TWAS hub - BMPR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.0400	0.0200	8.7e-03	0.001	NA	0.006	NA	0.004	2.3e-01	NA	9.0e-02	NA	1.3e-01
2	YFS	Blood	0.0318	0.0097	4.4e-12	0.040	0.039	0.043	0.041	0.045	5.1e-13	6.4e-13	7.2e-14	2.8e-13	1.6e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ever had bowel cancer screening	10.3	12.0	13.9	-3.7	-3.2
Number of full brothers	8.9	11.2	12.7	3.1	3.6
Number of full sisters	8.9	10.9	12.3	3.1	3.5
Qualifications: A levels/AS levels or equivalent	8.7	19.2	23.3	-4.8	-3.9
Fed-up feelings	8.6	15.6	17.9	3.6	4.2
Age at first live birth	8.5	15.0	16.3	-4.0	-3.7
Forced vital capacity (FVC), Best measure	8.1	29.6	30.5	-5.5	-5.4
Townsend deprivation index at recruitment	7.1	10.0	10.9	3.0	3.3
Eye problems/disorders: None of the above	6.6	7.6	8.7	2.5	2.9
Osteoarthritis (self-reported)	6.6	8.6	9.7	2.7	3.1
Forced expiratory volume in 1-second (FEV1), Best measure	6.4	20.4	22.2	-4.3	-4.7
Frequency of unenthusiasm / disinterest in last 2 weeks	6.1	8.2	10.2	2.5	3.2
Forced vital capacity (FVC)	6.1	23.7	26.0	-5.1	-4.6
Alzheimer’s Disease (including proxy)	5.8	8.4	10.5	2.5	3.2
Medication for hormone replacement therapy	5.8	6.5	7.2	2.4	2.7
Forced expiratory volume in 1-second (FEV1), predicted	5.8	12.0	12.0	-3.5	-3.5
Medication: Atorvastatin	5.7	7.0	7.5	2.6	2.7
Depression (Nagel 2018)	5.3	7.9	10.9	2.2	3.3
Glaucoma (self-reported)	5.3	6.3	6.8	-2.4	-2.6
Smoking Status	5.2	12.5	13.8	3.3	3.7
Medication: Cholesterol lowering	5.0	7.8	8.7	2.6	3.0
Verbal and Numeric Reasoning (VNR)	4.9	11.7	15.1	-2.9	-3.9
Lupus	4.9	7.4	10.0	-2.2	-3.2
Illnesses of siblings	4.8	6.7	7.8	-2.8	-2.4
Forced expiratory volume in 1-second (FEV1)	4.5	15.3	15.6	-3.9	-4.0
Arm predicted mass (right)	4.5	23.2	32.9	-3.7	-5.7
Long-standing illness, disability or infirmity	4.5	6.9	9.4	3.1	2.1
Reaction Time	4.2	8.0	9.3	-3.0	-2.6
Diabetes (mother)	4.2	5.4	6.0	2.5	2.2
Asthma	4.1	8.2	8.8	2.7	3.0
Trunk predicted mass	4.1	23.7	31.1	-4.0	-5.6
Arm fat-free mass (right)	4.1	21.1	29.9	-3.5	-5.5
Ever smoked	4.1	7.2	10.3	2.0	3.2
Height	4.0	77.5	82.1	-8.5	-9.1
Trunk fat-free mass	4.0	23.2	30.6	-4.0	-5.5
Asthma (self-reported)	4.0	8.0	8.5	2.7	2.9
Sitting height	3.8	27.0	34.1	-4.5	-5.8
Exposure to tobacco smoke outside home	3.8	5.0	7.0	2.6	1.8
Tinnitus: Yes, now most or all of the time	3.8	4.5	5.6	1.8	2.4
Lung FVC	3.7	19.1	25.3	-5.0	-3.6
Qualifications: O levels/GCSEs or equivalent	3.7	5.9	6.8	-2.6	-2.3
Smoking status: Current	3.7	5.8	6.7	2.2	2.6
Blood Red Count	3.5	33.3	34.7	-5.7	-5.9
Eye problems/disorders: Glaucoma	3.5	4.1	4.2	-2.0	-2.0
Knee pain experienced in last month	3.4	5.3	7.7	1.7	2.8
Depressed Affect (Nagel 2018)	3.3	7.0	7.6	2.5	2.7
Type 2 Diabetes (T2D) (2018)	3.3	6.2	9.4	3.1	1.7
Fluid intelligence score	3.3	6.8	9.7	-2.0	-3.1
Current tobacco smoking	3.2	5.2	5.2	2.3	2.3
Whole body water mass	3.2	18.2	25.3	-3.3	-5.0
Leg fat percentage (left)	3.2	11.7	19.6	4.4	1.9
