.5 -1.1 1.0 -0.5
Father’s age at death 1.0 1.4 3.8 -0.7 0.6 1.3 -1.9 1.4 -1.1 0.1
Worrier / anxious feelings 0.9 1.8 4.1 1.1 -0.8 -2.0 -0.4 -1.0 -1.6 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.4 6.2 0.4 -2.5 -1.7 -0.0 -0.1 0.5 -0.3
Falls in the last year 0.8 1.1 5.0 -0.5 -2.2 -1.2 -0.3 -0.8 0.8 0.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.5 0.2 0.1 -0.7 -0.1 -0.4 -0.7 -0.2
Number of live births 1.1 1.5 3.7 -1.2 0.6 1.0 1.1 0.1 1.9 1.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.9 0.9 -0.4 0.0 -1.0 0.2 0.2 0.2
Pulse rate 1.3 2.1 5.6 2.2 -0.0 -1.5 1.4 -2.4 0.6 -0.4
Happiness 0.9 1.1 4.1 -0.4 -1.3 -0.1 -2.0 1.0 -0.5 -0.7
Noisy workplace 0.9 1.2 3.0 -1.3 -1.0 0.2 -1.5 1.7 -0.3 -0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.6 0.7 0.1 0.2 -0.3 0.5 0.4 0.8
Serious illness, injury or assault of a close relative in last 2 years 2.8 3.2 6.6 -0.7 -2.3 -2.6 -1.0 -0.3 -2.3 -1.9
Mouth/teeth dental problems: Dentures 2.2 3.6 6.0 -0.7 2.0 2.5 2.4 0.9 1.9 2.2
Asthma 2.4 4.8 10.2 -3.2 -3.0 -2.0 -2.3 1.1 -1.5 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.8 1.2 -0.1 -0.1 1.3 -1.3 1.3 0.7
Medication: Cholesterol lowering 0.3 0.4 1.8 0.8 -0.2 0.3 -0.1 -0.4 1.3 0.5
Depression (self-reported) 0.8 1.0 3.6 0.5 0.6 0.7 1.2 -0.6 1.9 0.6
Medication: Lansoprazole 2.8 3.2 6.6 -1.3 1.1 1.8 2.6 2.4 -0.1 1.9
Prospective memory result 0.3 0.4 1.0 -0.7 0.0 0.7 0.2 1.0 0.5 0.8
Lung cancer (father) 0.8 0.9 2.4 -1.5 0.3 0.9 0.2 1.5 -0.3 0.9
Illnesses of mother 0.7 0.8 1.8 -0.6 -0.9 1.0 -0.8 0.8 1.4 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.7 0.9 -0.8 -0.7 -1.7 0.2 -1.0 -0.6
Pulse wave Arterial Stiffness index 0.7 0.8 2.6 0.1 -1.6 -0.2 0.4 0.2 1.6 0.7
Impedance of arm (left) 0.1 0.3 1.0 -0.9 -0.1 -0.1 -0.1 0.7 -1.0 -0.3
Arm fat mass (right) 0.2 0.8 4.5 2.1 -0.0 -0.3 0.6 -0.9 0.3 -0.0
Trunk predicted mass 0.1 0.7 3.4 1.8 0.6 -0.3 0.3 -0.9 -0.1 -0.2
Standing height 0.0 0.3 1.3 1.1 0.6 0.1 0.6 -0.2 -0.5 0.0
Length of working week for main job 0.8 0.8 2.5 -1.6 -0.4 1.1 -0.6 1.0 0.6 0.6
Exposure to tobacco smoke at home 0.7 0.8 2.1 0.3 0.2 -1.0 0.7 -1.4 -0.9 -1.1
Breastfed as a baby 0.5 0.6 1.3 1.1 -1.1 0.0 -1.1 0.6 0.2 0.0
Tense / ‘highly strung’ 1.2 1.9 4.0 -0.0 -2.0 -2.0 -1.2 -0.7 -1.0 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 4.2 -1.2 -2.0 -1.1 -0.2 -0.4 1.6 -0.3
Hair/balding pattern: Pattern 4 0.2 0.5 1.4 -1.2 1.1 0.2 0.7 -0.6 -0.1 -0.3
