TWAS hub - C15orf41

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1312	0.0497	0.00530	0.000	NA	0.000	NA	0.000	3.2e-01	NA	3.4e-01	NA	2.8e-01
2	METSIM	Adipose	0.0823	0.0272	0.00015	0.049	0.026	0.033	0.034	0.038	6.1e-08	6.4e-05	7.9e-06	6e-06	2.1e-06
3	TCGA	Brain Lower Grade Glioma	0.0775	0.0292	0.00034	0.045	0.020	0.026	NA	0.040	7.6e-06	2.1e-03	4.8e-04	NA	2.1e-05
4	TCGA	Thyroid Carcinoma	0.0610	0.0250	0.00039	0.058	0.018	0.035	NA	0.041	2.6e-06	5.8e-03	2.1e-04	NA	6.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Long-standing illness, disability or infirmity	9.7	14.8	20.3	-1.2	4.5	4.2	4.5
Ever had prostate specific antigen (PSA) test	6.2	7.1	8.0	2.8	2.7	2.6	2.5
Medication for cholesterol, blood pressure or diabetes	5.3	8.7	12.9	-1.1	-3.2	-3.3	-3.6
Medication: Blood pressure	5.0	8.9	11.4	1.9	3.2	3.2	3.4
Chronic bronchitis/emphysema (mother)	4.8	5.6	7.6	0.9	2.8	2.5	2.7
Friendships satisfaction	4.5	5.6	7.7	1.1	2.7	2.8	2.5
Number of treatments/medications taken	4.4	7.8	11.6	0.2	3.1	3.1	3.4
Other serious medical condition/disability diagnosed by doctor	4.2	5.4	9.0	-0.1	2.5	2.5	3.0
Risk taking	4.1	6.0	9.0	-0.5	2.5	3.0	2.9
Medication for pain relief, constipation, heartburn	3.8	6.5	9.9	0.8	-2.9	-2.7	-3.1
Hand grip strength (right)	3.4	9.3	13.8	-0.9	-3.7	-3.2	-3.5
Taking other prescription medications	3.3	5.0	7.6	0.8	2.3	2.6	2.8
Breastfed as a baby	3.3	4.1	6.5	-0.5	-2.5	-2.1	-2.3
Townsend deprivation index at recruitment	3.2	4.5	6.8	-1.5	2.6	2.0	2.3
Mineral and other dietary supplements	3.2	4.3	5.5	-1.2	-2.3	-2.3	-2.2
Unable to work because of sickness or disability	2.9	3.7	5.8	-1.0	2.3	1.7	2.4
Depression (Nagel 2018)	2.8	4.2	6.6	0.2	2.3	2.6	2.1
Osteoarthritis (self-reported)	2.8	3.7	5.7	-0.2	2.4	2.0	2.2
Medication for hormone replacement therapy	2.7	3.0	4.3	-0.4	1.9	2.0	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	5.5	0.2	2.0	2.4	2.1
Happiness	2.7	3.3	4.7	0.1	2.2	2.0	2.1
Medication: Paracetamol	2.7	4.5	6.4	-2.5	2.1	1.8	2.0
Health satisfaction	2.7	3.5	4.0	-1.6	1.9	2.0	1.9
Medication: Aspirin	2.7	3.5	4.9	0.3	2.0	2.2	2.2
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	4.0	1.4	1.7	2.0	1.5
Medication: Omeprazole	2.6	3.2	4.5	0.4	1.9	2.1	2.1
Overall health rating	2.6	5.6	8.3	-1.6	2.9	2.1	2.7
Medication: Aspirin	2.6	3.4	4.9	0.1	2.0	2.2	2.1
Depressed Affect (Nagel 2018)	2.5	5.3	7.7	-0.8	2.6	2.8	2.5
Blood Red Count	2.4	23.6	32.6	-1.4	-5.6	-5.4	-5.7
Chronic bronchitis/emphysema (father)	2.4	2.8	3.5	-1.7	1.9	1.1	1.8
Emphysema/chronic bronchitis	2.4	2.7	3.5	-0.9	1.9	1.8	1.8
Loneliness, isolation	2.4	3.3	4.9	-0.9	2.0	1.9	2.2