Heart disease (siblings)	3.2	3.9	5.6	2.4	1.5
Qualifications: None of the above	3.1	6.6	9.2	2.0	3.0
Arm fat percentage (right)	3.1	12.4	20.2	4.5	2.1
Whole body fat-free mass	3.1	17.9	25.3	-3.2	-5.0
Arm fat-free mass (left)	3.1	15.7	21.9	-3.1	-4.7
Leg fat percentage (right)	3.0	10.7	18.8	4.3	1.6
Arm fat percentage (left)	3.0	12.1	20.7	4.5	1.9
Arm predicted mass (left)	3.0	15.4	21.4	-3.0	-4.6
Body fat percentage	2.9	11.5	19.5	4.4	1.9
Frequency of depressed mood in last 2 weeks	2.8	3.9	4.8	1.8	2.2
Lung cancer (father)	2.8	3.3	4.8	2.2	1.4
Miserableness	2.8	4.8	6.1	1.9	2.5
LDL Cholesterol	2.7	4.3	6.4	1.5	2.5
Trunk fat percentage	2.7	10.7	17.8	4.2	1.9
Past tobacco smoking	2.7	5.0	6.7	-1.8	-2.6
Hair/balding pattern: Pattern 2	2.7	3.5	5.3	2.3	1.3
Financial difficulties in last 2 years	2.7	3.6	4.3	2.1	1.7
High cholesterol (Self-reported)	2.7	4.7	6.2	1.8	2.5
Respiratory disease	2.6	5.7	6.6	2.6	2.2
Alcohol usually taken with meals	2.6	4.2	6.1	-1.5	-2.5
Had other major operations	2.6	3.1	3.4	-1.7	-1.8
Pain all over the body in last month	2.6	2.8	2.8	-1.7	-1.7
Time employed in main current job	2.6	2.9	3.2	-1.8	-1.6
Impedance of arm (left)	2.6	12.1	15.7	2.9	4.0
Qualifications: College or University degree	2.6	8.3	9.5	-3.1	-2.7
Mean time to correctly identify matches	2.6	5.0	5.7	-2.4	-2.1
Hearing aid user	2.6	3.0	3.5	1.6	1.9
Medication: Simvastatin	2.5	3.6	5.2	1.4	2.3
Falls in the last year	2.5	3.4	4.1	1.7	2.0
Standing height	2.5	25.1	26.0	-4.9	-5.1
Back pain experienced in last month	2.5	3.6	4.1	-1.8	-2.0
Basal metabolic rate	2.5	14.0	21.7	-2.5	-4.7
Average weekly spirits intake	2.4	3.0	4.8	2.2	1.1
Impedance of arm (right)	2.4	11.1	15.9	2.5	4.0
High blood pressure (siblings)	2.4	3.5	4.4	2.1	1.6
Mouth/teeth dental problems: Mouth ulcers	2.4	3.9	5.1	-1.6	-2.3
Intelligence (Savage-Jansen 2018)	2.3	7.1	8.8	-2.3	-3.0
Pack years adult smoking proportion	2.3	3.4	5.6	2.4	1.1
Comparative height size at age 10	2.3	12.4	12.6	-3.5	-3.5
Alcohol drinker status: Never	2.3	2.7	5.3	-0.4	-2.3
Stomach or abdominal pain in last month	2.2	2.7	3.7	-1.3	-1.9
Had menopause	2.2	2.8	4.1	1.2	2.0
Osteoporosis (self-reported)	2.2	2.7	3.5	-1.9	-1.4
Myopia	2.2	3.2	3.6	-1.7	-1.9
Alzheimer’s Disease (in father)	2.1	2.3	3.0	1.7	1.2
Fasting Glucose	2.1	2.6	4.0	1.1	2.0
Blood White Count	2.1	15.2	18.2	4.3	3.5
Leg fat-free mass (left)	2.1	11.0	17.6	-2.1	-4.2
Medication: Levothyroxine sodium	2.1	3.5	3.7	1.9	1.8
Hypothyroidism/myxoedema (self-reported)	2.1	4.2	4.5	2.0	2.1
Family relationship satisfaction	2.1	2.5	3.5	1.3	1.9
Impedance of whole body	2.1	10.9	14.7	2.7	3.8
Number of operations (self-reported)	2.0	3.0	3.2	-1.8	-1.7
Pain experienced in last month	2.0	3.4	4.0	2.0	1.7
Coronary Artery Disease (CAD)	1.9	2.3	2.9	-1.3	-1.7
Leg predicted mass (left)	1.9	10.2	16.5	-2.0	-4.1
Leg fat-free mass (right)	1.9	10.2	16.0	-2.1	-4.0
Leg predicted mass (right)	1.9	9.9	15.6	-2.1	-4.0
