Hub : Genes

C1orf133

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0830	0.0410	7.1e-04	0.023	0.033	0.019	NA	0.018	4.7e-03	7.5e-04	8.5e-03	NA	9.9e-03
2	TCGA	Breast Invasive Carcinoma	0.0338	0.0178	6.5e-04	0.018	0.013	0.013	NA	0.014	9.6e-05	1.0e-03	7.8e-04	NA	4.6e-04
3	TCGA	Brain Lower Grade Glioma	0.0320	0.0168	1.3e-03	0.004	0.016	0.011	NA	0.004	9.0e-02	5.9e-03	2.0e-02	NA	1.1e-01
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.1310	0.0700	8.5e-03	-0.002	0.001	-0.001	NA	-0.003	4.7e-01	2.5e-01	3.6e-01	NA	5.3e-01
5	TCGA	Prostate Adenocarcinoma	0.0911	0.0382	4.6e-08	0.100	0.084	0.084	NA	0.092	1.3e-10	4.2e-09	3.9e-09	NA	6.8e-10
6	TCGA	Testicular Germ Cell Tumors	0.1530	0.0700	5.9e-04	0.017	0.075	0.069	NA	0.032	8.0e-02	1.3e-03	1.9e-03	NA	2.6e-02
7	TCGA	Thyroid Carcinoma	0.2970	0.0840	2.3e-14	0.122	0.135	0.170	NA	0.154	6.1e-12	4.2e-13	2.9e-16	NA	8.6e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.2	1.1	-0.2	-0.4	-0.1	-1.1	-0.4	-0.1	-0.1
Bipolar Disorder or Schizophrenia	0.7	1.6	5.6	-1.6	-1.0	-0.3	-2.4	-1.0	-0.1	-1.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	-0.2	-0.7	-1.0	0.6	-0.8	-1.2	-0.6
Depression (Nagel 2018)	0.8	1.2	3.4	0.2	-1.1	-1.8	-0.5	-1.0	-1.2	-0.9
Intelligence (Savage-Jansen 2018)	0.6	1.7	6.8	1.0	-0.1	0.8	2.6	0.9	-0.8	1.4
Neuroticism (Nagel 2018)	0.6	1.3	2.9	-0.8	-1.4	-1.7	0.4	-0.8	-1.7	0.2
Schizophrenia (2018)	0.8	1.8	4.8	-1.9	-0.9	-0.4	-2.2	-1.0	-0.1	-1.4
Schizophrenia vs Biploar Disorder	0.1	0.2	0.8	-0.9	-0.0	0.3	-0.2	-0.3	0.4	-0.0
Worry (Nagel 2018)	0.5	1.1	1.9	-1.4	-1.3	-1.4	-0.7	-0.9	-0.7	-0.7
Alzheimer’s Disease (in mother)	0.4	0.4	0.8	0.4	0.6	0.7	0.3	0.6	0.8	0.9
Alzheimer’s Disease (in father)	1.0	1.1	2.4	1.5	-0.8	-1.1	1.5	0.2	-0.7	1.0
Alzheimer’s Disease (including proxy)	0.3	0.5	1.7	0.6	-0.7	-0.7	1.3	0.0	-0.2	0.5
Crohns Disease (2017)	0.5	1.1	3.2	-0.6	0.9	1.6	-0.8	0.4	1.8	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	-1.0	-0.5	-0.1	-1.1	-0.5	0.7	-0.4
Ulcerative Colitis (UC)	1.1	2.1	4.6	-1.0	-2.1	-2.1	-0.5	-1.5	-1.2	-0.7
Major Depression (MDD)	0.7	0.8	1.9	-0.6	-1.2	-1.0	0.0	-1.4	-0.8	-0.8
Reaction Time	0.7	1.3	3.3	-1.1	-1.8	-1.7	-0.8	-1.1	0.2	0.2
Verbal and Numeric Reasoning (VNR)	0.7	1.8	7.1	1.2	-0.4	-0.1	2.7	0.5	-1.2	1.4
Breast Cancer	1.5	3.6	7.6	2.8	1.3	1.2	1.9	2.2	1.0	2.2
Ovarian Cancer	1.7	2.2	4.5	-1.5	-2.1	-1.4	0.3	-1.6	-1.7	-1.1
Prostate Cancer	1.0	1.4	3.4	-0.0	1.4	1.8	-0.2	1.3	1.2	1.1
Age at First Birth	0.9	1.3	2.6	1.6	-1.1	-1.1	1.4	0.4	-0.1	1.6
Bipolar Disorder (2011)	0.2	0.1	0.5	0.4	-0.3	-0.5	-0.0	0.1	-0.7	-0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.2	-0.6	-0.7	0.5	-1.0	-0.3	-0.4
Coronary Artery Disease (CAD)	1.2	1.4	2.4	-1.2	-1.3	-1.3	-1.2	-1.5	-0.8	-0.9
Crohns Disease (2012)	0.7	1.1	2.6	-1.6	0.2	1.4	-1.0	-0.5	1.3	-0.2
Mean Putamen Volume	0.3	0.3	1.3	-0.1	-0.7	-0.5	-0.1	-0.5	0.2	1.1
Fasting Glucose	0.2	0.3	0.6	0.5	0.8	0.5	-0.2	0.7	0.3	-0.1
HbA1C	1.3	1.4	5.1	0.3	-1.2	-2.3	0.5	-1.2	-1.2	-0.4
HDL Cholesterol	1.2	1.9	5.3	1.8	-0.9	-1.5	2.3	0.1	-1.3	0.5
LDL Cholesterol	1.5	2.3	3.8	-1.4	-1.8	-1.9	-0.3	-1.9	-1.7	-0.9
Lupus	1.3	2.0	6.1	0.9	1.6	1.2	-1.1	1.2	2.5	0.4
Neuroticism (2016)	0.5	0.7	2.2	-1.5	-0.9	-0.3	-0.3	-0.9	-0.6	-0.8
Primary Biliary Cirrhosis	0.2	0.2	0.7	-0.3	0.1	-0.0	-0.8	0.5	0.5	0.6
