Hub : Genes

C11orf92

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0250	0.0085	7.8e-05	0.004	0.012	0.011	0.012	0.005	0.01000	5.8e-05	0.00011	6.8e-05	0.0059
2	TCGA	Colon Adenocarcinoma	0.0770	0.0420	8.1e-03	0.049	0.010	0.020	NA	0.021	0.00078	7.7e-02	0.02500	NA	0.0220
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0386	0.0186	4.9e-04	0.005	0.021	0.015	NA	0.011	0.09100	1.7e-03	0.00670	NA	0.0200
4	TCGA	Liver Hepatocellular Carcinoma	0.0920	0.0530	3.8e-03	0.040	0.041	0.020	NA	0.037	0.00580	5.3e-03	0.03900	NA	0.0077
5	TCGA	Prostate Adenocarcinoma	0.0320	0.0161	4.8e-04	0.021	0.021	0.007	NA	0.013	0.00250	2.5e-03	0.05700	NA	0.0150

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.4	3.2	0.7	-1.8	0.4	0.9	-1.5
Bipolar Disorder or Schizophrenia	0.4	1.0	2.1	0.9	-1.4	-0.2	0.5	-1.3
Depressed Affect (Nagel 2018)	0.5	1.0	1.5	-0.3	0.9	-1.1	-1.1	1.2
Depression (Nagel 2018)	0.4	0.6	1.9	1.4	-0.1	1.0	0.6	0.1
Intelligence (Savage-Jansen 2018)	1.1	3.5	13.6	3.7	1.2	-0.7	-0.8	1.1
Neuroticism (Nagel 2018)	0.5	1.2	1.8	-0.1	1.0	-1.2	-1.3	1.3
Schizophrenia (2018)	0.1	0.2	0.4	0.7	-0.4	-0.6	-0.1	-0.4
Schizophrenia vs Biploar Disorder	1.0	1.3	2.7	-0.2	-0.9	1.4	1.6	-1.0
Worry (Nagel 2018)	0.8	1.6	3.3	-0.6	1.5	-0.8	-1.2	1.8
Alzheimer’s Disease (in mother)	0.3	0.3	1.1	-0.2	0.3	-1.0	-0.2	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.6	-0.2	0.2	-0.1	-0.6	0.8
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.5	0.3	0.3	0.1	0.3
Crohns Disease (2017)	0.3	0.7	1.7	-1.2	-1.3	-0.6	-0.1	0.1
Irritable Bowel Disease (IBD)	0.6	1.4	5.3	-2.3	-0.7	-1.0	-0.1	0.3
Ulcerative Colitis (UC)	0.7	1.3	5.4	-2.3	-0.5	-0.9	0.1	0.1
Major Depression (MDD)	0.6	0.8	1.5	0.7	-1.1	-0.8	0.1	-1.2
Reaction Time	0.5	0.9	2.4	1.5	-0.7	1.1	0.4	-0.0
Verbal and Numeric Reasoning (VNR)	1.1	2.6	3.6	1.5	1.9	-1.4	-1.5	1.7
Breast Cancer	1.2	3.0	7.3	-1.4	2.7	-0.4	-1.1	2.0
Ovarian Cancer	0.8	1.0	2.1	0.4	-0.8	1.1	1.1	-1.5
Prostate Cancer	0.8	1.2	5.7	-2.4	0.1	-0.3	-0.3	-0.1
Age at First Birth	0.4	0.6	1.5	0.3	0.1	1.2	0.9	-0.8
Bipolar Disorder (2011)	0.4	0.4	1.3	0.4	-0.4	-0.6	-1.2	0.2
Body Mass Index (BMI) (2010)	1.2	1.6	5.0	-2.2	1.2	0.1	-0.7	1.2
Coronary Artery Disease (CAD)	0.5	0.6	1.5	-1.1	-0.3	-1.2	0.1	0.3
Crohns Disease (2012)	1.8	2.8	7.8	-0.4	-2.8	0.9	1.6	-1.7
Mean Putamen Volume	0.3	0.4	0.7	-0.8	0.2	-0.8	-0.6	-0.2
Fasting Glucose	2.9	3.4	5.0	-1.3	2.0	-2.2	-1.8	1.8
HbA1C	4.1	4.5	9.8	-1.7	3.1	-1.5	-1.5	2.3
HDL Cholesterol	0.2	0.3	0.7	-0.2	0.5	-0.3	-0.5	0.8
LDL Cholesterol	1.3	2.1	3.9	-0.7	-1.0	1.1	2.0	-1.9
Lupus	0.5	0.8	1.6	-1.1	-0.0	0.1	1.3	-1.0
Neuroticism (2016)	0.0	0.0	0.1	-0.0	0.2	0.1	0.2	0.3
Primary Biliary Cirrhosis	0.9	1.2	3.3	1.4	0.7	1.8	0.5	-0.2
Rheumatoid Arthritis	0.1	0.2	0.5	0.5	0.1	0.3	0.7	-0.3
Schizophrenia (2014)	0.4	0.8	1.4	0.9	-1.1	0.4	0.8	-1.2
Triglycerides	0.1	0.2	0.5	-0.5	-0.2	-0.7	-0.4	-0.3