Medication: Paracetamol	2.4	3.8	5.1	-2.3	2.0	1.6	1.9
Relative age of first facial hair	2.3	4.7	7.5	-0.9	-1.8	-2.7	-2.7
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	5.9	-0.8	2.4	2.0	2.1
Birth weight of first child	2.3	4.3	5.9	0.7	2.4	2.4	2.3
Medication: Omeprazole (e.g. Zanprol)	2.3	2.9	3.8	0.8	1.9	2.0	1.9
Supplements: Zinc	2.2	2.4	3.7	0.3	1.6	1.9	1.7
Prospective memory result	2.2	2.7	4.2	2.1	1.5	1.6	1.4
Illnesses of mother	2.2	2.7	4.6	-0.1	-2.1	-1.8	-1.8
Supplements: Fish oil (including cod liver oil)	2.2	2.9	3.3	1.3	1.8	1.8	1.8
Pack years of smoking	2.2	3.2	4.8	0.6	1.9	2.2	2.0
Body Mass Index (BMI) (2010)	2.1	2.8	4.4	1.1	1.7	2.1	1.8
Number of children fathered	2.1	2.4	3.6	-1.2	-1.9	-1.3	-1.6
Diabetes diagnosed by doctor	2.1	3.4	4.8	-0.5	2.2	2.1	2.0
Multivitamins +/- minerals	2.0	2.5	6.3	-2.5	0.9	1.3	1.2
Lung cancer (father)	2.0	2.3	3.3	-1.0	1.4	1.7	1.8
Time employed in main current job	1.9	2.2	3.1	-0.1	1.8	1.7	1.7
Family relationship satisfaction	1.9	2.3	3.3	1.0	1.8	1.3	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	2.8	-1.7	1.4	1.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	13.0	-3.6	-0.7	-0.7	-0.8
Financial situation satisfaction	1.8	2.3	3.5	-0.6	1.6	1.7	1.9
BMI	1.7	9.9	14.4	0.9	3.3	3.7	3.8
Mouth/teeth dental problems	1.7	2.6	3.0	-1.4	-1.7	-1.7	-1.6
Medication: Cholesterol lowering	1.7	2.6	3.9	-0.3	1.8	1.9	2.0
Mood swings	1.7	3.0	4.7	-0.5	2.0	2.2	1.8
Miserableness	1.7	2.9	3.8	-2.0	1.6	1.6	1.7
Number of operations (self-reported)	1.7	2.5	3.5	-0.0	1.9	1.7	1.8
Frequency of depressed mood in last 2 weeks	1.6	2.2	3.0	-1.1	1.7	1.5	1.5
Number of incorrect matches in round	1.6	2.7	3.3	1.1	1.8	1.8	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	3.0	-0.8	-1.4	-1.7	-1.4
Qualifications: nursing, teaching	1.6	2.5	3.7	0.1	1.8	1.7	1.9
Alcohol drinker status: Previous	1.6	1.9	7.1	-2.7	0.4	0.2	0.3
Average weekly spirits intake	1.5	1.9	2.5	0.7	1.6	1.5	1.5
Hearing difficulty/problems: Yes	1.5	2.4	3.9	-0.1	1.6	2.0	1.7
Pack years adult smoking proportion	1.5	2.3	3.7	-0.1	1.6	1.9	1.7
Diabetes (self-reported)	1.5	2.3	4.2	-0.5	2.1	1.5	1.6
Loud music exposure frequency	1.5	1.6	2.6	-0.7	1.4	1.2	1.6
HDL Cholesterol	1.4	2.3	3.6	1.5	-1.9	-1.4	-1.2
Chronotype (morning person)	1.4	3.3	4.9	-0.2	2.2	2.0	2.1
Medication: Levothyroxine sodium	1.4	2.4	3.5	0.2	1.9	1.6	1.9
Heart disease (mother)	1.4	1.7	3.5	0.8	1.2	1.9	1.0
Type 2 Diabetes (T2D) (2018)	1.3	2.5	3.5	-0.7	1.9	1.8	1.7
Supplements: Glucosamine	1.3	1.7	3.1	0.5	1.4	1.8	1.3
Arm fat percentage (right)	1.3	5.2	7.2	1.3	2.3	2.7	2.6
Age at last live birth	1.3	2.0	3.2	-0.7	-1.3	-1.8	-1.6