Rheumatoid Arthritis	4.0	5.5	12.0	1.3	3.0	2.6	-1.9	2.3	3.5	0.9
Schizophrenia (2014)	0.5	1.0	2.4	-1.5	-0.8	-0.5	-1.3	-0.9	-0.5	-0.9
Triglycerides	0.3	0.5	1.2	-0.5	0.0	-0.6	-0.7	-0.9	-0.3	-1.1
Type 2 Diabetes (T2D) (2012)	2.9	3.4	7.5	-2.7	-2.0	-0.8	-1.3	-2.3	-1.2	-1.7
Ulcerative Colitis	0.8	1.1	3.6	-0.2	-1.5	-1.9	-0.0	-0.9	-0.9	-0.7
Blood Eosinophil Count	0.1	1.1	2.0	-0.9	-1.1	-1.0	0.1	-1.3	-1.4	-0.9
Blood Platelet Count	0.2	2.2	4.9	-1.4	-1.4	-1.4	0.3	-2.2	-1.7	-1.2
Blood Red Count	0.2	1.6	3.8	0.7	1.7	1.9	0.6	0.7	1.8	0.4
Blood White Count	0.3	2.1	5.1	-1.8	0.1	0.1	-1.8	-1.6	0.0	-2.2
Heel T-Score	2.8	22.1	35.6	-4.1	-4.2	-4.9	-6.0	-4.4	-2.8	-5.8
BMI	0.8	4.8	16.6	1.6	-1.2	-1.8	4.1	-1.7	-2.7	0.1
Height	0.5	10.0	26.1	-5.1	-2.0	-0.5	-2.3	-3.3	-1.2	-4.7
Waist Hip Ratio (WHR)	0.7	3.0	8.1	-2.9	-1.1	-0.6	-2.0	-2.0	-0.2	-1.8
Systolic Blood Pressure	1.0	5.0	12.3	-2.4	-1.8	-1.8	-2.1	-3.5	-0.6	-2.5
Smoking Status	4.4	10.6	23.8	-4.1	-1.8	-1.4	-4.2	-3.0	-1.4	-4.9
Allergy or Eczema	0.6	1.5	3.1	-1.8	-1.6	-0.6	-1.1	-1.3	-0.8	-1.2
Cardiovascular Disease	1.4	4.6	10.0	-3.2	-0.2	0.8	-2.7	-2.0	0.2	-3.1
Hypothyroidism (self reported)	2.3	5.2	11.0	-2.2	-1.9	-2.0	-1.5	-2.5	-2.0	-3.3
Respiratory disease	1.5	3.4	7.1	-1.5	-2.2	-1.6	0.9	-2.3	-2.7	-1.0
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.9	-0.4	-0.3	0.0	0.5	-1.0	0.0	-0.7
Lung FEV1/FVC ratio	0.6	3.2	7.2	-2.5	-1.3	-0.5	-2.7	-1.5	0.5	-2.1
Lung FVC	2.1	10.5	26.0	-3.8	-2.9	-2.3	-5.1	-2.7	-1.1	-3.4
Neuroticism	0.1	0.2	0.8	0.3	-0.2	-0.5	0.5	0.4	-0.0	0.9
Chronotype (morning person)	1.5	3.5	7.2	1.9	1.7	1.5	2.0	2.1	0.8	2.7
Hair Pigment	0.0	0.3	0.7	-0.1	-0.8	-0.8	0.1	-0.4	-0.7	-0.3
Tanning	0.5	5.8	9.4	-2.3	-2.4	-2.5	-1.1	-2.6	-3.1	-2.3
Hand grip strength (left)	0.6	1.5	3.1	-1.1	-1.4	-1.4	-0.3	-1.8	-1.2	-1.0
Number of treatments/medications taken	1.2	2.1	3.6	-1.7	1.1	1.9	-1.6	-0.6	1.3	-1.5
Average weekly spirits intake	1.1	1.3	3.3	1.8	1.5	0.8	1.2	0.9	0.8	0.7
Sensitivity / hurt feelings	1.7	3.0	5.4	-1.0	-1.9	-2.3	-0.5	-1.8	-1.8	-2.0
Frequency of depressed mood in last 2 weeks	1.0	1.3	2.3	-0.7	-1.1	-1.5	-0.8	-1.1	-1.5	-1.1
Hearing difficulty/problems: Yes	2.1	3.2	6.9	-0.5	-2.4	-2.6	0.6	-2.0	-2.1	-1.0
Relative age of first facial hair	0.1	0.2	0.8	-0.2	0.2	0.5	-0.4	0.2	0.9	-0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.2	-0.3	-1.0	-0.8	1.1	-0.7	-1.5	-0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.2	-1.2	-1.1	-0.6	0.0	-1.5	-1.0	-1.0
Ever had hysterectomy (womb removed)	0.4	0.4	1.6	0.2	0.6	0.3	-1.3	-0.3	0.9	-0.0
Systolic blood pressure, automated reading	0.6	1.6	6.7	-0.5	-1.5	-1.2	0.8	-2.6	-0.4	0.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.8	0.7	-0.0	-0.3	1.3	-0.3	-0.4	-0.2
Angina	1.2	1.6	3.8	-0.6	-1.2	-1.3	0.5	-1.9	-1.6	-1.2
Medication for hormone replacement therapy	0.7	0.8	1.9	0.3	0.8	1.4	-0.6	0.9	1.1	1.0
Vitamin and mineral supplements	0.7	0.9	3.0	-1.0	0.3	0.7	-1.1	-0.4	0.5	-1.7
Supplements: Zinc	0.9	0.9	2.1	0.7	-1.1	-1.5	1.2	-0.7	-0.9	0.5
Medication: Co-codamol	0.6	0.7	1.6	0.8	1.3	-0.1	-1.2	0.2	1.2	0.1
Medication: Metformin	0.6	0.8	3.2	-1.1	0.0	0.4	-0.4	-0.9	0.2	-1.8
Diabetes (father)	2.2	2.8	4.2	-1.8	-1.5	-1.5	-1.7	-2.1	-1.3	-1.7
Diabetes (mother)	1.0	1.3	3.0	1.2	-0.9	-1.3	1.7	-0.4	-1.3	0.7
Severe depression (siblings)	0.6	0.6	1.8	-0.7	-0.4	-0.5	-1.0	-0.6	-0.5	-1.3