Type 2 Diabetes (T2D) (2012)	1.7	2.0	4.5	-2.1	0.5	-1.1	-1.4	1.3
Ulcerative Colitis	0.6	0.9	3.4	-1.9	-0.8	-0.7	0.3	-0.2
Blood Eosinophil Count	0.7	5.5	20.5	-4.5	-0.6	-2.2	1.0	0.9
Blood Platelet Count	0.3	3.9	6.6	-0.6	1.0	-2.6	-2.4	2.4
Blood Red Count	1.1	10.2	27.7	2.1	-3.6	2.0	1.3	-5.3
Blood White Count	0.3	2.5	4.8	-1.1	1.0	-2.1	-2.2	1.1
Heel T-Score	0.3	2.3	8.5	-2.9	-0.0	-0.5	1.3	-0.9
BMI	0.5	2.9	10.6	-3.3	-1.0	1.1	1.2	-0.4
Height	0.6	11.0	21.6	4.7	-2.6	2.2	2.8	-3.7
Waist Hip Ratio (WHR)	0.4	2.0	6.8	0.8	-1.1	-1.1	-0.1	-2.6
Systolic Blood Pressure	1.1	5.3	11.2	-2.6	-0.9	3.3	2.6	-0.9
Smoking Status	1.0	2.5	5.0	-2.0	1.4	-2.2	-1.0	0.7
Allergy or Eczema	0.7	1.9	4.0	0.0	1.7	-1.5	-0.5	2.0
Cardiovascular Disease	1.5	5.0	14.3	-1.4	-1.2	3.8	2.5	-1.0
Hypothyroidism (self reported)	0.9	2.1	4.4	-1.4	1.8	0.7	-0.6	2.1
Respiratory disease	1.9	4.2	13.4	-0.0	0.8	-3.7	-2.1	1.6
Type 2 Diabetes (T2D) (2018)	2.3	4.3	6.7	-2.4	2.3	-1.4	-1.3	2.6
Lung FEV1/FVC ratio	0.4	2.2	8.5	-2.9	-0.4	0.8	0.9	-1.0
Lung FVC	0.1	0.4	1.2	0.3	0.1	0.8	0.4	-1.1
Neuroticism	0.2	0.6	0.8	-0.4	0.8	-0.8	-0.9	0.6
Chronotype (morning person)	0.2	0.4	1.1	0.1	-0.5	0.9	1.0	0.1
Hair Pigment	0.1	2.5	5.7	-2.4	1.4	-1.2	-1.5	1.2
Tanning	0.4	4.7	6.7	2.6	-1.7	2.2	2.4	-1.9
Hand grip strength (left)	1.0	2.5	4.3	2.1	-1.5	1.0	0.9	-2.1
Number of treatments/medications taken	0.7	1.3	3.6	-1.9	0.2	0.9	1.4	0.1
Average weekly spirits intake	0.5	0.6	1.1	-0.7	-0.9	0.1	1.0	-0.8
Sensitivity / hurt feelings	1.1	1.8	4.2	0.5	0.4	-2.0	-1.8	1.2
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	0.4	-0.2	-0.0	0.4	-0.0
Hearing difficulty/problems: Yes	0.9	1.3	2.7	0.4	1.2	-1.4	-0.8	1.6
Relative age of first facial hair	0.4	0.8	3.6	1.9	0.1	-0.6	-0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.2	1.1	-1.1	0.7	0.8	-0.8
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.3	-1.8	0.1	-0.1	0.6	0.3
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	-0.7	0.8	-0.2	-0.5	0.3
Systolic blood pressure, automated reading	1.1	3.2	13.5	-3.7	0.0	1.2	0.9	0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.2	-0.7	-0.6	0.6	1.1	-1.0
Angina	0.3	0.4	1.1	1.0	-1.1	-0.2	-0.0	-0.2
Medication for hormone replacement therapy	1.9	2.2	4.2	-0.4	-1.1	1.6	2.1	-1.6
Vitamin and mineral supplements	1.2	1.6	2.9	-0.5	-1.4	1.6	0.7	-1.7
Supplements: Zinc	0.7	0.8	2.1	1.4	-0.5	1.2	0.1	-0.5
Medication: Co-codamol	2.4	2.8	4.1	-1.1	2.0	-1.4	-1.8	1.9
Medication: Metformin	0.5	0.7	2.5	-1.6	-0.6	-0.6	-0.0	-0.6
Diabetes (father)	0.2	0.2	0.6	-0.3	0.7	0.3	-0.1	0.8
Diabetes (mother)	2.9	3.6	6.2	-1.2	1.5	-2.5	-2.4	1.5
Severe depression (siblings)	0.9	1.0	2.3	1.2	-1.0	0.6	-0.3	-1.5
Pack years adult smoking proportion	0.2	0.3	0.7	0.4	-0.9	-0.5	0.3	-0.5
Impedance of leg (right)	0.5	2.3	8.7	3.0	0.5	1.4	-0.3	0.5
Leg fat-free mass (left)	0.3	1.7	3.0	0.0	-1.6	0.9	1.5	-1.7
