Hub : Genes

C20orf108

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0400 0.0112 0.00002 0.032 0.020 0.029 0.03 0.031 1.1e-10 4.5e-07 1.1e-09 4.7e-10 2.4e-10
2 TCGA Colon Adenocarcinoma 0.0950 0.0490 0.00170 0.052 0.021 0.030 NA 0.034 5.7e-04 2.1e-02 7.1e-03 NA 4.8e-03
3 TCGA Brain Lower Grade Glioma 0.0719 0.0333 0.00940 0.000 0.008 0.002 NA 0.000 3.0e-01 4.1e-02 1.8e-01 NA 3.3e-01
4 TCGA Pancreatic Adenocarcinoma 0.1780 0.0870 0.00230 0.062 0.088 0.063 NA 0.054 1.4e-03 1.5e-04 1.2e-03 NA 2.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.6 0.9 2.3 -1.5 0.4 0.1 1.0
Bipolar Disorder or Schizophrenia 1.4 3.4 6.9 -2.5 -0.3 0.7 2.6
Depressed Affect (Nagel 2018) 0.5 1.0 2.5 1.0 0.4 1.6 0.6
Depression (Nagel 2018) 0.1 0.2 0.5 0.4 -0.5 0.7 0.1
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.8 -0.2 1.7 -0.6 -1.2
Neuroticism (Nagel 2018) 0.2 0.5 0.8 0.7 0.6 0.9 0.7
Schizophrenia (2018) 1.3 2.7 5.9 -2.0 -0.7 0.6 2.4
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 0.5 0.2 -0.7 -0.4
Worry (Nagel 2018) 0.3 0.5 1.3 -0.1 0.9 0.1 1.1
Alzheimer’s Disease (in mother) 1.6 1.9 4.5 -0.6 1.5 -2.1 -0.7
Alzheimer’s Disease (in father) 1.9 2.0 4.9 -0.9 2.2 1.1 1.0
Alzheimer’s Disease (including proxy) 2.3 3.4 6.8 -1.0 2.6 -2.4 -0.5
Crohns Disease (2017) 1.8 4.0 6.3 -2.3 0.0 2.5 2.1
Irritable Bowel Disease (IBD) 1.7 4.0 7.8 -2.8 -1.0 1.7 2.1
Ulcerative Colitis (UC) 0.8 1.5 2.5 -1.6 -1.4 0.6 1.1
Major Depression (MDD) 1.4 1.7 3.1 -1.2 -1.5 -1.7 0.1
Reaction Time 0.2 0.3 0.5 -0.7 0.1 0.7 0.5
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.2 -0.3 0.2 -0.7 -1.1
Breast Cancer 1.0 2.5 4.3 -1.5 -1.7 -2.1 0.6
Ovarian Cancer 0.7 0.9 2.9 -0.5 -0.8 -1.7 -0.2
Prostate Cancer 0.6 0.9 1.9 -0.6 1.4 1.1 -0.2
Age at First Birth 0.3 0.4 1.0 1.0 -0.1 -0.4 -0.7
Bipolar Disorder (2011) 0.6 0.6 2.3 0.0 0.0 -1.5 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 -0.4 -0.4 -0.4 0.1
Coronary Artery Disease (CAD) 1.2 1.4 4.3 -2.1 0.7 -0.5 0.9
Crohns Disease (2012) 0.6 1.0 2.2 -1.0 -0.2 1.5 1.0
Mean Putamen Volume 2.3 2.6 4.6 1.7 1.6 -0.5 -2.1
Fasting Glucose 1.0 1.2 2.3 -0.9 1.5 1.3 0.3
HbA1C 1.3 1.5 5.2 -0.1 0.0 -2.3 -0.8
HDL Cholesterol 0.1 0.1 0.2 0.2 0.4 0.5 -0.1
LDL Cholesterol 0.8 1.2 2.7 0.9 -0.3 1.6 1.1
Lupus 0.6 0.9 3.0 0.2 -0.6 0.4 1.7
Neuroticism (2016) 0.9 1.3 4.5 0.2 2.1 0.8 -0.3
Primary Biliary Cirrhosis 0.1 0.2 0.4 -0.2 -0.5 0.3 0.6
Rheumatoid Arthritis 0.1 0.1 0.2 -0.4 0.2 0.2 0.4
Schizophrenia (2014) 1.1 2.4 6.3 -1.4 -1.0 0.5 2.5
Triglycerides 0.6 0.9 1.5 -1.0 -1.2 -0.4 1.1
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.3 -0.4 0.2 -0.6 -0.3
