TWAS hub - C22orf15

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Glioblastoma Multiforme	0.1450	0.0760	0.0098	0.084	0.040	0.044	NA	0.084	0.0016	0.0220	0.018	NA	0.0016
2	TCGA	Lung Adenocarcinoma	0.0285	0.0144	0.0021	0.013	0.008	0.005	NA	0.004	0.0092	0.0380	0.077	NA	0.1000
3	TCGA	Lung Squamous Cell Carcinoma	0.0359	0.0181	0.0032	0.000	0.022	0.013	NA	0.008	0.3200	0.0013	0.011	NA	0.0350

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Lansoprazole	6.2	7.1	13.3	-3.6	2.7	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.4	5.2	8.5	-2.9	2.6	0.7
Medication: Co-codamol	4.1	4.7	7.1	-2.4	2.7	1.1
High blood pressure (mother)	3.9	5.5	8.2	-2.5	2.9	1.4
Alcohol usually taken with meals	3.4	5.5	7.6	-1.8	2.4	2.8
Medication: Bendroflumethiazide	3.4	5.2	10.2	-3.2	2.3	0.7
Impedance of arm (right)	3.1	14.2	29.2	-0.4	-3.7	-5.4
Mineral and other dietary supplements	3.1	4.2	8.2	-1.4	-1.6	-2.9
Commuting to job workplace: Walk	3.0	3.3	7.2	-0.9	2.7	1.4
Depression (self-reported)	2.9	3.4	5.4	-2.0	-1.0	-2.3
Supplements: Fish oil (including cod liver oil)	2.9	3.8	5.7	1.3	2.0	2.4
Health satisfaction	2.8	3.6	5.2	-1.2	-2.0	-2.3
Illnesses of father: Heart disease	2.8	3.8	5.5	-2.0	2.3	1.4
Birth weight of first child	2.6	4.7	8.7	3.0	-2.3	-0.3
Illnesses of father: None of the above (group 1)	2.6	3.2	4.3	1.4	-2.1	-1.9
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	6.2	2.5	-0.0	1.5
Loud music exposure frequency	2.5	2.7	4.9	1.0	-2.2	-1.5
Diastolic blood pressure, automated reading	2.5	7.8	14.7	-0.3	3.0	3.8
Fasting Glucose	2.4	2.9	5.7	0.9	-2.4	-1.5
Impedance of arm (left)	2.4	11.1	22.7	-0.5	-3.2	-4.8
Number of full sisters	2.4	2.9	4.6	-2.2	1.8	0.9
Blood Red Count	2.2	21.5	38.9	1.1	4.9	6.2
Falls in the last year	2.2	2.9	4.3	1.6	-2.1	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	7.3	-2.7	1.6	-0.5
Happiness	2.1	2.6	6.5	0.4	1.0	2.6
Medication: Amlodipine	2.1	2.9	5.7	0.6	1.7	2.4
Smoking status: Previous	2.1	3.2	4.0	-1.3	-1.9	-2.0
Illnesses of father: High blood pressure	2.1	2.6	3.9	-1.6	2.0	1.2
Birth weight	2.0	4.4	8.8	0.6	2.0	3.0
Ulcerative Colitis (UC)	1.9	3.5	8.1	2.8	-0.4	1.6
Medication: Omeprazole	1.9	2.3	5.6	-0.9	-0.7	-2.4
Ever taken oral contraceptive pill	1.9	2.1	2.5	-1.3	-1.6	-1.5
Hand grip strength (left)	1.8	4.8	10.1	1.1	1.8	3.2
Had menopause	1.8	2.3	4.6	-0.7	-2.2	-1.3
Hearing aid user	1.8	2.0	3.1	-0.3	1.7	1.8
Impedance of whole body	1.8	9.4	17.2	0.4	-3.3	-4.1
Shortness of breath walking on level ground	1.7	2.0	3.0	0.1	-1.7	-1.7
Supplements: Calcium	1.7	1.9	2.7	-1.6	1.5	0.8
Coronary Artery Disease (CAD)	1.6	1.9	3.4	0.2	1.8	1.5
Pulse wave reflection index	1.6	2.0	3.2	-1.2	1.8	1.1
Medication: Paracetamol	1.6	2.6	4.5	0.5	-1.8	-2.1
Arm predicted mass (right)	1.6	8.2	16.9	-0.5	2.7	4.1
