Hub : Genes

C1orf95

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0860 0.0350 2.1e-04 0.010 0.027 0.049 0.034 0.036 2.0e-02 3.0e-04 1.3e-06 5.3e-05 2.7e-05
2 GTEx Nerve Tibial 0.4494 0.0572 1.8e-15 0.330 NA 0.329 NA 0.325 5.4e-24 NA 6.4e-24 NA 1.4e-23
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.1170 0.0580 3.6e-03 0.106 0.034 0.068 NA 0.086 1.2e-06 5.0e-03 9.9e-05 NA 1.2e-05
4 TCGA Brain Lower Grade Glioma 0.1113 0.0368 1.0e-05 0.059 0.051 0.059 NA 0.059 2.6e-07 1.7e-06 2.6e-07 NA 2.6e-07
5 TCGA Prostate Adenocarcinoma 0.0595 0.0241 4.6e-04 0.015 0.021 0.002 NA 0.010 1.0e-02 2.8e-03 1.8e-01 NA 2.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.5 2.4 4.0 2.0 -1.7 1.9 -1.3 0.1
Bipolar Disorder or Schizophrenia 1.9 4.5 15.0 1.3 -1.9 3.9 -1.2 0.9
Depressed Affect (Nagel 2018) 0.3 0.6 1.2 0.5 0.9 0.8 1.1 -0.5
Depression (Nagel 2018) 0.3 0.5 1.7 0.3 0.6 1.3 -0.4 0.4
Intelligence (Savage-Jansen 2018) 0.5 1.4 6.6 -0.4 2.6 0.1 0.6 -0.3
Neuroticism (Nagel 2018) 1.0 2.3 7.0 1.3 -1.1 2.6 0.7 1.0
Schizophrenia (2018) 1.4 2.9 12.0 -0.1 -1.2 3.5 -0.5 1.0
Schizophrenia vs Biploar Disorder 1.1 1.4 3.8 -1.9 1.0 1.5 0.0 -0.2
Worry (Nagel 2018) 3.3 7.0 12.1 2.8 -2.4 3.5 0.6 3.0
Alzheimer’s Disease (in mother) 0.4 0.5 1.2 -0.0 1.1 0.7 -0.1 0.9
Alzheimer’s Disease (in father) 1.0 1.0 3.2 -1.0 1.0 -0.1 1.8 0.1
Alzheimer’s Disease (including proxy) 0.6 0.9 2.1 -0.7 1.4 0.0 1.4 0.2
Crohns Disease (2017) 0.5 1.0 2.0 1.3 0.1 1.4 0.4 1.1
Irritable Bowel Disease (IBD) 1.5 3.7 7.8 2.8 -1.1 2.2 -0.4 2.1
Ulcerative Colitis (UC) 1.5 2.8 5.5 2.4 -1.5 1.8 -0.4 1.8
Major Depression (MDD) 1.2 1.5 3.8 -0.6 -0.4 1.7 -2.0 0.3
Reaction Time 0.2 0.4 1.2 -1.1 0.6 -0.0 0.5 -0.5
Verbal and Numeric Reasoning (VNR) 0.9 2.2 8.3 -0.8 2.9 0.2 1.5 -0.3
Breast Cancer 0.4 0.9 2.5 -0.1 1.1 0.5 0.5 1.6
Ovarian Cancer 0.3 0.4 0.9 -0.2 0.3 0.9 -0.2 0.9
Prostate Cancer 2.3 3.3 5.4 2.3 -1.0 1.8 -1.7 1.9
Age at First Birth 0.4 0.6 1.5 1.2 -0.2 -1.1 0.1 -0.6
Bipolar Disorder (2011) 1.9 1.8 4.1 2.0 -0.8 1.5 -1.4 -0.2
Body Mass Index (BMI) (2010) 0.1 0.1 0.4 -0.1 0.1 -0.0 -0.0 0.6
Coronary Artery Disease (CAD) 1.7 2.1 10.2 3.2 -0.2 0.2 -0.3 0.2
Crohns Disease (2012) 1.4 2.2 5.0 1.1 0.4 2.2 -0.0 2.1
Mean Putamen Volume 0.3 0.4 1.3 -1.2 -0.5 -0.2 0.4 0.0
Fasting Glucose 0.9 1.1 3.1 1.8 -0.7 0.5 0.7 1.1
HbA1C 0.7 0.8 1.6 -0.6 -0.3 0.8 1.3 1.1
HDL Cholesterol 0.4 0.7 3.1 -1.7 0.4 0.5 -0.3 0.1
LDL Cholesterol 0.8 1.3 2.2 -1.5 -1.2 -1.0 1.3 0.6
Lupus 0.8 1.2 2.7 -0.6 0.8 -0.8 1.6 -1.3
Neuroticism (2016) 0.2 0.3 0.7 0.5 -0.8 0.8 0.3 -0.3
Primary Biliary Cirrhosis 0.7 1.1 4.0 0.7 -2.0 0.2 -0.5 0.8
Rheumatoid Arthritis 1.3 1.8 5.1 -2.2 1.6 0.6 -0.7 -0.5
Schizophrenia (2014) 1.6 3.6 15.4 -0.0 -1.3 3.9 0.4 0.8
Triglycerides 0.5 0.8 1.5 1.1 0.6 0.6 0.5 1.2
Type 2 Diabetes (T2D) (2012) 0.9 1.0 2.2 0.3 1.1 -0.2 -1.5 -1.3
