Hub : Genes

C1orf95

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0860	0.0350	2.1e-04	0.010	0.027	0.049	0.034	0.036	2.0e-02	3.0e-04	1.3e-06	5.3e-05	2.7e-05
2	GTEx	Nerve Tibial	0.4494	0.0572	1.8e-15	0.330	NA	0.329	NA	0.325	5.4e-24	NA	6.4e-24	NA	1.4e-23
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1170	0.0580	3.6e-03	0.106	0.034	0.068	NA	0.086	1.2e-06	5.0e-03	9.9e-05	NA	1.2e-05
4	TCGA	Brain Lower Grade Glioma	0.1113	0.0368	1.0e-05	0.059	0.051	0.059	NA	0.059	2.6e-07	1.7e-06	2.6e-07	NA	2.6e-07
5	TCGA	Prostate Adenocarcinoma	0.0595	0.0241	4.6e-04	0.015	0.021	0.002	NA	0.010	1.0e-02	2.8e-03	1.8e-01	NA	2.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.5	2.4	4.0	2.0	-1.7	1.9	-1.3	0.1
Bipolar Disorder or Schizophrenia	1.9	4.5	15.0	1.3	-1.9	3.9	-1.2	0.9
Depressed Affect (Nagel 2018)	0.3	0.6	1.2	0.5	0.9	0.8	1.1	-0.5
Depression (Nagel 2018)	0.3	0.5	1.7	0.3	0.6	1.3	-0.4	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.4	6.6	-0.4	2.6	0.1	0.6	-0.3
Neuroticism (Nagel 2018)	1.0	2.3	7.0	1.3	-1.1	2.6	0.7	1.0
Schizophrenia (2018)	1.4	2.9	12.0	-0.1	-1.2	3.5	-0.5	1.0
Schizophrenia vs Biploar Disorder	1.1	1.4	3.8	-1.9	1.0	1.5	0.0	-0.2
Worry (Nagel 2018)	3.3	7.0	12.1	2.8	-2.4	3.5	0.6	3.0
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	-0.0	1.1	0.7	-0.1	0.9
Alzheimer’s Disease (in father)	1.0	1.0	3.2	-1.0	1.0	-0.1	1.8	0.1
Alzheimer’s Disease (including proxy)	0.6	0.9	2.1	-0.7	1.4	0.0	1.4	0.2
Crohns Disease (2017)	0.5	1.0	2.0	1.3	0.1	1.4	0.4	1.1
Irritable Bowel Disease (IBD)	1.5	3.7	7.8	2.8	-1.1	2.2	-0.4	2.1
Ulcerative Colitis (UC)	1.5	2.8	5.5	2.4	-1.5	1.8	-0.4	1.8
Major Depression (MDD)	1.2	1.5	3.8	-0.6	-0.4	1.7	-2.0	0.3
Reaction Time	0.2	0.4	1.2	-1.1	0.6	-0.0	0.5	-0.5
Verbal and Numeric Reasoning (VNR)	0.9	2.2	8.3	-0.8	2.9	0.2	1.5	-0.3
Breast Cancer	0.4	0.9	2.5	-0.1	1.1	0.5	0.5	1.6
Ovarian Cancer	0.3	0.4	0.9	-0.2	0.3	0.9	-0.2	0.9
Prostate Cancer	2.3	3.3	5.4	2.3	-1.0	1.8	-1.7	1.9
Age at First Birth	0.4	0.6	1.5	1.2	-0.2	-1.1	0.1	-0.6
Bipolar Disorder (2011)	1.9	1.8	4.1	2.0	-0.8	1.5	-1.4	-0.2
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	-0.1	0.1	-0.0	-0.0	0.6
Coronary Artery Disease (CAD)	1.7	2.1	10.2	3.2	-0.2	0.2	-0.3	0.2
Crohns Disease (2012)	1.4	2.2	5.0	1.1	0.4	2.2	-0.0	2.1
Mean Putamen Volume	0.3	0.4	1.3	-1.2	-0.5	-0.2	0.4	0.0
Fasting Glucose	0.9	1.1	3.1	1.8	-0.7	0.5	0.7	1.1
HbA1C	0.7	0.8	1.6	-0.6	-0.3	0.8	1.3	1.1
HDL Cholesterol	0.4	0.7	3.1	-1.7	0.4	0.5	-0.3	0.1
LDL Cholesterol	0.8	1.3	2.2	-1.5	-1.2	-1.0	1.3	0.6
Lupus	0.8	1.2	2.7	-0.6	0.8	-0.8	1.6	-1.3
Neuroticism (2016)	0.2	0.3	0.7	0.5	-0.8	0.8	0.3	-0.3
Primary Biliary Cirrhosis	0.7	1.1	4.0	0.7	-2.0	0.2	-0.5	0.8
Rheumatoid Arthritis	1.3	1.8	5.1	-2.2	1.6	0.6	-0.7	-0.5
Schizophrenia (2014)	1.6	3.6	15.4	-0.0	-1.3	3.9	0.4	0.8