Ever smoked	1.6	2.9	4.6	-0.3	-2.0	-2.1
Mean Putamen Volume	1.5	1.7	2.7	1.6	-1.5	-0.3
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	3.0	-1.7	1.6	0.7
High blood pressure	1.5	4.1	6.1	-1.3	2.5	2.1
Arm fat-free mass (right)	1.5	7.7	16.9	-0.0	2.5	4.1
Medication: Gliclazide	1.5	1.7	4.8	2.2	-0.4	0.2
Tinnitus: Yes, now most or all of the time	1.5	1.7	2.5	-0.8	1.4	1.6
Alcohol drinker status: Previous	1.5	1.7	2.8	-1.4	-0.6	-1.7
Systolic blood pressure, automated reading	1.4	4.1	5.4	-1.6	2.1	2.3
Financial difficulties in last 2 years	1.4	1.9	4.0	-0.7	-1.1	-2.0
Fluid intelligence score	1.4	3.0	5.1	-1.7	2.3	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	3.6	-1.9	1.8	0.3
Hair/balding pattern: Pattern 4	1.4	3.3	5.4	-0.0	-2.1	-2.3
Friendships satisfaction	1.4	1.7	2.1	-1.0	1.4	1.5
Wears glasses or contact lenses	1.4	1.6	3.3	0.5	1.1	1.8
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.4	-1.6	0.6	-1.5
Bipolar Disorder (2018)	1.3	2.0	4.7	-0.4	1.1	2.2
Irritable Bowel Disease (IBD)	1.3	3.2	6.2	2.5	-0.5	1.8
Systolic Blood Pressure	1.3	6.6	9.8	-1.2	3.1	2.9
Cardiovascular Disease	1.3	4.2	5.5	-2.2	2.3	1.5
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.2	1.8	-0.9	0.4
Vitamin and mineral supplements	1.3	1.7	3.1	1.2	-1.8	-0.8
Supplements: Zinc	1.3	1.5	3.0	-1.1	1.7	0.5
Impedance of leg (left)	1.3	6.4	8.8	1.6	-3.0	-2.8
Noisy workplace	1.3	1.6	3.0	1.3	0.2	1.7
Age at first live birth	1.3	2.3	3.2	0.8	-1.8	-1.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.0	1.2	0.4	1.7
Taking other prescription medications	1.2	1.9	4.5	-2.1	1.1	-0.0
Multivitamins +/- minerals	1.2	1.5	2.7	-1.2	1.6	0.6
Past tobacco smoking	1.2	2.2	3.0	0.7	1.7	1.7
Heart attack	1.2	1.5	2.5	1.6	0.8	1.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.4	-1.5	1.5	0.6
Gout (self-reported)	1.2	1.7	2.3	-0.8	-1.4	-1.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	3.5	-1.9	1.4	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.4	-1.5	1.5	0.2
Medication: Seretide 50 evohaler	1.2	1.4	3.2	-0.2	-1.0	-1.8
Pulse rate, automated reading	1.2	3.9	6.1	1.8	-2.5	-1.6
Miserableness	1.2	2.0	4.9	-2.2	0.9	-0.7
Arm fat-free mass (left)	1.2	6.0	12.5	-0.5	2.3	3.5
Vascular/heart problems diagnosed by doctor	1.2	3.1	5.0	1.0	-2.2	-1.9
Arm predicted mass (left)	1.2	6.0	12.2	-0.5	2.3	3.5
Angina	1.1	1.5	3.3	-0.1	1.8	1.0
Medication: Levothyroxine sodium	1.1	1.8	3.6	-1.9	1.2	0.5
Hip circumference	1.1	4.8	8.2	-2.9	2.2	1.2
Breastfed as a baby	1.1	1.4	2.1	-1.0	1.0	1.4
Comparative body size at age 10	1.1	2.9	4.2	-1.1	2.0	1.8
Angina (self-reported)	1.1	1.4	3.2	-0.0	1.8	1.0
Age at last live birth	1.1	1.5	2.2	0.5	-1.5	-1.5
Alcohol drinker status: Never	1.1	1.4	3.5	-1.9	0.4	-0.7
Alzheimer’s Disease (in father)	1.0	1.1	1.9	1.4	-1.2	-0.1