Ulcerative Colitis 2.3 3.4 7.8 2.8 -1.4 1.8 -0.5 1.9
Blood Eosinophil Count 0.3 2.5 4.5 -1.7 -2.1 -1.3 0.5 -1.8
Blood Platelet Count 0.3 3.9 16.9 -4.1 1.4 0.4 0.2 -0.7
Blood Red Count 0.1 0.8 2.1 -1.0 -0.8 -0.7 -1.4 -0.1
Blood White Count 0.3 2.4 9.0 -3.0 -0.5 -0.8 1.4 -0.5
Heel T-Score 1.0 8.3 29.5 5.4 -2.0 0.9 1.0 2.5
BMI 0.8 4.4 7.8 -1.7 1.9 -1.8 -2.1 -2.8
Height 0.1 1.2 3.2 1.4 -0.1 0.9 -0.1 1.8
Waist Hip Ratio (WHR) 0.2 1.0 3.2 0.5 -0.1 0.7 1.1 1.8
Systolic Blood Pressure 0.1 0.3 1.0 -1.0 -0.4 -0.6 -0.2 -0.1
Smoking Status 1.1 2.5 5.2 -1.4 -1.5 -1.4 2.3 1.1
Allergy or Eczema 0.3 0.8 1.9 0.7 1.3 0.4 -0.2 -1.4
Cardiovascular Disease 0.7 2.4 4.2 -2.0 1.3 -0.6 1.6 -1.7
Hypothyroidism (self reported) 2.0 4.6 9.1 1.9 -0.7 3.0 1.1 3.0
Respiratory disease 0.3 0.7 1.4 0.2 1.0 0.1 1.0 -1.2
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.4 -0.9 1.1 -1.8 -0.1 -0.4
Lung FEV1/FVC ratio 0.5 2.7 5.0 -1.6 0.3 -2.2 -1.6 -1.9
Lung FVC 0.5 2.3 4.6 -2.2 -0.1 -0.4 1.9 1.8
Neuroticism 1.3 3.2 8.8 1.5 -1.2 3.0 1.2 1.4
Chronotype (morning person) 0.6 1.4 3.5 -1.9 -1.1 -1.0 0.6 0.9
Hair Pigment 0.0 1.4 6.2 0.4 -0.0 0.3 -2.5 0.8
Tanning 0.1 0.7 2.5 -0.3 -0.1 -0.9 1.6 0.2
Hand grip strength (left) 0.5 1.3 3.8 -1.5 0.6 -1.9 -0.2 -0.3
Number of treatments/medications taken 1.5 2.7 4.2 1.8 -1.7 2.0 1.3 1.2
Average weekly spirits intake 0.4 0.5 2.1 0.0 0.4 0.6 1.4 0.1
Sensitivity / hurt feelings 1.2 2.0 6.1 1.6 -2.5 -0.0 -0.0 1.3
Frequency of depressed mood in last 2 weeks 1.0 1.3 3.5 -0.0 0.2 1.9 1.8 -0.0
Hearing difficulty/problems: Yes 0.6 0.9 1.8 -1.3 0.8 -0.6 1.2 -0.7
Relative age of first facial hair 2.9 6.0 16.5 -4.1 2.6 -0.4 -0.2 -2.5
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.5 1.6 -0.5 1.4 0.2 -0.7
Ever used hormone-replacement therapy (HRT) 1.3 1.7 3.0 0.6 -0.7 1.7 1.3 1.7
Ever had hysterectomy (womb removed) 0.7 0.8 2.3 -0.4 -1.5 1.3 -0.2 -0.1
Systolic blood pressure, automated reading 0.2 0.5 1.1 0.8 -1.1 0.1 -0.9 0.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.1 -0.3 -0.3 -0.6 -0.1
Angina 0.4 0.5 1.0 0.2 0.8 -0.8 1.0 -0.5
Medication for hormone replacement therapy 0.3 0.4 0.9 0.0 0.8 0.6 0.9 0.1
Vitamin and mineral supplements 1.9 2.6 11.8 0.3 0.9 -3.4 0.6 0.4
Supplements: Zinc 1.3 1.4 3.2 1.1 -1.1 1.8 0.4 1.2
Medication: Co-codamol 0.6 0.7 2.0 1.0 -1.4 0.5 0.1 -0.2
Medication: Metformin 0.9 1.2 1.9 1.3 -1.0 -1.4 0.6 1.0
Diabetes (father) 0.6 0.7 1.5 -0.9 -0.3 -0.0 -1.1 1.2
Diabetes (mother) 1.5 2.0 4.7 2.2 -1.4 -0.9 -1.5 0.3
Severe depression (siblings) 0.8 0.9 1.8 -0.6 -0.6 1.3 1.3 -0.4
Pack years adult smoking proportion 0.7 1.1 3.5 0.4 -1.9 1.3 -0.2 0.6
Impedance of leg (right) 1.1 5.4 11.8 3.4 0.4 2.5 0.7 2.8
Leg fat-free mass (left) 0.7 3.8 8.1 -2.4 0.3 -2.3 0.2 -2.8
