Hub : Genes

C20orf108

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0400	0.0112	0.00002	0.032	0.020	0.029	0.03	0.031	1.1e-10	4.5e-07	1.1e-09	4.7e-10	2.4e-10
2	TCGA	Colon Adenocarcinoma	0.0950	0.0490	0.00170	0.052	0.021	0.030	NA	0.034	5.7e-04	2.1e-02	7.1e-03	NA	4.8e-03
3	TCGA	Brain Lower Grade Glioma	0.0719	0.0333	0.00940	0.000	0.008	0.002	NA	0.000	3.0e-01	4.1e-02	1.8e-01	NA	3.3e-01
4	TCGA	Pancreatic Adenocarcinoma	0.1780	0.0870	0.00230	0.062	0.088	0.063	NA	0.054	1.4e-03	1.5e-04	1.2e-03	NA	2.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	0.9	2.3	-1.5	0.4	0.1	1.0
Bipolar Disorder or Schizophrenia	1.4	3.4	6.9	-2.5	-0.3	0.7	2.6
Depressed Affect (Nagel 2018)	0.5	1.0	2.5	1.0	0.4	1.6	0.6
Depression (Nagel 2018)	0.1	0.2	0.5	0.4	-0.5	0.7	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.8	-0.2	1.7	-0.6	-1.2
Neuroticism (Nagel 2018)	0.2	0.5	0.8	0.7	0.6	0.9	0.7
Schizophrenia (2018)	1.3	2.7	5.9	-2.0	-0.7	0.6	2.4
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	0.5	0.2	-0.7	-0.4
Worry (Nagel 2018)	0.3	0.5	1.3	-0.1	0.9	0.1	1.1
Alzheimer’s Disease (in mother)	1.6	1.9	4.5	-0.6	1.5	-2.1	-0.7
Alzheimer’s Disease (in father)	1.9	2.0	4.9	-0.9	2.2	1.1	1.0
Alzheimer’s Disease (including proxy)	2.3	3.4	6.8	-1.0	2.6	-2.4	-0.5
Crohns Disease (2017)	1.8	4.0	6.3	-2.3	0.0	2.5	2.1
Irritable Bowel Disease (IBD)	1.7	4.0	7.8	-2.8	-1.0	1.7	2.1
Ulcerative Colitis (UC)	0.8	1.5	2.5	-1.6	-1.4	0.6	1.1
Major Depression (MDD)	1.4	1.7	3.1	-1.2	-1.5	-1.7	0.1
Reaction Time	0.2	0.3	0.5	-0.7	0.1	0.7	0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.2	-0.3	0.2	-0.7	-1.1
Breast Cancer	1.0	2.5	4.3	-1.5	-1.7	-2.1	0.6
Ovarian Cancer	0.7	0.9	2.9	-0.5	-0.8	-1.7	-0.2
Prostate Cancer	0.6	0.9	1.9	-0.6	1.4	1.1	-0.2
Age at First Birth	0.3	0.4	1.0	1.0	-0.1	-0.4	-0.7
Bipolar Disorder (2011)	0.6	0.6	2.3	0.0	0.0	-1.5	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.1
Coronary Artery Disease (CAD)	1.2	1.4	4.3	-2.1	0.7	-0.5	0.9
Crohns Disease (2012)	0.6	1.0	2.2	-1.0	-0.2	1.5	1.0
Mean Putamen Volume	2.3	2.6	4.6	1.7	1.6	-0.5	-2.1
Fasting Glucose	1.0	1.2	2.3	-0.9	1.5	1.3	0.3
HbA1C	1.3	1.5	5.2	-0.1	0.0	-2.3	-0.8
HDL Cholesterol	0.1	0.1	0.2	0.2	0.4	0.5	-0.1
LDL Cholesterol	0.8	1.2	2.7	0.9	-0.3	1.6	1.1
Lupus	0.6	0.9	3.0	0.2	-0.6	0.4	1.7
Neuroticism (2016)	0.9	1.3	4.5	0.2	2.1	0.8	-0.3
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.2	-0.5	0.3	0.6
Rheumatoid Arthritis	0.1	0.1	0.2	-0.4	0.2	0.2	0.4
Schizophrenia (2014)	1.1	2.4	6.3	-1.4	-1.0	0.5	2.5
Triglycerides	0.6	0.9	1.5	-1.0	-1.2	-0.4	1.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.4	0.2	-0.6	-0.3
