Hub : Genes

BRCA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.0560	0.0320	0.00740	0.005	NA	0.003	NA	0.002	1.6e-01	NA	1.9e-01	NA	2.4e-01
2	GTEx	Liver	0.1150	0.0610	0.00880	0.056	NA	0.007	NA	0.032	1.1e-02	NA	2.0e-01	NA	4.5e-02
3	YFS	Blood	0.0650	0.0165	0.00000	0.143	0.145	0.140	0.146	0.141	1.7e-44	4.2e-45	1.4e-43	2.1e-45	7.7e-44
4	TCGA	Cervical Squamous Cell Carcinoma	0.0520	0.0370	0.00800	0.003	0.022	-0.001	NA	0.003	2.3e-01	2.7e-02	3.8e-01	NA	2.1e-01
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0564	0.0398	0.00053	0.011	0.026	0.022	NA	0.022	1.9e-02	5.1e-04	1.6e-03	NA	1.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	1.3	1.1	-0.4	0.1	0.2	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	1.6	0.8	-1.2	1.1	1.2	0.5
Depressed Affect (Nagel 2018)	0.1	0.1	0.6	-0.8	-0.1	0.1	-0.0	0.1
Depression (Nagel 2018)	0.3	0.4	1.4	1.2	-0.6	0.4	0.2	-0.3
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.9	-0.2	1.2	-1.4	-1.2	-0.4
Neuroticism (Nagel 2018)	0.3	0.7	1.3	-0.1	-0.6	1.0	0.9	1.2
Schizophrenia (2018)	0.6	1.3	1.8	0.1	-1.3	1.3	1.3	1.0
Schizophrenia vs Biploar Disorder	1.4	1.8	3.2	0.7	-1.0	1.6	1.4	1.8
Worry (Nagel 2018)	1.8	3.8	6.3	0.5	-1.8	2.2	2.1	2.5
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.3	-0.1	0.2	0.2	0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.7	-0.8	0.2	0.1	-0.3	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.6	0.1	0.0	-0.1	-0.3
Crohns Disease (2017)	1.4	3.0	6.5	-2.5	1.6	-1.8	-1.2	-1.2
Irritable Bowel Disease (IBD)	0.7	1.7	3.8	-1.9	1.4	-1.2	-0.9	-0.9
Ulcerative Colitis (UC)	0.1	0.2	0.6	-0.4	0.8	-0.4	-0.4	-0.3
Major Depression (MDD)	0.5	0.7	1.5	-0.0	-0.7	0.8	0.8	1.2
Reaction Time	0.3	0.6	2.1	1.4	-0.1	0.1	-0.2	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.8	2.2	-1.0	1.5	-1.5	-1.5	-1.1
Breast Cancer	0.4	1.1	2.5	-0.2	1.2	-0.8	-0.8	-1.6
Ovarian Cancer	1.1	1.4	2.0	1.1	-1.1	1.4	1.1	1.2
Prostate Cancer	0.4	0.5	1.0	-1.0	0.8	-0.5	-0.5	0.5
Age at First Birth	0.0	0.0	0.1	0.1	-0.2	0.1	0.2	0.1
Bipolar Disorder (2011)	0.7	0.7	1.0	0.6	-0.8	0.8	1.0	0.9
Body Mass Index (BMI) (2010)	2.9	4.0	6.8	-2.6	2.0	-1.7	-1.9	-1.5
Coronary Artery Disease (CAD)	1.2	1.4	2.2	0.2	-1.5	1.2	1.3	1.3
Crohns Disease (2012)	1.1	1.7	3.2	-1.8	1.1	-1.2	-1.0	-1.3
Mean Putamen Volume	0.3	0.4	0.9	0.6	-0.5	0.9	0.6	-0.1
Fasting Glucose	1.2	1.5	2.5	1.1	-0.9	1.5	1.6	0.9
HbA1C	3.9	4.3	5.6	1.8	-2.0	2.4	2.4	1.9
HDL Cholesterol	1.7	2.8	7.1	-2.7	1.3	-1.6	-1.2	-1.1
LDL Cholesterol	0.3	0.4	0.6	-0.8	0.3	-0.8	-0.7	-0.4
Lupus	2.6	4.0	4.3	1.8	-1.9	2.1	2.1	2.1
Neuroticism (2016)	1.0	1.4	2.3	1.1	-1.1	1.1	1.0	1.5
Primary Biliary Cirrhosis	0.2	0.2	0.5	0.0	-0.6	0.5	0.4	0.7
Rheumatoid Arthritis	0.3	0.4	0.6	0.4	-0.6	0.7	0.6	0.7
Schizophrenia (2014)	2.5	5.5	6.8	1.5	-2.5	2.6	2.6	2.4
Triglycerides	2.9	4.8	12.0	3.5	-1.6	2.2	1.8	1.1