Triglycerides	0.5	0.8	1.5	1.1	0.6	0.6	0.5	1.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.2	0.3	1.1	-0.2	-1.5	-1.3
Ulcerative Colitis	2.3	3.4	7.8	2.8	-1.4	1.8	-0.5	1.9
Blood Eosinophil Count	0.3	2.5	4.5	-1.7	-2.1	-1.3	0.5	-1.8
Blood Platelet Count	0.3	3.9	16.9	-4.1	1.4	0.4	0.2	-0.7
Blood Red Count	0.1	0.8	2.1	-1.0	-0.8	-0.7	-1.4	-0.1
Blood White Count	0.3	2.4	9.0	-3.0	-0.5	-0.8	1.4	-0.5
Heel T-Score	1.0	8.3	29.5	5.4	-2.0	0.9	1.0	2.5
BMI	0.8	4.4	7.8	-1.7	1.9	-1.8	-2.1	-2.8
Height	0.1	1.2	3.2	1.4	-0.1	0.9	-0.1	1.8
Waist Hip Ratio (WHR)	0.2	1.0	3.2	0.5	-0.1	0.7	1.1	1.8
Systolic Blood Pressure	0.1	0.3	1.0	-1.0	-0.4	-0.6	-0.2	-0.1
Smoking Status	1.1	2.5	5.2	-1.4	-1.5	-1.4	2.3	1.1
Allergy or Eczema	0.3	0.8	1.9	0.7	1.3	0.4	-0.2	-1.4
Cardiovascular Disease	0.7	2.4	4.2	-2.0	1.3	-0.6	1.6	-1.7
Hypothyroidism (self reported)	2.0	4.6	9.1	1.9	-0.7	3.0	1.1	3.0
Respiratory disease	0.3	0.7	1.4	0.2	1.0	0.1	1.0	-1.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.4	-0.9	1.1	-1.8	-0.1	-0.4
Lung FEV1/FVC ratio	0.5	2.7	5.0	-1.6	0.3	-2.2	-1.6	-1.9
Lung FVC	0.5	2.3	4.6	-2.2	-0.1	-0.4	1.9	1.8
Neuroticism	1.3	3.2	8.8	1.5	-1.2	3.0	1.2	1.4
Chronotype (morning person)	0.6	1.4	3.5	-1.9	-1.1	-1.0	0.6	0.9
Hair Pigment	0.0	1.4	6.2	0.4	-0.0	0.3	-2.5	0.8
Tanning	0.1	0.7	2.5	-0.3	-0.1	-0.9	1.6	0.2
Hand grip strength (left)	0.5	1.3	3.8	-1.5	0.6	-1.9	-0.2	-0.3
Number of treatments/medications taken	1.5	2.7	4.2	1.8	-1.7	2.0	1.3	1.2
Average weekly spirits intake	0.4	0.5	2.1	0.0	0.4	0.6	1.4	0.1
Sensitivity / hurt feelings	1.2	2.0	6.1	1.6	-2.5	-0.0	-0.0	1.3
Frequency of depressed mood in last 2 weeks	1.0	1.3	3.5	-0.0	0.2	1.9	1.8	-0.0
Hearing difficulty/problems: Yes	0.6	0.9	1.8	-1.3	0.8	-0.6	1.2	-0.7
Relative age of first facial hair	2.9	6.0	16.5	-4.1	2.6	-0.4	-0.2	-2.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.5	1.6	-0.5	1.4	0.2	-0.7
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.0	0.6	-0.7	1.7	1.3	1.7
Ever had hysterectomy (womb removed)	0.7	0.8	2.3	-0.4	-1.5	1.3	-0.2	-0.1
Systolic blood pressure, automated reading	0.2	0.5	1.1	0.8	-1.1	0.1	-0.9	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.1	-0.3	-0.3	-0.6	-0.1
Angina	0.4	0.5	1.0	0.2	0.8	-0.8	1.0	-0.5
Medication for hormone replacement therapy	0.3	0.4	0.9	0.0	0.8	0.6	0.9	0.1
Vitamin and mineral supplements	1.9	2.6	11.8	0.3	0.9	-3.4	0.6	0.4
Supplements: Zinc	1.3	1.4	3.2	1.1	-1.1	1.8	0.4	1.2
Medication: Co-codamol	0.6	0.7	2.0	1.0	-1.4	0.5	0.1	-0.2
Medication: Metformin	0.9	1.2	1.9	1.3	-1.0	-1.4	0.6	1.0
Diabetes (father)	0.6	0.7	1.5	-0.9	-0.3	-0.0	-1.1	1.2
Diabetes (mother)	1.5	2.0	4.7	2.2	-1.4	-0.9	-1.5	0.3
Severe depression (siblings)	0.8	0.9	1.8	-0.6	-0.6	1.3	1.3	-0.4
Pack years adult smoking proportion	0.7	1.1	3.5	0.4	-1.9	1.3	-0.2	0.6
Impedance of leg (right)	1.1	5.4	11.8	3.4	0.4	2.5	0.7	2.8
Leg fat-free mass (left)	0.7	3.8	8.1	-2.4	0.3	-2.3	0.2	-2.8
