TWAS hub - BMP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hippocampus	0.394	0.115	0.0011	0.005	NA	0.043	NA	0.008	0.25	NA	0.036	NA	0.2
2	GTEx	Ovary	0.488	0.121	0.0061	-0.010	NA	0.049	NA	0.021	0.68	NA	0.024	NA	0.1

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Glaucoma (self-reported)	9.6	11.2	17.5	4.2	-2.2
Comparative height size at age 10	6.9	37.7	56.6	7.5	-4.3
Height	6.5	125.2	163.8	12.8	-9.3
Standing height	6.3	62.8	86.2	9.3	-6.3
Eye problems/disorders: Glaucoma	5.9	6.9	10.9	3.3	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	4.6	6.0	8.1	2.9	-1.9
Wears glasses or contact lenses	4.4	5.1	8.1	-2.9	-1.4
Comparative body size at age 10	3.9	10.8	19.5	-4.4	1.4
Waist Hip Ratio (WHR)	3.8	16.9	18.8	3.9	-4.3
Neuroticism (2016)	3.7	5.3	5.8	-2.2	-2.4
Hair/balding pattern: Pattern 3	3.6	5.4	10.8	-3.3	-0.0
Sitting height	3.3	23.4	41.6	6.5	-2.3
Leg pain on walking	3.2	4.1	7.6	2.8	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.9	3.9	5.7	2.4	-1.4
Heel T-Score	2.7	21.3	30.2	-5.5	-3.5
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.1	8.1	-2.0	-2.8
Time employed in main current job	2.7	3.1	6.1	-2.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	2.6	6.0	8.0	-2.8	-2.0
Number of full brothers	2.6	3.3	5.6	1.0	-2.4
Depression (Nagel 2018)	2.5	3.8	5.0	1.6	-2.2
Number of incorrect matches in round	2.5	4.1	6.9	-2.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.4	5.0	7.1	2.7	-1.7
Medication: Lisinopril	2.4	3.1	4.1	1.5	-2.0
Prospective memory result	2.3	2.8	4.8	-0.9	-2.2
Impedance of leg (left)	2.2	10.7	11.2	3.3	-3.2
Impedance of leg (right)	2.1	10.2	12.9	2.8	-3.6
Financial difficulties in last 2 years	2.1	2.8	5.5	-0.0	2.4
Lung FVC	2.0	10.2	12.8	-2.8	3.6
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	2.4	-1.5	-1.6
Had menopause	2.0	2.5	4.2	-2.1	-0.9
Noisy workplace	2.0	2.4	3.7	1.9	-1.1
Hypothyroidism (self reported)	1.9	4.4	6.9	2.6	1.4
Chronotype (morning person)	1.9	4.3	5.9	-1.6	-2.4
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	5.6	2.4	-0.8
Pain experienced in last month	1.9	3.1	4.0	-2.0	-1.5
BMI	1.8	10.3	19.1	-4.4	1.2
Maternal smoking around birth	1.8	2.5	4.7	0.6	2.2
Serious illness, injury or assault to yourself	1.8	2.2	4.2	2.1	0.4
Chronic bronchitis/emphysema (father)	1.8	2.1	3.5	-1.9	0.8
Fluid intelligence score	1.8	3.8	4.2	-1.8	2.1
Forced expiratory volume in 1-second (FEV1)	1.8	5.9	11.8	3.4	0.0
Arm fat-free mass (right)	1.8	9.1	13.8	2.1	-3.7
Supplements: Glucosamine	1.7	2.2	2.3	1.4	1.5
Arm fat percentage (right)	1.7	6.5	8.7	-3.0	2.1
Trunk fat-free mass	1.7	9.5	11.8	2.7	-3.4
Arm predicted mass (right)	1.7	8.7	12.8	2.1	-3.6
Guilty feelings	1.7	2.6	4.9	-2.2	0.5
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	2.0	1.4	-1.2
Trunk predicted mass	1.6	9.4	11.6	2.7	-3.4
High blood pressure (siblings)	1.6	2.3	4.1	-0.7	2.0
Back pain experienced in last month	1.6	2.3	2.3	1.5	1.5
Type 2 Diabetes (T2D) (2012)	1.5	1.7	2.8	1.7	-0.8