Trunk fat percentage 0.2 0.6 1.2 1.1 0.4 0.8 -1.1 -0.2
Hand grip strength (right) 1.3 3.7 8.1 -2.9 1.8 -2.3 0.4 -1.3
Townsend deprivation index at recruitment 0.2 0.3 0.9 -1.0 -0.1 0.2 0.8 0.1
Current tobacco smoking 2.3 3.7 10.6 -3.3 -0.8 -1.7 1.7 -1.2
Average weekly fortified wine intake 0.3 0.4 1.1 0.0 -0.1 0.8 -1.1 -0.3
Maternal smoking around birth 0.5 0.8 2.1 -1.5 0.2 -1.0 0.5 -0.7
Fed-up feelings 0.2 0.3 0.5 0.4 0.2 0.7 0.7 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 2.6 -0.2 -0.0 1.6 0.3 0.2
Relative age voice broke 0.8 1.2 2.9 -1.7 0.6 -1.1 -0.8 -1.0
Taking other prescription medications 1.3 2.0 4.2 1.8 -1.2 2.0 0.8 0.6
Age when periods started (menarche) 0.5 1.3 3.3 1.8 -0.8 0.3 -1.3 0.7
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 3.6 -0.6 -1.9 -0.1 1.8 1.0
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 8.3 2.9 -1.4 0.0 -0.0 0.8
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.3 -0.4 0.1 -0.7 1.1 -0.5
Qualifications: CSEs or equivalent 2.1 2.8 4.6 -2.1 -0.7 -2.0 1.4 -1.8
Serious illness, injury or assault to yourself 0.4 0.5 0.9 1.0 0.3 -0.8 -0.5 0.6
High blood pressure 0.3 0.8 1.7 -1.3 0.1 0.6 0.6 -1.1
Hayfever, allergic rhinitis or eczema 1.1 2.3 5.5 -1.5 1.9 0.2 -0.3 -2.3
Multivitamins +/- minerals 2.1 2.7 10.7 -0.3 -0.2 3.3 -0.7 -1.4
Stomach or abdominal pain in last month 1.4 1.8 6.3 -0.7 0.9 2.5 0.1 -1.1
Supplements: Glucosamine 1.7 2.2 4.6 2.2 -1.5 0.4 -1.8 0.9
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.6 -0.7 -0.3 -1.1 -1.3 -0.3
Medication: Atenolol 0.6 0.7 2.1 0.1 -0.3 0.8 -1.4 -0.9
Medication: Levothyroxine sodium 2.6 4.4 10.6 1.0 -1.5 2.8 0.5 3.2
Sitting height 0.2 1.3 3.6 1.9 -1.6 0.0 0.3 0.3
Chronic bronchitis/emphysema (father) 0.4 0.5 1.1 0.5 -0.5 -0.8 1.1 -0.3
High blood pressure (mother) 0.9 1.2 5.1 -0.7 0.5 -0.1 0.3 -2.3
Body mass index (BMI) 0.4 1.8 3.8 -1.3 0.6 -1.3 -1.4 -1.9
Impedance of leg (left) 1.0 4.9 10.0 3.2 0.4 2.7 0.4 2.6
Leg predicted mass (left) 0.8 4.0 8.7 -2.4 0.4 -2.4 0.1 -3.0
Trunk fat mass 0.1 0.4 1.1 0.3 0.5 0.3 -1.0 -0.7
Waist circumference 0.2 0.6 1.1 -0.7 0.5 -0.7 -1.0 -0.9
Number of incorrect matches in round 1.7 2.9 6.1 0.6 -2.5 -0.9 2.5 1.1
Past tobacco smoking 0.8 1.5 5.6 -0.4 1.1 0.1 -0.7 -2.4
Alcohol usually taken with meals 0.8 1.3 2.9 -0.7 0.9 1.7 -1.5 0.4
Nervous feelings 1.4 2.7 4.4 2.0 -0.9 2.1 0.0 2.0
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.7 10.8 1.7 -0.9 3.3 0.5 1.9
Hearing difficulty/problems with background noise 0.4 0.7 2.2 -1.5 -0.2 0.4 0.8 -0.6
Hair/balding pattern: Pattern 2 0.4 0.5 0.9 0.9 0.3 -0.8 -0.2 -1.0
Had menopause 4.6 5.8 13.0 1.9 -2.0 3.6 -1.0 2.6
Had other major operations 0.5 0.6 1.8 -0.7 -0.6 -0.1 -1.3 -0.3
Forced vital capacity (FVC) 0.4 1.6 4.5 -1.8 0.1 -2.1 -0.3 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 5.9 2.4 -0.6 0.2 -0.3 0.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.0 -0.6 0.2 1.4 0.9 -0.4