Trunk fat percentage	0.4	1.6	5.6	-2.4	-0.8	0.6	1.1	-0.5
Hand grip strength (right)	0.6	1.7	6.3	2.5	-0.9	0.2	-0.2	-1.2
Townsend deprivation index at recruitment	0.5	0.7	1.4	1.2	-0.6	0.7	1.1	-0.5
Current tobacco smoking	0.3	0.6	2.1	1.4	0.1	-0.5	0.4	0.5
Average weekly fortified wine intake	3.1	3.6	5.6	1.9	1.8	-1.4	-2.4	1.9
Maternal smoking around birth	3.2	4.6	10.7	-0.4	-3.3	0.5	1.5	-3.1
Fed-up feelings	0.6	1.1	3.3	-0.3	1.2	-0.4	-0.7	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	0.7	-0.5	0.5	0.7	-0.3
Relative age voice broke	0.1	0.1	0.3	0.6	0.3	-0.2	-0.1	-0.5
Taking other prescription medications	0.6	0.9	1.7	-1.2	1.1	-0.3	0.3	1.3
Age when periods started (menarche)	0.5	1.2	5.3	2.3	-0.2	-0.6	0.1	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.3	0.9	0.7	-0.4	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	5.2	-2.3	-0.8	0.1	0.8	-0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.3	-0.7	1.0	-1.0	-0.6	1.1
Qualifications: CSEs or equivalent	0.5	0.6	1.3	-1.1	0.2	1.0	0.9	0.3
Serious illness, injury or assault to yourself	1.8	2.2	3.9	1.0	-1.7	0.3	2.0	-1.7
High blood pressure	4.0	11.1	18.5	-3.5	-1.8	4.3	4.0	-2.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.1	1.0	0.6	-0.2	0.2	1.1
Multivitamins +/- minerals	2.7	3.4	6.4	0.0	2.0	-2.3	-1.1	2.5
Stomach or abdominal pain in last month	2.7	3.3	6.2	-0.7	1.5	-2.0	-1.9	2.5
Supplements: Glucosamine	1.5	1.9	3.9	0.2	2.0	-1.1	-1.4	1.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	5.2	-2.3	0.4	-0.4	-0.3	0.5
Medication: Atenolol	1.3	1.7	2.7	0.3	-1.2	1.2	1.6	-1.6
Medication: Levothyroxine sodium	0.5	0.8	3.0	-1.7	0.3	0.3	0.3	0.9
Sitting height	0.5	3.9	10.4	3.2	-1.0	1.6	1.4	-1.9
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	-0.3	0.2	-0.5	-0.0	0.7
High blood pressure (mother)	0.5	0.7	2.4	0.9	-0.4	1.6	0.5	0.2
Body mass index (BMI)	0.6	2.8	13.2	-3.6	-0.6	-0.1	0.4	-0.1
Impedance of leg (left)	0.4	1.9	6.4	2.5	0.6	1.5	-0.0	0.7
Leg predicted mass (left)	0.3	1.7	2.9	-0.0	-1.6	0.9	1.4	-1.7
Trunk fat mass	0.4	1.7	3.7	-1.9	-1.2	0.9	1.3	-1.0
Waist circumference	0.2	0.7	3.0	-1.7	-0.5	-0.2	0.1	-0.4
Number of incorrect matches in round	0.9	1.5	2.7	-0.5	1.3	-1.0	-1.4	1.6
Past tobacco smoking	0.8	1.5	3.9	2.0	-1.5	1.0	0.2	-0.3
Alcohol usually taken with meals	0.9	1.5	2.8	1.4	1.0	-1.2	-1.7	0.5
Nervous feelings	0.2	0.4	1.0	0.1	0.8	-0.3	-0.6	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	0.8	-0.6	1.0	0.3	-0.6
Hearing difficulty/problems with background noise	0.6	0.9	2.4	0.2	1.4	-0.3	-0.2	1.6
Hair/balding pattern: Pattern 2	1.5	1.9	3.7	1.4	1.9	0.5	-1.2	1.4
Had menopause	0.2	0.2	0.6	-0.3	-0.6	-0.1	0.8	-0.4
Had other major operations	0.2	0.3	0.8	0.4	0.4	-0.4	-0.9	-0.1