Frequency of depressed mood in last 2 weeks	1.5	2.1	2.3	1.3	-1.5
Ever used hormone-replacement therapy (HRT)	1.5	2.0	3.5	-0.7	-1.9
Knee pain experienced in last month	1.5	2.3	4.1	0.8	2.0
Arm fat percentage (left)	1.5	6.1	9.3	-3.1	1.7
Friendships satisfaction	1.5	1.9	3.8	-1.9	0.2
Fractured/broken bones in last 5 years	1.5	2.0	3.5	-1.9	0.6
Body mass index (BMI)	1.4	6.1	10.5	-3.2	1.3
Pulse wave Arterial Stiffness index	1.4	1.6	2.7	0.7	-1.6
Loud music exposure frequency	1.4	1.5	2.6	1.6	0.7
Medication: Omeprazole	1.4	1.7	2.6	1.6	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	1.9	-1.4	-1.2
Mother’s age at death	1.4	1.7	3.5	0.0	1.9
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.9	0.8	-1.7
Medication: Paracetamol	1.4	2.1	4.2	2.0	-0.1
Arm fat-free mass (left)	1.4	6.9	9.7	2.0	-3.1
Alzheimer’s Disease (in mother)	1.3	1.5	2.9	-0.3	-1.7
Systolic blood pressure, automated reading	1.3	3.7	7.5	-2.7	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	8.2	2.9	-0.1
Arm predicted mass (left)	1.3	6.8	9.7	2.0	-3.1
Systolic Blood Pressure	1.2	5.8	6.4	-2.3	2.5
Lung FEV1/FVC ratio	1.2	6.3	11.5	3.4	-1.1
Medication for hormone replacement therapy	1.2	1.4	2.0	1.4	-0.9
Diabetes (father)	1.2	1.5	3.0	-0.2	-1.7
Severe depression (siblings)	1.2	1.3	2.6	-1.6	0.3
Tense / ‘highly strung’	1.2	2.0	4.0	-0.2	-2.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.8	-1.7	-0.3
Heart disease (mother)	1.2	1.4	2.8	0.0	-1.7
Impedance of whole body	1.2	6.0	10.0	3.2	-1.4
Neuroticism (Nagel 2018)	1.1	2.6	4.7	-2.2	-0.7
Neuroticism	1.1	2.8	3.0	-1.7	-1.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.3	-0.4	-1.5
Hair/balding pattern: Pattern 2	1.1	1.4	2.8	1.7	-0.2
Forced vital capacity (FVC)	1.1	4.1	8.0	2.8	-0.5
Mouth/teeth dental problems	1.1	1.6	3.1	0.4	1.8
Breastfed as a baby	1.1	1.4	2.5	1.6	-0.5
Medication: Ibuprofen	1.1	1.3	1.8	1.3	0.9
Chest pain or discomfort	1.1	1.6	2.2	1.5	1.0
Whole body fat-free mass	1.1	6.1	6.5	2.4	-2.5
Whole body water mass	1.1	6.1	6.3	2.4	-2.5
Irritability	1.1	1.9	3.1	-1.7	-0.9
Ulcerative Colitis	1.0	1.5	2.3	0.9	-1.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	1.9	1.4	-0.8
Had other major operations	1.0	1.2	2.0	0.6	1.4
Lung cancer (father)	1.0	1.1	2.0	-1.4	-0.5
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.2	1.8	0.9
Exposure to tobacco smoke outside home	1.0	1.3	1.6	-0.9	1.3
Had major operations	1.0	1.2	1.5	-1.0	1.2
Supplements: Calcium	1.0	1.1	1.5	1.2	0.8
Ever had hysterectomy (womb removed)	0.9	1.0	1.6	-1.3	-0.7
Taking other prescription medications	0.9	1.3	2.6	1.6	0.1
Asthma	0.9	1.9	2.4	-1.6	1.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.8	0.3	-1.7
Blood clot in the leg (DVT)	0.9	1.2	2.3	1.5	0.1
Migraine (self-reported)	0.9	1.1	2.0	-0.3	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.8	-1.4	-0.5
Asthma (self-reported)	0.9	1.8	2.5	-1.6	1.0
Ever taken oral contraceptive pill	0.9	1.0	1.5	-0.7	1.2
