Hub : Genes

BMP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hippocampus 0.394 0.115 0.0011 0.005 NA 0.043 NA 0.008 0.25 NA 0.036 NA 0.2
2 GTEx Ovary 0.488 0.121 0.0061 -0.010 NA 0.049 NA 0.021 0.68 NA 0.024 NA 0.1

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.2 0.2 -0.5 -0.4
Bipolar Disorder or Schizophrenia 0.0 0.1 0.1 -0.3 -0.3
Depressed Affect (Nagel 2018) 0.4 0.9 1.7 -1.3 0.2
Depression (Nagel 2018) 2.5 3.8 5.0 1.6 -2.2
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.5 -0.2 0.7
Neuroticism (Nagel 2018) 1.1 2.6 4.7 -2.2 -0.7
Schizophrenia (2018) 0.0 0.1 0.1 0.1 0.4
Schizophrenia vs Biploar Disorder 0.0 0.1 0.1 0.3 0.1
Worry (Nagel 2018) 0.8 1.7 2.8 -0.7 -1.7
Alzheimer’s Disease (in mother) 1.3 1.5 2.9 -0.3 -1.7
Alzheimer’s Disease (in father) 0.4 0.4 0.6 0.5 0.8
Alzheimer’s Disease (including proxy) 0.2 0.3 0.6 0.1 -0.7
Crohns Disease (2017) 0.1 0.1 0.2 -0.4 -0.3
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 0.2 -0.1
Ulcerative Colitis (UC) 0.6 1.1 2.1 1.5 0.3
Major Depression (MDD) 0.4 0.5 1.0 -1.0 -0.0
Reaction Time 0.4 0.8 1.1 1.0 -0.7
Verbal and Numeric Reasoning (VNR) 0.6 1.4 2.0 -1.4 0.9
Breast Cancer 0.4 1.0 1.6 -1.3 -0.6
Ovarian Cancer 0.3 0.3 0.6 -0.8 0.3
Prostate Cancer 0.3 0.4 0.9 -0.9 0.0
Age at First Birth 0.1 0.1 0.1 -0.1 0.4
Bipolar Disorder (2011) 0.1 0.1 0.3 -0.5 -0.0
Body Mass Index (BMI) (2010) 0.6 0.9 1.5 -1.2 0.5
Coronary Artery Disease (CAD) 0.4 0.5 0.9 -0.1 1.0
Crohns Disease (2012) 0.5 0.8 1.6 0.1 -1.3
Mean Putamen Volume 0.6 0.7 1.4 0.2 -1.2
Fasting Glucose 0.2 0.2 0.3 0.3 0.6
HbA1C 0.3 0.3 0.6 0.2 0.8
HDL Cholesterol 0.0 0.1 0.1 -0.3 0.3
LDL Cholesterol 0.3 0.5 0.8 0.9 0.5
Lupus 0.8 1.2 1.5 1.0 1.2
Neuroticism (2016) 3.7 5.3 5.8 -2.2 -2.4
Primary Biliary Cirrhosis 0.1 0.2 0.3 -0.0 0.6
Rheumatoid Arthritis 0.5 0.7 1.3 0.4 -1.1
Schizophrenia (2014) 0.1 0.1 0.1 -0.3 0.3
Triglycerides 0.1 0.2 0.4 0.7 -0.1
Type 2 Diabetes (T2D) (2012) 1.5 1.7 2.8 1.7 -0.8
Ulcerative Colitis 1.0 1.5 2.3 0.9 -1.5
Blood Eosinophil Count 0.7 5.1 8.1 2.9 1.5
Blood Platelet Count 0.2 2.2 4.2 2.0 0.5
Blood Red Count 0.1 1.4 2.9 -0.1 1.7
Blood White Count 0.0 0.0 0.0 0.1 -0.1
Heel T-Score 2.7 21.3 30.2 -5.5 -3.5
BMI 1.8 10.3 19.1 -4.4 1.2
Height 6.5 125.2 163.8 12.8 -9.3
Waist Hip Ratio (WHR) 3.8 16.9 18.8 3.9 -4.3
Systolic Blood Pressure 1.2 5.8 6.4 -2.3 2.5
Smoking Status 0.1 0.1 0.2 0.3 -0.4
Allergy or Eczema 0.4 1.0 1.4 -1.2 0.8
Cardiovascular Disease 0.1 0.3 0.5 -0.7 0.5
Hypothyroidism (self reported) 1.9 4.4 6.9 2.6 1.4
Respiratory disease 0.4 0.9 1.4 -1.2 0.6
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.0 -0.3 -1.0
Lung FEV1/FVC ratio 1.2 6.3 11.5 3.4 -1.1
Lung FVC 2.0 10.2 12.8 -2.8 3.6
Neuroticism 1.1 2.8 3.0 -1.7 -1.6
Chronotype (morning person) 1.9 4.3 5.9 -1.6 -2.4
Hair Pigment 0.0 0.5 0.7 -0.6 -0.8
Tanning 0.0 0.3 0.6 -0.7 -0.1
Hand grip strength (left) 0.2 0.6 1.0 0.5 1.0