Forced vital capacity (FVC)	0.4	1.7	5.9	2.4	-0.1	1.4	0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	-0.9	-0.4	0.3	0.9	-0.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.7	1.6	-0.3	-0.3	-0.9	0.7
Qualifications: None of the above	1.5	3.2	11.7	-3.4	-1.3	0.2	1.4	-0.8
Financial difficulties in last 2 years	0.2	0.2	0.8	0.2	-0.9	0.2	0.5	0.2
Mouth/teeth dental problems	1.4	2.1	5.2	2.3	-1.0	1.3	0.7	-1.5
Heart attack	1.2	1.5	3.4	1.3	-1.8	0.1	0.9	-1.2
Allergy	0.5	1.1	2.1	-1.1	-0.6	1.3	-0.0	-1.4
Pain all over the body in last month	1.0	1.0	3.0	0.5	0.2	1.7	1.3	-0.5
Diabetes (self-reported)	2.2	3.5	4.5	-2.1	1.9	-1.8	-1.2	2.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.8	-1.3	0.3	-0.6	-0.2	0.8
Medication: Ramipril	1.2	1.5	3.3	-1.8	1.1	0.9	0.0	1.4
Medication: Simvastatin	0.2	0.3	0.9	-0.9	0.5	0.1	-0.1	0.8
Fluid intelligence score	1.7	3.6	4.6	1.9	1.9	-1.5	-2.1	1.9
Illnesses of siblings	0.9	1.2	5.6	2.4	0.0	-0.0	0.6	-0.3
Neuroticism score	0.5	1.1	2.0	-0.3	1.3	-1.1	-0.8	1.4
Weight	0.3	1.5	2.2	-1.1	-1.5	0.8	1.2	-1.4
Impedance of arm (right)	0.2	0.8	2.3	1.5	0.8	-0.6	-0.4	0.7
Arm fat percentage (right)	0.6	2.3	11.0	-3.3	-0.4	-0.5	0.1	0.1
Trunk fat-free mass	0.4	2.3	4.3	1.0	-1.8	1.1	1.3	-2.1
Hip circumference	0.2	0.7	2.8	-1.7	-0.1	0.7	0.5	0.2
Time employed in main current job	0.8	0.9	2.1	0.3	-0.0	1.4	1.4	-0.6
Alcohol intake versus 10 years previously	1.2	1.8	3.4	-0.7	0.9	-1.8	-1.8	1.0
Father’s age at death	1.1	1.5	3.4	0.2	1.0	-1.7	-1.9	0.6
Worrier / anxious feelings	0.1	0.1	0.4	-0.0	0.1	0.5	-0.1	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	4.2	0.9	-0.6	2.0	1.0	-0.1
Falls in the last year	0.4	0.5	1.9	-1.4	0.2	-0.5	0.7	-0.1
Hair/balding pattern: Pattern 3	1.0	1.5	4.7	-2.2	-1.0	-1.1	-0.5	-0.6
Number of live births	0.2	0.3	0.9	0.9	-0.2	-0.7	0.4	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.9	1.4	-0.8	2.0	0.9	-1.5
Pulse rate	0.2	0.3	0.7	-0.4	0.6	-0.5	-0.8	-0.1
Happiness	1.5	1.8	4.2	1.2	2.0	-0.1	-0.9	1.6
Noisy workplace	0.2	0.3	1.1	-0.6	0.1	1.0	0.4	-0.0
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.7	2.2	0.3	-0.5	-1.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	4.0	2.0	-0.2	0.9	0.0	-1.1
Mouth/teeth dental problems: Dentures	0.8	1.3	3.8	-1.9	-0.9	-0.1	1.4	-0.3
Asthma	1.0	1.9	3.2	0.2	0.9	-1.7	-1.5	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	0.7	1.1	0.5	-0.2	0.7
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.1	-0.5	0.5	0.4	-0.1
Depression (self-reported)	1.0	1.2	2.2	0.8	-1.5	0.5	1.1	-1.4
Medication: Lansoprazole	0.4	0.5	0.9	-0.1	0.8	-1.0	-0.9	0.5
Prospective memory result	0.5	0.6	1.1	-0.9	-0.0	-1.1	-0.2	0.9
Lung cancer (father)	1.7	2.0	9.1	3.0	-0.8	0.1	-0.2	-0.5
Illnesses of mother	1.3	1.6	2.9	-0.3	-1.0	1.3	1.7	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	5.5	2.4	-1.2	2.3	1.2	-1.9
Pulse wave Arterial Stiffness index	1.6	1.9	3.9	0.5	-1.3	1.2	1.5	-2.0
Impedance of arm (left)	0.1	0.7	2.9	1.7	0.5	-0.1	-0.0	0.4