Pack years adult smoking proportion	0.3	0.5	1.0	0.0	0.5	0.9	-0.4	-0.3	0.9	-1.0
Impedance of leg (right)	1.5	7.3	19.8	-3.8	-0.8	-0.2	-4.5	-1.4	0.3	-3.8
Leg fat-free mass (left)	0.5	2.4	10.5	0.8	-0.8	-0.6	3.2	-1.1	-1.8	0.7
Trunk fat percentage	1.0	4.0	10.1	0.3	-1.3	-1.7	3.2	-2.4	-2.6	-1.0
Hand grip strength (right)	0.6	1.5	2.8	-1.7	-0.9	-1.0	-1.4	-1.3	-0.7	-1.4
Townsend deprivation index at recruitment	0.3	0.4	0.9	0.0	-0.7	-0.9	0.4	-0.4	-0.8	-0.7
Current tobacco smoking	2.7	4.4	14.6	-2.2	0.8	1.4	-3.8	-0.7	1.6	-2.4
Average weekly fortified wine intake	2.1	2.5	5.1	0.6	2.1	1.7	-1.0	1.9	2.3	0.5
Maternal smoking around birth	0.5	0.7	1.7	-1.3	-0.6	0.1	-0.0	-1.0	-0.6	-1.3
Fed-up feelings	0.3	0.5	1.3	0.0	-0.4	-0.9	0.4	-1.1	-1.1	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.6	-0.0	-0.9	-1.6	-0.2	-1.1	-1.3	-1.1
Relative age voice broke	0.6	0.9	3.0	-1.0	0.0	0.5	-1.7	0.2	1.4	-0.4
Taking other prescription medications	0.8	1.3	4.5	-1.6	-0.1	0.4	-0.7	-1.0	-0.5	-2.1
Age when periods started (menarche)	0.4	1.0	2.8	-1.7	-0.6	0.3	-0.1	-1.0	-1.1	-1.2
Bilateral oophorectomy (both ovaries removed)	1.2	1.3	2.9	-1.4	-0.7	-0.6	-1.7	-1.4	-0.4	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.3	-0.1	-0.6	-1.1	-0.8	-0.3	-0.9	-1.1
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	7.8	-2.0	-0.3	0.1	-2.8	-0.9	-0.2	-2.8
Qualifications: CSEs or equivalent	1.2	1.6	4.3	0.7	-1.0	-1.2	2.1	-0.8	-1.8	0.6
Serious illness, injury or assault to yourself	0.1	0.1	0.5	-0.7	-0.2	0.5	0.3	-0.2	-0.3	-0.0
High blood pressure	0.5	1.4	2.9	-1.4	0.3	0.6	-1.4	-1.5	0.4	-1.7
Hayfever, allergic rhinitis or eczema	0.6	1.4	4.2	-2.0	-1.2	-0.1	-1.2	-1.1	-0.3	-1.0
Multivitamins +/- minerals	0.7	0.9	1.6	0.1	-1.3	-1.1	1.0	-0.5	-0.9	1.2
Stomach or abdominal pain in last month	2.4	3.0	5.0	-1.6	-1.7	-1.3	-0.8	-2.2	-2.0	-2.1
Supplements: Glucosamine	1.9	2.4	6.0	-0.2	-1.9	-2.4	0.5	-2.0	-1.8	-0.1
Diverticular disease/diverticulitis (self-reported)	4.8	5.7	8.8	-2.0	-2.8	-2.9	-0.2	-3.0	-2.6	-2.0
Medication: Atenolol	0.6	0.7	1.5	-1.2	0.7	1.2	-1.1	-0.1	0.6	0.2
Medication: Levothyroxine sodium	3.2	5.4	10.9	-1.9	-2.2	-2.5	-1.1	-2.6	-2.1	-3.3
Sitting height	0.5	3.2	6.3	-2.5	-1.7	-0.7	0.0	-2.0	-2.2	-2.1
Chronic bronchitis/emphysema (father)	1.0	1.2	4.1	1.6	0.5	-0.6	2.0	0.3	-0.9	0.4
High blood pressure (mother)	2.1	2.9	9.4	-1.5	-0.6	-0.4	-3.1	-1.5	0.1	-2.5
Body mass index (BMI)	1.1	4.8	17.2	2.0	-0.8	-1.8	4.2	-1.6	-2.3	0.6
Impedance of leg (left)	1.7	8.2	18.3	-4.1	-1.1	-0.5	-4.3	-1.7	-0.4	-4.2
Leg predicted mass (left)	0.4	2.3	10.0	0.9	-0.7	-0.6	3.2	-1.0	-1.7	0.7
Trunk fat mass	1.1	4.7	11.1	0.2	-1.5	-1.9	3.3	-2.6	-2.8	-1.1
Waist circumference	1.6	5.9	12.3	0.2	-2.0	-2.6	3.5	-3.0	-3.0	-0.6
Number of incorrect matches in round	0.5	0.8	1.6	-1.3	-0.8	-1.0	-0.7	-1.0	-0.5	-0.5
Past tobacco smoking	6.2	11.4	15.4	3.4	3.4	3.5	2.0	3.7	3.4	3.9
Alcohol usually taken with meals	1.4	2.3	6.8	-0.7	1.6	2.6	-1.5	1.4	1.3	-0.4
Nervous feelings	0.3	0.5	1.5	-1.2	-0.8	-0.7	-0.4	-0.8	-0.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.6	6.4	-2.5	-2.5	-2.2	-1.1	-2.3	-2.0	-2.0
Hearing difficulty/problems with background noise	1.0	1.5	3.3	-1.4	-1.8	-1.3	0.1	-1.6	-1.2	-0.4
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.3	-0.4	-0.5	-0.9	-0.1	0.7	-0.4