Qualifications: None of the above 0.8 1.6 3.7 1.3 -1.6 -0.1 0.4 1.9
Financial difficulties in last 2 years 0.3 0.3 1.3 0.6 0.1 -0.3 1.1 0.1
Mouth/teeth dental problems 0.7 1.1 3.4 -0.1 1.1 -0.3 -1.8 -0.8
Heart attack 1.2 1.5 5.3 0.2 0.7 2.3 1.4 0.2
Allergy 0.7 1.6 4.1 1.1 -1.5 -0.7 -0.1 2.0
Pain all over the body in last month 0.4 0.5 1.3 -0.4 0.5 0.7 0.2 1.1
Diabetes (self-reported) 0.1 0.2 0.5 -0.3 -0.1 -0.4 -0.3 0.7
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 3.2 -0.3 0.3 -0.0 -0.7 -1.8
Medication: Ramipril 0.1 0.1 0.3 0.1 -0.0 -0.3 0.6 0.3
Medication: Simvastatin 0.9 1.4 2.8 -0.3 1.2 -1.7 1.1 -1.2
Fluid intelligence score 0.6 1.3 5.5 -0.3 2.3 0.2 0.8 -0.1
Illnesses of siblings 0.6 0.8 2.8 -0.1 0.2 0.9 -1.7 0.4
Neuroticism score 2.0 4.3 11.0 1.1 -1.2 3.3 2.4 1.4
Weight 0.3 1.3 3.0 -1.0 0.6 -1.2 -0.9 -1.7
Impedance of arm (right) 0.9 4.1 7.3 2.6 -0.2 2.7 0.1 2.5
Arm fat percentage (right) 0.1 0.5 1.6 -0.2 0.5 0.2 -1.3 -0.9
Trunk fat-free mass 0.5 3.0 6.1 -2.1 -0.1 -2.5 0.1 -2.1
Hip circumference 0.5 2.4 4.9 -1.3 1.6 -1.0 -1.3 -2.2
Time employed in main current job 0.2 0.2 0.4 0.3 0.5 -0.2 0.6 0.4
Alcohol intake versus 10 years previously 0.4 0.5 1.4 -0.3 0.2 0.0 1.1 -1.2
Father’s age at death 0.3 0.4 0.7 -0.8 0.3 0.5 -0.9 0.2
Worrier / anxious feelings 4.2 8.0 17.6 3.0 -3.0 4.2 0.1 2.0
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 3.9 1.5 -0.4 2.0 0.1 1.8
Falls in the last year 1.0 1.4 1.9 1.1 -1.1 1.3 1.4 -0.9
Hair/balding pattern: Pattern 3 0.9 1.3 3.5 0.6 -0.4 1.4 0.8 1.9
Number of live births 0.3 0.5 0.9 -1.0 -0.2 -0.6 0.4 0.9
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 8.3 -2.3 0.2 -2.9 -0.4 -0.2
Pulse rate 0.5 0.9 3.5 0.4 -0.4 0.8 0.1 1.9
Happiness 0.9 1.0 2.6 0.8 1.0 -0.4 1.6 0.9
Noisy workplace 0.3 0.3 1.2 -0.3 1.1 -0.1 -0.1 0.6
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.1 -0.7 1.1 0.3 -0.7 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.3 -1.2 -0.2 0.2 1.1 -0.8
Mouth/teeth dental problems: Dentures 1.2 2.0 5.8 -1.6 1.2 -0.4 2.4 -0.5
Asthma 0.6 1.1 2.2 0.4 1.2 1.1 -0.6 -1.5
Medication: Ibuprofen (e.g. Nurofen) 2.1 2.6 6.0 -2.5 2.0 -0.8 0.9 -1.4
Medication: Cholesterol lowering 1.5 2.3 7.7 0.3 1.2 1.4 2.8 -0.2
Depression (self-reported) 0.7 0.9 1.3 -0.6 1.2 0.9 -0.8 1.1
Medication: Lansoprazole 1.5 1.7 3.5 1.6 0.6 -1.5 0.3 -1.9
Prospective memory result 0.7 0.9 1.9 -0.6 -1.2 -1.4 -0.7 0.2
Lung cancer (father) 1.2 1.5 2.8 -1.7 1.2 -1.1 0.3 -1.2
Illnesses of mother 0.5 0.6 2.3 -1.5 -0.2 0.2 0.5 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 3.7 -1.9 0.5 -1.9 -0.0 -0.1
Pulse wave Arterial Stiffness index 0.9 1.0 3.2 0.4 -1.1 -0.4 -0.6 1.8
Impedance of arm (left) 1.0 4.7 9.0 2.6 -0.2 3.0 0.5 2.8