Trunk fat percentage	0.2	0.6	1.2	1.1	0.4	0.8	-1.1	-0.2
Hand grip strength (right)	1.3	3.7	8.1	-2.9	1.8	-2.3	0.4	-1.3
Townsend deprivation index at recruitment	0.2	0.3	0.9	-1.0	-0.1	0.2	0.8	0.1
Current tobacco smoking	2.3	3.7	10.6	-3.3	-0.8	-1.7	1.7	-1.2
Average weekly fortified wine intake	0.3	0.4	1.1	0.0	-0.1	0.8	-1.1	-0.3
Maternal smoking around birth	0.5	0.8	2.1	-1.5	0.2	-1.0	0.5	-0.7
Fed-up feelings	0.2	0.3	0.5	0.4	0.2	0.7	0.7	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.6	-0.2	-0.0	1.6	0.3	0.2
Relative age voice broke	0.8	1.2	2.9	-1.7	0.6	-1.1	-0.8	-1.0
Taking other prescription medications	1.3	2.0	4.2	1.8	-1.2	2.0	0.8	0.6
Age when periods started (menarche)	0.5	1.3	3.3	1.8	-0.8	0.3	-1.3	0.7
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.6	-0.6	-1.9	-0.1	1.8	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	8.3	2.9	-1.4	0.0	-0.0	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.3	-0.4	0.1	-0.7	1.1	-0.5
Qualifications: CSEs or equivalent	2.1	2.8	4.6	-2.1	-0.7	-2.0	1.4	-1.8
Serious illness, injury or assault to yourself	0.4	0.5	0.9	1.0	0.3	-0.8	-0.5	0.6
High blood pressure	0.3	0.8	1.7	-1.3	0.1	0.6	0.6	-1.1
Hayfever, allergic rhinitis or eczema	1.1	2.3	5.5	-1.5	1.9	0.2	-0.3	-2.3
Multivitamins +/- minerals	2.1	2.7	10.7	-0.3	-0.2	3.3	-0.7	-1.4
Stomach or abdominal pain in last month	1.4	1.8	6.3	-0.7	0.9	2.5	0.1	-1.1
Supplements: Glucosamine	1.7	2.2	4.6	2.2	-1.5	0.4	-1.8	0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.6	-0.7	-0.3	-1.1	-1.3	-0.3
Medication: Atenolol	0.6	0.7	2.1	0.1	-0.3	0.8	-1.4	-0.9
Medication: Levothyroxine sodium	2.6	4.4	10.6	1.0	-1.5	2.8	0.5	3.2
Sitting height	0.2	1.3	3.6	1.9	-1.6	0.0	0.3	0.3
Chronic bronchitis/emphysema (father)	0.4	0.5	1.1	0.5	-0.5	-0.8	1.1	-0.3
High blood pressure (mother)	0.9	1.2	5.1	-0.7	0.5	-0.1	0.3	-2.3
Body mass index (BMI)	0.4	1.8	3.8	-1.3	0.6	-1.3	-1.4	-1.9
Impedance of leg (left)	1.0	4.9	10.0	3.2	0.4	2.7	0.4	2.6
Leg predicted mass (left)	0.8	4.0	8.7	-2.4	0.4	-2.4	0.1	-3.0
Trunk fat mass	0.1	0.4	1.1	0.3	0.5	0.3	-1.0	-0.7
Waist circumference	0.2	0.6	1.1	-0.7	0.5	-0.7	-1.0	-0.9
Number of incorrect matches in round	1.7	2.9	6.1	0.6	-2.5	-0.9	2.5	1.1
Past tobacco smoking	0.8	1.5	5.6	-0.4	1.1	0.1	-0.7	-2.4
Alcohol usually taken with meals	0.8	1.3	2.9	-0.7	0.9	1.7	-1.5	0.4
Nervous feelings	1.4	2.7	4.4	2.0	-0.9	2.1	0.0	2.0
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.7	10.8	1.7	-0.9	3.3	0.5	1.9
Hearing difficulty/problems with background noise	0.4	0.7	2.2	-1.5	-0.2	0.4	0.8	-0.6
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	0.9	0.3	-0.8	-0.2	-1.0
Had menopause	4.6	5.8	13.0	1.9	-2.0	3.6	-1.0	2.6
Had other major operations	0.5	0.6	1.8	-0.7	-0.6	-0.1	-1.3	-0.3
