Hub : Genes

C15orf41

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.1312 0.0497 0.00530 0.000 NA 0.000 NA 0.000 3.2e-01 NA 3.4e-01 NA 2.8e-01
2 METSIM Adipose 0.0823 0.0272 0.00015 0.049 0.026 0.033 0.034 0.038 6.1e-08 6.4e-05 7.9e-06 6e-06 2.1e-06
3 TCGA Brain Lower Grade Glioma 0.0775 0.0292 0.00034 0.045 0.020 0.026 NA 0.040 7.6e-06 2.1e-03 4.8e-04 NA 2.1e-05
4 TCGA Thyroid Carcinoma 0.0610 0.0250 0.00039 0.058 0.018 0.035 NA 0.041 2.6e-06 5.8e-03 2.1e-04 NA 6.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.1 0.1 -0.4 0.4 0.3 0.1
Bipolar Disorder or Schizophrenia 0.2 0.5 0.8 0.7 0.9 0.5 0.6
Depressed Affect (Nagel 2018) 2.5 5.3 7.7 -0.8 2.6 2.8 2.5
Depression (Nagel 2018) 2.8 4.2 6.6 0.2 2.3 2.6 2.1
Intelligence (Savage-Jansen 2018) 0.2 0.7 2.5 -1.6 -0.2 -0.0 -0.5
Neuroticism (Nagel 2018) 0.8 1.8 2.6 -0.5 1.6 1.6 1.4
Schizophrenia (2018) 0.4 0.8 1.8 1.3 0.8 0.4 0.7
Schizophrenia vs Biploar Disorder 0.4 0.6 2.2 1.5 -0.1 -0.1 -0.2
Worry (Nagel 2018) 0.9 1.8 2.9 -0.4 1.7 1.4 1.5
Alzheimer’s Disease (in mother) 0.3 0.3 1.2 -1.1 -0.3 -0.0 -0.1
Alzheimer’s Disease (in father) 0.9 0.9 2.0 1.4 0.9 0.4 0.9
Alzheimer’s Disease (including proxy) 0.4 0.6 1.2 0.1 1.1 0.6 0.8
Crohns Disease (2017) 0.6 1.3 2.3 0.5 -1.0 -1.4 -1.5
Irritable Bowel Disease (IBD) 0.2 0.5 0.6 0.4 -0.7 -0.8 -0.8
Ulcerative Colitis (UC) 0.0 0.0 0.1 0.0 0.0 0.1 0.3
Major Depression (MDD) 0.7 0.8 1.3 -0.9 -1.0 -0.5 -1.1
Reaction Time 0.9 1.7 2.3 -1.3 1.5 1.1 1.3
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 -0.4 0.2 0.4 -0.0
Breast Cancer 0.1 0.2 0.6 -0.8 -0.3 -0.2 -0.3
Ovarian Cancer 1.2 1.7 2.4 0.7 -1.4 -1.3 -1.6
Prostate Cancer 0.4 0.5 0.7 -0.5 -0.8 -0.8 -0.8
Age at First Birth 0.1 0.2 0.4 -0.3 -0.1 -0.5 -0.6
Bipolar Disorder (2011) 0.1 0.1 0.1 -0.0 0.3 0.2 0.3
Body Mass Index (BMI) (2010) 2.1 2.8 4.4 1.1 1.7 2.1 1.8
Coronary Artery Disease (CAD) 0.1 0.1 0.3 -0.5 -0.4 -0.3 -0.1
Crohns Disease (2012) 0.3 0.4 0.6 -0.4 -0.5 -0.8 -0.8
Mean Putamen Volume 0.5 0.6 1.0 0.6 -0.6 -1.0 -0.7
Fasting Glucose 0.7 0.8 1.2 0.1 -1.0 -1.0 -1.1
HbA1C 1.0 1.1 1.6 -0.2 -1.1 -1.1 -1.3
HDL Cholesterol 1.4 2.3 3.6 1.5 -1.9 -1.4 -1.2
LDL Cholesterol 0.7 1.1 1.9 0.4 1.4 1.3 0.9
Lupus 1.2 1.8 2.9 -0.7 1.7 1.2 1.6
Neuroticism (2016) 0.8 1.1 1.5 -0.8 1.2 1.1 1.1
Primary Biliary Cirrhosis 0.3 0.4 0.6 0.7 -0.8 -0.2 -0.7
Rheumatoid Arthritis 0.3 0.4 0.7 -0.5 -0.4 -0.6 -0.9
Schizophrenia (2014) 0.3 0.6 2.1 1.5 0.3 -0.2 0.1
Triglycerides 0.2 0.3 0.9 -0.9 0.1 -0.2 -0.4
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.2 0.4 0.0 0.0 -0.1
Ulcerative Colitis 1.2 1.7 4.9 -2.2 -0.9 -0.8 -0.7