Ulcerative Colitis	0.6	0.8	1.9	-1.4	-0.3	0.6	1.0
Blood Eosinophil Count	0.3	2.1	6.6	2.6	-0.3	-1.0	-0.7
Blood Platelet Count	0.6	7.3	21.4	-2.2	0.5	-4.6	1.6
Blood Red Count	0.2	1.8	2.1	1.5	-1.3	1.3	1.2
Blood White Count	0.1	0.8	1.7	-0.7	0.8	-0.4	1.3
Heel T-Score	0.0	0.3	0.7	-0.2	0.5	-0.8	-0.4
BMI	0.4	2.2	4.7	0.3	0.9	2.2	1.8
Height	1.3	24.6	38.7	4.2	-2.3	-6.2	-6.1
Waist Hip Ratio (WHR)	0.2	1.1	2.0	1.4	-0.2	1.4	-0.6
Systolic Blood Pressure	1.3	6.5	12.7	-3.1	0.3	1.9	3.6
Smoking Status	0.3	0.7	1.5	0.6	0.5	-0.8	-1.2
Allergy or Eczema	0.5	1.2	2.0	-0.3	1.4	1.4	0.9
Cardiovascular Disease	1.3	4.3	7.4	-2.0	-0.1	2.4	2.7
Hypothyroidism (self reported)	1.8	4.2	10.0	-1.6	0.1	3.2	2.1
Respiratory disease	0.1	0.2	0.3	0.6	0.5	-0.1	-0.4
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.6	-2.4	0.3	1.6	1.4
Lung FEV1/FVC ratio	0.7	3.3	11.0	0.7	-0.6	3.3	1.2
Lung FVC	0.1	0.5	1.7	-0.0	0.4	-1.3	-0.5
Neuroticism	0.1	0.3	0.7	0.8	0.0	0.5	0.7
Chronotype (morning person)	0.2	0.5	2.1	0.0	-1.4	0.2	-0.2
Hair Pigment	0.0	0.3	0.8	0.9	-0.3	0.2	-0.5
Tanning	0.1	0.6	1.3	-1.1	0.8	-0.5	0.6
Hand grip strength (left)	0.3	0.7	1.8	1.4	-0.9	0.2	-0.5
Number of treatments/medications taken	0.3	0.5	1.3	0.8	0.1	1.1	0.3
Average weekly spirits intake	0.4	0.5	1.1	-0.5	1.0	0.5	0.7
Sensitivity / hurt feelings	0.1	0.2	0.7	-0.9	0.1	0.4	0.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	-0.5	-0.1	0.8	0.8
Hearing difficulty/problems: Yes	0.8	1.2	2.8	1.7	-0.9	-0.3	-1.1
Relative age of first facial hair	2.0	4.2	15.2	0.9	-3.9	-0.5	-0.6
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.9	2.2	-0.2	-0.5	-2.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-0.7	1.0	0.8	0.4
Ever had hysterectomy (womb removed)	5.9	6.7	10.9	-2.6	1.3	3.3	2.7
Systolic blood pressure, automated reading	1.6	4.5	8.2	-1.7	0.3	2.9	2.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	0.5	0.4	0.7	-1.0
Angina	0.4	0.5	0.9	0.5	0.9	-0.8	0.4
Medication for hormone replacement therapy	0.6	0.6	1.7	-0.6	1.3	-0.7	-0.0
Vitamin and mineral supplements	0.3	0.4	0.8	-0.6	-0.6	0.2	0.9
Supplements: Zinc	1.1	1.2	2.8	-1.7	-1.0	-0.1	0.9
Medication: Co-codamol	0.2	0.3	0.5	0.7	0.6	0.3	-0.1
Medication: Metformin	0.5	0.7	1.6	0.3	-0.2	1.3	-1.1
Diabetes (father)	0.6	0.8	1.8	-1.3	-0.5	0.2	1.0
Diabetes (mother)	0.1	0.1	0.3	0.5	0.0	0.5	-0.2
Severe depression (siblings)	1.1	1.2	2.3	-0.0	1.5	1.4	-0.9
Pack years adult smoking proportion	1.4	2.2	5.2	-0.9	0.2	2.3	1.6
Impedance of leg (right)	0.2	0.8	2.6	-0.3	1.6	0.1	0.8
Leg fat-free mass (left)	0.8	4.3	7.1	2.2	-1.4	-1.9	-2.7
Trunk fat percentage	0.1	0.3	0.5	0.7	0.7	-0.2	0.4