Arm fat mass (right)	0.4	1.6	5.9	-2.4	-1.1	0.3	0.7	-0.5
Trunk predicted mass	0.4	2.3	4.2	1.2	-1.8	1.1	1.3	-2.0
Standing height	0.8	7.9	24.1	4.9	-1.8	1.8	1.6	-2.5
Length of working week for main job	0.5	0.6	1.2	-1.0	0.8	0.1	0.1	1.1
Exposure to tobacco smoke at home	0.6	0.6	1.8	-1.0	-0.4	0.3	1.4	-0.1
Breastfed as a baby	0.6	0.8	3.2	1.8	0.1	-0.6	-0.3	-0.4
Tense / ‘highly strung’	0.1	0.1	0.3	-0.2	-0.1	-0.6	-0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	1.0	0.3	0.2	0.1	0.3
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	0.8	-0.9	1.2	1.4	-1.1
Birth weight of first child	0.2	0.4	1.3	-0.2	-0.2	-1.1	-0.8	0.3
Peak expiratory flow (PEF)	0.4	1.0	2.4	0.7	-0.6	1.2	0.4	-1.6
Pulse wave reflection index	4.6	5.6	8.2	1.7	-2.1	2.9	2.6	-2.4
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	-0.9	-0.0	-1.0	-0.4	0.4
Loud music exposure frequency	0.8	0.8	1.2	1.0	1.0	-1.1	-0.8	0.7
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.7	1.9	1.4	0.8	-1.2	1.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	2.7	-1.6	1.1	-0.3	-0.8	1.2
Blood clot in the leg (DVT)	0.9	1.1	1.6	0.8	-1.2	-0.7	1.3	-1.2
Medication: Paracetamol	0.9	1.6	3.5	0.1	-0.8	1.3	1.9	-1.4
Headache pain in last month	0.1	0.1	0.4	0.7	0.5	0.1	-0.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	1.1	-0.8	-0.5	-0.1	-0.6
Glaucoma (self-reported)	0.6	0.7	2.8	-1.7	0.7	0.3	0.3	0.5
Gout (self-reported)	0.8	1.1	2.6	-1.6	-0.2	1.2	1.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.5	-1.6	1.1	1.0	0.1	1.4
Medication: Amlodipine	0.9	1.3	4.4	-2.1	-0.2	1.3	0.7	-0.3
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.9	-0.3	1.2	-1.2	-2.0	0.9
Birth weight	1.6	3.6	7.7	2.0	-2.8	0.2	1.0	-2.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.6	0.8	-0.4	-1.0	-1.3	0.2
High blood pressure (siblings)	0.8	1.2	4.4	-2.1	0.7	0.8	-0.1	0.8
Forced vital capacity (FVC), Best measure	1.1	3.8	11.0	3.3	-1.0	2.0	1.0	-1.5
Body fat percentage	0.4	1.6	7.5	-2.7	-0.5	0.3	0.6	0.0
Leg fat percentage (right)	0.4	1.3	6.1	-2.5	-0.3	0.3	0.1	0.3
Arm fat-free mass (right)	0.6	3.1	4.6	0.8	-1.8	1.9	1.8	-2.1
Exposure to tobacco smoke outside home	0.4	0.6	2.3	-1.5	0.4	-0.3	0.1	0.5
Comparative body size at age 10	0.3	0.9	2.5	-0.7	-1.0	-1.6	-0.5	-0.2
Number of full brothers	0.7	0.9	1.2	1.0	-0.8	0.7	0.9	-1.1
Worry too long after embarrassment	1.7	2.8	6.1	0.0	1.9	-2.5	-1.7	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.5	2.1	1.2	0.1	-0.8	1.6
Wheeze or whistling in the chest in last year	1.0	1.8	5.1	-0.5	1.7	-0.2	-0.9	2.3
Number of children fathered	0.5	0.5	1.3	-0.5	-1.1	0.0	0.4	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	3.8	1.9	0.0	0.9	0.3	-0.5
Age at first live birth	0.3	0.6	1.1	0.9	-0.7	0.3	0.4	-1.1
Pulse wave peak to peak time	1.4	1.6	3.3	-0.2	1.1	-1.2	-1.4	1.8