Chronotype (morning person)	1.0	2.4	5.1	-2.3	1.3	0.4
Average weekly spirits intake	1.0	1.3	3.1	1.8	-0.9	-0.1
Medication: Metformin	1.0	1.4	2.2	1.5	-1.1	-0.9
Hand grip strength (right)	1.0	2.9	7.5	0.7	0.7	2.7
Hair/balding pattern: Pattern 2	1.0	1.2	2.4	1.1	0.4	1.5
Pain all over the body in last month	1.0	1.0	1.6	0.4	1.2	1.3
Number of live births	1.0	1.4	2.5	-1.2	1.6	0.5
Illnesses of mother	1.0	1.2	1.6	0.7	-1.3	-1.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.9	1.2	-1.4	-0.5
Exposure to tobacco smoke outside home	1.0	1.3	3.2	1.8	-0.8	0.2
Medication for pain relief, constipation, heartburn	1.0	1.7	4.1	-0.3	1.0	2.0
Hypertension (Self-reported)	1.0	2.7	3.6	-1.3	1.9	1.7
Back pain experienced in last month	1.0	1.5	3.4	-1.8	0.6	-0.8
Average weekly champagne plus white wine intake	1.0	1.3	2.4	-0.2	-1.2	-1.6
Number of operations (self-reported)	1.0	1.5	3.4	-0.2	-1.0	-1.9
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.4	-0.8	-0.8	-1.6
Cholesterol lowering medication	1.0	1.5	1.7	-1.3	1.2	1.1
Basal cell carcinoma (self-reported)	1.0	1.2	1.8	-1.4	1.3	0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.0	1.4	0.8	1.1
Townsend deprivation index at recruitment	0.9	1.3	2.0	-1.4	1.1	-0.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.1	0.8	-1.1	-1.1
Stomach or abdominal pain in last month	0.9	1.1	1.7	-1.3	1.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.5	-0.8	-0.3	-1.6
Waist circumference	0.9	3.2	4.2	-2.0	2.1	1.2
Trunk fat-free mass	0.9	5.3	10.8	-0.4	2.2	3.3
Time employed in main current job	0.9	1.0	1.9	1.0	-1.4	-0.3
Trunk predicted mass	0.9	5.4	11.2	-0.3	2.2	3.3
Pulse wave peak to peak time	0.9	1.1	1.6	1.3	-0.9	-0.9
Whole body fat-free mass	0.9	5.0	9.7	-0.8	2.2	3.1
Medication: Paracetamol	0.9	1.4	2.9	0.4	-1.1	-1.7
Ever depressed for a whole week	0.9	1.2	1.5	-1.2	-0.9	-1.1
Schizophrenia vs Biploar Disorder	0.8	1.0	2.0	-0.1	-1.0	-1.4
Alzheimer’s Disease (including proxy)	0.8	1.1	2.2	1.5	-0.3	1.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.1	-0.4	0.6	1.5
Blood Eosinophil Count	0.8	5.9	8.9	-3.0	2.8	1.0
Trunk fat percentage	0.8	3.2	6.4	-2.5	-0.5	-1.7
Body mass index (BMI)	0.8	3.3	5.6	-2.4	1.8	1.0
Number of incorrect matches in round	0.8	1.4	3.4	0.5	-1.8	-0.7
Arm fat percentage (right)	0.8	3.0	6.8	-2.6	0.2	-1.5
Pulse rate	0.8	1.3	2.3	1.2	-1.5	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.7	-1.3	0.5	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.3	-0.3	0.4	-1.5
Smoking status: Current	0.8	1.2	1.6	1.3	1.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	2.7	-0.4	1.4	1.7
Whole body water mass	0.8	4.8	9.1	-0.9	2.1	3.0
Medication: Blood pressure	0.8	1.5	3.6	-1.9	1.0	-0.1
Average weekly beer plus cider intake	0.8	1.1	1.4	0.9	-1.2	-1.1