Hand grip strength (right)	0.1	0.2	0.5	0.7	-0.1	0.3	-0.1
Townsend deprivation index at recruitment	1.9	2.7	5.6	-1.0	1.7	2.4	1.1
Current tobacco smoking	0.4	0.7	1.0	1.0	-0.9	-0.3	-1.0
Average weekly fortified wine intake	0.4	0.4	1.1	0.8	-0.1	0.1	-1.1
Maternal smoking around birth	1.3	1.9	4.3	-0.0	-1.8	-2.1	-0.3
Fed-up feelings	0.5	1.0	2.5	0.3	0.8	1.6	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.8	-0.5	0.8	0.2
Relative age voice broke	0.5	0.8	1.8	1.2	-1.4	0.1	0.2
Taking other prescription medications	0.1	0.1	0.3	-0.3	-0.2	0.2	0.5
Age when periods started (menarche)	1.7	4.1	9.3	2.4	-3.0	0.1	-1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.5	-0.9	-0.2	1.2	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.7	-1.3	-0.3	-0.8	0.8
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.7	1.0	1.5	-0.8	-1.6
Qualifications: CSEs or equivalent	0.8	1.0	2.2	1.5	-0.1	-0.3	-1.3
Serious illness, injury or assault to yourself	2.7	3.2	6.2	2.5	0.4	-0.8	-2.4
High blood pressure	0.7	2.0	3.0	-1.7	0.2	1.7	1.5
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.2	-0.1	1.3	1.5	1.4
Multivitamins +/- minerals	0.5	0.6	0.9	0.9	0.3	0.9	-0.7
Stomach or abdominal pain in last month	0.5	0.6	1.4	-0.0	-0.3	-1.2	-0.9
Supplements: Glucosamine	0.5	0.7	1.0	0.5	1.0	-0.7	-1.0
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	4.3	-2.1	1.5	1.1	1.6
Medication: Atenolol	0.5	0.6	1.3	-0.3	-1.1	0.4	0.9
Medication: Levothyroxine sodium	0.3	0.4	0.9	-0.4	-0.6	1.0	0.6
Sitting height	1.5	10.4	19.4	2.3	-0.4	-4.4	-4.1
Chronic bronchitis/emphysema (father)	0.7	0.8	1.9	-0.1	-0.9	0.8	1.4
High blood pressure (mother)	0.5	0.7	2.2	-1.5	0.4	0.1	0.7
Body mass index (BMI)	0.1	0.5	1.0	0.3	0.2	1.0	0.9
Impedance of leg (left)	0.1	0.4	0.7	-0.2	0.8	-0.8	0.7
Leg predicted mass (left)	0.9	4.5	7.6	2.2	-1.3	-2.0	-2.8
Trunk fat mass	0.2	0.9	2.2	1.5	0.1	-0.8	-0.8
Waist circumference	0.3	1.2	4.0	2.0	-0.4	0.4	-0.8
Number of incorrect matches in round	0.1	0.1	0.3	0.5	0.4	0.0	-0.2
Past tobacco smoking	0.1	0.2	0.6	-0.1	0.0	-0.8	0.1
Alcohol usually taken with meals	0.3	0.5	1.0	1.0	0.2	-0.5	-0.9
Nervous feelings	0.8	1.5	3.4	0.2	0.9	1.8	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	0.5	0.9	1.0	-0.1
Hearing difficulty/problems with background noise	1.1	1.8	3.7	1.9	0.6	1.0	-1.4
Hair/balding pattern: Pattern 2	0.6	0.7	1.7	-1.3	-0.7	-0.6	0.6
Had menopause	1.0	1.2	4.0	-0.5	0.2	2.0	0.9
Had other major operations	0.6	0.7	1.5	0.1	1.2	-0.8	-0.9
Forced vital capacity (FVC)	1.9	7.2	18.0	1.8	-0.2	-4.2	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.3	-0.8	0.2	-1.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	-0.4	-0.5	1.4	0.8