Pack years of smoking	1.9	2.7	4.5	2.1	1.0
Neuroticism	1.8	4.2	7.5	1.0	2.7
Average weekly fortified wine intake	1.8	2.1	3.2	-1.0	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.1	2.3	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	2.6	-1.2	-1.6
Commuting to job workplace: Walk	1.8	1.9	2.8	1.0	1.7
Neuroticism (Nagel 2018)	1.7	4.0	5.9	1.4	2.4
Alzheimer’s Disease (in mother)	1.7	2.0	3.0	1.0	1.7
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	3.8	2.0	0.8
Hand grip strength (right)	1.7	4.7	5.9	-1.9	-2.4
Age at last live birth	1.7	2.5	3.0	-1.4	-1.7
Guilty feelings	1.7	2.5	3.2	1.4	1.8
Serious illness, injury or assault to yourself	1.6	2.0	2.3	1.5	1.3
Chronic bronchitis/emphysema (mother)	1.6	1.9	2.8	1.7	0.9
Illnesses of siblings: Diabetes	1.6	1.9	2.4	1.6	1.2
Ever taken oral contraceptive pill	1.6	1.8	2.6	-1.6	-1.0
Hypothyroidism (self reported)	1.5	3.4	3.7	1.9	1.8
Impedance of leg (left)	1.5	7.3	10.2	2.1	3.2
Allergy	1.5	3.6	6.2	-0.9	-2.5
Comparative body size at age 10	1.5	4.2	6.2	-1.5	-2.5
Breast cancer (self-reported)	1.5	1.8	3.6	-1.9	-0.4
Taking other prescription medications	1.4	2.2	3.1	1.8	1.1
Supplements: Glucosamine	1.4	1.9	2.0	1.4	1.3
Illnesses of mother	1.4	1.7	1.8	-1.3	-1.3
Diabetes diagnosed by doctor	1.4	2.3	4.1	2.0	0.8
Eye problems/disorders: Cataract	1.4	1.6	2.3	-1.5	-0.9
Diabetes (self-reported)	1.3	2.1	3.5	1.9	0.8
Depression (self-reported)	1.3	1.6	2.2	1.5	1.0
Headache pain in last month	1.3	2.3	3.3	-1.1	-1.8
Health satisfaction	1.3	1.7	2.2	1.5	1.1
Medication: Seretide 50 evohaler	1.3	1.5	3.0	1.7	0.1
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	1.8	1.1	1.3
Supplements: Vitamin C	1.3	1.5	2.4	-0.8	-1.5
Irritability	1.3	2.1	3.1	1.1	1.8
Ovarian Cancer	1.2	1.7	2.6	-0.8	-1.6
Triglycerides	1.2	1.9	2.3	1.5	1.2
Blood Eosinophil Count	1.2	9.1	10.6	3.2	2.8
Hearing difficulty/problems: Yes	1.2	1.8	2.2	1.2	1.5
Hair/balding pattern: Pattern 3	1.2	1.8	2.3	-1.5	-1.2
Pulse wave reflection index	1.2	1.5	2.4	0.7	1.6
Gout (self-reported)	1.2	1.6	2.2	1.0	1.5
Unable to work because of sickness or disability	1.2	1.5	2.6	1.6	0.7
Chronotype (morning person)	1.1	2.7	4.2	-1.1	-2.0
Shortness of breath walking on level ground	1.1	1.3	1.8	0.9	1.3
Medication: Omeprazole	1.1	1.3	1.8	-1.3	-0.9
Mood swings	1.1	2.0	2.4	1.3	1.5
Loneliness, isolation	1.1	1.5	1.8	1.1	1.3
Fractured/broken bones in last 5 years	1.1	1.5	2.1	-1.4	-0.9
Crohns Disease (2012)	1.0	1.6	1.7	-1.2	-1.3
Number of treatments/medications taken	1.0	1.9	3.2	1.8	0.7
Relative age of first facial hair	1.0	2.1	3.7	0.6	1.9
Ever used hormone-replacement therapy (HRT)	1.0	1.3	1.8	0.9	1.3
Impedance of leg (right)	1.0	5.0	6.8	1.8	2.6
Qualifications: CSEs or equivalent	1.0	1.3	2.7	1.6	0.1
Neuroticism score	1.0	2.0	3.0	1.0	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	1.8	1.2	1.4
Medication: Paracetamol	1.0	1.7	2.6	1.6	0.9
