Hub : Genes

C15orf41

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1312	0.0497	0.00530	0.000	NA	0.000	NA	0.000	3.2e-01	NA	3.4e-01	NA	2.8e-01
2	METSIM	Adipose	0.0823	0.0272	0.00015	0.049	0.026	0.033	0.034	0.038	6.1e-08	6.4e-05	7.9e-06	6e-06	2.1e-06
3	TCGA	Brain Lower Grade Glioma	0.0775	0.0292	0.00034	0.045	0.020	0.026	NA	0.040	7.6e-06	2.1e-03	4.8e-04	NA	2.1e-05
4	TCGA	Thyroid Carcinoma	0.0610	0.0250	0.00039	0.058	0.018	0.035	NA	0.041	2.6e-06	5.8e-03	2.1e-04	NA	6.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.1	0.1	-0.4	0.4	0.3	0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	0.8	0.7	0.9	0.5	0.6
Depressed Affect (Nagel 2018)	2.5	5.3	7.7	-0.8	2.6	2.8	2.5
Depression (Nagel 2018)	2.8	4.2	6.6	0.2	2.3	2.6	2.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.5	-1.6	-0.2	-0.0	-0.5
Neuroticism (Nagel 2018)	0.8	1.8	2.6	-0.5	1.6	1.6	1.4
Schizophrenia (2018)	0.4	0.8	1.8	1.3	0.8	0.4	0.7
Schizophrenia vs Biploar Disorder	0.4	0.6	2.2	1.5	-0.1	-0.1	-0.2
Worry (Nagel 2018)	0.9	1.8	2.9	-0.4	1.7	1.4	1.5
Alzheimer’s Disease (in mother)	0.3	0.3	1.2	-1.1	-0.3	-0.0	-0.1
Alzheimer’s Disease (in father)	0.9	0.9	2.0	1.4	0.9	0.4	0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	0.1	1.1	0.6	0.8
Crohns Disease (2017)	0.6	1.3	2.3	0.5	-1.0	-1.4	-1.5
Irritable Bowel Disease (IBD)	0.2	0.5	0.6	0.4	-0.7	-0.8	-0.8
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.0	0.0	0.1	0.3
Major Depression (MDD)	0.7	0.8	1.3	-0.9	-1.0	-0.5	-1.1
Reaction Time	0.9	1.7	2.3	-1.3	1.5	1.1	1.3
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.4	0.2	0.4	-0.0
Breast Cancer	0.1	0.2	0.6	-0.8	-0.3	-0.2	-0.3
Ovarian Cancer	1.2	1.7	2.4	0.7	-1.4	-1.3	-1.6
Prostate Cancer	0.4	0.5	0.7	-0.5	-0.8	-0.8	-0.8
Age at First Birth	0.1	0.2	0.4	-0.3	-0.1	-0.5	-0.6
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.0	0.3	0.2	0.3
Body Mass Index (BMI) (2010)	2.1	2.8	4.4	1.1	1.7	2.1	1.8
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.5	-0.4	-0.3	-0.1
Crohns Disease (2012)	0.3	0.4	0.6	-0.4	-0.5	-0.8	-0.8
Mean Putamen Volume	0.5	0.6	1.0	0.6	-0.6	-1.0	-0.7
Fasting Glucose	0.7	0.8	1.2	0.1	-1.0	-1.0	-1.1
HbA1C	1.0	1.1	1.6	-0.2	-1.1	-1.1	-1.3
HDL Cholesterol	1.4	2.3	3.6	1.5	-1.9	-1.4	-1.2
LDL Cholesterol	0.7	1.1	1.9	0.4	1.4	1.3	0.9
Lupus	1.2	1.8	2.9	-0.7	1.7	1.2	1.6
Neuroticism (2016)	0.8	1.1	1.5	-0.8	1.2	1.1	1.1
Primary Biliary Cirrhosis	0.3	0.4	0.6	0.7	-0.8	-0.2	-0.7
Rheumatoid Arthritis	0.3	0.4	0.7	-0.5	-0.4	-0.6	-0.9
Schizophrenia (2014)	0.3	0.6	2.1	1.5	0.3	-0.2	0.1
Triglycerides	0.2	0.3	0.9	-0.9	0.1	-0.2	-0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.2	0.4	0.0	0.0	-0.1