Forced vital capacity (FVC)	0.4	1.6	4.5	-1.8	0.1	-2.1	-0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	5.9	2.4	-0.6	0.2	-0.3	0.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.0	-0.6	0.2	1.4	0.9	-0.4
Qualifications: None of the above	0.8	1.6	3.7	1.3	-1.6	-0.1	0.4	1.9
Financial difficulties in last 2 years	0.3	0.3	1.3	0.6	0.1	-0.3	1.1	0.1
Mouth/teeth dental problems	0.7	1.1	3.4	-0.1	1.1	-0.3	-1.8	-0.8
Heart attack	1.2	1.5	5.3	0.2	0.7	2.3	1.4	0.2
Allergy	0.7	1.6	4.1	1.1	-1.5	-0.7	-0.1	2.0
Pain all over the body in last month	0.4	0.5	1.3	-0.4	0.5	0.7	0.2	1.1
Diabetes (self-reported)	0.1	0.2	0.5	-0.3	-0.1	-0.4	-0.3	0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.2	-0.3	0.3	-0.0	-0.7	-1.8
Medication: Ramipril	0.1	0.1	0.3	0.1	-0.0	-0.3	0.6	0.3
Medication: Simvastatin	0.9	1.4	2.8	-0.3	1.2	-1.7	1.1	-1.2
Fluid intelligence score	0.6	1.3	5.5	-0.3	2.3	0.2	0.8	-0.1
Illnesses of siblings	0.6	0.8	2.8	-0.1	0.2	0.9	-1.7	0.4
Neuroticism score	2.0	4.3	11.0	1.1	-1.2	3.3	2.4	1.4
Weight	0.3	1.3	3.0	-1.0	0.6	-1.2	-0.9	-1.7
Impedance of arm (right)	0.9	4.1	7.3	2.6	-0.2	2.7	0.1	2.5
Arm fat percentage (right)	0.1	0.5	1.6	-0.2	0.5	0.2	-1.3	-0.9
Trunk fat-free mass	0.5	3.0	6.1	-2.1	-0.1	-2.5	0.1	-2.1
Hip circumference	0.5	2.4	4.9	-1.3	1.6	-1.0	-1.3	-2.2
Time employed in main current job	0.2	0.2	0.4	0.3	0.5	-0.2	0.6	0.4
Alcohol intake versus 10 years previously	0.4	0.5	1.4	-0.3	0.2	0.0	1.1	-1.2
Father’s age at death	0.3	0.4	0.7	-0.8	0.3	0.5	-0.9	0.2
Worrier / anxious feelings	4.2	8.0	17.6	3.0	-3.0	4.2	0.1	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.9	1.5	-0.4	2.0	0.1	1.8
Falls in the last year	1.0	1.4	1.9	1.1	-1.1	1.3	1.4	-0.9
Hair/balding pattern: Pattern 3	0.9	1.3	3.5	0.6	-0.4	1.4	0.8	1.9
Number of live births	0.3	0.5	0.9	-1.0	-0.2	-0.6	0.4	0.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	8.3	-2.3	0.2	-2.9	-0.4	-0.2
Pulse rate	0.5	0.9	3.5	0.4	-0.4	0.8	0.1	1.9
Happiness	0.9	1.0	2.6	0.8	1.0	-0.4	1.6	0.9
Noisy workplace	0.3	0.3	1.2	-0.3	1.1	-0.1	-0.1	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	-0.7	1.1	0.3	-0.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	-1.2	-0.2	0.2	1.1	-0.8
Mouth/teeth dental problems: Dentures	1.2	2.0	5.8	-1.6	1.2	-0.4	2.4	-0.5
Asthma	0.6	1.1	2.2	0.4	1.2	1.1	-0.6	-1.5
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.6	6.0	-2.5	2.0	-0.8	0.9	-1.4
Medication: Cholesterol lowering	1.5	2.3	7.7	0.3	1.2	1.4	2.8	-0.2
Depression (self-reported)	0.7	0.9	1.3	-0.6	1.2	0.9	-0.8	1.1
Medication: Lansoprazole	1.5	1.7	3.5	1.6	0.6	-1.5	0.3	-1.9
Prospective memory result	0.7	0.9	1.9	-0.6	-1.2	-1.4	-0.7	0.2
Lung cancer (father)	1.2	1.5	2.8	-1.7	1.2	-1.1	0.3	-1.2
Illnesses of mother	0.5	0.6	2.3	-1.5	-0.2	0.2	0.5	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.7	-1.9	0.5	-1.9	-0.0	-0.1
Pulse wave Arterial Stiffness index	0.9	1.0	3.2	0.4	-1.1	-0.4	-0.6	1.8
