TWAS hub - C14orf119

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2050	0.0570	0.00035	0.117	NA	0.152	NA	0.139	4.3e-09	NA	1.7e-11	NA	1.4e-10
2	TCGA	Breast Invasive Carcinoma	0.0154	0.0085	0.00610	0.001	0.006	0.003	NA	0.001	1.7e-01	1.4e-02	7.5e-02	NA	1.6e-01
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0297	0.0154	0.00460	0.031	0.018	0.026	NA	0.025	1.8e-04	3.2e-03	5.8e-04	NA	7.7e-04
4	TCGA	Lung Adenocarcinoma	0.0555	0.0251	0.00017	0.029	0.038	0.030	NA	0.036	2.2e-04	2.6e-05	1.8e-04	NA	4.7e-05
5	TCGA	Stomach Adenocarcinoma	0.0750	0.0330	0.00049	0.068	0.037	0.048	NA	0.054	1.2e-05	1.1e-03	2.0e-04	NA	8.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Severe depression (siblings)	7.9	8.8	10.0	3.2	3.0	2.9	2.9	2.9
Age at First Birth	6.9	10.1	12.2	3.5	3.2	3.2	3.2	2.8
Supplements: Zinc	5.6	6.1	10.0	-2.3	-3.2	-2.0	-2.6	-2.1
Overall health rating	4.6	9.9	11.8	-3.1	-3.4	-3.0	-3.1	-3.0
Average weekly champagne plus white wine intake	4.5	6.2	8.0	2.4	2.8	2.5	2.1	2.6
Noisy workplace	3.9	4.8	7.2	1.1	2.7	2.3	2.3	2.3
Leg fat-free mass (right)	3.8	20.2	27.7	-4.3	-4.2	-5.2	-3.1	-5.3
Leg predicted mass (right)	3.7	19.7	27.2	-4.3	-4.1	-5.2	-3.0	-5.2
Leg predicted mass (left)	3.6	18.9	25.8	-4.1	-4.2	-5.0	-3.1	-5.1
Leg fat-free mass (left)	3.5	18.8	25.5	-4.1	-4.2	-5.0	-3.0	-5.0
Neuroticism (2016)	3.4	4.9	7.3	-2.2	-2.7	-1.9	-2.3	-1.9
Weight	3.4	16.5	20.8	-4.0	-4.1	-4.5	-2.9	-4.6
Arm fat-free mass (right)	3.4	17.5	22.2	-4.1	-4.2	-4.7	-2.9	-4.7
Basal metabolic rate	3.4	18.6	24.8	-4.1	-4.2	-4.9	-3.0	-5.0
Arm predicted mass (right)	3.3	16.9	22.0	-4.1	-4.1	-4.6	-2.8	-4.7
Whole body water mass	3.3	18.7	25.4	-4.1	-4.2	-5.0	-3.0	-5.0
Medication: Ramipril	3.2	4.1	5.4	-2.3	-2.3	-1.9	-1.6	-1.9
Whole body fat-free mass	3.2	18.5	25.1	-4.1	-4.2	-5.0	-3.0	-5.0
Arm fat-free mass (left)	3.1	15.9	22.0	-3.9	-3.9	-4.6	-2.5	-4.7
Number of full brothers	3.0	3.8	5.1	2.3	2.2	2.0	0.9	2.0
Trunk fat-free mass	2.9	16.7	22.4	-3.8	-4.0	-4.7	-2.9	-4.7
Medication: Blood pressure	2.9	5.1	6.5	-2.4	-2.6	-2.3	-1.8	-2.3
Number of self-reported non-cancer illnesses	2.9	5.0	6.5	-2.2	-2.5	-2.1	-2.2	-2.1
Relative age of first facial hair	2.8	5.8	7.3	2.3	2.4	2.3	2.7	2.3
Trunk predicted mass	2.8	16.2	21.7	-3.8	-4.0	-4.6	-2.8	-4.7
Had major operations	2.8	3.3	4.0	-1.8	-2.0	-1.7	-1.9	-1.6
Prostate Cancer	2.7	3.8	5.8	-2.1	-1.5	-2.4	-0.9	-2.4
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	4.9	1.8	2.2	1.8	1.6	1.8
Medication: Amlodipine	2.7	3.7	6.9	-1.7	-2.6	-1.6	-1.9	-1.6
Medication for cholesterol, blood pressure or diabetes	2.6	4.3	5.2	1.8	2.3	2.1	1.9	2.1
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.3	6.3	-2.5	-2.5	-2.5	-1.3	-2.5
Arm predicted mass (left)	2.6	13.0	17.8	-3.4	-3.5	-4.2	-2.4	-4.2
Sensitivity / hurt feelings	2.5	4.3	6.2	2.2	0.8	2.5	2.0	2.4