Ulcerative Colitis	1.2	1.7	4.9	-2.2	-0.9	-0.8	-0.7
Blood Eosinophil Count	0.0	0.2	0.6	-0.0	0.8	0.3	0.5
Blood Platelet Count	0.0	0.3	1.0	-1.0	-0.0	-0.3	0.3
Blood Red Count	2.4	23.6	32.6	-1.4	-5.6	-5.4	-5.7
Blood White Count	0.9	6.6	7.1	2.4	2.6	2.6	2.7
Heel T-Score	0.1	0.6	1.3	0.6	0.4	1.1	0.8
BMI	1.7	9.9	14.4	0.9	3.3	3.7	3.8
Height	0.3	5.0	9.3	-3.0	-1.7	-1.9	-2.0
Waist Hip Ratio (WHR)	0.2	0.9	1.5	-0.2	-1.1	-1.2	-1.0
Systolic Blood Pressure	0.3	1.7	6.6	2.6	-0.1	0.2	0.1
Smoking Status	0.5	1.3	2.0	-1.4	1.1	1.0	0.8
Allergy or Eczema	0.3	0.8	1.5	-0.4	1.2	0.8	0.9
Cardiovascular Disease	0.6	1.9	3.4	-0.0	1.4	1.6	1.8
Hypothyroidism (self reported)	0.5	1.1	1.9	0.3	1.0	1.1	1.4
Respiratory disease	0.3	0.6	2.2	-1.5	-0.1	-0.2	-0.3
Type 2 Diabetes (T2D) (2018)	1.3	2.5	3.5	-0.7	1.9	1.8	1.7
Lung FEV1/FVC ratio	0.1	0.3	0.5	-0.7	-0.6	-0.1	-0.5
Lung FVC	0.1	0.6	1.0	1.0	-0.7	-0.9	-0.4
Neuroticism	1.1	2.7	3.8	-0.2	2.0	1.9	1.9
Chronotype (morning person)	1.4	3.3	4.9	-0.2	2.2	2.0	2.1
Hair Pigment	0.0	0.2	0.4	0.3	0.6	-0.2	0.7
Tanning	0.1	0.6	1.2	0.4	0.8	1.1	0.7
Hand grip strength (left)	1.1	2.9	4.7	-0.5	-2.2	-1.7	-2.0
Number of treatments/medications taken	4.4	7.8	11.6	0.2	3.1	3.1	3.4
Average weekly spirits intake	1.5	1.9	2.5	0.7	1.6	1.5	1.5
Sensitivity / hurt feelings	0.4	0.7	1.8	-1.4	-0.5	-0.8	-0.5
Frequency of depressed mood in last 2 weeks	1.6	2.2	3.0	-1.1	1.7	1.5	1.5
Hearing difficulty/problems: Yes	1.5	2.4	3.9	-0.1	1.6	2.0	1.7
Relative age of first facial hair	2.3	4.7	7.5	-0.9	-1.8	-2.7	-2.7
Other serious medical condition/disability diagnosed by doctor	4.2	5.4	9.0	-0.1	2.5	2.5	3.0
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.3	-0.6	-0.5	-0.4	0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.3	0.2	-0.1	0.3
Systolic blood pressure, automated reading	0.7	2.2	8.1	2.9	-0.5	-0.1	-0.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.0	-0.9	1.0	0.8	1.0
Angina	0.5	0.6	0.8	-0.7	0.9	0.8	0.8
Medication for hormone replacement therapy	2.7	3.0	4.3	-0.4	1.9	2.0	2.1
Vitamin and mineral supplements	1.2	1.6	2.3	1.0	-1.1	-1.5	-1.3
Supplements: Zinc	2.2	2.4	3.7	0.3	1.6	1.9	1.7
Medication: Co-codamol	0.6	0.8	1.6	-0.2	0.7	1.3	0.9
Medication: Metformin	1.0	1.4	1.8	-0.6	1.3	1.3	1.3
Diabetes (father)	0.8	0.9	1.8	-1.4	-0.8	-0.9	-0.7
Diabetes (mother)	0.2	0.3	0.4	-0.7	-0.5	-0.4	-0.4
Severe depression (siblings)	0.0	0.1	0.1	-0.2	0.4	0.2	0.0
Pack years adult smoking proportion	1.5	2.3	3.7	-0.1	1.6	1.9	1.7
Impedance of leg (right)	0.5	2.5	3.8	0.3	-1.8	-1.9	-1.7
Leg fat-free mass (left)	0.3	1.5	1.7	-1.3	1.1	1.2	1.2