Number of treatments/medications taken 0.0 0.0 0.0 -0.0 -0.2
Average weekly spirits intake 0.2 0.2 0.3 -0.6 -0.4
Sensitivity / hurt feelings 0.1 0.2 0.5 -0.7 0.1
Frequency of depressed mood in last 2 weeks 1.5 2.1 2.3 1.3 -1.5
Hearing difficulty/problems: Yes 0.1 0.2 0.2 -0.5 -0.3
Relative age of first facial hair 0.3 0.7 1.0 1.0 0.6
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 1.9 1.4 -0.8
Ever used hormone-replacement therapy (HRT) 1.5 2.0 3.5 -0.7 -1.9
Ever had hysterectomy (womb removed) 0.9 1.0 1.6 -1.3 -0.7
Systolic blood pressure, automated reading 1.3 3.7 7.5 -2.7 0.2
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.3 -0.4 -1.5
Angina 0.2 0.3 0.3 0.6 -0.4
Medication for hormone replacement therapy 1.2 1.4 2.0 1.4 -0.9
Vitamin and mineral supplements 0.3 0.4 0.7 -0.4 -0.8
Supplements: Zinc 0.5 0.5 0.8 0.5 0.9
Medication: Co-codamol 0.1 0.1 0.1 -0.1 -0.4
Medication: Metformin 0.5 0.7 1.2 -0.5 -1.1
Diabetes (father) 1.2 1.5 3.0 -0.2 -1.7
Diabetes (mother) 0.4 0.5 1.0 -1.0 -0.1
Severe depression (siblings) 1.2 1.3 2.6 -1.6 0.3
Pack years adult smoking proportion 0.4 0.6 1.2 0.0 1.1
Impedance of leg (right) 2.1 10.2 12.9 2.8 -3.6
Leg fat-free mass (left) 0.3 1.7 2.4 1.5 -1.0
Trunk fat percentage 0.1 0.4 0.8 -0.9 -0.1
Hand grip strength (right) 0.3 0.9 1.2 -0.7 1.1
Townsend deprivation index at recruitment 0.5 0.8 1.4 1.2 -0.2
Current tobacco smoking 0.7 1.2 1.2 1.1 -1.1
Average weekly fortified wine intake 0.5 0.6 1.2 -1.1 -0.3
Maternal smoking around birth 1.8 2.5 4.7 0.6 2.2
Fed-up feelings 0.6 1.1 2.2 -1.5 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.9 3.9 5.7 2.4 -1.4
Relative age voice broke 0.3 0.4 0.8 0.9 -0.1
Taking other prescription medications 0.9 1.3 2.6 1.6 0.1
Age when periods started (menarche) 0.5 1.3 2.5 0.3 1.6
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 0.8 -0.9 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 2.7 6.1 8.1 -2.0 -2.8
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 2.0 1.4 -1.2
Qualifications: CSEs or equivalent 0.4 0.6 0.7 0.8 0.7
Serious illness, injury or assault to yourself 1.8 2.2 4.2 2.1 0.4
High blood pressure 0.1 0.3 0.4 -0.5 0.6
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.0 -0.9 1.0
Multivitamins +/- minerals 0.5 0.7 1.3 1.1 -0.3
Stomach or abdominal pain in last month 0.3 0.3 0.7 0.8 -0.0
Supplements: Glucosamine 1.7 2.2 2.3 1.4 1.5
Diverticular disease/diverticulitis (self-reported) 2.0 2.4 2.4 -1.5 -1.6
Medication: Atenolol 0.1 0.1 0.3 -0.0 -0.5
Medication: Levothyroxine sodium 0.7 1.2 1.5 1.2 1.0
Sitting height 3.3 23.4 41.6 6.5 -2.3
Chronic bronchitis/emphysema (father) 1.8 2.1 3.5 -1.9 0.8
High blood pressure (mother) 0.1 0.2 0.4 0.2 0.6
Body mass index (BMI) 1.4 6.1 10.5 -3.2 1.3
Impedance of leg (left) 2.2 10.7 11.2 3.3 -3.2
Leg predicted mass (left) 0.3 1.7 2.3 1.5 -1.0
Trunk fat mass 0.1 0.4 0.8 -0.0 -0.9
Waist circumference 0.1 0.3 0.5 -0.3 -0.7
