TWAS hub - C1orf212

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0397	0.0169	1.8e-05	0.013	0.026	0.022	NA	0.020	7.1e-04	4.2e-06	2.2e-05	NA	5.3e-05
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0676	0.0287	8.7e-04	0.031	0.022	0.009	NA	0.009	1.9e-04	1.5e-03	3.1e-02	NA	2.7e-02
3	TCGA	Brain Lower Grade Glioma	0.0936	0.0453	1.7e-04	0.022	0.036	0.028	NA	0.038	1.2e-03	6.0e-05	3.1e-04	NA	3.8e-05
4	TCGA	Lung Adenocarcinoma	0.0848	0.0377	5.3e-03	-0.001	0.020	0.026	NA	0.004	5.3e-01	2.1e-03	4.4e-04	NA	1.0e-01
5	TCGA	Pancreatic Adenocarcinoma	0.2240	0.0970	9.0e-03	0.098	0.038	0.104	NA	0.081	6.7e-05	1.1e-02	4.1e-05	NA	2.9e-04
6	TCGA	Prostate Adenocarcinoma	0.1393	0.0409	7.9e-09	0.127	0.116	0.125	NA	0.127	3.2e-13	4.1e-12	5.3e-13	NA	3.4e-13
7	TCGA	Thyroid Carcinoma	0.1220	0.0380	1.1e-07	0.031	0.072	0.072	NA	0.079	5.0e-04	1.7e-07	1.5e-07	NA	4.0e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Falls in the last year	6.9	9.4	14.7	2.8	3.0	3.8	1.3	3.3	3.0	3.6
Pain all over the body in last month	5.2	5.6	9.4	2.2	1.6	3.1	1.1	2.5	2.9	2.5
Illness, injury, bereavement, stress in last 2 years	3.4	4.2	7.4	-1.4	-1.7	-2.7	-0.8	-2.3	-2.5	-2.1
Average weekly beer plus cider intake	3.1	4.5	8.2	2.7	2.0	1.8	1.2	2.2	1.7	2.9
Medication for hormone replacement therapy	2.8	3.1	5.7	-1.8	-0.7	-1.8	-1.3	-2.1	-1.6	-2.4
Length of working week for main job	2.7	2.9	5.5	-0.1	-2.4	-2.2	-0.5	-1.9	-2.0	-1.5
Fed-up feelings	2.5	4.5	6.5	-1.9	-2.2	-1.9	-2.1	-2.2	-1.9	-2.5
Systolic blood pressure, automated reading	2.4	7.1	16.6	4.1	0.9	2.9	2.7	1.8	2.3	2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	7.3	1.4	2.7	1.0	1.1	1.8	1.4	1.8
Hearing difficulty/problems: Yes	2.2	3.3	7.1	2.3	2.7	1.1	1.4	1.3	1.6	1.9
Loud music exposure frequency	2.2	2.4	4.4	1.2	1.0	1.4	2.1	1.7	1.7	1.5
Stomach or abdominal pain in last month	2.1	2.6	6.6	-1.6	-1.1	-1.3	-1.2	-1.9	-1.2	-2.6
Medication: Blood pressure	2.1	4.0	10.0	3.2	-0.0	2.8	1.7	1.2	1.8	1.7
Frequency of depressed mood in last 2 weeks	2.0	2.8	6.4	2.5	1.0	2.5	0.3	1.0	1.5	1.6
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	7.1	-1.8	-2.2	-2.7	-0.7	-2.1	-2.5	-2.3
Nervous feelings	1.9	3.6	4.7	-1.9	-2.1	-2.2	-1.9	-1.5	-1.7	-1.8
Diastolic blood pressure, automated reading	1.9	5.8	8.9	3.0	1.3	3.0	1.9	2.1	2.6	2.5
Knee pain experienced in last month	1.8	2.8	5.1	-1.3	-1.3	-1.6	-1.2	-2.0	-2.3	-1.7
Supplements: Glucosamine	1.7	2.2	5.6	-1.6	-1.6	-2.4	-0.1	-0.9	-1.5	-1.3
Hair/balding pattern: Pattern 2	1.7	2.1	4.7	-2.2	-1.5	-1.7	-0.3	-0.9	-1.0	-1.7
Systolic Blood Pressure	1.6	8.1	12.2	3.5	1.2	3.3	2.9	2.4	3.0	3.1
Illnesses of mother	1.5	1.9	2.5	1.6	1.3	1.4	1.4	1.4	1.2	1.3
Eye problems/disorders: Cataract	1.5	1.7	3.0	0.8	1.6	1.7	-0.9	1.2	1.3	1.5
Alcohol intake versus 10 years previously	1.4	2.0	4.6	0.6	-2.0	-0.5	-0.7	-2.1	-1.7	-1.3
Alcohol intake frequency.	1.4	3.3	10.4	-1.5	-3.2	-0.8	-2.0	-1.3	-1.2	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	3.2	-1.7	-0.5	-1.8	-0.2	-1.1	-1.3	-1.6
Commuting to job workplace: Cycle	1.4	1.7	3.7	0.9	1.9	1.5	-0.0	1.1	1.0	1.6
Sensitivity / hurt feelings	1.3	2.3	5.6	0.6	-1.4	-1.3	-0.6	-2.4	-1.8	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	5.0	-0.9	-1.7	-2.0	-0.2	-1.9	-2.2	-1.9