Crohns Disease (2017)	0.7	1.6	2.8	1.7	-0.5	1.3
Major Depression (MDD)	0.7	0.9	1.9	0.0	-0.9	-1.4
Crohns Disease (2012)	0.7	1.2	2.5	0.9	0.4	1.6
HbA1C	0.7	0.8	2.0	1.4	-0.6	0.2
Number of treatments/medications taken	0.7	1.2	2.3	-1.5	1.1	0.2
Hearing difficulty/problems: Yes	0.7	1.0	2.3	-1.5	0.8	-0.4
Impedance of leg (right)	0.7	3.4	5.1	1.3	-1.8	-2.3
Current tobacco smoking	0.7	1.2	2.3	1.5	0.9	0.7
Hearing difficulty/problems with background noise	0.7	1.2	1.9	-1.4	1.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	-0.4	1.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.3	0.5	-1.1	-0.9
Emphysema/chronic bronchitis	0.7	0.8	1.8	0.7	-0.1	1.4
Medication: Ibuprofen	0.7	0.9	1.4	-0.6	-0.9	-1.2
Chest pain or discomfort	0.7	1.1	2.3	-0.3	0.9	1.5
Arm fat percentage (left)	0.7	2.8	6.8	-2.6	0.4	-1.2
Loneliness, isolation	0.7	0.9	1.4	-0.4	-1.2	-1.1
Medication: Lisinopril	0.7	1.0	1.5	-1.1	-0.4	-1.2
Basal metabolic rate	0.7	4.1	7.1	-1.1	2.0	2.7
Bipolar Disorder or Schizophrenia	0.6	1.4	3.6	0.2	0.8	1.9
Medication for hormone replacement therapy	0.6	0.6	1.5	1.2	-0.6	0.1
Leg fat-free mass (left)	0.6	2.9	4.0	-1.4	1.6	2.0
Age when periods started (menarche)	0.6	1.3	2.7	1.6	0.1	1.2
Qualifications: CSEs or equivalent	0.6	0.7	1.5	-0.8	1.2	0.4
Pulse wave Arterial Stiffness index	0.6	0.7	1.1	-1.1	0.7	0.7
Body fat percentage	0.6	2.5	5.1	-2.3	-0.3	-1.6
Migraine (self-reported)	0.6	0.7	2.1	1.4	-0.4	0.1
Heart disease (mother)	0.6	0.7	1.1	-1.0	1.0	-0.2
Had major operations	0.6	0.7	1.3	-0.6	-0.6	-1.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.4	0.8	-1.2	0.3
Knee pain experienced in last month	0.6	0.9	1.4	-1.0	-0.4	-1.2
Mood swings	0.6	1.1	1.6	-0.4	-1.2	-1.3
Mother’s age at death	0.6	0.7	1.8	0.4	0.4	1.3
Commuting to job workplace: Public transport	0.6	0.7	0.8	0.8	-0.8	-0.9
Heart disease (siblings)	0.6	0.7	1.1	-0.3	1.1	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	-0.8	1.6	0.6
Body Mass Index (BMI) (2010)	0.5	0.7	1.2	-1.1	0.9	-0.2
Lung FEV1/FVC ratio	0.5	2.6	4.8	-2.2	1.6	0.7
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	0.5	-1.1	-0.5
Severe depression (siblings)	0.5	0.6	1.6	-0.3	1.3	0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	-0.5	-1.0	-0.8
Leg predicted mass (left)	0.5	2.9	3.9	-1.4	1.6	2.0
Trunk fat mass	0.5	2.3	6.2	-2.5	0.0	-0.8
Hair/balding pattern: Pattern 3	0.5	0.7	1.6	1.3	-0.4	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	-0.2	-1.0	-0.9
Arm fat mass (right)	0.5	2.0	5.1	-2.3	1.0	0.1
Headache pain in last month	0.5	0.9	1.5	-1.2	0.9	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.8	1.3	-0.3	0.2
Medication: Blood pressure	0.5	0.9	1.2	1.1	0.6	1.1
Medication: Allopurinol	0.5	0.6	1.2	-0.7	-0.3	-1.1
Alcohol intake frequency.	0.5	1.1	2.8	-1.7	0.7	0.2