Illnesses of father: High blood pressure	2.5	3.1	4.5	-2.1	-1.9	-2.0	-0.1	-1.9
Systolic blood pressure, automated reading	2.4	6.9	10.9	-3.3	-2.5	-2.8	-1.4	-2.7
Townsend deprivation index at recruitment	2.4	3.3	5.4	-1.7	-2.3	-1.3	-2.2	-1.3
Medication: Ventolin 100micrograms inhaler	2.4	3.0	5.0	1.4	2.2	1.8	1.3	1.8
Age at last live birth	2.4	3.4	5.2	2.3	1.8	2.0	0.7	2.0
Serious illness, injury or assault to yourself	2.3	2.7	4.4	1.4	1.4	2.1	1.1	2.1
Trunk fat mass	2.3	10.1	12.2	-3.1	-3.4	-3.5	-2.2	-3.5
Leg fat mass (left)	2.3	9.0	10.9	-3.0	-3.1	-3.3	-2.2	-3.3
Alzheimer’s Disease (including proxy)	2.2	3.2	4.5	1.9	1.7	2.1	0.9	2.0
HDL Cholesterol	2.2	3.7	4.2	2.0	2.0	2.0	1.5	2.1
Cardiovascular Disease	2.2	7.2	9.3	-3.1	-2.6	-3.0	-1.6	-2.9
Primary Biliary Cirrhosis	2.1	3.0	4.8	-2.1	-1.0	-2.2	-0.0	-2.2
Triglycerides	2.1	3.5	5.8	-2.4	-2.0	-1.6	-1.6	-1.6
Whole body fat mass	2.1	8.8	10.9	-2.9	-3.1	-3.3	-1.9	-3.3
Bipolar Disorder or Schizophrenia	2.0	4.8	5.7	1.9	2.0	2.4	2.3	2.4
Waist circumference	2.0	7.4	9.4	-2.9	-3.1	-2.9	-1.6	-2.9
Health satisfaction	2.0	2.5	4.8	-2.2	-2.0	-1.2	-0.8	-1.2
Leg fat mass (right)	2.0	7.7	9.3	-2.7	-2.9	-3.0	-2.0	-3.0
Medication: Metformin	1.9	2.7	3.7	-1.6	-1.5	-1.9	-1.1	-1.9
Arm fat mass (right)	1.9	7.7	10.3	-2.6	-2.7	-3.2	-1.9	-3.2
High blood pressure (siblings)	1.8	2.6	4.5	-1.4	-2.1	-1.4	-1.6	-1.4
Supplements: Vitamin C	1.8	2.1	4.4	-1.0	-2.1	-1.1	-1.6	-1.1
Arm fat mass (left)	1.8	7.5	10.3	-2.6	-2.7	-3.2	-1.8	-3.2
Wears glasses or contact lenses	1.8	2.1	2.6	1.6	1.5	1.4	1.2	1.4
Schizophrenia (2018)	1.7	3.4	4.0	1.7	1.9	2.0	1.7	2.0
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	2.5	1.1	1.1	1.6	1.3	1.6
Impedance of leg (right)	1.7	8.1	12.7	2.7	2.0	3.5	2.0	3.6
Medication: Atenolol	1.7	2.2	7.7	-0.5	-1.3	-0.8	-2.8	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	4.4	-1.4	-2.1	-1.4	-1.9	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.4	1.3	1.6	1.4	0.7	1.4
Supplements: Calcium	1.7	1.9	2.6	-0.9	-1.6	-1.4	-1.5	-1.4
Systolic Blood Pressure	1.6	8.1	12.7	-3.6	-2.7	-3.0	-1.9	-2.9
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	2.6	-1.5	-1.6	-1.5	-1.0	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	4.3	-0.8	-1.9	-1.1	-2.1	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	4.9	-2.2	-1.6	-2.2	-1.4	-2.1
Hip circumference	1.6	6.9	9.2	-2.4	-2.7	-3.0	-1.8	-3.0
Sitting height	1.5	10.6	12.6	-3.2	-3.4	-3.5	-2.5	-3.6
Body mass index (BMI)	1.5	6.4	8.4	-2.5	-2.4	-2.9	-2.0	-2.9
Heart attack	1.5	1.9	2.8	1.0	1.4	1.3	1.7	1.4
Medication: Ibuprofen	1.5	1.8	3.3	1.2	1.8	1.2	1.1	1.2
Comparative height size at age 10	1.5	8.2	10.2	-3.0	-3.0	-3.2	-1.6	-3.2
Ever had prostate specific antigen (PSA) test	1.5	1.7	3.4	1.2	0.4	1.9	0.2	1.8
Diastolic blood pressure, automated reading	1.5	4.5	8.5	-2.5	-2.9	-1.8	-1.3	-1.8
Schizophrenia (2014)	1.4	3.0	4.7	1.5	1.6	1.7	2.2	1.6
