TWAS hub - BRMS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1100	0.0420	0.00270	0.030	0.014	0.032	0.030	0.016	0.00012	0.0063	8.7e-05	0.00012	0.0044
2	GTEx	Thyroid	0.0540	0.0290	0.00990	0.017	NA	0.009	NA	0.014	0.01800	NA	6.6e-02	NA	0.0260
3	YFS	Blood	0.0125	0.0059	0.00083	0.001	0.005	0.000	0.004	0.001	0.11000	0.0090	2.2e-01	0.01100	0.1300

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2011)	13.2	12.8	21.0	-0.5	4.6	4.1
Impedance of leg (right)	6.5	31.7	58.9	-1.2	-5.9	-7.7
Average weekly red wine intake	6.5	9.6	17.1	1.7	4.1	3.0
Medication: Allopurinol	6.2	8.2	19.4	-1.0	-2.0	-4.4
Chronotype (morning person)	6.1	14.1	21.4	-2.5	-3.8	-4.6
Bipolar Disorder or Schizophrenia	5.9	14.4	24.6	0.5	4.3	5.0
Commuting to job workplace: Cycle	5.8	7.1	14.4	1.1	3.8	2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	5.7	7.4	11.0	-2.1	3.3	2.6
Impedance of leg (left)	5.4	26.1	50.0	-1.3	-5.1	-7.1
Medication: Omeprazole (e.g. Zanprol)	5.4	6.6	8.7	2.0	2.9	2.6
Qualifications: None of the above	5.3	11.5	23.9	2.3	-4.9	-2.3
Hearing difficulty/problems: Yes	5.2	8.0	15.6	-0.5	2.8	4.0
Qualifications: College or University degree	5.1	16.0	35.6	-1.4	6.0	3.3
Bipolar Disorder (2018)	4.8	7.6	14.6	0.1	2.9	3.8
Medication: Seretide 50 evohaler	4.8	5.5	9.4	-1.4	-3.1	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	4.7	7.2	13.8	0.7	2.7	3.7
Supplements: Fish oil (including cod liver oil)	4.7	6.2	12.0	-1.4	3.5	2.1
Hearing difficulty/problems with background noise	4.6	7.4	14.0	-0.5	2.8	3.7
Impedance of whole body	4.2	21.6	36.7	-1.4	-5.1	-6.1
Qualifications: nursing, teaching	4.0	6.2	10.9	-2.7	3.3	0.6
Mean time to correctly identify matches	3.9	7.4	18.0	0.8	-4.2	-1.9
Vitamin and mineral supplements	3.8	5.2	11.2	-0.8	-3.4	-1.9
Tense / ‘highly strung’	3.8	6.4	9.7	-3.1	2.4	2.0
Blood Red Count	3.7	35.6	62.4	3.2	5.8	7.9
Reason for reducing amount of alcohol drunk: Health precaution	3.7	4.3	7.6	-0.9	2.8	2.1
Medication: Omeprazole	3.7	4.4	5.7	1.7	2.4	2.2
Forced expiratory volume in 1-second (FEV1), predicted	3.7	7.7	15.2	0.6	-2.8	-3.9
Other serious medical condition/disability diagnosed by doctor	3.5	4.6	9.2	3.0	0.9	1.9
Number of incorrect matches in round	3.5	5.9	8.9	-3.0	2.6	1.4
Schizophrenia (2018)	3.3	6.8	10.8	0.6	3.0	3.3
Mineral and other dietary supplements	3.3	4.4	10.9	0.4	-3.3	-1.5
Schizophrenia vs Biploar Disorder	3.2	4.2	5.3	1.7	-2.1	-2.3
Gout (self-reported)	3.2	4.3	11.3	-0.5	-1.2	-3.4
Supplements: Glucosamine	3.1	4.1	6.5	2.0	2.5	1.4
Reaction Time	3.0	5.6	13.3	-0.2	-3.6	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	3.0	3.2	5.0	1.3	1.7	2.2
Breast Cancer	2.9	6.9	12.0	-2.3	3.5	1.9
Past tobacco smoking	2.9	5.3	7.5	-2.2	-1.9	-2.7
Lung FVC	2.8	14.4	38.8	0.0	6.2	2.1