Qualifications: None of the above	0.2	0.5	1.7	0.3	-0.0	1.3	0.2
Financial difficulties in last 2 years	0.2	0.3	0.7	0.3	-0.8	-0.6	-0.1
Mouth/teeth dental problems	0.2	0.4	1.0	-1.0	-0.5	0.3	0.3
Heart attack	0.1	0.2	0.5	-0.1	-0.2	0.2	0.7
Allergy	0.3	0.7	0.9	-0.9	-0.7	-0.9	-0.6
Pain all over the body in last month	1.0	1.0	3.5	1.9	-0.4	0.3	-0.5
Diabetes (self-reported)	0.3	0.4	1.4	0.3	-0.2	1.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.6	0.2	-0.8	0.4
Medication: Ramipril	1.1	1.4	3.8	-0.9	1.9	1.1	0.1
Medication: Simvastatin	1.6	2.4	5.5	-1.0	-0.6	2.3	1.6
Fluid intelligence score	0.3	0.6	1.4	0.2	1.2	0.1	-1.1
Illnesses of siblings	0.9	1.2	3.6	-1.0	-1.9	-0.5	0.0
Neuroticism score	0.2	0.4	0.9	0.5	0.1	0.7	1.0
Weight	0.4	2.2	3.9	2.0	-0.3	-1.4	-1.6
Impedance of arm (right)	0.2	0.9	2.9	-0.2	0.9	-1.7	0.0
Arm fat percentage (right)	0.1	0.3	0.7	0.3	0.7	0.1	0.9
Trunk fat-free mass	1.1	6.1	11.4	2.5	-1.3	-2.3	-3.4
Hip circumference	0.3	1.2	3.3	1.8	-0.0	-1.0	-0.8
Time employed in main current job	0.4	0.5	1.0	0.6	-1.0	-0.7	-0.2
Alcohol intake versus 10 years previously	0.6	0.9	2.4	-1.6	0.0	-0.1	1.1
Father’s age at death	1.0	1.3	2.0	1.2	1.3	0.2	-1.4
Worrier / anxious feelings	0.2	0.4	0.9	-0.5	0.9	-0.0	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.5	1.6	0.0	0.7	-0.5
Falls in the last year	0.4	0.6	2.0	-0.3	0.4	-1.4	-0.1
Hair/balding pattern: Pattern 3	1.6	2.3	6.0	-0.5	1.4	2.4	1.1
Number of live births	0.9	1.3	3.1	-1.2	-0.3	0.6	1.8
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	9.7	1.8	-0.7	-3.1	-2.1
Pulse rate	1.5	2.5	5.6	-1.0	-1.0	1.6	2.4
Happiness	0.1	0.1	0.2	-0.4	0.4	-0.4	0.3
Noisy workplace	1.4	1.8	4.4	-0.3	-0.7	1.5	2.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.2	1.1	0.2	-0.7	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	1.0	-0.4	0.5	-0.2
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	0.1	0.9	0.9	0.7
Asthma	0.1	0.3	0.5	0.7	0.7	-0.2	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.0	1.7	-0.4	-0.9	0.4
Medication: Cholesterol lowering	1.6	2.5	4.8	-2.2	0.1	1.1	2.0
Depression (self-reported)	0.5	0.6	1.2	-1.1	0.2	-0.2	1.0
Medication: Lansoprazole	0.5	0.6	0.8	0.7	-0.7	-0.9	-0.9
Prospective memory result	1.5	1.9	5.1	-0.8	-2.3	0.4	1.2
Lung cancer (father)	0.2	0.2	0.6	0.3	-0.8	-0.0	-0.2
Illnesses of mother	0.2	0.2	0.4	0.6	-0.0	0.6	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	7.1	2.7	-1.4	-2.6	-1.8
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.1	0.3	-0.2	0.0
Impedance of arm (left)	0.2	0.8	2.8	-0.1	0.4	-1.7	0.2
Arm fat mass (right)	0.1	0.5	1.1	1.0	0.2	-0.8	-0.3