Ulcerative Colitis 0.6 0.8 1.9 -1.4 -0.3 0.6 1.0
Blood Eosinophil Count 0.3 2.1 6.6 2.6 -0.3 -1.0 -0.7
Blood Platelet Count 0.6 7.3 21.4 -2.2 0.5 -4.6 1.6
Blood Red Count 0.2 1.8 2.1 1.5 -1.3 1.3 1.2
Blood White Count 0.1 0.8 1.7 -0.7 0.8 -0.4 1.3
Heel T-Score 0.0 0.3 0.7 -0.2 0.5 -0.8 -0.4
BMI 0.4 2.2 4.7 0.3 0.9 2.2 1.8
Height 1.3 24.6 38.7 4.2 -2.3 -6.2 -6.1
Waist Hip Ratio (WHR) 0.2 1.1 2.0 1.4 -0.2 1.4 -0.6
Systolic Blood Pressure 1.3 6.5 12.7 -3.1 0.3 1.9 3.6
Smoking Status 0.3 0.7 1.5 0.6 0.5 -0.8 -1.2
Allergy or Eczema 0.5 1.2 2.0 -0.3 1.4 1.4 0.9
Cardiovascular Disease 1.3 4.3 7.4 -2.0 -0.1 2.4 2.7
Hypothyroidism (self reported) 1.8 4.2 10.0 -1.6 0.1 3.2 2.1
Respiratory disease 0.1 0.2 0.3 0.6 0.5 -0.1 -0.4
Type 2 Diabetes (T2D) (2018) 1.4 2.6 5.6 -2.4 0.3 1.6 1.4
Lung FEV1/FVC ratio 0.7 3.3 11.0 0.7 -0.6 3.3 1.2
Lung FVC 0.1 0.5 1.7 -0.0 0.4 -1.3 -0.5
Neuroticism 0.1 0.3 0.7 0.8 0.0 0.5 0.7
Chronotype (morning person) 0.2 0.5 2.1 0.0 -1.4 0.2 -0.2
Hair Pigment 0.0 0.3 0.8 0.9 -0.3 0.2 -0.5
Tanning 0.1 0.6 1.3 -1.1 0.8 -0.5 0.6
Hand grip strength (left) 0.3 0.7 1.8 1.4 -0.9 0.2 -0.5
Number of treatments/medications taken 0.3 0.5 1.3 0.8 0.1 1.1 0.3
Average weekly spirits intake 0.4 0.5 1.1 -0.5 1.0 0.5 0.7
Sensitivity / hurt feelings 0.1 0.2 0.7 -0.9 0.1 0.4 0.2
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.7 -0.5 -0.1 0.8 0.8
Hearing difficulty/problems: Yes 0.8 1.2 2.8 1.7 -0.9 -0.3 -1.1
Relative age of first facial hair 2.0 4.2 15.2 0.9 -3.9 -0.5 -0.6
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 4.9 2.2 -0.2 -0.5 -2.0
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.0 -0.7 1.0 0.8 0.4
Ever had hysterectomy (womb removed) 5.9 6.7 10.9 -2.6 1.3 3.3 2.7
Systolic blood pressure, automated reading 1.6 4.5 8.2 -1.7 0.3 2.9 2.6
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.9 0.5 0.4 0.7 -1.0
Angina 0.4 0.5 0.9 0.5 0.9 -0.8 0.4
Medication for hormone replacement therapy 0.6 0.6 1.7 -0.6 1.3 -0.7 -0.0
Vitamin and mineral supplements 0.3 0.4 0.8 -0.6 -0.6 0.2 0.9
Supplements: Zinc 1.1 1.2 2.8 -1.7 -1.0 -0.1 0.9
Medication: Co-codamol 0.2 0.3 0.5 0.7 0.6 0.3 -0.1
Medication: Metformin 0.5 0.7 1.6 0.3 -0.2 1.3 -1.1
Diabetes (father) 0.6 0.8 1.8 -1.3 -0.5 0.2 1.0
Diabetes (mother) 0.1 0.1 0.3 0.5 0.0 0.5 -0.2
Severe depression (siblings) 1.1 1.2 2.3 -0.0 1.5 1.4 -0.9
Pack years adult smoking proportion 1.4 2.2 5.2 -0.9 0.2 2.3 1.6
Impedance of leg (right) 0.2 0.8 2.6 -0.3 1.6 0.1 0.8
Leg fat-free mass (left) 0.8 4.3 7.1 2.2 -1.4 -1.9 -2.7
Trunk fat percentage 0.1 0.3 0.5 0.7 0.7 -0.2 0.4