Average weekly champagne plus white wine intake	1.3	1.8	2.6	0.6	-1.4	-1.5	-1.6
Medication: Lisinopril	1.3	1.7	3.5	1.9	1.1	1.1	1.0
Ovarian Cancer	1.2	1.7	2.4	0.7	-1.4	-1.3	-1.6
Lupus	1.2	1.8	2.9	-0.7	1.7	1.2	1.6
Ulcerative Colitis	1.2	1.7	4.9	-2.2	-0.9	-0.8	-0.7
Vitamin and mineral supplements	1.2	1.6	2.3	1.0	-1.1	-1.5	-1.3
Serious illness, injury or assault to yourself	1.2	1.4	5.1	-2.3	0.5	0.3	0.6
Medication: Ramipril	1.2	1.6	2.9	-1.7	1.2	1.0	1.0
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.2	0.5	1.5	1.2	1.4
Leg fat percentage (right)	1.2	4.4	5.9	2.4	1.9	2.1	1.9
Medication: Allopurinol	1.2	1.6	5.8	2.4	0.2	0.5	0.5
Arm fat percentage (left)	1.2	5.0	6.3	1.6	2.2	2.5	2.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.9	-1.7	-1.1	-0.9	-0.6
Alcohol drinker status: Never	1.2	1.5	2.4	-0.9	1.6	1.3	1.0
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.2	0.6	1.4	1.2	1.5
Neuroticism	1.1	2.7	3.8	-0.2	2.0	1.9	1.9
Hand grip strength (left)	1.1	2.9	4.7	-0.5	-2.2	-1.7	-2.0
Pain all over the body in last month	1.1	1.2	3.7	-1.9	0.7	0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	4.3	-1.9	-2.1	-1.6	-1.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.5	1.9	0.7	0.7	1.0
Pulse wave peak to peak time	1.1	1.3	1.9	-0.1	1.4	1.3	1.3
Alcohol intake frequency.	1.1	2.6	3.4	-1.9	1.3	1.8	1.4
Wears glasses or contact lenses	1.1	1.2	1.4	1.1	1.2	1.0	1.1
Mother’s age at death	1.1	1.3	2.3	-0.6	-1.0	-1.5	-1.3
HbA1C	1.0	1.1	1.6	-0.2	-1.1	-1.1	-1.3
Medication: Metformin	1.0	1.4	1.8	-0.6	1.3	1.3	1.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	5.1	-2.3	0.3	-0.3	-0.4
Arm fat mass (right)	1.0	4.1	6.0	0.7	2.1	2.4	2.3
Body fat percentage	1.0	3.8	4.4	1.6	2.0	2.1	2.1
Exposure to tobacco smoke outside home	1.0	1.3	2.2	-0.3	1.1	1.2	1.5
Age at first live birth	1.0	1.8	3.1	0.4	-1.4	-1.8	-1.5
Whole body fat mass	1.0	4.2	5.5	1.1	2.2	2.3	2.3
Breast cancer (self-reported)	1.0	1.1	1.5	0.6	1.1	1.2	1.2
Worry (Nagel 2018)	0.9	1.8	2.9	-0.4	1.7	1.4	1.5
Alzheimer’s Disease (in father)	0.9	0.9	2.0	1.4	0.9	0.4	0.9
Reaction Time	0.9	1.7	2.3	-1.3	1.5	1.1	1.3
Blood White Count	0.9	6.6	7.1	2.4	2.6	2.6	2.7
Medication: Atenolol	0.9	1.1	4.0	2.0	0.2	0.4	0.7
Body mass index (BMI)	0.9	3.6	5.2	1.3	1.9	2.3	2.0
Hearing difficulty/problems with background noise	0.9	1.4	2.0	-0.6	1.1	1.4	1.4
Medication: Simvastatin	0.9	1.3	2.2	-0.1	1.1	1.5	1.4
Pulse rate	0.9	1.6	2.5	-0.7	-1.6	-1.3	-1.2
Pulse wave Arterial Stiffness index	0.9	1.0	1.5	-0.2	-1.2	-1.1	-1.2
Blood clot in the leg (DVT)	0.9	1.1	1.6	0.5	1.3	1.1	1.3
Leg fat mass (right)	0.9	3.5	4.5	1.4	1.9	2.1	2.0
