Hub : Genes

BRCA1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Muscularis 0.0560 0.0320 0.00740 0.005 NA 0.003 NA 0.002 1.6e-01 NA 1.9e-01 NA 2.4e-01
2 GTEx Liver 0.1150 0.0610 0.00880 0.056 NA 0.007 NA 0.032 1.1e-02 NA 2.0e-01 NA 4.5e-02
3 YFS Blood 0.0650 0.0165 0.00000 0.143 0.145 0.140 0.146 0.141 1.7e-44 4.2e-45 1.4e-43 2.1e-45 7.7e-44
4 TCGA Cervical Squamous Cell Carcinoma 0.0520 0.0370 0.00800 0.003 0.022 -0.001 NA 0.003 2.3e-01 2.7e-02 3.8e-01 NA 2.1e-01
5 TCGA Head and Neck Squamous Cell Carcinoma 0.0564 0.0398 0.00053 0.011 0.026 0.022 NA 0.022 1.9e-02 5.1e-04 1.6e-03 NA 1.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 1.3 1.1 -0.4 0.1 0.2 -0.4
Bipolar Disorder or Schizophrenia 0.4 1.0 1.6 0.8 -1.2 1.1 1.2 0.5
Depressed Affect (Nagel 2018) 0.1 0.1 0.6 -0.8 -0.1 0.1 -0.0 0.1
Depression (Nagel 2018) 0.3 0.4 1.4 1.2 -0.6 0.4 0.2 -0.3
Intelligence (Savage-Jansen 2018) 0.3 1.0 1.9 -0.2 1.2 -1.4 -1.2 -0.4
Neuroticism (Nagel 2018) 0.3 0.7 1.3 -0.1 -0.6 1.0 0.9 1.2
Schizophrenia (2018) 0.6 1.3 1.8 0.1 -1.3 1.3 1.3 1.0
Schizophrenia vs Biploar Disorder 1.4 1.8 3.2 0.7 -1.0 1.6 1.4 1.8
Worry (Nagel 2018) 1.8 3.8 6.3 0.5 -1.8 2.2 2.1 2.5
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 -0.3 -0.1 0.2 0.2 0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.7 -0.8 0.2 0.1 -0.3 -0.5
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 -0.6 0.1 0.0 -0.1 -0.3
Crohns Disease (2017) 1.4 3.0 6.5 -2.5 1.6 -1.8 -1.2 -1.2
Irritable Bowel Disease (IBD) 0.7 1.7 3.8 -1.9 1.4 -1.2 -0.9 -0.9
Ulcerative Colitis (UC) 0.1 0.2 0.6 -0.4 0.8 -0.4 -0.4 -0.3
Major Depression (MDD) 0.5 0.7 1.5 -0.0 -0.7 0.8 0.8 1.2
Reaction Time 0.3 0.6 2.1 1.4 -0.1 0.1 -0.2 -0.9
Verbal and Numeric Reasoning (VNR) 0.7 1.8 2.2 -1.0 1.5 -1.5 -1.5 -1.1
Breast Cancer 0.4 1.1 2.5 -0.2 1.2 -0.8 -0.8 -1.6
Ovarian Cancer 1.1 1.4 2.0 1.1 -1.1 1.4 1.1 1.2
Prostate Cancer 0.4 0.5 1.0 -1.0 0.8 -0.5 -0.5 0.5
Age at First Birth 0.0 0.0 0.1 0.1 -0.2 0.1 0.2 0.1
Bipolar Disorder (2011) 0.7 0.7 1.0 0.6 -0.8 0.8 1.0 0.9
Body Mass Index (BMI) (2010) 2.9 4.0 6.8 -2.6 2.0 -1.7 -1.9 -1.5
Coronary Artery Disease (CAD) 1.2 1.4 2.2 0.2 -1.5 1.2 1.3 1.3
Crohns Disease (2012) 1.1 1.7 3.2 -1.8 1.1 -1.2 -1.0 -1.3
Mean Putamen Volume 0.3 0.4 0.9 0.6 -0.5 0.9 0.6 -0.1
Fasting Glucose 1.2 1.5 2.5 1.1 -0.9 1.5 1.6 0.9
HbA1C 3.9 4.3 5.6 1.8 -2.0 2.4 2.4 1.9
HDL Cholesterol 1.7 2.8 7.1 -2.7 1.3 -1.6 -1.2 -1.1
LDL Cholesterol 0.3 0.4 0.6 -0.8 0.3 -0.8 -0.7 -0.4
Lupus 2.6 4.0 4.3 1.8 -1.9 2.1 2.1 2.1
Neuroticism (2016) 1.0 1.4 2.3 1.1 -1.1 1.1 1.0 1.5
Primary Biliary Cirrhosis 0.2 0.2 0.5 0.0 -0.6 0.5 0.4 0.7
Rheumatoid Arthritis 0.3 0.4 0.6 0.4 -0.6 0.7 0.6 0.7
Schizophrenia (2014) 2.5 5.5 6.8 1.5 -2.5 2.6 2.6 2.4
Triglycerides 2.9 4.8 12.0 3.5 -1.6 2.2 1.8 1.1
Type 2 Diabetes (T2D) (2012) 1.5 1.8 2.8 0.8 -1.2 1.7 1.6 1.1