Trunk predicted mass	1.0	5.8	10.8	2.4	-1.2	-2.3	-3.3
Standing height	1.7	16.5	26.2	3.5	-1.3	-5.1	-5.0
Length of working week for main job	0.6	0.7	1.9	1.4	0.3	0.8	-0.4
Exposure to tobacco smoke at home	2.8	3.1	5.2	-1.9	-0.2	1.9	2.3
Breastfed as a baby	1.0	1.2	2.6	0.8	0.4	-1.3	-1.6
Tense / ‘highly strung’	0.2	0.3	0.8	-0.2	-0.1	0.4	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.0	-1.0	-0.9	-0.5	0.3
Hair/balding pattern: Pattern 4	0.2	0.4	0.6	0.4	-0.7	0.7	0.6
Birth weight of first child	0.9	1.7	6.2	-0.3	-2.5	-0.5	0.6
Peak expiratory flow (PEF)	1.4	3.1	5.4	1.6	-0.9	-2.3	-2.0
Pulse wave reflection index	0.2	0.3	0.5	0.5	0.7	0.0	-0.5
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.4	-0.7	-0.6	1.0	1.2
Loud music exposure frequency	0.5	0.6	1.4	1.0	0.1	-0.3	-1.2
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	3.1	-0.7	-1.8	-1.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.7	1.3	0.3	0.6	-0.8
Blood clot in the leg (DVT)	0.2	0.3	0.6	-0.3	-0.5	-0.7	-0.5
Medication: Paracetamol	1.3	2.1	6.8	2.6	0.5	-0.5	-1.0
Headache pain in last month	0.6	1.0	2.7	0.3	1.0	-1.6	-0.6
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	5.0	2.2	0.4	-0.8	-1.8
Glaucoma (self-reported)	0.8	0.9	2.1	1.2	0.1	0.2	-1.4
Gout (self-reported)	0.9	1.2	2.4	-1.1	-1.5	-1.2	0.2
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.3	-1.8	-0.3	1.6	1.5
Medication: Amlodipine	0.1	0.2	0.4	0.0	-0.6	0.3	0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.0	0.5	0.3	-1.4	-0.4
Birth weight	1.1	2.4	7.2	-2.7	0.0	-1.0	1.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.9	-0.1	-0.7	-1.4	-0.2
High blood pressure (siblings)	0.4	0.6	2.0	0.0	1.4	-0.5	0.3
Forced vital capacity (FVC), Best measure	1.9	7.0	14.1	2.6	-0.8	-3.8	-2.5
Body fat percentage	0.1	0.4	0.7	0.5	0.8	0.3	0.7
Leg fat percentage (right)	0.2	0.8	1.3	0.5	0.9	1.1	0.9
Arm fat-free mass (right)	0.8	3.9	6.9	2.4	-1.0	-1.4	-2.6
Exposure to tobacco smoke outside home	0.5	0.6	1.2	1.1	0.1	-0.9	-0.6
Comparative body size at age 10	1.6	4.3	7.2	-2.7	-1.6	-2.5	1.1
Number of full brothers	0.5	0.7	1.5	-0.6	1.2	0.9	0.4
Worry too long after embarrassment	0.6	1.0	2.3	1.0	-0.2	-0.9	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.1	0.9	0.6	0.8	-1.1
Wheeze or whistling in the chest in last year	0.5	0.8	1.9	1.4	1.2	0.1	0.0
Number of children fathered	0.7	0.8	1.4	0.3	-0.5	-1.2	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.5	-1.6	-0.2	-0.7	-0.2
Age at first live birth	0.6	1.0	3.0	0.4	-0.0	-1.7	-0.9
Pulse wave peak to peak time	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.4
Health satisfaction	0.2	0.2	0.7	-0.2	-0.0	-0.9	0.5