Health satisfaction	0.8	1.0	2.5	-0.9	0.5	-1.6	-0.7	1.0
Shortness of breath walking on level ground	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.5	-0.4
Qualifications: College or University degree	0.3	0.8	3.1	1.8	0.1	-0.2	-0.8	-0.5
Eye problems/disorders: None of the above	1.3	1.5	3.3	-0.4	1.1	-1.4	-1.8	1.0
Mouth/teeth dental problems: Loose teeth	5.2	6.1	11.0	-1.9	3.0	-1.6	-2.2	3.3
Emphysema/chronic bronchitis	0.4	0.5	0.8	0.9	-0.9	-0.8	0.6	0.0
Medication for pain relief, constipation, heartburn	0.6	1.1	2.5	0.5	0.5	-1.1	-1.6	1.0
Neck or shoulder pain in last month	0.9	1.3	3.4	-1.3	0.3	-1.8	-0.7	0.9
Medication: Blood pressure	1.1	1.9	3.0	-1.7	-0.4	1.7	1.5	-1.1
Angina (self-reported)	0.2	0.3	0.9	0.8	-1.0	-0.2	0.0	-0.1
Migraine (self-reported)	0.5	0.6	1.6	1.3	-0.5	0.4	-0.6	-0.8
Medication: Ibuprofen	1.2	1.4	2.6	1.5	1.6	0.5	-0.7	1.1
Medication: Allopurinol	0.7	0.9	1.6	-0.7	-0.8	1.3	0.8	-1.2
Medication: Omeprazole	1.8	2.1	4.1	-0.8	-2.0	-0.3	1.3	-2.0
Medication: Seretide 50 evohaler	1.7	1.9	4.4	-2.1	0.9	-1.4	-1.2	1.0
Mean time to correctly identify matches	0.6	1.1	2.2	0.7	-1.5	0.9	1.3	-0.6
Heart disease (mother)	0.1	0.1	0.5	-0.7	0.2	0.2	0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	-0.3	-1.1	0.2	0.9	-1.1
Whole body fat mass	0.4	1.7	5.6	-2.4	-1.1	0.7	1.1	-0.7
Leg fat mass (right)	0.3	1.2	4.4	-2.1	-0.8	0.8	0.6	-0.3
Arm predicted mass (right)	0.5	2.6	4.1	0.8	-1.4	2.0	1.6	-1.9
Pulse rate, automated reading	0.9	2.8	6.2	-0.5	1.2	-2.5	-2.2	1.0
Alcohol intake frequency.	0.2	0.5	1.5	-1.2	-0.7	-0.5	0.4	-0.5
Comparative height size at age 10	0.3	1.9	2.7	1.6	-1.4	0.4	1.5	-1.6
Number of full sisters	0.5	0.6	0.9	0.7	-0.6	-1.0	-0.9	-0.6
Suffer from ‘nerves’	1.2	1.9	3.1	-1.8	1.6	-0.8	-0.3	1.7
Overall health rating	0.5	1.1	1.8	-1.3	0.6	-1.2	-0.3	1.3
Chest pain or discomfort	0.3	0.5	2.2	1.5	0.0	0.4	-0.1	0.4
Had major operations	0.1	0.1	0.2	0.2	0.3	-0.5	-0.5	-0.1
Age at last live birth	0.1	0.2	0.6	0.8	-0.2	-0.2	0.5	0.2
Family relationship satisfaction	1.1	1.3	4.5	-0.5	0.7	-0.7	-0.9	2.1
Leg pain on walking	3.1	3.9	7.1	1.4	-1.5	2.0	2.7	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.9	0.7	-0.9	0.2	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	0.4	-0.8	0.1	0.1	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.5	0.2	-0.4	-0.5	0.7
Medication: Aspirin	0.5	0.7	2.8	-1.7	-0.6	-0.3	-0.1	-0.1
Supplements: Vitamin C	0.5	0.6	1.3	0.2	-1.1	0.2	0.8	-0.9
Knee pain experienced in last month	0.1	0.2	0.3	-0.4	-0.5	-0.5	0.4	-0.3
Hypertension (Self-reported)	3.6	10.1	17.0	-3.6	-1.6	4.1	3.8	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	-1.1	-0.1	-0.3	0.6	-0.1
Illnesses of father: Heart disease	0.8	1.1	1.9	-1.4	-0.4	1.1	1.1	-0.9
Illnesses of siblings: Diabetes	0.6	0.8	2.3	-1.5	0.9	0.3	-0.3	0.8
Smoking status: Previous	1.5	2.2	7.1	-2.7	1.6	-1.0	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	6.2	2.5	-1.6	1.9	2.0	-2.1