Birth weight of first child 0.4 0.8 2.8 -0.5 0.4 -0.3 -1.7 -1.1 -0.2 -1.1
Peak expiratory flow (PEF) 0.2 0.5 1.4 0.6 -0.4 0.5 0.3 0.4 1.2 1.1
Pulse wave reflection index 0.6 0.7 1.7 -0.9 -0.7 0.6 -0.3 1.3 0.7 0.8
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.7 0.8 -1.3 -1.6 0.1 -1.4 0.4 -0.5
Loud music exposure frequency 1.5 1.7 3.2 0.8 -0.9 -1.7 -0.8 -1.6 -0.8 -1.8
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 4.1 1.2 -1.2 -1.9 -2.0 -1.0 -1.6 -1.8
Mouth/teeth dental problems: Bleeding gums 0.9 1.2 3.0 -1.7 -0.8 -0.4 -1.3 0.9 -1.2 -0.8
Blood clot in the leg (DVT) 5.2 6.8 25.2 5.0 -1.6 -1.1 -0.7 -2.8 3.2 -0.4
Medication: Paracetamol 0.9 1.5 4.9 0.8 -1.0 -1.7 0.4 -2.2 0.6 -0.8
Headache pain in last month 0.3 0.5 1.3 0.2 0.6 0.6 1.1 0.3 0.2 1.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 2.0 -1.1 0.4 0.1 -0.2 0.8 -1.4 -0.3
Glaucoma (self-reported) 0.7 0.9 1.5 -0.2 -1.1 -1.1 -1.0 -0.2 -1.0 -1.2
Gout (self-reported) 2.1 2.9 4.9 1.6 1.9 0.9 2.2 -1.8 2.2 0.9
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.6 -0.6 0.6 0.2 1.2 -0.5 0.8 0.4
Medication: Amlodipine 0.9 1.2 2.7 -1.6 -0.8 0.8 0.2 1.2 1.4 1.2
Medication: Ventolin 100micrograms inhaler 1.1 1.4 6.0 -2.5 -1.3 -0.4 0.0 1.2 0.1 0.1
Birth weight 0.8 1.6 3.5 -1.6 0.7 1.0 0.9 1.9 -1.7 0.6
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.8 -0.1 0.9 0.3 0.5 0.1 0.1 0.9
High blood pressure (siblings) 2.1 3.0 6.0 0.1 0.4 1.9 1.7 1.8 2.2 2.5
Forced vital capacity (FVC), Best measure 0.3 1.0 2.9 0.6 -0.2 -0.6 -1.7 0.4 -1.6 -0.8
Body fat percentage 0.2 0.8 3.1 1.8 -0.4 -0.5 0.9 -1.0 0.6 0.2
Leg fat percentage (right) 0.2 0.7 1.8 1.3 -0.4 -0.3 1.2 -0.6 0.7 0.6
Arm fat-free mass (right) 0.1 0.6 2.3 1.5 -0.5 -0.6 0.3 -0.9 0.4 -0.1
Exposure to tobacco smoke outside home 1.1 1.5 4.0 -2.0 -0.5 0.5 1.0 1.9 0.2 1.1
Comparative body size at age 10 0.4 1.0 3.1 1.8 0.1 0.2 -0.3 -0.9 1.8 -0.0
Number of full brothers 0.8 1.0 2.0 0.8 0.8 0.6 1.3 -0.2 1.2 1.4
Worry too long after embarrassment 0.9 1.5 2.7 1.6 -1.2 -1.6 -1.3 -0.7 -0.5 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.5 -0.5 -1.2 -1.2 0.7 -1.1 1.1 -0.3
Wheeze or whistling in the chest in last year 0.3 0.6 1.3 -1.0 -1.1 -0.8 0.9 0.2 -0.4 -0.0
Number of children fathered 0.7 0.8 1.4 0.9 1.2 0.7 0.8 0.8 0.1 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.6 0.5 -0.2 -0.1 -0.5 0.2 -0.8 0.0
Age at first live birth 0.4 0.6 3.2 0.1 1.8 0.9 0.2 -0.0 -0.6 0.2