Eye problems/disorders: Cataract	0.5	0.6	1.0	1.0	-0.1	0.9
Medication for cholesterol	0.5	0.8	1.0	0.7	-0.8	-1.0
Arm fat mass (left)	0.5	2.1	5.4	-2.3	1.0	0.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-1.0	0.9	0.1
High cholesterol (Self-reported)	0.5	0.9	2.5	-1.6	0.2	-0.3
Risk taking	0.5	0.7	1.2	-1.1	-0.1	-0.9
Unable to work because of sickness or disability	0.5	0.7	1.1	-1.0	0.7	-0.7
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	0.3	0.4	1.1
Ovarian Cancer	0.4	0.5	1.2	-0.3	-0.5	-1.1
Lung FVC	0.4	2.3	3.5	1.7	0.6	1.9
Average weekly fortified wine intake	0.4	0.5	1.3	1.1	-0.3	0.1
Serious illness, injury or assault to yourself	0.4	0.4	1.0	-1.0	0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.1	-1.0	0.9	0.3
Had other major operations	0.4	0.5	0.9	-0.8	0.9	-0.3
Weight	0.4	1.8	3.2	-1.8	1.1	1.1
Medication: Cholesterol lowering	0.4	0.7	1.4	1.2	-0.5	-0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	-0.8	1.0	0.3
Leg fat percentage (right)	0.4	1.6	3.6	-1.9	0.2	-1.1
Number of full brothers	0.4	0.5	0.7	0.9	-0.8	0.5
Eye problems/disorders: None of the above	0.4	0.5	1.1	-0.2	-0.5	-1.1
Whole body fat mass	0.4	1.6	4.6	-2.1	0.2	-0.5
Overall health rating	0.4	0.8	1.4	-1.2	0.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.3	0.6	-0.2	1.1
Guilty feelings	0.4	0.6	1.3	-1.1	-0.1	-0.8
Leg fat percentage (left)	0.4	1.6	3.0	-1.7	-0.4	-1.2
Pain experienced in last month	0.4	0.7	1.2	1.0	0.2	1.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.9	-0.5	1.4	0.6
Neuroticism (Nagel 2018)	0.3	0.6	1.5	-1.2	-0.1	-0.6
Prostate Cancer	0.3	0.4	0.7	0.8	-0.3	0.5
LDL Cholesterol	0.3	0.5	0.9	1.0	-0.8	-0.2
Neuroticism (2016)	0.3	0.5	1.0	-1.0	0.6	0.4
BMI	0.3	1.8	2.4	-1.5	1.5	0.9
Allergy or Eczema	0.3	0.7	1.5	-0.1	1.2	0.7
Respiratory disease	0.3	0.6	0.9	-1.0	1.0	0.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	-0.7	-0.8	-0.4
Maternal smoking around birth	0.3	0.4	0.9	1.0	-0.5	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.5	-0.6	1.2	0.3
Supplements: Glucosamine	0.3	0.4	0.7	0.1	0.6	0.8
Nervous feelings	0.3	0.5	0.8	-0.9	0.9	0.3
Mouth/teeth dental problems	0.3	0.4	0.9	-0.6	0.1	-0.9
Allergy	0.3	0.6	1.5	-1.2	-0.3	-0.6
Medication: Simvastatin	0.3	0.4	0.8	-0.2	0.9	0.6
Father’s age at death	0.3	0.4	0.9	0.3	0.9	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.2	-0.8	0.6	1.5
Prospective memory result	0.3	0.3	0.5	-0.2	0.7	0.7
Exposure to tobacco smoke at home	0.3	0.4	0.7	0.0	-0.6	-0.8
Peak expiratory flow (PEF)	0.3	0.6	1.6	-0.3	0.4	1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.9	0.3	0.2	0.9
Blood clot in the leg (DVT)	0.3	0.3	0.6	0.8	-0.6	0.2
High blood pressure (siblings)	0.3	0.5	0.9	-0.5	0.9	0.6
Number of children fathered	0.3	0.3	0.5	0.6	-0.5	-0.7