Ever had bowel cancer screening	0.9	1.0	1.6	0.8	1.3	0.8	1.1
Eye problems/disorders: Cataract	0.9	1.0	1.4	0.2	-1.1	-1.2	-1.2
Leg fat percentage (left)	0.9	3.4	3.9	2.0	1.7	1.9	1.8
Neuroticism (Nagel 2018)	0.8	1.8	2.6	-0.5	1.6	1.6	1.4
Neuroticism (2016)	0.8	1.1	1.5	-0.8	1.2	1.1	1.1
Diabetes (father)	0.8	0.9	1.8	-1.4	-0.8	-0.9	-0.7
Sitting height	0.8	5.9	14.4	-3.8	-1.5	-1.8	-1.9
Trunk fat mass	0.8	3.6	4.7	0.9	2.0	2.1	2.2
Had other major operations	0.8	1.0	1.8	-0.8	0.8	1.0	1.3
Illnesses of siblings	0.8	1.1	1.9	0.0	-1.4	-1.0	-1.1
Medication: Lansoprazole	0.8	0.9	1.5	0.2	-1.1	-0.9	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	1.9	-1.4	1.1	1.2	0.6
Medication: Seretide 50 evohaler	0.8	0.9	1.3	-0.3	-1.0	-1.1	-1.1
Leg pain on walking	0.8	1.0	1.2	-1.0	0.8	1.0	1.1
Arm fat mass (left)	0.8	3.1	4.2	1.0	1.8	2.0	2.0
Number of self-reported non-cancer illnesses	0.8	1.3	2.0	-1.3	0.9	0.9	1.4
Diastolic blood pressure, automated reading	0.8	2.5	3.8	1.2	-1.9	-1.3	-1.7
Myopia	0.8	1.1	1.4	0.7	1.1	1.2	1.1
Supplements: Calcium	0.8	0.9	1.8	-0.6	1.4	0.9	0.7
Major Depression (MDD)	0.7	0.8	1.3	-0.9	-1.0	-0.5	-1.1
Fasting Glucose	0.7	0.8	1.2	0.1	-1.0	-1.0	-1.1
LDL Cholesterol	0.7	1.1	1.9	0.4	1.4	1.3	0.9
Systolic blood pressure, automated reading	0.7	2.2	8.1	2.9	-0.5	-0.1	-0.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.0	-0.9	1.0	0.8	1.0
Trunk fat percentage	0.7	2.9	3.5	1.4	1.8	1.8	1.9
Fed-up feelings	0.7	1.2	1.6	-1.0	1.1	1.3	1.1
Relative age voice broke	0.7	1.1	1.5	-1.2	-1.1	-1.0	-0.9
Impedance of leg (left)	0.7	3.2	4.9	-0.3	-2.0	-2.2	-1.9
Alcohol usually taken with meals	0.7	1.2	1.4	0.9	-1.1	-1.2	-1.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.8	-0.2	0.9	0.8	1.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.9	-2.0	-1.5	-1.4	-1.3
Forced vital capacity (FVC), Best measure	0.7	2.4	3.3	-1.8	-1.7	-1.4	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.3	-1.8	-0.4	-0.0	-0.2
Suffer from ‘nerves’	0.7	1.1	1.8	-1.3	0.8	0.9	1.0
Hypertension (Self-reported)	0.7	2.0	2.5	1.5	1.1	1.3	1.6
Smoking status: Previous	0.7	1.0	1.7	-0.6	1.3	0.9	1.0
Hearing aid user	0.7	0.8	1.4	1.2	0.4	0.9	0.9
Fractured/broken bones in last 5 years	0.7	0.9	1.3	0.7	1.1	0.8	1.1
Cholesterol lowering medication	0.7	1.1	1.7	-0.1	-1.3	-1.2	-1.0
Heart disease (siblings)	0.7	0.8	3.2	-1.8	0.3	-0.1	0.1
Leg fat mass (left)	0.7	2.7	3.7	1.0	1.8	1.9	1.8
Crohns Disease (2017)	0.6	1.3	2.3	0.5	-1.0	-1.4	-1.5
Cardiovascular Disease	0.6	1.9	3.4	-0.0	1.4	1.6	1.8
Medication: Co-codamol	0.6	0.8	1.6	-0.2	0.7	1.3	0.9
Maternal smoking around birth	0.6	0.8	1.2	0.7	1.0	1.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.8	-1.3	-0.6	-0.7	-0.4