Type 2 Diabetes (T2D) (2012)	1.5	1.8	2.8	0.8	-1.2	1.7	1.6	1.1
Ulcerative Colitis	0.1	0.2	0.8	-0.9	0.1	-0.1	-0.1	-0.5
Blood Eosinophil Count	2.0	15.4	20.2	-4.5	4.5	-3.6	-4.0	-2.7
Blood Platelet Count	0.0	0.2	0.4	-0.7	-0.3	0.1	-0.4	-0.5
Blood Red Count	0.0	0.3	0.7	-0.1	-0.6	0.9	0.7	0.1
Blood White Count	4.6	33.8	39.9	-5.7	6.1	-5.3	-6.3	-5.6
Heel T-Score	2.8	22.0	31.4	4.7	-5.6	5.1	4.3	3.5
BMI	1.9	11.1	19.0	-4.4	3.2	-2.5	-3.2	-3.0
Height	0.0	0.5	1.2	0.1	1.1	0.0	-0.9	0.6
Waist Hip Ratio (WHR)	0.2	1.1	2.8	1.7	-1.1	0.5	0.2	-1.1
Systolic Blood Pressure	1.0	4.8	7.8	1.4	-2.0	2.2	2.2	2.8
Smoking Status	1.6	3.7	4.3	1.9	-2.0	1.9	1.8	2.1
Allergy or Eczema	0.0	0.1	0.3	0.1	0.1	-0.4	-0.3	-0.6
Cardiovascular Disease	0.7	2.4	3.6	1.9	-1.4	1.8	1.3	1.2
Hypothyroidism (self reported)	0.8	1.9	3.6	0.4	-1.1	1.3	1.6	1.9
Respiratory disease	0.2	0.4	0.7	-0.8	0.6	-0.8	-0.6	-0.4
Type 2 Diabetes (T2D) (2018)	0.5	0.8	1.4	0.5	-0.8	1.2	0.8	1.1
Lung FEV1/FVC ratio	0.7	3.7	5.2	-0.4	2.2	-1.8	-2.2	-2.3
Lung FVC	0.1	0.7	1.1	1.1	-0.7	0.7	0.9	0.8
Neuroticism	0.3	0.8	1.1	-0.1	-0.9	1.0	1.0	1.1
Chronotype (morning person)	0.3	0.6	2.5	1.6	-0.3	0.4	0.4	-0.2
Hair Pigment	0.0	0.1	0.2	0.5	-0.5	0.5	0.2	0.0
Tanning	0.2	2.5	3.2	1.7	-1.5	1.2	1.8	1.7
Hand grip strength (left)	4.6	12.2	14.9	2.6	-3.5	3.9	3.7	3.7
Number of treatments/medications taken	0.8	1.4	1.7	1.2	-1.3	0.9	1.3	1.2
Average weekly spirits intake	0.7	0.9	2.3	1.5	-0.7	0.9	0.8	0.6
Sensitivity / hurt feelings	0.6	1.1	1.5	0.3	-1.2	1.2	1.2	1.0
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.6	-0.0	-0.3	-0.1	-0.2
Hearing difficulty/problems: Yes	0.5	0.7	1.7	-0.3	0.5	-0.9	-0.8	-1.3
Relative age of first facial hair	0.5	1.1	1.7	1.1	-1.3	1.3	0.9	0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	1.4	-0.9	0.8	0.8	0.7
Ever used hormone-replacement therapy (HRT)	6.2	7.9	8.9	-2.5	2.9	-2.7	-3.0	-3.0
Ever had hysterectomy (womb removed)	1.5	1.7	2.2	-1.3	1.5	-1.4	-1.4	-0.8
Systolic blood pressure, automated reading	0.0	0.1	0.2	-0.3	0.1	-0.1	-0.1	0.4
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.9	1.4	-0.8	0.9	0.8	1.0
Angina	0.2	0.3	0.6	0.3	-0.3	0.6	0.4	0.8
Medication for hormone replacement therapy	0.2	0.2	1.0	-1.0	0.2	0.0	0.0	-0.1
Vitamin and mineral supplements	4.0	5.4	7.8	-1.3	2.3	-2.3	-2.6	-2.8
Supplements: Zinc	5.2	5.7	6.5	2.1	-2.5	2.4	2.5	2.4
Medication: Co-codamol	0.0	0.0	0.1	-0.2	0.1	0.2	-0.3	0.0
Medication: Metformin	0.6	0.9	2.0	0.0	-0.9	1.4	0.7	1.1
Diabetes (father)	0.3	0.3	1.0	0.1	-0.3	0.5	0.5	1.0
Diabetes (mother)	0.1	0.2	0.3	-0.2	0.5	-0.5	-0.5	-0.2
Severe depression (siblings)	5.8	6.5	10.0	3.2	-2.5	2.4	2.6	2.0
Pack years adult smoking proportion	0.3	0.4	0.7	0.8	-0.6	0.7	0.7	0.5
Impedance of leg (right)	1.0	5.0	7.6	1.4	-2.5	2.1	2.3	2.8
Leg fat-free mass (left)	0.7	3.9	5.6	-1.6	2.4	-1.6	-2.3	-1.8