Medication: Blood pressure	0.9	1.7	2.4	-1.5	1.0
Basal metabolic rate	0.9	4.7	5.4	2.0	-2.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.2	1.0	1.1
Worry (Nagel 2018)	0.8	1.7	2.8	-0.7	-1.7
Lupus	0.8	1.2	1.5	1.0	1.2
Allergy	0.8	1.8	2.7	0.9	-1.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.6	-0.7	-1.3
Medication: Amlodipine	0.8	1.1	2.1	-0.3	1.5
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.9	-0.5	1.4
Forced vital capacity (FVC), Best measure	0.8	3.1	6.2	2.5	-0.2
Pulse wave peak to peak time	0.8	0.9	1.8	-0.0	1.3
Eye problems/disorders: None of the above	0.8	1.0	1.9	0.1	1.4
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.8	0.1	-1.3
Medication: Aspirin	0.8	1.0	1.3	-0.9	1.1
Ever had bowel cancer screening	0.8	0.9	1.8	0.4	-1.3
Eye problems/disorders: Cataract	0.8	0.9	1.4	-1.2	0.7
Medication: Aspirin	0.8	1.1	1.1	-1.0	1.0
Average weekly champagne plus white wine intake	0.8	1.1	2.0	0.4	-1.4
Number of operations (self-reported)	0.8	1.2	2.3	-0.3	1.5
Blood Eosinophil Count	0.7	5.1	8.1	2.9	1.5
Current tobacco smoking	0.7	1.2	1.2	1.1	-1.1
Medication: Levothyroxine sodium	0.7	1.2	1.5	1.2	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.1	1.5	0.2
Hearing difficulty/problems with background noise	0.7	1.1	2.1	-1.5	0.1
Diabetes (self-reported)	0.7	1.0	1.3	-0.9	-1.1
Medication: Ramipril	0.7	0.8	1.7	1.3	-0.1
Neuroticism score	0.7	1.4	2.2	-1.5	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.4	1.2	-0.4
Medication: Cholesterol lowering	0.7	1.1	2.1	-0.4	-1.4
Depression (self-reported)	0.7	0.9	1.3	1.1	-0.7
Leg fat percentage (right)	0.7	2.4	4.7	-2.2	-0.5
Illnesses of father: Heart disease	0.7	0.9	1.9	0.0	-1.4
Average weekly red wine intake	0.7	1.0	1.5	-1.2	0.7
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.1	0.7	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.2	-1.0	1.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.5	1.2	0.6
Medication: Bendroflumethiazide	0.7	1.1	1.8	-0.6	-1.4
Medication: Atorvastatin	0.7	0.9	1.5	0.5	-1.2
Illnesses of father: High blood pressure	0.7	0.9	1.7	1.3	0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.8	1.3	-0.1
Heart disease (siblings)	0.7	0.8	1.2	1.1	-0.7
Ulcerative Colitis (UC)	0.6	1.1	2.1	1.5	0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.0	-1.4	0.9
Body Mass Index (BMI) (2010)	0.6	0.9	1.5	-1.2	0.5
Mean Putamen Volume	0.6	0.7	1.4	0.2	-1.2
Fed-up feelings	0.6	1.1	2.2	-1.5	0.1
Impedance of arm (right)	0.6	2.9	5.5	2.3	0.6
Alcohol intake versus 10 years previously	0.6	1.0	1.1	0.9	-1.0
Worrier / anxious feelings	0.6	1.2	1.9	-0.6	-1.4
Illnesses of mother	0.6	0.7	1.2	1.1	0.5
Worry too long after embarrassment	0.6	1.1	2.2	-0.0	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.0	-1.0	0.5
Health satisfaction	0.6	0.8	1.0	0.8	1.0
Medication for pain relief, constipation, heartburn	0.6	1.1	1.4	0.9	-1.2
Medication: Allopurinol	0.6	0.8	1.3	1.1	0.5
Ever depressed for a whole week	0.6	0.8	1.2	-1.1	-0.6