Vitamin and mineral supplements	1.4	1.9	4.2	1.3	2.1	1.2	1.0	1.1
Pain all over the body in last month	1.4	1.6	4.1	-0.7	-1.4	-0.8	-2.0	-0.8
Standing height	1.4	13.5	17.8	-3.6	-4.2	-4.0	-2.2	-4.0
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	2.7	1.3	0.8	1.6	0.8	1.6
Body Mass Index (BMI) (2010)	1.3	1.7	3.0	1.3	1.7	1.3	0.7	1.4
Ever had hysterectomy (womb removed)	1.3	1.5	2.5	-1.2	-1.6	-1.2	-0.8	-1.2
Taking other prescription medications	1.3	2.0	2.9	-1.3	-1.7	-1.3	-1.4	-1.3
Forced vital capacity (FVC), Best measure	1.3	4.9	5.8	-1.8	-2.0	-2.3	-2.4	-2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.3	1.2	1.2	1.5	0.5	1.5
Medication for cholesterol	1.3	2.0	3.1	1.6	1.0	1.8	0.3	1.7
Asthma (self-reported)	1.3	2.5	3.7	1.7	1.3	1.9	0.9	1.9
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.3	1.0	1.4	1.2	1.5	1.3
Impedance of whole body	1.3	6.7	9.9	2.4	1.9	3.1	2.1	3.1
Alzheimer’s Disease (in mother)	1.2	1.4	2.2	1.4	0.6	1.5	-0.8	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	4.2	-1.8	-1.2	-2.0	-0.8	-2.0
Impedance of leg (left)	1.2	5.7	9.4	2.1	1.8	3.0	1.7	3.1
Number of incorrect matches in round	1.2	2.0	2.7	1.5	1.7	1.6	0.6	1.5
Had other major operations	1.2	1.4	2.6	-1.3	-0.9	-1.1	-1.6	-1.1
Financial difficulties in last 2 years	1.2	1.7	2.9	0.8	0.5	1.7	1.4	1.7
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	5.2	-1.7	-1.8	-2.2	-2.2	-2.3
Hypertension (Self-reported)	1.2	3.2	4.5	-1.9	-2.1	-1.8	-1.3	-1.8
Medication: Blood pressure	1.2	2.3	2.7	-1.2	-1.5	-1.6	-1.5	-1.6
Vascular/heart problems diagnosed by doctor	1.2	3.3	4.3	2.0	2.1	1.8	1.3	1.8
Major Depression (MDD)	1.1	1.4	1.7	-1.0	-1.3	-1.3	-1.0	-1.2
Ulcerative Colitis	1.1	1.6	2.2	-1.3	-1.1	-1.5	-0.8	-1.5
Blood Eosinophil Count	1.1	8.8	22.7	4.8	1.9	0.6	-4.1	0.6
Trunk fat percentage	1.1	4.3	5.5	-2.1	-2.3	-2.2	-1.3	-2.2
Current tobacco smoking	1.1	1.9	3.3	-1.4	-1.8	-0.8	-1.7	-0.8
Forced vital capacity (FVC)	1.1	4.1	4.9	-1.7	-2.1	-2.1	-2.2	-2.1
Mouth/teeth dental problems: Dentures	1.1	1.9	3.2	-1.8	-1.3	-1.4	-0.9	-1.4
Asthma	1.1	2.1	3.0	1.6	1.2	1.7	0.8	1.7
Lung cancer (father)	1.1	1.3	1.8	1.1	1.3	1.2	0.8	1.2
Shortness of breath walking on level ground	1.1	1.3	2.3	-1.3	-1.1	-0.8	-1.5	-0.8
Leg fat percentage (left)	1.1	3.8	4.8	-2.1	-2.2	-2.0	-1.4	-2.0
Alzheimer’s Disease (in father)	1.0	1.1	1.4	0.8	0.8	1.1	1.2	1.1
Hypothyroidism (self reported)	1.0	2.3	4.5	-1.1	-1.9	-1.0	-2.1	-1.1
Respiratory disease	1.0	2.3	3.2	1.7	1.4	1.8	0.5	1.8
Number of treatments/medications taken	1.0	1.8	2.0	-1.4	-1.3	-1.3	-1.4	-1.3
Impedance of arm (left)	1.0	4.8	6.7	2.1	1.6	2.5	1.9	2.6
Glaucoma (self-reported)	1.0	1.2	1.9	1.4	0.4	1.1	-1.1	1.1
Chest pain or discomfort	1.0	1.5	2.6	1.2	0.8	1.6	-0.1	1.6
Loneliness, isolation	1.0	1.4	2.0	1.4	0.7	1.3	1.0	1.4
Eye problems/disorders: Cataract	1.0	1.1	1.5	-0.8	-1.2	-1.0	-1.0	-1.1