Had menopause	0.1	0.1	0.6	-0.2	-0.2	0.1	0.8	-0.1	-0.2	-0.2
Had other major operations	0.7	0.8	2.2	-0.3	-0.6	-0.3	1.3	-0.9	-1.5	-0.6
Forced vital capacity (FVC)	1.2	4.7	8.9	-3.0	-1.9	-1.0	-2.8	-1.7	-1.7	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.5	-0.7	-1.2	-1.6	-1.2	-0.8	-1.2	-1.1
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	2.1	-0.8	-0.7	-0.4	0.0	-0.8	-1.4	-0.9
Qualifications: None of the above	0.9	1.8	5.0	-0.9	-1.5	-1.4	0.2	-2.2	-1.0	-1.3
Financial difficulties in last 2 years	0.6	0.8	2.1	1.2	-0.0	-0.1	1.4	0.1	-0.7	1.1
Mouth/teeth dental problems	3.5	5.3	9.0	2.5	2.2	2.1	1.7	2.6	1.9	3.0
Heart attack	0.1	0.1	0.3	0.6	-0.1	0.1	0.6	-0.2	-0.3	-0.1
Allergy	1.9	4.3	7.6	2.8	2.4	1.0	0.3	2.4	2.3	2.0
Pain all over the body in last month	1.0	1.0	2.8	-0.6	-1.0	-0.7	1.1	-1.7	-1.2	-0.3
Diabetes (self-reported)	0.1	0.2	0.4	-0.2	0.3	0.3	0.0	-0.6	0.5	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	0.7	0.1	-0.2	0.5	0.2	0.1	-0.1
Medication: Ramipril	0.4	0.5	1.5	-1.0	0.2	0.7	-0.3	-0.6	-0.3	-1.2
Medication: Simvastatin	5.4	8.0	14.4	-2.3	-3.4	-3.3	0.4	-3.8	-3.0	-2.2
Fluid intelligence score	0.8	1.6	4.0	1.5	0.9	1.0	2.0	1.5	-0.2	1.0
Illnesses of siblings	0.7	1.0	2.6	1.6	0.8	0.2	0.9	1.1	0.7	1.1
Neuroticism score	0.1	0.1	0.3	-0.3	-0.3	-0.5	0.1	-0.1	-0.3	0.6
Weight	0.8	4.1	13.0	0.5	-1.2	-1.4	3.6	-2.2	-2.7	-0.4
Impedance of arm (right)	0.4	1.7	3.3	-1.7	0.5	1.8	-1.6	0.9	1.5	0.3
Arm fat percentage (right)	1.0	3.8	16.2	1.5	-0.6	-1.2	4.0	-1.5	-2.0	0.5
Trunk fat-free mass	0.4	2.2	4.2	-0.1	-1.5	-1.3	2.0	-1.9	-2.0	-0.4
Hip circumference	1.6	6.7	27.5	2.0	-1.1	-1.9	5.2	-1.5	-2.6	1.1
Time employed in main current job	0.4	0.4	1.3	-1.1	-0.9	-0.2	-0.1	-0.8	0.2	-0.2
Alcohol intake versus 10 years previously	0.8	1.2	2.2	1.1	1.0	1.3	1.2	0.8	0.7	1.5
Father’s age at death	0.1	0.2	0.4	-0.4	-0.4	0.0	-0.5	-0.3	-0.3	-0.6
Worrier / anxious feelings	0.5	1.0	2.4	-1.5	-1.6	-0.9	-0.4	-0.9	-0.9	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.9	-0.4	-0.2	-0.3	-0.5	-0.9	0.1	-0.8
Falls in the last year	0.4	0.6	2.0	-0.1	-0.9	-1.4	-0.2	-0.9	-0.5	-0.1
Hair/balding pattern: Pattern 3	0.3	0.5	1.0	1.0	0.5	0.6	0.2	0.5	0.8	0.9
Number of live births	1.2	1.7	3.2	-0.2	-1.4	-1.2	1.5	-1.6	-1.8	-0.3
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	10.1	-3.1	-1.8	-1.0	-3.2	-1.8	-1.3	-2.6
Pulse rate	1.2	2.0	4.2	1.6	1.5	1.0	0.9	1.1	1.4	2.0
Happiness	2.0	2.4	5.9	-0.4	-2.2	-2.4	0.1	-1.6	-1.8	0.1
Noisy workplace	0.2	0.2	0.6	0.2	0.2	0.0	-0.6	-0.1	0.8	0.7
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.6	-0.0	1.5	2.0	-0.7	2.1	1.2	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	3.7	0.4	1.0	1.9	0.9	1.8	1.3	1.8
Mouth/teeth dental problems: Dentures	1.5	2.5	7.1	-2.0	-0.5	-0.5	-1.8	-1.5	-0.5	-2.7
Asthma	1.3	2.6	7.0	-1.1	-1.7	-1.0	1.8	-1.6	-2.6	-0.5
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	9.9	2.3	3.1	2.2	0.4	2.5	2.1	1.6
Medication: Cholesterol lowering	2.3	3.6	7.3	-2.2	-1.5	-1.2	-1.1	-2.4	-1.5	-2.7
Depression (self-reported)	2.3	2.7	5.5	-1.8	-1.2	-1.3	-2.2	-1.2	-0.8	-2.3
Medication: Lansoprazole	0.9	1.0	4.8	-1.1	-0.1	0.5	-0.6	-0.6	-0.5	-2.2
Prospective memory result	1.7	2.1	4.7	1.6	1.1	1.0	0.5	1.6	1.5	2.2
Lung cancer (father)	0.5	0.6	1.1	-1.0	-0.5	-0.4	-0.9	-1.1	0.2	-0.7