Myopia	0.6	0.9	1.5	0.6	1.2
Alcohol drinker status: Previous	0.6	0.7	1.1	-1.0	0.6
Crohns Disease (2012)	0.5	0.8	1.6	0.1	-1.3
Rheumatoid Arthritis	0.5	0.7	1.3	0.4	-1.1
Supplements: Zinc	0.5	0.5	0.8	0.5	0.9
Medication: Metformin	0.5	0.7	1.2	-0.5	-1.1
Townsend deprivation index at recruitment	0.5	0.8	1.4	1.2	-0.2
Average weekly fortified wine intake	0.5	0.6	1.2	-1.1	-0.3
Age when periods started (menarche)	0.5	1.3	2.5	0.3	1.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.8	-0.9	-0.6
Multivitamins +/- minerals	0.5	0.7	1.3	1.1	-0.3
Impedance of arm (left)	0.5	2.4	4.7	2.2	0.2
Length of working week for main job	0.5	0.5	0.9	0.3	1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.3	0.6	1.1
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-1.1	-0.0
Suffer from ‘nerves’	0.5	0.8	1.6	0.1	-1.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-1.0	-0.2
Medication: Gliclazide	0.5	0.6	1.1	-1.0	-0.4
Smoking status: Current	0.5	0.8	0.8	0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.2	-0.1	1.5
Financial situation satisfaction	0.5	0.7	1.3	-1.2	0.0
Leg fat percentage (left)	0.5	1.9	3.8	-1.9	-0.1
Unable to work because of sickness or disability	0.5	0.7	0.7	0.8	0.8
Depressed Affect (Nagel 2018)	0.4	0.9	1.7	-1.3	0.2
Alzheimer’s Disease (in father)	0.4	0.4	0.6	0.5	0.8
Major Depression (MDD)	0.4	0.5	1.0	-1.0	-0.0
Reaction Time	0.4	0.8	1.1	1.0	-0.7
Breast Cancer	0.4	1.0	1.6	-1.3	-0.6
Coronary Artery Disease (CAD)	0.4	0.5	0.9	-0.1	1.0
Allergy or Eczema	0.4	1.0	1.4	-1.2	0.8
Respiratory disease	0.4	0.9	1.4	-1.2	0.6
Diabetes (mother)	0.4	0.5	1.0	-1.0	-0.1
Pack years adult smoking proportion	0.4	0.6	1.2	0.0	1.1
Qualifications: CSEs or equivalent	0.4	0.6	0.7	0.8	0.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.0	-0.9	1.0
Pain all over the body in last month	0.4	0.4	0.8	0.9	-0.3
Father’s age at death	0.4	0.5	0.6	-0.6	0.8
Number of live births	0.4	0.5	0.9	-0.4	1.0
Medication: Lansoprazole	0.4	0.5	1.0	-0.1	-1.0
Arm fat mass (right)	0.4	1.5	2.5	-1.6	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.0	0.4	-1.0
Birth weight of first child	0.4	0.7	0.7	0.8	0.8
Headache pain in last month	0.4	0.7	1.0	-0.5	-1.0
Number of children fathered	0.4	0.5	0.9	-0.2	-1.0
Neck or shoulder pain in last month	0.4	0.5	0.9	-0.4	0.9
Alcohol intake frequency.	0.4	0.9	1.0	-0.9	-1.0
Overall health rating	0.4	0.8	1.6	1.3	0.1
Supplements: Vitamin C	0.4	0.4	0.7	-0.8	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	0.9	-0.3
Smoking status: Previous	0.4	0.6	1.3	-1.1	0.0
Leg fat-free mass (right)	0.4	2.0	3.4	1.9	-0.7
Diabetes diagnosed by doctor	0.4	0.6	0.6	-0.7	-0.8
Medication for cholesterol	0.4	0.7	1.3	-0.1	-1.1
Osteoporosis (self-reported)	0.4	0.5	0.7	-0.8	0.6
Leg predicted mass (right)	0.4	2.0	3.5	1.9	-0.7
Arm fat mass (left)	0.4	1.5	2.9	-1.7	0.4
Number of self-reported non-cancer illnesses	0.4	0.7	1.3	1.2	0.2
Pack years of smoking	0.4	0.6	1.2	0.1	1.1
Ovarian Cancer	0.3	0.3	0.6	-0.8	0.3