Trunk fat percentage	0.7	2.9	3.5	1.4	1.8	1.8	1.9
Hand grip strength (right)	3.4	9.3	13.8	-0.9	-3.7	-3.2	-3.5
Townsend deprivation index at recruitment	3.2	4.5	6.8	-1.5	2.6	2.0	2.3
Current tobacco smoking	0.0	0.1	0.1	-0.3	0.3	0.3	0.0
Average weekly fortified wine intake	0.1	0.1	0.2	0.2	0.5	-0.0	0.4
Maternal smoking around birth	0.6	0.8	1.2	0.7	1.0	1.1	0.8
Fed-up feelings	0.7	1.2	1.6	-1.0	1.1	1.3	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	5.5	0.2	2.0	2.4	2.1
Relative age voice broke	0.7	1.1	1.5	-1.2	-1.1	-1.0	-0.9
Taking other prescription medications	3.3	5.0	7.6	0.8	2.3	2.6	2.8
Age when periods started (menarche)	0.3	0.7	2.5	1.6	0.0	-0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.8	-1.3	-0.6	-0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.4	0.7	0.8	1.2	1.0
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	4.0	1.4	1.7	2.0	1.5
Qualifications: CSEs or equivalent	0.1	0.1	0.5	-0.7	0.0	-0.1	-0.1
Serious illness, injury or assault to yourself	1.2	1.4	5.1	-2.3	0.5	0.3	0.6
High blood pressure	0.4	1.2	1.7	1.2	0.8	1.0	1.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	0.0	0.7	0.3	0.4
Multivitamins +/- minerals	2.0	2.5	6.3	-2.5	0.9	1.3	1.2
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.1	-0.6	-0.6	-0.4
Supplements: Glucosamine	1.3	1.7	3.1	0.5	1.4	1.8	1.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.5	0.7	0.4	-0.0	0.0
Medication: Atenolol	0.9	1.1	4.0	2.0	0.2	0.4	0.7
Medication: Levothyroxine sodium	1.4	2.4	3.5	0.2	1.9	1.6	1.9
Sitting height	0.8	5.9	14.4	-3.8	-1.5	-1.8	-1.9
Chronic bronchitis/emphysema (father)	2.4	2.8	3.5	-1.7	1.9	1.1	1.8
High blood pressure (mother)	0.0	0.1	0.1	0.3	0.4	-0.1	-0.1
Body mass index (BMI)	0.9	3.6	5.2	1.3	1.9	2.3	2.0
Impedance of leg (left)	0.7	3.2	4.9	-0.3	-2.0	-2.2	-1.9
Leg predicted mass (left)	0.3	1.4	1.7	-1.3	1.1	1.2	1.2
Trunk fat mass	0.8	3.6	4.7	0.9	2.0	2.1	2.2
Waist circumference	0.3	0.9	1.4	-0.1	1.0	1.1	1.2
Number of incorrect matches in round	1.6	2.7	3.3	1.1	1.8	1.8	1.8
Past tobacco smoking	0.5	0.9	1.6	0.8	-1.3	-0.8	-0.8
Alcohol usually taken with meals	0.7	1.2	1.4	0.9	-1.1	-1.2	-1.2
Nervous feelings	0.0	0.1	0.2	-0.4	0.0	-0.0	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.0	-0.5	0.9	0.9	1.0
Hearing difficulty/problems with background noise	0.9	1.4	2.0	-0.6	1.1	1.4	1.4
Hair/balding pattern: Pattern 2	0.5	0.6	1.4	-0.2	-1.2	-0.6	-0.9
Had menopause	0.5	0.6	1.3	-0.2	-0.6	-0.8	-1.1
Had other major operations	0.8	1.0	1.8	-0.8	0.8	1.0	1.3
Forced vital capacity (FVC)	0.5	1.9	3.7	-1.9	-1.2	-1.2	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.6	0.6	0.8	1.3	1.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.8	-0.2	0.9	0.8	1.3