Bilateral oophorectomy (both ovaries removed)	2.8	3.3	8.7	3.0	-1.0	0.3
Alzheimer’s Disease (in father)	2.7	2.9	5.0	-0.2	-1.9	-2.2
Fed-up feelings	2.7	4.9	9.1	0.8	-3.0	-2.2
Long-standing illness, disability or infirmity	2.7	4.2	11.3	3.4	-0.8	0.7
Average weekly champagne plus white wine intake	2.7	3.7	6.9	-2.6	2.0	-0.0
Unable to work because of sickness or disability	2.7	3.5	4.2	1.4	-2.0	-2.1
Stomach or abdominal pain in last month	2.6	3.3	4.5	-1.2	2.1	1.9
Medication for pain relief, constipation, heartburn	2.6	4.4	6.9	0.1	-2.6	-2.5
Ever smoked	2.6	4.6	6.4	1.8	2.5	2.0
Allergy or Eczema	2.5	6.5	14.8	-1.0	3.8	1.9
Diverticular disease/diverticulitis (self-reported)	2.5	3.0	5.0	-1.0	2.2	1.7
Body mass index (BMI)	2.5	10.6	15.6	3.1	2.6	4.0
Number of treatments/medications taken	2.4	4.3	7.2	2.1	1.1	2.7
Qualifications: CSEs or equivalent	2.4	3.1	6.0	-0.4	-1.8	-2.4
Nervous feelings	2.4	4.5	6.1	-2.5	-1.5	-2.2
Multivitamins +/- minerals	2.3	2.9	6.8	0.8	2.6	1.1
Ever had hysterectomy (womb removed)	2.2	2.5	3.3	1.8	-1.8	1.0
Hair/balding pattern: Pattern 3	2.2	3.3	6.0	0.4	2.4	2.0
Impedance of arm (left)	2.2	10.3	15.6	-2.2	-3.2	-4.0
Standing height	2.2	21.3	49.7	0.6	-3.7	-7.0
Ever highly irritable/argumentative for 2 days	2.2	2.6	5.7	-2.4	0.7	1.3
Health satisfaction	2.2	2.9	6.0	2.5	-0.0	1.6
Number of full sisters	2.2	2.7	4.0	2.0	1.4	1.5
Medication: Gliclazide	2.2	2.5	4.5	1.7	-0.1	2.1
Schizophrenia (2014)	2.1	4.7	7.3	1.1	2.4	2.7
Smoking Status	2.1	5.0	7.7	2.8	2.0	1.8
Alcohol usually taken with meals	2.1	3.4	9.2	-0.7	3.0	0.7
Arm fat percentage (right)	2.1	8.1	12.1	2.9	2.0	3.5
Prostate Cancer	2.0	2.8	3.7	-1.3	1.7	1.9
Ulcerative Colitis	2.0	2.9	7.1	-0.9	0.9	2.7
Cardiovascular Disease	2.0	6.5	14.7	3.8	0.5	2.1
Waist circumference	2.0	7.5	17.1	4.1	1.7	1.5
Shortness of breath walking on level ground	2.0	2.4	2.9	1.7	1.2	1.6
Triglycerides	1.9	3.1	5.3	1.1	-2.3	-1.6
BMI	1.9	11.1	18.7	2.7	2.7	4.3
Waist Hip Ratio (WHR)	1.9	8.6	25.1	5.0	0.7	0.0
Diabetes (father)	1.9	2.3	6.2	2.5	-0.9	-0.2
Pack years adult smoking proportion	1.9	2.9	5.7	2.4	-0.7	-1.6
Allergy	1.9	4.3	7.4	-0.5	-2.7	-2.3
Overall health rating	1.9	4.0	8.7	3.0	0.7	1.7
Friendships satisfaction	1.9	2.3	3.3	-1.4	1.3	1.8
Pain type(s) experienced in last month: Hip pain	1.9	2.4	7.0	2.6	-0.1	-0.3
Age at First Birth	1.8	2.6	4.0	0.9	-1.7	-2.0
Hand grip strength (right)	1.8	4.8	12.7	-0.7	-1.1	-3.6
Blood clot in the leg (DVT)	1.8	2.3	6.3	2.5	-0.8	-0.0
Arm fat percentage (left)	1.8	7.3	10.6	2.8	1.9	3.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	6.2	2.5	-0.9	-0.2
Worry (Nagel 2018)	1.7	3.6	7.0	-2.6	1.5	1.2
Hand grip strength (left)	1.7	4.4	7.8	-2.2	0.8	-2.8
Medication: Blood pressure	1.7	3.2	5.2	2.0	-2.3	-0.8
Risk taking	1.7	2.5	5.0	1.4	2.2	0.9
Supplements: Calcium	1.7	1.9	5.2	-0.3	2.3	0.7