Illnesses of mother	0.5	0.6	1.5	-0.5	-1.1	-0.5	1.2	-0.5	-0.9	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	10.1	-3.2	-1.5	-0.4	-3.2	-1.7	-0.8	-2.6
Pulse wave Arterial Stiffness index	0.6	0.7	2.6	0.6	1.6	1.1	0.1	0.7	0.6	0.2
Impedance of arm (left)	0.5	2.4	6.5	-1.4	1.1	2.5	-1.4	1.3	1.9	0.5
Arm fat mass (right)	1.0	4.1	15.1	1.3	-0.9	-1.5	3.9	-1.9	-2.4	0.0
Trunk predicted mass	0.4	2.1	3.9	-0.1	-1.4	-1.3	1.9	-1.8	-2.0	-0.4
Standing height	0.3	2.7	10.0	-3.2	-1.0	0.7	-0.6	-1.5	-1.1	-2.0
Length of working week for main job	3.7	4.1	8.1	1.3	2.4	2.8	0.1	2.3	2.5	1.2
Exposure to tobacco smoke at home	0.7	0.8	2.0	-0.8	-1.4	-1.0	-0.4	-1.2	0.1	0.1
Breastfed as a baby	0.3	0.4	1.4	0.4	0.5	0.6	-0.7	0.4	1.2	-0.4
Tense / ‘highly strung’	0.6	1.1	2.6	-1.6	-1.0	-0.8	-1.4	-1.0	-0.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	6.6	-1.7	-2.0	-2.6	-1.4	-2.1	-1.8	-1.5
Hair/balding pattern: Pattern 4	0.2	0.5	1.6	0.1	0.1	-0.8	-1.3	0.7	0.6	0.5
Birth weight of first child	0.3	0.5	1.2	1.1	0.7	0.5	0.3	0.9	0.9	0.2
Peak expiratory flow (PEF)	0.5	1.1	1.7	-1.3	-0.9	-0.4	-0.9	-1.0	-1.3	-1.3
Pulse wave reflection index	0.7	0.9	2.3	1.0	1.5	0.8	0.2	1.2	0.6	0.5
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.7	0.5	0.2	0.0	-0.1	0.4	0.2	0.9
Loud music exposure frequency	2.7	2.9	4.8	1.0	2.2	2.2	-1.1	1.9	2.2	0.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.9	-0.7	0.9	1.2	-1.7	1.0	1.2	-0.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	1.9	-0.6	-1.3	-1.4	-0.1	-1.0	-1.4	-0.9
Blood clot in the leg (DVT)	0.0	0.1	0.2	-0.1	0.2	0.4	-0.1	0.1	0.4	0.1
Medication: Paracetamol	0.8	1.4	4.6	-0.9	1.5	2.1	-0.7	0.5	1.1	-0.3
Headache pain in last month	0.3	0.5	1.6	-0.7	0.5	0.3	-1.1	-0.1	-0.3	-1.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.0	0.5	-0.7	-0.9	0.6	0.5	-0.1	1.4
Glaucoma (self-reported)	0.5	0.6	1.3	0.3	-1.1	-0.9	1.0	-0.6	-0.6	0.1
Gout (self-reported)	0.6	0.8	2.3	-1.1	-0.2	0.1	-1.5	-0.7	0.3	-1.2
Hypothyroidism/myxoedema (self-reported)	3.6	7.1	12.0	-2.4	-2.6	-2.8	-2.0	-3.0	-2.0	-3.5
Medication: Amlodipine	0.5	0.7	2.2	-1.2	-0.2	0.2	-0.6	-1.0	-0.4	-1.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	-0.2	-0.0	0.4	0.8	-0.2	-0.4	0.9
Birth weight	0.6	1.2	2.7	1.2	-0.6	-1.6	1.6	-0.5	-1.1	0.0
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.9	0.9	0.6	0.1	0.7	0.7	0.1	0.9
High blood pressure (siblings)	0.5	0.7	1.3	-1.1	-0.8	-0.8	-0.4	-0.9	-0.9	-0.6
Forced vital capacity (FVC), Best measure	1.4	5.1	10.4	-3.2	-2.0	-0.8	-2.5	-2.1	-1.6	-2.7
Body fat percentage	1.1	4.5	9.2	0.3	-1.4	-2.1	3.0	-2.6	-2.7	-1.3
Leg fat percentage (right)	1.4	5.1	9.6	-0.2	-1.8	-2.6	2.1	-3.1	-2.7	-2.1
Arm fat-free mass (right)	0.5	2.8	5.6	0.1	-1.3	-1.6	2.2	-2.0	-2.4	-0.8
Exposure to tobacco smoke outside home	0.9	1.2	3.4	-0.3	-0.8	-1.8	-0.5	-1.2	-1.0	-1.3
Comparative body size at age 10	0.2	0.6	2.9	1.7	0.0	-0.3	0.7	0.4	0.4	0.8
Number of full brothers	4.1	5.1	8.6	-1.6	-2.9	-2.6	1.1	-2.9	-2.8	-0.9
Worry too long after embarrassment	0.4	0.7	2.6	-0.8	-1.0	-1.6	-0.7	-0.1	-0.7	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	6.1	-0.7	-1.9	-2.5	-0.5	-2.0	-2.0	-0.8
Wheeze or whistling in the chest in last year	5.6	10.0	17.8	-3.6	-3.4	-2.4	-1.3	-4.2	-2.9	-3.4
Number of children fathered	0.9	1.0	2.4	-1.2	-0.4	-0.6	-0.9	-1.1	-0.7	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.7	-1.2	-0.9	-1.2	-2.2	-0.6	-0.2	-1.8