Whole body fat-free mass	0.3	2.0	3.6	0.5	-1.7	1.1	1.4	-1.9
Leg fat-free mass (right)	0.3	1.6	2.9	-0.2	-1.6	0.8	1.4	-1.7
Arm fat percentage (left)	0.5	2.1	10.1	-3.2	-0.3	-0.3	0.2	0.1
Average weekly red wine intake	0.8	1.1	3.1	0.3	-0.7	0.9	1.1	-1.8
Handedness (chirality/laterality): Left-handed	2.4	2.8	4.9	2.1	1.4	-1.1	-2.2	1.4
Mood swings	0.1	0.2	0.6	0.2	0.1	-0.5	-0.4	0.8
Loneliness, isolation	0.1	0.1	0.4	-0.3	0.0	-0.6	0.5	0.1
Long-standing illness, disability or infirmity	0.5	0.7	1.7	-0.7	0.8	-0.7	0.5	1.3
Ever had bowel cancer screening	0.8	1.0	2.6	0.2	-0.9	0.2	1.6	-1.2
Diabetes diagnosed by doctor	2.4	4.0	5.2	-2.3	2.2	-1.9	-1.3	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.7	1.9	1.2	-1.1	-0.8	1.3
Friendships satisfaction	1.4	1.8	4.2	-0.5	2.0	-0.3	-1.2	1.7
Qualifications: nursing, teaching	0.5	0.8	1.8	1.4	0.6	-0.7	-1.0	-0.1
Commuting to job workplace: Walk	1.5	1.6	2.8	-1.0	0.9	-1.3	-1.3	1.7
Eye problems/disorders: Cataract	0.5	0.6	1.5	0.7	-0.6	0.0	1.2	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	0.2	0.2	-0.9	-0.5	0.6
Medication for cholesterol	1.4	2.2	3.6	1.9	1.2	-1.6	-1.5	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.8	-0.2	-0.4	0.6	0.9	0.1
Back pain experienced in last month	0.6	0.9	2.5	1.6	1.1	-0.0	-0.4	0.8
Mineral and other dietary supplements	0.3	0.4	1.2	-1.1	-0.7	0.3	0.1	-0.2
Breast cancer (self-reported)	0.9	1.1	1.9	1.4	-1.2	1.0	0.7	-0.8
Asthma (self-reported)	1.1	2.2	3.7	-0.2	1.1	-1.9	-1.6	1.9
Osteoporosis (self-reported)	1.7	2.1	4.1	2.0	-1.2	0.9	1.7	-1.1
Osteoarthritis (self-reported)	0.5	0.6	1.4	-0.3	1.2	-0.1	-0.7	1.0
Medication: Aspirin	0.8	1.0	1.7	-1.2	-1.3	0.6	0.7	-1.0
Medication: Gliclazide	1.1	1.3	2.5	-1.0	-0.7	1.1	1.6	-1.1
Illnesses of father: None of the above (group 1)	1.2	1.5	5.6	2.4	-0.9	-0.4	0.3	-1.0
Smoking status: Current	0.4	0.6	2.1	1.5	0.2	-0.7	0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.7	0.4	0.5	0.5	-0.9	0.1
Whole body water mass	0.4	2.1	3.7	0.5	-1.7	1.1	1.4	-1.9
Leg predicted mass (right)	0.3	1.7	2.9	-0.2	-1.6	0.9	1.5	-1.7
Arm fat mass (left)	0.4	1.5	5.8	-2.4	-0.9	0.2	0.6	-0.4
Number of self-reported non-cancer illnesses	0.3	0.6	1.6	-1.3	0.3	-0.3	0.8	0.8
Average weekly champagne plus white wine intake	0.1	0.2	0.4	0.2	-0.4	-0.4	0.2	-0.7
Miserableness	0.4	0.6	1.1	-0.9	1.1	-0.0	-0.3	1.0
Guilty feelings	0.1	0.2	0.3	0.6	-0.1	0.5	0.2	-0.5
Wears glasses or contact lenses	0.7	0.8	1.6	-0.5	0.6	-1.3	-1.1	0.6
Ever taken oral contraceptive pill	0.5	0.6	1.4	1.1	0.3	0.3	-0.1	1.2
Hearing aid user	1.5	1.7	4.9	-1.3	1.0	-2.2	-0.9	0.5
Mother’s age at death	0.2	0.3	0.5	-0.7	-0.6	0.2	0.3	-0.5
Financial situation satisfaction	0.1	0.2	0.3	0.5	0.4	-0.2	-0.5	0.4
Tinnitus: Yes, now most or all of the time	1.8	2.1	3.4	1.2	-1.8	0.8	1.4	-1.9