Ulcerative Colitis 0.1 0.2 0.8 -0.9 0.1 -0.1 -0.1 -0.5
Blood Eosinophil Count 2.0 15.4 20.2 -4.5 4.5 -3.6 -4.0 -2.7
Blood Platelet Count 0.0 0.2 0.4 -0.7 -0.3 0.1 -0.4 -0.5
Blood Red Count 0.0 0.3 0.7 -0.1 -0.6 0.9 0.7 0.1
Blood White Count 4.6 33.8 39.9 -5.7 6.1 -5.3 -6.3 -5.6
Heel T-Score 2.8 22.0 31.4 4.7 -5.6 5.1 4.3 3.5
BMI 1.9 11.1 19.0 -4.4 3.2 -2.5 -3.2 -3.0
Height 0.0 0.5 1.2 0.1 1.1 0.0 -0.9 0.6
Waist Hip Ratio (WHR) 0.2 1.1 2.8 1.7 -1.1 0.5 0.2 -1.1
Systolic Blood Pressure 1.0 4.8 7.8 1.4 -2.0 2.2 2.2 2.8
Smoking Status 1.6 3.7 4.3 1.9 -2.0 1.9 1.8 2.1
Allergy or Eczema 0.0 0.1 0.3 0.1 0.1 -0.4 -0.3 -0.6
Cardiovascular Disease 0.7 2.4 3.6 1.9 -1.4 1.8 1.3 1.2
Hypothyroidism (self reported) 0.8 1.9 3.6 0.4 -1.1 1.3 1.6 1.9
Respiratory disease 0.2 0.4 0.7 -0.8 0.6 -0.8 -0.6 -0.4
Type 2 Diabetes (T2D) (2018) 0.5 0.8 1.4 0.5 -0.8 1.2 0.8 1.1
Lung FEV1/FVC ratio 0.7 3.7 5.2 -0.4 2.2 -1.8 -2.2 -2.3
Lung FVC 0.1 0.7 1.1 1.1 -0.7 0.7 0.9 0.8
Neuroticism 0.3 0.8 1.1 -0.1 -0.9 1.0 1.0 1.1
Chronotype (morning person) 0.3 0.6 2.5 1.6 -0.3 0.4 0.4 -0.2
Hair Pigment 0.0 0.1 0.2 0.5 -0.5 0.5 0.2 0.0
Tanning 0.2 2.5 3.2 1.7 -1.5 1.2 1.8 1.7
Hand grip strength (left) 4.6 12.2 14.9 2.6 -3.5 3.9 3.7 3.7
Number of treatments/medications taken 0.8 1.4 1.7 1.2 -1.3 0.9 1.3 1.2
Average weekly spirits intake 0.7 0.9 2.3 1.5 -0.7 0.9 0.8 0.6
Sensitivity / hurt feelings 0.6 1.1 1.5 0.3 -1.2 1.2 1.2 1.0
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 0.6 -0.0 -0.3 -0.1 -0.2
Hearing difficulty/problems: Yes 0.5 0.7 1.7 -0.3 0.5 -0.9 -0.8 -1.3
Relative age of first facial hair 0.5 1.1 1.7 1.1 -1.3 1.3 0.9 0.2
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.9 1.4 -0.9 0.8 0.8 0.7
Ever used hormone-replacement therapy (HRT) 6.2 7.9 8.9 -2.5 2.9 -2.7 -3.0 -3.0
Ever had hysterectomy (womb removed) 1.5 1.7 2.2 -1.3 1.5 -1.4 -1.4 -0.8
Systolic blood pressure, automated reading 0.0 0.1 0.2 -0.3 0.1 -0.1 -0.1 0.4
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.9 1.4 -0.8 0.9 0.8 1.0
Angina 0.2 0.3 0.6 0.3 -0.3 0.6 0.4 0.8
Medication for hormone replacement therapy 0.2 0.2 1.0 -1.0 0.2 0.0 0.0 -0.1
Vitamin and mineral supplements 4.0 5.4 7.8 -1.3 2.3 -2.3 -2.6 -2.8
Supplements: Zinc 5.2 5.7 6.5 2.1 -2.5 2.4 2.5 2.4
Medication: Co-codamol 0.0 0.0 0.1 -0.2 0.1 0.2 -0.3 0.0
Medication: Metformin 0.6 0.9 2.0 0.0 -0.9 1.4 0.7 1.1
Diabetes (father) 0.3 0.3 1.0 0.1 -0.3 0.5 0.5 1.0
Diabetes (mother) 0.1 0.2 0.3 -0.2 0.5 -0.5 -0.5 -0.2
Severe depression (siblings) 5.8 6.5 10.0 3.2 -2.5 2.4 2.6 2.0
Pack years adult smoking proportion 0.3 0.4 0.7 0.8 -0.6 0.7 0.7 0.5
Impedance of leg (right) 1.0 5.0 7.6 1.4 -2.5 2.1 2.3 2.8
Leg fat-free mass (left) 0.7 3.9 5.6 -1.6 2.4 -1.6 -2.3 -1.8
Trunk fat percentage 1.9 7.8 9.9 -2.9 2.7 -2.2 -3.1 -2.9