Number of incorrect matches in round 2.5 4.1 6.9 -2.6 -1.2
Past tobacco smoking 0.2 0.3 0.5 0.7 0.4
Alcohol usually taken with meals 0.2 0.3 0.5 0.2 0.7
Nervous feelings 0.2 0.4 0.7 0.0 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.1 1.5 0.2
Hearing difficulty/problems with background noise 0.7 1.1 2.1 -1.5 0.1
Hair/balding pattern: Pattern 2 1.1 1.4 2.8 1.7 -0.2
Had menopause 2.0 2.5 4.2 -2.1 -0.9
Had other major operations 1.0 1.2 2.0 0.6 1.4
Forced vital capacity (FVC) 1.1 4.1 8.0 2.8 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 2.6 6.0 8.0 -2.8 -2.0
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 0.3 -0.3 -0.5
Qualifications: None of the above 0.1 0.1 0.3 0.5 0.1
Financial difficulties in last 2 years 2.1 2.8 5.5 -0.0 2.4
Mouth/teeth dental problems 1.1 1.6 3.1 0.4 1.8
Heart attack 0.2 0.3 0.5 0.2 -0.7
Allergy 0.8 1.8 2.7 0.9 -1.7
Pain all over the body in last month 0.4 0.4 0.8 0.9 -0.3
Diabetes (self-reported) 0.7 1.0 1.3 -0.9 -1.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.4 -0.3 0.6
Medication: Ramipril 0.7 0.8 1.7 1.3 -0.1
Medication: Simvastatin 0.3 0.4 0.7 0.8 0.4
Fluid intelligence score 1.8 3.8 4.2 -1.8 2.1
Illnesses of siblings 0.1 0.1 0.1 -0.3 -0.2
Neuroticism score 0.7 1.4 2.2 -1.5 -0.9
Weight 0.3 1.6 2.0 1.1 -1.4
Impedance of arm (right) 0.6 2.9 5.5 2.3 0.6
Arm fat percentage (right) 1.7 6.5 8.7 -3.0 2.1
Trunk fat-free mass 1.7 9.5 11.8 2.7 -3.4
Hip circumference 0.1 0.4 0.5 -0.6 0.7
Time employed in main current job 2.7 3.1 6.1 -2.5 -0.4
Alcohol intake versus 10 years previously 0.6 1.0 1.1 0.9 -1.0
Father’s age at death 0.4 0.5 0.6 -0.6 0.8
Worrier / anxious feelings 0.6 1.2 1.9 -0.6 -1.4
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 5.6 2.4 -0.8
Falls in the last year 0.0 0.1 0.1 0.3 -0.2
Hair/balding pattern: Pattern 3 3.6 5.4 10.8 -3.3 -0.0
Number of live births 0.4 0.5 0.9 -0.4 1.0
Forced expiratory volume in 1-second (FEV1) 1.8 5.9 11.8 3.4 0.0
Pulse rate 0.2 0.4 0.8 0.1 0.9
Happiness 0.2 0.3 0.5 -0.7 0.2
Noisy workplace 2.0 2.4 3.7 1.9 -1.1
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.2 0.1 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.4 1.2 -0.4
Mouth/teeth dental problems: Dentures 0.3 0.5 1.0 -0.1 -1.0
Asthma 0.9 1.9 2.4 -1.6 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.1 -0.0 0.4
Medication: Cholesterol lowering 0.7 1.1 2.1 -0.4 -1.4
Depression (self-reported) 0.7 0.9 1.3 1.1 -0.7
Medication: Lansoprazole 0.4 0.5 1.0 -0.1 -1.0
Prospective memory result 2.3 2.8 4.8 -0.9 -2.2
Lung cancer (father) 1.0 1.1 2.0 -1.4 -0.5
Illnesses of mother 0.6 0.7 1.2 1.1 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.1 8.2 2.9 -0.1
Pulse wave Arterial Stiffness index 1.4 1.6 2.7 0.7 -1.6
Impedance of arm (left) 0.5 2.4 4.7 2.2 0.2
Arm fat mass (right) 0.4 1.5 2.5 -1.6 0.7
Trunk predicted mass 1.6 9.4 11.6 2.7 -3.4
Standing height 6.3 62.8 86.2 9.3 -6.3
Length of working week for main job 0.5 0.5 0.9 0.3 1.0