Long-standing illness, disability or infirmity	1.3	2.0	5.7	1.4	-0.2	2.4	0.9	1.1	1.6	1.2
Neuroticism (2016)	1.2	1.8	3.0	0.1	-1.7	-1.5	-0.9	-1.2	-1.7	-1.3
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.2	-1.8	-0.9	-1.4	-0.9	-1.0	-1.1	-1.4
Mouth/teeth dental problems: Dentures	1.2	2.0	5.0	0.2	-2.2	-1.1	-1.2	-1.4	-2.0	-0.7
Alcohol drinker status: Previous	1.2	1.4	7.5	-0.2	-1.1	0.2	-2.7	-0.4	-0.8	0.3
Alzheimer’s Disease (in mother)	1.1	1.3	2.1	-1.2	-0.3	-1.2	-1.2	-1.3	-0.8	-1.5
Age at First Birth	1.1	1.6	3.8	-0.5	-0.9	-1.3	-1.5	-1.4	-1.9	-0.5
Blood White Count	1.1	8.0	27.1	5.2	1.9	3.2	1.9	0.9	1.8	2.7
High blood pressure	1.1	3.1	5.8	2.4	-0.9	2.3	2.0	1.0	1.5	1.6
Neuroticism score	1.1	2.4	3.9	-0.9	-1.1	-1.7	-2.0	-1.7	-1.6	-1.7
Breastfed as a baby	1.1	1.4	5.3	-2.3	0.3	-1.4	-1.5	0.5	-0.2	-0.3
Hair/balding pattern: Pattern 4	1.1	2.8	4.8	1.9	2.2	1.6	0.6	1.5	1.5	1.9
Birth weight of first child	1.1	2.0	5.9	-1.4	-2.4	-1.0	-0.4	-1.1	-1.1	-1.5
Commuting to job workplace: Car/motor vehicle	1.1	1.2	5.6	0.7	-1.2	0.2	2.4	0.3	0.9	0.3
Commuting to job workplace: Walk	1.1	1.1	3.5	0.9	1.9	0.9	-0.2	0.9	1.1	1.0
Medication: Gliclazide	1.1	1.2	1.8	1.0	1.3	1.3	-0.1	1.3	0.9	1.2
Medication: Bendroflumethiazide	1.1	1.7	4.8	1.1	-2.2	0.1	1.7	-1.4	-0.5	-1.0
Waist Hip Ratio (WHR)	1.0	4.6	12.2	-0.9	-3.5	-1.8	-0.1	-2.4	-2.4	-2.1
Number of treatments/medications taken	1.0	1.8	3.3	1.6	-0.4	1.8	0.7	1.2	1.3	1.6
Average weekly fortified wine intake	1.0	1.2	2.6	0.7	1.6	0.8	1.1	1.1	1.1	1.0
Hearing difficulty/problems with background noise	1.0	1.6	3.2	1.6	1.8	0.7	1.4	0.7	1.1	1.1
Mouth/teeth dental problems	1.0	1.6	2.7	0.4	1.5	1.1	1.3	1.5	1.6	0.9
Fluid intelligence score	1.0	2.0	3.1	-0.9	-0.3	-1.6	-1.8	-1.6	-1.8	-1.4
Medication: Amlodipine	1.0	1.3	2.1	0.7	1.2	1.4	0.5	1.3	1.2	1.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.1	-0.9	-1.8	-0.4	-0.7	-1.3	-1.0	-1.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.9	1.1	0.3	0.5	2.2	0.8	0.8	0.9
Supplements: Fish oil (including cod liver oil)	1.0	1.2	4.5	-0.4	-0.8	-2.1	0.3	-0.9	-1.2	-1.1
Vascular/heart problems diagnosed by doctor	1.0	2.8	5.9	-2.4	0.9	-2.0	-1.9	-0.9	-1.3	-1.6
Alzheimer’s Disease (including proxy)	0.9	1.3	2.7	-1.2	0.1	-0.7	-1.5	-1.4	-0.6	-1.6
Ovarian Cancer	0.9	1.2	2.5	1.0	0.8	1.6	1.1	0.9	1.3	0.9
Medication: Simvastatin	0.9	1.3	4.2	0.5	-2.0	-1.1	0.4	-1.1	-1.4	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.2	-0.4	0.3	0.4	1.8	1.1	1.3	0.4
Comparative body size at age 10	0.9	2.4	5.7	2.4	1.4	1.1	2.4	0.6	1.0	1.0
Medication: Seretide 50 evohaler	0.9	1.1	3.3	-1.3	-1.8	-0.9	-0.4	-0.4	-1.1	-0.4
Overall health rating	0.9	1.9	5.4	1.8	0.6	2.3	0.3	0.9	1.3	1.4
Average weekly red wine intake	0.9	1.3	2.8	-0.7	0.6	-1.4	-1.7	-0.9	-1.7	-0.4
Mineral and other dietary supplements	0.9	1.2	4.1	0.4	0.8	2.0	-0.6	0.9	1.1	1.0
Number of operations (self-reported)	0.9	1.3	4.8	0.8	0.2	2.2	-0.1	0.9	1.3	0.9
Reaction Time	0.8	1.5	5.1	-0.5	0.9	1.3	-2.2	1.0	0.7	1.1
Prostate Cancer	0.8	1.2	2.1	1.4	1.1	1.2	1.0	0.6	1.2	0.7
Lupus	0.8	1.2	2.3	1.5	0.6	1.3	1.3	0.7	0.9	1.1
Qualifications: CSEs or equivalent	0.8	1.0	3.3	0.5	1.8	0.1	1.2	0.9	1.0	0.5