Shortness of breath walking on level ground	0.3	0.4	0.8	0.3	-0.2	0.9	0.7
Qualifications: College or University degree	0.2	0.5	0.8	0.9	-0.7	-0.6	-0.6
Eye problems/disorders: None of the above	1.2	1.4	5.0	-0.6	0.1	-2.2	-0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.1	-0.7	-0.1	-1.0	0.2
Emphysema/chronic bronchitis	0.5	0.6	1.0	0.7	-1.0	0.4	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	1.8	-1.3	0.3	-0.0	-0.4
Neck or shoulder pain in last month	2.5	3.6	5.6	-2.0	1.9	-1.0	2.4
Medication: Blood pressure	1.2	2.1	4.7	-2.2	-0.7	0.3	1.8
Angina (self-reported)	0.3	0.4	0.9	0.3	0.9	-0.5	0.5
Migraine (self-reported)	1.7	2.2	6.3	-0.3	-2.5	-1.5	0.3
Medication: Ibuprofen	0.8	1.0	3.7	1.9	0.1	-0.2	-0.3
Medication: Allopurinol	1.4	1.8	5.5	-0.5	-2.4	-1.3	-0.0
Medication: Omeprazole	0.3	0.4	0.7	-0.6	0.5	0.3	0.8
Medication: Seretide 50 evohaler	1.5	1.7	4.7	0.6	-0.7	-2.2	-1.1
Mean time to correctly identify matches	1.2	2.2	4.7	-1.1	0.5	2.2	1.6
Heart disease (mother)	0.6	0.8	1.8	0.4	1.4	1.0	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.8	0.8	1.3	0.6	-0.6
Whole body fat mass	0.1	0.5	1.2	1.1	0.4	-0.6	-0.4
Leg fat mass (right)	0.1	0.5	1.4	1.2	0.6	0.1	-0.4
Arm predicted mass (right)	0.7	3.8	6.8	2.1	-1.1	-1.7	-2.6
Pulse rate, automated reading	1.0	3.2	7.9	-0.1	0.4	2.8	2.2
Alcohol intake frequency.	0.0	0.0	0.2	0.4	-0.0	0.2	-0.0
Comparative height size at age 10	2.9	16.1	31.5	2.3	0.5	-5.6	-5.2
Number of full sisters	0.8	0.9	2.9	1.7	0.2	-0.3	-0.8
Suffer from ‘nerves’	0.2	0.4	0.7	0.5	0.8	0.5	0.7
Overall health rating	0.2	0.5	0.8	0.9	-0.9	-0.7	-0.1
Chest pain or discomfort	3.4	4.9	13.3	3.6	0.1	0.7	-2.4
Had major operations	0.2	0.3	0.9	0.2	-0.9	-0.2	0.4
Age at last live birth	0.1	0.2	0.7	-0.1	0.3	-0.8	-0.1
Family relationship satisfaction	0.6	0.7	2.0	-1.4	-0.0	-0.5	0.9
Leg pain on walking	0.2	0.2	0.7	0.8	-0.3	-0.1	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.6	0.4	1.3	-1.2	-1.2
Commuting to job workplace: Car/motor vehicle	1.6	1.9	5.1	-0.1	-2.3	-1.5	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	-0.8	0.7	-0.2	0.5
Medication: Aspirin	0.9	1.1	2.4	0.1	0.2	1.5	1.5
Supplements: Vitamin C	0.4	0.4	1.1	-0.6	0.1	-1.0	-0.6
Knee pain experienced in last month	0.6	1.0	1.4	1.2	0.2	-1.2	-1.0
Hypertension (Self-reported)	0.8	2.2	3.5	-1.9	0.1	1.7	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.8	0.2	-0.8	-1.7	-1.3
Illnesses of father: Heart disease	0.2	0.3	0.9	-0.4	0.4	-1.0	-0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.3	0.3	0.0	-0.0
Smoking status: Previous	0.2	0.3	0.6	-0.6	0.1	0.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted	4.8	10.0	18.6	2.8	-1.2	-4.3	-3.5