Trunk fat percentage	1.9	7.8	9.9	-2.9	2.7	-2.2	-3.1	-2.9
Hand grip strength (right)	6.3	17.2	21.9	2.8	-4.2	4.5	4.4	4.7
Townsend deprivation index at recruitment	0.7	1.1	2.4	-0.8	0.8	-1.0	-0.7	-1.6
Current tobacco smoking	0.2	0.3	0.8	0.9	-0.4	0.3	0.4	0.4
Average weekly fortified wine intake	6.1	7.1	10.7	3.3	-2.8	2.7	2.5	1.8
Maternal smoking around birth	0.0	0.0	0.1	0.1	-0.1	0.3	0.2	-0.1
Fed-up feelings	0.1	0.2	0.4	0.0	0.2	-0.4	-0.7	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.6	-0.6	1.1	-1.1	-1.4	-1.9
Relative age voice broke	2.8	4.3	5.7	2.1	-2.4	2.2	1.9	1.6
Taking other prescription medications	0.3	0.5	0.8	0.1	-0.9	0.7	0.8	0.7
Age when periods started (menarche)	0.6	1.4	2.3	0.6	-1.1	1.4	1.5	1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.0	0.2	-0.4	-0.4	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.7	1.3	-1.1	1.0	0.4	-0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.5	0.4	-0.3	0.4	0.3	1.2
Qualifications: CSEs or equivalent	2.3	3.0	3.9	1.1	-2.0	1.9	1.8	1.8
Serious illness, injury or assault to yourself	0.6	0.7	1.0	-0.7	0.8	-0.7	-0.8	-1.0
High blood pressure	0.2	0.5	1.3	0.4	0.7	-0.6	-0.8	-1.1
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.1	-0.3	-0.0	0.1	-0.1
Multivitamins +/- minerals	0.2	0.3	0.8	0.1	-0.4	0.3	0.6	0.9
Stomach or abdominal pain in last month	0.2	0.2	0.6	0.8	-0.4	0.3	0.2	-0.1
Supplements: Glucosamine	1.5	1.9	2.3	-1.0	1.5	-1.5	-1.5	-1.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	0.1	-0.5	0.6	0.6	0.9
Medication: Atenolol	0.2	0.2	0.8	-0.4	0.2	0.1	0.2	0.9
Medication: Levothyroxine sodium	0.3	0.4	1.3	-0.7	-0.1	0.3	0.4	1.1
Sitting height	1.0	6.8	9.6	-2.3	3.1	-2.6	-3.0	-1.9
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.3	-0.0	-0.0	0.1	0.2
High blood pressure (mother)	0.5	0.6	1.0	-0.5	0.7	-1.0	-0.8	-1.0
Body mass index (BMI)	1.6	6.9	8.2	-2.9	2.6	-2.1	-2.7	-2.8
Impedance of leg (left)	1.0	5.0	6.5	1.5	-2.5	2.1	2.4	2.5
Leg predicted mass (left)	0.7	3.9	5.6	-1.7	2.4	-1.6	-2.3	-1.8
Trunk fat mass	1.8	7.8	10.3	-2.8	2.9	-2.2	-3.2	-2.8
Waist circumference	2.0	7.3	10.5	-2.2	2.6	-2.3	-3.0	-3.2
Number of incorrect matches in round	0.9	1.5	1.8	0.4	-1.3	1.3	1.4	1.3
Past tobacco smoking	0.6	1.1	3.0	-1.7	1.0	-0.9	-0.6	-0.1
Alcohol usually taken with meals	0.4	0.6	1.9	-0.9	0.1	0.2	0.5	1.4
Nervous feelings	0.1	0.2	0.3	-0.5	0.5	-0.3	-0.5	0.3
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	3.7	1.8	-1.9	1.8	1.8	1.9
Hearing difficulty/problems with background noise	1.1	1.8	4.2	-0.5	1.0	-1.4	-1.3	-2.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.0	1.0	-0.8	0.8	0.8	0.4
Had menopause	12.2	15.2	18.4	-3.5	4.3	-4.1	-4.2	-3.3
Had other major operations	0.1	0.1	0.5	0.7	-0.3	0.2	0.0	-0.2
Forced vital capacity (FVC)	0.3	1.3	2.2	1.2	-0.9	1.2	0.8	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.6	1.6	-1.5	1.3	0.8	0.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	0.1	-0.1	0.1	0.2	0.1