Serious illness, injury or assault to yourself	0.8	0.9	2.1	-0.1	0.6	0.9	-0.7	1.5	0.9	1.4
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.3	-1.8	-1.1	-0.9	-1.1	0.1	-0.5	-0.5
Pulse wave peak to peak time	0.8	0.9	3.4	-0.7	-0.7	-1.8	-0.2	-0.7	-1.2	-0.4
Medication: Ibuprofen	0.8	1.0	1.4	0.8	1.2	1.1	-0.0	1.0	1.1	1.1
Ever had bowel cancer screening	0.8	1.0	2.7	-1.0	-0.5	-0.6	-1.6	-0.6	-1.3	-0.7
Medication for cholesterol	0.8	1.2	5.0	-2.2	0.2	-1.5	-0.9	0.0	-0.8	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	4.0	2.0	-0.6	1.0	0.5	-0.1	0.0	0.8
Age started oral contraceptive pill	0.8	1.1	2.2	0.9	-0.2	0.9	1.5	0.8	1.3	1.1
Cholesterol lowering medication	0.8	1.1	3.3	1.8	-1.8	0.1	0.2	-0.9	-0.8	-0.1
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.4	-1.8	-0.2	-1.6	-2.1	-1.2	-1.6	-1.1
Fasting Glucose	0.7	0.8	1.3	0.6	0.9	0.9	1.0	0.8	1.1	0.7
HDL Cholesterol	0.7	1.2	2.4	0.3	0.5	0.8	1.5	1.2	1.5	1.0
Hayfever, allergic rhinitis or eczema	0.7	1.5	5.0	-2.2	0.9	-0.4	-2.0	0.1	0.5	-0.1
High blood pressure (mother)	0.7	0.9	2.0	0.1	1.0	0.9	0.1	1.4	1.3	1.1
Financial difficulties in last 2 years	0.7	1.0	3.1	1.6	0.8	1.8	0.1	0.0	0.7	0.2
Time employed in main current job	0.7	0.8	3.9	-0.8	-2.0	-0.2	0.8	-0.2	-0.3	-0.4
Exposure to tobacco smoke at home	0.7	0.8	1.6	-0.1	1.1	1.3	0.1	0.9	1.2	0.5
Gout (self-reported)	0.7	0.9	1.9	0.1	0.9	0.4	1.4	1.3	1.2	0.8
Worry too long after embarrassment	0.7	1.2	2.0	-1.3	-1.2	-1.3	-0.5	-0.7	-0.7	-1.4
Hypertension (Self-reported)	0.7	2.1	3.7	1.9	-0.7	1.9	1.9	0.7	1.1	1.1
Smoking status: Previous	0.7	1.0	3.8	0.1	-1.0	-1.3	0.0	-0.7	-2.0	-0.3
Medication: Paracetamol	0.7	1.2	2.5	1.1	0.1	1.6	0.3	1.2	1.3	1.1
Myopia	0.7	1.0	5.2	-0.1	2.3	0.8	-0.0	0.7	0.8	0.6
Crohns Disease (2017)	0.6	1.3	5.8	-0.5	-2.4	-0.6	0.6	-0.9	-0.6	-1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.9	-0.4	0.1	-1.0	-2.0	-1.3	-1.6	-0.7
Primary Biliary Cirrhosis	0.6	0.8	1.8	-0.4	-0.9	-0.3	-0.5	-1.3	-1.0	-1.2
Allergy or Eczema	0.6	1.6	6.2	-2.5	-0.6	-1.1	-1.4	-0.7	-0.3	-1.0
Hand grip strength (left)	0.6	1.5	3.6	1.2	1.9	1.0	1.4	0.7	1.3	1.0
Medication: Co-codamol	0.6	0.7	2.4	0.6	0.1	1.5	0.4	0.8	0.8	0.9
Diabetes (mother)	0.6	0.8	1.6	-1.2	-0.8	-0.7	-0.4	-0.9	-0.4	-1.3
Relative age voice broke	0.6	0.9	3.4	0.6	-0.1	1.8	-0.7	0.9	0.8	0.9
Pulse wave Arterial Stiffness index	0.6	0.7	3.0	0.7	0.6	1.7	0.1	0.5	1.0	0.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.6	0.3	1.1	0.8	0.9	1.2	0.9	1.3
Blood clot in the leg (DVT)	0.6	0.8	2.9	1.1	1.7	0.5	-0.8	-0.0	0.4	0.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	-0.2	-1.3	-0.6	-0.2	-1.3	-0.7	-1.0
High blood pressure (siblings)	0.6	0.8	1.8	0.3	-0.5	0.8	-0.2	1.4	0.9	1.3
Exposure to tobacco smoke outside home	0.6	0.7	2.6	0.7	1.6	1.0	0.1	0.5	0.8	0.3
Medication for pain relief, constipation, heartburn	0.6	1.1	3.1	-1.8	-0.8	-1.1	0.6	-0.6	-0.3	-1.3
Medication: Blood pressure	0.6	1.0	2.3	-0.9	-1.5	-1.4	0.3	-0.6	-1.1	-0.6
Back pain experienced in last month	0.6	0.9	3.0	-0.0	-0.7	-0.0	-0.6	-1.7	-1.0	-1.1
Osteoporosis (self-reported)	0.6	0.7	2.8	0.9	-0.3	0.5	-1.7	-0.2	-0.6	1.0
Average weekly champagne plus white wine intake	0.6	0.8	2.5	0.9	1.6	0.6	-1.2	-0.0	0.2	0.5