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.3	0.3	-1.5
Ever depressed for a whole week	1.0	1.3	2.3	-0.5	-1.5
Schizophrenia (2018)	0.9	1.9	2.1	1.4	1.3
Crohns Disease (2017)	0.9	2.0	2.5	-1.6	-1.2
Age at First Birth	0.9	1.3	1.3	-1.1	-1.1
Primary Biliary Cirrhosis	0.9	1.3	2.1	1.5	0.7
Hand grip strength (left)	0.9	2.3	2.5	-1.6	-1.4
Trunk fat mass	0.9	3.7	7.4	2.7	0.1
Number of incorrect matches in round	0.9	1.5	2.8	-1.7	-0.5
Peak expiratory flow (PEF)	0.9	2.1	2.5	-1.3	-1.6
Alcohol intake frequency.	0.9	2.2	4.2	2.1	0.3
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.3	-1.1	-1.0
Allergy or Eczema	0.8	2.1	3.7	0.7	1.9
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	1.9	0.1	1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.7	1.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.8	0.1	-2.0
Weight	0.8	3.9	7.7	-0.1	-2.8
Pulse wave peak to peak time	0.8	0.9	1.0	-1.0	-0.9
Leg fat mass (right)	0.8	3.1	5.9	2.4	-0.5
Friendships satisfaction	0.8	0.9	1.1	1.0	0.9
Leg fat mass (left)	0.8	3.2	6.2	2.5	-0.3
Rheumatoid Arthritis	0.7	1.0	1.2	1.1	0.9
Lung FEV1/FVC ratio	0.7	3.5	3.8	1.9	1.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.4	0.2	-1.2
Age when periods started (menarche)	0.7	1.6	2.5	-1.6	-0.8
Arm fat mass (right)	0.7	2.7	5.4	2.3	-0.1
Breastfed as a baby	0.7	0.8	1.5	0.4	1.2
Blood clot in the leg (DVT)	0.7	0.9	1.8	-1.3	-0.3
Birth weight	0.7	1.5	2.3	-1.5	-0.8
Worry too long after embarrassment	0.7	1.2	1.9	-1.4	0.7
Whole body fat mass	0.7	3.1	6.1	2.5	-0.1
Pulse rate, automated reading	0.7	2.4	4.8	2.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	1.5	-1.2	-1.2
Arm fat mass (left)	0.7	2.9	5.7	2.4	-0.2
Breast Cancer	0.6	1.4	2.7	0.2	-1.6
Neuroticism (2016)	0.6	0.9	1.4	1.2	0.7
BMI	0.6	3.2	6.5	2.5	0.0
Supplements: Zinc	0.6	0.7	1.2	1.1	0.4
Diabetes (father)	0.6	0.8	0.9	0.9	0.8
Maternal smoking around birth	0.6	0.9	1.0	1.0	0.9
Body mass index (BMI)	0.6	2.6	5.1	2.3	-0.4
Hearing difficulty/problems with background noise	0.6	1.0	1.2	0.9	1.1
Pulse rate	0.6	1.0	1.3	1.1	-0.9
Tense / ‘highly strung’	0.6	1.0	1.7	-1.3	-0.5
Wheeze or whistling in the chest in last year	0.6	1.1	1.3	1.0	1.1
Leg pain on walking	0.6	0.7	1.3	0.4	1.1
Average weekly champagne plus white wine intake	0.6	0.8	1.4	-1.2	-0.5
Age started oral contraceptive pill	0.6	0.8	1.6	-1.2	-0.2
Diastolic blood pressure, automated reading	0.6	1.7	1.8	1.4	1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.4	-1.2	-0.3
Prostate Cancer	0.5	0.6	0.7	0.8	0.9
HbA1C	0.5	0.5	0.7	-0.8	-0.6
Schizophrenia (2014)	0.5	1.1	1.5	1.2	0.8
Sensitivity / hurt feelings	0.5	0.8	1.5	0.3	1.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.3	0.2	1.5
Medication: Atenolol	0.5	0.7	0.9	-0.9	-0.7
Hip circumference	0.5	2.2	4.4	0.1	-2.1
Happiness	0.5	0.6	0.9	0.5	1.0
Prospective memory result	0.5	0.6	1.3	-1.1	0.0
Loud music exposure frequency	0.5	0.6	1.1	-0.2	1.0
Medication: Allopurinol	0.5	0.6	0.7	0.7	0.8