Alcohol drinker status: Previous	1.7	1.9	2.8	1.6	0.7	1.7
Height	1.6	31.5	77.1	-1.3	-4.0	-8.8
Type 2 Diabetes (T2D) (2018)	1.6	3.1	9.0	3.0	0.5	0.2
Lung cancer (father)	1.6	1.9	4.8	-0.7	-2.2	-0.5
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.8	1.3	1.9	0.5
Suffer from ‘nerves’	1.6	2.6	4.9	-2.2	1.6	0.6
Chest pain or discomfort	1.6	2.3	3.6	-1.0	1.9	1.5
Smoking status: Previous	1.6	2.4	4.8	1.5	0.5	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	7.8	-0.4	2.8	1.5
Pack years of smoking	1.6	2.4	4.4	2.1	-0.7	-1.5
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.3	2.1	0.4	0.5
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.9	-1.3	2.6	1.0
Had other major operations	1.5	1.8	5.0	2.2	-0.7	-0.1
Impedance of arm (right)	1.5	6.9	11.0	-1.5	-2.7	-3.3
Qualifications: A levels/AS levels or equivalent	1.5	3.4	6.0	-1.4	2.4	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.6	-0.3	1.9	1.4
Arm fat mass (right)	1.5	6.2	9.7	3.1	1.6	2.5
Exposure to tobacco smoke outside home	1.5	2.0	4.4	-0.9	-0.8	-2.1
Pulse wave peak to peak time	1.5	1.7	3.4	-0.8	-1.1	-1.9
Taking other prescription medications	1.4	2.2	4.3	2.1	0.1	1.5
Serious illness, injury or assault to yourself	1.4	1.7	4.8	2.2	-0.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.4	-2.1	1.3	0.7
Pulse rate	1.4	2.3	5.7	0.3	1.0	2.4
Birth weight of first child	1.4	2.6	7.0	-2.6	0.8	-0.4
Number of full brothers	1.4	1.8	3.3	-1.3	1.8	0.6
Wheeze or whistling in the chest in last year	1.4	2.5	4.4	0.6	1.7	2.1
Alcohol intake frequency.	1.4	3.2	5.1	2.3	-2.1	-0.3
Comparative height size at age 10	1.4	7.5	17.5	1.0	-2.0	-4.2
Arm fat mass (left)	1.4	5.8	9.1	3.0	1.6	2.4
Number of self-reported non-cancer illnesses	1.4	2.4	5.3	2.3	-0.0	1.4
Vascular/heart problems diagnosed by doctor	1.4	3.8	8.4	-2.9	-0.4	-1.7
Ulcerative Colitis (UC)	1.3	2.4	5.8	-1.0	0.6	2.4
Financial difficulties in last 2 years	1.3	1.7	3.8	2.0	1.1	0.3
Hypertension (Self-reported)	1.3	3.6	8.2	2.9	-0.7	1.5
Cholesterol lowering medication	1.3	1.9	4.6	2.1	-1.0	-0.3
Crohns Disease (2012)	1.2	2.0	3.6	-1.3	0.8	1.9
Hypothyroidism (self reported)	1.2	2.8	4.8	0.2	-1.9	-2.2
Medication: Metformin	1.2	1.7	5.1	2.3	-0.1	0.3
Townsend deprivation index at recruitment	1.2	1.6	4.8	2.2	0.4	-0.0
High blood pressure	1.2	3.4	8.4	2.9	-0.5	1.2
Leg fat percentage (right)	1.2	4.4	12.8	3.6	0.2	0.5
Leg fat mass (right)	1.2	4.6	12.5	3.5	0.7	0.9
Diabetes diagnosed by doctor	1.2	1.9	4.9	2.2	-0.9	0.3
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	2.7	-1.5	-1.0	-1.6
Hearing aid user	1.2	1.3	2.9	-1.7	0.4	1.0
Rheumatoid Arthritis	1.1	1.5	2.2	0.8	-1.3	-1.5
Heel T-Score	1.1	8.8	13.6	-2.7	-2.4	-3.7
Asthma	1.1	2.2	5.3	0.4	1.1	2.3
Exposure to tobacco smoke at home	1.1	1.2	1.6	0.8	-1.2	-1.3