Qualifications: None of the above	0.6	1.2	3.5	1.9	0.5	0.6	0.8
Financial difficulties in last 2 years	0.4	0.6	1.9	-1.4	0.3	0.1	0.6
Mouth/teeth dental problems	1.7	2.6	3.0	-1.4	-1.7	-1.7	-1.6
Heart attack	0.2	0.2	0.6	0.2	0.2	-0.1	0.8
Allergy	0.3	0.7	1.4	1.2	-1.0	-0.2	-0.6
Pain all over the body in last month	1.1	1.2	3.7	-1.9	0.7	0.2	0.7
Diabetes (self-reported)	1.5	2.3	4.2	-0.5	2.1	1.5	1.6
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	5.1	-2.3	0.3	-0.3	-0.4
Medication: Ramipril	1.2	1.6	2.9	-1.7	1.2	1.0	1.0
Medication: Simvastatin	0.9	1.3	2.2	-0.1	1.1	1.5	1.4
Fluid intelligence score	0.4	0.8	2.2	-1.5	-0.6	-0.2	-0.6
Illnesses of siblings	0.8	1.1	1.9	0.0	-1.4	-1.0	-1.1
Neuroticism score	0.5	1.0	1.3	-1.1	1.0	0.8	1.1
Weight	0.3	1.5	2.1	-0.6	1.3	1.4	1.4
Impedance of arm (right)	0.2	0.7	0.9	-0.7	-0.8	-1.0	-0.9
Arm fat percentage (right)	1.3	5.2	7.2	1.3	2.3	2.7	2.6
Trunk fat-free mass	0.2	1.1	1.6	-1.3	0.8	1.1	0.9
Hip circumference	0.4	1.6	2.4	-0.3	1.3	1.6	1.4
Time employed in main current job	1.9	2.2	3.1	-0.1	1.8	1.7	1.7
Alcohol intake versus 10 years previously	0.1	0.1	0.5	-0.7	-0.3	0.1	-0.1
Father’s age at death	0.1	0.1	0.2	-0.0	0.2	-0.3	-0.5
Worrier / anxious feelings	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.2
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	5.9	-0.8	2.4	2.0	2.1
Falls in the last year	0.1	0.1	0.2	-0.4	0.1	-0.4	0.0
Hair/balding pattern: Pattern 3	0.4	0.6	2.5	1.6	-0.2	-0.0	-0.3
Number of live births	0.6	0.9	1.6	0.6	-1.2	-0.9	-1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.9	-2.0	-1.5	-1.4	-1.3
Pulse rate	0.9	1.6	2.5	-0.7	-1.6	-1.3	-1.2
Happiness	2.7	3.3	4.7	0.1	2.2	2.0	2.1
Noisy workplace	0.0	0.0	0.1	0.2	-0.3	0.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	-1.1	0.8	0.7	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	3.0	-0.8	-1.4	-1.7	-1.4
Mouth/teeth dental problems: Dentures	0.6	1.0	1.4	0.5	1.2	1.2	1.0
Asthma	0.6	1.2	2.2	-1.5	1.2	0.8	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.7	0.5	0.2	0.6
Medication: Cholesterol lowering	1.7	2.6	3.9	-0.3	1.8	1.9	2.0
Depression (self-reported)	0.3	0.3	0.5	0.4	0.7	0.4	0.7
Medication: Lansoprazole	0.8	0.9	1.5	0.2	-1.1	-0.9	-1.2
Prospective memory result	2.2	2.7	4.2	2.1	1.5	1.6	1.4
Lung cancer (father)	2.0	2.3	3.3	-1.0	1.4	1.7	1.8
Illnesses of mother	2.2	2.7	4.6	-0.1	-2.1	-1.8	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	4.3	-1.9	-2.1	-1.6	-1.7
Pulse wave Arterial Stiffness index	0.9	1.0	1.5	-0.2	-1.2	-1.1	-1.2
Impedance of arm (left)	0.4	2.0	3.6	-0.7	-1.4	-1.9	-1.5