Commuting to job workplace: Public transport	0.5	0.6	1.1	-0.6	0.9	-0.4	-0.8	1.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.4	-1.6	1.1	-0.5	-0.3	1.2
Medication: Blood pressure	0.8	1.5	6.6	-2.6	0.0	0.7	0.6	0.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.9	1.4	0.6	-1.1	-1.0	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	0.4	0.7	-1.1	-0.5	0.6
High cholesterol (Self-reported)	0.3	0.5	1.2	-0.3	-1.1	0.8	0.4	-0.7
Medication: Bendroflumethiazide	1.5	2.2	9.1	-3.0	1.2	-0.2	-0.2	0.7
Medication: Paracetamol	0.5	0.7	1.6	0.3	-0.1	1.3	1.2	-0.8
Medication: Lisinopril	2.2	2.8	13.2	-3.6	-0.3	-0.7	0.4	0.4
Medication: Atorvastatin	0.4	0.4	1.3	0.6	-0.5	-1.1	-0.3	-0.4
Illnesses of father: High blood pressure	1.0	1.2	2.7	-1.0	1.6	0.1	-0.8	1.3
Alcohol drinker status: Never	0.1	0.1	0.2	0.5	-0.2	-0.1	-0.2	-0.1
Ever smoked	0.8	1.3	3.1	-0.5	1.5	-1.8	-0.9	0.6
Basal metabolic rate	0.4	2.1	3.5	0.2	-1.8	1.2	1.5	-1.9
Leg fat percentage (left)	0.5	1.7	8.2	-2.9	-0.2	0.3	0.3	0.3
Arm fat-free mass (left)	0.4	1.8	2.6	0.6	-1.5	1.4	1.3	-1.6
Number of operations (self-reported)	0.3	0.5	1.1	1.1	0.1	-0.6	-0.9	-0.3
Average weekly beer plus cider intake	0.3	0.4	0.8	-0.4	-0.9	0.8	0.5	-0.2
Irritability	0.9	1.5	2.7	0.8	-1.0	1.6	1.6	-0.8
Risk taking	0.4	0.5	1.3	0.6	-0.9	-0.3	-0.2	-1.1
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.6	1.9	-0.0	-0.8	-0.5	-0.0
Fractured/broken bones in last 5 years	0.7	0.9	2.4	1.1	-0.7	-0.2	0.8	-1.6
Age started oral contraceptive pill	0.2	0.3	0.7	-0.2	0.7	-0.8	-0.2	0.4
Diastolic blood pressure, automated reading	0.7	2.3	8.4	-2.9	-0.5	1.3	1.1	0.2
Ever depressed for a whole week	0.5	0.6	1.1	0.3	0.4	-1.0	-0.8	1.0
Unable to work because of sickness or disability	1.4	1.8	2.9	1.7	-0.8	1.2	1.7	-1.0
Commuting to job workplace: Cycle	2.0	2.4	5.3	1.5	-1.9	0.1	0.9	-2.3
Myopia	0.4	0.6	1.0	0.5	0.7	-1.0	-0.9	0.5
Vascular/heart problems diagnosed by doctor	2.6	7.0	12.2	2.9	1.6	-3.5	-3.1	1.5
Cholesterol lowering medication	0.2	0.3	0.7	-0.6	-0.0	-0.8	-0.7	0.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.4	5.1	-0.9	-1.9	-0.6	1.3	-2.2
Pain experienced in last month	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2	0.0
Supplements: Calcium	0.4	0.5	2.1	1.5	0.5	0.2	0.2	0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	1.1	0.4	-0.7	-0.7	0.3
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.4	1.3	-1.8	-0.1	0.8	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.2	0.7	-1.0	-0.7	1.1	-1.0
Heart disease (siblings)	2.2	2.7	5.7	-2.4	0.5	-2.2	-1.6	0.7
Alcohol drinker status: Previous	0.6	0.7	1.8	-0.2	-0.5	0.8	1.3	-0.8
Pack years of smoking	0.3	0.5	1.0	-0.4	-1.0	-0.8	0.3	-0.7
Impedance of whole body	0.3	1.4	5.9	2.4	0.5	0.8	0.2	0.4
Leg fat mass (left)	0.4	1.6	5.8	-2.4	-0.8	0.8	0.9	-0.4
Arm predicted mass (left)	0.3	1.5	2.2	0.7	-1.3	1.2	1.2	-1.5