Qualifications: None of the above	0.6	1.2	3.5	1.9	0.5	0.6	0.8
Number of live births	0.6	0.9	1.6	0.6	-1.2	-0.9	-1.0
Mouth/teeth dental problems: Dentures	0.6	1.0	1.4	0.5	1.2	1.2	1.0
Asthma	0.6	1.2	2.2	-1.5	1.2	0.8	0.8
Tense / ‘highly strung’	0.6	1.0	1.5	-1.2	0.9	1.0	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.3	0.5	1.2	1.0	1.5
Medication: Amlodipine	0.6	0.9	1.8	0.1	-0.7	-1.3	-1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.5	-1.6	0.8	0.1	0.3
Worry too long after embarrassment	0.6	1.0	1.4	-1.2	-0.8	-1.1	-0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.9	1.7	-0.0	-0.1	-0.2
Number of full sisters	0.6	0.8	1.5	0.0	-1.0	-1.2	-0.8
Asthma (self-reported)	0.6	1.2	3.1	-1.8	1.1	0.6	0.6
Eye problems/disorders: Glaucoma	0.6	0.7	1.1	-0.8	-0.8	-0.8	-1.1
Medication: Bendroflumethiazide	0.6	1.0	1.6	0.8	0.8	1.2	1.0
Impedance of whole body	0.6	2.9	5.0	-0.6	-1.7	-2.2	-1.9
Mean Putamen Volume	0.5	0.6	1.0	0.6	-0.6	-1.0	-0.7
Smoking Status	0.5	1.3	2.0	-1.4	1.1	1.0	0.8
Hypothyroidism (self reported)	0.5	1.1	1.9	0.3	1.0	1.1	1.4
Angina	0.5	0.6	0.8	-0.7	0.9	0.8	0.8
Impedance of leg (right)	0.5	2.5	3.8	0.3	-1.8	-1.9	-1.7
Past tobacco smoking	0.5	0.9	1.6	0.8	-1.3	-0.8	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.0	-0.5	0.9	0.9	1.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.4	-0.2	-1.2	-0.6	-0.9
Had menopause	0.5	0.6	1.3	-0.2	-0.6	-0.8	-1.1
Forced vital capacity (FVC)	0.5	1.9	3.7	-1.9	-1.2	-1.2	-1.0
Neuroticism score	0.5	1.0	1.3	-1.1	1.0	0.8	1.1
Eye problems/disorders: None of the above	0.5	0.6	1.1	-0.2	0.9	0.7	1.0
Neck or shoulder pain in last month	0.5	0.8	3.0	-1.7	0.3	-0.2	-0.1
Mean time to correctly identify matches	0.5	0.9	1.2	-0.6	1.1	1.1	1.0
Comparative height size at age 10	0.5	3.0	10.5	-3.2	1.0	0.2	0.7
Chest pain or discomfort	0.5	0.7	1.3	-1.2	-0.5	-0.9	-0.7
Had major operations	0.5	0.6	1.2	-0.1	1.1	0.7	0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.2	1.5	-0.1	0.2	-0.6
Guilty feelings	0.5	0.7	1.1	0.7	-0.8	-1.1	-0.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.8	-0.6	-0.7	-0.8	-0.9
High cholesterol (Self-reported)	0.5	0.9	1.4	1.2	0.7	0.9	0.9
Vascular/heart problems diagnosed by doctor	0.5	1.4	1.9	-1.3	-1.0	-1.1	-1.4
Schizophrenia (2018)	0.4	0.8	1.8	1.3	0.8	0.4	0.7
Schizophrenia vs Biploar Disorder	0.4	0.6	2.2	1.5	-0.1	-0.1	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	0.1	1.1	0.6	0.8
Prostate Cancer	0.4	0.5	0.7	-0.5	-0.8	-0.8	-0.8
Sensitivity / hurt feelings	0.4	0.7	1.8	-1.4	-0.5	-0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.4	0.7	0.8	1.2	1.0