Pulse wave peak to peak time 0.9 1.0 3.5 -0.1 1.5 0.2 -0.6 0.0 -1.9 -0.9
Health satisfaction 0.3 0.4 1.8 -0.1 -1.4 -0.4 -0.3 0.3 0.5 -0.1
Shortness of breath walking on level ground 0.9 1.0 4.8 0.1 -2.2 -1.2 -0.6 0.2 0.7 -0.2
Qualifications: College or University degree 0.2 0.7 2.2 1.5 1.3 0.2 -0.3 -0.5 -0.6 0.2
Eye problems/disorders: None of the above 0.1 0.2 0.5 0.2 0.2 0.5 0.5 0.2 0.1 0.7
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.0 -1.0 -1.7 -1.5 -0.2 -0.4 -0.4 -0.9
Emphysema/chronic bronchitis 0.8 0.9 2.4 -1.6 -0.9 -0.3 1.0 0.7 0.5 0.9
Medication for pain relief, constipation, heartburn 0.7 1.2 3.1 -0.7 1.7 0.8 -0.5 1.0 -1.8 -0.4
Neck or shoulder pain in last month 0.7 1.0 2.2 0.6 -1.5 -1.4 -0.6 -1.0 1.0 -0.1
Medication: Blood pressure 0.3 0.6 1.8 0.5 -1.4 -0.9 -1.1 -0.2 0.2 -0.4
Angina (self-reported) 3.5 4.6 11.6 -3.0 -3.4 -1.9 -2.0 1.0 -1.3 -1.2
Migraine (self-reported) 1.2 1.4 4.9 0.9 -1.5 -0.8 -2.2 -0.2 -0.6 -1.0
Medication: Ibuprofen 0.7 0.9 3.3 0.9 -0.4 -1.1 0.6 -1.8 0.4 -0.4
Medication: Allopurinol 0.6 0.8 2.3 0.6 1.2 0.4 1.5 -1.1 0.7 0.1
Medication: Omeprazole 0.4 0.5 0.9 0.8 -0.3 -0.5 0.8 -0.8 1.0 0.4
Medication: Seretide 50 evohaler 0.7 0.8 1.9 -1.2 -1.1 0.4 -0.8 1.4 0.3 0.4
Mean time to correctly identify matches 1.0 2.0 4.7 -1.5 1.2 2.0 -0.4 2.2 -0.5 1.1
Heart disease (mother) 0.7 0.8 2.3 -0.7 -1.2 -1.5 -0.1 -0.6 -0.7 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.5 4.2 -1.4 -2.0 -1.3 -1.9 0.6 -2.0 -1.4
Whole body fat mass 0.3 1.1 4.6 2.1 -0.1 -0.4 0.9 -1.2 0.8 0.1
Leg fat mass (right) 0.2 0.9 3.4 1.8 -0.1 -0.3 1.1 -0.9 0.6 0.3
Arm predicted mass (right) 0.2 0.9 4.0 2.0 -0.4 -0.6 0.3 -1.1 0.4 -0.2
Pulse rate, automated reading 0.7 2.3 7.7 1.6 0.1 -1.8 1.3 -2.8 0.3 -1.0
Alcohol intake frequency. 0.4 0.8 2.9 0.1 -1.7 -1.0 -0.5 -0.4 1.2 -0.4
Comparative height size at age 10 0.2 1.4 2.8 1.7 -0.9 -1.3 -0.6 -0.2 -1.7 -1.0
Number of full sisters 0.6 0.8 2.2 -0.7 -0.9 -1.5 0.4 -0.9 -0.5 -0.9
Suffer from ‘nerves’ 0.9 1.4 4.4 2.1 -1.3 -0.8 0.7 -0.5 1.5 0.8
Overall health rating 1.0 2.2 6.7 -0.3 -2.4 -2.6 -0.0 -1.4 -0.4 -1.1
Chest pain or discomfort 0.9 1.4 4.9 -1.2 -2.2 -1.2 -0.8 -0.1 -0.4 -0.9
Had major operations 0.9 1.1 2.5 -1.6 0.3 0.8 1.2 0.2 1.3 1.1
Age at last live birth 0.2 0.3 1.4 -0.1 1.2 0.6 -0.2 -0.3 -0.3 0.1
Family relationship satisfaction 1.4 1.8 6.1 -1.2 -2.5 -0.7 -1.5 1.4 -0.5 -0.3
Leg pain on walking 4.1 5.1 13.0 0.3 -2.7 -3.6 -1.3 -2.4 -0.9 -2.6