Hand grip strength (right) 6.3 17.2 21.9 2.8 -4.2 4.5 4.4 4.7
Townsend deprivation index at recruitment 0.7 1.1 2.4 -0.8 0.8 -1.0 -0.7 -1.6
Current tobacco smoking 0.2 0.3 0.8 0.9 -0.4 0.3 0.4 0.4
Average weekly fortified wine intake 6.1 7.1 10.7 3.3 -2.8 2.7 2.5 1.8
Maternal smoking around birth 0.0 0.0 0.1 0.1 -0.1 0.3 0.2 -0.1
Fed-up feelings 0.1 0.2 0.4 0.0 0.2 -0.4 -0.7 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 3.6 -0.6 1.1 -1.1 -1.4 -1.9
Relative age voice broke 2.8 4.3 5.7 2.1 -2.4 2.2 1.9 1.6
Taking other prescription medications 0.3 0.5 0.8 0.1 -0.9 0.7 0.8 0.7
Age when periods started (menarche) 0.6 1.4 2.3 0.6 -1.1 1.4 1.5 1.2
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.5 -0.0 0.2 -0.4 -0.4 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.7 1.3 -1.1 1.0 0.4 -0.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.5 0.4 -0.3 0.4 0.3 1.2
Qualifications: CSEs or equivalent 2.3 3.0 3.9 1.1 -2.0 1.9 1.8 1.8
Serious illness, injury or assault to yourself 0.6 0.7 1.0 -0.7 0.8 -0.7 -0.8 -1.0
High blood pressure 0.2 0.5 1.3 0.4 0.7 -0.6 -0.8 -1.1
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.1 0.1 -0.3 -0.0 0.1 -0.1
Multivitamins +/- minerals 0.2 0.3 0.8 0.1 -0.4 0.3 0.6 0.9
Stomach or abdominal pain in last month 0.2 0.2 0.6 0.8 -0.4 0.3 0.2 -0.1
Supplements: Glucosamine 1.5 1.9 2.3 -1.0 1.5 -1.5 -1.5 -1.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.8 0.1 -0.5 0.6 0.6 0.9
Medication: Atenolol 0.2 0.2 0.8 -0.4 0.2 0.1 0.2 0.9
Medication: Levothyroxine sodium 0.3 0.4 1.3 -0.7 -0.1 0.3 0.4 1.1
Sitting height 1.0 6.8 9.6 -2.3 3.1 -2.6 -3.0 -1.9
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 -0.3 -0.0 -0.0 0.1 0.2
High blood pressure (mother) 0.5 0.6 1.0 -0.5 0.7 -1.0 -0.8 -1.0
Body mass index (BMI) 1.6 6.9 8.2 -2.9 2.6 -2.1 -2.7 -2.8
Impedance of leg (left) 1.0 5.0 6.5 1.5 -2.5 2.1 2.4 2.5
Leg predicted mass (left) 0.7 3.9 5.6 -1.7 2.4 -1.6 -2.3 -1.8
Trunk fat mass 1.8 7.8 10.3 -2.8 2.9 -2.2 -3.2 -2.8
Waist circumference 2.0 7.3 10.5 -2.2 2.6 -2.3 -3.0 -3.2
Number of incorrect matches in round 0.9 1.5 1.8 0.4 -1.3 1.3 1.4 1.3
Past tobacco smoking 0.6 1.1 3.0 -1.7 1.0 -0.9 -0.6 -0.1
Alcohol usually taken with meals 0.4 0.6 1.9 -0.9 0.1 0.2 0.5 1.4
Nervous feelings 0.1 0.2 0.3 -0.5 0.5 -0.3 -0.5 0.3
Frequency of tenseness / restlessness in last 2 weeks 2.2 3.4 3.7 1.8 -1.9 1.8 1.8 1.9
Hearing difficulty/problems with background noise 1.1 1.8 4.2 -0.5 1.0 -1.4 -1.3 -2.0
Hair/balding pattern: Pattern 2 0.5 0.6 1.0 1.0 -0.8 0.8 0.8 0.4
Had menopause 12.2 15.2 18.4 -3.5 4.3 -4.1 -4.2 -3.3
Had other major operations 0.1 0.1 0.5 0.7 -0.3 0.2 0.0 -0.2
Forced vital capacity (FVC) 0.3 1.3 2.2 1.2 -0.9 1.2 0.8 1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 2.6 1.6 -1.5 1.3 0.8 0.3