Qualifications: College or University degree	0.3	0.9	1.2	0.6	1.1	1.0
Leg fat mass (right)	0.3	1.0	2.8	-1.7	0.4	-0.3
Medication: Aspirin	0.3	0.4	0.9	0.9	-0.4	-0.4
Supplements: Vitamin C	0.3	0.4	1.0	1.0	-0.3	0.1
Leg fat-free mass (right)	0.3	1.7	3.0	-1.1	1.0	1.7
Average weekly red wine intake	0.3	0.5	1.2	0.4	0.2	1.1
Breast cancer (self-reported)	0.3	0.3	0.8	0.3	-0.0	0.9
Leg predicted mass (right)	0.3	1.7	2.9	-1.1	1.0	1.7
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	-0.7	0.8	0.6
Medication: Atorvastatin	0.3	0.3	0.6	-0.0	-0.8	-0.6
Irritability	0.3	0.6	1.7	-1.3	0.1	0.2
Fractured/broken bones in last 5 years	0.3	0.4	1.0	-0.1	-0.3	-1.0
Myopia	0.3	0.4	0.6	0.7	-0.8	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	0.8	-0.7	-0.0
Depressed Affect (Nagel 2018)	0.2	0.3	0.5	-0.3	-0.7	-0.6
Depression (Nagel 2018)	0.2	0.4	0.9	-0.1	-1.0	-0.4
Worry (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.3	-0.5
Lupus	0.2	0.3	0.8	0.5	-0.9	-0.0
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.2	-0.9	-0.4
Rheumatoid Arthritis	0.2	0.3	0.7	0.8	-0.2	-0.5
Blood White Count	0.2	1.7	3.3	-0.4	1.2	1.8
Heel T-Score	0.2	1.5	3.2	1.8	0.3	1.1
Waist Hip Ratio (WHR)	0.2	0.9	1.3	0.9	-0.8	-1.2
Smoking Status	0.2	0.5	1.3	-0.0	-0.4	-1.1
Hypothyroidism (self reported)	0.2	0.5	0.8	-0.7	0.4	0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	-0.3	-0.3	-1.0
Diabetes (father)	0.2	0.2	0.6	-0.2	0.0	0.8
Diabetes (mother)	0.2	0.3	0.4	0.7	-0.4	0.5
Relative age voice broke	0.2	0.4	1.1	-1.1	-0.1	-0.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.1	1.0	0.5
Medication: Atenolol	0.2	0.2	0.6	0.8	0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-0.5	1.0	0.3
Qualifications: None of the above	0.2	0.5	0.9	0.9	-0.6	0.3
Illnesses of siblings	0.2	0.2	0.3	-0.1	-0.5	-0.6
Neuroticism score	0.2	0.3	0.5	-0.7	-0.3	-0.6
Lung cancer (father)	0.2	0.2	0.4	-0.1	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.4	-0.7	0.2	1.2
Length of working week for main job	0.2	0.2	0.5	0.4	-0.7	0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	0.5	0.5	0.3
Forced vital capacity (FVC), Best measure	0.2	0.6	1.1	0.7	-1.1	0.4
Worry too long after embarrassment	0.2	0.3	0.5	-0.6	0.7	0.0
Comparative height size at age 10	0.2	0.9	2.4	-0.3	-1.5	-0.5
Suffer from ‘nerves’	0.2	0.3	0.5	-0.6	0.7	0.1
Leg pain on walking	0.2	0.2	0.3	0.5	0.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	-0.3	0.8	-0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.7	-0.2	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.7	0.4	0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.5	-0.5	0.5	0.7
Ever had bowel cancer screening	0.2	0.2	0.2	0.5	-0.4	0.4
Asthma (self-reported)	0.2	0.4	1.1	1.0	-0.1	-0.1