High cholesterol (Self-reported)	1.0	1.7	2.3	-1.4	-1.1	-1.5	-0.9	-1.5
Bipolar Disorder (2018)	0.9	1.5	2.4	0.9	0.8	1.3	1.6	1.3
Irritable Bowel Disease (IBD)	0.9	2.1	2.5	-1.4	-1.5	-1.6	-1.1	-1.6
High blood pressure	0.9	2.5	3.7	-1.8	-1.9	-1.6	-1.0	-1.5
Hair/balding pattern: Pattern 2	0.9	1.1	1.6	-0.9	-0.6	-1.2	-1.3	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.7	3.8	-1.3	-1.1	-1.9	-1.8	-2.0
Length of working week for main job	0.9	1.0	1.9	1.4	0.7	1.1	-0.6	1.1
Migraine (self-reported)	0.9	1.2	1.4	1.1	0.7	1.2	1.1	1.2
Family relationship satisfaction	0.9	1.1	1.6	-1.2	-1.3	-1.1	-0.1	-1.1
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.8	-0.7	-1.1	-1.3	-0.7	-1.3
Alcohol drinker status: Never	0.9	1.1	1.6	-1.1	-0.8	-1.3	-0.7	-1.3
Relative age voice broke	0.8	1.3	2.0	1.0	0.9	1.4	0.8	1.4
Supplements: Glucosamine	0.8	1.0	1.6	1.1	0.6	1.3	0.6	1.2
Medication: Cholesterol lowering	0.8	1.2	1.5	-0.8	-1.2	-1.1	-1.1	-1.2
Depression (self-reported)	0.8	0.9	1.3	1.1	0.9	0.9	-0.9	0.9
Body fat percentage	0.8	3.2	4.0	-1.9	-2.0	-1.9	-1.1	-1.9
Age at first live birth	0.8	1.4	2.0	1.4	0.9	1.4	0.8	1.3
Long-standing illness, disability or infirmity	0.8	1.2	2.0	-1.4	-1.0	-0.9	-1.1	-0.9
Friendships satisfaction	0.8	1.0	1.8	-1.0	-1.2	-0.6	1.3	-0.6
Commuting to job workplace: Walk	0.8	0.8	1.4	0.8	1.0	0.8	1.2	0.8
Fractured/broken bones in last 5 years	0.8	1.0	1.9	1.0	0.4	1.4	-0.1	1.4
Depression (Nagel 2018)	0.7	1.1	2.2	-0.6	-1.5	-0.8	-1.3	-0.8
Ulcerative Colitis (UC)	0.7	1.3	1.9	-1.2	-1.1	-1.4	-0.6	-1.4
BMI	0.7	4.0	5.1	-1.8	-2.0	-2.3	-1.7	-2.3
Qualifications: CSEs or equivalent	0.7	1.0	1.8	1.0	0.3	1.3	-0.4	1.3
Impedance of arm (right)	0.7	3.1	4.5	1.9	1.4	2.1	1.2	2.1
Time employed in main current job	0.7	0.8	0.9	-0.9	-0.7	-1.0	-0.9	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.0	0.6	1.4	0.6	0.8	0.6
Pulse wave Arterial Stiffness index	0.7	0.9	1.7	-1.0	-1.3	-0.8	-0.4	-0.9
Leg fat percentage (right)	0.7	2.5	3.8	-1.6	-1.9	-1.6	-1.1	-1.6
Medication: Allopurinol	0.7	1.0	1.1	0.9	1.1	1.0	1.0	1.0
Pulse rate, automated reading	0.7	2.3	9.2	0.7	-0.3	0.9	3.0	1.0
Suffer from ‘nerves’	0.7	1.1	2.2	1.1	1.0	0.7	1.5	0.6
Illnesses of father: Heart disease	0.7	1.0	1.3	-1.1	-1.0	-1.1	-0.4	-1.1
Guilty feelings	0.7	1.0	1.4	1.2	0.1	1.1	1.1	1.2
Number of operations (self-reported)	0.7	1.0	1.9	-0.9	-1.4	-0.8	-1.1	-0.7
Commuting to job workplace: Cycle	0.7	0.8	2.0	-0.1	-0.9	-0.8	-1.4	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.7	1.0	1.4	0.9	1.0	0.9	1.2	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.2	0.6	0.3	0.9	0.9	1.1
Heel T-Score	0.6	5.2	9.6	-3.1	-1.6	-2.5	-1.3	-2.4
Diabetes (father)	0.6	0.8	1.8	-1.4	-0.7	-0.9	0.1	-0.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	-1.3	-0.8	-0.6	-0.1	-0.7