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.0 0.1 -0.1 0.1 0.2 0.1
Qualifications: None of the above 0.5 1.1 2.3 -0.7 0.8 -0.9 -1.1 -1.5
Financial difficulties in last 2 years 0.4 0.5 0.6 -0.6 0.7 -0.7 -0.7 -0.8
Mouth/teeth dental problems 0.1 0.2 0.6 0.5 -0.1 0.0 0.4 0.8
Heart attack 0.8 1.1 1.5 0.4 -1.2 1.2 1.1 1.1
Allergy 0.0 0.1 0.2 -0.3 0.3 0.1 0.0 0.4
Pain all over the body in last month 0.1 0.2 0.5 -0.7 0.3 -0.3 -0.2 0.3
Diabetes (self-reported) 0.2 0.3 0.6 0.2 -0.5 0.7 0.4 0.8
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 2.2 -1.3 1.3 -1.5 -1.0 -0.8
Medication: Ramipril 3.3 4.2 5.2 -1.8 2.2 -2.0 -2.3 -2.0
Medication: Simvastatin 0.1 0.1 0.2 0.4 0.2 -0.1 -0.3 -0.3
Fluid intelligence score 0.0 0.1 0.1 -0.3 0.3 -0.3 -0.1 0.3
Illnesses of siblings 0.2 0.3 0.8 0.5 -0.3 0.1 0.6 0.9
Neuroticism score 0.1 0.2 0.5 -0.7 -0.1 0.1 0.2 0.6
Weight 1.2 6.1 7.6 -2.4 2.7 -2.0 -2.8 -2.4
Impedance of arm (right) 0.2 1.1 1.7 1.0 -1.0 1.0 0.9 1.3
Arm fat percentage (right) 1.6 6.5 8.0 -2.8 2.5 -2.0 -2.8 -2.6
Trunk fat-free mass 0.1 0.9 1.8 -0.8 1.3 -0.8 -1.1 -0.4
Hip circumference 1.3 5.4 7.0 -2.6 2.6 -2.0 -2.5 -1.8
Time employed in main current job 0.5 0.6 1.0 0.2 0.9 -1.0 -0.9 -0.6
Alcohol intake versus 10 years previously 0.4 0.6 0.9 0.6 -0.9 0.9 0.7 0.7
Father’s age at death 0.1 0.2 0.4 0.7 0.2 -0.1 -0.1 0.5
Worrier / anxious feelings 2.4 4.6 6.3 1.6 -2.2 2.2 2.2 2.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 1.7 1.3 -1.3 0.7 1.1 0.7
Falls in the last year 1.8 2.4 5.4 1.0 -1.3 1.4 1.4 2.3
Hair/balding pattern: Pattern 3 0.5 0.8 1.3 0.7 0.8 -0.8 -1.1 -0.9
Number of live births 0.2 0.3 0.7 -0.5 0.2 -0.4 -0.5 -0.8
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.0 1.3 -0.9 1.3 0.9 1.4
Pulse rate 0.5 0.8 1.4 1.2 -1.0 0.9 0.8 0.5
Happiness 2.0 2.4 3.5 -0.6 1.6 -1.7 -1.7 -1.9
Noisy workplace 0.2 0.2 0.9 -0.2 -0.1 -0.1 -0.2 -0.9
Qualifications: A levels/AS levels or equivalent 2.3 5.1 7.2 -2.7 2.6 -2.5 -2.0 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.0 1.0 -0.1 -0.0 -0.1 0.0
Mouth/teeth dental problems: Dentures 0.2 0.3 0.5 0.7 -0.5 0.7 0.2 -0.1
Asthma 0.0 0.1 0.2 -0.0 0.2 -0.5 -0.3 -0.1
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 2.2 1.5 -0.9 0.9 1.2 1.5
Medication: Cholesterol lowering 0.9 1.4 2.0 -0.3 1.3 -1.2 -1.3 -1.4
Depression (self-reported) 0.1 0.2 0.6 0.8 -0.3 -0.0 0.0 0.4
Medication: Lansoprazole 0.9 1.0 1.9 1.0 -1.0 0.7 0.9 1.4
Prospective memory result 0.5 0.7 1.2 1.1 -1.0 0.8 0.6 -0.0
Lung cancer (father) 0.3 0.3 1.1 -1.0 0.0 0.0 -0.2 -0.6
Illnesses of mother 0.7 0.9 1.2 1.1 -1.0 1.0 1.0 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 0.5 0.1 0.3 -0.0 0.3
Pulse wave Arterial Stiffness index 0.9 1.0 1.9 -0.0 0.9 -1.1 -1.0 -1.4
Impedance of arm (left) 0.1 0.3 0.6 0.5 -0.4 0.4 0.3 0.8