Hand grip strength (right) 0.1 0.2 0.5 0.7 -0.1 0.3 -0.1
Townsend deprivation index at recruitment 1.9 2.7 5.6 -1.0 1.7 2.4 1.1
Current tobacco smoking 0.4 0.7 1.0 1.0 -0.9 -0.3 -1.0
Average weekly fortified wine intake 0.4 0.4 1.1 0.8 -0.1 0.1 -1.1
Maternal smoking around birth 1.3 1.9 4.3 -0.0 -1.8 -2.1 -0.3
Fed-up feelings 0.5 1.0 2.5 0.3 0.8 1.6 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.6 0.8 -0.5 0.8 0.2
Relative age voice broke 0.5 0.8 1.8 1.2 -1.4 0.1 0.2
Taking other prescription medications 0.1 0.1 0.3 -0.3 -0.2 0.2 0.5
Age when periods started (menarche) 1.7 4.1 9.3 2.4 -3.0 0.1 -1.2
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.5 -0.9 -0.2 1.2 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 1.7 -1.3 -0.3 -0.8 0.8
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 2.7 1.0 1.5 -0.8 -1.6
Qualifications: CSEs or equivalent 0.8 1.0 2.2 1.5 -0.1 -0.3 -1.3
Serious illness, injury or assault to yourself 2.7 3.2 6.2 2.5 0.4 -0.8 -2.4
High blood pressure 0.7 2.0 3.0 -1.7 0.2 1.7 1.5
Hayfever, allergic rhinitis or eczema 0.7 1.4 2.2 -0.1 1.3 1.5 1.4
Multivitamins +/- minerals 0.5 0.6 0.9 0.9 0.3 0.9 -0.7
Stomach or abdominal pain in last month 0.5 0.6 1.4 -0.0 -0.3 -1.2 -0.9
Supplements: Glucosamine 0.5 0.7 1.0 0.5 1.0 -0.7 -1.0
Diverticular disease/diverticulitis (self-reported) 2.2 2.6 4.3 -2.1 1.5 1.1 1.6
Medication: Atenolol 0.5 0.6 1.3 -0.3 -1.1 0.4 0.9
Medication: Levothyroxine sodium 0.3 0.4 0.9 -0.4 -0.6 1.0 0.6
Sitting height 1.5 10.4 19.4 2.3 -0.4 -4.4 -4.1
Chronic bronchitis/emphysema (father) 0.7 0.8 1.9 -0.1 -0.9 0.8 1.4
High blood pressure (mother) 0.5 0.7 2.2 -1.5 0.4 0.1 0.7
Body mass index (BMI) 0.1 0.5 1.0 0.3 0.2 1.0 0.9
Impedance of leg (left) 0.1 0.4 0.7 -0.2 0.8 -0.8 0.7
Leg predicted mass (left) 0.9 4.5 7.6 2.2 -1.3 -2.0 -2.8
Trunk fat mass 0.2 0.9 2.2 1.5 0.1 -0.8 -0.8
Waist circumference 0.3 1.2 4.0 2.0 -0.4 0.4 -0.8
Number of incorrect matches in round 0.1 0.1 0.3 0.5 0.4 0.0 -0.2
Past tobacco smoking 0.1 0.2 0.6 -0.1 0.0 -0.8 0.1
Alcohol usually taken with meals 0.3 0.5 1.0 1.0 0.2 -0.5 -0.9
Nervous feelings 0.8 1.5 3.4 0.2 0.9 1.8 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.0 0.5 0.9 1.0 -0.1
Hearing difficulty/problems with background noise 1.1 1.8 3.7 1.9 0.6 1.0 -1.4
Hair/balding pattern: Pattern 2 0.6 0.7 1.7 -1.3 -0.7 -0.6 0.6
Had menopause 1.0 1.2 4.0 -0.5 0.2 2.0 0.9
Had other major operations 0.6 0.7 1.5 0.1 1.2 -0.8 -0.9
Forced vital capacity (FVC) 1.9 7.2 18.0 1.8 -0.2 -4.2 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.3 -0.8 0.2 -1.1 -0.1
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.8 -0.4 -0.5 1.4 0.8