High blood pressure	0.4	1.2	1.7	1.2	0.8	1.0	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.6	0.6	0.8	1.3	1.0
Financial difficulties in last 2 years	0.4	0.6	1.9	-1.4	0.3	0.1	0.6
Fluid intelligence score	0.4	0.8	2.2	-1.5	-0.6	-0.2	-0.6
Hip circumference	0.4	1.6	2.4	-0.3	1.3	1.6	1.4
Hair/balding pattern: Pattern 3	0.4	0.6	2.5	1.6	-0.2	-0.0	-0.3
Impedance of arm (left)	0.4	2.0	3.6	-0.7	-1.4	-1.9	-1.5
Standing height	0.4	4.4	13.2	-3.6	-1.0	-1.4	-1.2
Hair/balding pattern: Pattern 4	0.4	1.1	3.6	-1.9	0.6	-0.2	0.5
Glaucoma (self-reported)	0.4	0.4	0.6	-0.7	-0.5	-0.6	-0.7
Number of full brothers	0.4	0.5	0.8	-0.9	-0.8	-0.6	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	-0.8	-0.0	-1.1	-0.5
Migraine (self-reported)	0.4	0.5	1.1	-0.0	-0.7	-0.7	-1.0
Supplements: Vitamin C	0.4	0.5	0.8	0.7	0.9	0.8	0.5
Medication for cholesterol	0.4	0.6	1.1	0.5	-0.8	-0.7	-1.1
Back pain experienced in last month	0.4	0.5	0.9	-0.8	-0.5	-1.0	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.4	1.6	1.3	-0.3	-0.1	-0.2
Ever smoked	0.4	0.8	1.3	-0.3	1.2	0.9	0.9
Ever depressed for a whole week	0.4	0.5	0.8	-0.3	0.9	0.8	0.8
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	0.3	0.7	1.1	0.5
Alzheimer’s Disease (in mother)	0.3	0.3	1.2	-1.1	-0.3	-0.0	-0.1
Crohns Disease (2012)	0.3	0.4	0.6	-0.4	-0.5	-0.8	-0.8
Primary Biliary Cirrhosis	0.3	0.4	0.6	0.7	-0.8	-0.2	-0.7
Rheumatoid Arthritis	0.3	0.4	0.7	-0.5	-0.4	-0.6	-0.9
Schizophrenia (2014)	0.3	0.6	2.1	1.5	0.3	-0.2	0.1
Height	0.3	5.0	9.3	-3.0	-1.7	-1.9	-2.0
Systolic Blood Pressure	0.3	1.7	6.6	2.6	-0.1	0.2	0.1
Allergy or Eczema	0.3	0.8	1.5	-0.4	1.2	0.8	0.9
Respiratory disease	0.3	0.6	2.2	-1.5	-0.1	-0.2	-0.3
Leg fat-free mass (left)	0.3	1.5	1.7	-1.3	1.1	1.2	1.2
Age when periods started (menarche)	0.3	0.7	2.5	1.6	0.0	-0.2	-0.2
Leg predicted mass (left)	0.3	1.4	1.7	-1.3	1.1	1.2	1.2
Waist circumference	0.3	0.9	1.4	-0.1	1.0	1.1	1.2
Allergy	0.3	0.7	1.4	1.2	-1.0	-0.2	-0.6
Weight	0.3	1.5	2.1	-0.6	1.3	1.4	1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	-1.1	0.8	0.7	0.6
Depression (self-reported)	0.3	0.3	0.5	0.4	0.7	0.4	0.7
Peak expiratory flow (PEF)	0.3	0.7	2.6	-1.6	0.1	0.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	-1.1	-0.5	-0.2	-0.7
Birth weight	0.3	0.6	0.9	1.0	-0.9	-0.8	-0.4
Comparative body size at age 10	0.3	0.8	1.6	-0.1	0.7	1.1	1.3
Angina (self-reported)	0.3	0.4	0.5	-0.4	0.7	0.6	0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.3	1.2	0.2	-0.2	0.0
Leg fat-free mass (right)	0.3	1.5	3.1	-1.8	1.0	1.1	1.0
Average weekly red wine intake	0.3	0.5	0.7	-0.8	-0.3	-0.7	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	0.3	-0.6	-0.5	-0.9