Prostate Cancer	0.3	0.4	0.9	-0.9	0.0
HbA1C	0.3	0.3	0.6	0.2	0.8
LDL Cholesterol	0.3	0.5	0.8	0.9	0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.0	-0.3	-1.0
Relative age of first facial hair	0.3	0.7	1.0	1.0	0.6
Vitamin and mineral supplements	0.3	0.4	0.7	-0.4	-0.8
Leg fat-free mass (left)	0.3	1.7	2.4	1.5	-1.0
Hand grip strength (right)	0.3	0.9	1.2	-0.7	1.1
Relative age voice broke	0.3	0.4	0.8	0.9	-0.1
Stomach or abdominal pain in last month	0.3	0.3	0.7	0.8	-0.0
Leg predicted mass (left)	0.3	1.7	2.3	1.5	-1.0
Medication: Simvastatin	0.3	0.4	0.7	0.8	0.4
Weight	0.3	1.6	2.0	1.1	-1.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	-0.1	-1.0
Exposure to tobacco smoke at home	0.3	0.4	0.6	0.8	0.4
Body fat percentage	0.3	1.3	2.6	-1.6	0.2
Mean time to correctly identify matches	0.3	0.6	0.9	0.5	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.6	0.8	0.5
Mood swings	0.3	0.5	0.7	-0.8	-0.6
Loneliness, isolation	0.3	0.5	0.8	-0.4	0.9
Illnesses of father: None of the above (group 1)	0.3	0.3	0.5	-0.7	-0.4
Miserableness	0.3	0.5	1.0	-1.0	0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.8	0.1
Age started oral contraceptive pill	0.3	0.4	0.8	-0.1	0.9
Diastolic blood pressure, automated reading	0.3	0.9	1.4	-1.2	0.7
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	-0.3	-0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.5	0.5	-0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.1	-0.7
Fasting Glucose	0.2	0.2	0.3	0.3	0.6
Blood Platelet Count	0.2	2.2	4.2	2.0	0.5
Hand grip strength (left)	0.2	0.6	1.0	0.5	1.0
Average weekly spirits intake	0.2	0.2	0.3	-0.6	-0.4
Angina	0.2	0.3	0.3	0.6	-0.4
Past tobacco smoking	0.2	0.3	0.5	0.7	0.4
Alcohol usually taken with meals	0.2	0.3	0.5	0.2	0.7
Nervous feelings	0.2	0.4	0.7	0.0	-0.8
Heart attack	0.2	0.3	0.5	0.2	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.3	0.6
Pulse rate	0.2	0.4	0.8	0.1	0.9
Happiness	0.2	0.3	0.5	-0.7	0.2
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	-0.8	0.2
Peak expiratory flow (PEF)	0.2	0.6	0.9	0.9	0.5
Pulse wave reflection index	0.2	0.3	0.6	-0.1	-0.8
Medication: Paracetamol	0.2	0.3	0.7	0.8	-0.0
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	-0.9	0.0
Emphysema/chronic bronchitis	0.2	0.2	0.5	-0.1	0.7
Angina (self-reported)	0.2	0.2	0.3	0.2	-0.6
Leg fat mass (right)	0.2	1.0	1.2	-1.1	-0.9
Number of full sisters	0.2	0.3	0.4	0.3	-0.7
Age at last live birth	0.2	0.4	0.6	0.8	0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.2	0.5	0.4
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.8	-0.1
Mineral and other dietary supplements	0.2	0.3	0.4	-0.4	-0.7
Hearing aid user	0.2	0.2	0.4	-0.6	0.0
Average weekly beer plus cider intake	0.2	0.2	0.3	-0.5	0.4
Leg fat mass (left)	0.2	0.7	1.0	-1.0	-0.7
Bipolar Disorder (2018)	0.1	0.2	0.2	-0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	-0.2	0.7
Crohns Disease (2017)	0.1	0.1	0.2	-0.4	-0.3
Age at First Birth	0.1	0.1	0.1	-0.1	0.4