Wears glasses or contact lenses	0.5	0.6	0.8	0.9	0.6
Financial situation satisfaction	0.5	0.6	0.9	0.5	1.0
Medication: Bendroflumethiazide	0.5	0.8	1.1	-0.8	-1.0
Alcohol drinker status: Previous	0.5	0.5	0.9	0.9	0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	1.3	0.9	1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.0	1.0	0.1
Waist Hip Ratio (WHR)	0.4	1.8	2.0	1.3	1.4
Ever had hysterectomy (womb removed)	0.4	0.4	0.7	-0.8	-0.4
High blood pressure	0.4	1.0	1.2	-0.9	-1.1
Mouth/teeth dental problems	0.4	0.6	1.0	-0.5	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	-0.9	-0.4
Medication: Blood pressure	0.4	0.7	0.9	-0.8	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	-0.2	0.9
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.9	0.4
Cholesterol lowering medication	0.4	0.5	0.7	0.6	0.8
Irritable Bowel Disease (IBD)	0.3	0.8	0.9	-1.0	-0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	0.8	0.3
Heel T-Score	0.3	2.7	5.4	2.3	-0.2
Multivitamins +/- minerals	0.3	0.4	0.6	0.8	-0.3
Waist circumference	0.3	1.0	1.5	1.2	-0.6
Medication: Ramipril	0.3	0.3	0.6	-0.3	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	0.8	0.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	-0.2	-0.8
Mouth/teeth dental problems: Dentures	0.3	0.4	0.5	0.6	-0.7
Pulse wave Arterial Stiffness index	0.3	0.3	0.4	0.7	0.5
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	0.2	1.3
Medication: Amlodipine	0.3	0.5	0.8	-0.4	-0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	-0.9	-0.1
Medication: Aspirin	0.3	0.4	0.4	-0.7	-0.5
Hypertension (Self-reported)	0.3	0.9	1.1	-0.9	-1.0
Smoking status: Previous	0.3	0.5	0.7	0.4	0.9
Medication: Gliclazide	0.3	0.3	0.3	-0.6	0.5
Medication: Blood pressure	0.3	0.7	0.8	-0.7	-0.9
Medication: Paracetamol	0.3	0.5	0.9	1.0	0.3
Illnesses of father: High blood pressure	0.3	0.4	0.4	0.6	0.7
Bipolar Disorder (2011)	0.2	0.2	0.3	0.2	-0.6
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	0.1
Mean Putamen Volume	0.2	0.2	0.4	-0.6	-0.2
Systolic Blood Pressure	0.2	0.9	1.3	-0.6	1.1
Systolic blood pressure, automated reading	0.2	0.5	0.9	-0.2	1.0
Vitamin and mineral supplements	0.2	0.3	0.5	-0.7	0.3
Medication: Metformin	0.2	0.3	0.4	0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.5	0.7	-0.7
High blood pressure (mother)	0.2	0.3	0.6	0.8	-0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	0.6	0.3
Heart attack	0.2	0.3	0.5	0.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.5	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.0	-0.7
Number of children fathered	0.2	0.2	0.4	0.7	0.1
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.0	-0.6
Medication: Ibuprofen	0.2	0.2	0.3	-0.5	-0.5
Heart disease (mother)	0.2	0.2	0.4	-0.1	-0.7
Suffer from ‘nerves’	0.2	0.3	0.6	0.8	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.4	-0.6	-0.4
Medication for cholesterol	0.2	0.4	0.4	-0.5	-0.6
Medication: Aspirin	0.2	0.2	0.3	-0.6	-0.4