Blood Eosinophil Count 0.0 0.2 0.6 -0.0 0.8 0.3 0.5
Blood Platelet Count 0.0 0.3 1.0 -1.0 -0.0 -0.3 0.3
Blood Red Count 2.4 23.6 32.6 -1.4 -5.6 -5.4 -5.7
Blood White Count 0.9 6.6 7.1 2.4 2.6 2.6 2.7
Heel T-Score 0.1 0.6 1.3 0.6 0.4 1.1 0.8
BMI 1.7 9.9 14.4 0.9 3.3 3.7 3.8
Height 0.3 5.0 9.3 -3.0 -1.7 -1.9 -2.0
Waist Hip Ratio (WHR) 0.2 0.9 1.5 -0.2 -1.1 -1.2 -1.0
Systolic Blood Pressure 0.3 1.7 6.6 2.6 -0.1 0.2 0.1
Smoking Status 0.5 1.3 2.0 -1.4 1.1 1.0 0.8
Allergy or Eczema 0.3 0.8 1.5 -0.4 1.2 0.8 0.9
Cardiovascular Disease 0.6 1.9 3.4 -0.0 1.4 1.6 1.8
Hypothyroidism (self reported) 0.5 1.1 1.9 0.3 1.0 1.1 1.4
Respiratory disease 0.3 0.6 2.2 -1.5 -0.1 -0.2 -0.3
Type 2 Diabetes (T2D) (2018) 1.3 2.5 3.5 -0.7 1.9 1.8 1.7
Lung FEV1/FVC ratio 0.1 0.3 0.5 -0.7 -0.6 -0.1 -0.5
Lung FVC 0.1 0.6 1.0 1.0 -0.7 -0.9 -0.4
Neuroticism 1.1 2.7 3.8 -0.2 2.0 1.9 1.9
Chronotype (morning person) 1.4 3.3 4.9 -0.2 2.2 2.0 2.1
Hair Pigment 0.0 0.2 0.4 0.3 0.6 -0.2 0.7
Tanning 0.1 0.6 1.2 0.4 0.8 1.1 0.7
Hand grip strength (left) 1.1 2.9 4.7 -0.5 -2.2 -1.7 -2.0
Number of treatments/medications taken 4.4 7.8 11.6 0.2 3.1 3.1 3.4
Average weekly spirits intake 1.5 1.9 2.5 0.7 1.6 1.5 1.5
Sensitivity / hurt feelings 0.4 0.7 1.8 -1.4 -0.5 -0.8 -0.5
Frequency of depressed mood in last 2 weeks 1.6 2.2 3.0 -1.1 1.7 1.5 1.5
Hearing difficulty/problems: Yes 1.5 2.4 3.9 -0.1 1.6 2.0 1.7
Relative age of first facial hair 2.3 4.7 7.5 -0.9 -1.8 -2.7 -2.7
Other serious medical condition/disability diagnosed by doctor 4.2 5.4 9.0 -0.1 2.5 2.5 3.0
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.3 -0.6 -0.5 -0.4 0.1
Ever had hysterectomy (womb removed) 0.1 0.1 0.1 0.3 0.2 -0.1 0.3
Systolic blood pressure, automated reading 0.7 2.2 8.1 2.9 -0.5 -0.1 -0.5
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.0 -0.9 1.0 0.8 1.0
Angina 0.5 0.6 0.8 -0.7 0.9 0.8 0.8
Medication for hormone replacement therapy 2.7 3.0 4.3 -0.4 1.9 2.0 2.1
Vitamin and mineral supplements 1.2 1.6 2.3 1.0 -1.1 -1.5 -1.3
Supplements: Zinc 2.2 2.4 3.7 0.3 1.6 1.9 1.7
Medication: Co-codamol 0.6 0.8 1.6 -0.2 0.7 1.3 0.9
Medication: Metformin 1.0 1.4 1.8 -0.6 1.3 1.3 1.3
Diabetes (father) 0.8 0.9 1.8 -1.4 -0.8 -0.9 -0.7
Diabetes (mother) 0.2 0.3 0.4 -0.7 -0.5 -0.4 -0.4
Severe depression (siblings) 0.0 0.1 0.1 -0.2 0.4 0.2 0.0
Pack years adult smoking proportion 1.5 2.3 3.7 -0.1 1.6 1.9 1.7
Impedance of leg (right) 0.5 2.5 3.8 0.3 -1.8 -1.9 -1.7
Leg fat-free mass (left) 0.3 1.5 1.7 -1.3 1.1 1.2 1.2
Trunk fat percentage 0.7 2.9 3.5 1.4 1.8 1.8 1.9
Hand grip strength (right) 3.4 9.3 13.8 -0.9 -3.7 -3.2 -3.5