Arm fat mass (right)	1.0	4.1	6.0	0.7	2.1	2.4	2.3
Trunk predicted mass	0.2	0.9	1.5	-1.2	0.7	1.0	0.8
Standing height	0.4	4.4	13.2	-3.6	-1.0	-1.4	-1.2
Length of working week for main job	0.2	0.3	1.0	-1.0	-0.0	-0.1	0.2
Exposure to tobacco smoke at home	0.2	0.3	0.5	-0.7	0.3	0.6	0.4
Breastfed as a baby	3.3	4.1	6.5	-0.5	-2.5	-2.1	-2.3
Tense / ‘highly strung’	0.6	1.0	1.5	-1.2	0.9	1.0	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.9	-1.4	1.1	1.2	0.6
Hair/balding pattern: Pattern 4	0.4	1.1	3.6	-1.9	0.6	-0.2	0.5
Birth weight of first child	2.3	4.3	5.9	0.7	2.4	2.4	2.3
Peak expiratory flow (PEF)	0.3	0.7	2.6	-1.6	0.1	0.2	0.2
Pulse wave reflection index	0.1	0.1	0.2	-0.4	-0.2	-0.4	-0.4
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.2	0.5	1.5	1.2	1.4
Loud music exposure frequency	1.5	1.6	2.6	-0.7	1.4	1.2	1.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	-1.1	-0.5	-0.2	-0.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.5	1.9	0.7	0.7	1.0
Blood clot in the leg (DVT)	0.9	1.1	1.6	0.5	1.3	1.1	1.3
Medication: Paracetamol	2.7	4.5	6.4	-2.5	2.1	1.8	2.0
Headache pain in last month	0.0	0.0	0.0	-0.2	0.1	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	5.3	8.7	12.9	-1.1	-3.2	-3.3	-3.6
Glaucoma (self-reported)	0.4	0.4	0.6	-0.7	-0.5	-0.6	-0.7
Gout (self-reported)	0.2	0.3	0.9	1.0	0.1	0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.3	0.5	1.2	1.0	1.5
Medication: Amlodipine	0.6	0.9	1.8	0.1	-0.7	-1.3	-1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.5	-1.6	0.8	0.1	0.3
Birth weight	0.3	0.6	0.9	1.0	-0.9	-0.8	-0.4
Chronic bronchitis/emphysema (mother)	4.8	5.6	7.6	0.9	2.8	2.5	2.7
High blood pressure (siblings)	0.1	0.2	0.3	0.3	0.5	0.5	0.3
Forced vital capacity (FVC), Best measure	0.7	2.4	3.3	-1.8	-1.7	-1.4	-1.3
Body fat percentage	1.0	3.8	4.4	1.6	2.0	2.1	2.1
Leg fat percentage (right)	1.2	4.4	5.9	2.4	1.9	2.1	1.9
Arm fat-free mass (right)	0.2	0.8	0.9	-0.8	0.9	1.0	0.9
Exposure to tobacco smoke outside home	1.0	1.3	2.2	-0.3	1.1	1.2	1.5
Comparative body size at age 10	0.3	0.8	1.6	-0.1	0.7	1.1	1.3
Number of full brothers	0.4	0.5	0.8	-0.9	-0.8	-0.6	-0.6
Worry too long after embarrassment	0.6	1.0	1.4	-1.2	-0.8	-1.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.3	-1.8	-0.4	-0.0	-0.2
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.1	0.3	-0.0	0.1
Number of children fathered	2.1	2.4	3.6	-1.2	-1.9	-1.3	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	-0.8	-0.0	-1.1	-0.5
Age at first live birth	1.0	1.8	3.1	0.4	-1.4	-1.8	-1.5
Pulse wave peak to peak time	1.1	1.3	1.9	-0.1	1.4	1.3	1.3