Qualifications: None of the above 0.2 0.5 1.7 0.3 -0.0 1.3 0.2
Financial difficulties in last 2 years 0.2 0.3 0.7 0.3 -0.8 -0.6 -0.1
Mouth/teeth dental problems 0.2 0.4 1.0 -1.0 -0.5 0.3 0.3
Heart attack 0.1 0.2 0.5 -0.1 -0.2 0.2 0.7
Allergy 0.3 0.7 0.9 -0.9 -0.7 -0.9 -0.6
Pain all over the body in last month 1.0 1.0 3.5 1.9 -0.4 0.3 -0.5
Diabetes (self-reported) 0.3 0.4 1.4 0.3 -0.2 1.2 -0.5
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 -0.6 0.2 -0.8 0.4
Medication: Ramipril 1.1 1.4 3.8 -0.9 1.9 1.1 0.1
Medication: Simvastatin 1.6 2.4 5.5 -1.0 -0.6 2.3 1.6
Fluid intelligence score 0.3 0.6 1.4 0.2 1.2 0.1 -1.1
Illnesses of siblings 0.9 1.2 3.6 -1.0 -1.9 -0.5 0.0
Neuroticism score 0.2 0.4 0.9 0.5 0.1 0.7 1.0
Weight 0.4 2.2 3.9 2.0 -0.3 -1.4 -1.6
Impedance of arm (right) 0.2 0.9 2.9 -0.2 0.9 -1.7 0.0
Arm fat percentage (right) 0.1 0.3 0.7 0.3 0.7 0.1 0.9
Trunk fat-free mass 1.1 6.1 11.4 2.5 -1.3 -2.3 -3.4
Hip circumference 0.3 1.2 3.3 1.8 -0.0 -1.0 -0.8
Time employed in main current job 0.4 0.5 1.0 0.6 -1.0 -0.7 -0.2
Alcohol intake versus 10 years previously 0.6 0.9 2.4 -1.6 0.0 -0.1 1.1
Father’s age at death 1.0 1.3 2.0 1.2 1.3 0.2 -1.4
Worrier / anxious feelings 0.2 0.4 0.9 -0.5 0.9 -0.0 0.6
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.5 1.6 0.0 0.7 -0.5
Falls in the last year 0.4 0.6 2.0 -0.3 0.4 -1.4 -0.1
Hair/balding pattern: Pattern 3 1.6 2.3 6.0 -0.5 1.4 2.4 1.1
Number of live births 0.9 1.3 3.1 -1.2 -0.3 0.6 1.8
Forced expiratory volume in 1-second (FEV1) 1.3 4.4 9.7 1.8 -0.7 -3.1 -2.1
Pulse rate 1.5 2.5 5.6 -1.0 -1.0 1.6 2.4
Happiness 0.1 0.1 0.2 -0.4 0.4 -0.4 0.3
Noisy workplace 1.4 1.8 4.4 -0.3 -0.7 1.5 2.1
Qualifications: A levels/AS levels or equivalent 0.4 1.0 2.2 1.1 0.2 -0.7 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.9 1.0 -0.4 0.5 -0.2
Mouth/teeth dental problems: Dentures 0.3 0.5 0.8 0.1 0.9 0.9 0.7
Asthma 0.1 0.3 0.5 0.7 0.7 -0.2 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.0 1.7 -0.4 -0.9 0.4
Medication: Cholesterol lowering 1.6 2.5 4.8 -2.2 0.1 1.1 2.0
Depression (self-reported) 0.5 0.6 1.2 -1.1 0.2 -0.2 1.0
Medication: Lansoprazole 0.5 0.6 0.8 0.7 -0.7 -0.9 -0.9
Prospective memory result 1.5 1.9 5.1 -0.8 -2.3 0.4 1.2
Lung cancer (father) 0.2 0.2 0.6 0.3 -0.8 -0.0 -0.2
Illnesses of mother 0.2 0.2 0.4 0.6 -0.0 0.6 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.8 7.1 2.7 -1.4 -2.6 -1.8
Pulse wave Arterial Stiffness index 0.0 0.0 0.1 -0.1 0.3 -0.2 0.0
Impedance of arm (left) 0.2 0.8 2.8 -0.1 0.4 -1.7 0.2
Arm fat mass (right) 0.1 0.5 1.1 1.0 0.2 -0.8 -0.3