Arm fat mass (right) 0.3 1.0 2.6 -0.7 0.3 -0.6 -1.3 -1.6
Trunk predicted mass 0.5 2.9 6.2 -2.1 -0.2 -2.5 0.1 -2.0
Standing height 0.0 0.3 0.5 0.7 -0.4 0.2 0.7 0.6
Length of working week for main job 1.0 1.1 3.1 -1.8 0.8 -0.8 -0.4 -1.0
Exposure to tobacco smoke at home 1.9 2.2 5.0 2.2 -1.9 -0.3 -0.9 1.1
Breastfed as a baby 1.2 1.4 2.1 -0.3 -1.4 1.5 1.0 1.4
Tense / ‘highly strung’ 1.4 2.3 3.9 0.9 -1.0 2.0 1.5 1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.5 3.8 7.9 0.7 -2.8 0.7 1.9 2.5
Hair/balding pattern: Pattern 4 0.3 0.7 1.5 0.2 0.8 -1.2 -0.9 -0.7
Birth weight of first child 0.8 1.4 5.1 0.5 -0.1 2.3 -0.5 1.2
Peak expiratory flow (PEF) 1.3 3.0 7.4 -2.7 0.7 -2.7 0.1 -0.2
Pulse wave reflection index 0.1 0.2 0.3 -0.3 -0.3 0.5 -0.4 0.6
Ever highly irritable/argumentative for 2 days 0.9 1.0 2.3 -1.4 0.3 1.5 0.5 -0.6
Loud music exposure frequency 0.5 0.5 1.7 -0.2 -0.8 0.3 1.3 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.7 -0.8 0.8 0.1 -0.2 -0.2
Mouth/teeth dental problems: Bleeding gums 3.6 4.6 9.8 1.8 -2.6 1.7 -0.5 3.1
Blood clot in the leg (DVT) 0.8 1.1 2.8 0.8 -1.2 0.4 0.5 1.7
Medication: Paracetamol 0.1 0.1 0.3 0.2 -0.2 -0.5 0.4 -0.5
Headache pain in last month 0.9 1.5 3.3 1.8 -1.1 1.4 0.8 0.8
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 7.3 -0.1 -0.3 -0.8 -2.7 0.7
Glaucoma (self-reported) 0.2 0.2 0.5 0.5 0.7 0.5 0.0 0.3
Gout (self-reported) 0.6 0.9 2.7 0.6 0.1 -0.4 -1.6 -1.1
Hypothyroidism/myxoedema (self-reported) 3.2 6.3 14.0 1.6 -1.6 3.3 1.3 3.7
Medication: Amlodipine 0.3 0.5 1.2 -0.2 1.0 -0.2 1.1 0.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.1 0.5 0.2 0.3 -0.3 -1.5
Birth weight 0.6 1.3 2.5 -1.4 -0.0 0.6 -1.2 -1.6
Chronic bronchitis/emphysema (mother) 1.1 1.2 4.2 -0.9 1.1 0.0 -0.1 -2.0
High blood pressure (siblings) 0.8 1.2 3.0 0.2 -1.7 -1.2 1.1 0.8
Forced vital capacity (FVC), Best measure 0.4 1.6 3.6 -1.9 1.0 -1.6 0.8 -0.4
Body fat percentage 0.1 0.5 1.3 0.7 0.6 0.8 -1.1 -0.1
Leg fat percentage (right) 0.1 0.5 1.3 0.3 1.1 0.7 -0.7 -0.1
Arm fat-free mass (right) 0.6 3.3 5.9 -2.2 0.6 -2.3 0.3 -2.4
Exposure to tobacco smoke outside home 0.9 1.2 3.8 -2.0 0.5 -0.1 0.8 -1.0
Comparative body size at age 10 1.3 3.6 11.0 -2.0 -1.1 -3.3 -1.0 -0.8
Number of full brothers 0.9 1.2 3.2 -1.8 1.0 -0.7 1.1 -0.4
Worry too long after embarrassment 1.1 1.8 5.6 -1.5 0.3 2.4 0.4 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.6 5.8 0.6 -0.6 2.4 1.0 0.8
Wheeze or whistling in the chest in last year 0.3 0.5 1.6 -0.6 -0.4 0.6 0.3 -1.3
Number of children fathered 1.0 1.2 3.8 -0.0 0.5 1.3 -1.9 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.8 2.7 0.1 0.4 0.9 -1.6 -0.3
Age at first live birth 0.3 0.5 1.3 0.6 0.7 -1.1 0.3 0.6
Pulse wave peak to peak time 0.8 0.9 2.4 -0.4 1.2 0.4 0.7 -1.6