Arm fat percentage (right)	0.6	2.3	3.4	-1.3	-1.4	-1.8	-1.0	-1.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.3	0.3	0.6	0.9	1.2	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.0	-0.9	-1.4	-0.8	-1.3	-0.8
Worry too long after embarrassment	0.6	1.1	4.4	0.7	0.3	0.5	2.1	0.5
Angina (self-reported)	0.6	0.8	1.3	1.1	1.0	0.9	0.3	0.9
Arm fat percentage (left)	0.6	2.5	3.6	-1.5	-1.6	-1.9	-0.9	-1.9
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	1.2	0.9	0.9	-0.1	0.8
Smoking status: Current	0.6	0.9	1.9	-0.9	-1.4	-0.3	-1.2	-0.3
Eye problems/disorders: Glaucoma	0.6	0.8	2.3	0.8	-0.1	0.7	-1.5	0.6
Neuroticism (Nagel 2018)	0.5	1.2	4.4	0.6	-0.3	0.7	2.1	0.7
Worry (Nagel 2018)	0.5	1.1	4.0	0.7	0.4	0.6	2.0	0.7
Crohns Disease (2017)	0.5	1.1	1.7	-0.9	-1.3	-0.9	-1.2	-0.9
Breast Cancer	0.5	1.2	2.0	0.8	1.4	1.0	1.3	1.0
Height	0.5	9.8	13.6	-3.0	-3.7	-3.5	-1.5	-3.5
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.2	-1.1	-0.7	-1.0	-0.7	-1.0
Angina	0.5	0.6	1.0	1.0	0.9	0.8	-0.0	0.8
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.7	-0.9	-1.0	-1.3	-0.3	-1.3
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	0.7	0.2	1.0	-0.3	1.1
Mouth/teeth dental problems	0.5	0.7	2.3	1.5	0.9	0.4	0.5	0.4
Diabetes (self-reported)	0.5	0.7	1.4	-1.2	-0.8	-0.8	-0.3	-0.8
Illnesses of siblings	0.5	0.7	2.1	0.4	1.0	0.2	1.4	0.2
Neuroticism score	0.5	1.0	3.0	0.8	-0.0	0.8	1.7	0.8
Pulse rate	0.5	0.9	2.6	-0.8	-1.6	-0.6	0.7	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.5	1.1	-1.1	-0.7	-0.7	-0.3	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	1.3	-0.8	-1.0	-1.1	-0.7	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	0.4	0.9	1.0	0.4	1.0
Qualifications: nursing, teaching	0.5	0.8	1.5	-0.9	-0.4	-1.2	0.3	-1.2
Back pain experienced in last month	0.5	0.7	1.0	0.3	0.8	1.0	0.9	1.0
Financial situation satisfaction	0.5	0.7	1.4	0.6	0.2	1.2	0.2	1.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	-0.9	-1.0	-0.4	-1.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.6	-0.7	-1.3	-0.6	-0.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.9	-0.9	-1.4	-0.4	0.1	-0.5
LDL Cholesterol	0.4	0.6	0.9	-0.9	-0.5	-0.9	0.2	-0.9
Neuroticism	0.4	1.0	2.6	0.9	0.1	0.9	1.6	0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.6	0.8	0.7	0.0	0.9	-0.9	0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	-0.6	0.1	-0.9	-0.3	-0.9
Multivitamins +/- minerals	0.4	0.5	1.6	-0.7	-1.2	-0.2	-0.4	-0.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	0.4	1.1	0.6	0.8	0.6
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	-1.0	-1.1	-0.7	0.3	-0.7
Prospective memory result	0.4	0.5	0.9	-0.8	-0.3	-1.0	-0.1	-1.0
Tense / ‘highly strung’	0.4	0.7	3.1	-0.4	-0.4	-0.1	1.8	-0.1
Pulse wave reflection index	0.4	0.4	1.0	-0.6	-0.8	-0.4	-1.0	-0.4
Blood clot in the leg (DVT)	0.4	0.5	0.9	0.7	0.8	0.6	1.0	0.5
Pulse wave peak to peak time	0.4	0.5	0.9	0.7	0.9	0.6	0.3	0.7
Qualifications: College or University degree	0.4	1.1	2.0	1.2	1.1	0.7	1.4	0.8