Health satisfaction	2.7	3.5	4.0	-1.6	1.9	2.0	1.9
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.5	0.3	0.1	0.3
Qualifications: College or University degree	0.2	0.7	2.4	-1.5	-0.3	-0.5	-0.4
Eye problems/disorders: None of the above	0.5	0.6	1.1	-0.2	0.9	0.7	1.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.9	1.7	-0.0	-0.1	-0.2
Emphysema/chronic bronchitis	2.4	2.7	3.5	-0.9	1.9	1.8	1.8
Medication for pain relief, constipation, heartburn	3.8	6.5	9.9	0.8	-2.9	-2.7	-3.1
Neck or shoulder pain in last month	0.5	0.8	3.0	-1.7	0.3	-0.2	-0.1
Medication: Blood pressure	5.0	8.9	11.4	1.9	3.2	3.2	3.4
Angina (self-reported)	0.3	0.4	0.5	-0.4	0.7	0.6	0.7
Migraine (self-reported)	0.4	0.5	1.1	-0.0	-0.7	-0.7	-1.0
Medication: Ibuprofen	0.1	0.1	0.2	0.2	-0.4	-0.5	-0.2
Medication: Allopurinol	1.2	1.6	5.8	2.4	0.2	0.5	0.5
Medication: Omeprazole	2.6	3.2	4.5	0.4	1.9	2.1	2.1
Medication: Seretide 50 evohaler	0.8	0.9	1.3	-0.3	-1.0	-1.1	-1.1
Mean time to correctly identify matches	0.5	0.9	1.2	-0.6	1.1	1.1	1.0
Heart disease (mother)	1.4	1.7	3.5	0.8	1.2	1.9	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.0	0.1	-0.2	0.2
Whole body fat mass	1.0	4.2	5.5	1.1	2.2	2.3	2.3
Leg fat mass (right)	0.9	3.5	4.5	1.4	1.9	2.1	2.0
Arm predicted mass (right)	0.2	0.9	1.1	-0.7	1.0	1.0	1.0
Pulse rate, automated reading	0.2	0.8	1.6	-0.0	-0.9	-0.9	-1.3
Alcohol intake frequency.	1.1	2.6	3.4	-1.9	1.3	1.8	1.4
Comparative height size at age 10	0.5	3.0	10.5	-3.2	1.0	0.2	0.7
Number of full sisters	0.6	0.8	1.5	0.0	-1.0	-1.2	-0.8
Suffer from ‘nerves’	0.7	1.1	1.8	-1.3	0.8	0.9	1.0
Overall health rating	2.6	5.6	8.3	-1.6	2.9	2.1	2.7
Chest pain or discomfort	0.5	0.7	1.3	-1.2	-0.5	-0.9	-0.7
Had major operations	0.5	0.6	1.2	-0.1	1.1	0.7	0.8
Age at last live birth	1.3	2.0	3.2	-0.7	-1.3	-1.8	-1.6
Family relationship satisfaction	1.9	2.3	3.3	1.0	1.8	1.3	1.8
Leg pain on walking	0.8	1.0	1.2	-1.0	0.8	1.0	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	2.8	-1.7	1.4	1.6	1.4
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.3	1.2	0.2	-0.2	0.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.2	1.5	-0.1	0.2	-0.6
Medication: Aspirin	2.7	3.5	4.9	0.3	2.0	2.2	2.2
Supplements: Vitamin C	0.4	0.5	0.8	0.7	0.9	0.8	0.5
Knee pain experienced in last month	0.1	0.2	0.5	-0.7	0.3	0.1	0.4
Hypertension (Self-reported)	0.7	2.0	2.5	1.5	1.1	1.3	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	0.3	-0.3	-0.1	-0.6
Illnesses of father: Heart disease	0.2	0.3	1.3	-1.2	0.1	0.2	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.7	0.5	0.2	0.2