Exposure to tobacco smoke at home 0.3 0.4 0.6 0.8 0.4
Breastfed as a baby 1.1 1.4 2.5 1.6 -0.5
Tense / ‘highly strung’ 1.2 2.0 4.0 -0.2 -2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.0 0.4 -1.0
Hair/balding pattern: Pattern 4 0.2 0.4 0.7 -0.8 0.2
Birth weight of first child 0.4 0.7 0.7 0.8 0.8
Peak expiratory flow (PEF) 0.2 0.6 0.9 0.9 0.5
Pulse wave reflection index 0.2 0.3 0.6 -0.1 -0.8
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 -0.0 -0.3
Loud music exposure frequency 1.4 1.5 2.6 1.6 0.7
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.8 0.3 -1.7
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 1.6 -0.7 -1.3
Blood clot in the leg (DVT) 0.9 1.2 2.3 1.5 0.1
Medication: Paracetamol 0.2 0.3 0.7 0.8 -0.0
Headache pain in last month 0.4 0.7 1.0 -0.5 -1.0
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.3 0.6 1.1
Glaucoma (self-reported) 9.6 11.2 17.5 4.2 -2.2
Gout (self-reported) 0.1 0.2 0.2 0.4 0.4
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 3.2 1.8 0.9
Medication: Amlodipine 0.8 1.1 2.1 -0.3 1.5
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.9 -0.5 1.4
Birth weight 0.0 0.1 0.1 0.3 -0.1
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.8 -1.7 -0.3
High blood pressure (siblings) 1.6 2.3 4.1 -0.7 2.0
Forced vital capacity (FVC), Best measure 0.8 3.1 6.2 2.5 -0.2
Body fat percentage 0.3 1.3 2.6 -1.6 0.2
Leg fat percentage (right) 0.7 2.4 4.7 -2.2 -0.5
Arm fat-free mass (right) 1.8 9.1 13.8 2.1 -3.7
Exposure to tobacco smoke outside home 1.0 1.3 1.6 -0.9 1.3
Comparative body size at age 10 3.9 10.8 19.5 -4.4 1.4
Number of full brothers 2.6 3.3 5.6 1.0 -2.4
Worry too long after embarrassment 0.6 1.1 2.2 -0.0 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 4.6 6.0 8.1 2.9 -1.9
Wheeze or whistling in the chest in last year 0.2 0.4 0.9 -0.9 0.0
Number of children fathered 0.4 0.5 0.9 -0.2 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.0 -1.0 0.5
Age at first live birth 0.1 0.2 0.4 -0.2 0.6
Pulse wave peak to peak time 0.8 0.9 1.8 -0.0 1.3
Health satisfaction 0.6 0.8 1.0 0.8 1.0
Shortness of breath walking on level ground 0.1 0.1 0.1 0.3 0.3
Qualifications: College or University degree 0.1 0.2 0.4 0.1 0.6
Eye problems/disorders: None of the above 0.8 1.0 1.9 0.1 1.4
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.8 0.1 -1.3
Emphysema/chronic bronchitis 0.2 0.2 0.5 -0.1 0.7
Medication for pain relief, constipation, heartburn 0.6 1.1 1.4 0.9 -1.2
Neck or shoulder pain in last month 0.4 0.5 0.9 -0.4 0.9
Medication: Blood pressure 0.0 0.0 0.0 -0.0 0.1
Angina (self-reported) 0.2 0.2 0.3 0.2 -0.6
Migraine (self-reported) 0.9 1.1 2.0 -0.3 -1.4
Medication: Ibuprofen 1.1 1.3 1.8 1.3 0.9
Medication: Allopurinol 0.6 0.8 1.3 1.1 0.5
Medication: Omeprazole 1.4 1.7 2.6 1.6 0.9
Medication: Seretide 50 evohaler 0.5 0.6 1.2 -1.1 -0.0
Mean time to correctly identify matches 0.3 0.6 0.9 0.5 -1.0