Migraine (self-reported)	1.1	1.3	1.9	1.4	-0.6	1.3
Asthma (self-reported)	1.1	2.1	5.5	-0.1	0.9	2.3
Illnesses of father: None of the above (group 1)	1.1	1.4	2.2	-0.9	-1.5	-1.1
Leg fat percentage (left)	1.1	4.1	11.1	3.3	0.6	0.8
Number of operations (self-reported)	1.1	1.7	2.9	1.7	-1.1	1.0
Irritability	1.1	1.9	4.9	-0.2	2.2	0.8
Fractured/broken bones in last 5 years	1.1	1.4	2.0	1.2	0.8	1.4
Leg fat mass (left)	1.1	4.4	10.9	3.3	1.0	1.2
Primary Biliary Cirrhosis	1.0	1.5	2.4	-1.5	-1.4	-0.5
Systolic Blood Pressure	1.0	4.8	8.9	3.0	-2.1	-1.1
Relative age of first facial hair	1.0	2.1	6.1	-0.2	0.4	2.5
Current tobacco smoking	1.0	1.7	4.9	2.2	0.0	-0.3
Average weekly fortified wine intake	1.0	1.2	1.6	1.3	0.6	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.4	-1.5	1.0	0.1
Mouth/teeth dental problems: Dentures	1.0	1.7	4.8	2.2	-0.3	-0.2
Depression (self-reported)	1.0	1.2	1.9	-0.9	1.0	1.4
Pulse wave Arterial Stiffness index	1.0	1.2	2.1	0.8	1.0	1.4
Medication: Ibuprofen	1.0	1.2	2.3	0.4	1.5	1.1
Had major operations	1.0	1.2	1.7	-1.3	1.0	0.8
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.7	-1.6	0.2	-0.8
Illnesses of father: Heart disease	1.0	1.4	2.7	1.0	1.7	0.7
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.4	1.6	0.0	1.1
Eye problems/disorders: Glaucoma	1.0	1.2	2.0	1.4	-1.2	-0.4
Myopia	1.0	1.4	1.7	1.2	1.3	1.1
Heart disease (siblings)	1.0	1.3	2.8	-1.7	-0.8	-0.5
Alzheimer’s Disease (including proxy)	0.9	1.2	2.2	0.7	-1.0	-1.5
Body Mass Index (BMI) (2010)	0.9	1.2	3.1	1.8	-0.5	-0.5
HbA1C	0.9	1.0	3.0	0.2	-1.7	-0.3
LDL Cholesterol	0.9	1.4	3.1	1.8	-0.8	0.6
Average weekly spirits intake	0.9	1.1	2.5	1.6	-0.7	0.4
Supplements: Zinc	0.9	1.0	1.9	1.4	0.7	0.7
Medication: Levothyroxine sodium	0.9	1.6	3.8	-0.3	-1.0	-1.9
Forced vital capacity (FVC)	0.9	3.3	6.4	0.3	1.8	-2.5
Father’s age at death	0.9	1.2	1.8	-0.8	1.3	1.1
Happiness	0.9	1.1	1.8	-0.4	1.2	1.3
Number of children fathered	0.9	1.0	2.3	-1.5	0.9	0.0
Age at first live birth	0.9	1.7	3.8	-1.9	0.8	-0.8
Heart disease (mother)	0.9	1.1	2.1	-1.1	1.5	-0.3
Whole body fat mass	0.9	3.9	10.6	3.3	0.4	0.9
Leg pain on walking	0.9	1.1	2.0	1.4	0.5	1.0
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.4	-0.9	0.3	1.6
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.4	-0.9	1.1	1.2
Commuting to job workplace: Public transport	0.9	1.1	1.2	1.0	1.1	1.1
Sensitivity / hurt feelings	0.8	1.3	2.1	-1.3	1.4	0.3
Diabetes (self-reported)	0.8	1.2	2.2	1.5	-1.1	-0.2
Alcohol intake versus 10 years previously	0.8	1.2	2.0	1.1	-0.5	-1.4
Falls in the last year	0.8	1.1	1.7	0.3	1.3	1.2
Prospective memory result	0.8	1.0	2.7	-1.6	-0.2	0.4
Leg fat-free mass (right)	0.8	4.1	6.6	1.5	2.6	1.9
Medication for cholesterol	0.8	1.2	2.0	-1.0	1.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.7	-0.0	1.6	0.4