Impedance of arm (left)	1.0	4.7	9.0	2.6	-0.2	3.0	0.5	2.8
Arm fat mass (right)	0.3	1.0	2.6	-0.7	0.3	-0.6	-1.3	-1.6
Trunk predicted mass	0.5	2.9	6.2	-2.1	-0.2	-2.5	0.1	-2.0
Standing height	0.0	0.3	0.5	0.7	-0.4	0.2	0.7	0.6
Length of working week for main job	1.0	1.1	3.1	-1.8	0.8	-0.8	-0.4	-1.0
Exposure to tobacco smoke at home	1.9	2.2	5.0	2.2	-1.9	-0.3	-0.9	1.1
Breastfed as a baby	1.2	1.4	2.1	-0.3	-1.4	1.5	1.0	1.4
Tense / ‘highly strung’	1.4	2.3	3.9	0.9	-1.0	2.0	1.5	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.8	7.9	0.7	-2.8	0.7	1.9	2.5
Hair/balding pattern: Pattern 4	0.3	0.7	1.5	0.2	0.8	-1.2	-0.9	-0.7
Birth weight of first child	0.8	1.4	5.1	0.5	-0.1	2.3	-0.5	1.2
Peak expiratory flow (PEF)	1.3	3.0	7.4	-2.7	0.7	-2.7	0.1	-0.2
Pulse wave reflection index	0.1	0.2	0.3	-0.3	-0.3	0.5	-0.4	0.6
Ever highly irritable/argumentative for 2 days	0.9	1.0	2.3	-1.4	0.3	1.5	0.5	-0.6
Loud music exposure frequency	0.5	0.5	1.7	-0.2	-0.8	0.3	1.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.8	0.8	0.1	-0.2	-0.2
Mouth/teeth dental problems: Bleeding gums	3.6	4.6	9.8	1.8	-2.6	1.7	-0.5	3.1
Blood clot in the leg (DVT)	0.8	1.1	2.8	0.8	-1.2	0.4	0.5	1.7
Medication: Paracetamol	0.1	0.1	0.3	0.2	-0.2	-0.5	0.4	-0.5
Headache pain in last month	0.9	1.5	3.3	1.8	-1.1	1.4	0.8	0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	7.3	-0.1	-0.3	-0.8	-2.7	0.7
Glaucoma (self-reported)	0.2	0.2	0.5	0.5	0.7	0.5	0.0	0.3
Gout (self-reported)	0.6	0.9	2.7	0.6	0.1	-0.4	-1.6	-1.1
Hypothyroidism/myxoedema (self-reported)	3.2	6.3	14.0	1.6	-1.6	3.3	1.3	3.7
Medication: Amlodipine	0.3	0.5	1.2	-0.2	1.0	-0.2	1.1	0.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.1	0.5	0.2	0.3	-0.3	-1.5
Birth weight	0.6	1.3	2.5	-1.4	-0.0	0.6	-1.2	-1.6
Chronic bronchitis/emphysema (mother)	1.1	1.2	4.2	-0.9	1.1	0.0	-0.1	-2.0
High blood pressure (siblings)	0.8	1.2	3.0	0.2	-1.7	-1.2	1.1	0.8
Forced vital capacity (FVC), Best measure	0.4	1.6	3.6	-1.9	1.0	-1.6	0.8	-0.4
Body fat percentage	0.1	0.5	1.3	0.7	0.6	0.8	-1.1	-0.1
Leg fat percentage (right)	0.1	0.5	1.3	0.3	1.1	0.7	-0.7	-0.1
Arm fat-free mass (right)	0.6	3.3	5.9	-2.2	0.6	-2.3	0.3	-2.4
Exposure to tobacco smoke outside home	0.9	1.2	3.8	-2.0	0.5	-0.1	0.8	-1.0
Comparative body size at age 10	1.3	3.6	11.0	-2.0	-1.1	-3.3	-1.0	-0.8
Number of full brothers	0.9	1.2	3.2	-1.8	1.0	-0.7	1.1	-0.4
Worry too long after embarrassment	1.1	1.8	5.6	-1.5	0.3	2.4	0.4	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	5.8	0.6	-0.6	2.4	1.0	0.8
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	-0.6	-0.4	0.6	0.3	-1.3
Number of children fathered	1.0	1.2	3.8	-0.0	0.5	1.3	-1.9	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	2.7	0.1	0.4	0.9	-1.6	-0.3
Age at first live birth	0.3	0.5	1.3	0.6	0.7	-1.1	0.3	0.6
Pulse wave peak to peak time	0.8	0.9	2.4	-0.4	1.2	0.4	0.7	-1.6