Whole body fat-free mass	1.0	5.6	10.0	2.4	-1.4	-2.1	-3.2
Leg fat-free mass (right)	1.1	6.0	8.8	2.2	-1.9	-2.6	-3.0
Arm fat percentage (left)	0.1	0.3	0.6	0.5	0.4	0.1	0.8
Average weekly red wine intake	0.5	0.8	1.1	0.2	1.1	-0.9	-1.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.6	1.3	-0.9	-0.2	-0.8
Mood swings	0.2	0.3	0.7	0.5	0.1	0.7	0.8
Loneliness, isolation	1.0	1.4	2.2	-0.6	-1.5	1.3	1.2
Long-standing illness, disability or infirmity	0.7	1.1	2.6	1.6	0.5	0.1	-1.2
Ever had bowel cancer screening	2.8	3.2	6.5	-2.6	0.1	-0.8	2.4
Diabetes diagnosed by doctor	0.3	0.5	1.9	-0.2	0.2	1.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	6.2	2.5	-0.6	-1.5	-1.6
Friendships satisfaction	0.6	0.7	1.5	-0.6	0.4	0.9	1.2
Qualifications: nursing, teaching	0.8	1.2	1.9	1.4	-0.3	-1.0	-1.3
Commuting to job workplace: Walk	0.1	0.2	0.3	0.5	0.3	0.2	-0.5
Eye problems/disorders: Cataract	2.1	2.4	8.1	0.6	-0.2	2.8	1.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.8	0.1	-2.0	-1.2	0.3
Medication for cholesterol	0.1	0.1	0.2	-0.4	-0.3	0.0	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.7	0.8	1.2	1.6	-0.6
Back pain experienced in last month	0.6	0.8	1.5	-0.7	1.2	0.3	1.0
Mineral and other dietary supplements	0.4	0.5	1.3	0.6	0.5	-1.1	-0.1
Breast cancer (self-reported)	0.4	0.5	1.1	0.8	-0.2	0.2	-1.1
Asthma (self-reported)	0.2	0.3	0.8	0.4	0.9	-0.5	-0.1
Osteoporosis (self-reported)	1.5	1.9	3.0	-1.3	-1.7	0.9	1.5
Osteoarthritis (self-reported)	0.5	0.7	1.3	-0.5	1.0	0.6	1.1
Medication: Aspirin	1.4	1.8	4.1	-0.1	0.4	2.0	1.7
Medication: Gliclazide	0.8	0.8	2.7	-0.7	-1.6	-0.4	0.3
Illnesses of father: None of the above (group 1)	1.6	1.9	3.5	1.8	-0.1	0.9	-1.9
Smoking status: Current	0.4	0.6	1.1	1.0	-0.7	-0.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.1	1.1	0.6	-0.8	-1.0
Whole body water mass	1.0	5.5	10.0	2.4	-1.4	-2.1	-3.2
Leg predicted mass (right)	1.1	6.1	8.9	2.2	-1.9	-2.7	-3.0
Arm fat mass (left)	0.1	0.4	1.3	1.1	0.2	-0.5	-0.2
Number of self-reported non-cancer illnesses	0.6	1.0	2.5	-1.2	-0.1	0.2	1.6
Average weekly champagne plus white wine intake	0.3	0.5	1.2	0.5	1.1	0.5	-0.3
Miserableness	0.0	0.1	0.1	0.3	0.1	-0.3	-0.0
Guilty feelings	0.4	0.6	1.6	0.6	-1.3	-0.5	-0.5
Wears glasses or contact lenses	0.3	0.4	0.5	-0.6	-0.6	-0.7	-0.5
Ever taken oral contraceptive pill	0.7	0.8	1.1	-0.7	-0.8	-0.9	1.0
Hearing aid user	0.1	0.1	0.1	0.3	-0.3	0.0	-0.1
Mother’s age at death	0.9	1.1	2.1	-1.4	0.2	1.2	1.0
Financial situation satisfaction	0.5	0.6	1.1	-0.7	0.4	0.8	1.0
Tinnitus: Yes, now most or all of the time	1.5	1.8	5.1	-1.1	-0.9	-2.2	0.4