Heart disease (mother) 1.2 1.4 2.8 0.0 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.6 0.8 0.5
Whole body fat mass 0.0 0.2 0.2 -0.4 -0.5
Leg fat mass (right) 0.2 1.0 1.2 -1.1 -0.9
Arm predicted mass (right) 1.7 8.7 12.8 2.1 -3.6
Pulse rate, automated reading 0.1 0.3 0.5 0.7 -0.4
Alcohol intake frequency. 0.4 0.9 1.0 -0.9 -1.0
Comparative height size at age 10 6.9 37.7 56.6 7.5 -4.3
Number of full sisters 0.2 0.3 0.4 0.3 -0.7
Suffer from ‘nerves’ 0.5 0.8 1.6 0.1 -1.2
Overall health rating 0.4 0.8 1.6 1.3 0.1
Chest pain or discomfort 1.1 1.6 2.2 1.5 1.0
Had major operations 1.0 1.2 1.5 -1.0 1.2
Age at last live birth 0.2 0.4 0.6 0.8 0.3
Family relationship satisfaction 0.1 0.1 0.2 -0.4 0.3
Leg pain on walking 3.2 4.1 7.6 2.8 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 1.8 -1.4 -0.5
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.2 0.5 0.4
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 -1.0 -0.2
Medication: Aspirin 0.8 1.0 1.3 -0.9 1.1
Supplements: Vitamin C 0.4 0.4 0.7 -0.8 -0.4
Knee pain experienced in last month 1.5 2.3 4.1 0.8 2.0
Hypertension (Self-reported) 0.1 0.3 0.4 -0.6 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.8 0.9 -0.3
Illnesses of father: Heart disease 0.7 0.9 1.9 0.0 -1.4
Illnesses of siblings: Diabetes 0.1 0.2 0.3 -0.6 -0.1
Smoking status: Previous 0.4 0.6 1.3 -1.1 0.0
Forced expiratory volume in 1-second (FEV1), predicted 2.4 5.0 7.1 2.7 -1.7
Whole body fat-free mass 1.1 6.1 6.5 2.4 -2.5
Leg fat-free mass (right) 0.4 2.0 3.4 1.9 -0.7
Arm fat percentage (left) 1.5 6.1 9.3 -3.1 1.7
Average weekly red wine intake 0.7 1.0 1.5 -1.2 0.7
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.1 0.7 -1.0
Mood swings 0.3 0.5 0.7 -0.8 -0.6
Loneliness, isolation 0.3 0.5 0.8 -0.4 0.9
Long-standing illness, disability or infirmity 0.2 0.3 0.7 0.8 -0.1
Ever had bowel cancer screening 0.8 0.9 1.8 0.4 -1.3
Diabetes diagnosed by doctor 0.4 0.6 0.6 -0.7 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.4 0.2
Friendships satisfaction 1.5 1.9 3.8 -1.9 0.2
Qualifications: nursing, teaching 0.1 0.1 0.2 0.4 -0.2
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.4 -0.3
Eye problems/disorders: Cataract 0.8 0.9 1.4 -1.2 0.7
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 1.2 -1.0 1.1
Medication for cholesterol 0.4 0.7 1.3 -0.1 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 1.9 -1.4 -1.2
Back pain experienced in last month 1.6 2.3 2.3 1.5 1.5
Mineral and other dietary supplements 0.2 0.3 0.4 -0.4 -0.7
Breast cancer (self-reported) 0.1 0.1 0.2 0.0 0.4
Asthma (self-reported) 0.9 1.8 2.5 -1.6 1.0
Osteoporosis (self-reported) 0.4 0.5 0.7 -0.8 0.6
Osteoarthritis (self-reported) 0.0 0.0 0.0 -0.1 -0.1
Medication: Aspirin 0.8 1.1 1.1 -1.0 1.0
Medication: Gliclazide 0.5 0.6 1.1 -1.0 -0.4
Illnesses of father: None of the above (group 1) 0.3 0.3 0.5 -0.7 -0.4