Trunk predicted mass 1.0 5.8 10.8 2.4 -1.2 -2.3 -3.3
Standing height 1.7 16.5 26.2 3.5 -1.3 -5.1 -5.0
Length of working week for main job 0.6 0.7 1.9 1.4 0.3 0.8 -0.4
Exposure to tobacco smoke at home 2.8 3.1 5.2 -1.9 -0.2 1.9 2.3
Breastfed as a baby 1.0 1.2 2.6 0.8 0.4 -1.3 -1.6
Tense / ‘highly strung’ 0.2 0.3 0.8 -0.2 -0.1 0.4 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.0 -1.0 -0.9 -0.5 0.3
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 0.4 -0.7 0.7 0.6
Birth weight of first child 0.9 1.7 6.2 -0.3 -2.5 -0.5 0.6
Peak expiratory flow (PEF) 1.4 3.1 5.4 1.6 -0.9 -2.3 -2.0
Pulse wave reflection index 0.2 0.3 0.5 0.5 0.7 0.0 -0.5
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.4 -0.7 -0.6 1.0 1.2
Loud music exposure frequency 0.5 0.6 1.4 1.0 0.1 -0.3 -1.2
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 3.1 -0.7 -1.8 -1.5 0.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.7 1.3 0.3 0.6 -0.8
Blood clot in the leg (DVT) 0.2 0.3 0.6 -0.3 -0.5 -0.7 -0.5
Medication: Paracetamol 1.3 2.1 6.8 2.6 0.5 -0.5 -1.0
Headache pain in last month 0.6 1.0 2.7 0.3 1.0 -1.6 -0.6
Medication for cholesterol, blood pressure or diabetes 1.3 2.2 5.0 2.2 0.4 -0.8 -1.8
Glaucoma (self-reported) 0.8 0.9 2.1 1.2 0.1 0.2 -1.4
Gout (self-reported) 0.9 1.2 2.4 -1.1 -1.5 -1.2 0.2
Hypothyroidism/myxoedema (self-reported) 1.0 2.0 3.3 -1.8 -0.3 1.6 1.5
Medication: Amlodipine 0.1 0.2 0.4 0.0 -0.6 0.3 0.6
Medication: Ventolin 100micrograms inhaler 0.5 0.6 2.0 0.5 0.3 -1.4 -0.4
Birth weight 1.1 2.4 7.2 -2.7 0.0 -1.0 1.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.9 -0.1 -0.7 -1.4 -0.2
High blood pressure (siblings) 0.4 0.6 2.0 0.0 1.4 -0.5 0.3
Forced vital capacity (FVC), Best measure 1.9 7.0 14.1 2.6 -0.8 -3.8 -2.5
Body fat percentage 0.1 0.4 0.7 0.5 0.8 0.3 0.7
Leg fat percentage (right) 0.2 0.8 1.3 0.5 0.9 1.1 0.9
Arm fat-free mass (right) 0.8 3.9 6.9 2.4 -1.0 -1.4 -2.6
Exposure to tobacco smoke outside home 0.5 0.6 1.2 1.1 0.1 -0.9 -0.6
Comparative body size at age 10 1.6 4.3 7.2 -2.7 -1.6 -2.5 1.1
Number of full brothers 0.5 0.7 1.5 -0.6 1.2 0.9 0.4
Worry too long after embarrassment 0.6 1.0 2.3 1.0 -0.2 -0.9 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.1 0.9 0.6 0.8 -1.1
Wheeze or whistling in the chest in last year 0.5 0.8 1.9 1.4 1.2 0.1 0.0
Number of children fathered 0.7 0.8 1.4 0.3 -0.5 -1.2 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.5 -1.6 -0.2 -0.7 -0.2
Age at first live birth 0.6 1.0 3.0 0.4 -0.0 -1.7 -0.9
Pulse wave peak to peak time 0.1 0.1 0.2 0.4 -0.4 -0.3 -0.4
Health satisfaction 0.2 0.2 0.7 -0.2 -0.0 -0.9 0.5