Smoking status: Previous	0.7	1.0	1.7	-0.6	1.3	0.9	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	13.0	-3.6	-0.7	-0.7	-0.8
Whole body fat-free mass	0.2	1.3	2.0	-1.4	1.0	1.1	1.0
Leg fat-free mass (right)	0.3	1.5	3.1	-1.8	1.0	1.1	1.0
Arm fat percentage (left)	1.2	5.0	6.3	1.6	2.2	2.5	2.5
Average weekly red wine intake	0.3	0.5	0.7	-0.8	-0.3	-0.7	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.3	-0.6	-0.5	-0.9
Mood swings	1.7	3.0	4.7	-0.5	2.0	2.2	1.8
Loneliness, isolation	2.4	3.3	4.9	-0.9	2.0	1.9	2.2
Long-standing illness, disability or infirmity	9.7	14.8	20.3	-1.2	4.5	4.2	4.5
Ever had bowel cancer screening	0.9	1.0	1.6	0.8	1.3	0.8	1.1
Diabetes diagnosed by doctor	2.1	3.4	4.8	-0.5	2.2	2.1	2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.9	-1.7	-1.1	-0.9	-0.6
Friendships satisfaction	4.5	5.6	7.7	1.1	2.7	2.8	2.5
Qualifications: nursing, teaching	1.6	2.5	3.7	0.1	1.8	1.7	1.9
Commuting to job workplace: Walk	0.3	0.3	1.2	-1.1	-0.1	-0.0	0.1
Eye problems/disorders: Cataract	0.9	1.0	1.4	0.2	-1.1	-1.2	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.1	0.7	0.7	0.4
Medication for cholesterol	0.4	0.6	1.1	0.5	-0.8	-0.7	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	0.4	-0.1	-0.1	-0.2
Back pain experienced in last month	0.4	0.5	0.9	-0.8	-0.5	-1.0	-0.6
Mineral and other dietary supplements	3.2	4.3	5.5	-1.2	-2.3	-2.3	-2.2
Breast cancer (self-reported)	1.0	1.1	1.5	0.6	1.1	1.2	1.2
Asthma (self-reported)	0.6	1.2	3.1	-1.8	1.1	0.6	0.6
Osteoporosis (self-reported)	0.2	0.2	0.7	-0.9	0.2	-0.3	-0.1
Osteoarthritis (self-reported)	2.8	3.7	5.7	-0.2	2.4	2.0	2.2
Medication: Aspirin	2.6	3.4	4.9	0.1	2.0	2.2	2.1
Medication: Gliclazide	0.3	0.3	1.3	-1.2	0.1	-0.1	0.1
Illnesses of father: None of the above (group 1)	0.4	0.4	1.6	1.3	-0.3	-0.1	-0.2
Smoking status: Current	0.0	0.1	0.1	-0.2	0.3	0.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	0.9	-0.5	-1.0	-0.7	-0.7
Whole body water mass	0.2	1.4	1.9	-1.4	1.0	1.2	1.0
Leg predicted mass (right)	0.3	1.5	3.4	-1.8	0.9	1.0	0.9
Arm fat mass (left)	0.8	3.1	4.2	1.0	1.8	2.0	2.0
Number of self-reported non-cancer illnesses	0.8	1.3	2.0	-1.3	0.9	0.9	1.4
Average weekly champagne plus white wine intake	1.3	1.8	2.6	0.6	-1.4	-1.5	-1.6
Miserableness	1.7	2.9	3.8	-2.0	1.6	1.6	1.7
Guilty feelings	0.5	0.7	1.1	0.7	-0.8	-1.1	-0.6
Wears glasses or contact lenses	1.1	1.2	1.4	1.1	1.2	1.0	1.1
Ever taken oral contraceptive pill	0.1	0.2	0.5	-0.7	-0.3	0.1	0.2
Hearing aid user	0.7	0.8	1.4	1.2	0.4	0.9	0.9
Mother’s age at death	1.1	1.3	2.3	-0.6	-1.0	-1.5	-1.3
Financial situation satisfaction	1.8	2.3	3.5	-0.6	1.6	1.7	1.9
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	-0.6	-0.7	-0.8	-0.9