Townsend deprivation index at recruitment 3.2 4.5 6.8 -1.5 2.6 2.0 2.3
Current tobacco smoking 0.0 0.1 0.1 -0.3 0.3 0.3 0.0
Average weekly fortified wine intake 0.1 0.1 0.2 0.2 0.5 -0.0 0.4
Maternal smoking around birth 0.6 0.8 1.2 0.7 1.0 1.1 0.8
Fed-up feelings 0.7 1.2 1.6 -1.0 1.1 1.3 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 5.5 0.2 2.0 2.4 2.1
Relative age voice broke 0.7 1.1 1.5 -1.2 -1.1 -1.0 -0.9
Taking other prescription medications 3.3 5.0 7.6 0.8 2.3 2.6 2.8
Age when periods started (menarche) 0.3 0.7 2.5 1.6 0.0 -0.2 -0.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.8 -1.3 -0.6 -0.7 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.4 0.7 0.8 1.2 1.0
Tinnitus: Yes, but not now, but have in the past 2.6 2.8 4.0 1.4 1.7 2.0 1.5
Qualifications: CSEs or equivalent 0.1 0.1 0.5 -0.7 0.0 -0.1 -0.1
Serious illness, injury or assault to yourself 1.2 1.4 5.1 -2.3 0.5 0.3 0.6
High blood pressure 0.4 1.2 1.7 1.2 0.8 1.0 1.3
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.6 0.0 0.7 0.3 0.4
Multivitamins +/- minerals 2.0 2.5 6.3 -2.5 0.9 1.3 1.2
Stomach or abdominal pain in last month 0.2 0.2 0.4 -0.1 -0.6 -0.6 -0.4
Supplements: Glucosamine 1.3 1.7 3.1 0.5 1.4 1.8 1.3
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.5 0.7 0.4 -0.0 0.0
Medication: Atenolol 0.9 1.1 4.0 2.0 0.2 0.4 0.7
Medication: Levothyroxine sodium 1.4 2.4 3.5 0.2 1.9 1.6 1.9
Sitting height 0.8 5.9 14.4 -3.8 -1.5 -1.8 -1.9
Chronic bronchitis/emphysema (father) 2.4 2.8 3.5 -1.7 1.9 1.1 1.8
High blood pressure (mother) 0.0 0.1 0.1 0.3 0.4 -0.1 -0.1
Body mass index (BMI) 0.9 3.6 5.2 1.3 1.9 2.3 2.0
Impedance of leg (left) 0.7 3.2 4.9 -0.3 -2.0 -2.2 -1.9
Leg predicted mass (left) 0.3 1.4 1.7 -1.3 1.1 1.2 1.2
Trunk fat mass 0.8 3.6 4.7 0.9 2.0 2.1 2.2
Waist circumference 0.3 0.9 1.4 -0.1 1.0 1.1 1.2
Number of incorrect matches in round 1.6 2.7 3.3 1.1 1.8 1.8 1.8
Past tobacco smoking 0.5 0.9 1.6 0.8 -1.3 -0.8 -0.8
Alcohol usually taken with meals 0.7 1.2 1.4 0.9 -1.1 -1.2 -1.2
Nervous feelings 0.0 0.1 0.2 -0.4 0.0 -0.0 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.0 -0.5 0.9 0.9 1.0
Hearing difficulty/problems with background noise 0.9 1.4 2.0 -0.6 1.1 1.4 1.4
Hair/balding pattern: Pattern 2 0.5 0.6 1.4 -0.2 -1.2 -0.6 -0.9
Had menopause 0.5 0.6 1.3 -0.2 -0.6 -0.8 -1.1
Had other major operations 0.8 1.0 1.8 -0.8 0.8 1.0 1.3
Forced vital capacity (FVC) 0.5 1.9 3.7 -1.9 -1.2 -1.2 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 1.6 0.6 0.8 1.3 1.0
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.8 -0.2 0.9 0.8 1.3