Arm fat mass (right) 1.4 5.9 7.1 -2.6 2.5 -1.9 -2.7 -2.4
Trunk predicted mass 0.2 0.9 1.8 -0.8 1.4 -0.8 -1.1 -0.4
Standing height 0.0 0.5 1.1 1.0 0.2 0.5 -0.1 1.0
Length of working week for main job 0.0 0.0 0.1 0.1 0.2 -0.2 -0.1 -0.0
Exposure to tobacco smoke at home 0.2 0.2 0.5 0.5 -0.7 0.5 0.4 -0.1
Breastfed as a baby 0.1 0.1 0.3 0.5 -0.2 -0.0 0.0 -0.1
Tense / ‘highly strung’ 4.5 7.4 10.1 2.2 -2.8 3.2 2.8 2.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.7 0.8 -0.3 0.1 0.0 -0.8
Hair/balding pattern: Pattern 4 0.5 1.3 3.4 0.1 1.0 -1.0 -1.1 -1.9
Birth weight of first child 0.2 0.3 1.2 0.1 -0.3 -0.2 0.6 1.1
Peak expiratory flow (PEF) 0.7 1.7 3.3 1.8 -0.9 1.3 0.8 1.4
Pulse wave reflection index 0.4 0.5 0.7 -0.5 0.7 -0.8 -0.6 -0.8
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.3 0.2 -0.6 0.4 0.5 0.3
Loud music exposure frequency 0.8 0.9 1.3 0.2 -1.1 1.1 1.2 0.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.8 -0.8 0.6 -0.9 -0.3 0.2
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.4 0.3 0.5 -0.6 -0.6 -0.6
Blood clot in the leg (DVT) 0.0 0.0 0.1 0.0 0.4 -0.2 -0.2 0.0
Medication: Paracetamol 3.6 5.9 6.8 2.2 -2.6 2.4 2.6 2.4
Headache pain in last month 4.7 8.1 12.4 1.7 -2.9 2.6 3.1 3.5
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 2.7 0.2 -1.4 1.3 1.4 1.6
Glaucoma (self-reported) 0.5 0.6 1.9 0.5 0.5 -0.7 -0.4 -1.4
Gout (self-reported) 5.2 7.1 8.5 -2.4 2.7 -2.9 -2.7 -2.6
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.6 -0.2 -1.1 1.4 1.6 1.9
Medication: Amlodipine 3.4 4.8 6.2 -1.1 2.4 -2.3 -2.4 -2.5
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.8 0.4 -0.6 0.6 0.6 0.9
Birth weight 2.7 5.8 9.2 -1.2 2.2 -2.5 -2.6 -3.0
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.5 0.3 -0.3 0.5 0.4 0.7
High blood pressure (siblings) 0.1 0.1 0.3 -0.4 0.1 0.0 -0.2 -0.6
Forced vital capacity (FVC), Best measure 0.1 0.2 0.5 0.6 -0.2 0.5 0.3 0.7
Body fat percentage 2.1 8.3 10.2 -3.0 2.8 -2.3 -3.2 -3.0
Leg fat percentage (right) 2.3 8.3 9.7 -3.1 2.7 -2.5 -3.1 -3.0
Arm fat-free mass (right) 0.3 1.7 2.7 -1.2 1.6 -1.0 -1.5 -1.1
Exposure to tobacco smoke outside home 0.9 1.2 3.1 1.8 -0.9 1.1 0.6 0.4
Comparative body size at age 10 0.4 1.0 1.9 -1.4 1.0 -0.9 -0.9 -0.6
Number of full brothers 0.7 0.9 2.2 -0.4 0.8 -0.7 -1.0 -1.5
Worry too long after embarrassment 0.0 0.1 0.3 0.5 -0.0 -0.2 -0.1 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 4.9 -0.3 0.9 -1.1 -1.4 -2.2
Wheeze or whistling in the chest in last year 0.8 1.4 3.2 -0.1 -1.2 1.0 1.2 1.8
Number of children fathered 0.5 0.6 0.8 0.9 -0.9 0.8 0.8 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.0 1.0 -0.3 0.5 0.6 0.7
Age at first live birth 0.1 0.2 0.6 -0.8 0.1 0.1 0.2 0.4
Pulse wave peak to peak time 0.4 0.5 1.2 -0.3 -0.5 0.8 0.6 1.1
Health satisfaction 0.1 0.2 0.9 1.0 -0.0 0.0 0.0 -0.1