Health satisfaction	1.0	1.4	2.7	-0.5	1.6	-0.9	1.1	-1.4
Shortness of breath walking on level ground	0.6	0.7	2.4	-1.6	0.7	0.1	0.1	-0.9
Qualifications: College or University degree	0.8	2.6	8.0	-1.3	2.8	1.3	1.2	-0.3
Eye problems/disorders: None of the above	0.3	0.4	1.0	-0.8	0.0	1.0	-0.0	-0.6
Mouth/teeth dental problems: Loose teeth	1.9	2.2	3.7	1.9	-1.8	-0.4	1.4	1.5
Emphysema/chronic bronchitis	1.5	1.7	3.7	-1.9	1.1	-0.9	1.4	-0.9
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	0.1	0.8	0.1	-0.7	0.8
Neck or shoulder pain in last month	0.5	0.8	2.0	0.4	-0.7	-0.3	-1.0	-1.4
Medication: Blood pressure	0.5	0.8	2.5	-0.4	0.3	0.9	1.6	-0.6
Angina (self-reported)	0.3	0.4	1.0	0.3	0.6	-1.0	0.6	-0.5
Migraine (self-reported)	0.3	0.4	1.4	-0.1	-1.2	0.5	-0.3	0.3
Medication: Ibuprofen	1.9	2.3	7.1	-2.7	0.9	-0.2	1.6	-0.9
Medication: Allopurinol	0.3	0.3	1.1	0.5	-0.1	-0.4	-1.1	-0.4
Medication: Omeprazole	1.4	1.6	3.2	1.8	-0.9	1.7	0.6	1.0
Medication: Seretide 50 evohaler	0.8	0.9	2.3	-0.2	1.5	-0.3	-0.9	-1.1
Mean time to correctly identify matches	0.5	1.0	2.8	0.1	-0.7	0.9	0.8	1.7
Heart disease (mother)	1.1	1.4	5.5	2.3	-0.7	0.6	0.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	1.1	-0.3	-0.2	-0.7	-1.0
Whole body fat mass	0.1	0.6	1.3	-0.3	0.6	-0.1	-1.2	-1.0
Leg fat mass (right)	0.1	0.4	0.7	-0.4	0.8	-0.3	-0.6	-0.8
Arm predicted mass (right)	0.6	3.2	6.1	-2.1	0.5	-2.3	-0.1	-2.5
Pulse rate, automated reading	0.3	1.0	2.8	-0.4	0.8	0.5	-0.9	1.7
Alcohol intake frequency.	0.2	0.4	0.9	0.2	-1.0	0.9	0.1	-0.6
Comparative height size at age 10	0.1	0.7	1.9	1.4	-0.5	-0.7	0.9	0.3
Number of full sisters	1.9	2.3	5.4	1.3	0.1	2.0	-0.8	2.3
Suffer from ‘nerves’	1.7	2.6	7.4	0.6	-1.4	2.7	1.2	1.4
Overall health rating	0.7	1.4	3.6	-0.5	0.3	0.8	1.6	-1.9
Chest pain or discomfort	0.4	0.6	1.0	-0.2	1.0	0.2	-0.9	-1.0
Had major operations	0.1	0.1	0.6	-0.0	-0.1	0.2	-0.3	-0.8
Age at last live birth	0.3	0.4	1.0	0.4	0.4	0.1	1.0	0.9
Family relationship satisfaction	1.2	1.4	6.5	-0.3	-0.6	-0.3	2.5	0.4
Leg pain on walking	0.3	0.4	1.4	0.7	-0.3	0.2	1.2	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.3	0.2	0.3	-0.1	-1.1	0.2
Commuting to job workplace: Car/motor vehicle	2.1	2.4	7.1	0.7	1.0	-0.5	-2.7	-1.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.0	-1.0	-0.0	-0.1	-0.5	-0.9
Medication: Aspirin	0.3	0.4	1.0	0.4	-1.0	0.7	0.3	0.4
Supplements: Vitamin C	0.4	0.5	1.3	-0.0	-0.6	1.1	-0.9	0.2
Knee pain experienced in last month	0.4	0.6	2.7	0.0	-0.3	-1.6	-0.0	-0.3
Hypertension (Self-reported)	0.2	0.5	1.4	-1.2	-0.3	0.5	0.6	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.7	4.4	14.0	3.7	-1.0	0.9	2.4	0.5
Illnesses of father: Heart disease	0.5	0.7	1.5	0.4	1.0	-1.0	-1.2	0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.6	-0.7	-0.2	0.1	0.2