Qualifications: None of the above 0.6 1.2 3.5 1.9 0.5 0.6 0.8
Financial difficulties in last 2 years 0.4 0.6 1.9 -1.4 0.3 0.1 0.6
Mouth/teeth dental problems 1.7 2.6 3.0 -1.4 -1.7 -1.7 -1.6
Heart attack 0.2 0.2 0.6 0.2 0.2 -0.1 0.8
Allergy 0.3 0.7 1.4 1.2 -1.0 -0.2 -0.6
Pain all over the body in last month 1.1 1.2 3.7 -1.9 0.7 0.2 0.7
Diabetes (self-reported) 1.5 2.3 4.2 -0.5 2.1 1.5 1.6
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 5.1 -2.3 0.3 -0.3 -0.4
Medication: Ramipril 1.2 1.6 2.9 -1.7 1.2 1.0 1.0
Medication: Simvastatin 0.9 1.3 2.2 -0.1 1.1 1.5 1.4
Fluid intelligence score 0.4 0.8 2.2 -1.5 -0.6 -0.2 -0.6
Illnesses of siblings 0.8 1.1 1.9 0.0 -1.4 -1.0 -1.1
Neuroticism score 0.5 1.0 1.3 -1.1 1.0 0.8 1.1
Weight 0.3 1.5 2.1 -0.6 1.3 1.4 1.4
Impedance of arm (right) 0.2 0.7 0.9 -0.7 -0.8 -1.0 -0.9
Arm fat percentage (right) 1.3 5.2 7.2 1.3 2.3 2.7 2.6
Trunk fat-free mass 0.2 1.1 1.6 -1.3 0.8 1.1 0.9
Hip circumference 0.4 1.6 2.4 -0.3 1.3 1.6 1.4
Time employed in main current job 1.9 2.2 3.1 -0.1 1.8 1.7 1.7
Alcohol intake versus 10 years previously 0.1 0.1 0.5 -0.7 -0.3 0.1 -0.1
Father’s age at death 0.1 0.1 0.2 -0.0 0.2 -0.3 -0.5
Worrier / anxious feelings 0.1 0.1 0.2 -0.3 -0.3 -0.4 -0.2
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.7 5.9 -0.8 2.4 2.0 2.1
Falls in the last year 0.1 0.1 0.2 -0.4 0.1 -0.4 0.0
Hair/balding pattern: Pattern 3 0.4 0.6 2.5 1.6 -0.2 -0.0 -0.3
Number of live births 0.6 0.9 1.6 0.6 -1.2 -0.9 -1.0
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 3.9 -2.0 -1.5 -1.4 -1.3
Pulse rate 0.9 1.6 2.5 -0.7 -1.6 -1.3 -1.2
Happiness 2.7 3.3 4.7 0.1 2.2 2.0 2.1
Noisy workplace 0.0 0.0 0.1 0.2 -0.3 0.0 -0.1
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.3 -1.1 0.8 0.7 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 3.0 -0.8 -1.4 -1.7 -1.4
Mouth/teeth dental problems: Dentures 0.6 1.0 1.4 0.5 1.2 1.2 1.0
Asthma 0.6 1.2 2.2 -1.5 1.2 0.8 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.5 0.7 0.5 0.2 0.6
Medication: Cholesterol lowering 1.7 2.6 3.9 -0.3 1.8 1.9 2.0
Depression (self-reported) 0.3 0.3 0.5 0.4 0.7 0.4 0.7
Medication: Lansoprazole 0.8 0.9 1.5 0.2 -1.1 -0.9 -1.2
Prospective memory result 2.2 2.7 4.2 2.1 1.5 1.6 1.4
Lung cancer (father) 2.0 2.3 3.3 -1.0 1.4 1.7 1.8
Illnesses of mother 2.2 2.7 4.6 -0.1 -2.1 -1.8 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.4 4.3 -1.9 -2.1 -1.6 -1.7
Pulse wave Arterial Stiffness index 0.9 1.0 1.5 -0.2 -1.2 -1.1 -1.2
Impedance of arm (left) 0.4 2.0 3.6 -0.7 -1.4 -1.9 -1.5
Arm fat mass (right) 1.0 4.1 6.0 0.7 2.1 2.4 2.3