Commuting to job workplace: Public transport	0.7	0.9	1.9	0.8	1.4	0.4	-0.8
Eye problems/disorders: Glaucoma	0.8	1.0	1.7	1.3	-0.5	-0.5	-1.2
Medication: Blood pressure	0.5	0.9	1.5	-1.0	0.1	0.9	1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.1	1.7	-0.9	1.2	0.7	1.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	0.1	-1.2	0.6	-0.1
High cholesterol (Self-reported)	0.8	1.5	3.8	0.0	0.6	1.9	1.3
Medication: Bendroflumethiazide	0.5	0.7	2.5	-1.6	0.4	0.0	0.4
Medication: Paracetamol	2.3	3.6	8.2	2.9	1.0	-1.1	-2.0
Medication: Lisinopril	1.0	1.3	3.7	-1.2	-0.3	-0.2	1.9
Medication: Atorvastatin	0.9	1.1	2.2	1.3	1.5	-0.5	-0.4
Illnesses of father: High blood pressure	0.3	0.3	1.1	-0.2	0.1	-1.0	0.4
Alcohol drinker status: Never	0.6	0.8	1.0	1.0	-0.8	-0.8	-0.9
Ever smoked	0.3	0.5	1.2	0.7	-0.3	0.2	-1.1
Basal metabolic rate	1.0	5.3	9.1	2.5	-1.1	-2.2	-3.0
Leg fat percentage (left)	0.1	0.3	0.6	0.5	0.2	0.5	0.8
Arm fat-free mass (left)	0.7	3.3	5.7	2.1	-0.7	-1.5	-2.4
Number of operations (self-reported)	0.3	0.4	1.2	-0.3	0.0	-1.1	-0.5
Average weekly beer plus cider intake	0.3	0.5	1.6	0.4	-0.1	1.3	-0.2
Irritability	0.6	1.1	2.4	0.2	0.8	1.6	1.1
Risk taking	0.5	0.8	2.1	0.8	-1.4	0.2	0.6
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	-0.5	0.4	-0.5	0.1
Fractured/broken bones in last 5 years	0.6	0.7	2.2	-0.1	0.7	-1.5	-0.5
Age started oral contraceptive pill	1.0	1.2	4.4	-0.1	0.0	2.1	0.6
Diastolic blood pressure, automated reading	1.1	3.4	7.6	-1.4	0.1	2.0	2.8
Ever depressed for a whole week	0.4	0.6	1.0	-0.6	-1.0	-0.5	0.8
Unable to work because of sickness or disability	0.4	0.5	1.7	0.3	-0.2	-1.3	-0.5
Commuting to job workplace: Cycle	2.3	2.8	9.1	0.6	3.0	-0.7	-1.2
Myopia	0.9	1.3	2.6	0.7	0.1	-1.6	-1.4
Vascular/heart problems diagnosed by doctor	1.0	2.8	3.9	2.0	0.0	-1.8	-1.9
Cholesterol lowering medication	1.1	1.6	4.3	2.1	-0.8	1.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	-0.4	0.4	0.5	0.8
Pain experienced in last month	1.2	2.1	6.4	0.3	-2.5	1.3	-0.2
Supplements: Calcium	0.5	0.6	1.4	-1.2	-0.4	0.6	0.7
Basal cell carcinoma (self-reported)	1.5	1.8	4.6	1.2	1.2	2.1	0.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.9	-0.4	-0.1	0.3	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.6	-0.5	-0.8	-0.4
Heart disease (siblings)	0.8	1.0	2.8	1.1	1.7	0.1	-0.3
Alcohol drinker status: Previous	0.4	0.5	1.5	0.6	-0.1	1.2	-0.3
Pack years of smoking	1.6	2.4	5.4	-1.0	0.2	2.3	1.8
Impedance of whole body	0.1	0.6	1.0	-0.4	0.7	-1.0	0.8
Leg fat mass (left)	0.1	0.4	1.3	1.1	0.1	-0.2	-0.3
Arm predicted mass (left)	0.7	3.5	6.7	2.0	-0.6	-1.7	-2.6