Health satisfaction 1.0 1.4 2.7 -0.5 1.6 -0.9 1.1 -1.4
Shortness of breath walking on level ground 0.6 0.7 2.4 -1.6 0.7 0.1 0.1 -0.9
Qualifications: College or University degree 0.8 2.6 8.0 -1.3 2.8 1.3 1.2 -0.3
Eye problems/disorders: None of the above 0.3 0.4 1.0 -0.8 0.0 1.0 -0.0 -0.6
Mouth/teeth dental problems: Loose teeth 1.9 2.2 3.7 1.9 -1.8 -0.4 1.4 1.5
Emphysema/chronic bronchitis 1.5 1.7 3.7 -1.9 1.1 -0.9 1.4 -0.9
Medication for pain relief, constipation, heartburn 0.2 0.3 0.6 0.1 0.8 0.1 -0.7 0.8
Neck or shoulder pain in last month 0.5 0.8 2.0 0.4 -0.7 -0.3 -1.0 -1.4
Medication: Blood pressure 0.5 0.8 2.5 -0.4 0.3 0.9 1.6 -0.6
Angina (self-reported) 0.3 0.4 1.0 0.3 0.6 -1.0 0.6 -0.5
Migraine (self-reported) 0.3 0.4 1.4 -0.1 -1.2 0.5 -0.3 0.3
Medication: Ibuprofen 1.9 2.3 7.1 -2.7 0.9 -0.2 1.6 -0.9
Medication: Allopurinol 0.3 0.3 1.1 0.5 -0.1 -0.4 -1.1 -0.4
Medication: Omeprazole 1.4 1.6 3.2 1.8 -0.9 1.7 0.6 1.0
Medication: Seretide 50 evohaler 0.8 0.9 2.3 -0.2 1.5 -0.3 -0.9 -1.1
Mean time to correctly identify matches 0.5 1.0 2.8 0.1 -0.7 0.9 0.8 1.7
Heart disease (mother) 1.1 1.4 5.5 2.3 -0.7 0.6 0.6 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.1 1.1 -0.3 -0.2 -0.7 -1.0
Whole body fat mass 0.1 0.6 1.3 -0.3 0.6 -0.1 -1.2 -1.0
Leg fat mass (right) 0.1 0.4 0.7 -0.4 0.8 -0.3 -0.6 -0.8
Arm predicted mass (right) 0.6 3.2 6.1 -2.1 0.5 -2.3 -0.1 -2.5
Pulse rate, automated reading 0.3 1.0 2.8 -0.4 0.8 0.5 -0.9 1.7
Alcohol intake frequency. 0.2 0.4 0.9 0.2 -1.0 0.9 0.1 -0.6
Comparative height size at age 10 0.1 0.7 1.9 1.4 -0.5 -0.7 0.9 0.3
Number of full sisters 1.9 2.3 5.4 1.3 0.1 2.0 -0.8 2.3
Suffer from ‘nerves’ 1.7 2.6 7.4 0.6 -1.4 2.7 1.2 1.4
Overall health rating 0.7 1.4 3.6 -0.5 0.3 0.8 1.6 -1.9
Chest pain or discomfort 0.4 0.6 1.0 -0.2 1.0 0.2 -0.9 -1.0
Had major operations 0.1 0.1 0.6 -0.0 -0.1 0.2 -0.3 -0.8
Age at last live birth 0.3 0.4 1.0 0.4 0.4 0.1 1.0 0.9
Family relationship satisfaction 1.2 1.4 6.5 -0.3 -0.6 -0.3 2.5 0.4
Leg pain on walking 0.3 0.4 1.4 0.7 -0.3 0.2 1.2 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.3 0.2 0.3 -0.1 -1.1 0.2
Commuting to job workplace: Car/motor vehicle 2.1 2.4 7.1 0.7 1.0 -0.5 -2.7 -1.8
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.0 -1.0 -0.0 -0.1 -0.5 -0.9
Medication: Aspirin 0.3 0.4 1.0 0.4 -1.0 0.7 0.3 0.4
Supplements: Vitamin C 0.4 0.5 1.3 -0.0 -0.6 1.1 -0.9 0.2
Knee pain experienced in last month 0.4 0.6 2.7 0.0 -0.3 -1.6 -0.0 -0.3
Hypertension (Self-reported) 0.2 0.5 1.4 -1.2 -0.3 0.5 0.6 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.7 4.4 14.0 3.7 -1.0 0.9 2.4 0.5
Illnesses of father: Heart disease 0.5 0.7 1.5 0.4 1.0 -1.0 -1.2 0.1
Illnesses of siblings: Diabetes 0.2 0.2 0.4 0.6 -0.7 -0.2 0.1 0.2
Smoking status: Previous 1.1 1.7 4.8 1.2 -1.2 -0.3 0.7 2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 3.0 -0.3 0.1 -1.7 -0.3 -1.7