Illnesses of father: High blood pressure	0.6	0.8	2.0	0.9	0.0	1.3	0.2	0.7	0.6	1.4
Supplements: Calcium	0.6	0.6	1.4	-1.2	-1.1	-0.3	-0.6	-0.2	-0.8	-0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	6.3	-0.1	2.5	0.0	0.1	1.0	0.8	0.6
Depressed Affect (Nagel 2018)	0.5	1.0	2.3	0.6	-0.4	-0.6	-1.0	-1.5	-1.4	-1.0
Irritable Bowel Disease (IBD)	0.5	1.2	5.4	-0.5	-2.3	-0.6	0.1	-0.8	-0.7	-1.0
Ulcerative Colitis (UC)	0.5	0.9	2.2	-1.0	-1.5	-0.8	-0.6	-0.6	-0.8	-0.9
HbA1C	0.5	0.6	1.4	1.2	0.9	0.6	-0.3	0.3	0.7	0.9
Blood Platelet Count	0.5	5.4	11.2	3.4	1.9	3.3	-0.3	1.4	2.2	2.3
Respiratory disease	0.5	1.2	2.6	-1.1	-1.6	-1.4	-0.3	-0.9	-0.7	-1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.0	-0.2	-1.0	1.4	-1.1	0.1	0.6	0.0
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.9	-0.2	-0.8	-0.3	-1.4	-0.7	-0.6	-0.1
Supplements: Zinc	0.5	0.5	1.7	-0.4	-0.5	0.2	1.3	-0.1	0.3	-1.1
Medication: Metformin	0.5	0.7	1.5	0.1	-0.9	-0.4	-1.2	-0.8	-1.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.9	-1.1	-1.4	-0.6	-0.4	-0.4	-0.2	-0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.6	-1.3	-1.0	-0.4	0.5	-0.1	0.2	-0.7
Multivitamins +/- minerals	0.5	0.6	1.9	-1.4	1.1	-0.3	-0.8	0.3	-0.1	-0.3
Waist circumference	0.5	1.9	6.4	0.8	-2.5	-0.5	-0.4	-1.6	-1.6	-1.0
Heart attack	0.5	0.6	1.8	1.3	-0.7	0.3	1.1	0.4	0.2	0.8
Prospective memory result	0.5	0.6	1.7	-0.1	-0.7	-0.7	-1.0	-0.5	-1.3	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.1	0.8	2.0	1.4	0.3	1.4	1.5	1.0
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.6	-0.5	0.6	1.0	-0.5	0.6	1.2	0.2
Birth weight	0.5	1.1	2.1	0.7	-1.5	-0.9	1.2	-1.3	-0.3	-0.8
Leg fat percentage (right)	0.5	1.6	4.8	0.5	-2.2	-0.3	-0.7	-1.6	-1.4	-1.2
Health satisfaction	0.5	0.6	2.2	0.6	0.5	1.5	0.1	0.3	1.0	0.7
Mean time to correctly identify matches	0.5	1.0	3.1	0.1	0.2	1.8	-1.2	0.9	0.9	0.9
Supplements: Vitamin C	0.5	0.6	2.3	0.7	-1.0	-0.6	1.5	-0.3	-0.3	-0.4
Illnesses of siblings: Diabetes	0.5	0.6	1.2	0.3	-0.2	0.9	1.1	0.9	1.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.3	-0.7	0.9	-0.9	-2.1	-0.3	-0.6	-0.2
Loneliness, isolation	0.5	0.7	1.9	1.0	1.4	0.0	-1.3	-0.4	-0.3	0.1
Number of self-reported non-cancer illnesses	0.5	0.9	2.0	0.7	-0.8	1.4	0.7	0.6	1.2	0.8
Guilty feelings	0.5	0.8	1.6	0.8	-0.6	-1.0	0.4	-1.2	-0.7	-1.0
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	1.0	0.6	0.4	0.5	0.8	0.6	1.2
Fractured/broken bones in last 5 years	0.5	0.6	1.5	0.1	-0.1	1.1	0.0	1.2	0.8	1.0
Unable to work because of sickness or disability	0.5	0.7	1.4	0.8	-0.7	1.2	-1.0	0.5	0.3	1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.3	1.2	1.5	0.4	-0.7	-0.1	0.3	0.6
Neuroticism (Nagel 2018)	0.4	0.8	1.9	0.1	-0.4	-0.7	-1.4	-1.2	-0.9	-0.9
Schizophrenia (2018)	0.4	0.8	4.9	0.7	2.2	0.2	0.3	0.2	0.5	0.2
Blood Eosinophil Count	0.4	3.0	5.2	1.9	2.3	2.2	0.4	0.9	2.2	1.3
Average weekly spirits intake	0.4	0.5	2.0	-0.9	-0.2	-0.0	-1.4	-0.2	-0.6	-0.5
Ever had hysterectomy (womb removed)	0.4	0.5	2.1	-0.3	-0.6	-0.1	-1.4	-0.7	-0.4	-0.4
Angina	0.4	0.5	1.0	1.0	-0.4	0.5	-1.0	0.0	-0.5	0.9
Trunk fat percentage	0.4	1.5	3.5	1.4	-1.4	-0.3	-0.3	-1.9	-1.5	-1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	2.2	-0.1	-0.2	-0.0	-1.5	-0.6	-0.7	0.0
Medication: Atenolol	0.4	0.5	0.9	1.0	-1.0	-0.0	0.8	0.1	-0.4	0.8