Commuting to job workplace: Walk	0.3	0.3	1.2	-1.1	-0.1	-0.0	0.1
Medication: Gliclazide	0.3	0.3	1.3	-1.2	0.1	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	0.9	-0.5	-1.0	-0.7	-0.7
Leg predicted mass (right)	0.3	1.5	3.4	-1.8	0.9	1.0	0.9
Basal metabolic rate	0.3	1.5	1.7	-1.3	1.1	1.3	1.2
Arm fat-free mass (left)	0.3	1.3	1.7	-1.0	1.1	1.3	1.1
Commuting to job workplace: Cycle	0.3	0.4	0.6	-0.2	-0.6	-0.6	-0.8
Pain experienced in last month	0.3	0.4	1.4	1.2	0.0	0.5	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	0.8	0.7	0.9	0.5	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.5	-1.6	-0.2	-0.0	-0.5
Irritable Bowel Disease (IBD)	0.2	0.5	0.6	0.4	-0.7	-0.8	-0.8
Triglycerides	0.2	0.3	0.9	-0.9	0.1	-0.2	-0.4
Waist Hip Ratio (WHR)	0.2	0.9	1.5	-0.2	-1.1	-1.2	-1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.3	-0.6	-0.5	-0.4	0.1
Diabetes (mother)	0.2	0.3	0.4	-0.7	-0.5	-0.4	-0.4
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.1	-0.6	-0.6	-0.4
Heart attack	0.2	0.2	0.6	0.2	0.2	-0.1	0.8
Impedance of arm (right)	0.2	0.7	0.9	-0.7	-0.8	-1.0	-0.9
Trunk fat-free mass	0.2	1.1	1.6	-1.3	0.8	1.1	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.7	0.5	0.2	0.6
Trunk predicted mass	0.2	0.9	1.5	-1.2	0.7	1.0	0.8
Length of working week for main job	0.2	0.3	1.0	-1.0	-0.0	-0.1	0.2
Exposure to tobacco smoke at home	0.2	0.3	0.5	-0.7	0.3	0.6	0.4
Gout (self-reported)	0.2	0.3	0.9	1.0	0.1	0.3	0.1
Arm fat-free mass (right)	0.2	0.8	0.9	-0.8	0.9	1.0	0.9
Qualifications: College or University degree	0.2	0.7	2.4	-1.5	-0.3	-0.5	-0.4
Arm predicted mass (right)	0.2	0.9	1.1	-0.7	1.0	1.0	1.0
Pulse rate, automated reading	0.2	0.8	1.6	-0.0	-0.9	-0.9	-1.3
Illnesses of father: Heart disease	0.2	0.3	1.3	-1.2	0.1	0.2	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.7	0.5	0.2	0.2
Whole body fat-free mass	0.2	1.3	2.0	-1.4	1.0	1.1	1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.1	0.7	0.7	0.4
Osteoporosis (self-reported)	0.2	0.2	0.7	-0.9	0.2	-0.3	-0.1
Whole body water mass	0.2	1.4	1.9	-1.4	1.0	1.2	1.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.4	-0.5	0.6	0.4	0.4
Irritability	0.2	0.4	0.7	-0.0	0.8	0.8	0.4
Arm predicted mass (left)	0.2	0.9	1.4	-0.6	0.9	1.2	0.9
Bipolar Disorder (2018)	0.1	0.1	0.1	-0.4	0.4	0.3	0.1
Breast Cancer	0.1	0.2	0.6	-0.8	-0.3	-0.2	-0.3
Age at First Birth	0.1	0.2	0.4	-0.3	-0.1	-0.5	-0.6
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.0	0.3	0.2	0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.5	-0.4	-0.3	-0.1
Heel T-Score	0.1	0.6	1.3	0.6	0.4	1.1	0.8