Whole body fat-free mass 0.7 3.9 7.1 -2.4 0.3 -2.5 0.1 -2.7
Leg fat-free mass (right) 0.9 4.6 9.9 -2.7 0.3 -2.4 0.0 -3.1
Arm fat percentage (left) 0.1 0.4 1.3 -0.3 0.4 0.5 -1.1 -0.6
Average weekly red wine intake 0.8 1.2 3.2 -1.8 1.2 1.1 0.3 0.5
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.9 -0.9 0.7 0.3 -0.5 0.2
Mood swings 1.1 2.0 3.8 1.2 -1.2 1.6 2.0 0.7
Loneliness, isolation 0.8 1.1 4.0 0.7 -0.1 2.0 1.1 -0.0
Long-standing illness, disability or infirmity 0.5 0.8 1.9 1.0 0.7 0.7 -0.5 -1.4
Ever had bowel cancer screening 2.0 2.4 7.8 1.4 -0.8 2.8 -0.7 0.9
Diabetes diagnosed by doctor 0.1 0.2 0.3 -0.5 0.3 -0.3 0.5 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.6 -0.9 0.6 -1.0 1.2 0.3
Friendships satisfaction 0.8 1.0 2.9 -0.1 0.2 1.4 1.7 0.5
Qualifications: nursing, teaching 0.4 0.7 1.4 0.5 0.6 0.8 -1.2 0.8
Commuting to job workplace: Walk 1.7 1.9 3.3 -0.7 -0.7 1.7 1.4 1.8
Eye problems/disorders: Cataract 0.8 1.0 3.0 0.6 -1.0 -1.7 0.3 0.7
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.7 -0.4 0.4 -0.1 1.3 -0.8
Medication for cholesterol 0.4 0.6 1.1 1.0 -1.1 1.0 0.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.5 3.1 -1.1 1.8 0.3 -1.4 -1.0
Back pain experienced in last month 0.7 1.0 1.7 1.3 -1.2 0.5 1.1 -0.6
Mineral and other dietary supplements 0.4 0.5 1.2 -0.8 0.6 -1.1 -0.5 -0.4
Breast cancer (self-reported) 0.2 0.3 0.5 -0.7 -0.3 0.6 -0.4 -0.4
Asthma (self-reported) 0.6 1.2 2.0 0.4 1.2 1.4 -0.7 -1.4
Osteoporosis (self-reported) 2.5 3.1 5.3 0.8 -2.2 2.3 -0.0 2.2
Osteoarthritis (self-reported) 1.0 1.3 4.2 2.0 -0.2 0.9 0.9 -0.7
Medication: Aspirin 0.2 0.2 0.9 0.1 -0.9 0.3 0.2 0.4
Medication: Gliclazide 0.6 0.7 1.6 -0.9 -0.4 -1.3 -0.3 -0.8
Illnesses of father: None of the above (group 1) 0.4 0.4 0.9 0.8 -0.3 0.5 0.6 -0.9
Smoking status: Current 1.8 2.9 10.7 -3.3 -0.2 -1.2 1.2 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.4 7.7 -1.7 0.2 -2.8 0.4 -1.0
Whole body water mass 0.7 4.0 7.1 -2.5 0.2 -2.6 0.1 -2.7
Leg predicted mass (right) 0.8 4.5 9.9 -2.6 0.3 -2.4 -0.0 -3.1
Arm fat mass (left) 0.2 0.8 1.8 -0.8 0.3 -0.5 -1.1 -1.4
Number of self-reported non-cancer illnesses 0.4 0.7 1.4 1.2 -1.1 0.4 0.5 -0.7
Average weekly champagne plus white wine intake 0.8 1.1 2.9 1.4 0.1 1.7 -0.7 0.4
Miserableness 1.2 2.0 6.4 0.1 0.4 2.5 1.9 -0.1
Guilty feelings 2.1 3.2 6.7 -1.0 -1.9 2.6 2.1 0.3
Wears glasses or contact lenses 1.5 1.7 3.0 1.7 -0.6 0.9 1.2 1.7
Ever taken oral contraceptive pill 2.1 2.3 6.0 -1.4 1.5 -2.5 0.7 -1.0
Hearing aid user 0.5 0.6 2.2 -0.5 -0.3 0.5 1.5 -0.1
Mother’s age at death 0.1 0.2 0.3 0.5 0.5 0.3 -0.4 0.3
Financial situation satisfaction 1.3 1.6 6.0 0.9 -0.0 0.6 2.5 0.8
Tinnitus: Yes, now most or all of the time 2.2 2.5 10.8 -1.1 -0.6 -0.3 3.3 -0.4