Trunk predicted mass 0.2 0.9 1.5 -1.2 0.7 1.0 0.8
Standing height 0.4 4.4 13.2 -3.6 -1.0 -1.4 -1.2
Length of working week for main job 0.2 0.3 1.0 -1.0 -0.0 -0.1 0.2
Exposure to tobacco smoke at home 0.2 0.3 0.5 -0.7 0.3 0.6 0.4
Breastfed as a baby 3.3 4.1 6.5 -0.5 -2.5 -2.1 -2.3
Tense / ‘highly strung’ 0.6 1.0 1.5 -1.2 0.9 1.0 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 1.9 -1.4 1.1 1.2 0.6
Hair/balding pattern: Pattern 4 0.4 1.1 3.6 -1.9 0.6 -0.2 0.5
Birth weight of first child 2.3 4.3 5.9 0.7 2.4 2.4 2.3
Peak expiratory flow (PEF) 0.3 0.7 2.6 -1.6 0.1 0.2 0.2
Pulse wave reflection index 0.1 0.1 0.2 -0.4 -0.2 -0.4 -0.4
Ever highly irritable/argumentative for 2 days 1.2 1.5 2.2 0.5 1.5 1.2 1.4
Loud music exposure frequency 1.5 1.6 2.6 -0.7 1.4 1.2 1.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.3 -1.1 -0.5 -0.2 -0.7
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 3.5 1.9 0.7 0.7 1.0
Blood clot in the leg (DVT) 0.9 1.1 1.6 0.5 1.3 1.1 1.3
Medication: Paracetamol 2.7 4.5 6.4 -2.5 2.1 1.8 2.0
Headache pain in last month 0.0 0.0 0.0 -0.2 0.1 -0.2 0.1
Medication for cholesterol, blood pressure or diabetes 5.3 8.7 12.9 -1.1 -3.2 -3.3 -3.6
Glaucoma (self-reported) 0.4 0.4 0.6 -0.7 -0.5 -0.6 -0.7
Gout (self-reported) 0.2 0.3 0.9 1.0 0.1 0.3 0.1
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.3 0.5 1.2 1.0 1.5
Medication: Amlodipine 0.6 0.9 1.8 0.1 -0.7 -1.3 -1.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.5 -1.6 0.8 0.1 0.3
Birth weight 0.3 0.6 0.9 1.0 -0.9 -0.8 -0.4
Chronic bronchitis/emphysema (mother) 4.8 5.6 7.6 0.9 2.8 2.5 2.7
High blood pressure (siblings) 0.1 0.2 0.3 0.3 0.5 0.5 0.3
Forced vital capacity (FVC), Best measure 0.7 2.4 3.3 -1.8 -1.7 -1.4 -1.3
Body fat percentage 1.0 3.8 4.4 1.6 2.0 2.1 2.1
Leg fat percentage (right) 1.2 4.4 5.9 2.4 1.9 2.1 1.9
Arm fat-free mass (right) 0.2 0.8 0.9 -0.8 0.9 1.0 0.9
Exposure to tobacco smoke outside home 1.0 1.3 2.2 -0.3 1.1 1.2 1.5
Comparative body size at age 10 0.3 0.8 1.6 -0.1 0.7 1.1 1.3
Number of full brothers 0.4 0.5 0.8 -0.9 -0.8 -0.6 -0.6
Worry too long after embarrassment 0.6 1.0 1.4 -1.2 -0.8 -1.1 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 3.3 -1.8 -0.4 -0.0 -0.2
Wheeze or whistling in the chest in last year 0.0 0.0 0.1 0.1 0.3 -0.0 0.1
Number of children fathered 2.1 2.4 3.6 -1.2 -1.9 -1.3 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.1 -0.8 -0.0 -1.1 -0.5
Age at first live birth 1.0 1.8 3.1 0.4 -1.4 -1.8 -1.5
Pulse wave peak to peak time 1.1 1.3 1.9 -0.1 1.4 1.3 1.3
Health satisfaction 2.7 3.5 4.0 -1.6 1.9 2.0 1.9