Leg pain on walking	0.4	0.5	0.9	0.2	0.9	1.0	-0.2	0.9
Knee pain experienced in last month	0.4	0.6	1.8	-0.6	-0.8	-0.5	-1.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	0.5	0.2	1.0	0.3	1.0
Ever had bowel cancer screening	0.4	0.4	1.1	-0.4	-0.8	-0.3	-1.0	-0.4
Diabetes diagnosed by doctor	0.4	0.6	1.2	-1.1	-0.7	-0.8	-0.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.4	0.4	0.6	1.2	0.2	1.1
Hearing aid user	0.4	0.5	1.2	0.1	-0.1	1.1	-0.3	1.1
Mother’s age at death	0.4	0.5	1.0	-0.8	-0.3	-1.0	-0.2	-1.0
Medication: Lisinopril	0.4	0.5	1.6	-0.3	-0.7	-0.5	-1.3	-0.5
Ever smoked	0.4	0.8	1.0	-1.0	-0.8	-0.8	-0.8	-0.9
Age started oral contraceptive pill	0.4	0.5	0.8	-0.6	-0.6	-0.9	-0.7	-0.9
Ever depressed for a whole week	0.4	0.5	1.0	0.8	1.0	0.6	0.6	0.5
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.0	0.1	-0.7	-0.9	-1.4	-0.9
Reaction Time	0.3	0.6	1.3	-0.8	-0.7	-0.5	-1.1	-0.5
Lupus	0.3	0.4	1.0	0.4	0.6	0.5	1.0	0.4
Rheumatoid Arthritis	0.3	0.4	0.6	0.6	0.5	0.8	0.5	0.8
Hearing difficulty/problems: Yes	0.3	0.4	1.8	-0.3	0.0	0.2	1.3	0.3
Average weekly fortified wine intake	0.3	0.3	0.9	-0.3	-0.9	-0.2	-0.7	-0.2
Maternal smoking around birth	0.3	0.4	0.9	-0.4	-0.9	-0.6	-0.6	-0.6
Alcohol usually taken with meals	0.3	0.5	0.8	0.5	0.5	0.9	0.4	0.9
Hearing difficulty/problems with background noise	0.3	0.4	0.9	0.3	0.0	0.7	0.9	0.7
Breastfed as a baby	0.3	0.4	0.7	0.8	0.1	0.8	0.2	0.8
Hair/balding pattern: Pattern 4	0.3	0.8	1.4	-0.8	-0.3	-1.0	-1.2	-0.9
Birth weight of first child	0.3	0.5	1.6	0.3	0.8	0.1	1.2	0.1
Peak expiratory flow (PEF)	0.3	0.7	1.5	-0.6	-0.8	-0.7	-1.2	-0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.8	-0.4	-0.7	-0.1	-0.8
Number of children fathered	0.3	0.3	0.9	-0.9	-0.5	-0.5	-0.3	-0.5
Medication: Aspirin	0.3	0.4	1.1	0.4	0.7	0.5	1.1	0.4
Irritability	0.3	0.5	2.0	0.1	-0.5	0.4	1.4	0.4
Heart disease (siblings)	0.3	0.3	0.8	0.2	0.9	0.5	-0.5	0.6
Schizophrenia vs Biploar Disorder	0.2	0.2	0.9	0.2	0.1	-0.1	-1.0	-0.1
Ovarian Cancer	0.2	0.3	0.6	-0.0	0.1	0.8	-0.6	0.8
Crohns Disease (2012)	0.2	0.3	1.0	-0.3	-1.0	-0.5	-0.2	-0.5
Mean Putamen Volume	0.2	0.2	0.5	-0.2	-0.1	0.5	-0.7	0.5
HbA1C	0.2	0.3	0.6	-0.5	-0.7	-0.5	-0.5	-0.2
Hand grip strength (left)	0.2	0.4	0.6	0.7	0.5	0.8	0.4	0.8
Average weekly spirits intake	0.2	0.3	1.4	0.1	-0.0	-0.2	-1.2	-0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.3	-0.5	-0.5	-0.6	-0.4	-0.6
Medication: Co-codamol	0.2	0.2	0.5	0.4	0.2	0.5	-0.7	0.5
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.5	-0.8	-0.3	-0.9	-0.3
High blood pressure (mother)	0.2	0.3	0.4	-0.7	-0.3	-0.6	-0.5	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	-0.5	-0.8	-0.4	0.4	-0.4
Had menopause	0.2	0.3	0.9	0.0	0.6	0.3	1.0	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	0.5	0.5	0.2	0.8	0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.4	0.6	0.2	0.6	-0.5	0.5