Medication: Levothyroxine sodium	0.4	0.6	2.2	0.7	-1.2	0.3	1.5	0.0	0.1	-0.1
Trunk fat mass	0.4	1.6	3.6	1.1	-1.5	-0.3	-0.5	-1.9	-1.6	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	-0.1	-1.2	-0.3	-0.8	-0.8	-0.7	-0.8
Medication: Ramipril	0.4	0.6	1.6	1.3	-0.8	-0.0	0.6	-0.8	-0.6	-0.5
Father’s age at death	0.4	0.6	1.3	0.3	1.0	1.2	-0.3	0.8	0.9	0.5
Worrier / anxious feelings	0.4	0.8	3.9	-1.2	-0.0	-0.6	-2.0	0.4	-0.3	0.1
Happiness	0.4	0.5	1.2	-0.4	0.6	-0.2	-1.1	-1.0	-0.4	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.9	0.5	1.4	0.5	-0.9	-0.0	0.4	0.5
Medication: Lansoprazole	0.4	0.5	1.7	0.2	0.7	0.4	-1.3	0.5	0.5	0.8
Lung cancer (father)	0.4	0.5	0.8	-0.4	-0.6	-0.8	-0.7	-0.9	-0.6	-0.8
Pulse wave reflection index	0.4	0.5	1.3	0.2	-0.6	0.7	1.2	0.8	0.7	0.2
Glaucoma (self-reported)	0.4	0.5	1.9	0.2	-0.0	1.4	0.3	0.3	1.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.9	-0.1	-1.7	-0.6	0.5	-0.9	-1.0	-0.8
Body fat percentage	0.4	1.6	3.4	1.1	-1.8	-0.4	-0.5	-1.8	-1.5	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	0.5	1.1	1.0	-0.6	0.4	0.7	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.8	1.4	0.2	1.1	0.6	0.2	0.3	0.4
Age at first live birth	0.4	0.7	2.6	0.5	1.6	0.7	-0.6	0.5	0.3	0.8
Eye problems/disorders: None of the above	0.4	0.4	1.5	-0.3	0.1	-1.2	0.1	-0.3	-1.0	-0.5
Emphysema/chronic bronchitis	0.4	0.4	1.0	-0.1	-1.0	0.3	-0.9	-0.7	-0.5	-0.6
Angina (self-reported)	0.4	0.5	1.1	1.1	-0.5	0.4	-0.9	-0.1	-0.6	0.8
Leg fat mass (right)	0.4	1.4	3.8	0.5	-1.9	-0.3	-0.6	-1.5	-1.4	-1.0
Number of full sisters	0.4	0.5	1.5	-0.7	-0.3	0.3	-1.2	0.9	0.5	0.5
Had major operations	0.4	0.5	1.1	0.7	0.1	-0.2	-1.0	-1.1	-0.7	-0.3
Age at last live birth	0.4	0.6	1.6	0.4	0.9	1.3	-0.1	0.8	0.6	0.8
Family relationship satisfaction	0.4	0.5	1.3	0.7	0.5	0.3	-0.7	-1.1	-0.2	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.7	-1.0	-0.5	-0.0	-1.3	-0.3	-0.1	-0.4
Illnesses of father: Heart disease	0.4	0.5	2.5	0.4	-0.6	-0.3	1.6	-0.4	0.2	-0.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	-0.1	1.0	0.0	0.0	1.0	0.7	0.9
Commuting to job workplace: Public transport	0.4	0.5	2.2	0.2	1.5	-0.1	-1.0	-0.4	-0.2	-0.3
Eye problems/disorders: Glaucoma	0.4	0.4	1.8	-0.1	0.1	1.3	0.1	0.2	1.1	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	0.8	-0.1	1.2	1.0	0.1	0.5	0.3
Ever smoked	0.4	0.7	2.1	1.1	1.4	0.1	1.0	0.4	-0.2	0.7
Risk taking	0.4	0.6	2.6	0.6	1.6	0.7	-0.4	0.1	0.7	0.0
Heart disease (siblings)	0.4	0.5	1.1	0.5	1.1	0.8	0.1	0.7	0.8	0.5
Pack years of smoking	0.4	0.6	2.3	-1.0	-1.5	0.1	-0.8	-0.1	-0.1	-0.3
Bipolar Disorder (2018)	0.3	0.5	2.2	-1.5	1.0	0.0	0.0	0.0	0.0	-0.5
Depression (Nagel 2018)	0.3	0.5	1.1	1.0	0.3	1.1	-0.8	0.0	0.1	0.6
Alzheimer’s Disease (in father)	0.3	0.3	1.2	-0.0	0.4	0.5	-1.1	-0.5	0.2	-0.7
Breast Cancer	0.3	0.7	2.0	-1.4	0.2	-1.1	1.0	0.5	-0.1	-0.3
Mean Putamen Volume	0.3	0.3	0.7	-0.5	0.5	-0.2	0.6	0.8	0.8	0.4
Cardiovascular Disease	0.3	1.1	2.2	1.1	-0.1	1.5	1.3	0.6	1.4	0.8
Hypothyroidism (self reported)	0.3	0.6	2.2	-0.5	-1.5	-0.7	0.4	-0.5	-0.8	-0.6
Relative age of first facial hair	0.3	0.7	1.4	-0.6	0.5	1.2	-1.1	0.7	1.1	0.3
Vitamin and mineral supplements	0.3	0.4	0.8	0.5	0.0	0.8	0.5	0.5	0.9	0.6