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.5	-0.0
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.0	0.6
Schizophrenia (2014)	0.1	0.1	0.1	-0.3	0.3
Triglycerides	0.1	0.2	0.4	0.7	-0.1
Blood Red Count	0.1	1.4	2.9	-0.1	1.7
Smoking Status	0.1	0.1	0.2	0.3	-0.4
Cardiovascular Disease	0.1	0.3	0.5	-0.7	0.5
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.7	0.1
Hearing difficulty/problems: Yes	0.1	0.2	0.2	-0.5	-0.3
Medication: Co-codamol	0.1	0.1	0.1	-0.1	-0.4
Trunk fat percentage	0.1	0.4	0.8	-0.9	-0.1
High blood pressure	0.1	0.3	0.4	-0.5	0.6
Medication: Atenolol	0.1	0.1	0.3	-0.0	-0.5
High blood pressure (mother)	0.1	0.2	0.4	0.2	0.6
Trunk fat mass	0.1	0.4	0.8	-0.0	-0.9
Waist circumference	0.1	0.3	0.5	-0.3	-0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	-0.3	-0.5
Qualifications: None of the above	0.1	0.1	0.3	0.5	0.1
Illnesses of siblings	0.1	0.1	0.1	-0.3	-0.2
Hip circumference	0.1	0.4	0.5	-0.6	0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	0.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.0	0.4
Gout (self-reported)	0.1	0.2	0.2	0.4	0.4
Age at first live birth	0.1	0.2	0.4	-0.2	0.6
Shortness of breath walking on level ground	0.1	0.1	0.1	0.3	0.3
Qualifications: College or University degree	0.1	0.2	0.4	0.1	0.6
Pulse rate, automated reading	0.1	0.3	0.5	0.7	-0.4
Family relationship satisfaction	0.1	0.1	0.2	-0.4	0.3
Hypertension (Self-reported)	0.1	0.3	0.4	-0.6	0.5
Illnesses of siblings: Diabetes	0.1	0.2	0.3	-0.6	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.4	0.2
Qualifications: nursing, teaching	0.1	0.1	0.2	0.4	-0.2
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	-0.3
Breast cancer (self-reported)	0.1	0.1	0.2	0.0	0.4
Commuting to job workplace: Public transport	0.1	0.2	0.2	0.3	-0.4
Alcohol drinker status: Never	0.1	0.1	0.1	-0.3	-0.2
Ever smoked	0.1	0.2	0.4	-0.2	-0.6
Risk taking	0.1	0.2	0.3	0.6	0.0
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	0.6	-0.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.3	-0.3
Schizophrenia (2018)	0.0	0.1	0.1	0.1	0.4
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	0.3	0.1
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.2	-0.1
HDL Cholesterol	0.0	0.1	0.1	-0.3	0.3
Blood White Count	0.0	0.0	0.0	0.1	-0.1
Hair Pigment	0.0	0.5	0.7	-0.6	-0.8
Tanning	0.0	0.3	0.6	-0.7	-0.1
Number of treatments/medications taken	0.0	0.0	0.0	-0.0	-0.2
Falls in the last year	0.0	0.1	0.1	0.3	-0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.0	-0.3
Birth weight	0.0	0.1	0.1	0.3	-0.1
Medication: Blood pressure	0.0	0.0	0.0	-0.0	0.1
Whole body fat mass	0.0	0.2	0.2	-0.4	-0.5
Osteoarthritis (self-reported)	0.0	0.0	0.0	-0.1	-0.1
High cholesterol (Self-reported)	0.0	0.1	0.1	-0.0	-0.4
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	-0.1	-0.1
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.2	-0.0
Cholesterol lowering medication	0.0	0.1	0.1	0.3	-0.3

Hub : Genes

BMP2

Models

Trait associations