Shortness of breath walking on level ground 0.3 0.4 0.8 0.3 -0.2 0.9 0.7
Qualifications: College or University degree 0.2 0.5 0.8 0.9 -0.7 -0.6 -0.6
Eye problems/disorders: None of the above 1.2 1.4 5.0 -0.6 0.1 -2.2 -0.4
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.1 -0.7 -0.1 -1.0 0.2
Emphysema/chronic bronchitis 0.5 0.6 1.0 0.7 -1.0 0.4 -0.8
Medication for pain relief, constipation, heartburn 0.3 0.5 1.8 -1.3 0.3 -0.0 -0.4
Neck or shoulder pain in last month 2.5 3.6 5.6 -2.0 1.9 -1.0 2.4
Medication: Blood pressure 1.2 2.1 4.7 -2.2 -0.7 0.3 1.8
Angina (self-reported) 0.3 0.4 0.9 0.3 0.9 -0.5 0.5
Migraine (self-reported) 1.7 2.2 6.3 -0.3 -2.5 -1.5 0.3
Medication: Ibuprofen 0.8 1.0 3.7 1.9 0.1 -0.2 -0.3
Medication: Allopurinol 1.4 1.8 5.5 -0.5 -2.4 -1.3 -0.0
Medication: Omeprazole 0.3 0.4 0.7 -0.6 0.5 0.3 0.8
Medication: Seretide 50 evohaler 1.5 1.7 4.7 0.6 -0.7 -2.2 -1.1
Mean time to correctly identify matches 1.2 2.2 4.7 -1.1 0.5 2.2 1.6
Heart disease (mother) 0.6 0.8 1.8 0.4 1.4 1.0 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.8 0.8 1.3 0.6 -0.6
Whole body fat mass 0.1 0.5 1.2 1.1 0.4 -0.6 -0.4
Leg fat mass (right) 0.1 0.5 1.4 1.2 0.6 0.1 -0.4
Arm predicted mass (right) 0.7 3.8 6.8 2.1 -1.1 -1.7 -2.6
Pulse rate, automated reading 1.0 3.2 7.9 -0.1 0.4 2.8 2.2
Alcohol intake frequency. 0.0 0.0 0.2 0.4 -0.0 0.2 -0.0
Comparative height size at age 10 2.9 16.1 31.5 2.3 0.5 -5.6 -5.2
Number of full sisters 0.8 0.9 2.9 1.7 0.2 -0.3 -0.8
Suffer from ‘nerves’ 0.2 0.4 0.7 0.5 0.8 0.5 0.7
Overall health rating 0.2 0.5 0.8 0.9 -0.9 -0.7 -0.1
Chest pain or discomfort 3.4 4.9 13.3 3.6 0.1 0.7 -2.4
Had major operations 0.2 0.3 0.9 0.2 -0.9 -0.2 0.4
Age at last live birth 0.1 0.2 0.7 -0.1 0.3 -0.8 -0.1
Family relationship satisfaction 0.6 0.7 2.0 -1.4 -0.0 -0.5 0.9
Leg pain on walking 0.2 0.2 0.7 0.8 -0.3 -0.1 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 1.6 0.4 1.3 -1.2 -1.2
Commuting to job workplace: Car/motor vehicle 1.6 1.9 5.1 -0.1 -2.3 -1.5 -0.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.6 -0.8 0.7 -0.2 0.5
Medication: Aspirin 0.9 1.1 2.4 0.1 0.2 1.5 1.5
Supplements: Vitamin C 0.4 0.4 1.1 -0.6 0.1 -1.0 -0.6
Knee pain experienced in last month 0.6 1.0 1.4 1.2 0.2 -1.2 -1.0
Hypertension (Self-reported) 0.8 2.2 3.5 -1.9 0.1 1.7 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.8 0.2 -0.8 -1.7 -1.3
Illnesses of father: Heart disease 0.2 0.3 0.9 -0.4 0.4 -1.0 -0.2
Illnesses of siblings: Diabetes 0.0 0.0 0.1 0.3 0.3 0.0 -0.0
Smoking status: Previous 0.2 0.3 0.6 -0.6 0.1 0.8 0.4