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.2 0.3 -0.2 0.3 0.5 1.1 -0.5 0.5
Commuting to job workplace: Car/motor vehicle 0.2 0.3 1.0 1.0 0.3 -0.4 -0.7 -0.1 -0.3 0.0
Illness, injury, bereavement, stress in last 2 years 1.7 2.1 7.3 1.3 1.1 1.5 0.3 -0.4 2.7 1.4
Medication: Aspirin 2.4 3.2 12.2 0.4 -3.5 -2.1 -1.9 -0.2 -0.3 -1.4
Supplements: Vitamin C 0.6 0.7 2.3 -0.8 -0.7 -0.3 -1.5 0.1 -0.7 -0.9
Knee pain experienced in last month 0.7 1.2 3.8 1.1 0.5 -0.4 1.0 -1.9 1.3 0.1
Hypertension (Self-reported) 0.5 1.5 4.3 0.2 -2.1 -1.6 -1.4 -0.2 -0.5 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.4 0.6 0.9 0.7 1.6 -0.6 1.4 0.9
Illnesses of father: Heart disease 0.3 0.5 2.3 -1.5 -0.5 -0.2 -0.5 0.7 -0.1 -0.2
Illnesses of siblings: Diabetes 1.2 1.5 4.4 0.9 1.8 1.1 2.1 0.2 0.1 0.8
Smoking status: Previous 1.1 1.6 5.2 -2.3 0.9 1.0 -0.7 1.7 -0.9 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.1 -1.4 0.0 -0.4 -0.4 0.8 -1.8 -0.7
Whole body fat-free mass 0.1 0.8 4.1 2.0 0.2 -0.5 -0.1 -1.1 -0.1 -0.5
Leg fat-free mass (right) 0.2 1.2 4.2 2.1 0.2 -0.8 -0.2 -1.5 -0.2 -0.9
Arm fat percentage (left) 0.2 0.7 3.5 1.9 -0.3 -0.4 0.6 -0.8 0.4 0.1
Average weekly red wine intake 1.4 2.1 9.7 3.1 1.0 -0.8 -0.6 -1.6 -0.2 -0.6
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.8 0.3 1.7 0.7 1.2 -0.2 -0.3 0.5
Mood swings 0.6 1.1 3.1 0.6 -0.6 -1.3 -0.7 -1.8 0.4 -1.2
Loneliness, isolation 0.6 0.8 1.7 -0.1 -1.1 -1.1 -0.6 -1.3 0.3 -0.9
Long-standing illness, disability or infirmity 1.3 1.9 6.9 -2.6 -1.5 -1.3 1.2 0.5 -0.9 0.1
Ever had bowel cancer screening 1.8 2.1 4.0 -2.0 1.4 1.7 1.4 1.4 0.2 1.4
Diabetes diagnosed by doctor 0.3 0.5 1.1 -0.8 -0.3 -1.1 1.0 -0.1 -0.8 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 2.3 -1.5 -1.2 -0.2 -1.0 1.1 -1.0 -0.5
Friendships satisfaction 1.7 2.1 4.7 -0.9 -2.2 -1.7 -1.6 0.2 -1.5 -1.4
Qualifications: nursing, teaching 0.4 0.7 1.2 1.0 0.2 -1.1 -0.8 -0.7 -1.1 -0.6
Commuting to job workplace: Walk 0.1 0.1 0.5 -0.7 -0.0 0.1 0.2 -0.4 0.3 -0.3
Eye problems/disorders: Cataract 0.1 0.1 0.3 -0.5 -0.3 -0.1 -0.3 0.0 0.4 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.2 -1.7 -0.7 -0.1 -0.7 1.8 -1.4 -0.1
Medication for cholesterol 0.4 0.5 2.1 1.4 1.0 0.5 -0.6 0.1 -0.2 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.8 5.0 -0.3 1.7 2.2 0.7 1.7 0.4 1.2
Back pain experienced in last month 0.4 0.6 1.5 -0.8 -0.8 -0.4 1.2 0.6 0.6 0.5