Commuting to job workplace: Public transport 1.8 2.2 5.9 -1.6 1.3 0.1 2.4 0.9
Eye problems/disorders: Glaucoma 0.2 0.3 0.9 0.5 -0.2 0.4 1.0 0.2
Medication: Blood pressure 0.3 0.6 1.2 -1.1 0.4 -0.3 -0.9 -0.9
Pain type(s) experienced in last month: Hip pain 2.3 2.9 10.0 1.5 1.3 3.2 -0.6 -0.1
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.1 1.4 -0.4 1.4 -0.1 0.4
High cholesterol (Self-reported) 0.5 0.9 3.2 0.5 0.6 -0.8 1.8 -0.5
Medication: Bendroflumethiazide 0.8 1.3 2.1 -1.4 0.6 0.7 -1.3 -1.3
Medication: Paracetamol 0.2 0.4 1.0 -0.3 0.4 -1.0 0.5 -0.6
Medication: Lisinopril 1.7 2.3 4.0 -2.0 1.3 -1.3 0.4 -1.9
Medication: Atorvastatin 3.2 4.0 7.9 1.7 -0.7 2.5 2.8 1.5
Illnesses of father: High blood pressure 0.6 0.8 2.2 -1.1 1.5 0.4 0.4 0.4
Alcohol drinker status: Never 0.6 0.7 1.3 -1.1 0.5 -0.8 0.5 -1.0
Ever smoked 1.2 2.2 5.0 -0.1 -1.7 -0.1 1.7 2.2
Basal metabolic rate 0.6 3.5 6.7 -2.2 0.3 -2.4 -0.1 -2.6
Leg fat percentage (left) 0.1 0.5 1.3 0.0 1.1 0.6 -1.0 -0.3
Arm fat-free mass (left) 0.6 2.8 5.6 -1.8 0.2 -2.3 -0.2 -2.4
Number of operations (self-reported) 1.2 1.8 3.6 -1.6 0.6 0.1 -1.6 -1.9
Average weekly beer plus cider intake 1.8 2.6 6.4 1.7 -1.0 -2.5 0.7 1.4
Irritability 2.0 3.4 7.3 2.7 -1.8 1.2 2.0 1.2
Risk taking 0.7 1.1 2.2 -1.4 0.5 -1.5 -0.1 -0.9
Ever had prostate specific antigen (PSA) test 1.9 2.2 9.3 0.1 -0.8 3.0 1.1 -0.3
Fractured/broken bones in last 5 years 1.3 1.7 4.2 2.1 -1.6 1.0 -0.4 -0.9
Age started oral contraceptive pill 1.1 1.3 2.3 1.5 0.4 1.4 -0.6 1.3
Diastolic blood pressure, automated reading 0.4 1.2 4.5 -0.6 -0.5 -0.9 2.1 -0.1
Ever depressed for a whole week 0.7 0.9 3.7 -0.5 -0.7 1.9 0.3 -0.2
Unable to work because of sickness or disability 1.8 2.3 4.6 2.1 -1.8 0.8 1.0 1.4
Commuting to job workplace: Cycle 1.6 1.9 4.1 -1.0 -0.6 -1.7 2.0 -1.2
Myopia 0.3 0.4 0.9 -0.9 0.8 0.5 0.0 0.5
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.3 1.4 -0.7 -0.8 -0.5 1.5
Cholesterol lowering medication 0.2 0.3 1.0 -0.3 0.3 -1.0 0.5 0.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.0 0.8 0.1 1.0 0.5 -0.1
Pain experienced in last month 0.3 0.6 1.5 0.1 -0.3 -1.1 -0.5 1.2
Supplements: Calcium 1.6 1.8 3.5 1.0 -1.4 1.9 -0.3 1.6
Basal cell carcinoma (self-reported) 0.7 0.9 2.1 -0.1 -0.2 0.4 -1.4 -1.4
Heart attack/myocardial infarction (self-reported) 1.2 1.5 5.4 0.4 0.4 2.3 1.3 0.3
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.4 0.8 -1.0 0.3 0.8 1.6
Heart disease (siblings) 1.4 1.7 3.5 -1.0 1.9 -0.6 -1.0 -1.7
Alcohol drinker status: Previous 1.4 1.6 3.6 1.5 -0.7 -1.9 1.2 -0.2
Pack years of smoking 0.7 1.1 2.7 0.4 -1.6 1.4 -0.0 0.7
Impedance of whole body 1.2 5.9 11.4 3.4 0.2 3.1 0.3 2.9
Leg fat mass (left) 0.1 0.6 1.3 -0.6 0.8 -0.2 -0.7 -1.1
Arm predicted mass (left) 0.6 3.0 6.2 -1.7 0.2 -2.5 -0.3 -2.5