Number of self-reported non-cancer illnesses	0.2	0.3	0.4	0.6	0.4
Mother’s age at death	0.2	0.2	0.3	-0.4	-0.5
Risk taking	0.2	0.3	0.4	-0.6	0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	-0.6	-0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.1	0.8
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.4	0.2
Major Depression (MDD)	0.1	0.1	0.2	0.4	0.3
HDL Cholesterol	0.1	0.2	0.3	-0.1	0.6
Blood Platelet Count	0.1	1.7	2.8	0.8	-1.7
Cardiovascular Disease	0.1	0.4	0.5	0.7	0.6
Medication: Co-codamol	0.1	0.1	0.2	0.2	-0.5
Relative age voice broke	0.1	0.2	0.4	-0.6	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.1	-0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.3	0.5
Worrier / anxious feelings	0.1	0.2	0.4	-0.6	0.3
Noisy workplace	0.1	0.2	0.2	0.4	0.4
Medication: Lansoprazole	0.1	0.1	0.1	-0.4	-0.2
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.0	0.4
Birth weight of first child	0.1	0.2	0.2	-0.3	0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.5	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.1	0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.1	-0.4
Angina (self-reported)	0.1	0.1	0.1	0.3	-0.3
Illnesses of father: Heart disease	0.1	0.2	0.2	0.4	-0.4
Average weekly red wine intake	0.1	0.1	0.2	0.1	0.5
Qualifications: nursing, teaching	0.1	0.1	0.1	0.3	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.1	-0.4
Mineral and other dietary supplements	0.1	0.2	0.3	-0.5	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.2	0.5
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.1	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.6	0.0
Medication: Lisinopril	0.1	0.1	0.2	-0.1	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	0.5	0.6
Supplements: Calcium	0.1	0.1	0.2	-0.1	-0.5
Worry (Nagel 2018)	0.0	0.1	0.1	-0.3	0.2
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.3	0.2
Ulcerative Colitis	0.0	0.0	0.1	0.0	0.3
Hair Pigment	0.0	0.3	0.5	-0.1	-0.7
Tanning	0.0	0.3	0.5	-0.4	0.7
Angina	0.0	0.1	0.1	0.3	-0.2
Severe depression (siblings)	0.0	0.0	0.1	-0.0	0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.1	-0.0
Nervous feelings	0.0	0.1	0.1	-0.3	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	0.3	0.2
Father’s age at death	0.0	0.1	0.1	0.3	0.1
Number of live births	0.0	0.0	0.0	0.1	-0.0
Length of working week for main job	0.0	0.0	0.0	-0.2	0.0
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.0	-0.2
Neck or shoulder pain in last month	0.0	0.0	0.0	0.2	-0.1
Migraine (self-reported)	0.0	0.0	0.1	-0.3	-0.1
Overall health rating	0.0	0.1	0.2	0.4	-0.1
Chest pain or discomfort	0.0	0.0	0.1	0.1	-0.3
Had major operations	0.0	0.0	0.1	0.3	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.2	-0.2
Average weekly beer plus cider intake	0.0	0.0	0.1	-0.2	-0.2
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.0	-0.1	0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	0.3	-0.1

Hub : Genes

BMPR2

Models

Trait associations