Mineral and other dietary supplements 1.1 1.4 3.5 0.3 -1.6 -1.9 -0.9 -1.4 0.4 -1.0
Breast cancer (self-reported) 2.8 3.4 5.9 1.6 -1.8 -2.4 -1.5 -1.5 -1.2 -2.4
Asthma (self-reported) 2.4 4.7 8.8 -2.9 -3.0 -2.0 -2.4 1.0 -1.6 -1.6
Osteoporosis (self-reported) 1.3 1.6 7.2 -2.7 0.0 0.8 1.1 0.8 0.5 1.0
Osteoarthritis (self-reported) 0.7 0.9 3.2 -1.8 -1.3 -0.4 0.3 -0.2 1.1 -0.1
Medication: Aspirin 2.2 2.9 11.2 -0.4 -3.3 -1.7 -1.8 0.6 -0.8 -1.3
Medication: Gliclazide 0.4 0.4 0.9 -0.8 -0.8 -0.6 -0.4 0.1 -0.6 -1.0
Illnesses of father: None of the above (group 1) 1.6 1.9 3.7 -0.3 0.4 1.8 1.4 1.9 0.9 1.9
Smoking status: Current 1.5 2.4 4.9 0.6 -2.2 -2.2 -0.9 -1.7 -0.3 -1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.1 0.9 -0.7 0.4 -0.8 -0.0 1.4 0.7
Whole body water mass 0.2 0.9 3.8 2.0 0.1 -0.7 -0.1 -1.3 -0.0 -0.6
Leg predicted mass (right) 0.2 1.2 4.3 2.1 0.1 -0.9 -0.3 -1.5 -0.2 -1.0
Arm fat mass (left) 0.2 0.9 4.6 2.1 0.1 -0.2 0.8 -0.9 0.6 0.2
Number of self-reported non-cancer illnesses 3.0 5.2 16.2 -3.0 -4.0 -1.9 -2.0 1.3 -0.6 -1.3
Average weekly champagne plus white wine intake 0.6 0.8 2.9 -0.7 0.3 0.8 -0.4 1.7 -0.3 1.1
Miserableness 0.8 1.3 2.2 0.9 -0.9 -1.5 -1.2 -1.3 -0.5 -1.4
Guilty feelings 0.7 1.0 4.6 0.2 -2.1 -1.3 -0.5 0.3 0.3 -0.2
Wears glasses or contact lenses 0.7 0.8 1.4 1.2 0.9 0.2 1.1 -1.1 0.9 0.4
Ever taken oral contraceptive pill 0.8 0.9 1.8 0.6 1.4 -0.3 0.3 -0.9 -1.2 -1.3
Hearing aid user 0.4 0.5 2.5 -0.1 -1.6 -0.7 0.1 0.7 -0.2 0.1
Mother’s age at death 1.5 1.8 4.4 2.1 2.1 1.4 1.3 -0.1 -0.2 0.7
Financial situation satisfaction 1.2 1.5 3.2 -1.0 -1.1 -1.3 -1.0 -0.0 -1.8 -1.7
Tinnitus: Yes, now most or all of the time 3.1 3.6 7.0 -1.6 -1.6 -1.3 -2.6 0.6 -2.5 -2.1
Commuting to job workplace: Public transport 0.3 0.4 1.3 1.1 -0.9 -0.2 -0.1 -0.4 0.4 -0.1
Eye problems/disorders: Glaucoma 0.6 0.7 1.6 0.1 -0.4 -1.1 -0.6 -1.0 -0.5 -1.3
Medication: Blood pressure 1.1 2.0 3.8 -0.4 -1.9 -1.9 -0.9 -0.1 -1.7 -1.7
Pain type(s) experienced in last month: Hip pain 0.9 1.1 3.2 -1.1 -0.5 0.7 0.8 1.8 0.4 1.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 2.0 0.3 0.6 0.2 -0.2 0.4 -1.4 -0.4
High cholesterol (Self-reported) 0.4 0.6 1.9 -0.8 -0.6 0.5 0.2 1.4 0.4 1.1
Medication: Bendroflumethiazide 1.4 2.1 3.4 1.7 -0.5 -1.3 -1.7 -1.2 -1.3 -1.8
Medication: Paracetamol 1.3 2.0 5.7 0.7 -1.1 -2.1 0.3 -2.4 -0.2 -1.2
Medication: Lisinopril 0.6 0.8 2.1 -0.3 -1.4 -0.4 -1.4 -0.2 0.5 -0.8
Medication: Atorvastatin 1.9 2.3 5.2 -1.0 -0.5 0.8 2.3 2.3 0.0 2.0