Lung FEV1/FVC ratio	0.1	0.3	0.5	-0.7	-0.6	-0.1	-0.5
Lung FVC	0.1	0.6	1.0	1.0	-0.7	-0.9	-0.4
Tanning	0.1	0.6	1.2	0.4	0.8	1.1	0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	0.3	0.2	-0.1	0.3
Average weekly fortified wine intake	0.1	0.1	0.2	0.2	0.5	-0.0	0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.5	-0.7	0.0	-0.1	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	0.0	0.7	0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.5	0.7	0.4	-0.0	0.0
Alcohol intake versus 10 years previously	0.1	0.1	0.5	-0.7	-0.3	0.1	-0.1
Father’s age at death	0.1	0.1	0.2	-0.0	0.2	-0.3	-0.5
Worrier / anxious feelings	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.2
Falls in the last year	0.1	0.1	0.2	-0.4	0.1	-0.4	0.0
Pulse wave reflection index	0.1	0.1	0.2	-0.4	-0.2	-0.4	-0.4
High blood pressure (siblings)	0.1	0.2	0.3	0.3	0.5	0.5	0.3
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.5	0.3	0.1	0.3
Medication: Ibuprofen	0.1	0.1	0.2	0.2	-0.4	-0.5	-0.2
Knee pain experienced in last month	0.1	0.2	0.5	-0.7	0.3	0.1	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	0.3	-0.3	-0.1	-0.6
Ever taken oral contraceptive pill	0.1	0.2	0.5	-0.7	-0.3	0.1	0.2
Medication: Blood pressure	0.1	0.2	0.5	-0.7	-0.2	-0.4	-0.1
Medication: Atorvastatin	0.1	0.1	0.2	0.5	-0.5	-0.3	-0.2
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.2	-0.2	0.6	0.5
Age started oral contraceptive pill	0.1	0.2	0.4	0.6	0.4	0.1	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.0	-0.0	-0.3	0.5
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.0	0.0	0.1	0.3
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.4	0.2	0.4	-0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.2	0.4	0.0	0.0	-0.1
Blood Eosinophil Count	0.0	0.2	0.6	-0.0	0.8	0.3	0.5
Blood Platelet Count	0.0	0.3	1.0	-1.0	-0.0	-0.3	0.3
Hair Pigment	0.0	0.2	0.4	0.3	0.6	-0.2	0.7
Severe depression (siblings)	0.0	0.1	0.1	-0.2	0.4	0.2	0.0
Current tobacco smoking	0.0	0.1	0.1	-0.3	0.3	0.3	0.0
High blood pressure (mother)	0.0	0.1	0.1	0.3	0.4	-0.1	-0.1
Nervous feelings	0.0	0.1	0.2	-0.4	0.0	-0.0	0.4
Noisy workplace	0.0	0.0	0.1	0.2	-0.3	0.0	-0.1
Headache pain in last month	0.0	0.0	0.0	-0.2	0.1	-0.2	0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.1	0.3	-0.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.0	0.1	-0.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	0.4	-0.1	-0.1	-0.2
Smoking status: Current	0.0	0.1	0.1	-0.2	0.3	0.3	0.0
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.2	0.1	0.2	0.2
Illnesses of father: High blood pressure	0.0	0.1	0.2	0.4	-0.1	-0.2	-0.1

Hub : Genes

C15orf41

Models

Trait associations