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.2	0.1	0.2	0.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.1	-0.8	-0.8	-0.8	-1.1
Medication: Blood pressure	0.1	0.2	0.5	-0.7	-0.2	-0.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	-0.5	0.6	0.4	0.4
Supplements: Fish oil (including cod liver oil)	2.2	2.9	3.3	1.3	1.8	1.8	1.8
High cholesterol (Self-reported)	0.5	0.9	1.4	1.2	0.7	0.9	0.9
Medication: Bendroflumethiazide	0.6	1.0	1.6	0.8	0.8	1.2	1.0
Medication: Paracetamol	2.4	3.8	5.1	-2.3	2.0	1.6	1.9
Medication: Lisinopril	1.3	1.7	3.5	1.9	1.1	1.1	1.0
Medication: Atorvastatin	0.1	0.1	0.2	0.5	-0.5	-0.3	-0.2
Illnesses of father: High blood pressure	0.0	0.1	0.2	0.4	-0.1	-0.2	-0.1
Alcohol drinker status: Never	1.2	1.5	2.4	-0.9	1.6	1.3	1.0
Ever smoked	0.4	0.8	1.3	-0.3	1.2	0.9	0.9
Basal metabolic rate	0.3	1.5	1.7	-1.3	1.1	1.3	1.2
Leg fat percentage (left)	0.9	3.4	3.9	2.0	1.7	1.9	1.8
Arm fat-free mass (left)	0.3	1.3	1.7	-1.0	1.1	1.3	1.1
Number of operations (self-reported)	1.7	2.5	3.5	-0.0	1.9	1.7	1.8
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.2	-0.2	0.6	0.5
Irritability	0.2	0.4	0.7	-0.0	0.8	0.8	0.4
Risk taking	4.1	6.0	9.0	-0.5	2.5	3.0	2.9
Ever had prostate specific antigen (PSA) test	6.2	7.1	8.0	2.8	2.7	2.6	2.5
Fractured/broken bones in last 5 years	0.7	0.9	1.3	0.7	1.1	0.8	1.1
Age started oral contraceptive pill	0.1	0.2	0.4	0.6	0.4	0.1	0.1
Diastolic blood pressure, automated reading	0.8	2.5	3.8	1.2	-1.9	-1.3	-1.7
Ever depressed for a whole week	0.4	0.5	0.8	-0.3	0.9	0.8	0.8
Unable to work because of sickness or disability	2.9	3.7	5.8	-1.0	2.3	1.7	2.4
Commuting to job workplace: Cycle	0.3	0.4	0.6	-0.2	-0.6	-0.6	-0.8
Myopia	0.8	1.1	1.4	0.7	1.1	1.2	1.1
Vascular/heart problems diagnosed by doctor	0.5	1.4	1.9	-1.3	-1.0	-1.1	-1.4
Cholesterol lowering medication	0.7	1.1	1.7	-0.1	-1.3	-1.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	2.3	2.9	3.8	0.8	1.9	2.0	1.9
Pain experienced in last month	0.3	0.4	1.4	1.2	0.0	0.5	-0.1
Supplements: Calcium	0.8	0.9	1.8	-0.6	1.4	0.9	0.7
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	0.3	0.7	1.1	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.0	-0.0	-0.3	0.5
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.2	0.6	1.4	1.2	1.5
Heart disease (siblings)	0.7	0.8	3.2	-1.8	0.3	-0.1	0.1
Alcohol drinker status: Previous	1.6	1.9	7.1	-2.7	0.4	0.2	0.3
Pack years of smoking	2.2	3.2	4.8	0.6	1.9	2.2	2.0
Impedance of whole body	0.6	2.9	5.0	-0.6	-1.7	-2.2	-1.9
Leg fat mass (left)	0.7	2.7	3.7	1.0	1.8	1.9	1.8
Arm predicted mass (left)	0.2	0.9	1.4	-0.6	0.9	1.2	0.9