Illnesses of father: High blood pressure 3.6 4.5 8.1 1.0 -2.5 -2.9 -2.2 -2.3 -0.7 -2.3
Alcohol drinker status: Never 1.1 1.3 2.5 0.7 -1.3 -1.6 -1.4 -0.8 -0.7 -1.2
Ever smoked 0.4 0.8 2.2 -1.5 0.6 0.1 -0.2 0.3 -1.4 -0.8
Basal metabolic rate 0.1 0.8 3.9 2.0 0.2 -0.5 0.1 -1.1 0.1 -0.4
Leg fat percentage (left) 0.3 0.9 2.2 1.5 -0.3 -0.3 1.5 -0.9 0.9 0.7
Arm fat-free mass (left) 0.1 0.6 2.6 1.6 -0.2 -0.6 -0.0 -1.1 0.2 -0.4
Number of operations (self-reported) 1.8 2.7 8.8 -3.0 -1.8 0.8 -0.2 2.0 0.9 1.1
Average weekly beer plus cider intake 0.6 0.9 3.9 -2.0 -1.1 0.3 -0.4 0.9 -0.0 -0.3
Irritability 1.5 2.5 4.0 2.0 -1.7 -1.9 -1.5 -1.7 0.2 -1.3
Risk taking 1.0 1.5 5.6 -0.0 -0.4 1.1 0.4 0.4 2.4 1.8
Ever had prostate specific antigen (PSA) test 1.5 1.7 3.4 -0.3 -1.4 -1.9 -1.1 -1.0 -1.4 -1.5
Fractured/broken bones in last 5 years 0.1 0.2 0.5 -0.3 -0.2 -0.4 -0.3 0.2 -0.7 -0.5
Age started oral contraceptive pill 0.2 0.2 0.4 -0.5 0.3 0.6 -0.1 0.6 -0.2 0.4
Diastolic blood pressure, automated reading 0.4 1.3 4.5 0.7 2.1 1.0 1.0 -1.0 0.6 0.7
Ever depressed for a whole week 1.4 1.7 9.4 -0.3 0.3 0.9 0.4 -0.8 3.1 0.9
Unable to work because of sickness or disability 1.7 2.2 5.6 0.1 -1.7 -2.4 -0.1 -2.2 -0.2 -1.4
Commuting to job workplace: Cycle 0.6 0.7 1.8 1.4 -0.8 -0.7 -1.1 -0.4 -0.6 -0.6
Myopia 1.0 1.5 3.0 1.2 0.6 -0.7 -1.5 -0.6 -1.6 -1.7
Vascular/heart problems diagnosed by doctor 0.6 1.6 5.8 0.5 2.4 1.4 1.1 -0.5 0.7 1.0
Cholesterol lowering medication 0.9 1.4 2.7 -1.4 -0.7 0.8 0.7 1.6 0.9 1.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.0 0.8 -0.6 -1.0 0.3 -0.8 0.1 -0.4
Pain experienced in last month 0.5 0.8 2.0 0.7 0.1 -0.4 -1.1 -0.4 -1.4 -1.1
Supplements: Calcium 1.4 1.5 4.0 -2.0 -0.2 1.0 0.1 2.0 -1.1 0.6
Basal cell carcinoma (self-reported) 1.0 1.1 1.8 1.1 0.5 -1.1 0.9 -1.3 -1.2 -1.1
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.2 -1.2 -1.8 -0.6 -0.6 0.8 -0.4 -0.1
Deep venous thrombosis (DVT) (self-reported) 6.0 7.7 29.0 5.4 -1.6 -1.2 -0.8 -3.0 3.3 -0.4
Heart disease (siblings) 1.0 1.2 4.4 -0.2 -0.2 0.7 1.1 -0.1 2.1 1.4
Alcohol drinker status: Previous 1.3 1.4 6.1 -0.8 -2.5 -1.1 -0.8 0.2 1.2 -0.0
Pack years of smoking 0.7 1.0 2.6 -0.5 -1.3 -1.6 0.5 -0.2 -1.1 -0.8
Impedance of whole body 0.1 0.5 2.0 -1.4 -0.2 0.0 0.4 0.8 -0.7 0.1
Leg fat mass (left) 0.3 1.2 4.5 2.1 -0.0 -0.3 1.3 -1.1 0.7 0.4
Arm predicted mass (left) 0.2 0.8 3.5 1.9 -0.1 -0.6 0.4 -1.2 0.4 -0.3