Qualifications: None of the above	0.5	1.1	2.3	-0.7	0.8	-0.9	-1.1	-1.5
Financial difficulties in last 2 years	0.4	0.5	0.6	-0.6	0.7	-0.7	-0.7	-0.8
Mouth/teeth dental problems	0.1	0.2	0.6	0.5	-0.1	0.0	0.4	0.8
Heart attack	0.8	1.1	1.5	0.4	-1.2	1.2	1.1	1.1
Allergy	0.0	0.1	0.2	-0.3	0.3	0.1	0.0	0.4
Pain all over the body in last month	0.1	0.2	0.5	-0.7	0.3	-0.3	-0.2	0.3
Diabetes (self-reported)	0.2	0.3	0.6	0.2	-0.5	0.7	0.4	0.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.2	-1.3	1.3	-1.5	-1.0	-0.8
Medication: Ramipril	3.3	4.2	5.2	-1.8	2.2	-2.0	-2.3	-2.0
Medication: Simvastatin	0.1	0.1	0.2	0.4	0.2	-0.1	-0.3	-0.3
Fluid intelligence score	0.0	0.1	0.1	-0.3	0.3	-0.3	-0.1	0.3
Illnesses of siblings	0.2	0.3	0.8	0.5	-0.3	0.1	0.6	0.9
Neuroticism score	0.1	0.2	0.5	-0.7	-0.1	0.1	0.2	0.6
Weight	1.2	6.1	7.6	-2.4	2.7	-2.0	-2.8	-2.4
Impedance of arm (right)	0.2	1.1	1.7	1.0	-1.0	1.0	0.9	1.3
Arm fat percentage (right)	1.6	6.5	8.0	-2.8	2.5	-2.0	-2.8	-2.6
Trunk fat-free mass	0.1	0.9	1.8	-0.8	1.3	-0.8	-1.1	-0.4
Hip circumference	1.3	5.4	7.0	-2.6	2.6	-2.0	-2.5	-1.8
Time employed in main current job	0.5	0.6	1.0	0.2	0.9	-1.0	-0.9	-0.6
Alcohol intake versus 10 years previously	0.4	0.6	0.9	0.6	-0.9	0.9	0.7	0.7
Father’s age at death	0.1	0.2	0.4	0.7	0.2	-0.1	-0.1	0.5
Worrier / anxious feelings	2.4	4.6	6.3	1.6	-2.2	2.2	2.2	2.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.7	1.3	-1.3	0.7	1.1	0.7
Falls in the last year	1.8	2.4	5.4	1.0	-1.3	1.4	1.4	2.3
Hair/balding pattern: Pattern 3	0.5	0.8	1.3	0.7	0.8	-0.8	-1.1	-0.9
Number of live births	0.2	0.3	0.7	-0.5	0.2	-0.4	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.0	1.3	-0.9	1.3	0.9	1.4
Pulse rate	0.5	0.8	1.4	1.2	-1.0	0.9	0.8	0.5
Happiness	2.0	2.4	3.5	-0.6	1.6	-1.7	-1.7	-1.9
Noisy workplace	0.2	0.2	0.9	-0.2	-0.1	-0.1	-0.2	-0.9
Qualifications: A levels/AS levels or equivalent	2.3	5.1	7.2	-2.7	2.6	-2.5	-2.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.0	1.0	-0.1	-0.0	-0.1	0.0
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.7	-0.5	0.7	0.2	-0.1
Asthma	0.0	0.1	0.2	-0.0	0.2	-0.5	-0.3	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.2	1.5	-0.9	0.9	1.2	1.5
Medication: Cholesterol lowering	0.9	1.4	2.0	-0.3	1.3	-1.2	-1.3	-1.4
Depression (self-reported)	0.1	0.2	0.6	0.8	-0.3	-0.0	0.0	0.4
Medication: Lansoprazole	0.9	1.0	1.9	1.0	-1.0	0.7	0.9	1.4
Prospective memory result	0.5	0.7	1.2	1.1	-1.0	0.8	0.6	-0.0
Lung cancer (father)	0.3	0.3	1.1	-1.0	0.0	0.0	-0.2	-0.6
Illnesses of mother	0.7	0.9	1.2	1.1	-1.0	1.0	1.0	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	0.5	0.1	0.3	-0.0	0.3
Pulse wave Arterial Stiffness index	0.9	1.0	1.9	-0.0	0.9	-1.1	-1.0	-1.4
Impedance of arm (left)	0.1	0.3	0.6	0.5	-0.4	0.4	0.3	0.8