Age at first live birth	1.2	2.1	3.8	1.1	1.0	0.8	-0.9	1.9	1.8	1.9
Pulse wave peak to peak time	0.8	0.9	2.8	-1.0	-1.7	-1.0	-0.3	-0.8	-0.7	-0.5
Health satisfaction	0.2	0.2	0.6	0.7	-0.2	-0.4	0.5	-0.0	-0.8	0.3
Shortness of breath walking on level ground	0.3	0.4	1.2	-0.9	-0.4	0.7	0.2	-1.1	-0.0	-0.0
Qualifications: College or University degree	2.1	6.7	12.3	1.6	3.1	3.4	-0.5	3.5	2.5	1.9
Eye problems/disorders: None of the above	1.3	1.5	4.1	-0.1	1.4	0.9	-2.0	1.2	1.5	-0.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.5	0.7	1.6	1.3	-0.9	1.4	1.6	0.3
Emphysema/chronic bronchitis	2.1	2.4	5.2	-1.4	-1.6	-1.1	-0.6	-2.1	-1.0	-2.3
Medication for pain relief, constipation, heartburn	0.8	1.4	3.8	0.1	-1.9	-2.0	0.5	-0.5	-1.4	0.3
Neck or shoulder pain in last month	0.2	0.3	1.3	-0.2	-0.2	-0.2	0.1	-0.4	-0.9	-1.1
Medication: Blood pressure	0.9	1.6	4.4	0.5	2.0	2.1	-0.3	0.8	1.2	-0.2
Angina (self-reported)	1.3	1.8	4.0	-0.5	-1.2	-1.3	0.6	-2.0	-1.7	-1.2
Migraine (self-reported)	0.7	0.9	2.2	0.5	1.4	1.5	0.1	0.7	0.9	0.9
Medication: Ibuprofen	4.9	5.9	12.6	2.6	3.5	2.4	0.1	2.8	2.3	1.7
Medication: Allopurinol	0.3	0.4	1.3	0.5	0.5	0.1	-1.0	-0.0	1.1	-0.3
Medication: Omeprazole	0.9	1.1	2.9	-0.2	1.7	1.6	-1.0	0.4	1.0	-0.2
Medication: Seretide 50 evohaler	1.5	1.8	3.9	0.5	1.6	2.0	-0.8	1.2	1.8	0.6
Mean time to correctly identify matches	1.5	2.8	5.3	-1.7	-2.3	-2.3	-1.3	-1.9	-0.1	-0.9
Heart disease (mother)	1.7	2.1	3.9	0.6	1.9	1.8	-1.2	1.3	2.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.1	1.0	0.6	0.3	0.8	0.3	0.2	0.4
Whole body fat mass	1.1	4.4	10.9	0.4	-1.3	-1.8	3.3	-2.5	-2.8	-1.2
Leg fat mass (right)	1.2	4.8	8.6	0.3	-1.5	-2.2	2.9	-2.8	-2.8	-1.4
Arm predicted mass (right)	0.6	3.1	6.0	-0.1	-1.6	-1.7	2.1	-2.3	-2.5	-0.9
Pulse rate, automated reading	0.2	0.8	2.8	0.3	0.7	0.9	-0.7	0.5	1.7	0.8
Alcohol intake frequency.	1.1	2.5	5.2	2.3	1.6	1.2	1.2	0.9	1.5	2.0
Comparative height size at age 10	0.5	3.0	8.1	-2.8	-0.7	0.2	-1.8	-1.3	-0.7	-2.6
Number of full sisters	0.2	0.2	0.7	-0.1	-0.1	-0.1	-0.3	-0.8	0.1	-0.8
Suffer from ‘nerves’	0.2	0.2	0.8	-0.9	-0.1	-0.0	-0.5	-0.5	0.4	-0.5
Overall health rating	1.3	2.8	5.3	-1.8	-1.3	-1.2	-1.3	-2.3	-1.0	-2.2
Chest pain or discomfort	0.6	0.8	2.0	-1.2	-0.9	-0.7	-0.3	-1.4	-0.8	-0.8
Had major operations	0.7	0.8	2.6	-0.7	-0.5	-0.1	-1.2	-0.6	-0.5	-1.6
Age at last live birth	0.5	0.7	1.9	0.3	-1.4	-1.1	0.4	-0.2	-0.6	1.1
Family relationship satisfaction	2.0	2.5	5.4	-1.4	-1.9	-1.8	-0.7	-2.3	-1.2	-1.1
Leg pain on walking	1.6	2.0	3.5	-1.7	-1.0	-0.7	-1.5	-1.8	-0.7	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.7	0.5	-0.5	-0.8	0.2	-0.6	-0.4	-0.5
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.8	0.2	-1.6	-1.9	1.0	-1.2	-1.4	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.5	0.5	0.5	-0.0	-0.1	0.7	0.4	0.0
Medication: Aspirin	0.8	1.1	3.3	-1.5	-0.2	0.4	-0.7	-1.1	-0.2	-1.8
Supplements: Vitamin C	1.8	2.1	5.5	1.6	-0.8	-1.0	2.3	-0.4	-0.8	2.1
Knee pain experienced in last month	3.4	5.3	8.3	-1.1	-2.1	-2.8	-2.4	-2.9	-1.1	-2.8
Hypertension (Self-reported)	0.7	1.9	3.5	-1.3	0.9	1.3	-1.9	-1.1	1.0	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.5	-0.5	1.4	1.6	-1.4	0.6	1.4	-0.9
Illnesses of father: Heart disease	0.2	0.3	1.2	0.1	0.1	-0.3	0.3	-0.7	-0.6	-1.1