Smoking status: Previous	1.1	1.7	4.8	1.2	-1.2	-0.3	0.7	2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.0	-0.3	0.1	-1.7	-0.3	-1.7
Whole body fat-free mass	0.7	3.9	7.1	-2.4	0.3	-2.5	0.1	-2.7
Leg fat-free mass (right)	0.9	4.6	9.9	-2.7	0.3	-2.4	0.0	-3.1
Arm fat percentage (left)	0.1	0.4	1.3	-0.3	0.4	0.5	-1.1	-0.6
Average weekly red wine intake	0.8	1.2	3.2	-1.8	1.2	1.1	0.3	0.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	-0.9	0.7	0.3	-0.5	0.2
Mood swings	1.1	2.0	3.8	1.2	-1.2	1.6	2.0	0.7
Loneliness, isolation	0.8	1.1	4.0	0.7	-0.1	2.0	1.1	-0.0
Long-standing illness, disability or infirmity	0.5	0.8	1.9	1.0	0.7	0.7	-0.5	-1.4
Ever had bowel cancer screening	2.0	2.4	7.8	1.4	-0.8	2.8	-0.7	0.9
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.5	0.3	-0.3	0.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.6	-0.9	0.6	-1.0	1.2	0.3
Friendships satisfaction	0.8	1.0	2.9	-0.1	0.2	1.4	1.7	0.5
Qualifications: nursing, teaching	0.4	0.7	1.4	0.5	0.6	0.8	-1.2	0.8
Commuting to job workplace: Walk	1.7	1.9	3.3	-0.7	-0.7	1.7	1.4	1.8
Eye problems/disorders: Cataract	0.8	1.0	3.0	0.6	-1.0	-1.7	0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	-0.4	0.4	-0.1	1.3	-0.8
Medication for cholesterol	0.4	0.6	1.1	1.0	-1.1	1.0	0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	3.1	-1.1	1.8	0.3	-1.4	-1.0
Back pain experienced in last month	0.7	1.0	1.7	1.3	-1.2	0.5	1.1	-0.6
Mineral and other dietary supplements	0.4	0.5	1.2	-0.8	0.6	-1.1	-0.5	-0.4
Breast cancer (self-reported)	0.2	0.3	0.5	-0.7	-0.3	0.6	-0.4	-0.4
Asthma (self-reported)	0.6	1.2	2.0	0.4	1.2	1.4	-0.7	-1.4
Osteoporosis (self-reported)	2.5	3.1	5.3	0.8	-2.2	2.3	-0.0	2.2
Osteoarthritis (self-reported)	1.0	1.3	4.2	2.0	-0.2	0.9	0.9	-0.7
Medication: Aspirin	0.2	0.2	0.9	0.1	-0.9	0.3	0.2	0.4
Medication: Gliclazide	0.6	0.7	1.6	-0.9	-0.4	-1.3	-0.3	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.4	0.9	0.8	-0.3	0.5	0.6	-0.9
Smoking status: Current	1.8	2.9	10.7	-3.3	-0.2	-1.2	1.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	7.7	-1.7	0.2	-2.8	0.4	-1.0
Whole body water mass	0.7	4.0	7.1	-2.5	0.2	-2.6	0.1	-2.7
Leg predicted mass (right)	0.8	4.5	9.9	-2.6	0.3	-2.4	-0.0	-3.1
Arm fat mass (left)	0.2	0.8	1.8	-0.8	0.3	-0.5	-1.1	-1.4
Number of self-reported non-cancer illnesses	0.4	0.7	1.4	1.2	-1.1	0.4	0.5	-0.7
Average weekly champagne plus white wine intake	0.8	1.1	2.9	1.4	0.1	1.7	-0.7	0.4
Miserableness	1.2	2.0	6.4	0.1	0.4	2.5	1.9	-0.1
Guilty feelings	2.1	3.2	6.7	-1.0	-1.9	2.6	2.1	0.3
Wears glasses or contact lenses	1.5	1.7	3.0	1.7	-0.6	0.9	1.2	1.7
Ever taken oral contraceptive pill	2.1	2.3	6.0	-1.4	1.5	-2.5	0.7	-1.0
Hearing aid user	0.5	0.6	2.2	-0.5	-0.3	0.5	1.5	-0.1
Mother’s age at death	0.1	0.2	0.3	0.5	0.5	0.3	-0.4	0.3
Financial situation satisfaction	1.3	1.6	6.0	0.9	-0.0	0.6	2.5	0.8
Tinnitus: Yes, now most or all of the time	2.2	2.5	10.8	-1.1	-0.6	-0.3	3.3	-0.4