Smoking status: Current	0.8	1.2	3.3	1.8	0.6	-0.1
Leg predicted mass (right)	0.8	4.2	6.8	1.5	2.6	1.9
Wears glasses or contact lenses	0.8	0.9	1.3	1.1	0.8	0.9
Mother’s age at death	0.8	1.0	1.5	-0.9	1.2	0.8
Irritable Bowel Disease (IBD)	0.7	1.6	4.4	-0.7	0.1	2.1
HDL Cholesterol	0.7	1.2	3.6	-1.9	-0.1	-0.3
Blood Platelet Count	0.7	7.9	13.2	-3.6	2.5	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.3	-1.5	-0.6	-1.4
Sitting height	0.7	4.6	8.8	1.6	-1.5	-3.0
Trunk fat mass	0.7	3.1	8.9	3.0	0.3	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.8	-1.7	-0.6	-1.4
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.6	-0.9	1.3	-0.5
Medication: Simvastatin	0.7	1.0	1.7	1.3	-1.1	-0.5
Weight	0.7	3.7	9.7	3.1	0.9	0.7
Number of live births	0.7	0.9	1.9	0.9	0.3	1.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.1	0.2	1.7	-2.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.9	-0.3	-1.0	-1.7
Birth weight	0.7	1.5	4.0	0.7	0.1	2.0
Forced vital capacity (FVC), Best measure	0.7	2.6	4.2	0.1	1.9	-2.0
Body fat percentage	0.7	2.9	7.8	2.8	0.2	0.9
Age at last live birth	0.7	1.1	2.2	-0.8	1.5	0.6
Family relationship satisfaction	0.7	0.8	1.6	-1.3	-1.0	0.2
Blood White Count	0.6	4.7	13.1	-0.6	3.6	0.8
Hair Pigment	0.6	17.4	27.2	-3.6	5.2	3.5
Medication: Co-codamol	0.6	0.7	1.9	0.5	-1.4	0.2
Severe depression (siblings)	0.6	0.7	1.2	0.3	0.9	1.1
Leg fat-free mass (left)	0.6	3.0	4.0	1.8	2.0	1.4
Trunk fat percentage	0.6	2.2	6.4	2.5	-0.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.4	0.0	2.1	-1.2
Peak expiratory flow (PEF)	0.6	1.4	2.3	0.8	1.5	-1.1
Glaucoma (self-reported)	0.6	0.7	1.3	1.1	-0.8	-0.4
Loneliness, isolation	0.6	0.8	2.4	1.5	-0.1	0.1
Ever had bowel cancer screening	0.6	0.8	1.3	-0.4	0.9	1.1
Breast cancer (self-reported)	0.6	0.7	0.7	-0.8	-0.8	-0.9
Ever taken oral contraceptive pill	0.6	0.7	1.5	-0.4	1.2	-0.7
High cholesterol (Self-reported)	0.6	1.1	3.2	1.8	-0.1	0.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.2	1.5	0.2	-0.1
Lung FEV1/FVC ratio	0.5	2.8	4.6	-1.3	-2.1	-1.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	-1.1	-0.9	0.0
Age when periods started (menarche)	0.5	1.2	3.3	-1.8	-0.3	-0.4
Leg predicted mass (left)	0.5	2.7	3.7	1.7	1.9	1.3
Mouth/teeth dental problems	0.5	0.8	2.2	-1.5	0.1	-0.4
Heart attack	0.5	0.6	1.7	1.3	0.2	-0.3
Worrier / anxious feelings	0.5	0.9	2.5	-1.6	0.3	0.2
Noisy workplace	0.5	0.7	2.0	0.2	-1.4	0.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.5	-0.8	1.2	0.5
Medication: Paracetamol	0.5	0.8	0.9	-1.0	0.8	1.0
High blood pressure (siblings)	0.5	0.7	1.5	-0.2	1.2	0.7
Medication: Blood pressure	0.5	0.9	1.6	-0.0	1.0	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-0.3	1.3	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	-0.4	-1.2	-0.5