Shortness of breath walking on level ground 0.1 0.1 0.3 -0.5 0.3 0.1 0.3
Qualifications: College or University degree 0.2 0.7 2.4 -1.5 -0.3 -0.5 -0.4
Eye problems/disorders: None of the above 0.5 0.6 1.1 -0.2 0.9 0.7 1.0
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.9 1.7 -0.0 -0.1 -0.2
Emphysema/chronic bronchitis 2.4 2.7 3.5 -0.9 1.9 1.8 1.8
Medication for pain relief, constipation, heartburn 3.8 6.5 9.9 0.8 -2.9 -2.7 -3.1
Neck or shoulder pain in last month 0.5 0.8 3.0 -1.7 0.3 -0.2 -0.1
Medication: Blood pressure 5.0 8.9 11.4 1.9 3.2 3.2 3.4
Angina (self-reported) 0.3 0.4 0.5 -0.4 0.7 0.6 0.7
Migraine (self-reported) 0.4 0.5 1.1 -0.0 -0.7 -0.7 -1.0
Medication: Ibuprofen 0.1 0.1 0.2 0.2 -0.4 -0.5 -0.2
Medication: Allopurinol 1.2 1.6 5.8 2.4 0.2 0.5 0.5
Medication: Omeprazole 2.6 3.2 4.5 0.4 1.9 2.1 2.1
Medication: Seretide 50 evohaler 0.8 0.9 1.3 -0.3 -1.0 -1.1 -1.1
Mean time to correctly identify matches 0.5 0.9 1.2 -0.6 1.1 1.1 1.0
Heart disease (mother) 1.4 1.7 3.5 0.8 1.2 1.9 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.1 0.0 0.1 -0.2 0.2
Whole body fat mass 1.0 4.2 5.5 1.1 2.2 2.3 2.3
Leg fat mass (right) 0.9 3.5 4.5 1.4 1.9 2.1 2.0
Arm predicted mass (right) 0.2 0.9 1.1 -0.7 1.0 1.0 1.0
Pulse rate, automated reading 0.2 0.8 1.6 -0.0 -0.9 -0.9 -1.3
Alcohol intake frequency. 1.1 2.6 3.4 -1.9 1.3 1.8 1.4
Comparative height size at age 10 0.5 3.0 10.5 -3.2 1.0 0.2 0.7
Number of full sisters 0.6 0.8 1.5 0.0 -1.0 -1.2 -0.8
Suffer from ‘nerves’ 0.7 1.1 1.8 -1.3 0.8 0.9 1.0
Overall health rating 2.6 5.6 8.3 -1.6 2.9 2.1 2.7
Chest pain or discomfort 0.5 0.7 1.3 -1.2 -0.5 -0.9 -0.7
Had major operations 0.5 0.6 1.2 -0.1 1.1 0.7 0.8
Age at last live birth 1.3 2.0 3.2 -0.7 -1.3 -1.8 -1.6
Family relationship satisfaction 1.9 2.3 3.3 1.0 1.8 1.3 1.8
Leg pain on walking 0.8 1.0 1.2 -1.0 0.8 1.0 1.1
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.3 2.8 -1.7 1.4 1.6 1.4
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.3 1.2 0.2 -0.2 0.0
Illness, injury, bereavement, stress in last 2 years 0.5 0.7 2.2 1.5 -0.1 0.2 -0.6
Medication: Aspirin 2.7 3.5 4.9 0.3 2.0 2.2 2.2
Supplements: Vitamin C 0.4 0.5 0.8 0.7 0.9 0.8 0.5
Knee pain experienced in last month 0.1 0.2 0.5 -0.7 0.3 0.1 0.4
Hypertension (Self-reported) 0.7 2.0 2.5 1.5 1.1 1.3 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.4 0.3 -0.3 -0.1 -0.6
Illnesses of father: Heart disease 0.2 0.3 1.3 -1.2 0.1 0.2 -0.1
Illnesses of siblings: Diabetes 0.2 0.2 0.5 0.7 0.5 0.2 0.2
Smoking status: Previous 0.7 1.0 1.7 -0.6 1.3 0.9 1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.7 13.0 -3.6 -0.7 -0.7 -0.8