Smoking status: Current 0.5 0.8 0.8 0.9 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.2 -0.1 1.5
Whole body water mass 1.1 6.1 6.3 2.4 -2.5
Leg predicted mass (right) 0.4 2.0 3.5 1.9 -0.7
Arm fat mass (left) 0.4 1.5 2.9 -1.7 0.4
Number of self-reported non-cancer illnesses 0.4 0.7 1.3 1.2 0.2
Average weekly champagne plus white wine intake 0.8 1.1 2.0 0.4 -1.4
Miserableness 0.3 0.5 1.0 -1.0 0.2
Guilty feelings 1.7 2.6 4.9 -2.2 0.5
Wears glasses or contact lenses 4.4 5.1 8.1 -2.9 -1.4
Ever taken oral contraceptive pill 0.9 1.0 1.5 -0.7 1.2
Hearing aid user 0.2 0.2 0.4 -0.6 0.0
Mother’s age at death 1.4 1.7 3.5 0.0 1.9
Financial situation satisfaction 0.5 0.7 1.3 -1.2 0.0
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.6 0.8 0.1
Commuting to job workplace: Public transport 0.1 0.2 0.2 0.3 -0.4
Eye problems/disorders: Glaucoma 5.9 6.9 10.9 3.3 -1.7
Medication: Blood pressure 0.9 1.7 2.4 -1.5 1.0
Pain type(s) experienced in last month: Hip pain 1.4 1.8 2.9 0.8 -1.7
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.5 1.2 0.6
High cholesterol (Self-reported) 0.0 0.1 0.1 -0.0 -0.4
Medication: Bendroflumethiazide 0.7 1.1 1.8 -0.6 -1.4
Medication: Paracetamol 1.4 2.1 4.2 2.0 -0.1
Medication: Lisinopril 2.4 3.1 4.1 1.5 -2.0
Medication: Atorvastatin 0.7 0.9 1.5 0.5 -1.2
Illnesses of father: High blood pressure 0.7 0.9 1.7 1.3 0.4
Alcohol drinker status: Never 0.1 0.1 0.1 -0.3 -0.2
Ever smoked 0.1 0.2 0.4 -0.2 -0.6
Basal metabolic rate 0.9 4.7 5.4 2.0 -2.3
Leg fat percentage (left) 0.5 1.9 3.8 -1.9 -0.1
Arm fat-free mass (left) 1.4 6.9 9.7 2.0 -3.1
Number of operations (self-reported) 0.8 1.2 2.3 -0.3 1.5
Average weekly beer plus cider intake 0.2 0.2 0.3 -0.5 0.4
Irritability 1.1 1.9 3.1 -1.7 -0.9
Risk taking 0.1 0.2 0.3 0.6 0.0
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.0 -0.1 -0.1
Fractured/broken bones in last 5 years 1.5 2.0 3.5 -1.9 0.6
Age started oral contraceptive pill 0.3 0.4 0.8 -0.1 0.9
Diastolic blood pressure, automated reading 0.3 0.9 1.4 -1.2 0.7
Ever depressed for a whole week 0.6 0.8 1.2 -1.1 -0.6
Unable to work because of sickness or disability 0.5 0.7 0.7 0.8 0.8
Commuting to job workplace: Cycle 0.0 0.0 0.0 0.2 -0.0
Myopia 0.6 0.9 1.5 0.6 1.2
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.3 0.6 -0.3
Cholesterol lowering medication 0.0 0.1 0.1 0.3 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 1.2 1.0 1.1
Pain experienced in last month 1.9 3.1 4.0 -2.0 -1.5
Supplements: Calcium 1.0 1.1 1.5 1.2 0.8
Basal cell carcinoma (self-reported) 0.3 0.3 0.5 -0.3 -0.7
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.5 0.5 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.8 1.3 -0.1
Heart disease (siblings) 0.7 0.8 1.2 1.1 -0.7
Alcohol drinker status: Previous 0.6 0.7 1.1 -1.0 0.6
Pack years of smoking 0.4 0.6 1.2 0.1 1.1
Impedance of whole body 1.2 6.0 10.0 3.2 -1.4
Leg fat mass (left) 0.2 0.7 1.0 -1.0 -0.7
Arm predicted mass (left) 1.3 6.8 9.7 2.0 -3.1