Arm fat mass (right)	1.4	5.9	7.1	-2.6	2.5	-1.9	-2.7	-2.4
Trunk predicted mass	0.2	0.9	1.8	-0.8	1.4	-0.8	-1.1	-0.4
Standing height	0.0	0.5	1.1	1.0	0.2	0.5	-0.1	1.0
Length of working week for main job	0.0	0.0	0.1	0.1	0.2	-0.2	-0.1	-0.0
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.5	-0.7	0.5	0.4	-0.1
Breastfed as a baby	0.1	0.1	0.3	0.5	-0.2	-0.0	0.0	-0.1
Tense / ‘highly strung’	4.5	7.4	10.1	2.2	-2.8	3.2	2.8	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.8	-0.3	0.1	0.0	-0.8
Hair/balding pattern: Pattern 4	0.5	1.3	3.4	0.1	1.0	-1.0	-1.1	-1.9
Birth weight of first child	0.2	0.3	1.2	0.1	-0.3	-0.2	0.6	1.1
Peak expiratory flow (PEF)	0.7	1.7	3.3	1.8	-0.9	1.3	0.8	1.4
Pulse wave reflection index	0.4	0.5	0.7	-0.5	0.7	-0.8	-0.6	-0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	0.2	-0.6	0.4	0.5	0.3
Loud music exposure frequency	0.8	0.9	1.3	0.2	-1.1	1.1	1.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.8	-0.8	0.6	-0.9	-0.3	0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.4	0.3	0.5	-0.6	-0.6	-0.6
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.0	0.4	-0.2	-0.2	0.0
Medication: Paracetamol	3.6	5.9	6.8	2.2	-2.6	2.4	2.6	2.4
Headache pain in last month	4.7	8.1	12.4	1.7	-2.9	2.6	3.1	3.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.7	0.2	-1.4	1.3	1.4	1.6
Glaucoma (self-reported)	0.5	0.6	1.9	0.5	0.5	-0.7	-0.4	-1.4
Gout (self-reported)	5.2	7.1	8.5	-2.4	2.7	-2.9	-2.7	-2.6
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.6	-0.2	-1.1	1.4	1.6	1.9
Medication: Amlodipine	3.4	4.8	6.2	-1.1	2.4	-2.3	-2.4	-2.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.4	-0.6	0.6	0.6	0.9
Birth weight	2.7	5.8	9.2	-1.2	2.2	-2.5	-2.6	-3.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	0.3	-0.3	0.5	0.4	0.7
High blood pressure (siblings)	0.1	0.1	0.3	-0.4	0.1	0.0	-0.2	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	0.6	-0.2	0.5	0.3	0.7
Body fat percentage	2.1	8.3	10.2	-3.0	2.8	-2.3	-3.2	-3.0
Leg fat percentage (right)	2.3	8.3	9.7	-3.1	2.7	-2.5	-3.1	-3.0
Arm fat-free mass (right)	0.3	1.7	2.7	-1.2	1.6	-1.0	-1.5	-1.1
Exposure to tobacco smoke outside home	0.9	1.2	3.1	1.8	-0.9	1.1	0.6	0.4
Comparative body size at age 10	0.4	1.0	1.9	-1.4	1.0	-0.9	-0.9	-0.6
Number of full brothers	0.7	0.9	2.2	-0.4	0.8	-0.7	-1.0	-1.5
Worry too long after embarrassment	0.0	0.1	0.3	0.5	-0.0	-0.2	-0.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.9	-0.3	0.9	-1.1	-1.4	-2.2
Wheeze or whistling in the chest in last year	0.8	1.4	3.2	-0.1	-1.2	1.0	1.2	1.8
Number of children fathered	0.5	0.6	0.8	0.9	-0.9	0.8	0.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.0	1.0	-0.3	0.5	0.6	0.7
Age at first live birth	0.1	0.2	0.6	-0.8	0.1	0.1	0.2	0.4
Pulse wave peak to peak time	0.4	0.5	1.2	-0.3	-0.5	0.8	0.6	1.1