Whole body fat-free mass 0.2 1.3 2.0 -1.4 1.0 1.1 1.0
Leg fat-free mass (right) 0.3 1.5 3.1 -1.8 1.0 1.1 1.0
Arm fat percentage (left) 1.2 5.0 6.3 1.6 2.2 2.5 2.5
Average weekly red wine intake 0.3 0.5 0.7 -0.8 -0.3 -0.7 -0.8
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.9 0.3 -0.6 -0.5 -0.9
Mood swings 1.7 3.0 4.7 -0.5 2.0 2.2 1.8
Loneliness, isolation 2.4 3.3 4.9 -0.9 2.0 1.9 2.2
Long-standing illness, disability or infirmity 9.7 14.8 20.3 -1.2 4.5 4.2 4.5
Ever had bowel cancer screening 0.9 1.0 1.6 0.8 1.3 0.8 1.1
Diabetes diagnosed by doctor 2.1 3.4 4.8 -0.5 2.2 2.1 2.0
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.9 -1.7 -1.1 -0.9 -0.6
Friendships satisfaction 4.5 5.6 7.7 1.1 2.7 2.8 2.5
Qualifications: nursing, teaching 1.6 2.5 3.7 0.1 1.8 1.7 1.9
Commuting to job workplace: Walk 0.3 0.3 1.2 -1.1 -0.1 -0.0 0.1
Eye problems/disorders: Cataract 0.9 1.0 1.4 0.2 -1.1 -1.2 -1.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 -0.1 0.7 0.7 0.4
Medication for cholesterol 0.4 0.6 1.1 0.5 -0.8 -0.7 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.1 0.1 0.4 -0.1 -0.1 -0.2
Back pain experienced in last month 0.4 0.5 0.9 -0.8 -0.5 -1.0 -0.6
Mineral and other dietary supplements 3.2 4.3 5.5 -1.2 -2.3 -2.3 -2.2
Breast cancer (self-reported) 1.0 1.1 1.5 0.6 1.1 1.2 1.2
Asthma (self-reported) 0.6 1.2 3.1 -1.8 1.1 0.6 0.6
Osteoporosis (self-reported) 0.2 0.2 0.7 -0.9 0.2 -0.3 -0.1
Osteoarthritis (self-reported) 2.8 3.7 5.7 -0.2 2.4 2.0 2.2
Medication: Aspirin 2.6 3.4 4.9 0.1 2.0 2.2 2.1
Medication: Gliclazide 0.3 0.3 1.3 -1.2 0.1 -0.1 0.1
Illnesses of father: None of the above (group 1) 0.4 0.4 1.6 1.3 -0.3 -0.1 -0.2
Smoking status: Current 0.0 0.1 0.1 -0.2 0.3 0.3 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 0.9 -0.5 -1.0 -0.7 -0.7
Whole body water mass 0.2 1.4 1.9 -1.4 1.0 1.2 1.0
Leg predicted mass (right) 0.3 1.5 3.4 -1.8 0.9 1.0 0.9
Arm fat mass (left) 0.8 3.1 4.2 1.0 1.8 2.0 2.0
Number of self-reported non-cancer illnesses 0.8 1.3 2.0 -1.3 0.9 0.9 1.4
Average weekly champagne plus white wine intake 1.3 1.8 2.6 0.6 -1.4 -1.5 -1.6
Miserableness 1.7 2.9 3.8 -2.0 1.6 1.6 1.7
Guilty feelings 0.5 0.7 1.1 0.7 -0.8 -1.1 -0.6
Wears glasses or contact lenses 1.1 1.2 1.4 1.1 1.2 1.0 1.1
Ever taken oral contraceptive pill 0.1 0.2 0.5 -0.7 -0.3 0.1 0.2
Hearing aid user 0.7 0.8 1.4 1.2 0.4 0.9 0.9
Mother’s age at death 1.1 1.3 2.3 -0.6 -1.0 -1.5 -1.3
Financial situation satisfaction 1.8 2.3 3.5 -0.6 1.6 1.7 1.9
Tinnitus: Yes, now most or all of the time 0.5 0.6 0.8 -0.6 -0.7 -0.8 -0.9