Father’s age at death	0.2	0.3	0.5	-0.7	-0.3	-0.6	0.2	-0.7
Happiness	0.2	0.3	0.9	-0.4	-0.5	0.3	0.9	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.2	-0.3	0.7	-0.2	1.1	-0.2
Headache pain in last month	0.2	0.3	0.5	0.7	0.6	0.4	0.6	0.4
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.1	0.3	0.8	0.2	0.7
Comparative body size at age 10	0.2	0.5	1.4	0.8	1.2	0.3	0.5	0.3
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	0.1	0.7	0.8	0.7	0.8
Emphysema/chronic bronchitis	0.2	0.2	0.9	-0.2	-0.1	0.4	-0.9	0.4
Medication: Omeprazole	0.2	0.2	0.8	-0.4	-0.9	0.1	0.4	0.1
Medication: Seretide 50 evohaler	0.2	0.3	0.8	-0.6	0.3	-0.3	0.9	-0.3
Mean time to correctly identify matches	0.2	0.4	1.4	-0.5	-0.4	-0.0	-1.2	0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.8	0.0	0.3	-0.2	0.3
Illnesses of siblings: Diabetes	0.2	0.3	0.9	-0.4	-0.9	0.0	-0.5	-0.0
Smoking status: Previous	0.2	0.2	0.6	0.2	0.7	0.1	0.8	0.0
Mineral and other dietary supplements	0.2	0.2	0.5	0.0	0.6	0.3	0.7	0.4
Medication: Bendroflumethiazide	0.2	0.4	1.0	-0.4	-1.0	-0.5	-0.1	-0.6
Medication: Paracetamol	0.2	0.3	0.4	-0.7	0.0	-0.6	-0.2	-0.6
Myopia	0.2	0.3	0.8	-0.5	-0.3	-0.5	0.9	-0.5
Pain experienced in last month	0.2	0.3	0.8	0.5	0.7	0.1	0.9	0.1
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	0.4	-0.6	0.6	0.5	0.6
Coronary Artery Disease (CAD)	0.1	0.2	0.5	-0.1	0.1	-0.4	0.3	-0.7
Blood Platelet Count	0.1	0.8	1.3	0.9	0.7	1.1	0.3	1.2
Blood Red Count	0.1	0.8	2.2	0.3	-0.3	0.9	1.5	1.0
Waist Hip Ratio (WHR)	0.1	0.3	0.5	-0.4	-0.6	0.7	-0.1	0.7
Smoking Status	0.1	0.1	0.3	0.1	-0.1	0.6	-0.0	0.5
Allergy or Eczema	0.1	0.3	0.7	-0.2	-0.9	-0.5	-0.1	-0.6
Lung FEV1/FVC ratio	0.1	0.4	1.2	0.8	1.1	0.4	0.1	0.4
Chronotype (morning person)	0.1	0.3	0.7	-0.3	-0.8	-0.4	-0.5	-0.4
Hair Pigment	0.1	2.0	2.6	-1.6	-1.6	-1.5	-0.7	-1.6
Medication for hormone replacement therapy	0.1	0.1	0.4	0.1	0.4	0.2	0.7	0.2
Diabetes (mother)	0.1	0.1	0.2	-0.4	-0.4	-0.0	-0.3	-0.0
Pack years adult smoking proportion	0.1	0.2	0.2	0.3	0.2	0.4	0.5	0.5
Fed-up feelings	0.1	0.2	0.4	0.5	-0.4	0.6	0.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.2	-0.5	-0.3	0.0	-0.4
Stomach or abdominal pain in last month	0.1	0.2	0.7	0.2	-0.2	0.2	-0.9	0.2
Nervous feelings	0.1	0.2	1.2	0.0	-0.1	0.0	1.1	0.1
Qualifications: None of the above	0.1	0.1	0.2	0.2	0.3	0.4	-0.5	0.4
Medication: Simvastatin	0.1	0.2	0.5	-0.3	-0.4	-0.4	-0.7	-0.4
Fluid intelligence score	0.1	0.2	0.6	0.2	-0.8	-0.5	-0.1	-0.4
Worrier / anxious feelings	0.1	0.1	0.3	0.5	-0.5	0.1	0.0	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.6	0.2	0.8	0.1	0.2	0.1
Loud music exposure frequency	0.1	0.1	0.2	-0.2	0.3	0.0	-0.4	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	0.4	-0.1	-0.4	-0.5	-0.4
Gout (self-reported)	0.1	0.1	0.2	0.3	0.5	-0.0	0.1	-0.1