Health satisfaction	0.1	0.2	0.9	1.0	-0.0	0.0	0.0	-0.1
Shortness of breath walking on level ground	0.0	0.0	0.1	0.3	-0.1	-0.0	-0.0	0.1
Qualifications: College or University degree	0.2	0.5	1.5	-1.2	0.7	-0.4	-0.0	0.6
Eye problems/disorders: None of the above	0.6	0.7	2.6	-1.6	0.7	-0.5	-0.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.7	-0.6	0.9	-0.5	-1.3	-1.0
Emphysema/chronic bronchitis	0.3	0.3	0.5	0.2	-0.7	0.7	0.7	0.5
Medication for pain relief, constipation, heartburn	1.2	2.1	3.1	-1.8	1.4	-1.2	-1.4	-1.5
Neck or shoulder pain in last month	3.5	5.0	6.4	1.5	-2.5	2.4	2.4	2.2
Medication: Blood pressure	0.5	0.9	1.3	-0.0	1.1	-1.0	-1.0	-1.2
Angina (self-reported)	0.3	0.3	0.9	0.3	-0.3	0.6	0.4	0.9
Migraine (self-reported)	7.5	9.3	10.2	2.7	-3.2	3.0	3.1	3.2
Medication: Ibuprofen	0.9	1.1	2.8	1.7	-0.7	0.6	0.9	1.0
Medication: Allopurinol	10.1	13.4	15.1	-3.3	3.6	-3.8	-3.6	-3.9
Medication: Omeprazole	0.7	0.9	2.2	-0.2	0.7	-0.7	-1.0	-1.5
Medication: Seretide 50 evohaler	0.0	0.1	0.1	0.2	0.1	-0.2	-0.4	-0.1
Mean time to correctly identify matches	0.7	1.4	4.0	1.1	0.6	-0.7	-1.0	-2.0
Heart disease (mother)	0.0	0.0	0.1	-0.0	0.0	-0.2	-0.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	-0.7	0.5	-0.8	-0.5	-0.4
Whole body fat mass	1.7	7.3	9.1	-2.9	2.7	-2.1	-3.0	-2.6
Leg fat mass (right)	1.9	7.4	8.7	-3.0	2.7	-2.2	-2.9	-2.8
Arm predicted mass (right)	0.3	1.6	2.4	-1.3	1.6	-1.0	-1.4	-0.9
Pulse rate, automated reading	0.8	2.6	4.6	2.1	-1.7	1.8	1.4	0.8
Alcohol intake frequency.	0.0	0.1	0.3	-0.0	-0.4	0.5	0.2	-0.1
Comparative height size at age 10	0.1	0.3	1.2	-0.1	0.5	-0.0	-0.2	1.1
Number of full sisters	2.3	2.7	6.0	-1.4	1.1	-1.4	-1.6	-2.4
Suffer from ‘nerves’	1.8	2.8	3.7	0.9	-1.7	1.9	1.8	1.9
Overall health rating	0.1	0.3	0.6	0.8	-0.6	0.6	0.3	-0.3
Chest pain or discomfort	4.1	5.9	7.8	2.4	-2.3	2.2	2.3	2.8
Had major operations	0.2	0.2	0.6	0.3	-0.4	0.2	0.4	0.8
Age at last live birth	0.2	0.3	0.6	0.1	-0.7	0.7	0.6	0.3
Family relationship satisfaction	3.8	4.7	5.8	-1.4	2.4	-2.4	-2.3	-2.1
Leg pain on walking	1.3	1.6	2.2	1.2	-1.5	1.2	1.3	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	1.0	-0.4	0.4	0.2	0.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.5	-0.2	-0.1	-0.1	0.3
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	2.8	-1.7	1.4	-1.4	-1.4	-1.0
Medication: Aspirin	0.0	0.0	0.0	0.0	0.1	0.0	-0.1	-0.2
Supplements: Vitamin C	7.3	8.6	11.4	2.0	-3.0	3.0	3.4	3.1
Knee pain experienced in last month	0.2	0.3	0.9	0.0	0.4	-0.3	-0.7	-0.9
Hypertension (Self-reported)	0.2	0.5	1.1	0.7	0.6	-0.5	-0.6	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	-0.2	0.4	-0.7	-0.7	-0.7
Illnesses of father: Heart disease	4.5	6.3	9.3	1.8	-2.4	2.7	2.4	3.0
Illnesses of siblings: Diabetes	0.7	0.9	1.1	0.9	-0.9	1.0	0.9	0.8
Smoking status: Previous	0.5	0.8	1.6	1.3	-1.0	1.0	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	2.6	-1.4	1.6	-1.4	-1.1	-0.8