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.0	-0.6	-0.1	-0.2	-0.5	0.0	0.0
Smoking status: Previous	6.4	9.6	14.7	-2.3	-3.4	-3.8	-0.5	-3.6	-3.8	-2.9
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.5	-2.1	-1.4	-0.1	-0.4	-1.9	-0.9	-1.3
Whole body fat-free mass	0.4	2.3	6.2	0.2	-1.2	-1.1	2.5	-1.7	-2.1	-0.1
Leg fat-free mass (right)	0.5	2.7	12.2	1.1	-0.6	-0.5	3.5	-0.8	-1.9	0.9
Arm fat percentage (left)	0.9	3.6	15.8	1.5	-0.5	-1.1	4.0	-1.5	-1.9	0.4
Average weekly red wine intake	2.2	3.3	11.1	-2.3	-0.8	-0.2	-3.3	-0.8	0.3	-2.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	-0.5	-0.2	-0.1	-0.7	-0.1	0.1	-0.1
Mood swings	0.1	0.2	0.6	0.1	0.5	0.3	-0.4	0.8	0.4	0.3
Loneliness, isolation	0.4	0.6	1.8	0.5	0.1	-0.6	1.0	-0.6	-1.3	-0.3
Long-standing illness, disability or infirmity	2.6	4.0	8.8	-1.6	-2.2	-1.7	0.7	-3.0	-2.4	-1.6
Ever had bowel cancer screening	0.7	0.8	2.1	-0.9	-0.8	-0.6	-0.3	-1.0	-0.6	-1.4
Diabetes diagnosed by doctor	0.1	0.2	0.4	-0.3	0.4	0.6	0.3	-0.5	0.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.8	-0.3	0.0	0.7	0.9	0.4	-1.3	0.8
Friendships satisfaction	1.3	1.6	4.2	0.2	-1.6	-2.0	0.4	-1.5	-1.4	-0.0
Qualifications: nursing, teaching	1.9	2.9	5.5	0.8	2.1	2.4	-0.8	1.9	2.3	0.5
Commuting to job workplace: Walk	0.2	0.2	0.7	-0.0	-0.6	-0.8	0.1	-0.6	-0.2	0.2
Eye problems/disorders: Cataract	2.5	2.9	5.2	-0.8	-2.3	-1.4	1.6	-2.1	-2.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	6.8	-0.6	-2.0	-1.6	1.7	-1.6	-2.6	0.1
Medication for cholesterol	0.3	0.5	1.4	1.2	-0.2	-0.3	1.0	0.7	-0.1	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.0	-0.2	1.0	0.8	-0.6	0.5	0.4	-0.8
Back pain experienced in last month	0.5	0.7	1.8	1.0	1.4	1.0	-0.0	1.0	0.1	0.3
Mineral and other dietary supplements	1.2	1.6	3.0	-1.7	0.5	1.4	-1.6	0.4	0.9	-1.6
Breast cancer (self-reported)	0.2	0.2	0.5	0.1	-0.5	-0.7	0.7	-0.5	-0.4	0.1
Asthma (self-reported)	1.3	2.6	7.2	-1.1	-1.8	-1.2	1.6	-1.6	-2.7	-0.8
Osteoporosis (self-reported)	1.3	1.6	2.2	1.1	1.5	1.5	0.8	1.4	1.1	1.2
Osteoarthritis (self-reported)	0.3	0.4	1.0	0.5	0.2	0.2	-0.5	-0.5	0.9	-1.0
Medication: Aspirin	0.5	0.7	2.2	-1.0	-0.2	0.2	-0.3	-1.0	-0.3	-1.5
Medication: Gliclazide	1.1	1.3	3.2	-1.8	-0.4	0.0	-0.9	-1.5	-0.1	-1.6
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	-0.3	-0.0	0.7	-0.7	0.5	0.9	0.6
Smoking status: Current	2.7	4.3	13.8	-2.5	0.4	1.1	-3.7	-0.9	1.2	-2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	0.6	0.2	-0.5	-0.9	0.5	0.7	0.8
Whole body water mass	0.4	2.3	5.8	0.1	-1.3	-1.2	2.4	-1.7	-2.1	-0.2
Leg predicted mass (right)	0.5	2.7	11.8	1.0	-0.7	-0.5	3.4	-0.8	-1.9	0.9
Arm fat mass (left)	1.1	4.5	16.5	1.2	-1.0	-1.5	4.1	-2.0	-2.6	0.0
Number of self-reported non-cancer illnesses	1.1	1.9	5.2	-1.9	-0.6	0.0	-0.4	-1.6	-1.2	-2.3
Average weekly champagne plus white wine intake	0.8	1.1	2.4	0.6	0.9	0.9	-1.3	1.2	1.5	0.7
Miserableness	0.8	1.3	2.2	-1.4	-1.1	-1.0	-0.2	-1.2	-1.5	-1.1
Guilty feelings	0.4	0.6	1.2	0.7	-0.4	-0.9	1.1	0.2	-0.8	1.0
Wears glasses or contact lenses	0.2	0.2	0.7	0.6	0.3	-0.3	-0.1	0.3	-0.3	-0.8
Ever taken oral contraceptive pill	1.3	1.4	3.4	0.7	-0.3	-1.8	0.8	0.4	-1.8	1.4
Hearing aid user	0.9	1.1	2.0	-0.8	-1.4	-1.1	-0.5	-1.4	-0.9	-0.7
Mother’s age at death	3.1	3.9	6.7	1.7	2.2	2.6	1.5	2.3	1.7	1.5