Birth weight	0.1	0.1	0.4	0.4	0.1	-0.1	-0.6	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.2	-0.5	0.1	-0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.6	-0.2	-0.2	0.0	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.4	0.3	-0.4	0.4	-0.4
Neck or shoulder pain in last month	0.1	0.1	0.3	0.3	-0.2	0.5	0.3	0.5
Heart disease (mother)	0.1	0.2	0.5	-0.2	0.5	-0.2	0.7	-0.1
Alcohol intake frequency.	0.1	0.3	0.6	-0.2	-0.4	-0.6	-0.7	-0.6
Number of full sisters	0.1	0.1	0.5	-0.2	0.1	-0.2	0.7	-0.2
Average weekly red wine intake	0.1	0.2	0.4	-0.2	-0.7	-0.2	-0.6	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.3	0.2	0.3	-0.4	0.4
Mood swings	0.1	0.1	0.2	0.1	-0.4	0.3	0.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.5	-0.3
Osteoporosis (self-reported)	0.1	0.2	0.3	0.1	-0.5	-0.5	0.0	-0.6
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.1	0.2	-0.1	-0.5	-0.1
Medication: Aspirin	0.1	0.1	0.4	0.0	0.4	0.1	0.6	0.1
Medication: Gliclazide	0.1	0.1	0.5	0.0	0.7	-0.0	0.4	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.3	0.8	-0.2	-0.1	-0.2
Miserableness	0.1	0.1	0.4	0.1	-0.6	0.2	0.1	0.2
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.4	0.1	-0.5	-0.2	-0.5
Medication: Atorvastatin	0.1	0.1	0.3	0.5	0.0	0.2	-0.4	0.2
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.1	-0.1	0.4	0.4	0.4
Unable to work because of sickness or disability	0.1	0.1	0.6	-0.1	0.1	0.1	-0.8	0.0
Cholesterol lowering medication	0.1	0.2	0.5	-0.7	-0.0	-0.4	-0.2	-0.4
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.5	0.5	-0.2	-0.5	-0.3
Pack years of smoking	0.1	0.2	0.2	0.4	0.2	0.4	0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.4	0.6	0.2	-0.1	0.2	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.1	0.1	0.2	0.4	-0.0	-0.3	0.2
Blood White Count	0.0	0.2	0.3	0.2	0.4	0.3	0.6	0.4
Lung FVC	0.0	0.1	0.2	0.3	-0.1	-0.3	-0.1	-0.4
Tanning	0.0	0.1	0.6	-0.0	-0.0	-0.1	-0.8	-0.1
Hand grip strength (right)	0.0	0.0	0.1	0.2	-0.1	-0.0	-0.4	-0.0
Age when periods started (menarche)	0.0	0.1	0.3	0.2	0.2	-0.1	0.5	-0.1
Past tobacco smoking	0.0	0.0	0.1	0.0	-0.1	-0.0	-0.3	0.0
Allergy	0.0	0.0	0.1	0.1	0.3	0.2	0.2	0.3
Falls in the last year	0.0	0.0	0.0	-0.2	-0.1	0.0	0.1	-0.0
Number of live births	0.0	0.0	0.1	0.2	0.0	-0.0	-0.3	-0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.1	-0.1
Medication: Lansoprazole	0.0	0.0	0.1	-0.2	-0.4	0.2	-0.1	0.2
Illnesses of mother	0.0	0.1	0.2	0.4	-0.1	0.1	0.2	0.1
Medication: Paracetamol	0.0	0.0	0.2	-0.0	0.4	-0.1	0.1	-0.1
Breast cancer (self-reported)	0.0	0.1	0.2	0.4	-0.2	0.0	-0.2	0.1
Ever taken oral contraceptive pill	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.2	-0.3
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.2	0.1	0.0	-0.1	-0.0
Risk taking	0.0	0.1	0.2	-0.0	0.3	-0.1	-0.4	-0.1
Alcohol drinker status: Previous	0.0	0.0	0.1	-0.0	0.3	-0.2	-0.0	-0.2

Hub : Genes

C14orf119

Models

Trait associations