Forced expiratory volume in 1-second (FEV1), predicted 4.8 10.0 18.6 2.8 -1.2 -4.3 -3.5
Whole body fat-free mass 1.0 5.6 10.0 2.4 -1.4 -2.1 -3.2
Leg fat-free mass (right) 1.1 6.0 8.8 2.2 -1.9 -2.6 -3.0
Arm fat percentage (left) 0.1 0.3 0.6 0.5 0.4 0.1 0.8
Average weekly red wine intake 0.5 0.8 1.1 0.2 1.1 -0.9 -1.0
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.6 1.3 -0.9 -0.2 -0.8
Mood swings 0.2 0.3 0.7 0.5 0.1 0.7 0.8
Loneliness, isolation 1.0 1.4 2.2 -0.6 -1.5 1.3 1.2
Long-standing illness, disability or infirmity 0.7 1.1 2.6 1.6 0.5 0.1 -1.2
Ever had bowel cancer screening 2.8 3.2 6.5 -2.6 0.1 -0.8 2.4
Diabetes diagnosed by doctor 0.3 0.5 1.9 -0.2 0.2 1.4 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 2.7 2.9 6.2 2.5 -0.6 -1.5 -1.6
Friendships satisfaction 0.6 0.7 1.5 -0.6 0.4 0.9 1.2
Qualifications: nursing, teaching 0.8 1.2 1.9 1.4 -0.3 -1.0 -1.3
Commuting to job workplace: Walk 0.1 0.2 0.3 0.5 0.3 0.2 -0.5
Eye problems/disorders: Cataract 2.1 2.4 8.1 0.6 -0.2 2.8 1.0
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.8 0.1 -2.0 -1.2 0.3
Medication for cholesterol 0.1 0.1 0.2 -0.4 -0.3 0.0 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 2.7 0.8 1.2 1.6 -0.6
Back pain experienced in last month 0.6 0.8 1.5 -0.7 1.2 0.3 1.0
Mineral and other dietary supplements 0.4 0.5 1.3 0.6 0.5 -1.1 -0.1
Breast cancer (self-reported) 0.4 0.5 1.1 0.8 -0.2 0.2 -1.1
Asthma (self-reported) 0.2 0.3 0.8 0.4 0.9 -0.5 -0.1
Osteoporosis (self-reported) 1.5 1.9 3.0 -1.3 -1.7 0.9 1.5
Osteoarthritis (self-reported) 0.5 0.7 1.3 -0.5 1.0 0.6 1.1
Medication: Aspirin 1.4 1.8 4.1 -0.1 0.4 2.0 1.7
Medication: Gliclazide 0.8 0.8 2.7 -0.7 -1.6 -0.4 0.3
Illnesses of father: None of the above (group 1) 1.6 1.9 3.5 1.8 -0.1 0.9 -1.9
Smoking status: Current 0.4 0.6 1.1 1.0 -0.7 -0.1 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.1 1.1 0.6 -0.8 -1.0
Whole body water mass 1.0 5.5 10.0 2.4 -1.4 -2.1 -3.2
Leg predicted mass (right) 1.1 6.1 8.9 2.2 -1.9 -2.7 -3.0
Arm fat mass (left) 0.1 0.4 1.3 1.1 0.2 -0.5 -0.2
Number of self-reported non-cancer illnesses 0.6 1.0 2.5 -1.2 -0.1 0.2 1.6
Average weekly champagne plus white wine intake 0.3 0.5 1.2 0.5 1.1 0.5 -0.3
Miserableness 0.0 0.1 0.1 0.3 0.1 -0.3 -0.0
Guilty feelings 0.4 0.6 1.6 0.6 -1.3 -0.5 -0.5
Wears glasses or contact lenses 0.3 0.4 0.5 -0.6 -0.6 -0.7 -0.5
Ever taken oral contraceptive pill 0.7 0.8 1.1 -0.7 -0.8 -0.9 1.0
Hearing aid user 0.1 0.1 0.1 0.3 -0.3 0.0 -0.1
Mother’s age at death 0.9 1.1 2.1 -1.4 0.2 1.2 1.0
Financial situation satisfaction 0.5 0.6 1.1 -0.7 0.4 0.8 1.0
Tinnitus: Yes, now most or all of the time 1.5 1.8 5.1 -1.1 -0.9 -2.2 0.4