Shortness of breath walking on level ground 0.0 0.0 0.1 0.3 -0.1 -0.0 -0.0 0.1
Qualifications: College or University degree 0.2 0.5 1.5 -1.2 0.7 -0.4 -0.0 0.6
Eye problems/disorders: None of the above 0.6 0.7 2.6 -1.6 0.7 -0.5 -0.5 -0.1
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.7 -0.6 0.9 -0.5 -1.3 -1.0
Emphysema/chronic bronchitis 0.3 0.3 0.5 0.2 -0.7 0.7 0.7 0.5
Medication for pain relief, constipation, heartburn 1.2 2.1 3.1 -1.8 1.4 -1.2 -1.4 -1.5
Neck or shoulder pain in last month 3.5 5.0 6.4 1.5 -2.5 2.4 2.4 2.2
Medication: Blood pressure 0.5 0.9 1.3 -0.0 1.1 -1.0 -1.0 -1.2
Angina (self-reported) 0.3 0.3 0.9 0.3 -0.3 0.6 0.4 0.9
Migraine (self-reported) 7.5 9.3 10.2 2.7 -3.2 3.0 3.1 3.2
Medication: Ibuprofen 0.9 1.1 2.8 1.7 -0.7 0.6 0.9 1.0
Medication: Allopurinol 10.1 13.4 15.1 -3.3 3.6 -3.8 -3.6 -3.9
Medication: Omeprazole 0.7 0.9 2.2 -0.2 0.7 -0.7 -1.0 -1.5
Medication: Seretide 50 evohaler 0.0 0.1 0.1 0.2 0.1 -0.2 -0.4 -0.1
Mean time to correctly identify matches 0.7 1.4 4.0 1.1 0.6 -0.7 -1.0 -2.0
Heart disease (mother) 0.0 0.0 0.1 -0.0 0.0 -0.2 -0.3 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.7 -0.7 0.5 -0.8 -0.5 -0.4
Whole body fat mass 1.7 7.3 9.1 -2.9 2.7 -2.1 -3.0 -2.6
Leg fat mass (right) 1.9 7.4 8.7 -3.0 2.7 -2.2 -2.9 -2.8
Arm predicted mass (right) 0.3 1.6 2.4 -1.3 1.6 -1.0 -1.4 -0.9
Pulse rate, automated reading 0.8 2.6 4.6 2.1 -1.7 1.8 1.4 0.8
Alcohol intake frequency. 0.0 0.1 0.3 -0.0 -0.4 0.5 0.2 -0.1
Comparative height size at age 10 0.1 0.3 1.2 -0.1 0.5 -0.0 -0.2 1.1
Number of full sisters 2.3 2.7 6.0 -1.4 1.1 -1.4 -1.6 -2.4
Suffer from ‘nerves’ 1.8 2.8 3.7 0.9 -1.7 1.9 1.8 1.9
Overall health rating 0.1 0.3 0.6 0.8 -0.6 0.6 0.3 -0.3
Chest pain or discomfort 4.1 5.9 7.8 2.4 -2.3 2.2 2.3 2.8
Had major operations 0.2 0.2 0.6 0.3 -0.4 0.2 0.4 0.8
Age at last live birth 0.2 0.3 0.6 0.1 -0.7 0.7 0.6 0.3
Family relationship satisfaction 3.8 4.7 5.8 -1.4 2.4 -2.4 -2.3 -2.1
Leg pain on walking 1.3 1.6 2.2 1.2 -1.5 1.2 1.3 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.0 1.0 -0.4 0.4 0.2 0.1
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 0.5 -0.2 -0.1 -0.1 0.3
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 2.8 -1.7 1.4 -1.4 -1.4 -1.0
Medication: Aspirin 0.0 0.0 0.0 0.0 0.1 0.0 -0.1 -0.2
Supplements: Vitamin C 7.3 8.6 11.4 2.0 -3.0 3.0 3.4 3.1
Knee pain experienced in last month 0.2 0.3 0.9 0.0 0.4 -0.3 -0.7 -0.9
Hypertension (Self-reported) 0.2 0.5 1.1 0.7 0.6 -0.5 -0.6 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.6 -0.2 0.4 -0.7 -0.7 -0.7
Illnesses of father: Heart disease 4.5 6.3 9.3 1.8 -2.4 2.7 2.4 3.0
Illnesses of siblings: Diabetes 0.7 0.9 1.1 0.9 -0.9 1.0 0.9 0.8
Smoking status: Previous 0.5 0.8 1.6 1.3 -1.0 1.0 0.6 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 2.6 -1.4 1.6 -1.4 -1.1 -0.8