Severe depression (siblings)	0.3	0.4	1.8	1.3	0.2	0.4	0.3	-0.0	0.5	0.3
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	-0.2	-0.9	-0.5	-0.6	-0.4	-0.5	-0.6
Past tobacco smoking	0.3	0.6	2.6	-0.2	0.1	1.0	0.0	0.5	1.6	0.2
Alcohol usually taken with meals	0.3	0.5	1.1	-0.9	-0.6	-0.8	0.1	-0.7	-1.0	-0.6
Had menopause	0.3	0.4	1.5	-0.4	-0.8	0.0	1.2	0.6	0.2	0.1
Qualifications: None of the above	0.3	0.6	1.1	0.3	-1.0	-0.7	-0.0	-1.1	-1.0	-0.8
Allergy	0.3	0.6	1.9	1.4	-0.6	0.5	1.2	0.2	-0.5	0.1
Diabetes (self-reported)	0.3	0.5	1.0	-0.5	-0.4	-1.0	-0.5	-0.8	-0.9	-0.7
Arm fat percentage (right)	0.3	1.1	3.1	1.8	-1.4	0.3	0.5	-1.2	-0.6	-0.5
Pulse rate	0.3	0.4	1.1	0.9	0.9	1.1	-0.3	-0.1	0.4	0.3
Noisy workplace	0.3	0.4	1.0	0.8	0.2	0.2	-1.0	0.5	-0.2	0.8
Medication: Cholesterol lowering	0.3	0.5	2.5	0.9	-0.5	-0.4	1.6	-0.1	-0.2	-0.1
Tense / ‘highly strung’	0.3	0.5	1.5	1.2	0.8	0.3	0.0	0.4	0.7	0.6
Medication: Paracetamol	0.3	0.6	1.4	1.1	-0.1	1.2	-0.3	0.5	0.4	0.9
Headache pain in last month	0.3	0.6	1.3	-0.1	-1.1	0.0	1.1	-0.7	-0.3	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.1	3.6	0.6	1.9	0.9	-0.0	1.1	1.0	0.8
Number of children fathered	0.3	0.3	1.6	0.4	-1.3	-0.3	0.4	-0.3	-0.5	0.0
Pulse rate, automated reading	0.3	1.0	2.0	0.4	-1.4	-0.6	-1.0	-1.2	-1.3	-0.3
Suffer from ‘nerves’	0.3	0.4	1.6	0.8	-0.5	0.6	-1.3	-0.2	0.1	0.1
Leg pain on walking	0.3	0.3	0.9	1.0	-0.5	0.9	-0.1	-0.4	0.1	-0.0
Arm fat percentage (left)	0.3	1.2	3.0	1.5	-1.7	0.1	0.2	-1.4	-0.8	-0.7
Mood swings	0.3	0.6	1.7	-0.4	-0.9	-0.7	-1.3	-0.6	-0.7	-0.6
Breast cancer (self-reported)	0.3	0.3	1.6	-0.6	-1.3	-0.2	-0.5	0.1	-0.3	0.1
Financial situation satisfaction	0.3	0.4	1.0	0.6	0.5	1.0	0.3	0.5	0.8	0.5
Medication: Lisinopril	0.3	0.4	1.3	-0.2	-1.1	0.1	-1.1	0.0	-0.4	0.3
Leg fat percentage (left)	0.3	1.1	3.1	0.9	-1.8	-0.0	-0.3	-1.3	-1.1	-0.9
Irritability	0.3	0.5	1.5	-0.8	-0.4	-1.0	-1.2	-0.1	-0.3	-0.2
Ever depressed for a whole week	0.3	0.4	1.4	0.0	1.2	0.6	0.1	0.4	0.8	0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.4	0.4	0.1	0.7	-1.2	-0.1	-0.2	0.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	-0.5	0.6	-0.5	0.0	-0.8	-0.2	-0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	1.1	-0.9	0.1	0.8	0.1	-0.0	0.6
Leg fat mass (left)	0.3	1.0	2.5	0.7	-1.6	-0.2	-0.4	-1.4	-1.2	-0.8
Worry (Nagel 2018)	0.2	0.4	2.5	-0.0	-0.3	-0.1	-1.6	-0.3	-0.3	-0.1
Schizophrenia (2014)	0.2	0.5	3.0	-0.2	1.7	-0.3	-0.0	0.3	0.1	0.2
Smoking Status	0.2	0.5	1.3	0.3	-0.0	-1.1	0.4	-0.6	-1.1	-0.1
Lung FEV1/FVC ratio	0.2	0.8	1.4	1.1	1.0	1.2	0.8	0.7	0.9	0.4
Lung FVC	0.2	0.9	3.0	-0.0	1.7	0.9	-0.4	1.3	0.7	0.6
Neuroticism	0.2	0.6	1.4	-0.1	-0.3	-0.8	-1.2	-0.9	-0.7	-0.8
Chronotype (morning person)	0.2	0.6	2.5	0.7	1.6	0.3	0.1	0.6	0.7	0.1
Diabetes (father)	0.2	0.3	0.7	0.5	0.8	-0.2	0.8	-0.2	0.4	-0.5
Pack years adult smoking proportion	0.2	0.3	1.3	-0.7	-1.1	0.4	-0.6	0.2	0.1	-0.0
Maternal smoking around birth	0.2	0.3	0.8	-0.7	-0.4	-0.4	-0.3	-0.4	0.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.2	1.1	0.5	0.5	-0.5	0.2	-0.1	0.5
Taking other prescription medications	0.2	0.3	0.8	0.7	-0.8	0.9	0.0	-0.2	0.0	0.1
Age when periods started (menarche)	0.2	0.4	1.2	-1.1	0.2	-0.3	-0.8	0.8	0.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.2	-1.1	0.9	-0.2	-0.2	0.1	0.5	-0.1