Osteoporosis (self-reported)	0.5	0.6	1.7	1.3	-0.0	0.2
Osteoarthritis (self-reported)	0.5	0.7	1.2	0.5	-0.8	-1.1
Alcohol drinker status: Never	0.5	0.6	0.8	-0.9	-0.6	0.9
Age started oral contraceptive pill	0.5	0.6	1.0	0.9	0.2	1.0
Blood Eosinophil Count	0.4	2.8	8.1	-0.4	-0.3	-2.9
Respiratory disease	0.4	0.8	2.3	0.0	0.3	1.5
Systolic blood pressure, automated reading	0.4	1.2	2.6	1.6	-1.0	0.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.2	0.3	1.1	0.4
Medication for hormone replacement therapy	0.4	0.5	1.1	-1.0	0.6	0.3
Medication: Atenolol	0.4	0.5	1.0	1.0	0.6	-0.2
Had menopause	0.4	0.5	0.9	0.9	-0.8	0.1
Hip circumference	0.4	1.7	2.6	1.6	1.3	0.8
Time employed in main current job	0.4	0.5	0.9	0.7	-0.1	-0.9
Length of working week for main job	0.4	0.4	0.9	0.5	-1.0	-0.2
Eye problems/disorders: None of the above	0.4	0.5	1.1	0.3	-1.0	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.0	1.0	0.6	0.1
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.4	1.1	-0.0
Whole body fat-free mass	0.4	2.1	3.5	1.6	1.9	0.6
Commuting to job workplace: Walk	0.4	0.4	0.5	0.7	0.6	0.7
Whole body water mass	0.4	2.4	3.5	1.8	1.9	0.7
Guilty feelings	0.4	0.7	1.4	-1.2	0.3	0.7
Medication: Bendroflumethiazide	0.4	0.7	1.0	1.0	-0.2	1.0
Basal metabolic rate	0.4	2.5	4.0	2.0	1.7	0.6
Ever depressed for a whole week	0.4	0.5	0.8	0.9	-0.4	0.7
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	1.2	-0.2	0.0
Arm predicted mass (left)	0.4	1.8	4.7	2.2	0.9	-0.1
Depressed Affect (Nagel 2018)	0.3	0.5	1.2	1.1	-0.3	-0.6
Depression (Nagel 2018)	0.3	0.4	0.6	-0.4	0.8	0.7
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.0	-0.5	0.4	-1.4
Neuroticism (Nagel 2018)	0.3	0.7	1.0	-0.8	1.0	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	0.8	0.7	0.0
Ovarian Cancer	0.3	0.4	0.8	-0.0	0.7	0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.5	0.5	-0.6	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	1.0	-0.5	-0.2
Angina	0.3	0.4	1.1	-0.0	1.0	-0.0
Diabetes (mother)	0.3	0.4	0.8	0.9	0.6	-0.4
Maternal smoking around birth	0.3	0.4	0.5	0.7	-0.7	0.5
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.5	0.3	0.8
Pain all over the body in last month	0.3	0.4	0.7	0.6	-0.3	-0.8
Medication: Ramipril	0.3	0.3	1.0	0.1	0.1	1.0
Illnesses of siblings	0.3	0.4	0.9	0.9	-0.5	-0.3
Neuroticism score	0.3	0.7	2.0	-1.4	0.3	-0.2
Trunk fat-free mass	0.3	1.4	2.3	1.4	1.5	-0.1
Illnesses of mother	0.3	0.4	1.2	-0.1	-1.1	-0.2
Loud music exposure frequency	0.3	0.3	0.6	-0.7	0.1	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	-1.0	-0.1	-0.7
Medication: Amlodipine	0.3	0.4	1.0	0.1	1.0	0.4
Arm fat-free mass (right)	0.3	1.7	4.5	2.1	0.6	-0.6
Comparative body size at age 10	0.3	0.7	1.6	0.7	-1.3	0.1
Worry too long after embarrassment	0.3	0.5	1.0	-0.4	-1.0	0.5