Whole body fat-free mass 0.3 1.7 3.0 -1.1 1.7 -1.1 -1.6 -1.0
Leg fat-free mass (right) 0.7 3.6 5.2 -1.5 2.3 -1.6 -2.2 -1.8
Arm fat percentage (left) 2.1 8.2 9.7 -3.0 2.8 -2.3 -3.1 -3.0
Average weekly red wine intake 4.0 5.9 6.6 2.2 -2.6 2.4 2.4 2.5
Handedness (chirality/laterality): Left-handed 5.5 6.6 8.5 2.5 -2.9 2.8 2.4 2.2
Mood swings 0.1 0.2 0.3 0.1 -0.5 0.4 0.4 0.6
Loneliness, isolation 2.4 3.3 5.8 -2.4 1.7 -1.8 -1.7 -1.2
Long-standing illness, disability or infirmity 1.4 2.2 4.3 2.1 -1.6 1.3 1.3 0.9
Ever had bowel cancer screening 0.1 0.1 0.3 0.6 0.0 -0.0 0.0 0.1
Diabetes diagnosed by doctor 0.5 0.8 1.3 0.7 -0.8 1.1 0.7 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 -0.5 -0.5 0.4 0.3 0.1
Friendships satisfaction 0.5 0.6 1.1 -1.0 0.8 -0.7 -0.8 -0.6
Qualifications: nursing, teaching 3.8 5.9 7.8 2.3 -2.3 2.3 2.4 2.8
Commuting to job workplace: Walk 0.6 0.7 2.0 -1.4 0.6 -0.7 -0.5 -0.5
Eye problems/disorders: Cataract 0.8 1.0 1.3 1.0 -1.2 1.1 1.1 0.6
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 4.0 -2.0 0.5 -0.8 -0.3 -0.8
Medication for cholesterol 0.3 0.5 1.1 1.1 -0.7 0.4 0.7 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.8 0.6 -0.2 0.2 0.5 0.9
Back pain experienced in last month 0.6 0.8 1.2 -0.5 0.8 -1.0 -1.0 -1.1
Mineral and other dietary supplements 0.6 0.8 1.9 -1.4 0.4 -0.4 -0.5 -1.1
Breast cancer (self-reported) 0.3 0.4 0.6 -0.0 0.6 -0.8 -0.7 -0.6
Asthma (self-reported) 0.1 0.1 0.3 -0.3 0.3 -0.6 -0.4 -0.0
Osteoporosis (self-reported) 0.7 0.9 1.2 -1.1 1.0 -1.1 -0.9 -0.5
Osteoarthritis (self-reported) 0.8 1.0 1.5 -1.2 0.8 -1.2 -0.9 -0.8
Medication: Aspirin 0.2 0.2 0.4 0.4 -0.6 0.6 0.4 0.3
Medication: Gliclazide 0.5 0.5 2.2 -1.5 0.5 -0.2 -0.5 -0.1
Illnesses of father: None of the above (group 1) 4.2 5.2 7.6 -1.0 2.5 -2.8 -2.2 -2.5
Smoking status: Current 0.4 0.7 1.2 1.1 -0.8 0.6 0.7 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.9 0.2 0.6 -0.4 -0.5 -0.9
Whole body water mass 0.2 1.3 2.3 -0.9 1.5 -0.9 -1.3 -0.8
Leg predicted mass (right) 0.7 3.9 5.5 -1.5 2.4 -1.7 -2.3 -1.9
Arm fat mass (left) 1.6 6.6 8.0 -2.7 2.7 -2.0 -2.8 -2.5
Number of self-reported non-cancer illnesses 0.4 0.7 1.1 0.9 -1.1 0.7 0.9 0.7
Average weekly champagne plus white wine intake 0.1 0.2 0.5 -0.7 0.2 -0.2 0.0 0.5
Miserableness 1.8 3.1 6.7 -2.6 1.5 -1.6 -1.4 -1.4
Guilty feelings 0.5 0.7 1.9 -1.4 0.7 -0.8 -0.8 -0.2
Wears glasses or contact lenses 0.2 0.3 0.4 0.0 0.5 -0.6 -0.5 -0.7
Ever taken oral contraceptive pill 0.4 0.5 1.2 -1.1 0.6 -0.7 -0.4 -0.3
Hearing aid user 1.8 2.0 2.5 -1.1 1.5 -1.6 -1.4 -1.5
Mother’s age at death 0.3 0.4 1.1 0.3 0.4 -0.5 -0.5 -1.1
Financial situation satisfaction 0.1 0.2 0.7 0.8 -0.3 0.1 -0.0 -0.3
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.2 1.1 -0.9 0.7 0.7 0.6