Whole body fat-free mass	0.3	1.7	3.0	-1.1	1.7	-1.1	-1.6	-1.0
Leg fat-free mass (right)	0.7	3.6	5.2	-1.5	2.3	-1.6	-2.2	-1.8
Arm fat percentage (left)	2.1	8.2	9.7	-3.0	2.8	-2.3	-3.1	-3.0
Average weekly red wine intake	4.0	5.9	6.6	2.2	-2.6	2.4	2.4	2.5
Handedness (chirality/laterality): Left-handed	5.5	6.6	8.5	2.5	-2.9	2.8	2.4	2.2
Mood swings	0.1	0.2	0.3	0.1	-0.5	0.4	0.4	0.6
Loneliness, isolation	2.4	3.3	5.8	-2.4	1.7	-1.8	-1.7	-1.2
Long-standing illness, disability or infirmity	1.4	2.2	4.3	2.1	-1.6	1.3	1.3	0.9
Ever had bowel cancer screening	0.1	0.1	0.3	0.6	0.0	-0.0	0.0	0.1
Diabetes diagnosed by doctor	0.5	0.8	1.3	0.7	-0.8	1.1	0.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.5	-0.5	0.4	0.3	0.1
Friendships satisfaction	0.5	0.6	1.1	-1.0	0.8	-0.7	-0.8	-0.6
Qualifications: nursing, teaching	3.8	5.9	7.8	2.3	-2.3	2.3	2.4	2.8
Commuting to job workplace: Walk	0.6	0.7	2.0	-1.4	0.6	-0.7	-0.5	-0.5
Eye problems/disorders: Cataract	0.8	1.0	1.3	1.0	-1.2	1.1	1.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.0	-2.0	0.5	-0.8	-0.3	-0.8
Medication for cholesterol	0.3	0.5	1.1	1.1	-0.7	0.4	0.7	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	0.6	-0.2	0.2	0.5	0.9
Back pain experienced in last month	0.6	0.8	1.2	-0.5	0.8	-1.0	-1.0	-1.1
Mineral and other dietary supplements	0.6	0.8	1.9	-1.4	0.4	-0.4	-0.5	-1.1
Breast cancer (self-reported)	0.3	0.4	0.6	-0.0	0.6	-0.8	-0.7	-0.6
Asthma (self-reported)	0.1	0.1	0.3	-0.3	0.3	-0.6	-0.4	-0.0
Osteoporosis (self-reported)	0.7	0.9	1.2	-1.1	1.0	-1.1	-0.9	-0.5
Osteoarthritis (self-reported)	0.8	1.0	1.5	-1.2	0.8	-1.2	-0.9	-0.8
Medication: Aspirin	0.2	0.2	0.4	0.4	-0.6	0.6	0.4	0.3
Medication: Gliclazide	0.5	0.5	2.2	-1.5	0.5	-0.2	-0.5	-0.1
Illnesses of father: None of the above (group 1)	4.2	5.2	7.6	-1.0	2.5	-2.8	-2.2	-2.5
Smoking status: Current	0.4	0.7	1.2	1.1	-0.8	0.6	0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.9	0.2	0.6	-0.4	-0.5	-0.9
Whole body water mass	0.2	1.3	2.3	-0.9	1.5	-0.9	-1.3	-0.8
Leg predicted mass (right)	0.7	3.9	5.5	-1.5	2.4	-1.7	-2.3	-1.9
Arm fat mass (left)	1.6	6.6	8.0	-2.7	2.7	-2.0	-2.8	-2.5
Number of self-reported non-cancer illnesses	0.4	0.7	1.1	0.9	-1.1	0.7	0.9	0.7
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.7	0.2	-0.2	0.0	0.5
Miserableness	1.8	3.1	6.7	-2.6	1.5	-1.6	-1.4	-1.4
Guilty feelings	0.5	0.7	1.9	-1.4	0.7	-0.8	-0.8	-0.2
Wears glasses or contact lenses	0.2	0.3	0.4	0.0	0.5	-0.6	-0.5	-0.7
Ever taken oral contraceptive pill	0.4	0.5	1.2	-1.1	0.6	-0.7	-0.4	-0.3
Hearing aid user	1.8	2.0	2.5	-1.1	1.5	-1.6	-1.4	-1.5
Mother’s age at death	0.3	0.4	1.1	0.3	0.4	-0.5	-0.5	-1.1
Financial situation satisfaction	0.1	0.2	0.7	0.8	-0.3	0.1	-0.0	-0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.2	1.1	-0.9	0.7	0.7	0.6