Commuting to job workplace: Public transport 0.7 0.9 1.9 0.8 1.4 0.4 -0.8
Eye problems/disorders: Glaucoma 0.8 1.0 1.7 1.3 -0.5 -0.5 -1.2
Medication: Blood pressure 0.5 0.9 1.5 -1.0 0.1 0.9 1.2
Pain type(s) experienced in last month: Hip pain 0.9 1.1 1.7 -0.9 1.2 0.7 1.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.4 0.1 -1.2 0.6 -0.1
High cholesterol (Self-reported) 0.8 1.5 3.8 0.0 0.6 1.9 1.3
Medication: Bendroflumethiazide 0.5 0.7 2.5 -1.6 0.4 0.0 0.4
Medication: Paracetamol 2.3 3.6 8.2 2.9 1.0 -1.1 -2.0
Medication: Lisinopril 1.0 1.3 3.7 -1.2 -0.3 -0.2 1.9
Medication: Atorvastatin 0.9 1.1 2.2 1.3 1.5 -0.5 -0.4
Illnesses of father: High blood pressure 0.3 0.3 1.1 -0.2 0.1 -1.0 0.4
Alcohol drinker status: Never 0.6 0.8 1.0 1.0 -0.8 -0.8 -0.9
Ever smoked 0.3 0.5 1.2 0.7 -0.3 0.2 -1.1
Basal metabolic rate 1.0 5.3 9.1 2.5 -1.1 -2.2 -3.0
Leg fat percentage (left) 0.1 0.3 0.6 0.5 0.2 0.5 0.8
Arm fat-free mass (left) 0.7 3.3 5.7 2.1 -0.7 -1.5 -2.4
Number of operations (self-reported) 0.3 0.4 1.2 -0.3 0.0 -1.1 -0.5
Average weekly beer plus cider intake 0.3 0.5 1.6 0.4 -0.1 1.3 -0.2
Irritability 0.6 1.1 2.4 0.2 0.8 1.6 1.1
Risk taking 0.5 0.8 2.1 0.8 -1.4 0.2 0.6
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.3 -0.5 0.4 -0.5 0.1
Fractured/broken bones in last 5 years 0.6 0.7 2.2 -0.1 0.7 -1.5 -0.5
Age started oral contraceptive pill 1.0 1.2 4.4 -0.1 0.0 2.1 0.6
Diastolic blood pressure, automated reading 1.1 3.4 7.6 -1.4 0.1 2.0 2.8
Ever depressed for a whole week 0.4 0.6 1.0 -0.6 -1.0 -0.5 0.8
Unable to work because of sickness or disability 0.4 0.5 1.7 0.3 -0.2 -1.3 -0.5
Commuting to job workplace: Cycle 2.3 2.8 9.1 0.6 3.0 -0.7 -1.2
Myopia 0.9 1.3 2.6 0.7 0.1 -1.6 -1.4
Vascular/heart problems diagnosed by doctor 1.0 2.8 3.9 2.0 0.0 -1.8 -1.9
Cholesterol lowering medication 1.1 1.6 4.3 2.1 -0.8 1.1 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.6 -0.4 0.4 0.5 0.8
Pain experienced in last month 1.2 2.1 6.4 0.3 -2.5 1.3 -0.2
Supplements: Calcium 0.5 0.6 1.4 -1.2 -0.4 0.6 0.7
Basal cell carcinoma (self-reported) 1.5 1.8 4.6 1.2 1.2 2.1 0.0
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.9 -0.4 -0.1 0.3 0.9
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.7 -0.6 -0.5 -0.8 -0.4
Heart disease (siblings) 0.8 1.0 2.8 1.1 1.7 0.1 -0.3
Alcohol drinker status: Previous 0.4 0.5 1.5 0.6 -0.1 1.2 -0.3
Pack years of smoking 1.6 2.4 5.4 -1.0 0.2 2.3 1.8
Impedance of whole body 0.1 0.6 1.0 -0.4 0.7 -1.0 0.8
Leg fat mass (left) 0.1 0.4 1.3 1.1 0.1 -0.2 -0.3
Arm predicted mass (left) 0.7 3.5 6.7 2.0 -0.6 -1.7 -2.6