Financial situation satisfaction	1.7	2.1	4.4	1.8	-1.0	-2.1	1.6	-0.4	-0.9	1.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.8	0.2	-1.5	-1.7	0.1	-1.1	0.1	0.6
Commuting to job workplace: Public transport	1.3	1.5	3.4	0.9	1.4	1.3	0.7	1.9	0.7	1.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.3	-0.7	-0.5	0.7	-0.6	-0.4	-0.3
Medication: Blood pressure	0.5	0.9	2.5	-1.0	1.2	1.6	-0.8	0.2	1.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.0	0.3	1.4	1.3	-0.2	0.8	1.0	0.4
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.9	1.3	-0.8	-1.5	1.5	-0.8	-0.9	1.7
High cholesterol (Self-reported)	2.6	4.7	8.4	-2.6	-1.6	-1.4	-2.5	-2.6	-0.1	-2.9
Medication: Bendroflumethiazide	0.2	0.4	1.1	0.2	1.1	0.9	0.3	0.8	0.2	0.1
Medication: Paracetamol	0.7	1.1	3.5	-0.9	1.2	1.9	-0.9	0.5	0.9	0.2
Medication: Lisinopril	0.7	1.0	2.4	0.5	1.5	1.6	0.1	0.8	1.0	0.5
Medication: Atorvastatin	1.4	1.7	4.8	0.5	2.2	1.3	-1.4	0.7	1.2	-1.0
Illnesses of father: High blood pressure	0.3	0.4	2.0	-0.6	0.2	0.4	-1.4	-0.2	0.6	0.1
Alcohol drinker status: Never	0.5	0.6	2.1	0.2	0.6	1.0	-0.5	0.5	1.4	0.5
Ever smoked	3.7	6.6	12.2	-3.1	-2.0	-1.7	-2.9	-2.5	-1.6	-3.5
Basal metabolic rate	0.5	2.9	8.3	0.4	-1.2	-1.2	2.9	-1.8	-2.3	-0.2
Leg fat percentage (left)	1.6	5.7	10.4	-0.3	-1.9	-2.7	2.1	-3.2	-3.0	-2.3
Arm fat-free mass (left)	0.8	4.1	8.0	-0.3	-1.9	-2.1	2.1	-2.6	-2.8	-1.3
Number of operations (self-reported)	0.5	0.7	2.6	-0.4	-0.3	-0.4	-1.0	-0.8	-0.5	-1.6
Average weekly beer plus cider intake	1.3	1.8	3.1	0.1	-1.7	-1.8	1.6	-1.7	-1.2	-0.0
Irritability	0.2	0.4	1.7	0.2	0.5	0.4	0.5	1.3	-0.2	0.7
Risk taking	0.1	0.2	0.6	0.8	0.2	-0.2	0.6	0.2	-0.3	-0.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.7	-0.1	0.8	1.3	-0.5	0.7	0.8	-1.1
Fractured/broken bones in last 5 years	0.8	1.0	3.3	-1.2	-0.4	-0.4	-1.0	-0.8	-0.6	-1.8
Age started oral contraceptive pill	0.2	0.3	0.8	-0.1	-0.2	0.8	0.4	0.1	0.9	0.8
Diastolic blood pressure, automated reading	0.2	0.5	2.1	0.1	-0.7	-0.5	0.5	-1.5	0.5	0.3
Ever depressed for a whole week	0.3	0.4	1.1	-0.6	-0.6	-0.0	-0.7	-0.6	-1.0	0.1
Unable to work because of sickness or disability	0.7	1.0	2.7	-1.6	-0.4	0.4	-0.4	-0.7	-0.9	-1.5
Commuting to job workplace: Cycle	0.3	0.3	0.7	-0.3	-0.6	-0.3	0.7	-0.8	-0.7	0.1
Myopia	5.9	8.5	13.3	3.2	3.1	2.4	0.0	3.6	2.8	3.6
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.5	1.1	-0.2	-0.4	0.8	1.4	-0.0	1.6
Cholesterol lowering medication	3.4	4.9	11.2	-1.9	-2.4	-2.7	-0.6	-3.3	-1.8	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.2	0.1	1.5	1.4	-0.5	0.2	0.9	-0.1
Pain experienced in last month	1.1	1.8	4.8	0.8	0.7	1.0	0.5	1.4	1.8	2.2
Supplements: Calcium	0.3	0.3	0.6	0.8	0.4	0.1	0.2	0.5	0.8	0.8
Basal cell carcinoma (self-reported)	1.7	2.0	4.3	-1.0	0.9	1.4	-2.1	1.3	2.0	0.6
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.6	-0.1	0.1	0.5	-0.4	-0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.1	0.1	0.2	0.3	0.1	0.3	0.2
Heart disease (siblings)	1.4	1.7	4.2	-1.9	-0.8	-0.1	-0.8	-1.1	-1.3	-2.0
Alcohol drinker status: Previous	0.7	0.7	2.1	-0.6	-0.3	-0.9	-1.4	-0.7	0.3	-1.1
Pack years of smoking	0.3	0.5	1.4	0.0	0.3	0.6	-0.4	-0.5	1.0	-1.2
Impedance of whole body	0.6	3.3	9.0	-2.8	0.3	1.4	-3.0	0.1	1.1	-1.8
Leg fat mass (left)	1.3	5.2	9.0	0.3	-1.6	-2.3	3.0	-2.9	-3.0	-1.6
Arm predicted mass (left)	0.8	4.1	7.9	-0.2	-1.8	-2.1	2.2	-2.6	-2.8	-1.2