Commuting to job workplace: Public transport	1.8	2.2	5.9	-1.6	1.3	0.1	2.4	0.9
Eye problems/disorders: Glaucoma	0.2	0.3	0.9	0.5	-0.2	0.4	1.0	0.2
Medication: Blood pressure	0.3	0.6	1.2	-1.1	0.4	-0.3	-0.9	-0.9
Pain type(s) experienced in last month: Hip pain	2.3	2.9	10.0	1.5	1.3	3.2	-0.6	-0.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.1	1.4	-0.4	1.4	-0.1	0.4
High cholesterol (Self-reported)	0.5	0.9	3.2	0.5	0.6	-0.8	1.8	-0.5
Medication: Bendroflumethiazide	0.8	1.3	2.1	-1.4	0.6	0.7	-1.3	-1.3
Medication: Paracetamol	0.2	0.4	1.0	-0.3	0.4	-1.0	0.5	-0.6
Medication: Lisinopril	1.7	2.3	4.0	-2.0	1.3	-1.3	0.4	-1.9
Medication: Atorvastatin	3.2	4.0	7.9	1.7	-0.7	2.5	2.8	1.5
Illnesses of father: High blood pressure	0.6	0.8	2.2	-1.1	1.5	0.4	0.4	0.4
Alcohol drinker status: Never	0.6	0.7	1.3	-1.1	0.5	-0.8	0.5	-1.0
Ever smoked	1.2	2.2	5.0	-0.1	-1.7	-0.1	1.7	2.2
Basal metabolic rate	0.6	3.5	6.7	-2.2	0.3	-2.4	-0.1	-2.6
Leg fat percentage (left)	0.1	0.5	1.3	0.0	1.1	0.6	-1.0	-0.3
Arm fat-free mass (left)	0.6	2.8	5.6	-1.8	0.2	-2.3	-0.2	-2.4
Number of operations (self-reported)	1.2	1.8	3.6	-1.6	0.6	0.1	-1.6	-1.9
Average weekly beer plus cider intake	1.8	2.6	6.4	1.7	-1.0	-2.5	0.7	1.4
Irritability	2.0	3.4	7.3	2.7	-1.8	1.2	2.0	1.2
Risk taking	0.7	1.1	2.2	-1.4	0.5	-1.5	-0.1	-0.9
Ever had prostate specific antigen (PSA) test	1.9	2.2	9.3	0.1	-0.8	3.0	1.1	-0.3
Fractured/broken bones in last 5 years	1.3	1.7	4.2	2.1	-1.6	1.0	-0.4	-0.9
Age started oral contraceptive pill	1.1	1.3	2.3	1.5	0.4	1.4	-0.6	1.3
Diastolic blood pressure, automated reading	0.4	1.2	4.5	-0.6	-0.5	-0.9	2.1	-0.1
Ever depressed for a whole week	0.7	0.9	3.7	-0.5	-0.7	1.9	0.3	-0.2
Unable to work because of sickness or disability	1.8	2.3	4.6	2.1	-1.8	0.8	1.0	1.4
Commuting to job workplace: Cycle	1.6	1.9	4.1	-1.0	-0.6	-1.7	2.0	-1.2
Myopia	0.3	0.4	0.9	-0.9	0.8	0.5	0.0	0.5
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.3	1.4	-0.7	-0.8	-0.5	1.5
Cholesterol lowering medication	0.2	0.3	1.0	-0.3	0.3	-1.0	0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	0.8	0.1	1.0	0.5	-0.1
Pain experienced in last month	0.3	0.6	1.5	0.1	-0.3	-1.1	-0.5	1.2
Supplements: Calcium	1.6	1.8	3.5	1.0	-1.4	1.9	-0.3	1.6
Basal cell carcinoma (self-reported)	0.7	0.9	2.1	-0.1	-0.2	0.4	-1.4	-1.4
Heart attack/myocardial infarction (self-reported)	1.2	1.5	5.4	0.4	0.4	2.3	1.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.4	0.8	-1.0	0.3	0.8	1.6
Heart disease (siblings)	1.4	1.7	3.5	-1.0	1.9	-0.6	-1.0	-1.7
Alcohol drinker status: Previous	1.4	1.6	3.6	1.5	-0.7	-1.9	1.2	-0.2
Pack years of smoking	0.7	1.1	2.7	0.4	-1.6	1.4	-0.0	0.7
Impedance of whole body	1.2	5.9	11.4	3.4	0.2	3.1	0.3	2.9
Leg fat mass (left)	0.1	0.6	1.3	-0.6	0.8	-0.2	-0.7	-1.1
Arm predicted mass (left)	0.6	3.0	6.2	-1.7	0.2	-2.5	-0.3	-2.5