Illnesses of siblings	0.2	0.3	0.8	0.6	0.9	-0.1	-0.1	-0.7	-0.7	-0.2
Weight	0.2	0.8	2.0	0.6	-1.1	-0.2	-0.6	-1.4	-1.1	-0.8
Impedance of arm (right)	0.2	0.7	1.6	1.3	-0.7	-0.5	1.0	-1.1	-0.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	-0.7	-0.5	0.5	-0.0	0.5	0.8	0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.5	0.9	-0.5	-0.7	0.2	-0.0	0.0
Depression (self-reported)	0.2	0.2	0.8	-0.3	0.2	-0.4	-0.9	-0.6	-0.5	-0.2
Impedance of arm (left)	0.2	0.8	1.6	0.8	-1.0	-0.7	0.6	-1.3	-1.0	-0.6
Arm fat mass (right)	0.2	0.8	1.8	1.1	-1.4	0.0	0.1	-1.2	-0.8	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.1	0.8	0.7	-0.6	0.4	0.7	0.2
Arm fat-free mass (right)	0.2	1.0	2.2	-1.0	-0.0	-0.7	-1.5	-1.0	-1.2	-0.9
Number of full brothers	0.2	0.2	0.5	-0.7	0.3	-0.1	-0.6	0.7	0.5	-0.2
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	0.2	0.0	1.1	-0.0	0.4	1.0	0.7
Qualifications: College or University degree	0.2	0.8	2.2	-1.5	-1.0	-0.8	-0.7	-0.4	-0.6	-0.6
Medication: Allopurinol	0.2	0.2	0.5	0.0	0.3	0.2	0.6	0.7	0.6	0.3
Heart disease (mother)	0.2	0.2	0.5	-0.1	-0.2	-0.6	-0.7	0.4	-0.4	0.5
Whole body fat mass	0.2	1.0	2.1	1.1	-1.4	-0.0	-0.4	-1.4	-1.1	-0.8
Comparative height size at age 10	0.2	1.0	2.1	0.1	0.1	-1.1	-1.1	-1.4	-1.5	-0.8
Chest pain or discomfort	0.2	0.3	0.4	-0.3	-0.3	0.7	-0.6	0.5	0.6	0.5
Medication: Aspirin	0.2	0.2	0.8	0.9	0.4	-0.0	0.1	0.2	-0.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.8	0.3	0.1	-0.3	-0.5	-0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	0.9	0.2	0.8	-0.7	-0.3	-0.2	0.3
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.3	-0.6	0.7	-0.3	0.6	0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	-0.1	0.7	0.9	0.6	0.9	0.8	0.2
Arm fat mass (left)	0.2	0.9	2.2	1.0	-1.5	0.0	-0.0	-1.3	-0.9	-0.7
Wears glasses or contact lenses	0.2	0.2	0.8	0.9	-0.2	-0.0	-0.3	-0.4	-0.4	0.3
Mother’s age at death	0.2	0.2	0.5	0.7	-0.5	0.6	0.4	-0.2	-0.1	0.6
High cholesterol (Self-reported)	0.2	0.3	1.5	1.2	-0.6	0.6	0.0	-0.1	-0.0	0.4
Medication: Atorvastatin	0.2	0.3	0.7	0.2	-0.8	-0.4	-0.2	-0.4	-0.7	-0.4
Alcohol drinker status: Never	0.2	0.2	0.6	-0.8	-0.5	-0.7	-0.2	0.2	-0.1	0.2
Pain experienced in last month	0.2	0.3	1.2	0.1	0.3	-0.1	-0.2	1.1	0.5	0.8
Major Depression (MDD)	0.1	0.1	0.2	-0.1	0.5	0.4	-0.2	-0.3	0.0	-0.1
Rheumatoid Arthritis	0.1	0.1	0.3	0.1	-0.4	-0.3	0.6	-0.2	-0.2	0.0
Ulcerative Colitis	0.1	0.2	0.6	0.1	-0.3	0.0	0.0	0.6	0.7	0.3
Blood Red Count	0.1	1.1	2.7	-1.0	-1.4	-0.2	-1.6	-0.7	-0.9	-0.8
Heel T-Score	0.1	0.7	1.9	1.2	-0.2	0.7	1.4	0.4	0.4	0.7
Height	0.1	2.2	5.1	-0.1	-0.3	-1.6	-1.8	-2.0	-2.3	-0.9
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	-0.4	-0.5	-0.6	-0.5	-0.5	-0.5	-0.4
Hair Pigment	0.1	2.1	3.2	1.6	0.5	1.0	1.5	1.6	1.8	1.6
Tanning	0.1	0.8	2.3	-0.7	-0.2	-0.9	-1.5	-0.9	-1.1	-0.6
Impedance of leg (right)	0.1	0.4	1.0	-0.2	-0.3	-1.0	-0.3	-0.6	-0.9	-0.6
Leg fat-free mass (left)	0.1	0.6	1.4	-0.2	-0.6	-0.4	-0.8	-1.2	-1.1	-0.7
Hand grip strength (right)	0.1	0.2	1.0	0.4	1.0	-0.4	0.2	-0.4	-0.2	-0.0
Townsend deprivation index at recruitment	0.1	0.1	0.5	-0.4	0.4	-0.0	-0.7	0.2	0.2	-0.1
Current tobacco smoking	0.1	0.2	0.5	-0.5	0.6	-0.0	-0.7	0.1	0.2	-0.0