Osteoporosis (self-reported)	0.2	0.3	0.8	0.2	-0.2	0.9
Age started oral contraceptive pill	0.2	0.2	0.5	-0.3	0.0	0.7
Leg fat mass (left)	0.2	0.7	2.0	-1.4	0.2	-0.2
Schizophrenia (2018)	0.1	0.3	0.5	0.6	0.2	0.7
Breast Cancer	0.1	0.3	0.4	-0.6	0.2	-0.6
Age at First Birth	0.1	0.1	0.2	-0.2	0.4	0.5
HDL Cholesterol	0.1	0.1	0.4	-0.6	0.2	0.2
Triglycerides	0.1	0.2	0.5	0.1	0.7	0.2
Blood Platelet Count	0.1	0.9	2.2	1.5	0.2	0.6
Height	0.1	2.0	4.1	2.0	-1.3	0.5
Neuroticism	0.1	0.3	0.6	-0.8	-0.5	-0.3
Tanning	0.1	0.9	1.8	1.4	0.5	0.8
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.5	0.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.2	0.2	0.6
Fed-up feelings	0.1	0.2	0.4	0.2	0.1	0.6
Sitting height	0.1	0.9	2.2	0.6	-1.5	0.4
Forced vital capacity (FVC)	0.1	0.3	0.4	0.4	-0.6	0.6
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.4	0.0	-0.7
Worrier / anxious feelings	0.1	0.3	0.6	-0.8	-0.3	-0.2
Asthma	0.1	0.1	0.4	0.6	-0.0	-0.3
Standing height	0.1	1.4	1.9	1.3	-1.4	0.6
Tense / ‘highly strung’	0.1	0.2	0.4	-0.7	0.3	0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.7	-0.8	0.1	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.0	-0.4	0.3
Mean time to correctly identify matches	0.1	0.1	0.4	0.2	-0.6	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.1	-0.0	0.4
Family relationship satisfaction	0.1	0.2	0.4	-0.2	0.2	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.7	-0.1	-0.2
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.1	0.4	0.1
Medication: Aspirin	0.1	0.1	0.2	0.4	0.1	-0.3
Financial situation satisfaction	0.1	0.2	0.3	0.1	-0.5	0.5
Pack years of smoking	0.1	0.1	0.2	0.4	-0.2	0.3
Reaction Time	0.0	0.0	0.1	-0.1	-0.3	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.1	0.2	-0.5	-0.2	0.1
Ulcerative Colitis	0.0	0.1	0.1	0.2	0.1	0.4
Hair Pigment	0.0	0.1	0.3	0.2	-0.2	-0.6
Relative age of first facial hair	0.0	0.1	0.1	-0.3	-0.1	-0.3
Pack years adult smoking proportion	0.0	0.0	0.0	0.2	-0.2	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.3	-0.0	0.2
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.0	-0.4	0.1
Diabetes (self-reported)	0.0	0.0	0.1	0.2	-0.1	-0.3
Medication: Ramipril	0.0	0.0	0.0	0.0	-0.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	0.5	0.0	0.2
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.0	-0.2	-0.3
Glaucoma (self-reported)	0.0	0.0	0.1	-0.3	-0.0	0.1
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	-0.4	0.2	0.0
Neck or shoulder pain in last month	0.0	0.0	0.0	0.1	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	0.1	-0.2	0.3
Qualifications: nursing, teaching	0.0	0.0	0.1	0.3	-0.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	-0.3	0.0	0.3
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.0	-0.3	0.1

Hub : Genes

C22orf15

Models

Trait associations