Neck or shoulder pain in last month	0.3	0.4	1.0	0.1	-0.3	-1.0
Angina (self-reported)	0.3	0.4	1.2	-0.1	1.1	-0.0
Arm predicted mass (right)	0.3	1.5	3.7	1.9	0.9	-0.4
Miserableness	0.3	0.5	1.3	0.6	1.1	-0.1
Financial situation satisfaction	0.3	0.4	0.6	0.2	-0.7	-0.8
Medication: Paracetamol	0.3	0.5	1.1	-0.3	0.6	1.1
Illnesses of father: High blood pressure	0.3	0.4	0.7	0.4	0.8	0.5
Arm fat-free mass (left)	0.3	1.7	3.8	1.9	1.1	-0.1
Crohns Disease (2017)	0.2	0.5	1.0	-0.5	-0.4	1.0
Major Depression (MDD)	0.2	0.2	0.6	0.4	-0.8	-0.0
Mean Putamen Volume	0.2	0.2	0.3	-0.4	-0.5	-0.5
Fasting Glucose	0.2	0.2	0.3	0.5	0.6	-0.2
Lupus	0.2	0.4	0.6	-0.6	0.8	-0.3
Neuroticism	0.2	0.5	0.7	-0.8	0.7	0.4
Relative age voice broke	0.2	0.3	0.5	-0.7	-0.1	0.7
High blood pressure (mother)	0.2	0.3	0.7	-0.8	0.4	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.6	-0.1	0.5
Medication: Lansoprazole	0.2	0.2	0.6	0.2	0.8	0.2
Trunk predicted mass	0.2	1.4	2.4	1.3	1.5	-0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.1	0.6	-0.5
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.7	0.1	0.1
Pulse rate, automated reading	0.2	0.5	0.7	0.6	-0.8	0.6
Medication: Aspirin	0.2	0.2	0.3	0.3	0.5	0.6
Back pain experienced in last month	0.2	0.3	0.5	0.7	0.2	-0.7
Medication: Atorvastatin	0.2	0.3	0.7	-0.2	-0.1	-0.9
Diastolic blood pressure, automated reading	0.2	0.6	1.0	1.0	-0.9	-0.4
Pain experienced in last month	0.2	0.3	0.4	-0.6	-0.6	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	0.3	-0.2	-0.8
Tanning	0.1	1.4	2.4	-0.3	-1.6	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	-0.7	0.1	-0.2
Hair/balding pattern: Pattern 2	0.1	0.2	0.2	0.5	-0.4	-0.4
Fluid intelligence score	0.1	0.2	0.4	-0.3	-0.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.3	-0.0	0.6
Breastfed as a baby	0.1	0.2	0.3	-0.6	-0.3	0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.7	0.8	-0.3	0.1
Pulse wave reflection index	0.1	0.1	0.1	0.4	0.2	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	0.6	-0.3	0.1
Headache pain in last month	0.1	0.2	0.3	0.4	-0.0	0.6
Supplements: Vitamin C	0.1	0.2	0.5	-0.1	0.7	-0.1
Knee pain experienced in last month	0.1	0.1	0.2	0.3	0.5	-0.4
Mood swings	0.1	0.2	0.5	0.7	0.3	-0.1
Medication: Aspirin	0.1	0.2	0.3	-0.2	0.4	0.6
Average weekly beer plus cider intake	0.1	0.2	0.5	0.4	-0.2	-0.7
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	-0.3	-0.2	0.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	-0.1	0.0
Neuroticism (2016)	0.0	0.1	0.1	-0.2	0.1	0.3
Medication: Cholesterol lowering	0.0	0.1	0.1	0.4	0.0	-0.2
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	-0.2	-0.1	-0.2
Eye problems/disorders: Cataract	0.0	0.1	0.1	0.2	0.2	0.2
Medication: Lisinopril	0.0	0.0	0.1	-0.2	0.1	-0.1

Hub : Genes

BRMS1

Models

Trait associations