Commuting to job workplace: Public transport 0.0 0.0 0.1 -0.2 0.1 0.2 0.2
Eye problems/disorders: Glaucoma 0.6 0.7 1.1 -0.8 -0.8 -0.8 -1.1
Medication: Blood pressure 0.1 0.2 0.5 -0.7 -0.2 -0.4 -0.1
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.4 -0.5 0.6 0.4 0.4
Supplements: Fish oil (including cod liver oil) 2.2 2.9 3.3 1.3 1.8 1.8 1.8
High cholesterol (Self-reported) 0.5 0.9 1.4 1.2 0.7 0.9 0.9
Medication: Bendroflumethiazide 0.6 1.0 1.6 0.8 0.8 1.2 1.0
Medication: Paracetamol 2.4 3.8 5.1 -2.3 2.0 1.6 1.9
Medication: Lisinopril 1.3 1.7 3.5 1.9 1.1 1.1 1.0
Medication: Atorvastatin 0.1 0.1 0.2 0.5 -0.5 -0.3 -0.2
Illnesses of father: High blood pressure 0.0 0.1 0.2 0.4 -0.1 -0.2 -0.1
Alcohol drinker status: Never 1.2 1.5 2.4 -0.9 1.6 1.3 1.0
Ever smoked 0.4 0.8 1.3 -0.3 1.2 0.9 0.9
Basal metabolic rate 0.3 1.5 1.7 -1.3 1.1 1.3 1.2
Leg fat percentage (left) 0.9 3.4 3.9 2.0 1.7 1.9 1.8
Arm fat-free mass (left) 0.3 1.3 1.7 -1.0 1.1 1.3 1.1
Number of operations (self-reported) 1.7 2.5 3.5 -0.0 1.9 1.7 1.8
Average weekly beer plus cider intake 0.1 0.2 0.3 -0.2 -0.2 0.6 0.5
Irritability 0.2 0.4 0.7 -0.0 0.8 0.8 0.4
Risk taking 4.1 6.0 9.0 -0.5 2.5 3.0 2.9
Ever had prostate specific antigen (PSA) test 6.2 7.1 8.0 2.8 2.7 2.6 2.5
Fractured/broken bones in last 5 years 0.7 0.9 1.3 0.7 1.1 0.8 1.1
Age started oral contraceptive pill 0.1 0.2 0.4 0.6 0.4 0.1 0.1
Diastolic blood pressure, automated reading 0.8 2.5 3.8 1.2 -1.9 -1.3 -1.7
Ever depressed for a whole week 0.4 0.5 0.8 -0.3 0.9 0.8 0.8
Unable to work because of sickness or disability 2.9 3.7 5.8 -1.0 2.3 1.7 2.4
Commuting to job workplace: Cycle 0.3 0.4 0.6 -0.2 -0.6 -0.6 -0.8
Myopia 0.8 1.1 1.4 0.7 1.1 1.2 1.1
Vascular/heart problems diagnosed by doctor 0.5 1.4 1.9 -1.3 -1.0 -1.1 -1.4
Cholesterol lowering medication 0.7 1.1 1.7 -0.1 -1.3 -1.2 -1.0
Medication: Omeprazole (e.g. Zanprol) 2.3 2.9 3.8 0.8 1.9 2.0 1.9
Pain experienced in last month 0.3 0.4 1.4 1.2 0.0 0.5 -0.1
Supplements: Calcium 0.8 0.9 1.8 -0.6 1.4 0.9 0.7
Basal cell carcinoma (self-reported) 0.4 0.5 1.1 0.3 0.7 1.1 0.5
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.3 0.0 -0.0 -0.3 0.5
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 2.2 0.6 1.4 1.2 1.5
Heart disease (siblings) 0.7 0.8 3.2 -1.8 0.3 -0.1 0.1
Alcohol drinker status: Previous 1.6 1.9 7.1 -2.7 0.4 0.2 0.3
Pack years of smoking 2.2 3.2 4.8 0.6 1.9 2.2 2.0
Impedance of whole body 0.6 2.9 5.0 -0.6 -1.7 -2.2 -1.9
Leg fat mass (left) 0.7 2.7 3.7 1.0 1.8 1.9 1.8
Arm predicted mass (left) 0.2 0.9 1.4 -0.6 0.9 1.2 0.9