Sitting height	0.1	0.5	1.7	-0.0	-0.9	-0.5	-0.5	-0.8	-1.3	-0.1
Body mass index (BMI)	0.1	0.4	1.3	0.8	-1.1	0.3	-0.2	-0.7	-0.4	-0.3
Leg predicted mass (left)	0.1	0.6	1.4	-0.1	-0.6	-0.4	-0.8	-1.2	-1.0	-0.7
Number of incorrect matches in round	0.1	0.2	1.0	-0.7	-1.0	0.0	-0.3	0.2	0.1	-0.2
Had other major operations	0.1	0.2	0.5	0.1	-0.5	0.7	-0.4	-0.4	-0.3	-0.3
Forced vital capacity (FVC)	0.1	0.3	0.8	-0.8	0.9	-0.2	-0.5	0.2	-0.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	0.4	0.3	0.5	0.1	0.2	0.6	0.3
Trunk fat-free mass	0.1	0.5	0.8	-0.7	-0.5	-0.5	-0.7	-0.7	-0.9	-0.6
Hip circumference	0.1	0.6	1.5	1.2	-0.6	0.3	-0.8	-1.0	-0.6	-0.3
Number of live births	0.1	0.1	0.5	0.4	0.0	0.7	0.4	0.2	0.1	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.9	-0.2	1.0	0.4	-0.1	0.4	0.2	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	-0.2	0.5	-0.0	-0.1	-0.6	-0.1	-0.3
Asthma	0.1	0.1	0.4	-0.6	-0.4	-0.4	-0.2	0.1	0.3	0.1
Trunk predicted mass	0.1	0.4	0.7	-0.7	-0.5	-0.5	-0.7	-0.7	-0.8	-0.6
Standing height	0.1	1.2	3.1	-0.2	-0.2	-1.1	-0.9	-1.6	-1.8	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.6	0.1	0.8	0.4	-0.1	-0.0	0.2	-0.2
Peak expiratory flow (PEF)	0.1	0.3	0.4	0.2	0.5	0.6	-0.6	0.6	0.3	0.6
Shortness of breath walking on level ground	0.1	0.2	0.7	0.2	0.3	0.8	-0.3	-0.1	0.4	0.2
Migraine (self-reported)	0.1	0.2	0.4	0.2	-0.6	0.1	0.5	-0.3	-0.6	-0.3
Medication: Omeprazole	0.1	0.1	0.2	0.4	-0.4	0.2	-0.5	-0.4	-0.4	-0.1
Arm predicted mass (right)	0.1	0.7	1.8	-0.7	0.2	-0.5	-1.3	-0.9	-1.1	-0.6
Whole body fat-free mass	0.1	0.5	1.0	-0.4	-0.3	-0.4	-0.9	-0.9	-1.0	-0.6
Leg fat-free mass (right)	0.1	0.3	0.9	0.1	-0.2	-0.2	-0.6	-0.9	-0.8	-0.4
Diabetes diagnosed by doctor	0.1	0.2	0.8	-0.0	-0.1	-0.4	-0.9	-0.3	-0.6	-0.2
Friendships satisfaction	0.1	0.1	0.4	0.5	0.1	0.3	-0.1	-0.7	-0.0	-0.3
Qualifications: nursing, teaching	0.1	0.2	0.9	-0.9	-0.0	-0.1	-0.7	-0.1	0.1	-0.3
Asthma (self-reported)	0.1	0.1	0.3	-0.4	0.1	-0.2	0.2	0.4	0.5	0.4
Medication: Aspirin	0.1	0.1	0.2	0.5	0.0	-0.4	0.1	0.0	-0.4	0.3
Smoking status: Current	0.1	0.2	0.8	-0.5	0.9	-0.1	-0.6	0.1	0.2	-0.1
Whole body water mass	0.1	0.4	0.8	-0.3	-0.2	-0.3	-0.9	-0.8	-0.9	-0.5
Leg predicted mass (right)	0.1	0.3	0.8	0.0	-0.2	-0.2	-0.7	-0.9	-0.8	-0.4
Miserableness	0.1	0.2	0.5	0.6	0.1	0.0	0.4	-0.7	0.1	-0.5
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.3	0.0	-0.2	0.4	0.6	0.4	0.2
Hearing aid user	0.1	0.1	0.6	0.0	-0.1	0.4	-0.8	-0.1	0.0	0.4
Basal metabolic rate	0.1	0.5	1.2	-0.1	-0.4	-0.3	-0.7	-1.1	-1.0	-0.7
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.5	0.6	0.1	0.7	0.5	0.1	0.1	0.3
Arm predicted mass (left)	0.1	0.4	1.2	-0.3	0.1	-0.3	-1.1	-0.7	-0.8	-0.5
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.0	0.2	0.4	0.5	-0.6	0.2	-0.4	-0.6	-0.3	-0.2
Impedance of leg (left)	0.0	0.1	0.4	0.6	0.4	-0.3	0.3	-0.1	-0.4	-0.0
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.2	0.1	-0.1	-0.3	0.2	0.1	0.4
Neck or shoulder pain in last month	0.0	0.1	0.3	-0.3	-0.0	0.1	0.5	-0.1	0.3	0.0
Arm fat-free mass (left)	0.0	0.2	0.5	-0.2	0.2	-0.2	-0.7	-0.5	-0.6	-0.4
Impedance of whole body	0.0	0.2	0.7	0.9	0.1	-0.4	0.3	-0.6	-0.6	-0.2

Hub : Genes

C1orf212

Models

Trait associations