Commuting to job workplace: Public transport	0.0	0.1	0.1	0.3	0.1	0.1	0.3	0.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.1	-0.7	1.1	-1.2	-1.0	-1.5
Medication: Blood pressure	0.1	0.2	0.4	-0.1	0.4	-0.3	-0.5	-0.7
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	0.6	-1.2	1.1	0.9	0.8
Supplements: Fish oil (including cod liver oil)	2.2	2.8	5.9	2.4	-1.3	1.3	1.3	1.8
High cholesterol (Self-reported)	0.2	0.4	1.9	1.4	-0.2	0.3	0.2	0.3
Medication: Bendroflumethiazide	0.5	0.8	1.5	1.2	-0.9	1.0	0.7	0.3
Medication: Paracetamol	3.6	5.6	6.8	2.1	-2.5	2.3	2.6	2.3
Medication: Lisinopril	2.1	2.7	6.4	2.5	-1.5	1.6	1.2	0.8
Medication: Atorvastatin	3.1	3.9	5.2	-1.2	2.2	-2.1	-2.3	-1.9
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.5	-0.1	0.2	-0.1	-0.4
Alcohol drinker status: Never	1.4	1.7	2.9	-1.0	1.2	-1.3	-1.1	-1.7
Ever smoked	0.6	1.1	3.4	1.8	-1.1	0.8	0.7	0.3
Basal metabolic rate	0.5	2.6	4.0	-1.5	2.0	-1.3	-1.9	-1.3
Leg fat percentage (left)	2.3	8.4	10.2	-3.0	2.7	-2.5	-3.1	-3.2
Arm fat-free mass (left)	0.2	1.1	1.7	-1.1	1.3	-0.7	-1.2	-0.7
Number of operations (self-reported)	0.3	0.4	0.9	0.1	0.6	-1.0	-0.7	-0.5
Average weekly beer plus cider intake	1.3	1.9	3.8	1.9	-1.6	1.4	1.0	-0.1
Irritability	0.0	0.1	0.1	0.4	0.0	-0.2	-0.3	-0.1
Risk taking	0.1	0.1	0.2	-0.5	0.2	-0.2	-0.2	-0.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.7	0.5	0.8	-0.8	-0.5	-0.2
Fractured/broken bones in last 5 years	4.5	5.8	8.9	-3.0	2.6	-2.4	-2.3	-1.5
Age started oral contraceptive pill	1.3	1.6	2.4	-0.3	1.3	-1.6	-1.4	-1.3
Diastolic blood pressure, automated reading	2.5	7.9	9.0	-2.8	3.0	-2.7	-2.8	-2.7
Ever depressed for a whole week	3.0	3.7	4.9	1.3	-1.9	2.0	2.1	2.2
Unable to work because of sickness or disability	0.1	0.2	0.5	0.3	0.0	-0.3	-0.4	-0.7
Commuting to job workplace: Cycle	0.4	0.4	0.8	-0.3	0.6	-0.8	-0.5	-0.9
Myopia	0.1	0.1	0.5	0.7	0.1	-0.0	-0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.9	-0.2	-0.8	0.7	1.1	1.4
Cholesterol lowering medication	0.2	0.2	0.5	-0.5	0.5	-0.4	-0.7	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.2	0.1	-0.0	0.0	-0.2	-0.5
Pain experienced in last month	1.4	2.3	2.9	-1.1	1.7	-1.5	-1.7	-1.5
Supplements: Calcium	0.3	0.4	0.8	-0.3	0.8	-0.9	-0.4	-0.1
Basal cell carcinoma (self-reported)	1.9	2.2	3.2	-0.9	1.5	-1.6	-1.6	-1.8
Heart attack/myocardial infarction (self-reported)	1.1	1.4	1.9	0.5	-1.4	1.3	1.2	1.4
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	-0.1	0.4	-0.3	-0.2	0.0
Heart disease (siblings)	0.4	0.5	1.0	0.3	-0.8	1.0	0.6	0.7
Alcohol drinker status: Previous	1.2	1.3	1.5	1.1	-1.1	1.2	1.1	1.1
Pack years of smoking	0.2	0.2	0.5	0.7	-0.4	0.4	0.4	0.2
Impedance of whole body	0.2	1.0	1.4	0.7	-1.2	0.9	1.0	1.1
Leg fat mass (left)	1.8	7.0	8.2	-2.8	2.6	-2.1	-2.9	-2.7
Arm predicted mass (left)	0.2	1.0	1.8	-0.9	1.3	-0.8	-1.2	-0.7