Commuting to job workplace: Public transport 0.0 0.1 0.1 0.3 0.1 0.1 0.3 0.3
Eye problems/disorders: Glaucoma 1.0 1.2 2.1 -0.7 1.1 -1.2 -1.0 -1.5
Medication: Blood pressure 0.1 0.2 0.4 -0.1 0.4 -0.3 -0.5 -0.7
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.4 0.6 -1.2 1.1 0.9 0.8
Supplements: Fish oil (including cod liver oil) 2.2 2.8 5.9 2.4 -1.3 1.3 1.3 1.8
High cholesterol (Self-reported) 0.2 0.4 1.9 1.4 -0.2 0.3 0.2 0.3
Medication: Bendroflumethiazide 0.5 0.8 1.5 1.2 -0.9 1.0 0.7 0.3
Medication: Paracetamol 3.6 5.6 6.8 2.1 -2.5 2.3 2.6 2.3
Medication: Lisinopril 2.1 2.7 6.4 2.5 -1.5 1.6 1.2 0.8
Medication: Atorvastatin 3.1 3.9 5.2 -1.2 2.2 -2.1 -2.3 -1.9
Illnesses of father: High blood pressure 0.1 0.1 0.3 -0.5 -0.1 0.2 -0.1 -0.4
Alcohol drinker status: Never 1.4 1.7 2.9 -1.0 1.2 -1.3 -1.1 -1.7
Ever smoked 0.6 1.1 3.4 1.8 -1.1 0.8 0.7 0.3
Basal metabolic rate 0.5 2.6 4.0 -1.5 2.0 -1.3 -1.9 -1.3
Leg fat percentage (left) 2.3 8.4 10.2 -3.0 2.7 -2.5 -3.1 -3.2
Arm fat-free mass (left) 0.2 1.1 1.7 -1.1 1.3 -0.7 -1.2 -0.7
Number of operations (self-reported) 0.3 0.4 0.9 0.1 0.6 -1.0 -0.7 -0.5
Average weekly beer plus cider intake 1.3 1.9 3.8 1.9 -1.6 1.4 1.0 -0.1
Irritability 0.0 0.1 0.1 0.4 0.0 -0.2 -0.3 -0.1
Risk taking 0.1 0.1 0.2 -0.5 0.2 -0.2 -0.2 -0.4
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.7 0.5 0.8 -0.8 -0.5 -0.2
Fractured/broken bones in last 5 years 4.5 5.8 8.9 -3.0 2.6 -2.4 -2.3 -1.5
Age started oral contraceptive pill 1.3 1.6 2.4 -0.3 1.3 -1.6 -1.4 -1.3
Diastolic blood pressure, automated reading 2.5 7.9 9.0 -2.8 3.0 -2.7 -2.8 -2.7
Ever depressed for a whole week 3.0 3.7 4.9 1.3 -1.9 2.0 2.1 2.2
Unable to work because of sickness or disability 0.1 0.2 0.5 0.3 0.0 -0.3 -0.4 -0.7
Commuting to job workplace: Cycle 0.4 0.4 0.8 -0.3 0.6 -0.8 -0.5 -0.9
Myopia 0.1 0.1 0.5 0.7 0.1 -0.0 -0.1 -0.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.9 -0.2 -0.8 0.7 1.1 1.4
Cholesterol lowering medication 0.2 0.2 0.5 -0.5 0.5 -0.4 -0.7 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.0 0.1 0.2 0.1 -0.0 0.0 -0.2 -0.5
Pain experienced in last month 1.4 2.3 2.9 -1.1 1.7 -1.5 -1.7 -1.5
Supplements: Calcium 0.3 0.4 0.8 -0.3 0.8 -0.9 -0.4 -0.1
Basal cell carcinoma (self-reported) 1.9 2.2 3.2 -0.9 1.5 -1.6 -1.6 -1.8
Heart attack/myocardial infarction (self-reported) 1.1 1.4 1.9 0.5 -1.4 1.3 1.2 1.4
Deep venous thrombosis (DVT) (self-reported) 0.0 0.1 0.1 -0.1 0.4 -0.3 -0.2 0.0
Heart disease (siblings) 0.4 0.5 1.0 0.3 -0.8 1.0 0.6 0.7
Alcohol drinker status: Previous 1.2 1.3 1.5 1.1 -1.1 1.2 1.1 1.1
Pack years of smoking 0.2 0.2 0.5 0.7 -0.4 0.4 0.4 0.2
Impedance of whole body 0.2 1.0 1.4 0.7 -1.2 0.9 1.0 1.1
Leg fat mass (left) 1.8 7.0 8.2 -2.8 2.6 -2.1 -2.9 -2.7
Arm predicted mass (left) 0.2 1.0 1.8 -0.9 1.3 -0.8 -1.2 -0.7